#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:75947"	uniprotkb:Q86WV6	intact:EBI-8801022	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:"cg(2'5')_pa(3'5')p"(display_short)|psi-mi:"CHEBI:75947"(display_long)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Gao et al. (2013)	pubmed:23910378	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8795658	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	-	-	-	figure legend:Fig. 4A, 4B, 4C, Supp. Table 3, 4|causality statement:"CHEBI:75947 increases activity of Q86WV6"	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.3x10^-6(molar)	2013/10/15	2014/10/16	-	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:A6541CF22E9E4375	false	-	sufficient binding region:140-379|mutation disrupting interaction strength:238-238|mutation disrupting interaction strength:240-240|mutation disrupting interaction strength:242-242|mutation decreasing interaction strength:260-260|mutation decreasing interaction strength:162-162|mutation decreasing interaction strength:263-263|mutation increasing interaction strength:232-232	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:75948"	uniprotkb:Q86WV6	intact:EBI-8801024	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:"cg(2'5')_pa(2'5')p"(display_short)|psi-mi:"CHEBI:75948"(display_long)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Gao et al. (2013)	pubmed:23910378	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8801106	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	-	-	-	comment:"The 2′,5′-containing linkage isomers of cGAMP exhibited increased binding affinity by aboutan order of magnitude for STING variants with R232 compared to H232. Endothermic titration patterns were observed for all binding curves, except for an exothermic titration pattern for c[G(3′,5′)pA(3′,5′)p] with hSTINGR232"|figure legend:Fig. 4A, C, D, Supp. Table 3|causality statement:"CHEBI:75948 increases activity of Q86WV6"	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.5x10^-6(molar)	2013/10/15	2014/10/16	-	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:665A05F1DAA78E80	false	-	mutation increasing interaction strength:230-230,232-232|mutation increasing interaction strength:232-232|sufficient binding region:140-379	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:71580"	uniprotkb:Q86WV6	intact:EBI-8795293	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:c-gmp-amp(display_short)|psi-mi:"CHEBI:71580"(display_long)|intact:3',5'-cyclic GMP-AMP(synonym)|intact:cyclic GMP-AMP(synonym)|intact:"2-amino-9-[(2R,3R,3aS,7aR,9R,10R,10aS,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one"(iupac name)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Gao et al. (2013)	pubmed:23910378	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8795673	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	-	inchi key:RFCBNSCSPXMEBK-INFSMZHSSA-N	-	comment:"The 3′,5′-containing linkage isomers of cGAMP exhibited increased binding affinity by about 4-fold for STING variants with R232 compared to H232. Endothermic titration patterns were observed for all binding curves, except for an exothermic titration pattern for c[G(3′,5′)pA(3′,5′)p] with hSTINGR232"|figure legend:Fig. 4A, C, D, Supp. Table 3|causality statement:"CHEBI:71580 increases activity of Q86WV6"	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.4x10^-6(molar)	2013/10/15	2014/10/16	-	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:4DE36ECBEC0FDE16	false	-	sufficient binding region:140-379|mutation increasing interaction strength:232-232|mutation increasing interaction strength:230-230,232-232	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:75934"	uniprotkb:Q86WV6	intact:EBI-8795414	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:dmxaa(display_short)|psi-mi:"CHEBI:75934"(display_long)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Gao et al. (2013)	pubmed:23910378	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8801269	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	-	-	-	figure legend:Fig. 7F, 7G	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/15	2014/10/16	-	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:DEF6DC4C50199320	false	-	mutation:232-232|sufficient binding region:140-379	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:75947"	uniprotkb:Q3TBT3	intact:EBI-8801022	intact:EBI-3862093|uniprotkb:A7YGY9|uniprotkb:Q3TAV5|uniprotkb:Q3TYP5|uniprotkb:Q3TZY8|uniprotkb:Q3UJW3|uniprotkb:Q8C227|uniprotkb:Q8C5Q3|uniprotkb:Q8K393|uniprotkb:Q9CZY7|ensembl:ENSMUSP00000111393|ensembl:ENSMUSP00000157408	