#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q47730	uniprotkb:Q47730	intact:EBI-6912861|ensemblbacteria:AQL55117|ensemblbacteria:BBD29338|ensemblbacteria:OGX76421|ensemblbacteria:PQC68473	intact:EBI-6912861|ensemblbacteria:AQL55117|ensemblbacteria:BBD29338|ensemblbacteria:OGX76421|ensemblbacteria:PQC68473	psi-mi:q47730_entfl(display_long)|uniprotkb:EY666_08835(orf name)|uniprotkb:CUM81_08350(orf name)|uniprotkb:H7D67_09300(orf name)|uniprotkb:BZG32_16025(orf name)|uniprotkb:EGW70_06200(orf name)|uniprotkb:KUB3007_C27220(orf name)|uniprotkb:GTI81_09985(orf name)	psi-mi:q47730_entfl(display_long)|uniprotkb:EY666_08835(orf name)|uniprotkb:CUM81_08350(orf name)|uniprotkb:H7D67_09300(orf name)|uniprotkb:BZG32_16025(orf name)|uniprotkb:EGW70_06200(orf name)|uniprotkb:KUB3007_C27220(orf name)|uniprotkb:GTI81_09985(orf name)	psi-mi:"MI:0071"(molecular sieving)	Roberts et al. (2013)	pubmed:23910724|imex:IM-21317	taxid:1351(entfl)|taxid:1351(Enterococcus faecalis)	taxid:1351(entfl)|taxid:1351(Enterococcus faecalis)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6912845|imex:IM-21317-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AQL55117(transcript)|ensemblbacteria:BBD29338(transcript)|ensemblbacteria:BHU49_12890(gene)|ensemblbacteria:BZG32_16025(gene)|ensemblbacteria:CUN08_13135(gene)|ensemblbacteria:KUB3007_C27220(gene)|ensemblbacteria:OGX76421(transcript)|ensemblbacteria:PQC68473(transcript)|go:"GO:0042802"(identical protein binding)|refseq:WP_000342539.1|rcsb pdb:2W82|interpro:IPR009899(Antirestriction)|interpro:IPR041893|interpro:IPR041895|interpro:IPR041896	ensemblbacteria:AQL55117(transcript)|ensemblbacteria:BBD29338(transcript)|ensemblbacteria:BHU49_12890(gene)|ensemblbacteria:BZG32_16025(gene)|ensemblbacteria:CUN08_13135(gene)|ensemblbacteria:KUB3007_C27220(gene)|ensemblbacteria:OGX76421(transcript)|ensemblbacteria:PQC68473(transcript)|go:"GO:0042802"(identical protein binding)|refseq:WP_000342539.1|rcsb pdb:2W82|interpro:IPR009899(Antirestriction)|interpro:IPR041893|interpro:IPR041895|interpro:IPR041896	-	-	-	figure legend:f2 sf5|comment:"If the monomer-dimer  179 equilibrium model for ArdA is correct then it would appear that Mut5 and L127E ArdA are  180 monomers at most concentrations. The Mut6 protein behaved in the same manner as the wt Orf18  181 ArdA protein showing a decrease in apparent molecular mass as concentration decreased, Figure 2  182 (and Supplementary Figure S5d)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/31	2014/10/16	rogid:ERN0i4FJljAx/6EkEr08qWiyCi81351	rogid:ERN0i4FJljAx/6EkEr08qWiyCi81351	intact-crc:748D1A1AD2384D13|rigid:s71JS3kJoz6MJM6sT5L/iN9j3Uo	false	mutation disrupting interaction:109-109,115-115,111-112	mutation disrupting interaction:109-109,115-115,111-112	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q47730	uniprotkb:Q47730	intact:EBI-6912861|ensemblbacteria:AQL55117|ensemblbacteria:BBD29338|ensemblbacteria:OGX76421|ensemblbacteria:PQC68473	intact:EBI-6912861|ensemblbacteria:AQL55117|ensemblbacteria:BBD29338|ensemblbacteria:OGX76421|ensemblbacteria:PQC68473	psi-mi:q47730_entfl(display_long)|uniprotkb:EY666_08835(orf name)|uniprotkb:CUM81_08350(orf name)|uniprotkb:H7D67_09300(orf name)|uniprotkb:BZG32_16025(orf name)|uniprotkb:EGW70_06200(orf name)|uniprotkb:KUB3007_C27220(orf name)|uniprotkb:GTI81_09985(orf name)	psi-mi:q47730_entfl(display_long)|uniprotkb:EY666_08835(orf name)|uniprotkb:CUM81_08350(orf name)|uniprotkb:H7D67_09300(orf name)|uniprotkb:BZG32_16025(orf name)|uniprotkb:EGW70_06200(orf name)|uniprotkb:KUB3007_C27220(orf name)|uniprotkb:GTI81_09985(orf name)	psi-mi:"MI:0071"(molecular sieving)	Roberts et al. (2013)	