#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q99IB8-PRO_0000045602 uniprotkb:Q15392 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 intact:EBI-5457558|uniprotkb:B7Z817|ensembl:ENSP00000360316|ensembl:ENSP00000416585|uniprotkb:D3DQ51|uniprotkb:Q9HBA8|intact:EBI-10964490 psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:dhc24_human(display_long)|uniprotkb:DHCR24(gene name)|psi-mi:DHCR24(display_short)|uniprotkb:KIAA0018(gene name synonym)|uniprotkb:24-dehydrocholesterol reductase(gene name synonym)|uniprotkb:Diminuto/dwarf1 homolog(gene name synonym)|uniprotkb:Seladin-1(gene name synonym)|uniprotkb:3-beta-hydroxysterol Delta-24-reductase(gene name synonym) psi-mi:"MI:0096"(pull down) Salloum et al. (2013) pubmed:23935497|imex:IM-26076 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8784130|imex:IM-26076-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) ensembl:ENSG00000116133(gene)|ensembl:ENST00000371269(transcript)|ensembl:ENST00000436604(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000246"("delta24(24-1) sterol reductase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009888"(tissue development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016628"(oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)|go:"GO:0019899"(enzyme binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0031639"(plasminogen activation)|go:"GO:0033489"(cholesterol biosynthetic process via desmosterol)|go:"GO:0033490"(cholesterol biosynthetic process via lathosterol)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0050614"(delta24-sterol reductase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061024"(membrane organization)|go:"GO:0071949"(FAD binding)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR006094(FAD linked oxidase, N-terminal)|interpro:IPR016166(FAD-binding, type 2)|interpro:IPR016169(CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2)|interpro:IPR036318|interpro:IPR040165|go:"GO:0005737"(cytoplasm)|mint:Q15392|reactome:R-HSA-6807047|reactome:R-HSA-6807062|refseq:NP_055577.1 - chain-seq-start:1977|chain-seq-end:2442 - figure legend:Fig. 1 and table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh-7.5)|taxid:9606(Human Huh-7.5 cells) - 2013/09/27 2017/09/02 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 rogid:kg8bxZHxFFTUmvP9UQMeVFRNWQM9606 intact-crc:5CC425142B882F2F|rigid:s5IhU8R21SmH3eo/stJB18nZNEY false flag tag:?-?|strep ii tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99IB8-PRO_0000045602 uniprotkb:Q9P035 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 intact:EBI-359013|intact:EBI-1049123|uniprotkb:A0PJA1|uniprotkb:Q280Z3|uniprotkb:Q6PD63|uniprotkb:Q8IUI5|uniprotkb:Q8NC86|uniprotkb:Q8NCB1|uniprotkb:Q96T12|uniprotkb:Q9NQA7|uniprotkb:B4DRF4|intact:EBI-28973764|ensembl:ENSP00000261875 psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:hacd3_human(display_long)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:PTPLAD1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:HACD3(gene name)|psi-mi:HACD3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:BIND1(gene name synonym) psi-mi:"MI:0096"(pull down) Salloum et al. (2013) pubmed:23935497|imex:IM-26076 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8784130|imex:IM-26076-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) ensembl:ENSP00000261875|ensembl:ENST00000442729|ensembl:ENSP00000392491|refseq:NP_057479.2|ensembl:ENSG00000074696(gene)|ensembl:ENST00000261875(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005925"(focal adhesion)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q9P035|reactome:R-HSA-75876 - chain-seq-start:1977|chain-seq-end:2442 - figure legend:Fig. 1 and table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh-7.5)|taxid:9606(Human Huh-7.5 cells) - 2013/09/27 2017/09/02 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 rogid:U31K6H8I2f5j7FRhfHiY0cG4smA9606 intact-crc:5CC425142B882F2F|rigid:s5IhU8R21SmH3eo/stJB18nZNEY false flag tag:?