psi-mi:"cg(2'5')_pa(3'5')p"(display_short)|psi-mi:"CHEBI:75947"(display_long)	psi-mi:sting_mouse(display_long)|uniprotkb:Sting1(gene name)|psi-mi:Sting1(display_short)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:Eris(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:Mita(gene name synonym)|uniprotkb:Mpys(gene name synonym)|uniprotkb:Tmem173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Gao et al. (2013)	pubmed:23910378	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8795668	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001276520.1|refseq:NP_001276521.1|refseq:NP_082537.1|dip:DIP-59959N|ensembl:ENSMUSG00000024349(gene)|ensembl:ENSMUST00000115728(transcript)|ensembl:ENSMUST00000237919(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4JC5|rcsb pdb:4KBY|rcsb pdb:4KC0|rcsb pdb:4LOJ|rcsb pdb:4LOK|rcsb pdb:4LOL|rcsb pdb:4YP1|rcsb pdb:6XNN|reactome:R-MMU-1834941|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-6798695|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)	-	-	-	figure legend:Fig. 4F Supp Table 3|causality statement:"CHEBI:75947 increases activity of Q3TBT3"	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.4x10^-7	2013/10/15	2014/10/16	-	rogid:n8idTbDnMp6Sw5To/kS19oCCAF010090	intact-crc:E6612ADB2BEB12F9	false	-	sufficient binding region:139-378|mutation:231-231	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:71580"	uniprotkb:Q3TBT3	intact:EBI-8795293	intact:EBI-3862093|uniprotkb:A7YGY9|uniprotkb:Q3TAV5|uniprotkb:Q3TYP5|uniprotkb:Q3TZY8|uniprotkb:Q3UJW3|uniprotkb:Q8C227|uniprotkb:Q8C5Q3|uniprotkb:Q8K393|uniprotkb:Q9CZY7|ensembl:ENSMUSP00000111393|ensembl:ENSMUSP00000157408	psi-mi:c-gmp-amp(display_short)|psi-mi:"CHEBI:71580"(display_long)|intact:3',5'-cyclic GMP-AMP(synonym)|intact:cyclic GMP-AMP(synonym)|intact:"2-amino-9-[(2R,3R,3aS,7aR,9R,10R,10aS,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one"(iupac name)	psi-mi:sting_mouse(display_long)|uniprotkb:Sting1(gene name)|psi-mi:Sting1(display_short)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:Eris(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:Mita(gene name synonym)|uniprotkb:Mpys(gene name synonym)|uniprotkb:Tmem173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Gao et al. (2013)	pubmed:23910378	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8795663	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001276520.1|refseq:NP_001276521.1|refseq:NP_082537.1|dip:DIP-59959N|ensembl:ENSMUSG00000024349(gene)|ensembl:ENSMUST00000115728(transcript)|ensembl:ENSMUST00000237919(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4JC5|rcsb pdb:4KBY|rcsb pdb:4KC0|rcsb pdb:4LOJ|rcsb pdb:4LOK|rcsb pdb:4LOL|rcsb pdb:4YP1|rcsb pdb:6XNN|reactome:R-MMU-1834941|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-6798695|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)	-	inchi key:RFCBNSCSPXMEBK-INFSMZHSSA-N	-	figure legend:Fig. 4F, Supp Table 3|causality statement:"CHEBI:71580 increases activity of Q3TBT3"	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.6x10^-7(molar)	2013/10/15	2014/10/16	-	rogid:n8idTbDnMp6Sw5To/kS19oCCAF010090	intact-crc:755EE9C908C10931	false	-	sufficient binding region:139-378|mutation decreasing interaction strength:231-231	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:75948"	uniprotkb:Q3TBT3	intact:EBI-8801024	intact:EBI-3862093|uniprotkb:A7YGY9|uniprotkb:Q3TAV5|uniprotkb:Q3TYP5|uniprotkb:Q3TZY8|uniprotkb:Q3UJW3|uniprotkb:Q8C227|uniprotkb:Q8C5Q3|uniprotkb:Q8K393|uniprotkb:Q9CZY7|ensembl:ENSMUSP00000111393|ensembl:ENSMUSP00000157408	psi-mi:"cg(2'5')_pa(2'5')p"(display_short)|psi-mi:"CHEBI:75948"(display_long)	psi-mi:sting_mouse(display_long)|uniprotkb:Sting1(gene name)|psi-mi:Sting1(display_short)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:Eris(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:Mita(gene name synonym)|uniprotkb:Mpys(gene name synonym)|uniprotkb:Tmem173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Gao et al. (2013)	pubmed:23910378	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8801235	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001276520.1|refseq:NP_001276521.1|refseq:NP_082537.1|dip:DIP-59959N|ensembl:ENSMUSG00000024349(gene)|ensembl:ENSMUST00000115728(transcript)|ensembl:ENSMUST00000237919(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4JC5|rcsb pdb:4KBY|rcsb