#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8NFA2-3 uniprotkb:P13498 intact:EBI-20557410|ensembl:ENSP00000348435 intact:EBI-986058|uniprotkb:Q14090|uniprotkb:Q9BR72|ensembl:ENSP00000261623 psi-mi:q8nfa2-3(display_long)|uniprotkb:Nox-organizing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 5(gene name synonym)|uniprotkb:NADPH oxidase regulatory protein(gene name synonym)|uniprotkb:Nox organizer 1(gene name synonym)|uniprotkb:NOXO1(gene name)|psi-mi:NOXO1(display_short)|uniprotkb:P41NOX(gene name synonym)|uniprotkb:SH3PXD5(gene name synonym)|uniprotkb:NOXO1beta(isoform synonym) psi-mi:cy24a_human(display_long)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym)|uniprotkb:Neutrophil cytochrome b 22 kDa polypeptide(gene name synonym)|uniprotkb:p22-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) alpha chain"(gene name synonym)|uniprotkb:Cytochrome b558 subunit alpha(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase light chain subunit(gene name synonym)|uniprotkb:CYBA(gene name)|psi-mi:CYBA(display_short) psi-mi:"MI:0096"(pull down) Yamamoto et al. (2013) pubmed:23957209|imex:IM-21407 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8755064|imex:IM-21407-3 - - psi-mi:"MI:0919"(acceptor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000196408(gene)|ensembl:ENST00000356120(transcript)|intact:EBI-7130806(isoform-parent) ensembl:ENSG00000051523(gene)|ensembl:ENST00000261623(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003106"(negative regulation of glomerular filtration by angiotensin)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014823"(response to activity)|go:"GO:0014895"(smooth muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017004"(cytochrome complex assembly)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904845"(cellular response to L-glutamine)|interpro:IPR007732(Cytochrome b558 alpha-subunit)|mint:P13498|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_000092.2|dip:DIP-37650N - - - figure legend:f4d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/09/05 2018/05/03 rogid:ariBxsYipkvhLXah7Ne5n76UljM9606 rogid:FviZIB2lWLr0GrH9y2gxAA6mgCg9606 intact-crc:53D79658D6AB0AE8|rigid:UuEzZkRBR06fTci79h4q3P9tIL8 false glutathione s tranferase tag:?-?|mutation decreasing interaction:195-195|binding-associated region:154-292 maltose binding protein tag:?-?|mutation disrupting interaction:156-156 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q8NFA2-3 uniprotkb:P13498 intact:EBI-20557410|ensembl:ENSP00000348435 intact:EBI-986058|uniprotkb:Q14090|uniprotkb:Q9BR72|ensembl:ENSP00000261623 psi-mi:q8nfa2-3(display_long)|uniprotkb:Nox-organizing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 5(gene name synonym)|uniprotkb:NADPH oxidase regulatory protein(gene name synonym)|uniprotkb:Nox organizer 1(gene name synonym)|uniprotkb:NOXO1(gene name)|psi-mi:NOXO1(display_short)|uniprotkb:P41NOX(gene name synonym)|uniprotkb:SH3PXD5(gene name synonym)|uniprotkb:NOXO1beta(isoform synonym) psi-mi:cy24a_human(display_long)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym)|uniprotkb:Neutrophil cytochrome b 22 kDa polypeptide(gene name synonym)|uniprotkb:p22-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) alpha chain"(gene name synonym)|uniprotkb:Cytochrome b558 subunit alpha(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase light chain subunit(gene name synonym)|uniprotkb:CYBA(gene name)|psi-mi:CYBA(display_short) psi-mi:"MI:0096"(pull down) Yamamoto et al. (2013) pubmed:23957209|imex:IM-21407 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8755047|imex:IM-21407-2 - - psi-mi:"MI:0919"(acceptor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000196408(gene)|ensembl:ENST00000356120(transcript)|intact:EBI-7130806(isoform-parent) ensembl:ENSG00000051523(gene)|ensembl:ENST00000261623(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003106"(negative regulation of glomerular filtration by angiotensin)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014823"(response