-?|strep ii tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99IB8-PRO_0000045602 uniprotkb:Q14318 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 intact:EBI-724839|uniprotkb:Q53GU3|uniprotkb:Q7Z349|uniprotkb:Q86YK6|ensembl:ENSP00000222308|ensembl:ENSP00000472302|uniprotkb:C8C9T5 psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:fkbp8_human(display_long)|uniprotkb:FK506-binding protein 8(gene name synonym)|uniprotkb:38 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBPR38(gene name synonym)|uniprotkb:FKBP8(gene name)|psi-mi:FKBP8(display_short)|uniprotkb:FKBP38(gene name synonym)|uniprotkb:Rotamase(gene name synonym) psi-mi:"MI:0096"(pull down) Salloum et al. (2013) pubmed:23935497|imex:IM-26076 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8784130|imex:IM-26076-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) refseq:NP_036313.3|refseq:NP_001295302.1|go:"GO:0001708"(cell fate specification)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0046872"(metal ion binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:Q14318|ensembl:ENSG00000105701(gene)|rcsb pdb:2AWG|rcsb pdb:2D9F|rcsb pdb:2F2D|rcsb pdb:2MF9|rcsb pdb:3EY6|rcsb pdb:5MGX|reactome:R-HSA-5689880|ensembl:ENST00000222308(transcript)|ensembl:ENST00000596558(transcript)|refseq:XP_011526165.1|dip:DIP-42200N - chain-seq-start:1977|chain-seq-end:2442 - figure legend:Fig. 1 and table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh-7.5)|taxid:9606(Human Huh-7.5 cells) - 2013/09/27 2017/09/02 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 rogid:CpZqwry5szPluwNMwWXshCIMUvY9606 intact-crc:5CC425142B882F2F|rigid:s5IhU8R21SmH3eo/stJB18nZNEY false flag tag:?-?|strep ii tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99IB8-PRO_0000045602 uniprotkb:P62937 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 intact:EBI-437708|uniprotkb:P05092|uniprotkb:Q3KQW3|uniprotkb:Q6IBU5|uniprotkb:Q96IX3|uniprotkb:Q9BRU4|uniprotkb:Q9BTY9|uniprotkb:Q9UC61|uniprotkb:Q567Q0|ensembl:ENSP00000419425|uniprotkb:A8K220 psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:ppia_human(display_long)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:PPIA(gene name)|psi-mi:PPIA(display_short)|uniprotkb:CYPA(gene name synonym)|uniprotkb:Rotamase A(gene name synonym) psi-mi:"MI:0096"(pull down) Salloum et al. (2013) pubmed:23935497|imex:IM-26076 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8784130|imex:IM-26076-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) refseq:NP_066953.1|interpro:IPR029000|mint:P62937|rcsb pdb:1AK4|rcsb pdb:1AWQ|rcsb pdb:1AWR|rcsb pdb:1AWS|rcsb pdb:1AWT|rcsb pdb:1AWU|rcsb pdb:1AWV|rcsb pdb:1BCK|rcsb pdb:1CWA|rcsb pdb:1CWB|rcsb pdb:1CWC|rcsb pdb:1CWF|rcsb pdb:1CWH|rcsb pdb:1CWI|rcsb pdb:1CWJ|rcsb pdb:1CWK|rcsb pdb:1CWL|rcsb pdb:1CWM|interpro:IPR024936|rcsb pdb:1CWO|rcsb pdb:1FGL|rcsb pdb:2N0T|rcsb pdb:2RMA|rcsb pdb:1M63|rcsb pdb:2RMB|rcsb pdb:2X25|rcsb pdb:2X2A|rcsb pdb:2X2C|rcsb pdb:2X2D|rcsb pdb:1M9C|rcsb pdb:1M9D|rcsb pdb:1M9E|rcsb pdb:2XGY|rcsb pdb:3CYH|rcsb pdb:3CYS|rcsb pdb:3K0M|rcsb pdb:3K0N|rcsb pdb:3K0O|rcsb