pubmed:23910724|imex:IM-21317	taxid:1351(entfl)|taxid:1351(Enterococcus faecalis)	taxid:1351(entfl)|taxid:1351(Enterococcus faecalis)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6912873|imex:IM-21317-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AQL55117(transcript)|ensemblbacteria:BBD29338(transcript)|ensemblbacteria:BHU49_12890(gene)|ensemblbacteria:BZG32_16025(gene)|ensemblbacteria:CUN08_13135(gene)|ensemblbacteria:KUB3007_C27220(gene)|ensemblbacteria:OGX76421(transcript)|ensemblbacteria:PQC68473(transcript)|go:"GO:0042802"(identical protein binding)|refseq:WP_000342539.1|rcsb pdb:2W82|interpro:IPR009899(Antirestriction)|interpro:IPR041893|interpro:IPR041895|interpro:IPR041896	ensemblbacteria:AQL55117(transcript)|ensemblbacteria:BBD29338(transcript)|ensemblbacteria:BHU49_12890(gene)|ensemblbacteria:BZG32_16025(gene)|ensemblbacteria:CUN08_13135(gene)|ensemblbacteria:KUB3007_C27220(gene)|ensemblbacteria:OGX76421(transcript)|ensemblbacteria:PQC68473(transcript)|go:"GO:0042802"(identical protein binding)|refseq:WP_000342539.1|rcsb pdb:2W82|interpro:IPR009899(Antirestriction)|interpro:IPR041893|interpro:IPR041895|interpro:IPR041896	-	-	-	figure legend:f2 sf5|comment:"If the monomer-dimer  179 equilibrium model for ArdA is correct then it would appear that Mut5 and L127E ArdA are  180 monomers at most concentrations. The Mut6 protein behaved in the same manner as the wt Orf18  181 ArdA protein showing a decrease in apparent molecular mass as concentration decreased, Figure 2  182 (and Supplementary Figure S5d)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/31	2014/10/16	rogid:ERN0i4FJljAx/6EkEr08qWiyCi81351	rogid:ERN0i4FJljAx/6EkEr08qWiyCi81351	intact-crc:6B1703D218C57A14|rigid:s71JS3kJoz6MJM6sT5L/iN9j3Uo	false	mutation disrupting interaction:127-127	mutation disrupting interaction:127-127	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q47730	uniprotkb:Q47730	intact:EBI-6912861|ensemblbacteria:AQL55117|ensemblbacteria:BBD29338|ensemblbacteria:OGX76421|ensemblbacteria:PQC68473	intact:EBI-6912861|ensemblbacteria:AQL55117|ensemblbacteria:BBD29338|ensemblbacteria:OGX76421|ensemblbacteria:PQC68473	psi-mi:q47730_entfl(display_long)|uniprotkb:EY666_08835(orf name)|uniprotkb:CUM81_08350(orf name)|uniprotkb:H7D67_09300(orf name)|uniprotkb:BZG32_16025(orf name)|uniprotkb:EGW70_06200(orf name)|uniprotkb:KUB3007_C27220(orf name)|uniprotkb:GTI81_09985(orf name)	psi-mi:q47730_entfl(display_long)|uniprotkb:EY666_08835(orf name)|uniprotkb:CUM81_08350(orf name)|uniprotkb:H7D67_09300(orf name)|uniprotkb:BZG32_16025(orf name)|uniprotkb:EGW70_06200(orf name)|uniprotkb:KUB3007_C27220(orf name)|uniprotkb:GTI81_09985(orf name)	psi-mi:"MI:0028"(cosedimentation in solution)	Roberts et al. (2013)	pubmed:23910724|imex:IM-21317	taxid:1351(entfl)|taxid:1351(Enterococcus faecalis)	taxid:1351(entfl)|taxid:1351(Enterococcus faecalis)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6912886|imex:IM-21317-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AQL55117(transcript)|ensemblbacteria:BBD29338(transcript)|ensemblbacteria:BHU49_12890(gene)|ensemblbacteria:BZG32_16025(gene)|ensemblbacteria:CUN08_13135(gene)|ensemblbacteria:KUB3007_C27220(gene)|ensemblbacteria:OGX76421(transcript)|ensemblbacteria:PQC68473(transcript)|go:"GO:0042802"(identical protein binding)|refseq:WP_000342539.1|rcsb pdb:2W82|interpro:IPR009899(Antirestriction)|interpro:IPR041893|interpro:IPR041895|interpro:IPR041896	ensemblbacteria:AQL55117(transcript)|ensemblbacteria:BBD29338(transcript)|ensemblbacteria:BHU49_12890(gene)|ensemblbacteria:BZG32_16025(gene)|ensemblbacteria:CUN08_13135(gene)|ensemblbacteria:KUB3007_C27220(gene)|ensemblbacteria:OGX76421(transcript)|ensemblbacteria:PQC68473(transcript)|go:"GO:0042802"(identical