pdb:4KC0|rcsb pdb:4LOJ|rcsb pdb:4LOK|rcsb pdb:4LOL|rcsb pdb:4YP1|rcsb pdb:6XNN|reactome:R-MMU-1834941|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-6798695|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)	-	-	-	figure legend:Fig. 4E Supp Table 3|causality statement:"CHEBI:75948 increases activity of Q3TBT3"	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.8x10^-7	2013/10/15	2014/10/16	-	rogid:n8idTbDnMp6Sw5To/kS19oCCAF010090	intact-crc:BA300A65A54F293E	false	-	sufficient binding region:139-378	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:75934"	uniprotkb:Q3TBT3	intact:EBI-8795414	intact:EBI-3862093|uniprotkb:A7YGY9|uniprotkb:Q3TAV5|uniprotkb:Q3TYP5|uniprotkb:Q3TZY8|uniprotkb:Q3UJW3|uniprotkb:Q8C227|uniprotkb:Q8C5Q3|uniprotkb:Q8K393|uniprotkb:Q9CZY7|ensembl:ENSMUSP00000111393|ensembl:ENSMUSP00000157408	psi-mi:dmxaa(display_short)|psi-mi:"CHEBI:75934"(display_long)	psi-mi:sting_mouse(display_long)|uniprotkb:Sting1(gene name)|psi-mi:Sting1(display_short)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:Eris(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:Mita(gene name synonym)|uniprotkb:Mpys(gene name synonym)|uniprotkb:Tmem173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Gao et al. (2013)	pubmed:23910378	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8801258	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001276520.1|refseq:NP_001276521.1|refseq:NP_082537.1|dip:DIP-59959N|ensembl:ENSMUSG00000024349(gene)|ensembl:ENSMUST00000115728(transcript)|ensembl:ENSMUST00000237919(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4JC5|rcsb pdb:4KBY|rcsb pdb:4KC0|rcsb pdb:4LOJ|rcsb pdb:4LOK|rcsb pdb:4LOL|rcsb pdb:4YP1|rcsb pdb:6XNN|reactome:R-MMU-1834941|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-6798695|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)	-	-	-	figure legend:Fig. 7E|causality statement:"CHEBI:75934 increases activity of Q3TBT3"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/15	2014/10/16	-	rogid:n8idTbDnMp6Sw5To/kS19oCCAF010090	intact-crc:6FDD306022B2BF98	false	-	sufficient binding region:139-378	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:75948"	uniprotkb:Q86WV6	intact:EBI-8801024	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:"cg(2'5')_pa(2'5')p"(display_short)|psi-mi:"CHEBI:75948"(display_long)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Gao et al. (2013)	pubmed:23910378	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8795301|wwpdb:4loi	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	-	-	-	3d-resolution:1.89A|3d-r-factors:Rworking = 0.18 Rfree = 0.2|figure legend:Supp. Table 1|causality statement:"CHEBI:75948 increases activity of Q86WV6"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/15	2014/10/16	-	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:708580FA9C27557B	false	-	sufficient binding region:155-341	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:75947"	uniprotkb:Q86WV6	intact:EBI-8801022	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:"cg(2'5')_pa(3'5')p"(display_short)|psi-mi:"CHEBI:75947"(display_long)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Gao et al. (2013)	pubmed:23910378	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8795178|wwpdb:4loh	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	-	-	-	3d-resolution:2.25A|3d-r-factors:Rworking = 0.19 Rfree = 0.22|figure legend:Supp. Table 1|causality statement:"CHEBI:75947 increases activity of Q86WV6"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/15	2014/10/16	-	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:A21D902A28113E1C	false	-	sufficient binding region:155-341	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:75934"	uniprotkb:Q3TBT3	intact:EBI-8795414	intact:EBI-3862093|uniprotkb:A7YGY9|uniprotkb:Q3TAV5|uniprotkb:Q3TYP5|uniprotkb:Q3TZY8|uniprotkb:Q3UJW3|uniprotkb:Q8C227|uniprotkb:Q8C5Q3|uniprotkb:Q8K393|uniprotkb:Q9CZY7|ensembl:ENSMUSP00000111393|ensembl:ENSMUSP00000157408	psi-mi:dmxaa(display_short)|psi-mi:"CHEBI:75934"(display_long)	psi-mi:sting_mouse(display_long)|uniprotkb:Sting1(gene name)|psi-mi:Sting1(display_short)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:Eris(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:Mita(gene name synonym)|uniprotkb:Mpys(gene name synonym)|uniprotkb:Tmem173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Gao et al. (2013)	pubmed:23910378	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8795416|wwpdb:4lol	