#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35240	uniprotkb:O95835	intact:EBI-1014472|uniprotkb:O95683|uniprotkb:Q8WUJ2|uniprotkb:Q969N0|uniprotkb:Q969Q3|uniprotkb:Q96T30|uniprotkb:Q96T31|uniprotkb:Q96T32|uniprotkb:Q96T33|uniprotkb:Q9BTW3|uniprotkb:Q9UNG9|uniprotkb:Q9UNH3|uniprotkb:Q9UNH4|ensembl:ENSP00000344666	intact:EBI-444209|uniprotkb:Q6PKD0|ensembl:ENSP00000253339|ensembl:ENSP00000437550	psi-mi:merl_human(display_long)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)	psi-mi:lats1_human(display_long)|uniprotkb:Large tumor suppressor homolog 1(gene name synonym)|uniprotkb:WARTS protein kinase(gene name synonym)|uniprotkb:LATS1(gene name)|psi-mi:LATS1(display_short)|uniprotkb:WARTS(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9005158|imex:IM-21729-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000259.1|refseq:NP_057502.2|refseq:NP_861546.1|refseq:NP_861966.1|refseq:NP_861967.1|refseq:NP_861968.1|refseq:NP_861969.1|refseq:NP_861970.1|refseq:NP_861971.1|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007398"(ectoderm development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0016020"(membrane)|go:"GO:0021766"(hippocampus development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035330"(regulation of hippo signaling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0045177"(apical part of cell)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P35240|rcsb pdb:1H4R|rcsb pdb:3U8Z|rcsb pdb:4ZRI|rcsb pdb:4ZRJ|rcsb pdb:6CDS|reactome:R-HSA-2029482|reactome:R-HSA-5627123|dip:DIP-35389N	refseq:NP_004681.1|ensembl:ENSP00000253339|ensembl:ENST00000392273|ensembl:ENSP00000444678|ensembl:ENSP00000437550|refseq:NP_001257448.1|dip:DIP-31516N|ensembl:ENSG00000131023(gene)|ensembl:ENST00000253339(transcript)|ensembl:ENST00000543571(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0000922"(spindle pole)|go:"GO:0001827"(inner cell mass cell fate commitment)|go:"GO:0001828"(inner cell mass cellular morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030496"(midbody)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051301"(cell division)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009060(UBA-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR028741|interpro:IPR042706|rcsb pdb:4ZRK|rcsb pdb:5B5W|rcsb pdb:5BRK|reactome:R-HSA-2028269	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Fig. 4E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/11/12	2014/10/16	rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606	rogid:9HqrE1bBG99E3O2d2ezyRtg2Bd49606	intact-crc:8458CBFFCEAC0E26|rigid:3nwJ2rdTc7l+bhHAlmqNUaXeuuM	false	ha tag:?-?	myc tag:?-?|mutation disrupting interaction strength:77-77,81-81,85-85	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:O95835	uniprotkb:Q13043	intact:EBI-444209|uniprotkb:Q6PKD0|ensembl:ENSP00000253339|ensembl:ENSP00000437550	intact:EBI-367376|uniprotkb:Q15802|uniprotkb:Q4G156|ensembl:ENSP00000361892|uniprotkb:Q5H982|uniprotkb:Q6PD60|uniprotkb:Q9BR32|uniprotkb:Q9NTZ4|uniprotkb:B2RCR8	psi-mi:lats1_human(display_long)|uniprotkb:Large tumor suppressor homolog 1(gene name synonym)|uniprotkb:WARTS protein kinase(gene name synonym)|uniprotkb:LATS1(gene name)|psi-mi:LATS1(display_short)|uniprotkb:WARTS(gene name synonym)	psi-mi:stk4_human(display_long)|uniprotkb:STK4(gene name)|psi-mi:STK4(display_short)|uniprotkb:MST1(gene name synonym)|uniprotkb:STE20-like kinase MST1(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Krs-2(gene name synonym)|uniprotkb:KRS2(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9005250|imex:IM-21729-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004681.1|ensembl:ENSP00000253339|ensembl:ENST00000392273|ensembl:ENSP00000444678|ensembl:ENSP00000437550|refseq:NP_001257448.1|dip:DIP-31516N|ensembl:ENSG00000131023(gene)|ensembl:ENST00000253339(transcript)|ensembl:ENST00000543571(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0000922"(spindle pole)|go:"GO:0001827"(inner cell mass cell fate commitment)|go:"GO:0001828"(inner cell mass cellular morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030496"(midbody)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051301"(cell division)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009060(UBA-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR028741|interpro:IPR042706|rcsb pdb:4ZRK|rcsb pdb:5B5W|rcsb pdb:5BRK|reactome:R-HSA-2028269	ensembl:ENSG00000101109(gene)|ensembl:ENST00000372806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003157"(endocardium development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006273.1|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|refseq:XP_005260590.1|go:"GO:0060800"(regulation of cell differentiation involved in embryonic placenta development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024205|interpro:IPR036674|mint:Q13043|rcsb pdb:2JO8|rcsb pdb:3COM|rcsb pdb:4NR2|rcsb pdb:4OH8|rcsb pdb:5TWG|rcsb pdb:5TWH|rcsb pdb:6YAT|reactome:R-HSA-2028269|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060215"(primitive hemopoiesis)|dip:DIP-32491N	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Supp Fig. 6H|comment:MST/STK41 and LATS1 translocate from the cytoplasm to the plasma membrane in the presence of both  SAV1 and  NF2.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/11/12	2014/10/16	rogid:9HqrE1bBG99E3O2d2ezyRtg2Bd49606	rogid:Z/Uf9T1T/jGvNFWfAkpSf5cQSWY9606	intact-crc:AF4D825B835010B3|rigid:+kH+u00zQ9JBEwed2+VDl1ZrOAM	false	-	flag tag:?-?	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q9VA38	uniprotkb:Q24564	intact:EBI-82717|ensemblmetazoa:FBpp0085082	intact:EBI-180142|uniprotkb:Q24054|uniprotkb:Q8SWY3|ensemblmetazoa:FBpp0074523|ensemblmetazoa:FBpp0311877	psi-mi:warts_drome(display_long)|uniprotkb:wts(gene name)|psi-mi:wts(display_short)|uniprotkb:CG12072(orf name)	psi-mi:merh_drome(display_long)|uniprotkb:Mer(gene name)|psi-mi:Mer(display_short)|uniprotkb:EMR2(gene name synonym)|uniprotkb:CG14228(orf name)|uniprotkb:Ezrin-moesin-radixin 2(gene name synonym)|uniprotkb:Merlin(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9005094|imex:IM-21729-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0011739(gene)|ensemblmetazoa:FBtr0085720(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001708"(cell fate specification)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120080"(obsolete negative regulation of microfilament motor activity)|go:"GO:1904504"(positive regulation of lipophagy)|interpro:IPR000719(Protein kinase, core)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028742|reactome:R-DME-2028269|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045571"(negative regulation of imaginal disc growth)|reactome:R-DME-390089|reactome:R-DME-390098|reactome:R-DME-390150|reactome:R-DME-390178|reactome:R-DME-451806|refseq:NP_733403.1|flybase:FBgn0011739|dip:DIP-20374N	