#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O75419	uniprotkb:Q9HAW4	intact:EBI-374969|uniprotkb:O60856|uniprotkb:Q6UW54|uniprotkb:Q9UP68|ensembl:ENSP00000263201|uniprotkb:Q20WK8|uniprotkb:B4DDB4|uniprotkb:B4DDU3|uniprotkb:E9PDH7	intact:EBI-1369377|uniprotkb:Q5VYG0|uniprotkb:Q6P6H5|uniprotkb:Q8IWI1|uniprotkb:A6NFL4|uniprotkb:Q1RMC6|uniprotkb:Q2KHM3|intact:EBI-28979386|ensembl:ENSP00000312995	psi-mi:cdc45_human(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:CDC45L2(gene name synonym)|uniprotkb:UNQ374/PRO710(orf name)|uniprotkb:PORC-PI-1(gene name synonym)|uniprotkb:CDC45L(gene name synonym)	psi-mi:clspn_human(display_long)|uniprotkb:CLSPN(gene name)|psi-mi:CLSPN(display_short)	psi-mi:"MI:0096"(pull down)	Broderick et al. (2013)	pubmed:23910567|imex:IM-21321	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6914747|imex:IM-21321-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000093009(gene)|ensembl:ENST00000263201(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0036064"(ciliary basal body)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:5DGO|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:XP_011528717.1|refseq:XP_011528720.1|refseq:NP_001171481.1|refseq:NP_001171482.1|refseq:NP_003495.1|refseq:XP_005261342.1|dip:DIP-31725N	refseq:NP_001317419.1|ensembl:ENST00000251195|ensembl:ENSP00000251195|ensembl:ENSP00000312995|ensembl:ENST00000373220|ensembl:ENSP00000362317|refseq:NP_001177410.1|refseq:NP_071394.2|ensembl:ENSG00000092853(gene)|ensembl:ENST00000318121(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000217"(DNA secondary structure binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|interpro:IPR024146|mint:Q9HAW4|rcsb pdb:7AKO|reactome:R-HSA-111465|reactome:R-HSA-176187|reactome:R-HSA-5689880|reactome:R-HSA-5693607	-	-	-	figure legend:f1a f4b f5b f6b f6d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line)	-	2013/08/04	2014/10/16	rogid:KAtvS0oWXb014gPzeXSlSKncUPM9606	rogid:colqtYH36pqL6fhGk1RHAf8UJVU9606	intact-crc:72B896611AAC062C|rigid:wX/lPzYol8MLOQlHB7tbM3Tkddo	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15927	uniprotkb:O75419	intact:EBI-621404|ensembl:ENSP00000363021|uniprotkb:Q52II0|uniprotkb:Q5TEI9|uniprotkb:Q5TEJ5	intact:EBI-374969|uniprotkb:O60856|uniprotkb:Q6UW54|uniprotkb:Q9UP68|ensembl:ENSP00000263201|uniprotkb:Q20WK8|uniprotkb:B4DDB4|uniprotkb:B4DDU3|uniprotkb:E9PDH7	psi-mi:rfa2_human(display_long)|uniprotkb:RPA34(gene name synonym)|uniprotkb:Replication protein A 34 kDa subunit(gene name synonym)|uniprotkb:Replication factor A protein 2(gene name synonym)|uniprotkb:RPA2(gene name)|psi-mi:RPA2(display_short)|uniprotkb:REPA2(gene name synonym)|uniprotkb:RPA32(gene name synonym)	psi-mi:cdc45_human(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:CDC45L2(gene name synonym)|uniprotkb:UNQ374/PRO710(orf name)|uniprotkb:PORC-PI-1(gene name synonym)|uniprotkb:CDC45L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Broderick et al. (2013)	pubmed:23910567|imex:IM-21321	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6914769|imex:IM-21321-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:1Z1D|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|rcsb pdb:4MQV|rcsb pdb:4OU0|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|rcsb pdb:1DPU|ensembl:ENSG00000117748(gene)|ensembl:ENST00000373912(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|mint:P15927|refseq:NP_001273005.1|refseq:NP_002937.1|refseq:NP_001284487.1|dip:DIP-24187N	