#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q80Z64 uniprotkb:P48432 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2313612 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:sox2_mouse(display_long)|uniprotkb:Sox2(gene name)|psi-mi:Sox2(display_short)|uniprotkb:Sox-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820522|imex:IM-21665-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_035573.3|mint:P48432|dip:DIP-54522N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030539"(male genitalia development)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035198"(miRNA binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046148"(pigment biosynthetic process)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048839"(inner ear development)|go:"GO:0048852"(diencephalon morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050973"(detection of mechanical stimulus involved in equilibrioception)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0070848"(response to growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|rcsb pdb:1GT0|rcsb pdb:6HT5|reactome:R-MMU-3769402|go:"GO:0035019"(somatic stem cell population maintenance) go:"GO:0005634"(nucleus) - - figure legend:f1e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2014/10/16 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:oO2sjv3/Iaj91kqGJ1L07+hhxVA10090 intact-crc:2B4D57EBF492A114|rigid:PHgvdxSe/WRGmRSfgx2B6g4mj8w false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q80Z64 uniprotkb:Q8BX22 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2312582|uniprotkb:A2AV00|uniprotkb:Q6S7E8|uniprotkb:Q6S7E9|uniprotkb:Q7TST6|ensembl:ENSMUSP00000029061 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:sall4_mouse(display_long)|uniprotkb:Sall4(gene name)|psi-mi:Sall4(display_short)|uniprotkb:Zinc finger protein SALL4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820522|imex:IM-21665-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_780512.2|refseq:NP_958797.2|refseq:NP_958798.2|dip:DIP-29926N|ensembl:ENSMUSG00000027547(gene)|ensembl:ENSMUST00000029061(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0001843"(neural tube closure)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009888"(tissue development)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021915"(neural tube development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8BX22|reactome:R-MMU-8943724 go:"GO:0005634"(nucleus) - - figure legend:f1e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2014/10/16 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:84RTcgupqeb0ypojGiwpAezUWVw10090 intact-crc:2B4D57EBF492A114|rigid:PHgvdxSe/WRGmRSfgx2B6g4mj8w false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q80Z64 uniprotkb:Q9R190 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-904134|uniprotkb:Q3TVT8|ensembl:ENSMUSP00000093959 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:mta2_mouse(display_long)|uniprotkb:Mta2(gene name)|psi-mi:Mta2(display_short)|uniprotkb:Mta1l1(gene name synonym)|uniprotkb:Metastasis-associated 1-like 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820522|imex:IM-21665-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_035972.3|dip:DIP-36630N|ensembl:ENSMUSG00000071646(gene)|ensembl:ENSMUST00000096240(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006306"(DNA methylation)|go:"GO:0006323"(DNA packaging)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016581"(NuRD complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR035170|interpro:IPR037964|interpro:IPR040138|interpro:IPR043151|mint:Q9R190|reactome:R-MMU-3214815|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724 go:"GO:0005634"(nucleus) - - figure legend:f1e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2014/10/16 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:iHG+WZKTCRwTvC7LdS7OayvcEuA10090 intact-crc:2B4D57EBF492A114|rigid:PHgvdxSe/WRGmRSfgx2B6g4mj8w false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q7TSZ8 uniprotkb:Q80Z64 intact:EBI-5691985|uniprotkb:Q80X97|uniprotkb:Q9CZ72|ensembl:ENSMUSP00000001975 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 psi-mi:nacc1_mouse(display_long)|uniprotkb:Nacc1(gene name)|psi-mi:Nacc1(display_short)|uniprotkb:Btbd14b(gene name synonym)|uniprotkb:Nac1(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein 14B(gene name synonym) psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820590|imex:IM-21665-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_080064.3|refseq:XP_006531355.1|refseq:XP_006531356.1|refseq:XP_006531357.1|dip:DIP-29930N|ensembl:ENSMUSG00000001910(gene)|ensembl:ENSMUST00000001975(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030054"(cell