to activity)|go:"GO:0014895"(smooth muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017004"(cytochrome complex assembly)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904845"(cellular response to L-glutamine)|interpro:IPR007732(Cytochrome b558 alpha-subunit)|mint:P13498|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_000092.2|dip:DIP-37650N - - - figure legend:f4d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/09/05 2018/05/03 rogid:ariBxsYipkvhLXah7Ne5n76UljM9606 rogid:FviZIB2lWLr0GrH9y2gxAA6mgCg9606 intact-crc:F9A635EAD9DBDC6A|rigid:UuEzZkRBR06fTci79h4q3P9tIL8 false mutation decreasing interaction:195-195|binding-associated region:154-292|glutathione s tranferase tag:?-? mutation disrupting interaction:156-156|maltose binding protein tag:?-? - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q8NFA2 uniprotkb:Q8NFA2-3 intact:EBI-7130806|ensembl:ENSP00000380450|uniprotkb:Q86YM1|intact:MINT-7147796|uniprotkb:Q8NFA3|uniprotkb:Q96B73 intact:EBI-20557410|ensembl:ENSP00000348435 psi-mi:noxo1_human(display_long)|uniprotkb:NOXO1(gene name)|psi-mi:NOXO1(display_short)|uniprotkb:P41NOX(gene name synonym)|uniprotkb:SH3PXD5(gene name synonym)|uniprotkb:Nox-organizing protein 1(gene name synonym)|uniprotkb:Nox organizer 1(gene name synonym)|uniprotkb:NADPH oxidase regulatory protein(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 5(gene name synonym) psi-mi:q8nfa2-3(display_long)|uniprotkb:Nox-organizing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 5(gene name synonym)|uniprotkb:NADPH oxidase regulatory protein(gene name synonym)|uniprotkb:Nox organizer 1(gene name synonym)|uniprotkb:NOXO1(gene name)|psi-mi:NOXO1(display_short)|uniprotkb:P41NOX(gene name synonym)|uniprotkb:SH3PXD5(gene name synonym)|uniprotkb:NOXO1beta(isoform synonym) psi-mi:"MI:0096"(pull down) Yamamoto et al. (2013) pubmed:23957209|imex:IM-21407 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8755593|imex:IM-21407-9 - - psi-mi:"MI:0500"(biological role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000196408(gene)|ensembl:ENST00000397280(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060263"(regulation of respiratory burst)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR035758|interpro:IPR036028|interpro:IPR036871|mint:Q8NFA2|rcsb pdb:2L73|reactome:R-HSA-5668599|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_751908.1|refseq:NP_751907.1|refseq:NP_001254650.1|refseq:NP_653204.1|refseq:XP_005255156.1|refseq:XP_016878416.1|refseq:XP_016878417.1 ensembl:ENSG00000196408(gene)|ensembl:ENST00000356120(transcript)|intact:EBI-7130806(isoform-parent) - comment:mint|comment:homomint - figure legend:f6d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/09/05 2018/05/03 rogid:QJb5bSxtmpD723eCNye534Zifws9606 rogid:ariBxsYipkvhLXah7Ne5n76UljM9606 intact-crc:08F36DFD6030670B|rigid:/a+b9JxNMiFSLKgoeS8iBPhN0g8 false binding-associated region:321-371|maltose binding protein tag:?-? glutathione s tranferase tag:?-?|binding-associated region:154-292|mutation disrupting interaction:197-197 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q8NFA2-3 uniprotkb:Q86UR1 intact:EBI-20557410|ensembl:ENSP00000348435 intact:EBI-949814|ensembl:ENSP00000507846|uniprotkb:O60533|uniprotkb:Q29VU9|uniprotkb:Q29VV0|uniprotkb:Q2TAM1|uniprotkb:Q8IUS3 psi-mi:q8nfa2-3(display_long)|uniprotkb:Nox-organizing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 5(gene name synonym)|uniprotkb:NADPH oxidase regulatory protein(gene name synonym)|uniprotkb:Nox organizer 1(gene name synonym)|uniprotkb:NOXO1(gene name)|psi-mi:NOXO1(display_short)|uniprotkb:P41NOX(gene name synonym)|uniprotkb:SH3PXD5(gene name synonym)|uniprotkb:NOXO1beta(isoform synonym) psi-mi:noxa1_human(display_long)|uniprotkb:NCF2-like protein(gene name synonym)|uniprotkb:Antigen NY-CO-31(gene name synonym)|uniprotkb:P67phox-like factor(gene name synonym)|uniprotkb:p51-nox(gene name synonym)|uniprotkb:NOXA1(gene