#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35207	uniprotkb:P17883	intact:EBI-1851|uniprotkb:Q06047|uniprotkb:D6VZ33|ensemblfungi:YLR398C	intact:EBI-1861|uniprotkb:Q06585|ensemblfungi:YPR189W	psi-mi:ski2_yeast(display_long)|uniprotkb:SKI2(gene name)|psi-mi:SKI2(display_short)|uniprotkb:YLR398C(locus name)|uniprotkb:L8084.17(orf name)|uniprotkb:Superkiller protein 2(gene name synonym)	psi-mi:ski3_yeast(display_long)|uniprotkb:SKI3(gene name)|psi-mi:SKI3(display_short)|uniprotkb:P9677.7(orf name)|uniprotkb:YPR189W(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Halbach et al. (2013)	pubmed:23953113|imex:IM-21726	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8805891|imex:IM-21726-1|wwpdb:4BUJ	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000004390|refseq:NP_013502.3|dip:DIP-5887N|mint:P35207|ensemblfungi:YLR398C(gene)|ensemblfungi:YLR398C_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0051607"(defense response to virus)|go:"GO:0055087"(Ski complex)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012961(DSH, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016438(RNA helicase, ATP-dependent, SK12/DOB1)|interpro:IPR025696|interpro:IPR027417|interpro:IPR040801|rcsb pdb:4A4K|rcsb pdb:4A4Z|rcsb pdb:4BUJ|rcsb pdb:5MC6|reactome:R-SCE-429958	sgd:S000006393|refseq:NP_015515.1|dip:DIP-6379N|mint:P17883|ensemblfungi:YPR189W(gene)|ensemblfungi:YPR189W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0051607"(defense response to virus)|go:"GO:0055087"(Ski complex)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039226|interpro:IPR040962|rcsb pdb:4BUJ|rcsb pdb:5MC6|reactome:R-SCE-429958	-	crc64:7CCD36CFC0DF8C32	crc64:18FFF78D7CA5A6E4	3d-resolution:3.7A|3d-r-factors:Rworking = 0.23 Rfree = 0.26|figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/22	2014/10/16	rogid:qXGrLWktU2dryGHkNINEmcsbmFI559292	rogid:wjMKcbtN38crXFX7hQgZ0Bz475Y559292	intact-crc:FE0893906610D009|rigid:nsj0l2HfxwwY3IPSrf26a7ZdObg	false	sufficient binding region:1086-1287,1-834	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35207	uniprotkb:Q02793	intact:EBI-1851|uniprotkb:Q06047|uniprotkb:D6VZ33|ensemblfungi:YLR398C	intact:EBI-17260|uniprotkb:D6VTU2|ensemblfungi:YGL213C	psi-mi:ski2_yeast(display_long)|uniprotkb:SKI2(gene name)|psi-mi:SKI2(display_short)|uniprotkb:YLR398C(locus name)|uniprotkb:L8084.17(orf name)|uniprotkb:Superkiller protein 2(gene name synonym)	psi-mi:ski8_yeast(display_long)|uniprotkb:YGL213C(locus name)|uniprotkb:SKI8(gene name)|psi-mi:SKI8(display_short)|uniprotkb:REC103(gene name synonym)|uniprotkb:Superkiller protein 8(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Halbach et al. (2013)	pubmed:23953113|imex:IM-21726	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8805891|imex:IM-21726-1|wwpdb:4BUJ	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000004390|refseq:NP_013502.3|dip:DIP-5887N|mint:P35207|ensemblfungi:YLR398C(gene)|ensemblfungi:YLR398C_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0051607"(defense response to virus)|go:"GO:0055087"(Ski complex)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012961(DSH, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016438(RNA helicase, ATP-dependent, SK12/DOB1)|interpro:IPR025696|interpro:IPR027417|interpro:IPR040801|rcsb pdb:4A4K|rcsb pdb:4A4Z|rcsb pdb:4BUJ|rcsb pdb:5MC6|reactome:R-SCE-429958	