junction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018379|mint:Q7TSZ8 refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 go:"GO:0005634"(nucleus) - - figure legend:f1e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2014/10/16 rogid:Mp3o/oidyfj6U+OTJwTb2WP4Q3Y10090 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 intact-crc:D1D0C5A33672153E|rigid:REc9mEzB2WLH/UgLj3AXThAF+j0 false - flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q80Z64 uniprotkb:Q80U58 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-998056|uniprotkb:Q80UZ9|uniprotkb:Q91YW4|uniprotkb:Q925A0|uniprotkb:Q9ERC7|ensembl:ENSMUSP00000128292|ensembl:ENSMUSP00000131074 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:pum2_mouse(display_long)|uniprotkb:Pum2(gene name)|psi-mi:Pum2(display_short)|uniprotkb:Kiaa0235(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001153694.1|refseq:NP_001153691.1|refseq:NP_109648.2|ensembl:ENSMUSG00000020594(gene)|ensembl:ENSMUST00000163569(transcript)|ensembl:ENSMUST00000168361(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR001313(Pumilio RNA-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033133|interpro:IPR033712|mint:Q80U58|rcsb pdb:3GVO|rcsb pdb:3GVT|refseq:XP_006515340.1|refseq:XP_006515341.1|refseq:XP_006515342.1|refseq:XP_006515348.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:e/dB62qP4f9FUwRvNvr21RYQh8Y10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9WUV0 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-3870607|uniprotkb:Q3TMI6|ensembl:ENSMUSP00000030872 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:orc5_mouse(display_long)|uniprotkb:Orc5(gene name)|psi-mi:Orc5(display_short)|uniprotkb:Orc5l(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_036089.1|ensembl:ENSMUSG00000029012(gene)|ensembl:ENSMUST00000030872(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|mint:Q9WUV0|reactome:R-MMU-176187|reactome:R-MMU-68616|reactome:R-MMU-68689|reactome:R-MMU-68827|reactome:R-MMU-68867|reactome:R-MMU-68949|reactome:R-MMU-68962 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:Bm/RTSfoZoJf41XHuZa4ro+Zh4M10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:P61963 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8318793|uniprotkb:Q9DAE4|uniprotkb:Q3TMV9|uniprotkb:O15491|intact:MINT-4428227|ensembl:ENSMUSP00000058168 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:dcaf7_mouse(display_long)|uniprotkb:Dcaf7(gene name)|psi-mi:Dcaf7(display_short)|uniprotkb:Han11(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:Wdr68(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_082222.1|ensembl:ENSMUSG00000049354(gene)|ensembl:ENSMUST00000058438(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61963|reactome:R-MMU-8951664 go:"GO:0005634"(nucleus) - comment:mint figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:wDucyMrZBaqRcL25mMGhB4KXQtI10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:P25976 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-7364139|intact:MINT-4084181 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:ubf1_mouse(display_long)|uniprotkb:Ubtf(gene name)|psi-mi:Ubtf(display_short)|uniprotkb:Tcfubf(gene name synonym)|uniprotkb:Ubf1(gene name synonym)|uniprotkb:Ubf-1(gene name synonym)|uniprotkb:Upstream-binding factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 mint:P25976|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0001165"(RNA polymerase I cis-regulatory region sequence-specific DNA binding)|go:"GO:0001181"(RNA polymerase I general transcription initiation factor activity)|go:"GO:0001650"(fibrillar center)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR029215|interpro:IPR036910|rcsb pdb:1V63|rcsb pdb:1V64|rcsb pdb:1WGF|reactome:R-MMU-73728|reactome:R-MMU-73762|reactome:R-MMU-73772|reactome:R-MMU-73863|dip:DIP-29977N go:"GO:0005634"(nucleus) - comment:mint|function:UBF recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor SL1. It binds specifically to the upstream control element figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:TJRBUUHHZDYhIRdbtsijzuOSbAo10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q6P4S8 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8412459|uniprotkb:Q91Z01|uniprotkb:Q80UQ7|intact:MINT-4122126|uniprotkb:Q0KK58|intact:UNK-5883914|uniprotkb:Q9CTF7 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:int1_mouse(display_long)|uniprotkb:Ints1(gene name)|psi-mi:Ints1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_081024.3|dip:DIP-59891N|mint:Q6P4S8|go:"GO:0001832"(blastocyst growth)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016180"(snRNA