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001276520.1|refseq:NP_001276521.1|refseq:NP_082537.1|dip:DIP-59959N|ensembl:ENSMUSG00000024349(gene)|ensembl:ENSMUST00000115728(transcript)|ensembl:ENSMUST00000237919(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4JC5|rcsb pdb:4KBY|rcsb pdb:4KC0|rcsb pdb:4LOJ|rcsb pdb:4LOK|rcsb pdb:4LOL|rcsb pdb:4YP1|rcsb pdb:6XNN|reactome:R-MMU-1834941|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-6798695|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)	-	-	-	figure legend:Supp Table 2|3d-resolution:2.43A|3d-r-factors:Rworking = 0.18 Rfree = 0.21	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/15	2014/10/16	-	rogid:n8idTbDnMp6Sw5To/kS19oCCAF010090	intact-crc:97A65F0B2754E07C	false	-	sufficient binding region:154-340	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:75947"	uniprotkb:Q3TBT3	intact:EBI-8801022	intact:EBI-3862093|uniprotkb:A7YGY9|uniprotkb:Q3TAV5|uniprotkb:Q3TYP5|uniprotkb:Q3TZY8|uniprotkb:Q3UJW3|uniprotkb:Q8C227|uniprotkb:Q8C5Q3|uniprotkb:Q8K393|uniprotkb:Q9CZY7|ensembl:ENSMUSP00000111393|ensembl:ENSMUSP00000157408	psi-mi:"cg(2'5')_pa(3'5')p"(display_short)|psi-mi:"CHEBI:75947"(display_long)	psi-mi:sting_mouse(display_long)|uniprotkb:Sting1(gene name)|psi-mi:Sting1(display_short)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:Eris(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:Mita(gene name synonym)|uniprotkb:Mpys(gene name synonym)|uniprotkb:Tmem173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Gao et al. (2013)	pubmed:23910378	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8795328|wwpdb:4loj	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001276520.1|refseq:NP_001276521.1|refseq:NP_082537.1|dip:DIP-59959N|ensembl:ENSMUSG00000024349(gene)|ensembl:ENSMUST00000115728(transcript)|ensembl:ENSMUST00000237919(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4JC5|rcsb pdb:4KBY|rcsb pdb:4KC0|rcsb pdb:4LOJ|rcsb pdb:4LOK|rcsb pdb:4LOL|rcsb pdb:4YP1|rcsb pdb:6XNN|reactome:R-MMU-1834941|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-6798695|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)	-	-	-	figure legend:Supp Table 2|3d-resolution:1.77A|3d-r-factors:"Rworking:  19.2%, Free R-factor: 21.2%"|causality statement:"CHEBI:75947 increases activity of Q3TBT3"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/15	2014/10/16	-	rogid:n8idTbDnMp6Sw5To/kS19oCCAF010090	intact-crc:EE215C74F4CF520F	false	-	sufficient binding region:154-340	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:71580"	uniprotkb:Q3TBT3	intact:EBI-8795293	intact:EBI-3862093|uniprotkb:A7YGY9|uniprotkb:Q3TAV5|uniprotkb:Q3TYP5|uniprotkb:Q3TZY8|uniprotkb:Q3UJW3|uniprotkb:Q8C227|uniprotkb:Q8C5Q3|uniprotkb:Q8K393|uniprotkb:Q9CZY7|ensembl:ENSMUSP00000111393|ensembl:ENSMUSP00000157408	psi-mi:c-gmp-amp(display_short)|psi-mi:"CHEBI:71580"(display_long)|intact:3',5'-cyclic GMP-AMP(synonym)|intact:cyclic GMP-AMP(synonym)|intact:"2-amino-9-[(2R,3R,3aS,7aR,9R,10R,10aS,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one"(iupac name)	psi-mi:sting_mouse(display_long)|uniprotkb:Sting1(gene name)|psi-mi:Sting1(display_short)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:Eris(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:Mita(gene name synonym)|uniprotkb:Mpys(gene name synonym)|uniprotkb:Tmem173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Gao et al. (2013)	pubmed:23910378	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8795398|wwpdb:4lok	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001276520.1|refseq:NP_001276521.1|refseq:NP_082537.1|dip:DIP-59959N|ensembl:ENSMUSG00000024349(gene)|ensembl:ENSMUST00000115728(transcript)|ensembl:ENSMUST00000237919(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4JC5|rcsb pdb:4KBY|rcsb pdb:4KC0|rcsb pdb:4LOJ|rcsb pdb:4LOK|rcsb pdb:4LOL|rcsb pdb:4YP1|rcsb pdb:6XNN|reactome:R-MMU-1834941|reactome:R-MMU-3134975|reactome:R-MMU-3249367|reactome:R-MMU-3270619|reactome:R-MMU-6798695|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)	-	inchi key:RFCBNSCSPXMEBK-INFSMZHSSA-N	-	figure legend:Supp Table 2|3d-resolution:2.07A|3d-r-factors:"Rworking:  0.18 Rfree = 0.24"|causality statement:"CHEBI:71580 increases activity of  Q3TBT3"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/15	2014/10/16	-	rogid:n8idTbDnMp6Sw5To/kS19oCCAF010090	intact-crc:FE709A9B35602629	false	-	sufficient binding region:154-340	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)