#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y3I1	uniprotkb:O60260	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102919|imex:IM-22049-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	-	-	-	figure legend:Supp 1A|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/12/24	2014/10/16	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	intact-crc:0356D950516CACAE|rigid:A2NEUFUcla8WDJI0siObVCXo4ls	false	-	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O60260	uniprotkb:Q9Y3I1	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102150|imex:IM-22049-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	go:"GO:0005829"(cytosol)|go:"GO:0005739"(mitochondrion)	-	-	figure legend:1C/H.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/12/24	2014/10/16	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	intact-crc:DBBDAB159FCDD3BA|rigid:A2NEUFUcla8WDJI0siObVCXo4ls	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BXM7	uniprotkb:Q9Y3I1	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9103064|imex:IM-22049-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	-	-	-	figure legend:Supp 4A|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2013/12/24	2014/10/16	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	intact-crc:2613605F468BF1E9|rigid:81fxhQt6//eRi3Ewovv0ppU1iv0	false	myc tag:?-?	t7 tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y3I1	uniprotkb:O60260	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102100|imex:IM-22049-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	-	-	-	figure legend:1B/G|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2013/12/24	2014/10/16	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	intact-crc:221EB2E7D9A53E79|rigid:A2NEUFUcla8WDJI0siObVCXo4ls	false	ha tag:?-?|mutation disrupting interaction:22-22	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BXM7	uniprotkb:Q9Y3I1-1	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	intact:EBI-9102965|ensembl:ENSP00000266087	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:q9y3i1-1(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102660|imex:IM-22049-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N	intact:EBI-1161222(isoform-parent)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)	-	-	-	figure legend:4B, 4C|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2013/12/24	2014/10/16	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	intact-crc:6B9E0943D28FC75C|rigid:81fxhQt6//eRi3Ewovv0ppU1iv0	false	myc tag:?-?	necessary binding region:1-128|flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y3I1-1	uniprotkb:O60260	intact:EBI-9102965|ensembl:ENSP00000266087	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	psi-mi:q9y3i1-1(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102181|imex:IM-22049-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1161222(isoform-parent)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	-	-	-	figure legend:1D|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2013/12/24	2014/10/16	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	intact-crc:521FF1B3DF94E8AA|rigid:A2NEUFUcla8WDJI0siObVCXo4ls	false	t7 tag:n-n|necessary binding region:1-88	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60260	uniprotkb:Q9Y3I1-1	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	intact:EBI-9102965|ensembl:ENSP00000266087	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:q9y3i1-1(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102955|imex:IM-22049-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	intact:EBI-1161222(isoform-parent)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)	intact:EBI-9102985(see-also)	-	-	figure legend:Supp  1B|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2013/12/24	2014/10/16	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	intact-crc:51DA4E361BEDD30A|rigid:A2NEUFUcla8WDJI0siObVCXo4ls	false	flag tag:?-?	t7 tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60260	uniprotkb:Q9Y3I1	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9106034|imex:IM-22049-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	go:"GO:0005739"(mitochondrion)	-	-	figure legend:2B.|agonist:CCCP- carbonyl cyanide 3-chlorophenylhydrazone, an uncoupler of oxidative phosphorylation/electron transport in mitochondria.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2013/12/24	2014/10/16	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	intact-crc:047AC04A4EB27760|rigid:A2NEUFUcla8WDJI0siObVCXo4ls	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BXM7	uniprotkb:Q9Y3I1	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102745|imex:IM-22049-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	-	-	-	figure legend:4D|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/24	2014/10/16	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	intact-crc:CEDBF18B8E68F588|rigid:81fxhQt6//eRi3Ewovv0ppU1iv0	false	myc tag:?-?	