processing)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032039"(integrator complex)|go:"GO:0034474"(U2 snRNA 3'-end processing)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022145|interpro:IPR038902|reactome:R-MMU-6807505 go:"GO:0005634"(nucleus) - function:"Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes"|comment:mint figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:RmXGIvIpxB28zAgSlbYu515hKJk10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:P23249 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8429153|uniprotkb:Q9DC64|intact:MINT-4102260|ensembl:ENSMUSP00000128246 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:mov10_mouse(display_long)|uniprotkb:Mov10(gene name)|psi-mi:Mov10(display_short)|uniprotkb:Gb110(gene name synonym)|uniprotkb:Moloney leukemia virus 10 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001156913.1|refseq:NP_032645.2|refseq:NP_001156912.1|refseq:XP_006501163.1|refseq:XP_006501164.1|dip:DIP-48575N|ensembl:ENSMUSG00000002227(gene)|ensembl:ENSMUST00000168015(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010526"(negative regulation of transposition, RNA-mediated)|go:"GO:0032574"(5'-3' RNA helicase activity)|go:"GO:0035194"(post-transcriptional gene silencing by RNA)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0150011"(regulation of neuron projection arborization)|interpro:IPR026122|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|mint:P23249|go:"GO:0043186"(P granule) go:"GO:0005634"(nucleus) - comment:mint|function:May be an helicase with an important function in development and/or control of cell proliferation figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:DYetyAovfa6MAvuugGR4bF/qd8c10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q99LB0 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8412568|intact:MINT-4137321|ensembl:ENSMUSP00000017443 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:tdif1_mouse(display_long)|uniprotkb:Dnttip1(gene name)|psi-mi:Dnttip1(display_short)|uniprotkb:Tdif1(gene name synonym)|uniprotkb:Terminal deoxynucleotidyltransferase-interacting factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_598524.1|ensembl:ENSMUSG00000017299(gene)|ensembl:ENSMUST00000017443(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0031491"(nucleosome binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR026064|interpro:IPR041384|mint:Q99LB0 go:"GO:0005634"(nucleus) - comment:mint|function:Shown to enhance TdT activity, in vitro figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:BweH0zY8lJIT2MSeFMIHAXKTkyk10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8VE92 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8458415|intact:MINT-4119996|ensembl:ENSMUSP00000038256|ensembl:ENSMUSP00000157500|ensembl:ENSMUSP00000157674 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:rbm4b_mouse(display_long)|uniprotkb:Rbm4b(gene name)|psi-mi:Rbm4b(display_short)|uniprotkb:Rbm30(gene name synonym)|uniprotkb:RNA-binding motif protein 4B(gene name synonym)|uniprotkb:RNA-binding protein 30(gene name synonym)|uniprotkb:RNA-binding motif protein 30(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_079993.2|refseq:XP_006531886.1|refseq:XP_006531887.1|refseq:XP_006531888.1|refseq:XP_006531889.1|ensembl:ENSMUSG00000033760(gene)|ensembl:ENSMUST00000036744(transcript)|ensembl:ENSMUST00000182821(transcript)|ensembl:ENSMUST00000235278(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034897|interpro:IPR034898|interpro:IPR035979|mint:Q8VE92 go:"GO:0005634"(nucleus) - comment:mint|function:May play a role in alternative splice site selection during pre-mRNA processing figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:2I/6T/r/1IAEeWsoONkRFmnGSpA10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8CIM8 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8387564|intact:MINT-4116412|uniprotkb:Q8C2H1|uniprotkb:Q91YV5|uniprotkb:Q9CSY4|uniprotkb:Q3TQQ4|ensembl:ENSMUSP00000026126 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:int4_mouse(display_long)|uniprotkb:Ints4(gene name)|psi-mi:Ints4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_081532.1|ensembl:ENSMUSG00000025133(gene)|ensembl:ENSMUST00000026126(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026003|mint:Q8CIM8|reactome:R-MMU-6807505 go:"GO:0005634"(nucleus) - function:"Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes"|comment:mint figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:zjMAsesy+6UAuHwaayEXRpfCjRg10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:O88291 