#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14745	uniprotkb:P09619	intact:EBI-349787|uniprotkb:O43552|uniprotkb:Q86WQ5|ensembl:ENSP00000262613|uniprotkb:B3KY21|intact:EBI-15579389	intact:EBI-641237|uniprotkb:Q8N5L4|uniprotkb:B5A957|ensembl:ENSP00000261799	psi-mi:nhrf1_human(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:pgfrb_human(display_long)|uniprotkb:CD140 antigen-like family member B(gene name synonym)|uniprotkb:PDGFRB(gene name)|psi-mi:PDGFRB(display_short)|uniprotkb:Beta-type platelet-derived growth factor receptor(gene name synonym)|uniprotkb:PDGFR(gene name synonym)|uniprotkb:Platelet-derived growth factor receptor 1(gene name synonym)|uniprotkb:Beta platelet-derived growth factor receptor(gene name synonym)|uniprotkb:PDGFR1(gene name synonym)	psi-mi:"MI:0096"(pull down)	- (2013)	imex:IM-21392|pubmed:24012959	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8697437|imex:IM-21392-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004243.1|ensembl:ENSG00000109062(gene)|ensembl:ENST00000262613(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015185"(gamma-aminobutyric acid transmembrane transporter activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0031982"(vesicle)|go:"GO:0032415"("regulation of sodium:proton antiporter activity")|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044782"(cilium organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|interpro:IPR041489|mint:O14745|rcsb pdb:1G9O|rcsb pdb:1GQ4|rcsb pdb:1GQ5|rcsb pdb:1I92|rcsb pdb:1SGH|rcsb pdb:2D10|rcsb pdb:2JXO|rcsb pdb:2KJD|rcsb pdb:2KRG|rcsb pdb:2M0T|rcsb pdb:2M0U|rcsb pdb:2M0V|rcsb pdb:2OZF|rcsb pdb:4JL7|rcsb pdb:4LMM|rcsb pdb:4N6X|rcsb pdb:4PQW|rcsb pdb:4Q3H|rcsb pdb:6RQR|rcsb pdb:4MPA|dip:DIP-29092N	refseq:NP_002600.1|dip:DIP-558N|refseq:XP_011535960.1|refseq:XP_011535961.1|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0035789"(metanephric mesenchymal cell migration)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035793"(positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048839"(inner ear development)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060437"(lung growth)|go:"GO:0060981"(cell migration involved in coronary angiogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071670"(smooth muscle cell chemotaxis)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072262"(metanephric glomerular mesangial cell proliferation involved in metanephros development)|go:"GO:0072277"(metanephric glomerular capillary formation)|go:"GO:0072278"(metanephric comma-shaped body morphogenesis)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027288|interpro:IPR036179|mint:P09619|rcsb pdb:1GQ5|rcsb pdb:1H9O|rcsb pdb:1LWP|rcsb pdb:1SHA|rcsb pdb:2IUI|rcsb pdb:2L6W|rcsb pdb:2PLD|rcsb pdb:2PLE|rcsb pdb:3MJG|reactome:R-HSA-1257604|reactome:R-HSA-186763|reactome:R-HSA-186797|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|ensembl:ENSG00000113721(gene)|ensembl:ENST00000261799(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005017"(platelet-derived growth factor-activated receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008584"(male gonad development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)	-	-	-	figure legend:f2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/27	2014/10/16	rogid:03E30U6coFBcC3BeKOYnInfG/BI9606	rogid:J3OhdjjNQKvgErBLGYg4qBmoMBg9606	intact-crc:294B8536F5245832|rigid:d9IjMBMeaPDOWtgkZgjtTxqyjSo	false	mutation increasing interaction:301-301|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P60484	uniprotkb:O14745	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	intact:EBI-349787|uniprotkb:O43552|uniprotkb:Q86WQ5|ensembl:ENSP00000262613|uniprotkb:B3KY21|intact:EBI-15579389	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:nhrf1_human(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	- (2013)	imex:IM-21392|pubmed:24012959	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8697411|imex:IM-21392-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	refseq:NP_004243.1|ensembl:ENSG00000109062(gene)|ensembl:ENST00000262613(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015185"(gamma-aminobutyric acid transmembrane transporter activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0031982"(vesicle)|go:"GO:0032415"("regulation of sodium:proton antiporter activity")|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044782"(cilium organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|interpro:IPR041489|mint:O14745|rcsb