name)|psi-mi:NOXA1(display_short)|uniprotkb:P51NOX(gene name synonym) psi-mi:"MI:0096"(pull down) Yamamoto et al. (2013) pubmed:23957209|imex:IM-21407 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8755575|imex:IM-21407-8 - - psi-mi:"MI:0919"(acceptor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000196408(gene)|ensembl:ENST00000356120(transcript)|intact:EBI-7130806(isoform-parent) ensembl:ENSG00000188747(gene)|ensembl:ENST00000683555(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0060263"(regulation of respiratory burst)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR034899|interpro:IPR036028|reactome:R-HSA-5668599|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_006638.1|refseq:NP_001242996.1|refseq:NP_001242997.1 - - - figure legend:f6e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/09/05 2018/05/03 rogid:ariBxsYipkvhLXah7Ne5n76UljM9606 rogid:b9yF3AbB0i4feLHukYPjiT5jlJg9606 intact-crc:F5AE843140FCC41D|rigid:b4OLoTljZoGyvwgHdw43Q+k6QSc false mutation increasing interaction:341-341|maltose binding protein tag:?-?|binding-associated region:321-371 binding-associated region:399-458|glutathione s tranferase tag:?-? - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P13498 uniprotkb:Q8NFA2-3 intact:EBI-986058|uniprotkb:Q14090|uniprotkb:Q9BR72|ensembl:ENSP00000261623 intact:EBI-20557410|ensembl:ENSP00000348435 psi-mi:cy24a_human(display_long)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym)|uniprotkb:Neutrophil cytochrome b 22 kDa polypeptide(gene name synonym)|uniprotkb:p22-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) alpha chain"(gene name synonym)|uniprotkb:Cytochrome b558 subunit alpha(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase light chain subunit(gene name synonym)|uniprotkb:CYBA(gene name)|psi-mi:CYBA(display_short) psi-mi:q8nfa2-3(display_long)|uniprotkb:Nox-organizing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 5(gene name synonym)|uniprotkb:NADPH oxidase regulatory protein(gene name synonym)|uniprotkb:Nox organizer 1(gene name synonym)|uniprotkb:NOXO1(gene name)|psi-mi:NOXO1(display_short)|uniprotkb:P41NOX(gene name synonym)|uniprotkb:SH3PXD5(gene name synonym)|uniprotkb:NOXO1beta(isoform synonym) psi-mi:"MI:0096"(pull down) Yamamoto et al. (2013) pubmed:23957209|imex:IM-21407 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8755030|imex:IM-21407-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0919"(acceptor) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000051523(gene)|ensembl:ENST00000261623(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003106"(negative regulation of glomerular filtration by angiotensin)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014823"(response to activity)|go:"GO:0014895"(smooth muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017004"(cytochrome complex assembly)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904845"(cellular response to L-glutamine)|interpro:IPR007732(Cytochrome b558 alpha-subunit)|mint:P13498|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_000092.2|dip:DIP-37650N ensembl:ENSG00000196408(gene)|ensembl:ENST00000356120(transcript)|intact:EBI-7130806(isoform-parent) - - - figure legend:f4d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/09/05 2018/05/03 rogid:FviZIB2lWLr0GrH9y2gxAA6mgCg9606 rogid:ariBxsYipkvhLXah7Ne5n76UljM9606 intact-crc:E9DFE3B8C122BE48|rigid:UuEzZkRBR06fTci79h4q3P9tIL8 false maltose binding protein tag:?-?|mutation disrupting interaction:156-156 glutathione s tranferase tag:?-?