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8338448|uniprotkb:Q3UJI3|uniprotkb:Q8K1X9|uniprotkb:Q05DP5|uniprotkb:Q3TRI9|uniprotkb:Q8BSJ5|uniprotkb:Q9CYG9|intact:MINT-4105453 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:zn326_mouse(display_long)|uniprotkb:Znf326(gene name)|psi-mi:Znf326(display_short)|uniprotkb:Zan75(gene name synonym)|uniprotkb:Zfp326(gene name synonym)|uniprotkb:Zinc finger protein 326(gene name synonym)|uniprotkb:Zinc finger protein interacting with mRNPs(gene name synonym)|uniprotkb:Zird(gene name synonym)|uniprotkb:Zinc finger protein-associated with nuclear matrix of 75 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_061229.2|mint:O88291|dip:DIP-58947N|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016363"(nuclear matrix)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR007071("A-kinase anchoring protein 95 (AKAP95)")|interpro:IPR034736 go:"GO:0005634"(nucleus) - comment:mint|function:Probable transcriptional activator which may play a role in neuronal differentiation. Able to bind DNA and activate expression in vitro figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:zN3bSkPnoWXOBXTrdNy4E+ICJ2E10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8K4P0 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8317615|uniprotkb:Q8CD02|intact:MINT-4117872|uniprotkb:Q8C7C6|ensembl:ENSMUSP00000025264 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:wdr33_mouse(display_long)|uniprotkb:Wdr33(gene name)|psi-mi:Wdr33(display_short)|uniprotkb:WD repeat-containing protein 33(gene name synonym)|uniprotkb:Wdc146(gene name synonym)|uniprotkb:WD repeat-containing protein of 146 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_083142.2|ensembl:ENSMUSG00000024400(gene)|ensembl:ENSMUST00000025264(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005581"(collagen trimer)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0006378"(mRNA polyadenylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:Q8K4P0|reactome:R-MMU-159231|reactome:R-MMU-72163|reactome:R-MMU-72187|reactome:R-MMU-73856|reactome:R-MMU-77595 go:"GO:0005634"(nucleus) - comment:mint figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:NX/bpHD8JkYfGZukrWGNeJwHXTU10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8BIH0 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8340347|uniprotkb:Q6NZP5|uniprotkb:Q6P553|uniprotkb:Q8BID9|intact:MINT-4110764|uniprotkb:Q9CSU1|ensembl:ENSMUSP00000157127 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:sp130_mouse(display_long)|uniprotkb:Sap130(gene name)|psi-mi:Sap130(display_short)|uniprotkb:130 kDa Sin3-associated polypeptide(gene name synonym)|uniprotkb:Sin3-associated polypeptide p130(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_766553.1|refseq:XP_006526014.1|refseq:XP_006526015.1|refseq:XP_006526017.1|ensembl:ENSMUSG00000024260(gene)|ensembl:ENSMUST00000235017(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0016607"(nuclear speck)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR024137|interpro:IPR031963|mint:Q8BIH0 go:"GO:0005634"(nucleus) - comment:mint|function:Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:028RGxsc3TCq1hDfGZbybH/gQtA10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:O54788 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-7365197|intact:MINT-142143|ensembl:ENSMUSP00000030893 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:dffb_mouse(display_long)|uniprotkb:Dffb(gene name)|psi-mi:Dffb(display_short)|uniprotkb:Cad(gene name synonym)|uniprotkb:DNA fragmentation factor 40 kDa subunit(gene name synonym)|uniprotkb:Caspase-activated deoxyribonuclease(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_031885.3|ensembl:ENSMUSG00000029027(gene)|ensembl:ENSMUST00000030893(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004536"(deoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006308"(DNA catabolic process)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR015311(Apoptosis, DNA fragmentation factor 40 kDa)|interpro:IPR039729|mint:O54788|rcsb pdb:1C9F|rcsb pdb:1F2R|rcsb pdb:1V0D|reactome:R-MMU-140342 go:"GO:0005634"(nucleus) - comment:mint|function:Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology|comment:homomint figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:6BiQzdEqkkJvzK4tj/xdBvpkWKY10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q61188 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:P46061 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-1033051|uniprotkb:Q60801|uniprotkb:Q6NZB5|ensembl:ENSMUSP00000057771|ensembl:ENSMUSP00000126849|ensembl:ENSMUSP00000130046 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:ragp1_mouse(display_long)|uniprotkb:Rangap1(gene