refseq:NP_523413.1|flybase:FBgn0086384|refseq:NP_001285458.1|dip:DIP-17087N|ensemblmetazoa:FBgn0086384(gene)|ensemblmetazoa:FBtr0074754(transcript)|ensemblmetazoa:FBtr0345992(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007112"(male meiosis cytokinesis)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007291"(sperm individualization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009798"(axis specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016006"(Nebenkern)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019094"(pole plasm mRNA localization)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035329"(hippo signaling)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0036375"(Kibra-Ex-Mer complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046669"(regulation of compound eye retinal cell programmed cell death)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0120219"(subapical part of cell)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|rcsb pdb:7EDR|reactome:R-DME-2029482|reactome:R-DME-5627123	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Supp. Fig. 4B|comment:Introduction of the Wts-Ala20Pro-Ile24Thr-Leu28Pro greatly diminished Mer1–600-induced Wts membrane association|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/11/12	2014/10/16	rogid:yBO+BhKuFTQXEj2ywUMv0/brvMw7227	rogid:L3AloQnHvXayDqSyF+QhKptEjjQ7227	intact-crc:23BCC12CEE55FD14|rigid:pYTLtzZIEH54VUjyH3aBaYato34	false	green fluorescent protein tag:?-?|mutation disrupting interaction strength:20-20,24-24,28-28|sufficient binding region:1-50	ha tag:?-?|sufficient binding region:1-600	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q9VA38	uniprotkb:Q24564	intact:EBI-82717|ensemblmetazoa:FBpp0085082	intact:EBI-180142|uniprotkb:Q24054|uniprotkb:Q8SWY3|ensemblmetazoa:FBpp0074523|ensemblmetazoa:FBpp0311877	psi-mi:warts_drome(display_long)|uniprotkb:wts(gene name)|psi-mi:wts(display_short)|uniprotkb:CG12072(orf name)	psi-mi:merh_drome(display_long)|uniprotkb:Mer(gene name)|psi-mi:Mer(display_short)|uniprotkb:EMR2(gene name synonym)|uniprotkb:CG14228(orf name)|uniprotkb:Ezrin-moesin-radixin 2(gene name synonym)|uniprotkb:Merlin(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9075206|imex:IM-21729-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0011739(gene)|ensemblmetazoa:FBtr0085720(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001708"(cell fate specification)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120080"(obsolete negative regulation of microfilament motor activity)|go:"GO:1904504"(positive regulation of lipophagy)|interpro:IPR000719(Protein kinase, core)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028742|reactome:R-DME-2028269|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045571"(negative regulation of imaginal disc growth)|reactome:R-DME-390089|reactome:R-DME-390098|reactome:R-DME-390150|reactome:R-DME-390178|reactome:R-DME-451806|refseq:NP_733403.1|flybase:FBgn0011739|dip:DIP-20374N	refseq:NP_523413.1|flybase:FBgn0086384|refseq:NP_001285458.1|dip:DIP-17087N|ensemblmetazoa:FBgn0086384(gene)|ensemblmetazoa:FBtr0074754(transcript)|ensemblmetazoa:FBtr0345992(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007112"(male meiosis cytokinesis)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007291"(sperm individualization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009798"(axis specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016006"(Nebenkern)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019094"(pole plasm mRNA localization)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035329"(hippo signaling)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0036375"(Kibra-Ex-Mer complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046669"(regulation of compound eye retinal cell programmed cell death)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0120219"(subapical part of cell)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|rcsb pdb:7EDR|reactome:R-DME-2029482|reactome:R-DME-5627123	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Fig 4G,|comment:Introduction of the Wts-Ala20Pro-Ile24Thr-Leu28Pro greatly diminished Mer1–600-induced Wts membrane association|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/11/12	2014/10/16	rogid:yBO+BhKuFTQXEj2ywUMv0/brvMw7227	rogid:L3AloQnHvXayDqSyF+QhKptEjjQ7227	intact-crc:3DD5D6A5AC0DCC72|rigid:pYTLtzZIEH54VUjyH3aBaYato34	false	v5 tag:?-?|mutation disrupting interaction strength:20-20,24-24,28-28	ha tag:?-?|sufficient binding region:1-600	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q8T0S6	uniprotkb:Q9VA38	intact:EBI-101858|uniprotkb:Q9V8W4|ensemblmetazoa:FBpp0085688|ensemblmetazoa:FBpp0304253	intact:EBI-82717|ensemblmetazoa:FBpp0085082	psi-mi:hippo_drome(display_long)|uniprotkb:hpo(gene name)|psi-mi:hpo(display_short)|uniprotkb:dMST(gene name synonym)|uniprotkb:Drosophila homolog of MST1 and MST2(gene name synonym)|uniprotkb:STE20-like kinase MST(gene name synonym)|uniprotkb:CG11228(orf name)	psi-mi:warts_drome(display_long)|uniprotkb:wts(gene name)|psi-mi:wts(display_short)|uniprotkb:CG12072(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8851110|imex:IM-21729-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR036674|mint:Q8T0S6|rcsb pdb:6BN1|reactome:R-DME-390089|reactome:R-DME-390098|reactome:R-DME-390150|reactome:R-DME-451806|interpro:IPR024205|refseq:NP_611427.1|flybase:FBgn0261456|ensemblmetazoa:FBgn0261456(gene)|ensemblmetazoa:FBtr0086500(transcript)|ensemblmetazoa:FBtr0331920(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035265"(organ growth)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0042127"(regulation of cell population proliferation)|refseq:NP_001261092.1|dip:DIP-17921N	ensemblmetazoa:FBgn0011739(gene)|ensemblmetazoa:FBtr0085720(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001708"(cell fate specification)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120080"(obsolete negative regulation of microfilament motor activity)|go:"GO:1904504"(positive regulation of lipophagy)|interpro:IPR000719(Protein kinase, core)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028742|reactome:R-DME-2028269|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045571"(negative regulation of imaginal disc growth)|reactome:R-DME-390089|reactome:R-DME-390098|reactome:R-DME-390150|reactome:R-DME-390178|reactome:R-DME-451806|refseq:NP_733403.1|flybase:FBgn0011739|dip:DIP-20374N	go:"GO:0005886"(plasma membrane)	-	-	comment:Interactors translocate from the cytoplasm to the plasma membrane in the presence of both Sav and Mer1–600|figure legend:Supp Fig. 6G|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/11/12	2014/10/16	rogid:KpEHzTCz7M84Nh6cjyyS55/p+XE7227	rogid:yBO+BhKuFTQXEj2ywUMv0/brvMw7227	intact-crc:BF5A954B866D69AF|rigid:C2J1FPcw969CQEbQahH6GsahyfE	false	myc tag:?