ensembl:ENSG00000093009(gene)|ensembl:ENST00000263201(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0036064"(ciliary basal body)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:5DGO|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:XP_011528717.1|refseq:XP_011528720.1|refseq:NP_001171481.1|refseq:NP_001171482.1|refseq:NP_003495.1|refseq:XP_005261342.1|dip:DIP-31725N	-	-	-	figure legend:f1c f4d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line)	-	2013/08/04	2014/10/16	rogid:+Ute8Lq5hnN0sLAQNWZb0cAbcTI9606	rogid:KAtvS0oWXb014gPzeXSlSKncUPM9606	intact-crc:811BDA3E6ADA8372|rigid:ZP8ZK+5p/thj5YQpAsCKWk6hCqg	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75419	uniprotkb:P15927	intact:EBI-374969|uniprotkb:O60856|uniprotkb:Q6UW54|uniprotkb:Q9UP68|ensembl:ENSP00000263201|uniprotkb:Q20WK8|uniprotkb:B4DDB4|uniprotkb:B4DDU3|uniprotkb:E9PDH7	intact:EBI-621404|ensembl:ENSP00000363021|uniprotkb:Q52II0|uniprotkb:Q5TEI9|uniprotkb:Q5TEJ5	psi-mi:cdc45_human(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:CDC45L2(gene name synonym)|uniprotkb:UNQ374/PRO710(orf name)|uniprotkb:PORC-PI-1(gene name synonym)|uniprotkb:CDC45L(gene name synonym)	psi-mi:rfa2_human(display_long)|uniprotkb:RPA34(gene name synonym)|uniprotkb:Replication protein A 34 kDa subunit(gene name synonym)|uniprotkb:Replication factor A protein 2(gene name synonym)|uniprotkb:RPA2(gene name)|psi-mi:RPA2(display_short)|uniprotkb:REPA2(gene name synonym)|uniprotkb:RPA32(gene name synonym)	psi-mi:"MI:0096"(pull down)	Broderick et al. (2013)	pubmed:23910567|imex:IM-21321	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6914791|imex:IM-21321-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000093009(gene)|ensembl:ENST00000263201(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0036064"(ciliary basal body)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:5DGO|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:XP_011528717.1|refseq:XP_011528720.1|refseq:NP_001171481.1|refseq:NP_001171482.1|refseq:NP_003495.1|refseq:XP_005261342.1|dip:DIP-31725N	rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:1Z1D|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|rcsb pdb:4MQV|rcsb pdb:4OU0|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|rcsb pdb:1DPU|ensembl:ENSG00000117748(gene)|ensembl:ENST00000373912(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|mint:P15927|refseq:NP_001273005.1|refseq:NP_002937.1|refseq:NP_001284487.1|dip:DIP-24187N	-	-	-	figure legend:f2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line)	-	2013/08/04	2014/10/16	rogid:KAtvS0oWXb014gPzeXSlSKncUPM9606	rogid:+Ute8Lq5hnN0sLAQNWZb0cAbcTI9606	intact-crc:5A2A5C552C3BA743|rigid:If2zRraCwWTjeqokOpqxaAAplcY	false	flag tag:?-?|binding-associated region:488-566	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75419	uniprotkb:Q9HAW4	intact:EBI-374969|uniprotkb:O60856|uniprotkb:Q6UW54|uniprotkb:Q9UP68|ensembl:ENSP00000263201|uniprotkb:Q20WK8|uniprotkb:B4DDB4|uniprotkb:B4DDU3|uniprotkb:E9PDH7	intact:EBI-1369377|uniprotkb:Q5VYG0|uniprotkb:Q6P6H5|uniprotkb:Q8IWI1|uniprotkb:A6NFL4|uniprotkb:Q1RMC6|uniprotkb:Q2KHM3|intact:EBI-28979386|ensembl:ENSP00000312995	psi-mi:cdc45_human(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:CDC45L2(gene name synonym)|uniprotkb:UNQ374/PRO710(orf name)|uniprotkb:PORC-PI-1(gene name synonym)|uniprotkb:CDC45L(gene name synonym)	psi-mi:clspn_human(display_long)|uniprotkb:CLSPN(gene name)|psi-mi:CLSPN(display_short)	psi-mi:"MI:0096"(pull down)	Broderick et al. (2013)	pubmed:23910567|imex:IM-21321	