pdb:3K0P|rcsb pdb:3K0Q|rcsb pdb:3K0R|rcsb pdb:3ODI|rcsb pdb:3ODL|rcsb pdb:1M9F|rcsb pdb:3RDD|rcsb pdb:1M9X|rcsb pdb:1M9Y|rcsb pdb:4CYH|rcsb pdb:4IPZ|rcsb pdb:4N1M|rcsb pdb:4N1N|rcsb pdb:1MF8|rcsb pdb:4N1O|rcsb pdb:4N1P|rcsb pdb:4N1Q|rcsb pdb:1MIK|rcsb pdb:1NMK|rcsb pdb:1OCA|rcsb pdb:1RMH|rcsb pdb:1VBS|rcsb pdb:1VBT|rcsb pdb:1W8L|rcsb pdb:1W8M|rcsb pdb:1W8V|rcsb pdb:1YND|rcsb pdb:1ZKF|rcsb pdb:2ALF|rcsb pdb:2CPL|rcsb pdb:2CYH|rcsb pdb:2MS4|rcsb pdb:2MZU|rcsb pdb:4N1R|rcsb pdb:4N1S|rcsb pdb:4YUG|rcsb pdb:4YUH|refseq:NP_001287910.1|reactome:R-HSA-210991|reactome:R-HSA-6798695|reactome:R-HSA-8950505|reactome:R-HSA-2025928|ensembl:ENSG00000196262(gene)|ensembl:ENST00000468812(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046790"(virion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|go:"GO:0005178"(integrin binding)|rcsb pdb:4YUI|rcsb pdb:4YUJ|rcsb pdb:4YUK|rcsb pdb:4YUL|rcsb pdb:4YUM|rcsb pdb:4YUN|rcsb pdb:4YUO|rcsb pdb:4YUP|rcsb pdb:5CYH|rcsb pdb:5F66|rcsb pdb:5FJB|rcsb pdb:5KUL|rcsb pdb:5KUN|rcsb pdb:5KUO|rcsb pdb:5KUQ|rcsb pdb:5KUR|rcsb pdb:5KUS|rcsb pdb:5KUU|rcsb pdb:5KUV|rcsb pdb:5KUW|rcsb pdb:5KUZ|rcsb pdb:5KV0|rcsb pdb:5KV1|rcsb pdb:5KV2|rcsb pdb:5KV3|rcsb pdb:5KV4|rcsb pdb:5KV5|rcsb pdb:5KV6|rcsb pdb:5KV7|rcsb pdb:5LUD|rcsb pdb:5NOQ|rcsb pdb:5NOR|rcsb pdb:5NOT|rcsb pdb:5NOU|rcsb pdb:5NOV|rcsb pdb:5NOW|rcsb pdb:5NOX|rcsb pdb:5NOY|rcsb pdb:5NOZ|rcsb pdb:5T9U|rcsb pdb:5T9W|rcsb pdb:5T9Z|rcsb pdb:5TA2|rcsb pdb:5TA4|rcsb pdb:5WC7|rcsb pdb:6BTA|rcsb pdb:6GJI|rcsb pdb:6GJJ|rcsb pdb:6GJL|rcsb pdb:6GJM|rcsb pdb:6GJN|rcsb pdb:6GJP|rcsb pdb:6GJR|rcsb pdb:6GJY|rcsb pdb:6GS6|rcsb pdb:6I42|rcsb pdb:6U5C|rcsb pdb:6U5D|rcsb pdb:6U5E|rcsb pdb:6U5G|rcsb pdb:6X3R|rcsb pdb:6X3Y|rcsb pdb:5NOS|rcsb pdb:6X4N|rcsb pdb:6X4O|rcsb pdb:6X4P|rcsb pdb:6X4Q|rcsb pdb:6Y9V|rcsb pdb:6Y9W|rcsb pdb:6Y9X|rcsb pdb:6Y9Y|rcsb pdb:6Y9Z|rcsb pdb:6ZDJ|rcsb pdb:7ABT|reactome:R-HSA-114608|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-173107|rcsb pdb:6X4M|reactome:R-HSA-175474|reactome:R-HSA-180689|dip:DIP-6080N - chain-seq-start:1977|chain-seq-end:2442 - figure legend:Fig. 1 and table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh-7.5)|taxid:9606(Human Huh-7.5 cells) - 2013/09/27 2017/09/02 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 rogid:dr4EVxcO+sqTPBqsQcydRn+rHoo9606 intact-crc:5CC425142B882F2F|rigid:s5IhU8R21SmH3eo/stJB18nZNEY false flag tag:?-?|strep ii tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99IB8-PRO_0000045602 uniprotkb:Q9P0L0 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:"MI:0096"(pull down) Salloum et al. (2013) pubmed:23935497|imex:IM-26076 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8784130|imex:IM-26076-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) - chain-seq-start:1977|chain-seq-end:2442 - figure legend:Fig. 1 and table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh-7.5)|taxid:9606(Human Huh-7.5 cells) - 2013/09/27 2017/09/02 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 intact-crc:5CC425142B882F2F|rigid:s5IhU8R21SmH3eo/stJB18nZNEY false flag tag:?-?