-?	v5 tag:?-?	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q24564	uniprotkb:Q9VA38	intact:EBI-180142|uniprotkb:Q24054|uniprotkb:Q8SWY3|ensemblmetazoa:FBpp0074523|ensemblmetazoa:FBpp0311877	intact:EBI-82717|ensemblmetazoa:FBpp0085082	psi-mi:merh_drome(display_long)|uniprotkb:Mer(gene name)|psi-mi:Mer(display_short)|uniprotkb:EMR2(gene name synonym)|uniprotkb:CG14228(orf name)|uniprotkb:Ezrin-moesin-radixin 2(gene name synonym)|uniprotkb:Merlin(gene name synonym)	psi-mi:warts_drome(display_long)|uniprotkb:wts(gene name)|psi-mi:wts(display_short)|uniprotkb:CG12072(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8851166|imex:IM-21729-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523413.1|flybase:FBgn0086384|refseq:NP_001285458.1|dip:DIP-17087N|ensemblmetazoa:FBgn0086384(gene)|ensemblmetazoa:FBtr0074754(transcript)|ensemblmetazoa:FBtr0345992(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007112"(male meiosis cytokinesis)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007291"(sperm individualization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009798"(axis specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016006"(Nebenkern)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019094"(pole plasm mRNA localization)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035329"(hippo signaling)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0036375"(Kibra-Ex-Mer complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046669"(regulation of compound eye retinal cell programmed cell death)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0120219"(subapical part of cell)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|rcsb pdb:7EDR|reactome:R-DME-2029482|reactome:R-DME-5627123	ensemblmetazoa:FBgn0011739(gene)|ensemblmetazoa:FBtr0085720(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001708"(cell fate specification)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120080"(obsolete negative regulation of microfilament motor activity)|go:"GO:1904504"(positive regulation of lipophagy)|interpro:IPR000719(Protein kinase, core)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028742|reactome:R-DME-2028269|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045571"(negative regulation of imaginal disc growth)|reactome:R-DME-390089|reactome:R-DME-390098|reactome:R-DME-390150|reactome:R-DME-390178|reactome:R-DME-451806|refseq:NP_733403.1|flybase:FBgn0011739|dip:DIP-20374N	-	-	-	figure legend:Fig. 6I|agonist:"CHEBI:49703 Latrunculin B, actin polymerization inhibitor"|agonist:C3 Rho GTPase inhibitor|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/11/12	2014/10/16	rogid:L3AloQnHvXayDqSyF+QhKptEjjQ7227	rogid:yBO+BhKuFTQXEj2ywUMv0/brvMw7227	intact-crc:48E237265B6EE77D|rigid:pYTLtzZIEH54VUjyH3aBaYato34	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q95RA8	uniprotkb:Q9VA38	intact:EBI-143689|uniprotkb:Q9VD10|ensemblmetazoa:FBpp0083624|ensemblmetazoa:FBpp0307973|ensemblmetazoa:FBpp0311400	intact:EBI-82717|ensemblmetazoa:FBpp0085082	psi-mi:mob1_drome(display_long)|uniprotkb:Mob as tumor suppressor protein 1(gene name synonym)|uniprotkb:mats(gene name)|psi-mi:mats(display_short)|uniprotkb:Mps one binder kinase activator-like 1(gene name synonym)|uniprotkb:CG13852(orf name)	psi-mi:warts_drome(display_long)|uniprotkb:wts(gene name)|psi-mi:wts(display_short)|uniprotkb:CG12072(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8849812|imex:IM-21729-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287465.1|refseq:NP_651041.3|flybase:FBgn0038965|refseq:NP_001262835.1|dip:DIP-21478N|reactome:R-DME-390150|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035329"(hippo signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR005301(Mob1/phocein)|interpro:IPR036703|mint:Q95RA8|reactome:R-DME-2028269|reactome:R-DME-390089|reactome:R-DME-390098|ensemblmetazoa:FBgn0038965(gene)|ensemblmetazoa:FBtr0084229(transcript)|ensemblmetazoa:FBtr0337044(transcript)|ensemblmetazoa:FBtr0345205(transcript)|go:"GO:0005634"(nucleus)	ensemblmetazoa:FBgn0011739(gene)|ensemblmetazoa:FBtr0085720(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001708"(cell fate specification)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120080"(obsolete negative regulation of microfilament motor activity)|go:"GO:1904504"(positive regulation of lipophagy)|interpro:IPR000719(Protein kinase, core)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028742|reactome:R-DME-2028269|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045571"(negative regulation of imaginal disc growth)|reactome:R-DME-390089|reactome:R-DME-390098|reactome:R-DME-390150|reactome:R-DME-390178|reactome:R-DME-451806|refseq:NP_733403.1|flybase:FBgn0011739|dip:DIP-20374N	-	-	-	figure legend:Supp. Fig. 2A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/11/12	2014/10/16	rogid:A3lIr3nWoKwEmmYOnduxz8tJ07c7227	rogid:yBO+BhKuFTQXEj2ywUMv0/brvMw7227	intact-crc:FFD2275F08EFA62F|rigid:zLRQNCI2z725S5vp1gnolx5PvI4	false	flag tag:?-?	v5 tag:?-?|mutation disrupting interaction strength:708-708	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q24564	uniprotkb:Q24564	intact:EBI-180142|uniprotkb:Q24054|uniprotkb:Q8SWY3|ensemblmetazoa:FBpp0074523|ensemblmetazoa:FBpp0311877	intact:EBI-180142|uniprotkb:Q24054|uniprotkb:Q8SWY3|ensemblmetazoa:FBpp0074523|ensemblmetazoa:FBpp0311877	psi-mi:merh_drome(display_long)|uniprotkb:Mer(gene name)|psi-mi:Mer(display_short)|uniprotkb:EMR2(gene name synonym)|uniprotkb:CG14228(orf name)|uniprotkb:Ezrin-moesin-radixin 2(gene name synonym)|uniprotkb:Merlin(gene name synonym)	psi-mi:merh_drome(display_long)|uniprotkb:Mer(gene name)|psi-mi:Mer(display_short)|uniprotkb:EMR2(gene name synonym)|uniprotkb:CG14228(orf name)|uniprotkb:Ezrin-moesin-radixin 2(gene name synonym)|uniprotkb:Merlin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8850487|imex:IM-21729-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523413.1|flybase:FBgn0086384|refseq:NP_001285458.1|dip:DIP-17087N|ensemblmetazoa:FBgn0086384(gene)|ensemblmetazoa:FBtr0074754(transcript)|ensemblmetazoa:FBtr0345992(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007112"(male meiosis cytokinesis)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007291"(sperm individualization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009798"(axis specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016006"(Nebenkern)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019094"(pole plasm mRNA localization)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035329"(hippo signaling)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0036375"(Kibra-Ex-Mer complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046669"(regulation of