refseq:NP_011302.1|sgd:S000003181|ensemblfungi:YGL213C(gene)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0034622"|go:"GO:0051607"(defense response to virus)|go:"GO:0055087"(Ski complex)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|rcsb pdb:1S4U|rcsb pdb:1SQ9|rcsb pdb:4BUJ|rcsb pdb:5MC6|reactome:R-SCE-429958|reactome:R-SCE-674695|reactome:R-SCE-75955|ensemblfungi:YGL213C_mRNA(transcript)|dip:DIP-1653N|mint:Q02793	-	crc64:7CCD36CFC0DF8C32	crc64:C5E7B9D2268F9727	3d-resolution:3.7A|3d-r-factors:Rworking = 0.23 Rfree = 0.26|figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/22	2014/10/16	rogid:qXGrLWktU2dryGHkNINEmcsbmFI559292	rogid:6K6FJYcctdlT1321Nv6pOnQPwq8559292	intact-crc:FE0893906610D009|rigid:nsj0l2HfxwwY3IPSrf26a7ZdObg	false	sufficient binding region:1086-1287,1-834	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-8817559	wwpdb:4BUJ	-	intact:EBI-1371206|intenz:3.6.4.13|rhea:"RHEA:13065"	psi-mi:"c(uc)28"(display_short)|psi-mi:EBI-8817559(display_long)	psi-mi:ski_yeast(display_short)|psi-mi:4BUJ(display_long)|intact:SKI complex(complex recommended name)|intact:"SKI2:SKI3:SKI8"(complex systematic name)|intact:Ski2p-Ski3p-Ski8p complex(complex synonym)	psi-mi:"MI:1183"(nuclease footprinting)	Halbach et al. (2013)	pubmed:23953113|imex:IM-21726	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8817593|imex:IM-21726-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0320"(ribonucleic acid)	psi-mi:"MI:1302"(stable complex)	-	intact:EBI-1371221(exp-evidence)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0055087"(Ski complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0003723"(RNA binding)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0006402"(mRNA catabolic process)|complex portal:CPX-1040(complex-primary)|evidence ontology:"ECO:0000353"	go:"GO:0003723"(RNA binding)	-	curated-complex:"Central component of the 3'-5' cytoplasmic mRNA degradation pathway which interacts with Ski7 (Q08491) to mediate degradation by the exosome. The Ski complex appears to thread RNAs directly to the exosome, coupling the helicase and the exoribonuclease through a continuous RNA channel."|complex-properties:Ski3 forms an array of 33 TPR motifs organized in N-terminal and C-terminal arms. The C-terminal arm of Ski3 and the two Ski8 subunits position the helicase core of Ski2 centrally within the complex, enhancing RNA binding. The Ski3 N-terminal arm and the Ski2 insertion domain allosterically modulate the ATPase and helicase activities of the complex.   MW = 370-380kDa|complex-assembly:Heterotetramer	figure legend:Fig. 1C, 4C|comment:ADP-beryllium fluoride was required for this interaction to occur.|comment:Mutation of SKI3 resulted in a complex containing less SKI8 than wild-type so it is assumed SKI8 plays a role in RNA binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/22	2016/06/28	-	-	intact-crc:CADFEC2C7CCB6619	false	32p radiolabel:?-?	mutation decreasing interaction strength:1412-1413,1416-1416	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P35207	uniprotkb:P17883	intact:EBI-1851|uniprotkb:Q06047|uniprotkb:D6VZ33|ensemblfungi:YLR398C	intact:EBI-1861|uniprotkb:Q06585|ensemblfungi:YPR189W	psi-mi:ski2_yeast(display_long)|uniprotkb:SKI2(gene name)|psi-mi:SKI2(display_short)|uniprotkb:YLR398C(locus name)|uniprotkb:L8084.17(orf name)|uniprotkb:Superkiller protein 2(gene name synonym)	psi-mi:ski3_yeast(display_long)|uniprotkb:SKI3(gene