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6914791|imex:IM-21321-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000093009(gene)|ensembl:ENST00000263201(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0036064"(ciliary basal body)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:5DGO|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:XP_011528717.1|refseq:XP_011528720.1|refseq:NP_001171481.1|refseq:NP_001171482.1|refseq:NP_003495.1|refseq:XP_005261342.1|dip:DIP-31725N	refseq:NP_001317419.1|ensembl:ENST00000251195|ensembl:ENSP00000251195|ensembl:ENSP00000312995|ensembl:ENST00000373220|ensembl:ENSP00000362317|refseq:NP_001177410.1|refseq:NP_071394.2|ensembl:ENSG00000092853(gene)|ensembl:ENST00000318121(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000217"(DNA secondary structure binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|interpro:IPR024146|mint:Q9HAW4|rcsb pdb:7AKO|reactome:R-HSA-111465|reactome:R-HSA-176187|reactome:R-HSA-5689880|reactome:R-HSA-5693607	-	-	-	figure legend:f2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line)	-	2013/08/04	2014/10/16	rogid:KAtvS0oWXb014gPzeXSlSKncUPM9606	rogid:colqtYH36pqL6fhGk1RHAf8UJVU9606	intact-crc:5A2A5C552C3BA743|rigid:If2zRraCwWTjeqokOpqxaAAplcY	false	flag tag:?-?|binding-associated region:488-566	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15927	uniprotkb:O75419	intact:EBI-621404|ensembl:ENSP00000363021|uniprotkb:Q52II0|uniprotkb:Q5TEI9|uniprotkb:Q5TEJ5	intact:EBI-374969|uniprotkb:O60856|uniprotkb:Q6UW54|uniprotkb:Q9UP68|ensembl:ENSP00000263201|uniprotkb:Q20WK8|uniprotkb:B4DDB4|uniprotkb:B4DDU3|uniprotkb:E9PDH7	psi-mi:rfa2_human(display_long)|uniprotkb:RPA34(gene name synonym)|uniprotkb:Replication protein A 34 kDa subunit(gene name synonym)|uniprotkb:Replication factor A protein 2(gene name synonym)|uniprotkb:RPA2(gene name)|psi-mi:RPA2(display_short)|uniprotkb:REPA2(gene name synonym)|uniprotkb:RPA32(gene name synonym)	psi-mi:cdc45_human(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:CDC45L2(gene name synonym)|uniprotkb:UNQ374/PRO710(orf name)|uniprotkb:PORC-PI-1(gene name synonym)|uniprotkb:CDC45L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Broderick et al. (2013)	pubmed:23910567|imex:IM-21321	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6914777|imex:IM-21321-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:1Z1D|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|rcsb pdb:4MQV|rcsb pdb:4OU0|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|rcsb pdb:1DPU|ensembl:ENSG00000117748(gene)|ensembl:ENST00000373912(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|mint:P15927|refseq:NP_001273005.1|refseq:NP_002937.1|refseq:NP_001284487.1|dip:DIP-24187N	ensembl:ENSG00000093009(gene)|ensembl:ENST00000263201(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0036064"(ciliary basal body)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:5DGO|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:XP_011528717.1|refseq:XP_011528720.1|refseq:NP_001171481.1|refseq:NP_001171482.1|refseq:NP_003495.1|refseq:XP_005261342.1|dip:DIP-31725N	-	-	-	figure legend:f1d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line)	-	2013/08/04	2014/10/16	rogid:+Ute8Lq5hnN0sLAQNWZb0cAbcTI9606	rogid:KAtvS0oWXb014gPzeXSlSKncUPM9606	intact-crc:7C4E4EF823A7FD83|rigid:ZP8ZK+5p/thj5YQpAsCKWk6hCqg	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HAW4	uniprotkb:O75419	