compound eye retinal cell programmed cell death)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0120219"(subapical part of cell)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|rcsb pdb:7EDR|reactome:R-DME-2029482|reactome:R-DME-5627123	refseq:NP_523413.1|flybase:FBgn0086384|refseq:NP_001285458.1|dip:DIP-17087N|ensemblmetazoa:FBgn0086384(gene)|ensemblmetazoa:FBtr0074754(transcript)|ensemblmetazoa:FBtr0345992(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007112"(male meiosis cytokinesis)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007291"(sperm individualization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009798"(axis specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016006"(Nebenkern)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019094"(pole plasm mRNA localization)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035329"(hippo signaling)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0036375"(Kibra-Ex-Mer complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046669"(regulation of compound eye retinal cell programmed cell death)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0120219"(subapical part of cell)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|rcsb pdb:7EDR|reactome:R-DME-2029482|reactome:R-DME-5627123	-	-	-	figure legend:Fig. 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/11/12	2014/10/16	rogid:L3AloQnHvXayDqSyF+QhKptEjjQ7227	rogid:L3AloQnHvXayDqSyF+QhKptEjjQ7227	intact-crc:32B068AF2456E2E9|rigid:Hr1IX51AjbxsES6u1y8y9ikN7EQ	false	ha tag:1-375	necessary binding region:601-635|flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q24564	uniprotkb:Q9VA38	intact:EBI-180142|uniprotkb:Q24054|uniprotkb:Q8SWY3|ensemblmetazoa:FBpp0074523|ensemblmetazoa:FBpp0311877	intact:EBI-82717|ensemblmetazoa:FBpp0085082	psi-mi:merh_drome(display_long)|uniprotkb:Mer(gene name)|psi-mi:Mer(display_short)|uniprotkb:EMR2(gene name synonym)|uniprotkb:CG14228(orf name)|uniprotkb:Ezrin-moesin-radixin 2(gene name synonym)|uniprotkb:Merlin(gene name synonym)	psi-mi:warts_drome(display_long)|uniprotkb:wts(gene name)|psi-mi:wts(display_short)|uniprotkb:CG12072(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8850473|imex:IM-21729-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523413.1|flybase:FBgn0086384|refseq:NP_001285458.1|dip:DIP-17087N|ensemblmetazoa:FBgn0086384(gene)|ensemblmetazoa:FBtr0074754(transcript)|ensemblmetazoa:FBtr0345992(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007112"(male meiosis cytokinesis)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007291"(sperm individualization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009798"(axis specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016006"(Nebenkern)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019094"(pole plasm mRNA localization)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035329"(hippo signaling)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0036375"(Kibra-Ex-Mer complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046669"(regulation of compound eye retinal cell programmed cell death)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0120219"(subapical part of cell)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|rcsb pdb:7EDR|reactome:R-DME-2029482|reactome:R-DME-5627123	ensemblmetazoa:FBgn0011739(gene)|ensemblmetazoa:FBtr0085720(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001708"(cell fate specification)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120080"(obsolete negative regulation of microfilament motor activity)|go:"GO:1904504"(positive regulation of lipophagy)|interpro:IPR000719(Protein kinase, core)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028742|reactome:R-DME-2028269|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045571"(negative regulation of imaginal disc growth)|reactome:R-DME-390089|reactome:R-DME-390098|reactome:R-DME-390150|reactome:R-DME-390178|reactome:R-DME-451806|refseq:NP_733403.1|flybase:FBgn0011739|dip:DIP-20374N	-	-	-	figure legend:Fig. 6F, 6H|agonist:"CHEBI:49703 Latrunculin B, actin polymerization inhibitor"|agonist:C3 Rho GTPase inhibitor|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/11/12	2014/10/16	rogid:L3AloQnHvXayDqSyF+QhKptEjjQ7227	rogid:yBO+BhKuFTQXEj2ywUMv0/brvMw7227	intact-crc:266839CA7A3C011C|rigid:pYTLtzZIEH54VUjyH3aBaYato34	false	ha tag:?-?	v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q24564	uniprotkb:Q9VA38	intact:EBI-180142|uniprotkb:Q24054|uniprotkb:Q8SWY3|ensemblmetazoa:FBpp0074523|ensemblmetazoa:FBpp0311877	intact:EBI-82717|ensemblmetazoa:FBpp0085082	psi-mi:merh_drome(display_long)|uniprotkb:Mer(gene name)|psi-mi:Mer(display_short)|uniprotkb:EMR2(gene name synonym)|uniprotkb:CG14228(orf name)|uniprotkb:Ezrin-moesin-radixin 2(gene name synonym)|uniprotkb:Merlin(gene name synonym)	psi-mi:warts_drome(display_long)|uniprotkb:wts(gene name)|psi-mi:wts(display_short)|uniprotkb:CG12072(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8849822|imex:IM-21729-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523413.1|flybase:FBgn0086384|refseq:NP_001285458.1|dip:DIP-17087N|ensemblmetazoa:FBgn0086384(gene)|ensemblmetazoa:FBtr0074754(transcript)|ensemblmetazoa:FBtr0345992(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007112"(male meiosis cytokinesis)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007291"(sperm individualization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009798"(axis specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016006"(Nebenkern)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019094"(pole plasm mRNA localization)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035329"(hippo signaling)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0036375"(Kibra-Ex-Mer complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046669"(regulation of compound eye retinal cell programmed cell death)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0120219"(subapical part of cell)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|rcsb pdb:7EDR|reactome:R-DME-2029482|reactome:R-DME-5627123	ensemblmetazoa:FBgn0011739(gene)|ensemblmetazoa:FBtr0085720(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001708"(cell fate specification)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120080"(obsolete negative regulation of microfilament motor activity)|go:"GO:1904504"(positive regulation of lipophagy)|interpro:IPR000719(Protein kinase, core)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028742|reactome:R-DME-2028269|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045571"(negative regulation of imaginal disc growth)|reactome:R-DME-390089|reactome:R-DME-390098|reactome:R-DME-390150|reactome:R-DME-390178|reactome:R-DME-451806|refseq:NP_733403.1|flybase:FBgn0011739|dip:DIP-20374N	-	-	-	figure legend:Supp. Figs. 2B, 3E/F, 3G|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/11/12	2014/10/16	rogid:L3AloQnHvXayDqSyF+QhKptEjjQ7227	rogid:yBO+BhKuFTQXEj2ywUMv0/brvMw7227	intact-crc:26BDC09DE1E2D368|rigid:pYTLtzZIEH54VUjyH3aBaYato34	false	necessary binding region:325-375|ha tag:?