name)|psi-mi:SKI3(display_short)|uniprotkb:P9677.7(orf name)|uniprotkb:YPR189W(locus name)	psi-mi:"MI:0808"(comigration in sds page)	Halbach et al. (2013)	pubmed:23953113|imex:IM-21726	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8817618|wwpdb:4BUJ|imex:IM-21726-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000004390|refseq:NP_013502.3|dip:DIP-5887N|mint:P35207|ensemblfungi:YLR398C(gene)|ensemblfungi:YLR398C_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0051607"(defense response to virus)|go:"GO:0055087"(Ski complex)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012961(DSH, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016438(RNA helicase, ATP-dependent, SK12/DOB1)|interpro:IPR025696|interpro:IPR027417|interpro:IPR040801|rcsb pdb:4A4K|rcsb pdb:4A4Z|rcsb pdb:4BUJ|rcsb pdb:5MC6|reactome:R-SCE-429958	sgd:S000006393|refseq:NP_015515.1|dip:DIP-6379N|mint:P17883|ensemblfungi:YPR189W(gene)|ensemblfungi:YPR189W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0051607"(defense response to virus)|go:"GO:0055087"(Ski complex)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039226|interpro:IPR040962|rcsb pdb:4BUJ|rcsb pdb:5MC6|reactome:R-SCE-429958	-	crc64:7CCD36CFC0DF8C32	crc64:18FFF78D7CA5A6E4	figure legend:Supp. Fig. 4B|comment:"Mutation of SKI3 (gln1361ala_arg1362asp_tyr1365asp) decreases binding of SKI8"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/22	2014/10/16	rogid:qXGrLWktU2dryGHkNINEmcsbmFI559292	rogid:wjMKcbtN38crXFX7hQgZ0Bz475Y559292	intact-crc:A3314F473F4F3653|rigid:nsj0l2HfxwwY3IPSrf26a7ZdObg	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P35207	uniprotkb:Q02793	intact:EBI-1851|uniprotkb:Q06047|uniprotkb:D6VZ33|ensemblfungi:YLR398C	intact:EBI-17260|uniprotkb:D6VTU2|ensemblfungi:YGL213C	psi-mi:ski2_yeast(display_long)|uniprotkb:SKI2(gene name)|psi-mi:SKI2(display_short)|uniprotkb:YLR398C(locus name)|uniprotkb:L8084.17(orf name)|uniprotkb:Superkiller protein 2(gene name synonym)	psi-mi:ski8_yeast(display_long)|uniprotkb:YGL213C(locus name)|uniprotkb:SKI8(gene name)|psi-mi:SKI8(display_short)|uniprotkb:REC103(gene name synonym)|uniprotkb:Superkiller protein 8(gene name synonym)	psi-mi:"MI:0808"(comigration in sds page)	Halbach et al. (2013)	pubmed:23953113|imex:IM-21726	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8817618|wwpdb:4BUJ|imex:IM-21726-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000004390|refseq:NP_013502.3|dip:DIP-5887N|mint:P35207|ensemblfungi:YLR398C(gene)|ensemblfungi:YLR398C_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0051607"(defense response to virus)|go:"GO:0055087"(Ski complex)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012961(DSH, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016438(RNA helicase, ATP-dependent, SK12/DOB1)|interpro:IPR025696|interpro:IPR027417|interpro:IPR040801|rcsb pdb:4A4K|rcsb pdb:4A4Z|rcsb pdb:4BUJ|rcsb pdb:5MC6|reactome:R-SCE-429958	refseq:NP_011302.1|sgd:S000003181|ensemblfungi:YGL213C(gene)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0034622"|go:"GO:0051607"(defense response to virus)|go:"GO:0055087"(Ski complex)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|rcsb pdb:1S4U|rcsb pdb:1SQ9|rcsb pdb:4BUJ|rcsb pdb:5MC6|reactome:R-SCE-429958|reactome:R-SCE-674695|reactome:R-SCE-75955|ensemblfungi:YGL213C_mRNA(transcript)|dip:DIP-1653N|mint:Q02793	-	crc64:7CCD36CFC0DF8C32	crc64:C5E7B9D2268F9727	