#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04578	uniprotkb:P04608	intact:EBI-6163496|uniprotkb:O09779	intact:EBI-6164389|uniprotkb:O09778	psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym)	psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cardaci et al. (2013)	pubmed:23916815|imex:IM-20959	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6899558|imex:IM-20959-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC	go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF	-	-	crc64:4DDC56D979769115	figure legend:f3|comment:"This assay showed that Tat binding to both V1- and V2-gp120 was as low as ~30%, compared to wild-type gp120. Remarkably, V1/V2-gp120 was almost completely unable to interact with Tat (Figure 3B)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/22	2014/10/16	rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706	rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706	intact-crc:79182C5022F5833A|rigid:qMkM49oz3yjLGMFPbavHY8odtKA	false	polyprotein fragment:33-511|necessary binding region:159-194,133-155|mutation increasing interaction:170-170,171-171	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04608	uniprotkb:P04578	intact:EBI-6164389|uniprotkb:O09778	intact:EBI-6163496|uniprotkb:O09779	psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym)	psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cardaci et al. (2013)	pubmed:23916815|imex:IM-20959	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6898773|imex:IM-20959-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF	refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC	-	crc64:4DDC56D979769115	-	figure legend:f3|comment:"This assay showed that Tat binding to both V1- and V2-gp120 was as low as ~30%, compared to wild-type gp120. Remarkably, V1/V2-gp120 was almost completely unable to interact with Tat (Figure 3B)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/22	2014/10/16	rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706	rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706	intact-crc:ED20DFCD61E46066|rigid:qMkM49oz3yjLGMFPbavHY8odtKA	false	glutathione s tranferase tag:?-?	necessary binding region:159-194,133-155|mutation increasing interaction:170-170,171-171,168-168|polyprotein fragment:33-511	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04578	uniprotkb:P04608	intact:EBI-6163496|uniprotkb:O09779	intact:EBI-6164389|uniprotkb:O09778	psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym)	psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cardaci et al. (2013)	pubmed:23916815|imex:IM-20959	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6899484|imex:IM-20959-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC	go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF	-	-	crc64:4DDC56D979769115	figure legend:f3|comment:"This assay showed that Tat binding to both V1- and V2-gp120 was as low as ~30%, compared to wild-type gp120. Remarkably, V1/V2-gp120 was almost completely unable to interact with Tat (Figure 3B)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/22	2014/10/16	rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706	rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706	intact-crc:F9966325F7508A20|rigid:qMkM49oz3yjLGMFPbavHY8odtKA	false	necessary binding region:159-194,133-155|polyprotein fragment:33-511|mutation increasing interaction:168-168,171-171	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04578	uniprotkb:P04608	intact:EBI-6163496|uniprotkb:O09779	intact:EBI-6164389|uniprotkb:O09778	psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym)	psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cardaci et al. (2013)	pubmed:23916815|imex:IM-20959	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6899521|imex:IM-20959-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC	go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF	-	-	crc64:4DDC56D979769115	figure legend:f3|comment:"This assay showed that Tat binding to both V1- and V2-gp120 was as low as ~30%, compared to wild-type gp120. Remarkably, V1/V2-gp120 was almost completely unable to interact with Tat (Figure 3B)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/22	2014/10/16	rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706	rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706	intact-crc:46BA5277BB9F5CDB|rigid:qMkM49oz3yjLGMFPbavHY8odtKA	false	mutation increasing interaction:168-168|polyprotein fragment:33-511|necessary binding region:159-194,133-155	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)