#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99IB8-PRO_0000045598	uniprotkb:Q9Y6A9	intact:EBI-6901421|intact:EBI-6928831	intact:EBI-8852196|uniprotkb:B3KNF8|uniprotkb:Q9BVW1|ensembl:ENSP00000233025|uniprotkb:X6R2S6	psi-mi:q99ib8-pro_0000045598(display_long)	psi-mi:spcs1_human(display_long)|uniprotkb:SPCS1(gene name)|psi-mi:SPCS1(display_short)|uniprotkb:SPC12(gene name synonym)|uniprotkb:Microsomal signal peptidase 12 kDa subunit(gene name synonym)|uniprotkb:HSPC033(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Suzuki et al. (2013)	pubmed:24009510|imex:IM-25858	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8852194|imex:IM-25858-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6674379(chain-parent)	refseq:NP_054760.3|ensembl:ENSG00000114902(gene)|ensembl:ENST00000233025(transcript)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0019068"(virion assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR009542(Microsomal signal peptidase 12 kDa subunit)|interpro:IPR037713|reactome:R-HSA-1799339|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-422085	-	chain-seq-start:814|chain-seq-end:1030	-	figure legend:Results|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/11/15	2019/10/18	rogid:wDqxnwGoKrkL9adV5W65GK43rW4356411	rogid:X9U6jCa1mT05K+3QABDJZAMKr/I9606	intact-crc:4E0951E556F1B0B8|rigid:6aRp8cR8XYZXJG7wAVOP1NXETgM	false	cub:?-?	nub:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Y6A9	uniprotkb:Q99IB8-PRO_0000045598	intact:EBI-8852196|uniprotkb:B3KNF8|uniprotkb:Q9BVW1|ensembl:ENSP00000233025|uniprotkb:X6R2S6	intact:EBI-6901421|intact:EBI-6928831	psi-mi:spcs1_human(display_long)|uniprotkb:SPCS1(gene name)|psi-mi:SPCS1(display_short)|uniprotkb:SPC12(gene name synonym)|uniprotkb:Microsomal signal peptidase 12 kDa subunit(gene name synonym)|uniprotkb:HSPC033(orf name)	psi-mi:q99ib8-pro_0000045598(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Suzuki et al. (2013)	pubmed:24009510|imex:IM-25858	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8852234|imex:IM-25858-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054760.3|ensembl:ENSG00000114902(gene)|ensembl:ENST00000233025(transcript)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0019068"(virion assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR009542(Microsomal signal peptidase 12 kDa subunit)|interpro:IPR037713|reactome:R-HSA-1799339|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-422085	intact:EBI-6674379(chain-parent)	-	-	chain-seq-start:814|chain-seq-end:1030	figure legend:Fig. 1B and 1E|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/15	2019/10/18	rogid:X9U6jCa1mT05K+3QABDJZAMKr/I9606	rogid:wDqxnwGoKrkL9adV5W65GK43rW4356411	intact-crc:7EA792AAE3CD9CE3|rigid:6aRp8cR8XYZXJG7wAVOP1NXETgM	false	myc tag:c-c|sufficient binding region:110-169	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99IB8-PRO_0000045598	uniprotkb:Q9Y6A9	intact:EBI-6901421|intact:EBI-6928831	intact:EBI-8852196|uniprotkb:B3KNF8|uniprotkb:Q9BVW1|ensembl:ENSP00000233025|uniprotkb:X6R2S6	psi-mi:q99ib8-pro_0000045598(display_long)	psi-mi:spcs1_human(display_long)|uniprotkb:SPCS1(gene name)|psi-mi:SPCS1(display_short)|uniprotkb:SPC12(gene name synonym)|uniprotkb:Microsomal signal peptidase 12 kDa subunit(gene name synonym)|uniprotkb:HSPC033(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Suzuki et al. (2013)	pubmed:24009510|imex:IM-25858	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8873871|imex:IM-25858-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6674379(chain-parent)	