name)|psi-mi:Rangap1(display_short)|uniprotkb:Fug1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001139646.1|refseq:NP_035371.4|ensembl:ENSMUSG00000022391(gene)|ensembl:ENSMUST00000052374(transcript)|ensembl:ENSMUST00000170134(transcript)|ensembl:ENSMUST00000171115(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016235"(aggresome)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR009109(Ran-GTPase activating protein 1, C-terminal)|interpro:IPR032675|interpro:IPR036720|mint:P46061|rcsb pdb:1KPS|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3108232|reactome:R-MMU-4615885|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9615933|reactome:R-MMU-9648025|dip:DIP-17024N go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:XrJlIJ7cGqaUyNGBsK1ifk0YbmU10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8BZ47 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821540|ensembl:ENSMUSP00000124089|uniprotkb:Q05DD7|uniprotkb:Q6PD47|uniprotkb:Q6ZQE3 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:zn609_mouse(display_long)|uniprotkb:Znf609(gene name)|psi-mi:Znf609(display_short)|uniprotkb:Kiaa0295(gene name synonym)|uniprotkb:Zfp609(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000040524(gene)|ensembl:ENSMUST00000159109(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000291"(regulation of myoblast proliferation)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR040010|mint:Q8BZ47|refseq:NP_766124.2 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:C3jQqT5gDbdn1+vdJ6058OX1r0Y10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8CFE3 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2337309|uniprotkb:Q3V092|uniprotkb:Q8BK28|uniprotkb:Q8CHI2|uniprotkb:K3W4P9|ensembl:ENSMUSP00000082034 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:rcor1_mouse(display_long)|uniprotkb:Rcor1(gene name)|psi-mi:Rcor1(display_short)|uniprotkb:D12Wsu95e(gene name synonym)|uniprotkb:Kiaa0071(gene name synonym)|uniprotkb:Protein CoREST(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:XP_006515823.1|dip:DIP-48899N|refseq:NP_932140.1|ensembl:ENSMUSG00000037896(gene)|ensembl:ENSMUST00000084968(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0045654"(positive regulation of megakaryocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:1990391"(DNA repair complex)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|mint:Q8CFE3|reactome:R-MMU-3214815|reactome:R-MMU-983231 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:5yFpm82AhZnBT5toA6FfcvVKS3E10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8BMQ3 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821556|ensembl:ENSMUSP00000099884|uniprotkb:H3BIU0|uniprotkb:Q6T3A4 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:bnc2_mouse(display_long)|uniprotkb:Bnc2(gene name)|psi-mi:Bnc2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 go:"GO:0046872"(metal ion binding)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060485"(mesenchyme development)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR040436|ensembl:ENSMUSG00000028487(gene)|ensembl:ENSMUST00000102820(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0043586"(tongue development)|refseq:NP_766458.3|mint:Q8BMQ3 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:2dIEtjIf/pzh2xiNfLVvzeHXjHg10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:P28574 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-1183003|ensembl:ENSMUSP00000106025|uniprotkb:B2RS19|uniprotkb:Q8C4Y1|intact:EBI-11108903 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:max_mouse(display_long)|uniprotkb:Myc-associated factor X(gene name synonym)|uniprotkb:Protein myn(gene name synonym)|uniprotkb:Myc-binding novel HLH/LZ protein(gene name synonym)|uniprotkb:Max(gene name)|psi-mi:Max(display_short)|uniprotkb:Myn(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0030425"(dendrite)|go:"GO:0032868"(response to insulin)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048678"(response to axon injury)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070888"(E-box binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR037933|mint:P28574|rcsb pdb:1A93|rcsb pdb:2A93|rcsb pdb:3U5V|reactome:R-MMU-8953750|go:"GO:0071339"(MLL1 complex)|ensembl:ENSMUSG00000059436(gene)|ensembl:ENSMUST00000110395(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|refseq:NP_001139648.1|refseq:NP_032584.2|dip:DIP-116N go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:/kXjf+gpJ5uqNX3tZ6WD+ZwtxJY10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:A2AJK6 