#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P54198	uniprotkb:Q8BVE8	intact:EBI-372342|uniprotkb:Q05BU9|uniprotkb:Q8IXN2|ensembl:ENSP00000263208	intact:EBI-8847927|uniprotkb:B3VCH6|uniprotkb:Q6ZPY1|uniprotkb:Q7TSF5|uniprotkb:Q811F0|ensembl:ENSMUSP00000058940	psi-mi:hira_human(display_long)|uniprotkb:HIRA(gene name)|psi-mi:HIRA(display_short)|uniprotkb:TUP1-like enhancer of split protein 1(gene name synonym)|uniprotkb:DGCR1(gene name synonym)|uniprotkb:HIR(gene name synonym)|uniprotkb:TUPLE1(gene name synonym)	psi-mi:nsd2_mouse(display_long)|uniprotkb:Nsd2(gene name)|psi-mi:Nsd2(display_short)|uniprotkb:Kiaa1090(gene name synonym)|uniprotkb:Multiple myeloma SET domain-containing protein(gene name synonym)|uniprotkb:Nuclear SET domain-containing protein 2(gene name synonym)|uniprotkb:Whsc1(gene name synonym)|uniprotkb:Wolf-Hirschhorn syndrome candidate 1 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sarai et al. (2013)	pubmed:23921552|imex:IM-21698	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8847925|imex:IM-21698-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003316.3|dip:DIP-29240N|ensembl:ENSG00000100084(gene)|ensembl:ENST00000263208(transcript)|go:"GO:0000417"(HIR complex)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0016605"(PML body)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR011494(TUP1-like enhancer of split)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031120|interpro:IPR036322|mint:P54198|rcsb pdb:2I32|rcsb pdb:5YJE|reactome:R-HSA-2559584	refseq:XP_017176079.1|refseq:NP_001074571.2|refseq:NP_780440.2|refseq:XP_006503721.1|refseq:XP_006503722.1|refseq:XP_006503723.1|dip:DIP-60452N|ensembl:ENSMUSG00000057406(gene)|ensembl:ENSMUST00000058096(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0003290"(atrial septum secundum morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010452"(histone H3-K36 methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0034770"(histone H4-K20 methylation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046975"("histone methyltransferase activity (H3-K36 specific)")|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0060348"(bone development)|go:"GO:0070201"(regulation of establishment of protein localization)|interpro:IPR000313(PWWP)|interpro:IPR001214(SET)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR006560(AWS)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036910|interpro:IPR041306|mint:Q8BVE8|reactome:R-MMU-3214841|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|go:"GO:2001032"(regulation of double-strand break repair via nonhomologous end joining)	-	-	-	figure legend:f5c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/11/11	2014/10/16	rogid:en6l6z4CNWhF4Wlj5ou4DDTfETg9606	rogid:cL84Mkvlu++GafQarYkA2Yf8lvc10090	intact-crc:6060CE91B3955EEC|rigid:nA7IWLuNSnt0yB48c2i5KcA1OyQ	false	yellow fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8BVE8	uniprotkb:Q61666	intact:EBI-8847927|uniprotkb:B3VCH6|uniprotkb:Q6ZPY1|uniprotkb:Q7TSF5|uniprotkb:Q811F0|ensembl:ENSMUSP00000058940	intact:EBI-2657552|uniprotkb:O08845|uniprotkb:Q3TFY0|uniprotkb:Q3UX35|uniprotkb:Q62365|uniprotkb:Q7TMW4|ensembl:ENSMUSP00000004222	psi-mi:nsd2_mouse(display_long)|uniprotkb:Nsd2(gene name)|psi-mi:Nsd2(display_short)|uniprotkb:Kiaa1090(gene name synonym)|uniprotkb:Multiple myeloma SET domain-containing protein(gene name synonym)|uniprotkb:Nuclear SET domain-containing protein 2(gene name synonym)|uniprotkb:Whsc1(gene name synonym)|uniprotkb:Wolf-Hirschhorn syndrome candidate 1 protein homolog(gene name synonym)	psi-mi:hira_mouse(display_long)|uniprotkb:Hira(gene name)|psi-mi:Hira(display_short)|uniprotkb:Tuple1(gene name synonym)|uniprotkb:TUP1-like enhancer of split protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sarai et al. (2013)	pubmed:23921552|imex:IM-21698	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8847988|imex:IM-21698-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017176079.1|refseq:NP_001074571.2|refseq:NP_780440.2|refseq:XP_006503721.1|refseq:XP_006503722.1|refseq:XP_006503723.1|dip:DIP-60452N|ensembl:ENSMUSG00000057406(gene)|ensembl:ENSMUST00000058096(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0003290"(atrial septum secundum morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010452"(histone