#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P19332	uniprotkb:A6NAR8	intact:EBI-7080713|uniprotkb:Q63567|uniprotkb:Q63677|uniprotkb:Q9QW06|intact:MINT-1037362	intact:EBI-8755852	psi-mi:tau_rat(display_long)|uniprotkb:Mapt(gene name)|psi-mi:Mapt(display_short)|uniprotkb:Mtapt(gene name synonym)|uniprotkb:Tau(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)	psi-mi:a6nar8_mouse(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakanishi et al. (2013)	pubmed:23986251|imex:IM-21390	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8755850|imex:IM-21390-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0003677"(DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006915"(apoptotic process)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008017"(microtubule binding)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032387"(negative regulation of intracellular transport)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034399"(nuclear periphery)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0044304"(main axon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045298"(tubulin complex)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048675"(axon extension)|go:"GO:0050808"(synapse organization)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051028"(mRNA transport)|go:"GO:0051087"(chaperone binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097386"(glial cell projection)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0099609"(microtubule lateral binding)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001084(Tubulin-binding Tau protein)|interpro:IPR002955(Tau protein)|go:"GO:1901216"(positive regulation of neuron death)|rgd:69329|dip:DIP-41779N|reactome:R-RNO-264870	interpro:IPR006907(Protein of unknown function DUF622)|refseq:NP_001278023.1	-	comment:mint|function:"Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization"	-	figure legend:7B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10114(rat-cortical_neuron)|taxid:10114(Rat cortical Neurons)	-	2013/09/09	2014/10/16	rogid:65t+kCG5P0Iv7QNaptNW3GSjsEA10116	rogid:qjAPpT9SudhPVd5iYODD+5FAaF410090	intact-crc:28C2857315B9FE25|rigid:yIsPxGBsVrapMAZWHZGh+UJhIII	false	-	enhanced green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19332	uniprotkb:A6NAR8	intact:EBI-7080713|uniprotkb:Q63567|uniprotkb:Q63677|uniprotkb:Q9QW06|intact:MINT-1037362	intact:EBI-8755852	psi-mi:tau_rat(display_long)|uniprotkb:Mapt(gene name)|psi-mi:Mapt(display_short)|uniprotkb:Mtapt(gene name synonym)|uniprotkb:Tau(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)	psi-mi:a6nar8_mouse(display_long)	psi-mi:"MI:0813"(proximity ligation assay)	Nakanishi et al. (2013)	pubmed:23986251|imex:IM-21390	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8755880|imex:IM-21390-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0003677"(DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0006915"(apoptotic process)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008017"(microtubule binding)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032387"(negative regulation of intracellular transport)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034399"(nuclear periphery)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0044304"(main axon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045298"(tubulin complex)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048675"(axon extension)|go:"GO:0050808"(synapse organization)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051028"(mRNA transport)|go:"GO:0051087"(chaperone binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097386"(glial cell projection)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0099609"(microtubule lateral binding)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001084(Tubulin-binding Tau protein)|interpro:IPR002955(Tau protein)|go:"GO:1901216"(positive regulation of neuron death)|rgd:69329|dip:DIP-41779N|reactome:R-RNO-264870	interpro:IPR006907(Protein of unknown function DUF622)|refseq:NP_001278023.1	go:"GO:0030425"(dendrite)	comment:mint|function:"Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization"	-	figure legend:7C|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10114(rat-cortical_neuron)|taxid:10114(Rat cortical Neurons)	-	2013/09/09	2014/10/16	rogid:65t+kCG5P0Iv7QNaptNW3GSjsEA10116	rogid:qjAPpT9SudhPVd5iYODD+5FAaF410090	intact-crc:3F32DF1F84F84FF9|rigid:yIsPxGBsVrapMAZWHZGh+UJhIII	false	-	enhanced green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:A6NAR8	uniprotkb:A6NAR8	intact:EBI-8755852	intact:EBI-8755852	psi-mi:a6nar8_mouse(display_long)	psi-mi:a6nar8_mouse(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakanishi et al. (2013)	pubmed:23986251|imex:IM-21390	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8755943|imex:IM-21390-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR006907(Protein of unknown function DUF622)|refseq:NP_001278023.1	interpro:IPR006907(Protein of unknown function DUF622)|refseq:NP_001278023.1	-	-	-	figure legend:9E|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/09/09	2014/10/16	rogid:qjAPpT9SudhPVd5iYODD+5FAaF410090	rogid:qjAPpT9SudhPVd5iYODD+5FAaF410090	intact-crc:ABC9F31A18B7D8D8|rigid:w//zGaPmTtcYsHy0C7LArPbM6JA	false	flag tag:?-?	enhanced green fluorescent protein tag:n-n|necessary binding region:31-80	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)