-?	v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q24564	uniprotkb:Q24564	intact:EBI-180142|uniprotkb:Q24054|uniprotkb:Q8SWY3|ensemblmetazoa:FBpp0074523|ensemblmetazoa:FBpp0311877	intact:EBI-180142|uniprotkb:Q24054|uniprotkb:Q8SWY3|ensemblmetazoa:FBpp0074523|ensemblmetazoa:FBpp0311877	psi-mi:merh_drome(display_long)|uniprotkb:Mer(gene name)|psi-mi:Mer(display_short)|uniprotkb:EMR2(gene name synonym)|uniprotkb:CG14228(orf name)|uniprotkb:Ezrin-moesin-radixin 2(gene name synonym)|uniprotkb:Merlin(gene name synonym)	psi-mi:merh_drome(display_long)|uniprotkb:Mer(gene name)|psi-mi:Mer(display_short)|uniprotkb:EMR2(gene name synonym)|uniprotkb:CG14228(orf name)|uniprotkb:Ezrin-moesin-radixin 2(gene name synonym)|uniprotkb:Merlin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8851084|imex:IM-21729-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523413.1|flybase:FBgn0086384|refseq:NP_001285458.1|dip:DIP-17087N|ensemblmetazoa:FBgn0086384(gene)|ensemblmetazoa:FBtr0074754(transcript)|ensemblmetazoa:FBtr0345992(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007112"(male meiosis cytokinesis)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007291"(sperm individualization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009798"(axis specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016006"(Nebenkern)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019094"(pole plasm mRNA localization)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035329"(hippo signaling)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0036375"(Kibra-Ex-Mer complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046669"(regulation of compound eye retinal cell programmed cell death)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0120219"(subapical part of cell)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|rcsb pdb:7EDR|reactome:R-DME-2029482|reactome:R-DME-5627123	refseq:NP_523413.1|flybase:FBgn0086384|refseq:NP_001285458.1|dip:DIP-17087N|ensemblmetazoa:FBgn0086384(gene)|ensemblmetazoa:FBtr0074754(transcript)|ensemblmetazoa:FBtr0345992(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007112"(male meiosis cytokinesis)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007291"(sperm individualization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009798"(axis specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016006"(Nebenkern)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019094"(pole plasm mRNA localization)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035329"(hippo signaling)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0036375"(Kibra-Ex-Mer complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046669"(regulation of compound eye retinal cell programmed cell death)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0120219"(subapical part of cell)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|rcsb pdb:7EDR|reactome:R-DME-2029482|reactome:R-DME-5627123	-	-	-	figure legend:Supp. Fig. 4C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/11/12	2014/10/16	rogid:L3AloQnHvXayDqSyF+QhKptEjjQ7227	rogid:L3AloQnHvXayDqSyF+QhKptEjjQ7227	intact-crc:559B1487FD1D5AA4|rigid:pYTLtzZIEH54VUjyH3aBaYato34	false	sufficient binding region:1-375|ha tag:?-?	sufficient binding region:375-635|flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q24564	uniprotkb:Q9VA38	intact:EBI-180142|uniprotkb:Q24054|uniprotkb:Q8SWY3|ensemblmetazoa:FBpp0074523|ensemblmetazoa:FBpp0311877	intact:EBI-82717|ensemblmetazoa:FBpp0085082	psi-mi:merh_drome(display_long)|uniprotkb:Mer(gene name)|psi-mi:Mer(display_short)|uniprotkb:EMR2(gene name synonym)|uniprotkb:CG14228(orf name)|uniprotkb:Ezrin-moesin-radixin 2(gene name synonym)|uniprotkb:Merlin(gene name synonym)	psi-mi:warts_drome(display_long)|uniprotkb:wts(gene name)|psi-mi:wts(display_short)|uniprotkb:CG12072(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8851084|imex:IM-21729-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523413.1|flybase:FBgn0086384|refseq:NP_001285458.1|dip:DIP-17087N|ensemblmetazoa:FBgn0086384(gene)|ensemblmetazoa:FBtr0074754(transcript)|ensemblmetazoa:FBtr0345992(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007112"(male meiosis cytokinesis)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007291"(sperm individualization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009798"(axis specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016006"(Nebenkern)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019094"(pole plasm mRNA localization)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035329"(hippo signaling)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0036375"(Kibra-Ex-Mer complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046669"(regulation of compound eye retinal cell programmed cell death)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0120219"(subapical part of cell)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|rcsb pdb:7EDR|reactome:R-DME-2029482|reactome:R-DME-5627123	ensemblmetazoa:FBgn0011739(gene)|ensemblmetazoa:FBtr0085720(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001708"(cell fate specification)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120080"(obsolete negative regulation of microfilament motor activity)|go:"GO:1904504"(positive regulation of lipophagy)|interpro:IPR000719(Protein kinase, core)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028742|reactome:R-DME-2028269|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045571"(negative regulation of imaginal disc growth)|reactome:R-DME-390089|reactome:R-DME-390098|reactome:R-DME-390150|reactome:R-DME-390178|reactome:R-DME-451806|refseq:NP_733403.1|flybase:FBgn0011739|dip:DIP-20374N	-	-	-	figure legend:Supp. Fig. 4C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/11/12	2014/10/16	rogid:L3AloQnHvXayDqSyF+QhKptEjjQ7227	rogid:yBO+BhKuFTQXEj2ywUMv0/brvMw7227	intact-crc:559B1487FD1D5AA4|rigid:pYTLtzZIEH54VUjyH3aBaYato34	false	sufficient binding region:1-375|ha tag:?-?	green fluorescent protein tag:?-?