glutathione s tranferase tag:n-n|necessary binding region:1-128	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y3I1	uniprotkb:Q9BXM7	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9103074|imex:IM-22049-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N	-	-	-	figure legend:Supp 4B|comment:This interaction was unaffected by Fbxo7 pathogenic mutations - T22M,  R378G and R498X.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2013/12/24	2014/10/16	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	intact-crc:A36776469CAE72FB|rigid:81fxhQt6//eRi3Ewovv0ppU1iv0	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O60260	uniprotkb:Q9Y3I1	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9103030|imex:IM-22049-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	-	-	-	figure legend:Supp 1C/D|comment:Both the R378G and R498X mutations caused no significant change in Parkin binding.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2013/12/24	2014/10/16	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	intact-crc:69B9C3123A10C94F|rigid:A2NEUFUcla8WDJI0siObVCXo4ls	false	flag tag:?-?	ha tag:?-?|mutation disrupting interaction:22-22	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BXM7	uniprotkb:Q9Y3I1	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102650|imex:IM-22049-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	-	-	-	figure legend:4A|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2013/12/24	2014/10/16	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	intact-crc:C498CEABD18C7689|rigid:81fxhQt6//eRi3Ewovv0ppU1iv0	false	myc tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y3I1-2	uniprotkb:Q9BXM7	intact:EBI-9103020|ensembl:ENSP00000388547	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	psi-mi:q9y3i1-2(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9103114|imex:IM-22049-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100225(gene)|ensembl:ENST00000452138(transcript)|intact:EBI-1161222(isoform-parent)	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N	-	-	-	figure legend:Supp 4C|comment:PINK1 retained partial binding to Fbxo7 isoform 2.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2013/12/24	2014/10/16	rogid:McInYbvzYFKfgk+bkdGY0aAIEac9606	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	intact-crc:78A8356CB08141CE|rigid:1XY32igQHcVlNOvCsfKq529g1RU	false	flag tag:n-n	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BXM7	uniprotkb:Q9Y3I1-1	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	intact:EBI-9102965|ensembl:ENSP00000266087	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:q9y3i1-1(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9103094|imex:IM-22049-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N	intact:EBI-1161222(isoform-parent)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)	-	-	-	figure legend:Supp 4C|comment:PINK1 retained partial binding to Fbxo7 isoform 2.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2013/12/24	2014/10/16	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	intact-crc:785BC653B3AE085E|rigid:81fxhQt6//eRi3Ewovv0ppU1iv0	false	myc tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O60260	uniprotkb:Q9Y3I1	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102234|imex:IM-22049-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	-	-	-	figure legend:1E|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2013/12/24	2014/10/16	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	intact-crc:5E3B6FE956015B39|rigid:A2NEUFUcla8WDJI0siObVCXo4ls	false	flag tag:?-?	sufficient binding region:1-398|t7 tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O60260	uniprotkb:Q9Y3I1	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102847|imex:IM-22049-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	-	-	-	figure legend:4F-2|comment:Fbxo7, Parkin and PINK1 probably interact in a noncompetitive, nonsynergistic manner.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/24	2014/10/16	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	intact-crc:36A678322E88A70E|rigid:n+ua+OBu5KSL3Xzw++2j1bB8ZrA	false	glutathione s tranferase tag:n-n	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60260	uniprotkb:Q9BXM7	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102847|imex:IM-22049-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N	-	-	-	figure legend:4F-2|comment:Fbxo7, Parkin and PINK1 probably interact in a noncompetitive, nonsynergistic manner.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/24	2014/10/16	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	intact-crc:36A678322E88A70E|rigid:n+ua+OBu5KSL3Xzw++2j1bB8ZrA	false	glutathione s tranferase tag:n-n	t7 tag:?-?|sufficient binding region:104-581	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BXM7	uniprotkb:O60260	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102797|imex:IM-22049-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	-	-	-	figure legend:4F|comment:Fbxo7, Parkin and PINK1 probably interact in a noncompetitive, nonsynergistic manner.