figure legend:Supp. Fig. 4B|comment:"Mutation of SKI3 (gln1361ala_arg1362asp_tyr1365asp) decreases binding of SKI8"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/22	2014/10/16	rogid:qXGrLWktU2dryGHkNINEmcsbmFI559292	rogid:6K6FJYcctdlT1321Nv6pOnQPwq8559292	intact-crc:A3314F473F4F3653|rigid:nsj0l2HfxwwY3IPSrf26a7ZdObg	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q08491	uniprotkb:Q02793	intact:EBI-1389|ensemblfungi:YOR076C|uniprotkb:O00032|uniprotkb:D6W2D9	intact:EBI-17260|uniprotkb:D6VTU2|ensemblfungi:YGL213C	psi-mi:ski7_yeast(display_long)|uniprotkb:SKI7(gene name)|psi-mi:SKI7(display_short)|uniprotkb:YOR29-27(orf name)|uniprotkb:YOR076C(locus name)	psi-mi:ski8_yeast(display_long)|uniprotkb:YGL213C(locus name)|uniprotkb:SKI8(gene name)|psi-mi:SKI8(display_short)|uniprotkb:REC103(gene name synonym)|uniprotkb:Superkiller protein 8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Halbach et al. (2013)	pubmed:23953113|imex:IM-21726	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8817878|imex:IM-21726-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YOR076C(gene)|ensemblfungi:YOR076C_mRNA(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0070651"(nonfunctional rRNA decay)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR027417|rcsb pdb:4ZKD|rcsb pdb:4ZKE|rcsb pdb:5G06|rcsb pdb:5JEA|refseq:NP_014719.1|sgd:S000005602|dip:DIP-995N|mint:Q08491	refseq:NP_011302.1|sgd:S000003181|ensemblfungi:YGL213C(gene)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0034622"|go:"GO:0051607"(defense response to virus)|go:"GO:0055087"(Ski complex)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|rcsb pdb:1S4U|rcsb pdb:1SQ9|rcsb pdb:4BUJ|rcsb pdb:5MC6|reactome:R-SCE-429958|reactome:R-SCE-674695|reactome:R-SCE-75955|ensemblfungi:YGL213C_mRNA(transcript)|dip:DIP-1653N|mint:Q02793	-	crc64:D93B956D02050BFA	crc64:C5E7B9D2268F9727	figure legend:Supp. Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/22	2014/10/16	rogid:lSRCPXKyO8g/c9UBMPr/zgCwS84559292	rogid:6K6FJYcctdlT1321Nv6pOnQPwq8559292	intact-crc:0167B8A49C75D8E5|rigid:xW63BMx+mIPkgi3nlm7kXXhSF0s	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q08491	uniprotkb:P35207	intact:EBI-1389|ensemblfungi:YOR076C|uniprotkb:O00032|uniprotkb:D6W2D9	intact:EBI-1851|uniprotkb:Q06047|uniprotkb:D6VZ33|ensemblfungi:YLR398C	psi-mi:ski7_yeast(display_long)|uniprotkb:SKI7(gene name)|psi-mi:SKI7(display_short)|uniprotkb:YOR29-27(orf name)|uniprotkb:YOR076C(locus name)	psi-mi:ski2_yeast(display_long)|uniprotkb:SKI2(gene name)|psi-mi:SKI2(display_short)|uniprotkb:YLR398C(locus name)|uniprotkb:L8084.17(orf name)|uniprotkb:Superkiller protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Halbach et al. (2013)	pubmed:23953113|imex:IM-21726	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8817878|imex:IM-21726-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YOR076C(gene)|ensemblfungi:YOR076C_mRNA(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0070651"(nonfunctional rRNA decay)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR027417|rcsb pdb:4ZKD|rcsb pdb:4ZKE|rcsb pdb:5G06|rcsb pdb:5JEA|refseq:NP_014719.1|sgd:S000005602|dip:DIP-995N|mint:Q08491	sgd:S000004390|refseq:NP_013502.3|dip:DIP-5887N|mint:P35207|ensemblfungi:YLR398C(gene)|ensemblfungi:YLR398C_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0051607"(defense response to virus)|go:"GO:0055087"(Ski complex)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012961(DSH, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016438(RNA helicase, ATP-dependent, SK12/DOB1)|interpro:IPR025696|interpro:IPR027417|interpro:IPR040801|rcsb pdb:4A4K|rcsb pdb:4A4Z|rcsb pdb:4BUJ|rcsb pdb:5MC6|reactome:R-SCE-429958	-	crc64:D93B956D02050BFA	crc64:7CCD36CFC0DF8C32	figure legend:Supp. Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/22	2014/10/16	rogid:lSRCPXKyO8g/c9UBMPr/zgCwS84559292	rogid:qXGrLWktU2dryGHkNINEmcsbmFI559292	intact-crc:0167B8A49C75D8E5|rigid:xW63BMx+mIPkgi3nlm7kXXhSF0s	false	glutathione s tranferase tag:n-n	sufficient binding region:1-834,1086-1287	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q08491	uniprotkb:P17883	intact:EBI-1389|ensemblfungi:YOR076C|uniprotkb:O00032|uniprotkb:D6W2D9	intact:EBI-1861|uniprotkb:Q06585|ensemblfungi:YPR189W	psi-mi:ski7_yeast(display_long)|uniprotkb:SKI7(gene name)|psi-mi:SKI7(display_short)|uniprotkb:YOR29-27(orf name)|uniprotkb:YOR076C(locus name)	psi-mi:ski3_yeast(display_long)|uniprotkb:SKI3(gene name)|psi-mi:SKI3(display_short)|uniprotkb:P9677.7(orf name)|uniprotkb:YPR189W(locus name)	psi-mi:"MI:0096"(pull down)	Halbach et al. (2013)	pubmed:23953113|imex:IM-21726	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8817878|imex:IM-21726-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YOR076C(gene)|ensemblfungi:YOR076C_mRNA(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0070651"(nonfunctional rRNA decay)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR027417|rcsb pdb:4ZKD|rcsb pdb:4ZKE|rcsb pdb:5G06|rcsb pdb:5JEA|refseq:NP_014719.1|sgd:S000005602|dip:DIP-995N|mint:Q08491	sgd:S000006393|refseq:NP_015515.1|dip:DIP-6379N|mint:P17883|ensemblfungi:YPR189W(gene)|ensemblfungi:YPR189W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0051607"(defense response to virus)|go:"GO:0055087"(Ski complex)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039226|interpro:IPR040962|rcsb pdb:4BUJ|rcsb pdb:5MC6|reactome:R-SCE-429958	-	crc64:D93B956D02050BFA	crc64:18FFF78D7CA5A6E4	figure legend:Supp. Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/22	2014/10/16	rogid:lSRCPXKyO8g/c9UBMPr/zgCwS84559292	rogid:wjMKcbtN38crXFX7hQgZ0Bz475Y559292	intact-crc:0167B8A49C75D8E5|rigid:xW63BMx+mIPkgi3nlm7kXXhSF0s	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q08491	uniprotkb:Q02793	intact:EBI-1389|ensemblfungi:YOR076C|uniprotkb:O00032|uniprotkb:D6W2D9	intact:EBI-17260|uniprotkb:D6VTU2|ensemblfungi:YGL213C	psi-mi:ski7_yeast(display_long)|uniprotkb:SKI7(gene name)|psi-mi:SKI7(display_short)|uniprotkb:YOR29-27(orf name)|uniprotkb:YOR076C(locus name)	psi-mi:ski8_yeast(display_long)|uniprotkb:YGL213C(locus name)|uniprotkb:SKI8(gene name)|psi-mi:SKI8(display_short)|uniprotkb:REC103(gene name synonym)|uniprotkb:Superkiller protein 8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Halbach et al. (2013)	pubmed:23953113|imex:IM-21726	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8818405|imex:IM-21726-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YOR076C(gene)|ensemblfungi:YOR076C_mRNA(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0070651"(nonfunctional rRNA decay)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR027417|rcsb pdb:4ZKD|rcsb pdb:4ZKE|rcsb pdb:5G06|rcsb pdb:5JEA|refseq:NP_014719.1|sgd:S000005602|dip:DIP-995N|mint:Q08491	refseq:NP_011302.1|sgd:S000003181|ensemblfungi:YGL213C(gene)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0034622"|go:"GO:0051607"(defense response to virus)|go:"GO:0055087"(Ski complex)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|rcsb pdb:1S4U|rcsb pdb:1SQ9|rcsb pdb:4BUJ|rcsb pdb:5MC6|reactome:R-SCE-429958|reactome:R-SCE-674695|reactome:R-SCE-75955|ensemblfungi:YGL213C_mRNA(transcript)|dip:DIP-1653N|mint:Q02793	-	crc64:D93B956D02050BFA	crc64:C5E7B9D2268F9727	figure legend:Supp. Fig. 