protein binding)|refseq:WP_000342539.1|rcsb pdb:2W82|interpro:IPR009899(Antirestriction)|interpro:IPR041893|interpro:IPR041895|interpro:IPR041896	-	-	-	figure legend:f3 sf6 t2|comment:Individual analyses for L127E ArdA showed that the molecular mass changed with respect to concentration and the global analysis was inappropriate, Table 2. At low concentrations the molecular mass was between 21.2 and 17.0 kDa indicating that it is a monomer in solution at these concentrations|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/31	2014/10/16	rogid:ERN0i4FJljAx/6EkEr08qWiyCi81351	rogid:ERN0i4FJljAx/6EkEr08qWiyCi81351	intact-crc:8AF6EEB6911F7698|rigid:s71JS3kJoz6MJM6sT5L/iN9j3Uo	false	mutation disrupting interaction:109-109,115-115,111-112	mutation disrupting interaction:109-109,115-115,111-112	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q47730	uniprotkb:Q47730	intact:EBI-6912861|ensemblbacteria:AQL55117|ensemblbacteria:BBD29338|ensemblbacteria:OGX76421|ensemblbacteria:PQC68473	intact:EBI-6912861|ensemblbacteria:AQL55117|ensemblbacteria:BBD29338|ensemblbacteria:OGX76421|ensemblbacteria:PQC68473	psi-mi:q47730_entfl(display_long)|uniprotkb:EY666_08835(orf name)|uniprotkb:CUM81_08350(orf name)|uniprotkb:H7D67_09300(orf name)|uniprotkb:BZG32_16025(orf name)|uniprotkb:EGW70_06200(orf name)|uniprotkb:KUB3007_C27220(orf name)|uniprotkb:GTI81_09985(orf name)	psi-mi:q47730_entfl(display_long)|uniprotkb:EY666_08835(orf name)|uniprotkb:CUM81_08350(orf name)|uniprotkb:H7D67_09300(orf name)|uniprotkb:BZG32_16025(orf name)|uniprotkb:EGW70_06200(orf name)|uniprotkb:KUB3007_C27220(orf name)|uniprotkb:GTI81_09985(orf name)	psi-mi:"MI:0028"(cosedimentation in solution)	Roberts et al. (2013)	pubmed:23910724|imex:IM-21317	taxid:1351(entfl)|taxid:1351(Enterococcus faecalis)	taxid:1351(entfl)|taxid:1351(Enterococcus faecalis)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6912889|imex:IM-21317-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AQL55117(transcript)|ensemblbacteria:BBD29338(transcript)|ensemblbacteria:BHU49_12890(gene)|ensemblbacteria:BZG32_16025(gene)|ensemblbacteria:CUN08_13135(gene)|ensemblbacteria:KUB3007_C27220(gene)|ensemblbacteria:OGX76421(transcript)|ensemblbacteria:PQC68473(transcript)|go:"GO:0042802"(identical protein binding)|refseq:WP_000342539.1|rcsb pdb:2W82|interpro:IPR009899(Antirestriction)|interpro:IPR041893|interpro:IPR041895|interpro:IPR041896	ensemblbacteria:AQL55117(transcript)|ensemblbacteria:BBD29338(transcript)|ensemblbacteria:BHU49_12890(gene)|ensemblbacteria:BZG32_16025(gene)|ensemblbacteria:CUN08_13135(gene)|ensemblbacteria:KUB3007_C27220(gene)|ensemblbacteria:OGX76421(transcript)|ensemblbacteria:PQC68473(transcript)|go:"GO:0042802"(identical protein binding)|refseq:WP_000342539.1|rcsb pdb:2W82|interpro:IPR009899(Antirestriction)|interpro:IPR041893|interpro:IPR041895|interpro:IPR041896	-	-	-	figure legend:f3 sf6 t2|comment:Individual analyses for L127E ArdA showed that the molecular mass changed with respect to concentration and the global analysis was inappropriate, Table 2. At low concentrations the molecular mass was between 21.2 and 17.0 kDa indicating that it is a monomer in solution at these concentrations|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/31	2014/10/16	rogid:ERN0i4FJljAx/6EkEr08qWiyCi81351	rogid:ERN0i4FJljAx/6EkEr08qWiyCi81351	intact-crc:EC295B25760CC066|rigid:s71JS3kJoz6MJM6sT5L/iN9j3Uo	false	mutation disrupting interaction:127-127	mutation disrupting interaction:127-127	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)