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-6122905|uniprotkb:Q3TA86|uniprotkb:Q3TAG7|uniprotkb:Q3TBU4|uniprotkb:Q8C986|uniprotkb:Q8K244|ensembl:ENSMUSP00000043903|ensembl:ENSMUSP00000059079 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:chd7_mouse(display_long)|uniprotkb:Chd7(gene name)|psi-mi:Chd7(display_short)|uniprotkb:ATP-dependent helicase CHD7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:XP_006538067.1|refseq:NP_001264078.1|ensembl:ENSMUSG00000041235(gene)|ensembl:ENSMUST00000039267(transcript)|ensembl:ENSMUST00000051558(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003226"(right ventricular compact myocardium morphogenesis)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006364"(rRNA processing)|go:"GO:0007417"(central nervous system development)|go:"GO:0007512"(adult heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0021545"(cranial nerve development)|go:"GO:0021553"(olfactory nerve development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030540"(female genitalia development)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035904"(aorta development)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042471"(ear morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043584"(nose development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048752"(semicircular canal morphogenesis)|go:"GO:0048771"(tissue remodeling)|go:"GO:0048806"(genitalia development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050890"(cognition)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060123"(regulation of growth hormone secretion)|go:"GO:0060173"(limb development)|go:"GO:0060324"(face development)|go:"GO:0060384"(innervation)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060429"(epithelium development)|go:"GO:0062009"(secondary palate development)|go:"GO:0070615"|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000330(SNF2-related)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023780|interpro:IPR027417|interpro:IPR037259|interpro:IPR038718|mint:A2AJK6 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:xGLCgish7JPQt9t6qs7dcfThPGg10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9Z2E1 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-5716946|uniprotkb:E9QMV9|uniprotkb:Q811D9|uniprotkb:Q9Z2D9|ensembl:ENSMUSP00000073701 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:mbd2_mouse(display_long)|uniprotkb:Mbd2(gene name)|psi-mi:Mbd2(display_short)|uniprotkb:Methyl-CpG-binding protein MBD2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_034903.2|refseq:NP_001298000.1|ensembl:ENSMUSG00000024513(gene)|ensembl:ENSMUST00000074058(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042711"(maternal behavior)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0048568"(embryonic organ development)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025884|interpro:IPR032343|mint:Q9Z2E1|reactome:R-MMU-427413|reactome:R-MMU-73728 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:WxzH0gNkMXwFmBK/RWr2/RqWjXM10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q3U3F6 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821221 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:q3u3f6_mouse(display_long)|uniprotkb:Raly(gene name)|psi-mi:Raly(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 go:"GO:0003723"(RNA binding)|refseq:XP_017172120.1|interpro:IPR034502|mint:Q3U3F6|refseq:NP_001132983.1|refseq:NP_001132984.1|refseq:NP_075619.2|interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:XP_006499079.1|interpro:IPR035979 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:rWbCOEDAo031dJwGBq2J0h6yZE810090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:P08775 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2549849|ensembl:ENSMUSP00000050771|uniprotkb:Q5F298 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:rpb1_mouse(display_long)|uniprotkb:Polr2a(gene name)|psi-mi:Polr2a(display_short)|uniprotkb:Rpii215(gene name synonym)|uniprotkb:Rpo2-1(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000005198(gene)|ensembl:ENSMUST00000058470(transcript)|go:"GO:0000791"(euchromatin)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:0071453"(cellular response to oxygen levels)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR038120|interpro:IPR038593|interpro:IPR042102|mint:P08775|reactome:R-MMU-113418|reactome:R-MMU-5578749|reactome:R-MMU-674695|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-6796648|reactome:R-MMU-6803529|reactome:R-MMU-6807505|reactome:R-MMU-72086|reactome:R-MMU-72163|reactome:R-MMU-72165|reactome:R-MMU-72203|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-75955|reactome:R-MMU-76042|reactome:R-MMU-77075|reactome:R-MMU-9018519|reactome:R-MMU-112382|refseq:NP_001277997.1|dip:DIP-46369N