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/22	2014/10/16	rogid:lSRCPXKyO8g/c9UBMPr/zgCwS84559292	rogid:6K6FJYcctdlT1321Nv6pOnQPwq8559292	intact-crc:F41D6B0F1009FCAE|rigid:IdHiXZHQSlbLcFQ5bwzznMfNlKc	false	glutathione s tranferase tag:n-n|sufficient binding region:488-747	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q08491	uniprotkb:P35207	intact:EBI-1389|ensemblfungi:YOR076C|uniprotkb:O00032|uniprotkb:D6W2D9	intact:EBI-1851|uniprotkb:Q06047|uniprotkb:D6VZ33|ensemblfungi:YLR398C	psi-mi:ski7_yeast(display_long)|uniprotkb:SKI7(gene name)|psi-mi:SKI7(display_short)|uniprotkb:YOR29-27(orf name)|uniprotkb:YOR076C(locus name)	psi-mi:ski2_yeast(display_long)|uniprotkb:SKI2(gene name)|psi-mi:SKI2(display_short)|uniprotkb:YLR398C(locus name)|uniprotkb:L8084.17(orf name)|uniprotkb:Superkiller protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Halbach et al. (2013)	pubmed:23953113|imex:IM-21726	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8818405|imex:IM-21726-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YOR076C(gene)|ensemblfungi:YOR076C_mRNA(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0070651"(nonfunctional rRNA decay)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR027417|rcsb pdb:4ZKD|rcsb pdb:4ZKE|rcsb pdb:5G06|rcsb pdb:5JEA|refseq:NP_014719.1|sgd:S000005602|dip:DIP-995N|mint:Q08491	sgd:S000004390|refseq:NP_013502.3|dip:DIP-5887N|mint:P35207|ensemblfungi:YLR398C(gene)|ensemblfungi:YLR398C_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0051607"(defense response to virus)|go:"GO:0055087"(Ski complex)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012961(DSH, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016438(RNA helicase, ATP-dependent, SK12/DOB1)|interpro:IPR025696|interpro:IPR027417|interpro:IPR040801|rcsb pdb:4A4K|rcsb pdb:4A4Z|rcsb pdb:4BUJ|rcsb pdb:5MC6|reactome:R-SCE-429958	-	crc64:D93B956D02050BFA	crc64:7CCD36CFC0DF8C32	figure legend:Supp. Fig. 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/22	2014/10/16	rogid:lSRCPXKyO8g/c9UBMPr/zgCwS84559292	rogid:qXGrLWktU2dryGHkNINEmcsbmFI559292	intact-crc:F41D6B0F1009FCAE|rigid:IdHiXZHQSlbLcFQ5bwzznMfNlKc	false	glutathione s tranferase tag:n-n|sufficient binding region:488-747	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:15422"	uniprotkb:P35207	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-1851|uniprotkb:Q06047|uniprotkb:D6VZ33|ensemblfungi:YLR398C	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:ski2_yeast(display_long)|uniprotkb:SKI2(gene name)|psi-mi:SKI2(display_short)|uniprotkb:YLR398C(locus name)|uniprotkb:L8084.17(orf name)|uniprotkb:Superkiller protein 2(gene name synonym)	psi-mi:"MI:0880"(atpase assay)	Halbach et al. (2013)	pubmed:23953113|imex:IM-21726	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8817233|imex:IM-21726-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	