#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05067-PRO_0000000092	uniprotkb:P05067-PRO_0000000092	intact:EBI-821758	intact:EBI-821758	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0982"(electrophoretic mobility-based method)	Kang et al. (2013)	pubmed:23907583|imex:IM-21661	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8870298|imex:IM-21661-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:672|chain-seq-end:713	chain-seq-start:672|chain-seq-end:713	figure legend:Fig 4A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/28	2017/03/06	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	intact-crc:6928133911A10B08|rigid:WAdWRdDj3TM/wvRDi+c1H3UH/sU	false	-	-	4	0	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P05067-PRO_0000000092	intact:EBI-821758	intact:EBI-821758	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0982"(electrophoretic mobility-based method)	Kang et al. (2013)	pubmed:23907583|imex:IM-21661	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8870276|imex:IM-21661-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:672|chain-seq-end:713	chain-seq-start:672|chain-seq-end:713	figure legend:Fig 4A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/28	2017/03/06	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	intact-crc:BC87638BE5D12A89|rigid:WAdWRdDj3TM/wvRDi+c1H3UH/sU	false	-	-	2	0	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P05067-PRO_0000000092	intact:EBI-821758	intact:EBI-821758	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0982"(electrophoretic mobility-based method)	Kang et al. (2013)	pubmed:23907583|imex:IM-21661	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8870295|imex:IM-21661-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:672|chain-seq-end:713	chain-seq-start:672|chain-seq-end:713	figure legend:Fig 4A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/28	2017/03/06	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	intact-crc:3B2D550B1630CABA|rigid:WAdWRdDj3TM/wvRDi+c1H3UH/sU	false	-	-	3	0	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:P04156	uniprotkb:P05067-PRO_0000000093	intact:EBI-977302|ensembl:ENSP00000368752|ensembl:ENSP00000399376|ensembl:ENSP00000411599|ensembl:ENSP00000415284|uniprotkb:O60489|uniprotkb:P78446|uniprotkb:Q15216|uniprotkb:Q15221|uniprotkb:Q27H91|uniprotkb:Q8TBG0|uniprotkb:Q96E70|uniprotkb:Q9UP19|uniprotkb:Q5QPB4	intact:EBI-2431589|intact:EBI-20772365	psi-mi:prio_human(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Kang et al. (2013)	pubmed:23907583|imex:IM-21661	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8830542|imex:IM-21661-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000171867(gene)|ensembl:ENST00000379440(transcript)|ensembl:ENST00000424424(transcript)|ensembl:ENST00000430350(transcript)|ensembl:ENST00000457586(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009986"(cell surface)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098794"(postsynapse)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:0045121"(membrane raft)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR025860|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR036924|mint:P04156|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|rcsb pdb:1E1G|rcsb pdb:1E1J|rcsb pdb:1E1P|rcsb pdb:1E1S|rcsb pdb:1E1U|rcsb pdb:1E1W|rcsb pdb:1FKC|rcsb pdb:1FO7|rcsb pdb:1H0L|rcsb pdb:1HJM|rcsb pdb:1HJN|rcsb pdb:1I4M|rcsb pdb:1OEH|rcsb