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/24	2014/10/16	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	intact-crc:2C64AAEAA0B90524|rigid:n+ua+OBu5KSL3Xzw++2j1bB8ZrA	false	sufficient binding region:104-581|glutathione s tranferase tag:n-n	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BXM7	uniprotkb:Q9Y3I1	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102797|imex:IM-22049-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	-	-	-	figure legend:4F|comment:Fbxo7, Parkin and PINK1 probably interact in a noncompetitive, nonsynergistic manner.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/24	2014/10/16	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	intact-crc:2C64AAEAA0B90524|rigid:n+ua+OBu5KSL3Xzw++2j1bB8ZrA	false	sufficient binding region:104-581|glutathione s tranferase tag:n-n	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60260	uniprotkb:Q9Y3I1	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102262|imex:IM-22049-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	-	-	-	figure legend:1F, 4E|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/24	2014/10/16	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	intact-crc:6A3A914EDEFB9EA3|rigid:A2NEUFUcla8WDJI0siObVCXo4ls	false	flag tag:?-?	sufficient binding region:1-88|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BXM7	uniprotkb:Q9Y3I1	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102766|imex:IM-22049-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	-	-	-	figure legend:4Ei|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/24	2014/10/16	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	intact-crc:E2F58949D338DEA7|rigid:81fxhQt6//eRi3Ewovv0ppU1iv0	false	sufficient binding region:104-581|myc tag:?-?	glutathione s tranferase tag:n-n|sufficient binding region:1-398	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y3I1	uniprotkb:O60260	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102869|imex:IM-22049-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	-	-	-	figure legend:4F-2i|comment:Fbxo7, Parkin and PINK1 probably interact in a noncompetitive, nonsynergistic manner.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/24	2014/10/16	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	intact-crc:1D388B6157D36053|rigid:A2NEUFUcla8WDJI0siObVCXo4ls	false	ha tag:?-?	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60260	uniprotkb:Q9BXM7	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102883|imex:IM-22049-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N	-	-	-	figure legend:4F-2ii|comment:Fbxo7, Parkin and PINK1 probably interact in a noncompetitive, nonsynergistic manner.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/24	2014/10/16	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	intact-crc:46CFB026713478B8|rigid:ys26Qm474XDafyyZe2XykP1phtY	false	glutathione s tranferase tag:n-n	sufficient binding region:104-581|t7 tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BXM7	uniprotkb:Q9Y3I1	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102832|imex:IM-22049-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	-	-	-	figure legend:4Fii|comment:Fbxo7, Parkin and PINK1 probably interact in a noncompetitive, nonsynergistic manner.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/24	2014/10/16	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	intact-crc:E3D8EC1FE7710249|rigid:81fxhQt6//eRi3Ewovv0ppU1iv0	false	sufficient binding region:104-581|glutathione s tranferase tag:n-n	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y3I1	uniprotkb:Q9BXM7	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102778|imex:IM-22049-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N	-	-	-	figure legend:4Eii|comment:The first 103 amino acids of PINK1 are not necessary for this interaction.  Neither Parkin nor PINK1 had any significant effect on the interaction of Fbxo7 with the other protein.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/24	2014/10/16	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	intact-crc:E268270035CF74B4|rigid:n+ua+OBu5KSL3Xzw++2j1bB8ZrA	false	glutathione s tranferase tag:n-n|sufficient binding region:1-398	myc tag:?-?|sufficient binding region:104-581	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y3I1	uniprotkb:O60260	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Burchell et al. (2013)	pubmed:23933751|imex:IM-22049	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9102778|imex:IM-22049-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	-	-	-	figure legend:4Eii|comment:The first 103 amino acids of PINK1 are not necessary for this interaction.  Neither Parkin nor PINK1 had any significant effect on the interaction of Fbxo7 with the other protein.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/24	2014/10/16	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	intact-crc:E268270035CF74B4|rigid:n+ua+OBu5KSL3Xzw++2j1bB8ZrA	false	glutathione s tranferase tag:n-n|sufficient binding region:1-398	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)