go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:kUX/HdU6Y2VHAGjySBcOxfS08XA10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9DCT6 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-5692391|uniprotkb:Q3TFE6|uniprotkb:Q7TMP3|uniprotkb:Q9D183|ensembl:ENSMUSP00000104219 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:bap18_mouse(display_long)|uniprotkb:Bap18(gene name)|psi-mi:Bap18(display_short)|uniprotkb:BPTF-associated protein of 18 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001171072.1|refseq:NP_001171074.1|refseq:NP_001171077.1|refseq:NP_001171078.1|refseq:NP_081033.1|refseq:NP_665701.1|ensembl:ENSMUSG00000020831(gene)|ensembl:ENSMUST00000108578(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016589"(NURF complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR037931|mint:Q9DCT6 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:TMwOTqgJ/o0gKyMHcwb89IpfS5I10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8BM75 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8820779|ensembl:ENSMUSP00000151227|uniprotkb:E9Q523|uniprotkb:Q8C0E0|uniprotkb:Q8K4G8|uniprotkb:Q8K4L9|uniprotkb:Q9CU78|uniprotkb:Q9JIX4 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:ari5b_mouse(display_long)|uniprotkb:Arid5b(gene name)|psi-mi:Arid5b(display_short)|uniprotkb:Desrt(gene name synonym)|uniprotkb:Mrf2(gene name synonym)|uniprotkb:Developmentally and sexually retarded with transient immune abnormalities protein(gene name synonym)|uniprotkb:MRF1-like(gene name synonym)|uniprotkb:Modulator recognition factor protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000019947(gene)|ensembl:ENSMUST00000219238(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001822"(kidney development)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010761"(fibroblast migration)|go:"GO:0030325"(adrenal gland development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060613"(fat pad development)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR030408|interpro:IPR036431|mint:Q8BM75|reactome:R-MMU-3214842|go:"GO:0048644"(muscle organ morphogenesis)|refseq:NP_076087.2 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:m6SibbspBsoT2wMtBmXym5QGBW410090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9DBR0 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-4285802|uniprotkb:Q9R0L8|ensembl:ENSMUSP00000002699 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:akap8_mouse(display_long)|uniprotkb:Akap8(gene name)|psi-mi:Akap8(display_short)|uniprotkb:Akap95(gene name synonym)|uniprotkb:A-kinase anchor protein 95 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000024045(gene)|ensembl:ENSMUST00000002699(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001939"(female pronucleus)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033127"(regulation of histone phosphorylation)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044839"(cell cycle G2/M phase transition)|go:"GO:0045087"(innate immune response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|interpro:IPR007071("A-kinase anchoring protein 95 (AKAP95)")|interpro:IPR034736|mint:Q9DBR0|refseq:NP_062748.2 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:CboiIO6b/r8YM0jLmJbCdzg5S3U10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8CHI8 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2942504|uniprotkb:E9QKV1|uniprotkb:Q3TPY1|uniprotkb:Q5RKN8|uniprotkb:Q80TC8|uniprotkb:Q8BXI5|uniprotkb:Q8BYW3|uniprotkb:Q8C0P6|uniprotkb:Q8CHI7|uniprotkb:Q8VDF4|uniprotkb:Q9DA54 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:ep400_mouse(display_long)|uniprotkb:Ep400(gene name)|psi-mi:Ep400(display_short)|uniprotkb:Kiaa1498(gene name synonym)|uniprotkb:Domino homolog(gene name synonym)|uniprotkb:p400 kDa SWI2/SNF2-related protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 go:"GO:0000812"(Swr1 complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016607"(nuclear speck)|go:"GO:0016787"(hydrolase activity)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0070615"|go:"GO:1990405"(protein antigen binding)|interpro:IPR000330(SNF2-related)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR027417|interpro:IPR031575|interpro:IPR038718|reactome:R-MMU-2559584|reactome:R-MMU-2559586|refseq:NP_083613.2|refseq:NP_775089.1|refseq:XP_006535339.1|dip:DIP-61766N|mint:Q8CHI8 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:vJHZG85phcSbMEgw8LlsZdF+52o10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q91ZW3 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-927547|uniprotkb:Q8C791|uniprotkb:Q8CA22|uniprotkb:Q8VDG1|uniprotkb:Q925M9|ensembl:ENSMUSP00000044361 