refseq:NP_054760.3|ensembl:ENSG00000114902(gene)|ensembl:ENST00000233025(transcript)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0019068"(virion assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR009542(Microsomal signal peptidase 12 kDa subunit)|interpro:IPR037713|reactome:R-HSA-1799339|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-422085	-	chain-seq-start:814|chain-seq-end:1030	-	figure legend:Fig. 1B and 1F|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/15	2019/10/18	rogid:wDqxnwGoKrkL9adV5W65GK43rW4356411	rogid:X9U6jCa1mT05K+3QABDJZAMKr/I9606	intact-crc:F8E45AE8DDA02FDD|rigid:6aRp8cR8XYZXJG7wAVOP1NXETgM	false	flag tag:n-n|sufficient binding region:50-94	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y6A9	uniprotkb:Q99IB8-PRO_0000045598	intact:EBI-8852196|uniprotkb:B3KNF8|uniprotkb:Q9BVW1|ensembl:ENSP00000233025|uniprotkb:X6R2S6	intact:EBI-6901421|intact:EBI-6928831	psi-mi:spcs1_human(display_long)|uniprotkb:SPCS1(gene name)|psi-mi:SPCS1(display_short)|uniprotkb:SPC12(gene name synonym)|uniprotkb:Microsomal signal peptidase 12 kDa subunit(gene name synonym)|uniprotkb:HSPC033(orf name)	psi-mi:q99ib8-pro_0000045598(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Suzuki et al. (2013)	pubmed:24009510|imex:IM-25858	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8852255|imex:IM-25858-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054760.3|ensembl:ENSG00000114902(gene)|ensembl:ENST00000233025(transcript)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0019068"(virion assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR009542(Microsomal signal peptidase 12 kDa subunit)|interpro:IPR037713|reactome:R-HSA-1799339|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-422085	intact:EBI-6674379(chain-parent)	-	-	chain-seq-start:814|chain-seq-end:1030	figure legend:Fig. 1C|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2013/11/15	2019/10/18	rogid:X9U6jCa1mT05K+3QABDJZAMKr/I9606	rogid:wDqxnwGoKrkL9adV5W65GK43rW4356411	intact-crc:79CF9975F9503377|rigid:6aRp8cR8XYZXJG7wAVOP1NXETgM	false	myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y6A9	uniprotkb:Q99IB8-PRO_0000045598	intact:EBI-8852196|uniprotkb:B3KNF8|uniprotkb:Q9BVW1|ensembl:ENSP00000233025|uniprotkb:X6R2S6	intact:EBI-6901421|intact:EBI-6928831	psi-mi:spcs1_human(display_long)|uniprotkb:SPCS1(gene name)|psi-mi:SPCS1(display_short)|uniprotkb:SPC12(gene name synonym)|uniprotkb:Microsomal signal peptidase 12 kDa subunit(gene name synonym)|uniprotkb:HSPC033(orf name)	psi-mi:q99ib8-pro_0000045598(display_long)	psi-mi:"MI:0813"(proximity ligation assay)	Suzuki et al. (2013)	pubmed:24009510|imex:IM-25858	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8852276|imex:IM-25858-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054760.3|ensembl:ENSG00000114902(gene)|ensembl:ENST00000233025(transcript)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0019068"(virion assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR009542(Microsomal signal peptidase 12 kDa subunit)|interpro:IPR037713|reactome:R-HSA-1799339|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-422085	intact:EBI-6674379(chain-parent)	go:"GO:0030430"(host cell cytoplasm)	-	chain-seq-start:814|chain-seq-end:1030	figure legend:Fig. 1G|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/15	2019/10/18	rogid:X9U6jCa1mT05K+3QABDJZAMKr/I9606	rogid:wDqxnwGoKrkL9adV5W65GK43rW4356411	intact-crc:945C81781A937221|rigid:6aRp8cR8XYZXJG7wAVOP1NXETgM	false	myc tag:c-c|v5 tag:n-n|binding-associated