pdb:1OEI|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1QLX|rcsb pdb:1QLZ|rcsb pdb:1QM0|rcsb pdb:1QM1|rcsb pdb:1QM2|rcsb pdb:1QM3|rcsb pdb:2IV4|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|rcsb pdb:2IV5|rcsb pdb:2IV6|rcsb pdb:2K1D|rcsb pdb:2KUN|rcsb pdb:2LBG|rcsb pdb:2LEJ|rcsb pdb:2LFT|rcsb pdb:2LSB|rcsb pdb:2LV1|rcsb pdb:2M8T|rcsb pdb:2OL9|rcsb pdb:2W9E|rcsb pdb:3HAF|rcsb pdb:3HAK|rcsb pdb:3HEQ|rcsb pdb:3HER|rcsb pdb:3HES|rcsb pdb:3HJ5|rcsb pdb:3HJX|rcsb pdb:3MD4|rcsb pdb:3MD5|rcsb pdb:3NHC|rcsb pdb:3NHD|rcsb pdb:3NVF|rcsb pdb:4DGI|rcsb pdb:4E1H|rcsb pdb:4E1I|rcsb pdb:4KML|rcsb pdb:4N9O|rcsb pdb:5L6R|rcsb pdb:5YJ4|rcsb pdb:5YJ5|rcsb pdb:6DU9|rcsb pdb:6LNI|rcsb pdb:6PQ5|rcsb pdb:6PQA|rcsb pdb:6SUZ|rcsb pdb:6SV2|rcsb pdb:6UUR|reactome:R-HSA-419037|reactome:R-HSA-9609523|refseq:NP_000302.1|refseq:NP_001073590.1|refseq:NP_001073591.1|refseq:NP_001073592.1|refseq:NP_898902.1|refseq:NP_001258490.1|dip:DIP-29933N	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:711	figure legend:Table 1i|comment:Monomeric ab40 bound to PrPC|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/28	2014/10/16	rogid:O9dYBDKthE5DdgePny2xsDYzb989606	rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606	intact-crc:1FF9201E16658DC3|rigid:iL9gOCo01vhutdRpt0+MYS5r6AI	false	sufficient binding region:93-119,123-166	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P04156	intact:EBI-821758	intact:EBI-977302|ensembl:ENSP00000368752|ensembl:ENSP00000399376|ensembl:ENSP00000411599|ensembl:ENSP00000415284|uniprotkb:O60489|uniprotkb:P78446|uniprotkb:Q15216|uniprotkb:Q15221|uniprotkb:Q27H91|uniprotkb:Q8TBG0|uniprotkb:Q96E70|uniprotkb:Q9UP19|uniprotkb:Q5QPB4	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:prio_human(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Kang et al. (2013)	pubmed:23907583|imex:IM-21661	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8830520|imex:IM-21661-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000171867(gene)|ensembl:ENST00000379440(transcript)|ensembl:ENST00000424424(transcript)|ensembl:ENST00000430350(transcript)|ensembl:ENST00000457586(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009986"(cell surface)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098794"(postsynapse)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:0045121"(membrane raft)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR025860|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR036924|mint:P04156|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|rcsb pdb:1E1G|rcsb pdb:1E1J|rcsb pdb:1E1P|rcsb pdb:1E1S|rcsb pdb:1E1U|rcsb pdb:1E1W|rcsb pdb:1FKC|rcsb pdb:1FO7|rcsb pdb:1H0L|rcsb pdb:1HJM|rcsb pdb:1HJN|rcsb pdb:1I4M|rcsb pdb:1OEH|rcsb pdb:1OEI|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1QLX|rcsb pdb:1QLZ|rcsb pdb:1QM0|rcsb pdb:1QM1|rcsb pdb:1QM2|rcsb pdb:1QM3|rcsb pdb:2IV4|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|rcsb pdb:2IV5|rcsb pdb:2IV6|rcsb pdb:2K1D|rcsb pdb:2KUN|rcsb pdb:2LBG|rcsb pdb:2LEJ|rcsb pdb:2LFT|rcsb pdb:2LSB|rcsb pdb:2LV1|rcsb pdb:2M8T|rcsb pdb:2OL9|rcsb pdb:2W9E|rcsb pdb:3HAF|rcsb pdb:3HAK|rcsb pdb:3HEQ|rcsb pdb:3HER|rcsb pdb:3HES|rcsb pdb:3HJ5|rcsb pdb:3HJX|rcsb pdb:3MD4|rcsb pdb:3MD5|rcsb pdb:3NHC|rcsb pdb:3NHD|rcsb pdb:3NVF|rcsb pdb:4DGI|rcsb pdb:4E1H|rcsb pdb:4E1I|rcsb pdb:4KML|rcsb pdb:4N9O|rcsb pdb:5L6R|rcsb pdb:5YJ4|rcsb pdb:5YJ5|rcsb pdb:6DU9|rcsb pdb:6LNI|rcsb pdb:6PQ5|rcsb pdb:6PQA|rcsb