|strep ii tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99IB8-PRO_0000045602 uniprotkb:Q15717 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 intact:EBI-374260|uniprotkb:Q9BTT1|ensembl:ENSP00000385269|ensembl:ENSP00000472197|intact:EBI-6190219|uniprotkb:B4DVB8|uniprotkb:Q53XN6 psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:elav1_human(display_long)|uniprotkb:ELAVL1(gene name)|psi-mi:ELAVL1(display_short)|uniprotkb:HUR(gene name synonym)|uniprotkb:Hu-antigen R(gene name synonym) psi-mi:"MI:0096"(pull down) Salloum et al. (2013) pubmed:23935497|imex:IM-26076 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8784130|imex:IM-26076-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) go:"GO:0006606"(protein import into nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035198"(miRNA binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|ensembl:ENSG00000066044(gene)|ensembl:ENST00000407627(transcript)|ensembl:ENST00000596459(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|refseq:NP_001410.2|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034996|interpro:IPR035979|mint:Q15717|rcsb pdb:3HI9|rcsb pdb:4ED5|rcsb pdb:4EGL|rcsb pdb:4FXV|rcsb pdb:5SZW|rcsb pdb:6G2K|rcsb pdb:6GC5|rcsb pdb:6GD1|rcsb pdb:6GD2|rcsb pdb:6GD3|reactome:R-HSA-450520|reactome:R-HSA-72163|dip:DIP-31291N - chain-seq-start:1977|chain-seq-end:2442 - figure legend:Fig. 1 and table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh-7.5)|taxid:9606(Human Huh-7.5 cells) - 2013/09/27 2017/09/02 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 rogid:PciL5KuvP+2aUUv9cv7gWScgbw89606 intact-crc:5CC425142B882F2F|rigid:s5IhU8R21SmH3eo/stJB18nZNEY false flag tag:?-?|strep ii tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99IB8-PRO_0000045602 uniprotkb:P48729 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 intact:EBI-1383726|uniprotkb:Q96HD2|uniprotkb:Q5U046|uniprotkb:Q5U047|uniprotkb:Q6FGA2|uniprotkb:Q4JJA0|uniprotkb:Q9UDK3|intact:EBI-11048253|uniprotkb:D3DQG0|uniprotkb:D3DQG1|uniprotkb:Q71TU5|ensembl:ENSP00000367074 psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:kc1a_human(display_long)|uniprotkb:CSNK1A1(gene name)|psi-mi:CSNK1A1(display_short)|uniprotkb:CK1(gene name synonym) psi-mi:"MI:0096"(pull down) Salloum et al. (2013) pubmed:23935497|imex:IM-26076 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8784130|imex:IM-26076-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) refseq:NP_001020276.1|refseq:NP_001883.4|refseq:NP_001258670.1|refseq:NP_001258671.1|dip:DIP-40367N|ensembl:ENSG00000113712(gene)|ensembl:ENST00000377843(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007030"(Golgi organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051301"(cell division)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904424"(regulation of GTP binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P48729|rcsb pdb:5FQD|rcsb pdb:6GZD|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5635838 - chain-seq-start:1977|chain-seq-end:2442 - figure legend:Fig. 1 and table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh-7.5)|taxid:9606(Human Huh-7.5 cells) - 2013/09/27 2017/09/02 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 rogid:2rG1/sMVnsRKUEWsLhLAyHvqPnY9606 intact-crc:5CC425142B882F2F|rigid:s5IhU8R21SmH3eo/stJB18nZNEY false flag tag:?-?|strep ii tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99IB8-PRO_0000045602 uniprotkb:P53621 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 intact:EBI-356273|intact:EBI-1188425|uniprotkb:Q5T201|uniprotkb:Q8IXZ9|intact:EBI-2559704|intact:EBI-11576606|ensembl:ENSP00000241704 psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:copa_human(display_long)|uniprotkb:COPA(gene name)|psi-mi:COPA(display_short)|uniprotkb:Alpha-coat protein(gene name synonym)|uniprotkb:HEP-COP(gene name synonym) psi-mi:"MI:0096"(pull down) Salloum et al. (2013) pubmed:23935497|imex:IM-26076 