region:110-169	flag tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Y6A9	uniprotkb:Q99IB8-PRO_0000045596	intact:EBI-8852196|uniprotkb:B3KNF8|uniprotkb:Q9BVW1|ensembl:ENSP00000233025|uniprotkb:X6R2S6	intact:EBI-6901449|intact:EBI-6927909	psi-mi:spcs1_human(display_long)|uniprotkb:SPCS1(gene name)|psi-mi:SPCS1(display_short)|uniprotkb:SPC12(gene name synonym)|uniprotkb:Microsomal signal peptidase 12 kDa subunit(gene name synonym)|uniprotkb:HSPC033(orf name)	psi-mi:q99ib8-pro_0000045596(display_long)	psi-mi:"MI:0813"(proximity ligation assay)	Suzuki et al. (2013)	pubmed:24009510|imex:IM-25858	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8852291|imex:IM-25858-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054760.3|ensembl:ENSG00000114902(gene)|ensembl:ENST00000233025(transcript)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0019068"(virion assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR009542(Microsomal signal peptidase 12 kDa subunit)|interpro:IPR037713|reactome:R-HSA-1799339|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-422085	intact:EBI-6674379(chain-parent)	-	-	chain-seq-start:384|chain-seq-end:750	figure legend:Fig. S3|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/15	2019/10/18	rogid:X9U6jCa1mT05K+3QABDJZAMKr/I9606	rogid:d8l1EuWXqUdXoYmKoeOf+YKqJ4w356411	intact-crc:523EAE6233C51672|rigid:1cIvXVCe8grOGm+fgIjtgLMJhVw	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Y6A9	uniprotkb:Q99IB8-PRO_0000045598	intact:EBI-8852196|uniprotkb:B3KNF8|uniprotkb:Q9BVW1|ensembl:ENSP00000233025|uniprotkb:X6R2S6	intact:EBI-6901421|intact:EBI-6928831	psi-mi:spcs1_human(display_long)|uniprotkb:SPCS1(gene name)|psi-mi:SPCS1(display_short)|uniprotkb:SPC12(gene name synonym)|uniprotkb:Microsomal signal peptidase 12 kDa subunit(gene name synonym)|uniprotkb:HSPC033(orf name)	psi-mi:q99ib8-pro_0000045598(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Suzuki et al. (2013)	pubmed:24009510|imex:IM-25858	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8873953|imex:IM-25858-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054760.3|ensembl:ENSG00000114902(gene)|ensembl:ENST00000233025(transcript)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0019068"(virion assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR009542(Microsomal signal peptidase 12 kDa subunit)|interpro:IPR037713|reactome:R-HSA-1799339|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-422085	intact:EBI-6674379(chain-parent)	-	-	chain-seq-start:814|chain-seq-end:1030	figure legend:Fig. 6A|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/15	2019/10/18	rogid:X9U6jCa1mT05K+3QABDJZAMKr/I9606	rogid:wDqxnwGoKrkL9adV5W65GK43rW4356411	intact-crc:13EDFD6AF49CAB5D|rigid:9GIFXp7KQJ6pSDvjepDOTVccvdU	false	myc tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y6A9	uniprotkb:Q99IB8-PRO_0000045596	intact:EBI-8852196|uniprotkb:B3KNF8|uniprotkb:Q9BVW1|ensembl:ENSP00000233025|uniprotkb:X6R2S6	intact:EBI-6901449|intact:EBI-6927909	psi-mi:spcs1_human(display_long)|uniprotkb:SPCS1(gene name)|psi-mi:SPCS1(display_short)|uniprotkb:SPC12(gene name synonym)|uniprotkb:Microsomal signal peptidase 12 kDa subunit(gene name synonym)|uniprotkb:HSPC033(orf name)	psi-mi:q99ib8-pro_0000045596(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Suzuki et al. (2013)	pubmed:24009510|imex:IM-25858	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8873953|imex:IM-25858-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054760.3|ensembl:ENSG00000114902(gene)|ensembl:ENST00000233025(transcript)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0019068"(virion assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR009542(Microsomal signal peptidase 12 kDa subunit)|interpro:IPR037713|reactome:R-HSA-1799339|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-422085	intact:EBI-6674379(chain-parent)	-	-	chain-seq-start:384|chain-seq-end:750	figure legend:Fig. 6A|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/15	2019/10/18	rogid:X9U6jCa1mT05K+3QABDJZAMKr/I9606	rogid:d8l1EuWXqUdXoYmKoeOf+YKqJ4w356411	intact-crc:13EDFD6AF49CAB5D|rigid:9GIFXp7KQJ6pSDvjepDOTVccvdU	false	myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99IB8-PRO_0000045598	uniprotkb:Q99IB8-PRO_0000045596	intact:EBI-6901421|intact:EBI-6928831	intact:EBI-6901449|intact:EBI-6927909	psi-mi:q99ib8-pro_0000045598(display_long)	psi-mi:q99ib8-pro_0000045596(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Suzuki et al. (2013)	pubmed:24009510|imex:IM-25858	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8873995|imex:IM-25858-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6674379(chain-parent)	intact:EBI-6674379(chain-parent)	-	chain-seq-start:814|chain-seq-end:1030	chain-seq-start:384|chain-seq-end:750	figure legend:Fig. 6A|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/15	2017/09/02	rogid:wDqxnwGoKrkL9adV5W65GK43rW4356411	rogid:d8l1EuWXqUdXoYmKoeOf+YKqJ4w356411	intact-crc:D603E1366118952E|rigid:bajBlqUsxnOAlCNeeoZ+2LUOr/4	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y6A9	uniprotkb:Q99IB8-PRO_0000045597	intact:EBI-8852196|uniprotkb:B3KNF8|uniprotkb:Q9BVW1|ensembl:ENSP00000233025|uniprotkb:X6R2S6	intact:EBI-8772829	psi-mi:spcs1_human(display_long)|uniprotkb:SPCS1(gene name)|psi-mi:SPCS1(display_short)|uniprotkb:SPC12(gene name synonym)|uniprotkb:Microsomal signal peptidase 12 kDa subunit(gene name synonym)|uniprotkb:HSPC033(orf name)	psi-mi:q99ib8-pro_0000045597(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Suzuki et al. (2013)	pubmed:24009510|imex:IM-25858	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8873949|imex:IM-25858-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054760.3|ensembl:ENSG00000114902(gene)|ensembl:ENST00000233025(transcript)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0019068"(virion assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR009542(Microsomal signal peptidase 12 kDa subunit)|interpro:IPR037713|reactome:R-HSA-1799339|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-422085	intact:EBI-6674379(chain-parent)	-	-	chain-seq-start:751|chain-seq-end:813	figure legend:Fig. 6B, 6C and S2|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/15	2019/10/18	rogid:X9U6jCa1mT05K+3QABDJZAMKr/I9606	rogid:g1N1nFD9PcDZYobytpfV14YG0no356411	intact-crc:DBB0C1BFED0EE37D|rigid:zjSePSH4892e7/mHgwuxVDal7e8	false	myc tag:c-c|sufficient binding region:109-169	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y6A9	uniprotkb:Q99IB8-PRO_0000045596	intact:EBI-8852196|uniprotkb:B3KNF8|uniprotkb:Q9BVW1|ensembl:ENSP00000233025|uniprotkb:X6R2S6	intact:EBI-6901449|intact:EBI-6927909	psi-mi:spcs1_human(display_long)|uniprotkb:SPCS1(gene name)|psi-mi:SPCS1(display_short)|uniprotkb:SPC12(gene name synonym)|uniprotkb:Microsomal signal peptidase 12 kDa subunit(gene name synonym)|uniprotkb:HSPC033(orf name)	psi-mi:q99ib8-pro_0000045596(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Suzuki et al. (2013)	pubmed:24009510|imex:IM-25858	