pdb:6SUZ|rcsb pdb:6SV2|rcsb pdb:6UUR|reactome:R-HSA-419037|reactome:R-HSA-9609523|refseq:NP_000302.1|refseq:NP_001073590.1|refseq:NP_001073591.1|refseq:NP_001073592.1|refseq:NP_898902.1|refseq:NP_001258490.1|dip:DIP-29933N	-	chain-seq-start:672|chain-seq-end:713	-	figure legend:Table 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/28	2017/03/06	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:O9dYBDKthE5DdgePny2xsDYzb989606	intact-crc:7C1AB58BBC000862|rigid:yn2HcVuKyNvZfPqGYQ31Mrhb9fQ	false	-	sufficient binding region:23-39,93-119,159-175	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04156	uniprotkb:P05067-PRO_0000000092	intact:EBI-977302|ensembl:ENSP00000368752|ensembl:ENSP00000399376|ensembl:ENSP00000411599|ensembl:ENSP00000415284|uniprotkb:O60489|uniprotkb:P78446|uniprotkb:Q15216|uniprotkb:Q15221|uniprotkb:Q27H91|uniprotkb:Q8TBG0|uniprotkb:Q96E70|uniprotkb:Q9UP19|uniprotkb:Q5QPB4	intact:EBI-821758	psi-mi:prio_human(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:ASCR(gene name synonym)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRIP(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:ALTPRP(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kang et al. (2013)	pubmed:23907583|imex:IM-21661	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8830585|imex:IM-21661-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000171867(gene)|ensembl:ENST00000379440(transcript)|ensembl:ENST00000424424(transcript)|ensembl:ENST00000430350(transcript)|ensembl:ENST00000457586(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009986"(cell surface)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098794"(postsynapse)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:0045121"(membrane raft)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR025860|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR036924|mint:P04156|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|rcsb pdb:1E1G|rcsb pdb:1E1J|rcsb pdb:1E1P|rcsb pdb:1E1S|rcsb pdb:1E1U|rcsb pdb:1E1W|rcsb pdb:1FKC|rcsb pdb:1FO7|rcsb pdb:1H0L|rcsb pdb:1HJM|rcsb pdb:1HJN|rcsb pdb:1I4M|rcsb pdb:1OEH|rcsb pdb:1OEI|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1QLX|rcsb pdb:1QLZ|rcsb pdb:1QM0|rcsb pdb:1QM1|rcsb pdb:1QM2|rcsb pdb:1QM3|rcsb pdb:2IV4|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|rcsb pdb:2IV5|rcsb pdb:2IV6|rcsb pdb:2K1D|rcsb pdb:2KUN|rcsb pdb:2LBG|rcsb pdb:2LEJ|rcsb pdb:2LFT|rcsb pdb:2LSB|rcsb pdb:2LV1|rcsb pdb:2M8T|rcsb pdb:2OL9|rcsb pdb:2W9E|rcsb pdb:3HAF|rcsb pdb:3HAK|rcsb pdb:3HEQ|rcsb pdb:3HER|rcsb pdb:3HES|rcsb pdb:3HJ5|rcsb pdb:3HJX|rcsb pdb:3MD4|rcsb pdb:3MD5|rcsb pdb:3NHC|rcsb pdb:3NHD|rcsb pdb:3NVF|rcsb pdb:4DGI|rcsb pdb:4E1H|rcsb pdb:4E1I|rcsb pdb:4KML|rcsb pdb:4N9O|rcsb pdb:5L6R|rcsb pdb:5YJ4|rcsb pdb:5YJ5|rcsb pdb:6DU9|rcsb pdb:6LNI|rcsb pdb:6PQ5|rcsb pdb:6PQA|rcsb pdb:6SUZ|rcsb pdb:6SV2|rcsb pdb:6UUR|reactome:R-HSA-419037|reactome:R-HSA-9609523|refseq:NP_000302.1|refseq:NP_001073590.1|refseq:NP_001073591.1|refseq:NP_001073592.1|refseq:NP_898902.1|refseq:NP_001258490.1|dip:DIP-29933N	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713	figure legend:Fig 5|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/28	2017/03/06	rogid:O9dYBDKthE5DdgePny2xsDYzb989606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	intact-crc:3824C2EEBD973339|rigid:yn2HcVuKyNvZfPqGYQ31Mrhb9fQ	false	his tag:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)