#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P98073	uniprotkb:O35305	intact:EBI-6914845|ensembl:ENSP00000284885|uniprotkb:Q2NKL7	intact:EBI-647362|uniprotkb:Q8VCT7|ensembl:ENSMUSP00000027559	psi-mi:entk_human(display_long)|uniprotkb:TMPRSS15(gene name)|psi-mi:TMPRSS15(display_short)|uniprotkb:ENTK(gene name synonym)|uniprotkb:Enterokinase(gene name synonym)|uniprotkb:PRSS7(gene name synonym)|uniprotkb:Serine protease 7(gene name synonym)|uniprotkb:Transmembrane protease serine 15(gene name synonym)	psi-mi:tnr11_mouse(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:Tnfrsf11a(gene name)|psi-mi:Tnfrsf11a(display_short)|uniprotkb:Rank(gene name synonym)	psi-mi:"MI:0990"(cleavage assay)	Zhao et al. (2013)	pubmed:23954298|imex:IM-21010	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6914842|imex:IM-21010-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000154646(gene)|ensembl:ENST00000284885(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005903"(brush border)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000082(SEA)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011163(Peptidase S1A, enteropeptidase)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR018114|interpro:IPR023415|interpro:IPR033116|interpro:IPR035914|interpro:IPR036055|interpro:IPR036364|interpro:IPR036772|interpro:IPR043504|rcsb pdb:4DGJ|rcsb pdb:6ZOV|refseq:NP_002763.2|uniprot:P98073(primary-reference)	refseq:NP_033425.3|dip:DIP-48710N|ensembl:ENSMUSG00000026321(gene)|ensembl:ENSMUST00000027559(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|rcsb pdb:3ME2|rcsb pdb:3ME4|rcsb pdb:3QBQ|rcsb pdb:4GIQ|rcsb pdb:5BNQ|reactome:R-MMU-5668541|reactome:R-MMU-5676594	-	-	-	figure legend:f2a f2d f2e f2f f2g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/04	2019/02/08	rogid:gfjwzLcYCFeQJRX8opS057AvWbM9606	rogid:i4ywqFZctL9NJvryst9My52nv4810090	intact-crc:BA9406E038858FF4|rigid:UiJ7nYcsj9XNPk9FUeh/PUKqh6g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P98073	uniprotkb:Q9Y6Q6	intact:EBI-6914845|ensembl:ENSP00000284885|uniprotkb:Q2NKL7	intact:EBI-525675|ensembl:ENSP00000465500|uniprotkb:I4EC39|uniprotkb:I4EC36|uniprotkb:I4EC38|uniprotkb:I7JE63|uniprotkb:N0GVH0|uniprotkb:Q59EP9	psi-mi:entk_human(display_long)|uniprotkb:TMPRSS15(gene name)|psi-mi:TMPRSS15(display_short)|uniprotkb:ENTK(gene name synonym)|uniprotkb:Enterokinase(gene name synonym)|uniprotkb:PRSS7(gene name synonym)|uniprotkb:Serine protease 7(gene name synonym)|uniprotkb:Transmembrane protease serine 15(gene name synonym)	psi-mi:tnr11_human(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:TNFRSF11A(gene name)|psi-mi:TNFRSF11A(display_short)|uniprotkb:RANK(gene name synonym)	psi-mi:"MI:0990"(cleavage assay)	Zhao et al. (2013)	pubmed:23954298|imex:IM-21010	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6914852|imex:IM-21010-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000154646(gene)|ensembl:ENST00000284885(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005903"(brush border)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000082(SEA)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011163(Peptidase S1A, enteropeptidase)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR018114|interpro:IPR023415|interpro:IPR033116|interpro:IPR035914|interpro:IPR036055|interpro:IPR036364|interpro:IPR036772|interpro:IPR043504|rcsb pdb:4DGJ|rcsb pdb:6ZOV|refseq:NP_002763.2|uniprot:P98073(primary-reference)	refseq:NP_001257878.1|refseq:NP_001257879.1|refseq:NP_001265197.1|refseq:NP_003830.1|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|mint:Q9Y6Q6|rcsb pdb:1LB5|reactome:R-HSA-5668541|reactome:R-HSA-5676594|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|ensembl:ENSG00000141655(gene)|ensembl:ENST00000586569(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|refseq:NP_001257880.1	-	-	-	figure legend:f2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/04	2014/10/16	rogid:gfjwzLcYCFeQJRX8opS057AvWbM9606	rogid:MfAijsRPOfdjCfKTkrV196sCZzw9606	intact-crc:9E4CD1B0A28D3D53|rigid:81Fx87c083o7+nJZ3HFBVAYklzY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)