H3-K36 methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0034770"(histone H4-K20 methylation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046975"("histone methyltransferase activity (H3-K36 specific)")|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0060348"(bone development)|go:"GO:0070201"(regulation of establishment of protein localization)|interpro:IPR000313(PWWP)|interpro:IPR001214(SET)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR006560(AWS)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036910|interpro:IPR041306|mint:Q8BVE8|reactome:R-MMU-3214841|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|go:"GO:2001032"(regulation of double-strand break repair via nonhomologous end joining)	refseq:NP_034565.2|ensembl:ENSMUSG00000022702(gene)|ensembl:ENSMUST00000004222(transcript)|go:"GO:0000417"(HIR complex)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007369"(gastrulation)|go:"GO:0016605"(PML body)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR011494(TUP1-like enhancer of split)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031120|interpro:IPR036322|mint:Q61666|reactome:R-MMU-2559584	-	-	-	figure legend:f5d f5e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/11/11	2014/10/16	rogid:cL84Mkvlu++GafQarYkA2Yf8lvc10090	rogid:EhPH7DlphMVQhvIhJUtXRA1m+Fg10090	intact-crc:E14C616730B29C14|rigid:5p/PBJAOchEB7+u6nihThPVVkrs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8BVE8	uniprotkb:Q9ESU6	intact:EBI-8847927|uniprotkb:B3VCH6|uniprotkb:Q6ZPY1|uniprotkb:Q7TSF5|uniprotkb:Q811F0|ensembl:ENSMUSP00000058940	intact:EBI-6260864|ensembl:ENSMUSP00000113070|uniprotkb:Q8VHF7|uniprotkb:Q8VHF8|uniprotkb:B0V2V7	psi-mi:nsd2_mouse(display_long)|uniprotkb:Nsd2(gene name)|psi-mi:Nsd2(display_short)|uniprotkb:Kiaa1090(gene name synonym)|uniprotkb:Multiple myeloma SET domain-containing protein(gene name synonym)|uniprotkb:Nuclear SET domain-containing protein 2(gene name synonym)|uniprotkb:Whsc1(gene name synonym)|uniprotkb:Wolf-Hirschhorn syndrome candidate 1 protein homolog(gene name synonym)	psi-mi:brd4_mouse(display_long)|uniprotkb:Mcap(gene name synonym)|uniprotkb:Mitotic chromosome-associated protein(gene name synonym)|uniprotkb:Brd4(gene name)|psi-mi:Brd4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sarai et al. (2013)	pubmed:23921552|imex:IM-21698	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8847988|imex:IM-21698-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017176079.1|refseq:NP_001074571.2|refseq:NP_780440.2|refseq:XP_006503721.1|refseq:XP_006503722.1|refseq:XP_006503723.1|dip:DIP-60452N|ensembl:ENSMUSG00000057406(gene)|ensembl:ENSMUST00000058096(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0003290"(atrial septum secundum morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010452"(histone H3-K36 methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0034770"(histone H4-K20 methylation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046975"("histone methyltransferase activity (H3-K36 specific)")|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0060348"(bone development)|go:"GO:0070201"(regulation of establishment of protein localization)|interpro:IPR000313(PWWP)|interpro:IPR001214(SET)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR006560(AWS)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036910|interpro:IPR041306|mint:Q8BVE8|reactome:R-MMU-3214841|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473|go:"GO:2001032"(regulation of double-strand break repair via nonhomologous end joining)	ensembl:ENSMUSG00000024002(gene)|ensembl:ENSMUST00000121285(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043983"(histone H4-K12 acetylation)|go:"GO:0044154"(histone H3-K14 acetylation)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:Q9ESU6|rcsb pdb:2DWW|rcsb pdb:2JNS|rcsb pdb:3JVJ|rcsb pdb:3JVK|rcsb pdb:3JVL|rcsb pdb:3JVM|rcsb pdb:3MUK|rcsb pdb:3MUL|refseq:XP_006524751.1|refseq:XP_006524752.1|refseq:NP_065254.3|refseq:NP_932762.2|dip:DIP-42181N	-	-	-	figure legend:f5d f5e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/11/11	2014/10/16	rogid:cL84Mkvlu++GafQarYkA2Yf8lvc10090	rogid:aD51lXIT5Ap1qkTwaWqQfkDcHA810090	intact-crc:E14C616730B29C14|rigid:5p/PBJAOchEB7+u6nihThPVVkrs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)