sgd:S000004390|refseq:NP_013502.3|dip:DIP-5887N|mint:P35207|ensemblfungi:YLR398C(gene)|ensemblfungi:YLR398C_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0051607"(defense response to virus)|go:"GO:0055087"(Ski complex)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012961(DSH, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016438(RNA helicase, ATP-dependent, SK12/DOB1)|interpro:IPR025696|interpro:IPR027417|interpro:IPR040801|rcsb pdb:4A4K|rcsb pdb:4A4Z|rcsb pdb:4BUJ|rcsb pdb:5MC6|reactome:R-SCE-429958	go:"GO:0006200"(obsolete ATP catabolic process)|go:"GO:0051117"(ATPase binding)	-	crc64:7CCD36CFC0DF8C32	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:2.96(second -1)|km:1.62x10^-4(molar)	2013/10/22	2014/10/16	-	rogid:qXGrLWktU2dryGHkNINEmcsbmFI559292	intact-crc:A405B03B6234583F	false	-	sufficient binding region:1086-1287,1-834	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15422"	wwpdb:4BUJ	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-1371206|intenz:3.6.4.13|rhea:"RHEA:13065"	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:ski_yeast(display_short)|psi-mi:4BUJ(display_long)|intact:SKI complex(complex recommended name)|intact:"SKI2:SKI3:SKI8"(complex systematic name)|intact:Ski2p-Ski3p-Ski8p complex(complex synonym)	psi-mi:"MI:0880"(atpase assay)	Halbach et al. (2013)	pubmed:23953113|imex:IM-21726	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8817317|imex:IM-21726-6	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	intact:EBI-1371221(exp-evidence)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0055087"(Ski complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0003723"(RNA binding)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0006402"(mRNA catabolic process)|complex portal:CPX-1040(complex-primary)|evidence ontology:"ECO:0000353"	go:"GO:0051117"(ATPase binding)|go:"GO:0006200"(obsolete ATP catabolic process)	-	curated-complex:"Central component of the 3'-5' cytoplasmic mRNA degradation pathway which interacts with Ski7 (Q08491) to mediate degradation by the exosome. The Ski complex appears to thread RNAs directly to the exosome, coupling the helicase and the exoribonuclease through a continuous RNA channel."|complex-properties:Ski3 forms an array of 33 TPR motifs organized in N-terminal and C-terminal arms. The C-terminal arm of Ski3 and the two Ski8 subunits position the helicase core of Ski2 centrally within the complex, enhancing RNA binding. The Ski3 N-terminal arm and the Ski2 insertion domain allosterically modulate the ATPase and helicase activities of the complex.   MW = 370-380kDa|complex-assembly:Heterotetramer	figure legend:Fig. 1B, 5B, Supp. Fig. 5B|stimulant:"CHEBI:33697 RNA"|causality statement:"CHEBI:33697 increases activity of P35207"|comment:When in complex with Ski3 and Ski8, the ATPase rate of Ski2 decreased 5-fold, whereas the KM for ATP remained essentially unchanged. Removal of residues 1-487 of SKI2 resulted in a significant increase in the helicase and ATPase activities of the Ski complex.|comment:"Removal of the insertion domain (835-1083) of Ski2 or of the N-terminal arm of Ski3 derepresses/increases the ATPase activity of Ski2 when bound in the Ski complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:5.7x10^-1(second -1)|km:1.62x10^-4(molar)	2013/10/22	2016/06/28	-	-	intact-crc:76D1CDB959EF2656	false	-	mutation decreasing interaction rate:445-445	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)