#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q3UMR5 uniprotkb:Q3UMR5 intact:EBI-776370|uniprotkb:Q3TTK3|uniprotkb:B2RTD1|ensembl:ENSMUSP00000020312 intact:EBI-776370|uniprotkb:Q3TTK3|uniprotkb:B2RTD1|ensembl:ENSMUSP00000020312 psi-mi:mcu_mouse(display_long)|uniprotkb:Mcu(gene name)|psi-mi:Mcu(display_short) psi-mi:mcu_mouse(display_long)|uniprotkb:Mcu(gene name)|psi-mi:Mcu(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Raffaello et al. (2013) pubmed:23900286|imex:IM-21697 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8847720|imex:IM-21697-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028431.2|ensembl:ENSMUSG00000009647(gene)|ensembl:ENSMUST00000020312(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|mint:Q3UMR5|reactome:R-MMU-8949215|reactome:R-MMU-8949664 refseq:NP_001028431.2|ensembl:ENSMUSG00000009647(gene)|ensembl:ENSMUST00000020312(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|mint:Q3UMR5|reactome:R-MMU-8949215|reactome:R-MMU-8949664 - - - figure legend:f3a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/11/11 2014/10/16 rogid:OSUsGO0sfLXpbhDiusyHyf+avsU10090 rogid:OSUsGO0sfLXpbhDiusyHyf+avsU10090 intact-crc:3AABE38E1A9C4953|rigid:QW9PpumRp62TVX7uwxbv34CXB7w false ha tag:?-? green fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q3UMR5 uniprotkb:Q810S1 intact:EBI-776370|uniprotkb:Q3TTK3|uniprotkb:B2RTD1|ensembl:ENSMUSP00000020312 intact:EBI-8847756|uniprotkb:Q3U4A9|uniprotkb:Q9CSE7|uniprotkb:Q9D345|ensembl:ENSMUSP00000029624 psi-mi:mcu_mouse(display_long)|uniprotkb:Mcu(gene name)|psi-mi:Mcu(display_short) psi-mi:mcub_mouse(display_long)|uniprotkb:Mcub(gene name)|psi-mi:Mcub(display_short)|uniprotkb:Ccdc109b(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Raffaello et al. (2013) pubmed:23900286|imex:IM-21697 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8847785|imex:IM-21697-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028431.2|ensembl:ENSMUSG00000009647(gene)|ensembl:ENSMUST00000020312(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|mint:Q3UMR5|reactome:R-MMU-8949215|reactome:R-MMU-8949664 refseq:NP_001280573.1|refseq:NP_080055.2|ensembl:ENSMUSG00000027994(gene)|ensembl:ENSMUST00000029624(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|mint:Q810S1|reactome:R-MMU-8949215|reactome:R-MMU-8949664 - - - figure legend:f4a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/11/11 2014/10/16 rogid:OSUsGO0sfLXpbhDiusyHyf+avsU10090 rogid:mH3O+ao6ZIyoGrKG5ULrhuSsTpU10090 intact-crc:9B6C25E767CEF452|rigid:y0lcUQ2UnLMZb6d6CCz8gfWU2Z0 false flag tag:?-? his tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q3UMR5 uniprotkb:Q810S1 intact:EBI-776370|uniprotkb:Q3TTK3|uniprotkb:B2RTD1|ensembl:ENSMUSP00000020312 intact:EBI-8847756|uniprotkb:Q3U4A9|uniprotkb:Q9CSE7|uniprotkb:Q9D345|ensembl:ENSMUSP00000029624 psi-mi:mcu_mouse(display_long)|uniprotkb:Mcu(gene name)|psi-mi:Mcu(display_short) psi-mi:mcub_mouse(display_long)|uniprotkb:Mcub(gene name)|psi-mi:Mcub(display_short)|uniprotkb:Ccdc109b(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109B(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Raffaello et al. (2013) pubmed:23900286|imex:IM-21697 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-8847748|imex:IM-21697-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028431.2|ensembl:ENSMUSG00000009647(gene)|ensembl:ENSMUST00000020312(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|mint:Q3UMR5|reactome:R-MMU-8949215|reactome:R-MMU-8949664 refseq:NP_001280573.1|refseq:NP_080055.2|ensembl:ENSMUSG00000027994(gene)|ensembl:ENSMUST00000029624(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|mint:Q810S1|reactome:R-MMU-8949215|reactome:R-MMU-8949664 - - - figure legend:f4b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/11/11 2014/10/16 rogid:OSUsGO0sfLXpbhDiusyHyf+avsU10090 rogid:mH3O+ao6ZIyoGrKG5ULrhuSsTpU10090 intact-crc:CAAAF61BD4DC4CD1|rigid:y0lcUQ2UnLMZb6d6CCz8gfWU2Z0 false green fluorescent protein tag:?