intact:EBI-1369377|uniprotkb:Q5VYG0|uniprotkb:Q6P6H5|uniprotkb:Q8IWI1|uniprotkb:A6NFL4|uniprotkb:Q1RMC6|uniprotkb:Q2KHM3|intact:EBI-28979386|ensembl:ENSP00000312995	intact:EBI-374969|uniprotkb:O60856|uniprotkb:Q6UW54|uniprotkb:Q9UP68|ensembl:ENSP00000263201|uniprotkb:Q20WK8|uniprotkb:B4DDB4|uniprotkb:B4DDU3|uniprotkb:E9PDH7	psi-mi:clspn_human(display_long)|uniprotkb:CLSPN(gene name)|psi-mi:CLSPN(display_short)	psi-mi:cdc45_human(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:CDC45L2(gene name synonym)|uniprotkb:UNQ374/PRO710(orf name)|uniprotkb:PORC-PI-1(gene name synonym)|uniprotkb:CDC45L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Broderick et al. (2013)	pubmed:23910567|imex:IM-21321	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6914761|imex:IM-21321-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001317419.1|ensembl:ENST00000251195|ensembl:ENSP00000251195|ensembl:ENSP00000312995|ensembl:ENST00000373220|ensembl:ENSP00000362317|refseq:NP_001177410.1|refseq:NP_071394.2|ensembl:ENSG00000092853(gene)|ensembl:ENST00000318121(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000217"(DNA secondary structure binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|interpro:IPR024146|mint:Q9HAW4|rcsb pdb:7AKO|reactome:R-HSA-111465|reactome:R-HSA-176187|reactome:R-HSA-5689880|reactome:R-HSA-5693607	ensembl:ENSG00000093009(gene)|ensembl:ENST00000263201(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0036064"(ciliary basal body)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:5DGO|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:XP_011528717.1|refseq:XP_011528720.1|refseq:NP_001171481.1|refseq:NP_001171482.1|refseq:NP_003495.1|refseq:XP_005261342.1|dip:DIP-31725N	-	-	-	figure legend:f1b f4e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela_s3)|taxid:9606(Homo sapiens HeLa-S3 cervix carcinoma cell line)	-	2013/08/04	2014/10/16	rogid:colqtYH36pqL6fhGk1RHAf8UJVU9606	rogid:KAtvS0oWXb014gPzeXSlSKncUPM9606	intact-crc:41895E6869DB9053|rigid:wX/lPzYol8MLOQlHB7tbM3Tkddo	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75419	uniprotkb:P15927	intact:EBI-374969|uniprotkb:O60856|uniprotkb:Q6UW54|uniprotkb:Q9UP68|ensembl:ENSP00000263201|uniprotkb:Q20WK8|uniprotkb:B4DDB4|uniprotkb:B4DDU3|uniprotkb:E9PDH7	intact:EBI-621404|ensembl:ENSP00000363021|uniprotkb:Q52II0|uniprotkb:Q5TEI9|uniprotkb:Q5TEJ5	psi-mi:cdc45_human(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:CDC45L2(gene name synonym)|uniprotkb:UNQ374/PRO710(orf name)|uniprotkb:PORC-PI-1(gene name synonym)|uniprotkb:CDC45L(gene name synonym)	psi-mi:rfa2_human(display_long)|uniprotkb:RPA34(gene name synonym)|uniprotkb:Replication protein A 34 kDa subunit(gene name synonym)|uniprotkb:Replication factor A protein 2(gene name synonym)|uniprotkb:RPA2(gene name)|psi-mi:RPA2(display_short)|uniprotkb:REPA2(gene name synonym)|uniprotkb:RPA32(gene name synonym)	psi-mi:"MI:0096"(pull down)	Broderick et al. (2013)	pubmed:23910567|imex:IM-21321	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6914803|imex:IM-21321-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000093009(gene)|ensembl:ENST00000263201(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0036064"(ciliary basal body)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:5DGO|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:XP_011528717.1|refseq:XP_011528720.1|refseq:NP_001171481.1|refseq:NP_001171482.1|refseq:NP_003495.1|refseq:XP_005261342.1|dip:DIP-31725N	rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:1Z1D|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|rcsb