|sufficient binding region:1-50	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q24564	uniprotkb:Q9VA38	intact:EBI-180142|uniprotkb:Q24054|uniprotkb:Q8SWY3|ensemblmetazoa:FBpp0074523|ensemblmetazoa:FBpp0311877	intact:EBI-82717|ensemblmetazoa:FBpp0085082	psi-mi:merh_drome(display_long)|uniprotkb:Mer(gene name)|psi-mi:Mer(display_short)|uniprotkb:EMR2(gene name synonym)|uniprotkb:CG14228(orf name)|uniprotkb:Ezrin-moesin-radixin 2(gene name synonym)|uniprotkb:Merlin(gene name synonym)	psi-mi:warts_drome(display_long)|uniprotkb:wts(gene name)|psi-mi:wts(display_short)|uniprotkb:CG12072(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8851072|imex:IM-21729-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523413.1|flybase:FBgn0086384|refseq:NP_001285458.1|dip:DIP-17087N|ensemblmetazoa:FBgn0086384(gene)|ensemblmetazoa:FBtr0074754(transcript)|ensemblmetazoa:FBtr0345992(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007112"(male meiosis cytokinesis)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007291"(sperm individualization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009798"(axis specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016006"(Nebenkern)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019094"(pole plasm mRNA localization)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035329"(hippo signaling)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0036375"(Kibra-Ex-Mer complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046669"(regulation of compound eye retinal cell programmed cell death)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0120219"(subapical part of cell)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|rcsb pdb:7EDR|reactome:R-DME-2029482|reactome:R-DME-5627123	ensemblmetazoa:FBgn0011739(gene)|ensemblmetazoa:FBtr0085720(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001708"(cell fate specification)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120080"(obsolete negative regulation of microfilament motor activity)|go:"GO:1904504"(positive regulation of lipophagy)|interpro:IPR000719(Protein kinase, core)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028742|reactome:R-DME-2028269|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045571"(negative regulation of imaginal disc growth)|reactome:R-DME-390089|reactome:R-DME-390098|reactome:R-DME-390150|reactome:R-DME-390178|reactome:R-DME-451806|refseq:NP_733403.1|flybase:FBgn0011739|dip:DIP-20374N	-	-	-	figure legend:Supp. Fig. 4C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/11/12	2014/10/16	rogid:L3AloQnHvXayDqSyF+QhKptEjjQ7227	rogid:yBO+BhKuFTQXEj2ywUMv0/brvMw7227	intact-crc:C5D90C56BC38B399|rigid:pYTLtzZIEH54VUjyH3aBaYato34	false	ha tag:?-?|sufficient binding region:1-375	green fluorescent protein tag:?-?|sufficient binding region:1-50	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9VA38	uniprotkb:Q24564	intact:EBI-82717|ensemblmetazoa:FBpp0085082	intact:EBI-180142|uniprotkb:Q24054|uniprotkb:Q8SWY3|ensemblmetazoa:FBpp0074523|ensemblmetazoa:FBpp0311877	psi-mi:warts_drome(display_long)|uniprotkb:wts(gene name)|psi-mi:wts(display_short)|uniprotkb:CG12072(orf name)	psi-mi:merh_drome(display_long)|uniprotkb:Mer(gene name)|psi-mi:Mer(display_short)|uniprotkb:EMR2(gene name synonym)|uniprotkb:CG14228(orf name)|uniprotkb:Ezrin-moesin-radixin 2(gene name synonym)|uniprotkb:Merlin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8851184|imex:IM-21729-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0011739(gene)|ensemblmetazoa:FBtr0085720(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001708"(cell fate specification)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007446"(imaginal disc growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120080"(obsolete negative regulation of microfilament motor activity)|go:"GO:1904504"(positive regulation of lipophagy)|interpro:IPR000719(Protein kinase, core)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028742|reactome:R-DME-2028269|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045571"(negative regulation of imaginal disc growth)|reactome:R-DME-390089|reactome:R-DME-390098|reactome:R-DME-390150|reactome:R-DME-390178|reactome:R-DME-451806|refseq:NP_733403.1|flybase:FBgn0011739|dip:DIP-20374N	refseq:NP_523413.1|flybase:FBgn0086384|refseq:NP_001285458.1|dip:DIP-17087N|ensemblmetazoa:FBgn0086384(gene)|ensemblmetazoa:FBtr0074754(transcript)|ensemblmetazoa:FBtr0345992(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007112"(male meiosis cytokinesis)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007291"(sperm individualization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009798"(axis specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016006"(Nebenkern)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019094"(pole plasm mRNA localization)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035329"(hippo signaling)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0036375"(Kibra-Ex-Mer complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046669"(regulation of compound eye retinal cell programmed cell death)|go:"GO:0051307"(meiotic chromosome separation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0120219"(subapical part of cell)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|rcsb pdb:7EDR|reactome:R-DME-2029482|reactome:R-DME-5627123	-	-	-	figure legend:Fig. 3A, 6J, Supp. Fig. 3G|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/11/12	2014/10/16	rogid:yBO+BhKuFTQXEj2ywUMv0/brvMw7227	rogid:L3AloQnHvXayDqSyF+QhKptEjjQ7227	intact-crc:785AE2A3918F8479|rigid:pYTLtzZIEH54VUjyH3aBaYato34	false	v5 tag:?-?	sufficient binding region:1-375|ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8T0S6	uniprotkb:Q9VCR6	intact:EBI-101858|uniprotkb:Q9V8W4|ensemblmetazoa:FBpp0085688|ensemblmetazoa:FBpp0304253	intact:EBI-145004|uniprotkb:Q8MQH6|uniprotkb:Q8T9A6|uniprotkb:Q9VCR5|ensemblmetazoa:FBpp0083749	psi-mi:hippo_drome(display_long)|uniprotkb:hpo(gene name)|psi-mi:hpo(display_short)|uniprotkb:dMST(gene name synonym)|uniprotkb:Drosophila homolog of MST1 and MST2(gene name synonym)|uniprotkb:STE20-like kinase MST(gene name synonym)|uniprotkb:CG11228(orf name)	psi-mi:sav_drome(display_long)|uniprotkb:sav(gene name)|psi-mi:sav(display_short)|uniprotkb:SHRP(gene name synonym)|uniprotkb:CG33193(orf name)|uniprotkb:Shar-pei(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8851151|imex:IM-21729-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR036674|mint:Q8T0S6|rcsb pdb:6BN1|reactome:R-DME-390089|reactome:R-DME-390098|reactome:R-DME-390150|reactome:R-DME-451806|interpro:IPR024205|refseq:NP_611427.1|flybase:FBgn0261456|ensemblmetazoa:FBgn0261456(gene)|ensemblmetazoa:FBtr0086500(transcript)|ensemblmetazoa:FBtr0331920(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035265"(organ growth)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051262"(protein tetramerization)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106037"(apicomedial cortex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011524(SARAH)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0042127"(regulation of cell population proliferation)|refseq:NP_001261092.1|dip:DIP-17921N	