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8873949|imex:IM-25858-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054760.3|ensembl:ENSG00000114902(gene)|ensembl:ENST00000233025(transcript)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0019068"(virion assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR009542(Microsomal signal peptidase 12 kDa subunit)|interpro:IPR037713|reactome:R-HSA-1799339|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-422085	intact:EBI-6674379(chain-parent)	-	-	chain-seq-start:384|chain-seq-end:750	figure legend:Fig. 6B, 6C and S2|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/15	2019/10/18	rogid:X9U6jCa1mT05K+3QABDJZAMKr/I9606	rogid:d8l1EuWXqUdXoYmKoeOf+YKqJ4w356411	intact-crc:DBB0C1BFED0EE37D|rigid:zjSePSH4892e7/mHgwuxVDal7e8	false	myc tag:c-c|sufficient binding region:109-169	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99IB8-PRO_0000045598	uniprotkb:Q9Y6A9	intact:EBI-6901421|intact:EBI-6928831	intact:EBI-8852196|uniprotkb:B3KNF8|uniprotkb:Q9BVW1|ensembl:ENSP00000233025|uniprotkb:X6R2S6	psi-mi:q99ib8-pro_0000045598(display_long)	psi-mi:spcs1_human(display_long)|uniprotkb:SPCS1(gene name)|psi-mi:SPCS1(display_short)|uniprotkb:SPC12(gene name synonym)|uniprotkb:Microsomal signal peptidase 12 kDa subunit(gene name synonym)|uniprotkb:HSPC033(orf name)	psi-mi:"MI:0090"(protein complementation assay)	Suzuki et al. (2013)	pubmed:24009510|imex:IM-25858	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8852304|imex:IM-25858-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6674379(chain-parent)	refseq:NP_054760.3|ensembl:ENSG00000114902(gene)|ensembl:ENST00000233025(transcript)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0019068"(virion assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR009542(Microsomal signal peptidase 12 kDa subunit)|interpro:IPR037713|reactome:R-HSA-1799339|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-422085	-	chain-seq-start:814|chain-seq-end:1030	-	figure legend:Fig. 1H|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/15	2019/10/18	rogid:wDqxnwGoKrkL9adV5W65GK43rW4356411	rogid:X9U6jCa1mT05K+3QABDJZAMKr/I9606	intact-crc:9BF7E48C9D464A4B|rigid:6aRp8cR8XYZXJG7wAVOP1NXETgM	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q99IB8-PRO_0000045596	uniprotkb:Q9Y6A9	intact:EBI-6901449|intact:EBI-6927909	intact:EBI-8852196|uniprotkb:B3KNF8|uniprotkb:Q9BVW1|ensembl:ENSP00000233025|uniprotkb:X6R2S6	psi-mi:q99ib8-pro_0000045596(display_long)	psi-mi:spcs1_human(display_long)|uniprotkb:SPCS1(gene name)|psi-mi:SPCS1(display_short)|uniprotkb:SPC12(gene name synonym)|uniprotkb:Microsomal signal peptidase 12 kDa subunit(gene name synonym)|uniprotkb:HSPC033(orf name)	psi-mi:"MI:0090"(protein complementation assay)	Suzuki et al. (2013)	pubmed:24009510|imex:IM-25858	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8852314|imex:IM-25858-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6674379(chain-parent)	refseq:NP_054760.3|ensembl:ENSG00000114902(gene)|ensembl:ENST00000233025(transcript)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0019068"(virion assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR009542(Microsomal signal peptidase 12 kDa subunit)|interpro:IPR037713|reactome:R-HSA-1799339|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-422085	-	chain-seq-start:384|chain-seq-end:750	-	figure legend:Fig. S3|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/15	2019/10/18	rogid:d8l1EuWXqUdXoYmKoeOf+YKqJ4w356411	rogid:X9U6jCa1mT05K+3QABDJZAMKr/I9606	intact-crc:DA0A389AF33204FF|rigid:1cIvXVCe8grOGm+fgIjtgLMJhVw	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)