pdb:4MQV|rcsb pdb:4OU0|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|rcsb pdb:1DPU|ensembl:ENSG00000117748(gene)|ensembl:ENST00000373912(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|mint:P15927|refseq:NP_001273005.1|refseq:NP_002937.1|refseq:NP_001284487.1|dip:DIP-24187N	-	-	-	figure legend:f3c|comment:"similar amounts of FLAG-Cdc45 were immunoprecipitated from extracts of  these elutriated cells (Figure 3C). From these elutriated cells, FLAG-Cdc45 bound a  maximal amount of p125 of Pol δ from extracts of cells enriched in S phase (Figure 3C),  which is consistent with previously described findings studying thymidine-arrested and  released cells [19]. These results supported the functional activity of the FLAG-Cdc45.  The western blots of the FLAG-affinity pull-downs showed that FLAG-Cdc45 co-  immunoprecipitated Claspin and RPA32 maximally from cells enriched in S phase of  the cell cycle (Figure 3C)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2013/08/04	2014/10/16	rogid:KAtvS0oWXb014gPzeXSlSKncUPM9606	rogid:+Ute8Lq5hnN0sLAQNWZb0cAbcTI9606	intact-crc:4F3D304A0C90CFFC|rigid:sf6l+tGTyyoyK80/gj9w093NKTM	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75419	uniprotkb:P28340	intact:EBI-374969|uniprotkb:O60856|uniprotkb:Q6UW54|uniprotkb:Q9UP68|ensembl:ENSP00000263201|uniprotkb:Q20WK8|uniprotkb:B4DDB4|uniprotkb:B4DDU3|uniprotkb:E9PDH7	intact:EBI-716569|uniprotkb:Q8NER3|uniprotkb:Q96H98|ensembl:ENSP00000406046|ensembl:ENSP00000472600|ensembl:ENSP00000473052	psi-mi:cdc45_human(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:CDC45L2(gene name synonym)|uniprotkb:UNQ374/PRO710(orf name)|uniprotkb:PORC-PI-1(gene name synonym)|uniprotkb:CDC45L(gene name synonym)	psi-mi:dpod1_human(display_long)|uniprotkb:3'-5' exodeoxyribonuclease(gene name synonym)|uniprotkb:DNA polymerase subunit delta p125(gene name synonym)|uniprotkb:POLD1(gene name)|psi-mi:POLD1(display_short)|uniprotkb:POLD(gene name synonym)	psi-mi:"MI:0096"(pull down)	Broderick et al. (2013)	pubmed:23910567|imex:IM-21321	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6914803|imex:IM-21321-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000093009(gene)|ensembl:ENST00000263201(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0036064"(ciliary basal body)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:5DGO|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:XP_011528717.1|refseq:XP_011528720.1|refseq:NP_001171481.1|refseq:NP_001171482.1|refseq:NP_003495.1|refseq:XP_005261342.1|dip:DIP-31725N	refseq:NP_002682.2|refseq:XP_011525340.1|refseq:NP_001243778.1|ensembl:ENSG00000062822(gene)|ensembl:ENST00000599857(transcript)|ensembl:ENST00000601098(transcript)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0009411"(response to UV)|ensembl:ENST00000440232(transcript)|reactome:R-HSA-5651801|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-5358606|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0019899"(enzyme binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0043625"(delta DNA polymerase complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017964|interpro:IPR023211|interpro:IPR025687|interpro:IPR036397|interpro:IPR042087|interpro:IPR043502|mint:P28340|rcsb pdb:6S1M|rcsb pdb:6S1N|rcsb pdb:6S1O|rcsb pdb:6TNY|rcsb pdb:6TNZ|reactome:R-HSA-110314|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174437|reactome:R-HSA-2564830|reactome:R-HSA-5358565|refseq:XP_016882370.1	-	-	-	figure legend:f3c|comment:"similar amounts of FLAG-Cdc45 were immunoprecipitated from extracts of  these elutriated cells (Figure 3C). From these elutriated cells, FLAG-Cdc45 bound a  maximal amount of p125 of Pol δ from extracts of cells enriched in S phase (Figure 3C),  which is consistent with previously described findings studying thymidine-arrested and  released cells [19]. These results supported the functional activity of the FLAG-Cdc45.  