#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P37840	uniprotkb:P37840	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0943"(detection by mass spectrometry)	Coelho-Cerqueira et al. (2013)	imex:IM-21008|pubmed:23927048	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6914918|imex:IM-21008-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:f2c|comment:"Mass spectrometry (MALDI-TOF/TOF) was used to confirm the  oligomeric state of cross-linked α-syn. A molecular mass of 14,458 Da was obtained  from the MALDI-TOF/TOF spectrum of non-cross-linked α-syn purified using the  heating protocol (Figure 2C), and no differences were observed in comparison with α-  syn purified using the acidification protocol (data not shown). After cross-linking, both  heat- and acid-purified α-syn exhibited a minor population of dimers and trimers with the  predominant monomer. For the α-syn purified using the heating protocol, a very small  population of tetramers (64,269 Da) was also observed. Together, the analysis of crosslinked  α-syn by both SDS-PAGE and mass spectroscopy indicated that the protein is  mostly monomeric with a small population of oligomers, notably dimers."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/04	2019/02/08	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	intact-crc:E69C780C86AA55A4|rigid:E5NmyFtphazMnJg1dBFmql6CQT4	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37840	uniprotkb:P37840	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0943"(detection by mass spectrometry)	Coelho-Cerqueira et al. (2013)	imex:IM-21008|pubmed:23927048	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6914913|imex:IM-21008-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:f2c|comment:"Mass spectrometry (MALDI-TOF/TOF) was used to confirm the  oligomeric state of cross-linked α-syn. A molecular mass of 14,458 Da was obtained  from the MALDI-TOF/TOF spectrum of non-cross-linked α-syn purified using the  heating protocol (Figure 2C), and no differences were observed in comparison with α-  syn purified using the acidification protocol (data not shown). After cross-linking, both  heat- and acid-purified α-syn exhibited a minor population of dimers and trimers with the  predominant monomer. For the α-syn purified using the heating protocol, a very small  population of tetramers (64,269 Da) was also observed. Together, the analysis of crosslinked  α-syn by both SDS-PAGE and mass spectroscopy indicated that the protein is  mostly monomeric with a small population of oligomers, notably dimers."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/04	2019/02/08	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	intact-crc:4279C6827CA45252|rigid:i1lTW0BO6MRY8q+v4ogFoecEy94	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37840	uniprotkb:P37840	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Coelho-Cerqueira et al. (2013)	imex:IM-21008|pubmed:23927048	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6914889|imex:IM-21008-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:f2a f2b f3g f4a|comment:"To determine the oligomeric state of the recombinant α-syn  purified with either the heating or the acidification protocol, the protein was cross-linked  with GHD and then analyzed by SDS-PAGE (Figure 2). After cross-linking, a smallpopulation of α-syn was found as dimers (3-5% of total α-syn) with an apparent  molecular mass of ~34 kDa, as determined using the Totallab software (Figures 2A and  2B). These species were also revealed by western blot using the monoclonal antibody  anti-human α-syn 14H2L1. We also observed a very small population of α-syn running at  ~60 kDa. Because α-syn monomers and dimers exhibit respective molecular masses of 18  and 34 kDa according to SDS-PAGE, this 60 kDa protein may be either a tetrameric or  trimeric form of α-syn."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/04	2019/02/08	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	intact-crc:0E432395B8B489D8|rigid:i1lTW0BO6MRY8q+v4ogFoecEy94	false	-	-	2	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P37840	uniprotkb:P37840	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Coelho-Cerqueira et al. (2013)	imex:IM-21008|pubmed:23927048	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6914902|imex:IM-21008-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:f3d f3e f3f|comment:Collectively, these data provide convincing evidence that α-syn dimers are highly  dynamic and exist in equilibrium with the monomeric species|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/04	2019/02/08	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	intact-crc:279B2EFA1E958FAB|rigid:i1lTW0BO6MRY8q+v4ogFoecEy94	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37840	uniprotkb:P37840	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0016"(circular dichroism)	Coelho-Cerqueira et al. (2013)	imex:IM-21008|pubmed:23927048	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6914876|imex:IM-21008-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	-	-	figure legend:f1b f1c f4b|comment:"Both heat- and acid-purified α-syn displayed a CD spectrum with a negative band  at 200 nm that is typical of disordered structures, although a slight band at approximately  220 nm was verified for the α-syn obtained using the heating protocol (Figure 1B).  Additionally, the α-syn purified by both the acidification and heating methods displayed  similar fibrillogenic properties; typical sigmoidal curves for the kinetics of fibrillization  were observed, with an initial lag phase, associated with the nucleation process, followed  by an exponential growth phase (Figure 1C)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/04	2019/02/08	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	intact-crc:39FE0FB70ECE3E52|rigid:E5NmyFtphazMnJg1dBFmql6CQT4	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)