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8784130|imex:IM-26076-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) refseq:NP_001091868.1|refseq:NP_004362.2|ensembl:ENSG00000122218(gene)|ensembl:ENST00000241704(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005179"(hormone activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030426"(growth cone)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR010714(Coatomer, alpha subunit, C-terminal)|interpro:IPR011048(Cytochrome cd1-nitrite reductase-like, C-terminal haem d1)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016391(Coatomer, alpha subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|mint:P53621|rcsb pdb:6PBG|rcsb pdb:6TZT|rcsb pdb:6U3V|reactome:R-HSA-6807878|reactome:R-HSA-6811434 - chain-seq-start:1977|chain-seq-end:2442 - figure legend:Fig. 1 and table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh-7.5)|taxid:9606(Human Huh-7.5 cells) - 2013/09/27 2017/09/02 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 rogid:9uP/NS7FjPrGDna1wcNHQy9py6A9606 intact-crc:5CC425142B882F2F|rigid:s5IhU8R21SmH3eo/stJB18nZNEY false flag tag:?-?|strep ii tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99IB8-PRO_0000045602 uniprotkb:P42356 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 intact:EBI-723050|uniprotkb:Q7Z625|uniprotkb:Q9UPG2|ensembl:ENSP00000255882|intact:EBI-11053324 psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:pi4ka_human(display_long)|uniprotkb:PIK4CA(gene name synonym)|uniprotkb:PI4KA(gene name)|psi-mi:PI4KA(display_short)|uniprotkb:PIK4(gene name synonym)|uniprotkb:Phosphatidylinositol 4-Kinase III alpha(gene name synonym) psi-mi:"MI:0096"(pull down) Salloum et al. (2013) pubmed:23935497|imex:IM-26076 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8784130|imex:IM-26076-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) ensembl:ENSG00000241973(gene)|ensembl:ENST00000255882(transcript)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0046786"(viral replication complex formation and maintenance)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR042236|rcsb pdb:6BQ1|reactome:R-HSA-1483248|reactome:R-HSA-1660514|go:"GO:0016301"(kinase activity)|refseq:NP_477352.3 - chain-seq-start:1977|chain-seq-end:2442 - figure legend:Fig. 1 and table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh-7.5)|taxid:9606(Human Huh-7.5 cells) - 2013/09/27 2017/09/02 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 rogid:tm7wwZPJEvFMfK9xHMPLW9oYtzk9606 intact-crc:5CC425142B882F2F|rigid:s5IhU8R21SmH3eo/stJB18nZNEY false flag tag:?-?|strep ii tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99IB8-PRO_0000045602 uniprotkb:Q9NP72 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 intact:EBI-722247|uniprotkb:Q53FX8|uniprotkb:Q6FIH1|uniprotkb:B3KMC7|uniprotkb:D3DRW1|intact:EBI-2859793|uniprotkb:Q56UN9|uniprotkb:B7Z333|ensembl:ENSP00000349415|ensembl:ENSP00000507542 psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:rab18_human(display_long)|uniprotkb:RAB18(gene name)|psi-mi:RAB18(display_short) psi-mi:"MI:0096"(pull down) Salloum et al. (2013) pubmed:23935497|imex:IM-26076 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8784130|imex:IM-26076-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) refseq:NP_067075.1|refseq:NP_001243339.1|refseq:NP_001243340.1|refseq:NP_001243341.1|refseq:NP_001243344.1|dip:DIP-60514N|ensembl:ENSG00000099246(gene)|ensembl:ENST00000356940(transcript)|ensembl:ENST00000682082(transcript)|go:"GO:0001654"(eye development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0045202"(synapse)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR025662|interpro:IPR027417|mint:Q9NP72|rcsb pdb:1X3S|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-8873719|reactome:R-HSA-8876198 - chain-seq-start:1977|chain-seq-end:2442 - figure legend:Fig. 1 and table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh-7.5)|taxid:9606(Human Huh-7.5 cells) - 2013/09/27 2017/09/02 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 rogid:xw6DaP3FsJo34UZC/jqjJEWfSeg9606 intact-crc:5CC425142B882F2F|rigid:s5IhU8R21SmH3eo/stJB18nZNEY false flag tag:?