-? mcherry fluorescent protein tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q3UMR5 uniprotkb:Q810S1 intact:EBI-776370|uniprotkb:Q3TTK3|uniprotkb:B2RTD1|ensembl:ENSMUSP00000020312 intact:EBI-8847756|uniprotkb:Q3U4A9|uniprotkb:Q9CSE7|uniprotkb:Q9D345|ensembl:ENSMUSP00000029624 psi-mi:mcu_mouse(display_long)|uniprotkb:Mcu(gene name)|psi-mi:Mcu(display_short) psi-mi:mcub_mouse(display_long)|uniprotkb:Mcub(gene name)|psi-mi:Mcub(display_short)|uniprotkb:Ccdc109b(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109B(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Raffaello et al. (2013) pubmed:23900286|imex:IM-21697 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-8847768|imex:IM-21697-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028431.2|ensembl:ENSMUSG00000009647(gene)|ensembl:ENSMUST00000020312(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|mint:Q3UMR5|reactome:R-MMU-8949215|reactome:R-MMU-8949664 refseq:NP_001280573.1|refseq:NP_080055.2|ensembl:ENSMUSG00000027994(gene)|ensembl:ENSMUST00000029624(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|mint:Q810S1|reactome:R-MMU-8949215|reactome:R-MMU-8949664 - - - figure legend:f4b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/11/11 2014/10/16 rogid:OSUsGO0sfLXpbhDiusyHyf+avsU10090 rogid:mH3O+ao6ZIyoGrKG5ULrhuSsTpU10090 intact-crc:28CB5498E2B54502|rigid:y0lcUQ2UnLMZb6d6CCz8gfWU2Z0 false mcherry fluorescent protein tag:?-? green fluorescent protein tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q810S1 uniprotkb:Q810S1 intact:EBI-8847756|uniprotkb:Q3U4A9|uniprotkb:Q9CSE7|uniprotkb:Q9D345|ensembl:ENSMUSP00000029624 intact:EBI-8847756|uniprotkb:Q3U4A9|uniprotkb:Q9CSE7|uniprotkb:Q9D345|ensembl:ENSMUSP00000029624 psi-mi:mcub_mouse(display_long)|uniprotkb:Mcub(gene name)|psi-mi:Mcub(display_short)|uniprotkb:Ccdc109b(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109B(gene name synonym) psi-mi:mcub_mouse(display_long)|uniprotkb:Mcub(gene name)|psi-mi:Mcub(display_short)|uniprotkb:Ccdc109b(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109B(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Raffaello et al. (2013) pubmed:23900286|imex:IM-21697 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-8847777|imex:IM-21697-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001280573.1|refseq:NP_080055.2|ensembl:ENSMUSG00000027994(gene)|ensembl:ENSMUST00000029624(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|mint:Q810S1|reactome:R-MMU-8949215|reactome:R-MMU-8949664 refseq:NP_001280573.1|refseq:NP_080055.2|ensembl:ENSMUSG00000027994(gene)|ensembl:ENSMUST00000029624(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|mint:Q810S1|reactome:R-MMU-8949215|reactome:R-MMU-8949664 - - - figure legend:f4b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/11/11 2014/10/16 rogid:mH3O+ao6ZIyoGrKG5ULrhuSsTpU10090 rogid:mH3O+ao6ZIyoGrKG5ULrhuSsTpU10090 intact-crc:DFB8CA8F4766CDEE|rigid:VmObmpOsXzL/8bZzjCLeaJOfeRA false mcherry fluorescent protein tag:?