|mutation decreasing interaction:195-195|binding-associated region:154-292 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q86UR1 uniprotkb:Q8NFA2-3 intact:EBI-949814|ensembl:ENSP00000507846|uniprotkb:O60533|uniprotkb:Q29VU9|uniprotkb:Q29VV0|uniprotkb:Q2TAM1|uniprotkb:Q8IUS3 intact:EBI-20557410|ensembl:ENSP00000348435 psi-mi:noxa1_human(display_long)|uniprotkb:NCF2-like protein(gene name synonym)|uniprotkb:Antigen NY-CO-31(gene name synonym)|uniprotkb:P67phox-like factor(gene name synonym)|uniprotkb:p51-nox(gene name synonym)|uniprotkb:NOXA1(gene name)|psi-mi:NOXA1(display_short)|uniprotkb:P51NOX(gene name synonym) psi-mi:q8nfa2-3(display_long)|uniprotkb:Nox-organizing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 5(gene name synonym)|uniprotkb:NADPH oxidase regulatory protein(gene name synonym)|uniprotkb:Nox organizer 1(gene name synonym)|uniprotkb:NOXO1(gene name)|psi-mi:NOXO1(display_short)|uniprotkb:P41NOX(gene name synonym)|uniprotkb:SH3PXD5(gene name synonym)|uniprotkb:NOXO1beta(isoform synonym) psi-mi:"MI:0096"(pull down) Yamamoto et al. (2013) pubmed:23957209|imex:IM-21407 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8755515|imex:IM-21407-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0919"(acceptor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188747(gene)|ensembl:ENST00000683555(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0060263"(regulation of respiratory burst)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR034899|interpro:IPR036028|reactome:R-HSA-5668599|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_006638.1|refseq:NP_001242996.1|refseq:NP_001242997.1 ensembl:ENSG00000196408(gene)|ensembl:ENST00000356120(transcript)|intact:EBI-7130806(isoform-parent) - - - figure legend:f6b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/09/05 2018/05/03 rogid:b9yF3AbB0i4feLHukYPjiT5jlJg9606 rogid:ariBxsYipkvhLXah7Ne5n76UljM9606 intact-crc:249F443865C01985|rigid:b4OLoTljZoGyvwgHdw43Q+k6QSc false binding-associated region:399-458|glutathione s tranferase tag:?-?|mutation disrupting interaction:436-436 maltose binding protein tag:?-?|binding-associated region:154-371|mutation disrupting interaction:341-341 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q8NFA2-3 uniprotkb:Q86UR1 intact:EBI-20557410|ensembl:ENSP00000348435 intact:EBI-949814|ensembl:ENSP00000507846|uniprotkb:O60533|uniprotkb:Q29VU9|uniprotkb:Q29VV0|uniprotkb:Q2TAM1|uniprotkb:Q8IUS3 psi-mi:q8nfa2-3(display_long)|uniprotkb:Nox-organizing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 5(gene name synonym)|uniprotkb:NADPH oxidase regulatory protein(gene name synonym)|uniprotkb:Nox organizer 1(gene name synonym)|uniprotkb:NOXO1(gene name)|psi-mi:NOXO1(display_short)|uniprotkb:P41NOX(gene name synonym)|uniprotkb:SH3PXD5(gene name synonym)|uniprotkb:NOXO1beta(isoform synonym) psi-mi:noxa1_human(display_long)|uniprotkb:NCF2-like protein(gene name synonym)|uniprotkb:Antigen NY-CO-31(gene name synonym)|uniprotkb:P67phox-like factor(gene name synonym)|uniprotkb:p51-nox(gene name synonym)|uniprotkb:NOXA1(gene name)|psi-mi:NOXA1(display_short)|uniprotkb:P51NOX(gene name synonym) psi-mi:"MI:0096"(pull down) Yamamoto et al. (2013) pubmed:23957209|imex:IM-21407 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8755496|imex:IM-21407-4 - - psi-mi:"MI:0919"(acceptor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000196408(gene)|ensembl:ENST00000356120(transcript)|intact:EBI-7130806(isoform-parent) ensembl:ENSG00000188747(gene)|ensembl:ENST00000683555(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0060263"(regulation of respiratory burst)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR034899|interpro:IPR036028|reactome:R-HSA-5668599|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_006638.1|refseq:NP_001242996.1|refseq:NP_001242997.1 - - - figure legend:f6a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/09/05 2018/05/03 rogid:ariBxsYipkvhLXah7Ne5n76UljM9606 rogid:b9yF3AbB0i4feLHukYPjiT5jlJg9606 intact-crc:249D943865C01985|rigid:b4OLoTljZoGyvwgHdw43Q+k6QSc false maltose binding protein tag:?-?|binding-associated region:321-371|mutation disrupting interaction:343-343 glutathione s tranferase tag:?-?