pdb:1G9O|rcsb pdb:1GQ4|rcsb pdb:1GQ5|rcsb pdb:1I92|rcsb pdb:1SGH|rcsb pdb:2D10|rcsb pdb:2JXO|rcsb pdb:2KJD|rcsb pdb:2KRG|rcsb pdb:2M0T|rcsb pdb:2M0U|rcsb pdb:2M0V|rcsb pdb:2OZF|rcsb pdb:4JL7|rcsb pdb:4LMM|rcsb pdb:4N6X|rcsb pdb:4PQW|rcsb pdb:4Q3H|rcsb pdb:6RQR|rcsb pdb:4MPA|dip:DIP-29092N	-	comment:Since the Uniprot Id for Cercopithecus aethiopis is not available we used human Pten because the antibody used in western blot is raised against human protein	-	figure legend:f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/27	2014/10/16	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:03E30U6coFBcC3BeKOYnInfG/BI9606	intact-crc:30A0E18D5399E16E|rigid:0UhQQWSUXUbwMIXnB1F2Zk6XWRc	false	-	mutation decreasing interaction:172-172|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P09619	uniprotkb:O14745	intact:EBI-641237|uniprotkb:Q8N5L4|uniprotkb:B5A957|ensembl:ENSP00000261799	intact:EBI-349787|uniprotkb:O43552|uniprotkb:Q86WQ5|ensembl:ENSP00000262613|uniprotkb:B3KY21|intact:EBI-15579389	psi-mi:pgfrb_human(display_long)|uniprotkb:CD140 antigen-like family member B(gene name synonym)|uniprotkb:PDGFRB(gene name)|psi-mi:PDGFRB(display_short)|uniprotkb:Beta-type platelet-derived growth factor receptor(gene name synonym)|uniprotkb:PDGFR(gene name synonym)|uniprotkb:Platelet-derived growth factor receptor 1(gene name synonym)|uniprotkb:Beta platelet-derived growth factor receptor(gene name synonym)|uniprotkb:PDGFR1(gene name synonym)	psi-mi:nhrf1_human(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	- (2013)	imex:IM-21392|pubmed:24012959	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8691551|imex:IM-21392-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002600.1|dip:DIP-558N|refseq:XP_011535960.1|refseq:XP_011535961.1|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0035789"(metanephric mesenchymal cell migration)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035793"(positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048839"(inner ear development)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060437"(lung growth)|go:"GO:0060981"(cell migration involved in coronary angiogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071670"(smooth muscle cell chemotaxis)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072262"(metanephric glomerular mesangial cell proliferation involved in metanephros development)|go:"GO:0072277"(metanephric glomerular capillary formation)|go:"GO:0072278"(metanephric comma-shaped body morphogenesis)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027288|interpro:IPR036179|mint:P09619|rcsb pdb:1GQ5|rcsb pdb:1H9O|rcsb pdb:1LWP|rcsb pdb:1SHA|rcsb pdb:2IUI|rcsb pdb:2L6W|rcsb pdb:2PLD|rcsb pdb:2PLE|rcsb pdb:3MJG|reactome:R-HSA-1257604|reactome:R-HSA-186763|reactome:R-HSA-186797|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|ensembl:ENSG00000113721(gene)|ensembl:ENST00000261799(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005017"(platelet-derived growth factor-activated receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008584"(male gonad development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)	refseq:NP_004243.1|ensembl:ENSG00000109062(gene)|ensembl:ENST00000262613(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015185"(gamma-aminobutyric acid transmembrane transporter activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0031982"(vesicle)|go:"GO:0032415"("regulation of sodium:proton antiporter activity")|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044782"(cilium organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|interpro:IPR041489|mint:O14745|rcsb pdb:1G9O|rcsb pdb:1GQ4|rcsb pdb:1GQ5|rcsb pdb:1I92|rcsb pdb:1SGH|rcsb pdb:2D10|rcsb pdb:2JXO|rcsb pdb:2KJD|rcsb pdb:2KRG|rcsb pdb:2M0T|rcsb pdb:2M0U|rcsb pdb:2M0V|rcsb pdb:2OZF|rcsb pdb:4JL7|rcsb pdb:4LMM|rcsb pdb:4N6X|rcsb pdb:4PQW|rcsb pdb:4Q3H|rcsb pdb:6RQR|rcsb pdb:4MPA|dip:DIP-29092N	-	-	-	figure legend:f2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/27	2014/10/16	rogid:J3OhdjjNQKvgErBLGYg4qBmoMBg9606	rogid:03E30U6coFBcC3BeKOYnInfG/BI9606	intact-crc:C4B3EF00F36F9AFE|rigid:b1wCKp+1jny7H6QFS/9sYHA81ts	false	binding-associated region:1063-1106|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P09619	uniprotkb:P60484	intact:EBI-641237|uniprotkb:Q8N5L4|uniprotkb:B5A957|ensembl:ENSP00000261799	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	