-? green fluorescent protein tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q3UMR5 uniprotkb:Q3UMR5 intact:EBI-776370|uniprotkb:Q3TTK3|uniprotkb:B2RTD1|ensembl:ENSMUSP00000020312 intact:EBI-776370|uniprotkb:Q3TTK3|uniprotkb:B2RTD1|ensembl:ENSMUSP00000020312 psi-mi:mcu_mouse(display_long)|uniprotkb:Mcu(gene name)|psi-mi:Mcu(display_short) psi-mi:mcu_mouse(display_long)|uniprotkb:Mcu(gene name)|psi-mi:Mcu(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Raffaello et al. (2013) pubmed:23900286|imex:IM-21697 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0471"(MINT) intact:EBI-8847740|imex:IM-21697-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028431.2|ensembl:ENSMUSG00000009647(gene)|ensembl:ENSMUST00000020312(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|mint:Q3UMR5|reactome:R-MMU-8949215|reactome:R-MMU-8949664 refseq:NP_001028431.2|ensembl:ENSMUSG00000009647(gene)|ensembl:ENSMUST00000020312(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|mint:Q3UMR5|reactome:R-MMU-8949215|reactome:R-MMU-8949664 - - - figure legend:f3c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/11/11 2014/10/16 rogid:OSUsGO0sfLXpbhDiusyHyf+avsU10090 rogid:OSUsGO0sfLXpbhDiusyHyf+avsU10090 intact-crc:DD83283FB467D125|rigid:QW9PpumRp62TVX7uwxbv34CXB7w false green fluorescent protein tag:?-? mcherry fluorescent protein tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P10809 uniprotkb:Q3UMR5 intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712 intact:EBI-776370|uniprotkb:Q3TTK3|uniprotkb:B2RTD1|ensembl:ENSMUSP00000020312 psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym) psi-mi:mcu_mouse(display_long)|uniprotkb:Mcu(gene name)|psi-mi:Mcu(display_short) psi-mi:"MI:0051"(fluorescence technology) Raffaello et al. (2013) pubmed:23900286|imex:IM-21697 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8847850|imex:IM-21697-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N refseq:NP_001028431.2|ensembl:ENSMUSG00000009647(gene)|ensembl:ENSMUST00000020312(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|mint:Q3UMR5|reactome:R-MMU-8949215|reactome:R-MMU-8949664 go:"GO:0005739"(mitochondrion) - - figure legend:f1e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/11/11 2014/10/16 rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606 rogid:OSUsGO0sfLXpbhDiusyHyf+avsU10090 intact-crc:224A93BCCE072F72|rigid:Tdp79jZJqg1/vrHeDzc9E/RBPso false - flag tag:?-? - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:0707"(anti tag immunostaining) uniprotkb:P10809 uniprotkb:Q810S1 intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712 intact:EBI-8847756|uniprotkb:Q3U4A9|uniprotkb:Q9CSE7|uniprotkb:Q9D345|ensembl:ENSMUSP00000029624 psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym) psi-mi:mcub_mouse(display_long)|uniprotkb:Mcub(gene name)|psi-mi:Mcub(display_short)|uniprotkb:Ccdc109b(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109B(gene name synonym) psi-mi:"MI:0051"(fluorescence technology) Raffaello et al. (2013) pubmed:23900286|imex:IM-21697 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8847850|imex:IM-21697-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N refseq:NP_001280573.1|refseq:NP_080055.2|ensembl:ENSMUSG00000027994(gene)|ensembl:ENSMUST00000029624(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|mint:Q810S1|reactome:R-MMU-8949215|reactome:R-MMU-8949664 go:"GO:0005739"(mitochondrion) - - figure legend:f1e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/11/11 2014/10/16 rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606 rogid:mH3O+ao6ZIyoGrKG5ULrhuSsTpU10090 intact-crc:224A93BCCE072F72|rigid:Tdp79jZJqg1/vrHeDzc9E/RBPso false - his tag:?-? - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:0707"(anti tag immunostaining)