|binding-associated region:399-458 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q86UR1 uniprotkb:Q8NFA2-3 intact:EBI-949814|ensembl:ENSP00000507846|uniprotkb:O60533|uniprotkb:Q29VU9|uniprotkb:Q29VV0|uniprotkb:Q2TAM1|uniprotkb:Q8IUS3 intact:EBI-20557410|ensembl:ENSP00000348435 psi-mi:noxa1_human(display_long)|uniprotkb:NCF2-like protein(gene name synonym)|uniprotkb:Antigen NY-CO-31(gene name synonym)|uniprotkb:P67phox-like factor(gene name synonym)|uniprotkb:p51-nox(gene name synonym)|uniprotkb:NOXA1(gene name)|psi-mi:NOXA1(display_short)|uniprotkb:P51NOX(gene name synonym) psi-mi:q8nfa2-3(display_long)|uniprotkb:Nox-organizing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 5(gene name synonym)|uniprotkb:NADPH oxidase regulatory protein(gene name synonym)|uniprotkb:Nox organizer 1(gene name synonym)|uniprotkb:NOXO1(gene name)|psi-mi:NOXO1(display_short)|uniprotkb:P41NOX(gene name synonym)|uniprotkb:SH3PXD5(gene name synonym)|uniprotkb:NOXO1beta(isoform synonym) psi-mi:"MI:0096"(pull down) Yamamoto et al. (2013) pubmed:23957209|imex:IM-21407 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8755535|imex:IM-21407-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0919"(acceptor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188747(gene)|ensembl:ENST00000683555(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0060263"(regulation of respiratory burst)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR034899|interpro:IPR036028|reactome:R-HSA-5668599|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_006638.1|refseq:NP_001242996.1|refseq:NP_001242997.1 ensembl:ENSG00000196408(gene)|ensembl:ENST00000356120(transcript)|intact:EBI-7130806(isoform-parent) - - - figure legend:f6c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/09/05 2018/05/03 rogid:b9yF3AbB0i4feLHukYPjiT5jlJg9606 rogid:ariBxsYipkvhLXah7Ne5n76UljM9606 intact-crc:A8B3C3A2EEB49A51|rigid:b4OLoTljZoGyvwgHdw43Q+k6QSc false glutathione s tranferase tag:?-?|binding-associated region:399-458|mutation disrupting interaction:436-436 maltose binding protein tag:?-?|binding-associated region:321-371 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q8NFA2-3 uniprotkb:Q86UR1 intact:EBI-20557410|ensembl:ENSP00000348435 intact:EBI-949814|ensembl:ENSP00000507846|uniprotkb:O60533|uniprotkb:Q29VU9|uniprotkb:Q29VV0|uniprotkb:Q2TAM1|uniprotkb:Q8IUS3 psi-mi:q8nfa2-3(display_long)|uniprotkb:Nox-organizing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 5(gene name synonym)|uniprotkb:NADPH oxidase regulatory protein(gene name synonym)|uniprotkb:Nox organizer 1(gene name synonym)|uniprotkb:NOXO1(gene name)|psi-mi:NOXO1(display_short)|uniprotkb:P41NOX(gene name synonym)|uniprotkb:SH3PXD5(gene name synonym)|uniprotkb:NOXO1beta(isoform synonym) psi-mi:noxa1_human(display_long)|uniprotkb:NCF2-like protein(gene name synonym)|uniprotkb:Antigen NY-CO-31(gene name synonym)|uniprotkb:P67phox-like factor(gene name synonym)|uniprotkb:p51-nox(gene name synonym)|uniprotkb:NOXA1(gene name)|psi-mi:NOXA1(display_short)|uniprotkb:P51NOX(gene name synonym) psi-mi:"MI:0096"(pull down) Yamamoto et al. (2013) pubmed:23957209|imex:IM-21407 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8755555|imex:IM-21407-7 - - psi-mi:"MI:0919"(acceptor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000196408(gene)|ensembl:ENST00000356120(transcript)|intact:EBI-7130806(isoform-parent) ensembl:ENSG00000188747(gene)|ensembl:ENST00000683555(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0060263"(regulation of respiratory burst)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR034899|interpro:IPR036028|reactome:R-HSA-5668599|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_006638.1|refseq:NP_001242996.1|refseq:NP_001242997.1 - - - figure legend:f6e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/09/05 2018/05/03 rogid:ariBxsYipkvhLXah7Ne5n76UljM9606 rogid:b9yF3AbB0i4feLHukYPjiT5jlJg9606 intact-crc:FC07A3F6EB809FD5|rigid:b4OLoTljZoGyvwgHdw43Q+k6QSc false binding-associated region:321-371|maltose binding protein tag:?-?|mutation increasing interaction:341-341 glutathione s tranferase tag:?-?|binding-associated region:399-458 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)