psi-mi:pgfrb_human(display_long)|uniprotkb:CD140 antigen-like family member B(gene name synonym)|uniprotkb:PDGFRB(gene name)|psi-mi:PDGFRB(display_short)|uniprotkb:Beta-type platelet-derived growth factor receptor(gene name synonym)|uniprotkb:PDGFR(gene name synonym)|uniprotkb:Platelet-derived growth factor receptor 1(gene name synonym)|uniprotkb:Beta platelet-derived growth factor receptor(gene name synonym)|uniprotkb:PDGFR1(gene name synonym)	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:"MI:0096"(pull down)	- (2013)	imex:IM-21392|pubmed:24012959	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8691551|imex:IM-21392-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002600.1|dip:DIP-558N|refseq:XP_011535960.1|refseq:XP_011535961.1|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0035789"(metanephric mesenchymal cell migration)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035793"(positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048839"(inner ear development)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060437"(lung growth)|go:"GO:0060981"(cell migration involved in coronary angiogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071670"(smooth muscle cell chemotaxis)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072262"(metanephric glomerular mesangial cell proliferation involved in metanephros development)|go:"GO:0072277"(metanephric glomerular capillary formation)|go:"GO:0072278"(metanephric comma-shaped body morphogenesis)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027288|interpro:IPR036179|mint:P09619|rcsb pdb:1GQ5|rcsb pdb:1H9O|rcsb pdb:1LWP|rcsb pdb:1SHA|rcsb pdb:2IUI|rcsb pdb:2L6W|rcsb pdb:2PLD|rcsb pdb:2PLE|rcsb pdb:3MJG|reactome:R-HSA-1257604|reactome:R-HSA-186763|reactome:R-HSA-186797|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|ensembl:ENSG00000113721(gene)|ensembl:ENST00000261799(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005017"(platelet-derived growth factor-activated receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008584"(male gonad development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	-	-	comment:Since the Uniprot Id for Cercopithecus aethiopis is not available we used human Pten because the antibody used in western blot is raised against human protein	figure legend:f2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/27	2014/10/16	rogid:J3OhdjjNQKvgErBLGYg4qBmoMBg9606	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	intact-crc:C4B3EF00F36F9AFE|rigid:b1wCKp+1jny7H6QFS/9sYHA81ts	false	binding-associated region:1063-1106|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14745	uniprotkb:P60484	intact:EBI-349787|uniprotkb:O43552|uniprotkb:Q86WQ5|ensembl:ENSP00000262613|uniprotkb:B3KY21|intact:EBI-15579389	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	psi-mi:nhrf1_human(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:"MI:0096"(pull down)	- (2013)	imex:IM-21392|pubmed:24012959	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8697424|imex:IM-21392-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004243.1|ensembl:ENSG00000109062(gene)|ensembl:ENST00000262613(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015185"(gamma-aminobutyric acid transmembrane transporter activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0031982"(vesicle)|go:"GO:0032415"("regulation of sodium:proton antiporter activity")|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044782"(cilium organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|interpro:IPR041489|mint:O14745|rcsb pdb:1G9O|rcsb pdb:1GQ4|rcsb pdb:1GQ5|rcsb pdb:1I92|rcsb pdb:1SGH|rcsb pdb:2D10|rcsb pdb:2JXO|rcsb pdb:2KJD|rcsb pdb:2KRG|rcsb pdb:2M0T|rcsb pdb:2M0U|rcsb pdb:2M0V|rcsb pdb:2OZF|rcsb pdb:4JL7|rcsb pdb:4LMM|rcsb pdb:4N6X|rcsb pdb:4PQW|rcsb pdb:4Q3H|rcsb pdb:6RQR|rcsb pdb:4MPA|dip:DIP-29092N	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	-	-	comment:Since the Uniprot Id for Cercopithecus aethiopis is not available we used human Pten because the antibody used in western blot is raised against human protein	figure legend:f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/27	2014/10/16	rogid:03E30U6coFBcC3BeKOYnInfG/BI9606	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	intact-crc:9E818A889E237751|rigid:0UhQQWSUXUbwMIXnB1F2Zk6XWRc	false	glutathione s tranferase tag:?-?|mutation decreasing interaction:301-301	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)