-?|strep ii tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99IB8-PRO_0000045602 uniprotkb:Q9NP72 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 intact:EBI-722247|uniprotkb:Q53FX8|uniprotkb:Q6FIH1|uniprotkb:B3KMC7|uniprotkb:D3DRW1|intact:EBI-2859793|uniprotkb:Q56UN9|uniprotkb:B7Z333|ensembl:ENSP00000349415|ensembl:ENSP00000507542 psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:rab18_human(display_long)|uniprotkb:RAB18(gene name)|psi-mi:RAB18(display_short) psi-mi:"MI:0428"(imaging technique) Salloum et al. (2013) pubmed:23935497|imex:IM-26076 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1335"(HPIDb) intact:EBI-8784224|imex:IM-26076-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) refseq:NP_067075.1|refseq:NP_001243339.1|refseq:NP_001243340.1|refseq:NP_001243341.1|refseq:NP_001243344.1|dip:DIP-60514N|ensembl:ENSG00000099246(gene)|ensembl:ENST00000356940(transcript)|ensembl:ENST00000682082(transcript)|go:"GO:0001654"(eye development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0045202"(synapse)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR025662|interpro:IPR027417|mint:Q9NP72|rcsb pdb:1X3S|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-8873719|reactome:R-HSA-8876198 go:"GO:0005811"(lipid droplet) chain-seq-start:1977|chain-seq-end:2442 - figure legend:Fig. 6C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh-7.5)|taxid:9606(Human Huh-7.5 cells) - 2013/09/27 2017/09/02 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 rogid:xw6DaP3FsJo34UZC/jqjJEWfSeg9606 intact-crc:7165DA6C3B774995|rigid:P5VNlAnClhp2QHl1cjloej2p3KM false - green fluorescent protein tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q99IB8-PRO_0000045602 uniprotkb:Q9NP72 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 intact:EBI-722247|uniprotkb:Q53FX8|uniprotkb:Q6FIH1|uniprotkb:B3KMC7|uniprotkb:D3DRW1|intact:EBI-2859793|uniprotkb:Q56UN9|uniprotkb:B7Z333|ensembl:ENSP00000349415|ensembl:ENSP00000507542 psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:rab18_human(display_long)|uniprotkb:RAB18(gene name)|psi-mi:RAB18(display_short) psi-mi:"MI:0428"(imaging technique) Salloum et al. (2013) pubmed:23935497|imex:IM-26076 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1335"(HPIDb) intact:EBI-8784166|imex:IM-26076-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) refseq:NP_067075.1|refseq:NP_001243339.1|refseq:NP_001243340.1|refseq:NP_001243341.1|refseq:NP_001243344.1|dip:DIP-60514N|ensembl:ENSG00000099246(gene)|ensembl:ENST00000356940(transcript)|ensembl:ENST00000682082(transcript)|go:"GO:0001654"(eye development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0045202"(synapse)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR025662|interpro:IPR027417|mint:Q9NP72|rcsb pdb:1X3S|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-8873719|reactome:R-HSA-8876198 - chain-seq-start:1977|chain-seq-end:2442 - figure legend:Fig. 2A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh-7.5)|taxid:9606(Human Huh-7.5 