The western blots of the FLAG-affinity pull-downs showed that FLAG-Cdc45 co-  immunoprecipitated Claspin and RPA32 maximally from cells enriched in S phase of  the cell cycle (Figure 3C)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2013/08/04	2014/10/16	rogid:KAtvS0oWXb014gPzeXSlSKncUPM9606	rogid:bJ5Q0xOzHga/zxMOBHkuXaFXeLw9606	intact-crc:4F3D304A0C90CFFC|rigid:sf6l+tGTyyoyK80/gj9w093NKTM	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75419	uniprotkb:Q9HAW4	intact:EBI-374969|uniprotkb:O60856|uniprotkb:Q6UW54|uniprotkb:Q9UP68|ensembl:ENSP00000263201|uniprotkb:Q20WK8|uniprotkb:B4DDB4|uniprotkb:B4DDU3|uniprotkb:E9PDH7	intact:EBI-1369377|uniprotkb:Q5VYG0|uniprotkb:Q6P6H5|uniprotkb:Q8IWI1|uniprotkb:A6NFL4|uniprotkb:Q1RMC6|uniprotkb:Q2KHM3|intact:EBI-28979386|ensembl:ENSP00000312995	psi-mi:cdc45_human(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:CDC45L2(gene name synonym)|uniprotkb:UNQ374/PRO710(orf name)|uniprotkb:PORC-PI-1(gene name synonym)|uniprotkb:CDC45L(gene name synonym)	psi-mi:clspn_human(display_long)|uniprotkb:CLSPN(gene name)|psi-mi:CLSPN(display_short)	psi-mi:"MI:0096"(pull down)	Broderick et al. (2013)	pubmed:23910567|imex:IM-21321	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6914803|imex:IM-21321-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000093009(gene)|ensembl:ENST00000263201(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0036064"(ciliary basal body)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:5DGO|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:XP_011528717.1|refseq:XP_011528720.1|refseq:NP_001171481.1|refseq:NP_001171482.1|refseq:NP_003495.1|refseq:XP_005261342.1|dip:DIP-31725N	refseq:NP_001317419.1|ensembl:ENST00000251195|ensembl:ENSP00000251195|ensembl:ENSP00000312995|ensembl:ENST00000373220|ensembl:ENSP00000362317|refseq:NP_001177410.1|refseq:NP_071394.2|ensembl:ENSG00000092853(gene)|ensembl:ENST00000318121(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000217"(DNA secondary structure binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|interpro:IPR024146|mint:Q9HAW4|rcsb pdb:7AKO|reactome:R-HSA-111465|reactome:R-HSA-176187|reactome:R-HSA-5689880|reactome:R-HSA-5693607	-	-	-	figure legend:f3c|comment:"similar amounts of FLAG-Cdc45 were immunoprecipitated from extracts of  these elutriated cells (Figure 3C). From these elutriated cells, FLAG-Cdc45 bound a  maximal amount of p125 of Pol δ from extracts of cells enriched in S phase (Figure 3C),  which is consistent with previously described findings studying thymidine-arrested and  released cells [19]. These results supported the functional activity of the FLAG-Cdc45.  The western blots of the FLAG-affinity pull-downs showed that FLAG-Cdc45 co-  immunoprecipitated Claspin and RPA32 maximally from cells enriched in S phase of  the cell cycle (Figure 3C)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2013/08/04	2014/10/16	rogid:KAtvS0oWXb014gPzeXSlSKncUPM9606	rogid:colqtYH36pqL6fhGk1RHAf8UJVU9606	intact-crc:4F3D304A0C90CFFC|rigid:sf6l+tGTyyoyK80/gj9w093NKTM	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)