refseq:NP_788721.1|flybase:FBgn0053193|dip:DIP-18696N|ensemblmetazoa:FBgn0053193(gene)|ensemblmetazoa:FBtr0084356(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007444"(imaginal disc development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0035329"(hippo signaling)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072002"(Malpighian tubule development)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0106037"(apicomedial cortex)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR011524(SARAH)|interpro:IPR030030|interpro:IPR036020|rcsb pdb:6BN1|reactome:R-DME-390089|reactome:R-DME-390098|reactome:R-DME-390150	-	-	-	figure legend:Fig. 6G|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/11/12	2014/10/16	rogid:KpEHzTCz7M84Nh6cjyyS55/p+XE7227	rogid:/omCdWbZCQT01Iwj5eU7isz1Kr47227	intact-crc:645C31A1287CC4BE|rigid:IY/eIY0l+upAb7fqCoqMGKrc9KU	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35240	uniprotkb:P35240	intact:EBI-1014472|uniprotkb:O95683|uniprotkb:Q8WUJ2|uniprotkb:Q969N0|uniprotkb:Q969Q3|uniprotkb:Q96T30|uniprotkb:Q96T31|uniprotkb:Q96T32|uniprotkb:Q96T33|uniprotkb:Q9BTW3|uniprotkb:Q9UNG9|uniprotkb:Q9UNH3|uniprotkb:Q9UNH4|ensembl:ENSP00000344666	intact:EBI-1014472|uniprotkb:O95683|uniprotkb:Q8WUJ2|uniprotkb:Q969N0|uniprotkb:Q969Q3|uniprotkb:Q96T30|uniprotkb:Q96T31|uniprotkb:Q96T32|uniprotkb:Q96T33|uniprotkb:Q9BTW3|uniprotkb:Q9UNG9|uniprotkb:Q9UNH3|uniprotkb:Q9UNH4|ensembl:ENSP00000344666	psi-mi:merl_human(display_long)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)	psi-mi:merl_human(display_long)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8850569|imex:IM-21729-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000259.1|refseq:NP_057502.2|refseq:NP_861546.1|refseq:NP_861966.1|refseq:NP_861967.1|refseq:NP_861968.1|refseq:NP_861969.1|refseq:NP_861970.1|refseq:NP_861971.1|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007398"(ectoderm development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0016020"(membrane)|go:"GO:0021766"(hippocampus development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035330"(regulation of hippo signaling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0045177"(apical part of cell)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P35240|rcsb pdb:1H4R|rcsb pdb:3U8Z|rcsb pdb:4ZRI|rcsb pdb:4ZRJ|rcsb pdb:6CDS|reactome:R-HSA-2029482|reactome:R-HSA-5627123|dip:DIP-35389N	refseq:NP_000259.1|refseq:NP_057502.2|refseq:NP_861546.1|refseq:NP_861966.1|refseq:NP_861967.1|refseq:NP_861968.1|refseq:NP_861969.1|refseq:NP_861970.1|refseq:NP_861971.1|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007398"(ectoderm development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0016020"(membrane)|go:"GO:0021766"(hippocampus development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035330"(regulation of hippo signaling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0045177"(apical part of cell)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P35240|rcsb pdb:1H4R|rcsb pdb:3U8Z|rcsb pdb:4ZRI|rcsb pdb:4ZRJ|rcsb pdb:6CDS|reactome:R-HSA-2029482|reactome:R-HSA-5627123|dip:DIP-35389N	-	-	-	figure legend:Fig. 3F|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/11/12	2014/10/16	rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606	rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606	intact-crc:37836D907E5ACDC6|rigid:8D7xS7wrg6B9X67g8DahRc+YGZM	false	necessary binding region:560-595|flag tag:?-?	sufficient binding region:1-308|ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35240	uniprotkb:O95835	intact:EBI-1014472|uniprotkb:O95683|uniprotkb:Q8WUJ2|uniprotkb:Q969N0|uniprotkb:Q969Q3|uniprotkb:Q96T30|uniprotkb:Q96T31|uniprotkb:Q96T32|uniprotkb:Q96T33|uniprotkb:Q9BTW3|uniprotkb:Q9UNG9|uniprotkb:Q9UNH3|uniprotkb:Q9UNH4|ensembl:ENSP00000344666	intact:EBI-444209|uniprotkb:Q6PKD0|ensembl:ENSP00000253339|ensembl:ENSP00000437550	psi-mi:merl_human(display_long)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)	psi-mi:lats1_human(display_long)|uniprotkb:Large tumor suppressor homolog 1(gene name synonym)|uniprotkb:WARTS protein kinase(gene name synonym)|uniprotkb:LATS1(gene name)|psi-mi:LATS1(display_short)|uniprotkb:WARTS(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9004892|imex:IM-21729-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000259.1|refseq:NP_057502.2|refseq:NP_861546.1|refseq:NP_861966.1|refseq:NP_861967.1|refseq:NP_861968.1|refseq:NP_861969.1|refseq:NP_861970.1|refseq:NP_861971.1|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007398"(ectoderm development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0016020"(membrane)|go:"GO:0021766"(hippocampus development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035330"(regulation of hippo signaling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0045177"(apical part of cell)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P35240|rcsb pdb:1H4R|rcsb pdb:3U8Z|rcsb pdb:4ZRI|rcsb pdb:4ZRJ|rcsb pdb:6CDS|reactome:R-HSA-2029482|reactome:R-HSA-5627123|dip:DIP-35389N	refseq:NP_004681.1|ensembl:ENSP00000253339|ensembl:ENST00000392273|ensembl:ENSP00000444678|ensembl:ENSP00000437550|refseq:NP_001257448.1|dip:DIP-31516N|ensembl:ENSG00000131023(gene)|ensembl:ENST00000253339(transcript)|ensembl:ENST00000543571(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0000922"(spindle pole)|go:"GO:0001827"(inner cell mass cell fate commitment)|go:"GO:0001828"(inner cell mass cellular morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030496"(midbody)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051301"(cell division)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009060(UBA-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR028741|interpro:IPR042706|rcsb pdb:4ZRK|rcsb pdb:5B5W|rcsb pdb:5BRK|reactome:R-HSA-2028269	-	-	-	figure legend:Fig. 4A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/11/12	2014/10/16	rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606	rogid:9HqrE1bBG99E3O2d2ezyRtg2Bd49606	intact-crc:CD82EFC226541A4D|rigid:3nwJ2rdTc7l+bhHAlmqNUaXeuuM	false	ha tag:?-?	