cells) - 2013/09/27 2017/09/02 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 rogid:xw6DaP3FsJo34UZC/jqjJEWfSeg9606 intact-crc:D422011CDC0E2E1A|rigid:P5VNlAnClhp2QHl1cjloej2p3KM false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q99IB8-PRO_0000045602 uniprotkb:Q9NP72 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 intact:EBI-722247|uniprotkb:Q53FX8|uniprotkb:Q6FIH1|uniprotkb:B3KMC7|uniprotkb:D3DRW1|intact:EBI-2859793|uniprotkb:Q56UN9|uniprotkb:B7Z333|ensembl:ENSP00000349415|ensembl:ENSP00000507542 psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:rab18_human(display_long)|uniprotkb:RAB18(gene name)|psi-mi:RAB18(display_short) psi-mi:"MI:0096"(pull down) Salloum et al. (2013) pubmed:23935497|imex:IM-26076 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8784202|imex:IM-26076-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) refseq:NP_067075.1|refseq:NP_001243339.1|refseq:NP_001243340.1|refseq:NP_001243341.1|refseq:NP_001243344.1|dip:DIP-60514N|ensembl:ENSG00000099246(gene)|ensembl:ENST00000356940(transcript)|ensembl:ENST00000682082(transcript)|go:"GO:0001654"(eye development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0045202"(synapse)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR025662|interpro:IPR027417|mint:Q9NP72|rcsb pdb:1X3S|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-8873719|reactome:R-HSA-8876198 - chain-seq-start:1977|chain-seq-end:2442 - figure legend:Fig. 6A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/09/27 2017/09/02 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 rogid:xw6DaP3FsJo34UZC/jqjJEWfSeg9606 intact-crc:0ED08FD85BF3693A|rigid:P5VNlAnClhp2QHl1cjloej2p3KM false flag tag:?-?|strep ii tag:?-? green fluorescent protein tag:?-?|mutation decreasing interaction:22-22 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NP72 uniprotkb:Q99IB8-PRO_0000045602 intact:EBI-722247|uniprotkb:Q53FX8|uniprotkb:Q6FIH1|uniprotkb:B3KMC7|uniprotkb:D3DRW1|intact:EBI-2859793|uniprotkb:Q56UN9|uniprotkb:B7Z333|ensembl:ENSP00000349415|ensembl:ENSP00000507542 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 psi-mi:rab18_human(display_long)|uniprotkb:RAB18(gene name)|psi-mi:RAB18(display_short) psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:"MI:0040"(electron microscopy) Salloum et al. (2013) pubmed:23935497|imex:IM-26076 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1335"(HPIDb) intact:EBI-8789549|imex:IM-26076-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067075.1|refseq:NP_001243339.1|refseq:NP_001243340.1|refseq:NP_001243341.1|refseq:NP_001243344.1|dip:DIP-60514N|ensembl:ENSG00000099246(gene)|ensembl:ENST00000356940(transcript)|ensembl:ENST00000682082(transcript)|go:"GO:0001654"(eye development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0045202"(synapse)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR025662|interpro:IPR027417|mint:Q9NP72|rcsb pdb:1X3S|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-8873719|reactome:R-HSA-8876198 intact:EBI-6674379(chain-parent) go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0005811"(lipid droplet) - chain-seq-start:1977|chain-seq-end:2442 figure legend:Fig. 2C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh-7.5)|taxid:9606(Human Huh-7.5 cells) - 2013/09/27 2014/10/16 rogid:xw6DaP3FsJo34UZC/jqjJEWfSeg9606 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 intact-crc:E948F252BB35E5BB|rigid:P5VNlAnClhp2QHl1cjloej2p3KM false green fluorescent protein tag:?-? - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)