sufficient binding region:1-152|myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O95835	uniprotkb:P35240	intact:EBI-444209|uniprotkb:Q6PKD0|ensembl:ENSP00000253339|ensembl:ENSP00000437550	intact:EBI-1014472|uniprotkb:O95683|uniprotkb:Q8WUJ2|uniprotkb:Q969N0|uniprotkb:Q969Q3|uniprotkb:Q96T30|uniprotkb:Q96T31|uniprotkb:Q96T32|uniprotkb:Q96T33|uniprotkb:Q9BTW3|uniprotkb:Q9UNG9|uniprotkb:Q9UNH3|uniprotkb:Q9UNH4|ensembl:ENSP00000344666	psi-mi:lats1_human(display_long)|uniprotkb:Large tumor suppressor homolog 1(gene name synonym)|uniprotkb:WARTS protein kinase(gene name synonym)|uniprotkb:LATS1(gene name)|psi-mi:LATS1(display_short)|uniprotkb:WARTS(gene name synonym)	psi-mi:merl_human(display_long)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8850518|imex:IM-21729-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004681.1|ensembl:ENSP00000253339|ensembl:ENST00000392273|ensembl:ENSP00000444678|ensembl:ENSP00000437550|refseq:NP_001257448.1|dip:DIP-31516N|ensembl:ENSG00000131023(gene)|ensembl:ENST00000253339(transcript)|ensembl:ENST00000543571(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0000922"(spindle pole)|go:"GO:0001827"(inner cell mass cell fate commitment)|go:"GO:0001828"(inner cell mass cellular morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030496"(midbody)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051301"(cell division)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009060(UBA-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR028741|interpro:IPR042706|rcsb pdb:4ZRK|rcsb pdb:5B5W|rcsb pdb:5BRK|reactome:R-HSA-2028269	refseq:NP_000259.1|refseq:NP_057502.2|refseq:NP_861546.1|refseq:NP_861966.1|refseq:NP_861967.1|refseq:NP_861968.1|refseq:NP_861969.1|refseq:NP_861970.1|refseq:NP_861971.1|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007398"(ectoderm development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0016020"(membrane)|go:"GO:0021766"(hippocampus development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035330"(regulation of hippo signaling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0045177"(apical part of cell)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P35240|rcsb pdb:1H4R|rcsb pdb:3U8Z|rcsb pdb:4ZRI|rcsb pdb:4ZRJ|rcsb pdb:6CDS|reactome:R-HSA-2029482|reactome:R-HSA-5627123|dip:DIP-35389N	-	-	-	figure legend:Fig. 3C, 3G, 3I,  4C, Supp Fig. 3C|comment:The phosphodeficient S518A mutant of NF2 showed greater ability to bind Lats1 compared to the phosphomimetic S518D mutant.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/11/12	2014/10/16	rogid:9HqrE1bBG99E3O2d2ezyRtg2Bd49606	rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606	intact-crc:CC5DFF01972A8F44|rigid:3nwJ2rdTc7l+bhHAlmqNUaXeuuM	false	myc tag:?-?|mutation disrupting interaction strength:77-77,81-81,85-85	ha tag:?-?|sufficient binding region:1-381(IPR018979)|mutation disrupting interaction strength:46-46|mutation disrupting interaction strength:62-62|mutation disrupting interaction strength:64-64|mutation disrupting interaction strength:141-141	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35240-1	uniprotkb:O95835	intact:EBI-1014500|ensembl:ENSP00000344666	intact:EBI-444209|uniprotkb:Q6PKD0|ensembl:ENSP00000253339|ensembl:ENSP00000437550	psi-mi:p35240-1(display_long)|uniprotkb:I(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)	psi-mi:lats1_human(display_long)|uniprotkb:Large tumor suppressor homolog 1(gene name synonym)|uniprotkb:WARTS protein kinase(gene name synonym)|uniprotkb:LATS1(gene name)|psi-mi:LATS1(display_short)|uniprotkb:WARTS(gene name synonym)	psi-mi:"MI:0096"(pull down)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8850551|imex:IM-21729-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript)	refseq:NP_004681.1|ensembl:ENSP00000253339|ensembl:ENST00000392273|ensembl:ENSP00000444678|ensembl:ENSP00000437550|refseq:NP_001257448.1|dip:DIP-31516N|ensembl:ENSG00000131023(gene)|ensembl:ENST00000253339(transcript)|ensembl:ENST00000543571(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0000922"(spindle pole)|go:"GO:0001827"(inner cell mass cell fate commitment)|go:"GO:0001828"(inner cell mass cellular morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030496"(midbody)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051301"(cell division)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009060(UBA-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR028741|interpro:IPR042706|rcsb pdb:4ZRK|rcsb pdb:5B5W|rcsb pdb:5BRK|reactome:R-HSA-2028269	-	-	-	figure legend:Fig. 3E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/12	2014/10/16	rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606	rogid:9HqrE1bBG99E3O2d2ezyRtg2Bd49606	intact-crc:90A75EBA501004BC|rigid:3nwJ2rdTc7l+bhHAlmqNUaXeuuM	false	glutathione s tranferase tag:n-n	myc tag:?-?|mutation disrupting interaction strength:77-77,81-81,85-85	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O95835	uniprotkb:P35240	intact:EBI-444209|uniprotkb:Q6PKD0|ensembl:ENSP00000253339|ensembl:ENSP00000437550	intact:EBI-1014472|uniprotkb:O95683|uniprotkb:Q8WUJ2|uniprotkb:Q969N0|uniprotkb:Q969Q3|uniprotkb:Q96T30|uniprotkb:Q96T31|uniprotkb:Q96T32|uniprotkb:Q96T33|uniprotkb:Q9BTW3|uniprotkb:Q9UNG9|uniprotkb:Q9UNH3|uniprotkb:Q9UNH4|ensembl:ENSP00000344666	psi-mi:lats1_human(display_long)|uniprotkb:Large tumor suppressor homolog 1(gene name synonym)|uniprotkb:WARTS protein kinase(gene name synonym)|uniprotkb:LATS1(gene name)|psi-mi:LATS1(display_short)|uniprotkb:WARTS(gene name synonym)	psi-mi:merl_human(display_long)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yin et al. (2013)	imex:IM-21729|pubmed:24012335	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8850541|imex:IM-21729-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004681.1|ensembl:ENSP00000253339|ensembl:ENST00000392273|ensembl:ENSP00000444678|ensembl:ENSP00000437550|refseq:NP_001257448.1|dip:DIP-31516N|ensembl:ENSG00000131023(gene)|ensembl:ENST00000253339(transcript)|ensembl:ENST00000543571(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0000922"(spindle pole)|go:"GO:0001827"(inner cell mass cell fate commitment)|go:"GO:0001828"(inner cell mass cellular morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030496"(midbody)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051301"(cell division)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009060(UBA-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR028741|interpro:IPR042706|rcsb pdb:4ZRK|rcsb pdb:5B5W|rcsb pdb:5BRK|reactome:R-HSA-2028269	refseq:NP_000259.1|refseq:NP_057502.2|refseq:NP_861546.1|refseq:NP_861966.1|refseq:NP_861967.1|refseq:NP_861968.1|refseq:NP_861969.1|refseq:NP_861970.1|refseq:NP_861971.1|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007398"(ectoderm development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0016020"(membrane)|go:"GO:0021766"(hippocampus development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035330"(regulation of hippo signaling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0045177"(apical part of cell)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P35240|rcsb pdb:1H4R|rcsb pdb:3U8Z|rcsb pdb:4ZRI|rcsb pdb:4ZRJ|rcsb pdb:6CDS|reactome:R-HSA-2029482|reactome:R-HSA-5627123|dip:DIP-35389N	-	-	-	figure legend:Fig. 3D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/11/12	2014/10/16	rogid:9HqrE1bBG99E3O2d2ezyRtg2Bd49606	rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606	intact-crc:D0B16A3109701878|rigid:3nwJ2rdTc7l+bhHAlmqNUaXeuuM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)