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:smca5_mouse(display_long)|uniprotkb:Smarca5(gene name)|psi-mi:Smarca5(display_short)|uniprotkb:Snf2h(gene name synonym)|uniprotkb:Sucrose nonfermenting protein 2 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_444354.2|dip:DIP-36073N|ensembl:ENSMUSG00000031715(gene)|ensembl:ENSMUST00000043359(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016589"(NURF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031010"(ISWI-type complex)|go:"GO:0031213"(RSF complex)|go:"GO:0031491"(nucleosome binding)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000330(SNF2-related)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR015194(Nucleosome remodelling ATPase ISWI, HAND)|interpro:IPR015195(SLIDE)|interpro:IPR017884|interpro:IPR027417|interpro:IPR036306|interpro:IPR038718|mint:Q91ZW3|reactome:R-MMU-5250924|reactome:R-MMU-5693565|reactome:R-MMU-606279 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:+HXPfdDGqKssFXooxGP7gM+u8Oc10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9Z2E1 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-5716946|uniprotkb:E9QMV9|uniprotkb:Q811D9|uniprotkb:Q9Z2D9|ensembl:ENSMUSP00000073701 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:mbd2_mouse(display_long)|uniprotkb:Mbd2(gene name)|psi-mi:Mbd2(display_short)|uniprotkb:Methyl-CpG-binding protein MBD2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_034903.2|refseq:NP_001298000.1|ensembl:ENSMUSG00000024513(gene)|ensembl:ENSMUST00000074058(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042711"(maternal behavior)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0048568"(embryonic organ development)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025884|interpro:IPR032343|mint:Q9Z2E1|reactome:R-MMU-427413|reactome:R-MMU-73728 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:WxzH0gNkMXwFmBK/RWr2/RqWjXM10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:E9Q2I4 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8820852|ensembl:ENSMUSP00000048120|ensembl:ENSMUSP00000105923 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:e9q2i4_mouse(display_long)|uniprotkb:Mideas(gene name)|psi-mi:Mideas(display_short)|uniprotkb:C130039O16Rik(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000042507(gene)|ensembl:ENSMUST00000046266(transcript)|ensembl:ENSMUST00000110294(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016575"(histone deacetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017884|mint:E9Q2I4|refseq:NP_001156973.1|refseq:NP_001156974.1|refseq:XP_006515906.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:fNjGli3xwbERsQyTFgB0diadJNg10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9QXE7 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821270|ensembl:ENSMUSP00000085549|uniprotkb:Q8BMM0|uniprotkb:Q8BYQ4|uniprotkb:Q8C0A1 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:tbl1x_mouse(display_long)|uniprotkb:Tbl1x(gene name)|psi-mi:Tbl1x(display_short)|uniprotkb:Tbl1(gene name synonym)|uniprotkb:Transducin beta-like protein 1X(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 go:"GO:0072686"(mitotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9QXE7|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-400206|reactome:R-MMU-9029569|reactome:R-MMU-9707564|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050821"(protein stabilization)|ensembl:ENSMUSG00000025246(gene)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006508"(proteolysis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016575"(histone deacetylation)|ensembl:ENSMUST00000088217(transcript)|refseq:NP_065626.1|refseq:XP_006528002.1|dip:DIP-62055N go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:/imB4mxc3ZdNePCeuVI1tpip5YQ10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q61066 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2312665|uniprotkb:O09068|uniprotkb:O09147|ensembl:ENSMUSP00000026036 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:nr0b1_mouse(display_long)|uniprotkb:Nr0b1(gene name)|psi-mi:Nr0b1(display_short)|uniprotkb:Ahch(gene name synonym)|uniprotkb:Dax1(gene name synonym)|uniprotkb:Nuclear receptor DAX-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_031456.1|dip:DIP-29929N|ensembl:ENSMUSG00000025056(gene)|ensembl:ENSMUST00000026036(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007530"(sex determination)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008406"(gonad development)|go:"GO:0008584"(male gonad development)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0032448"(DNA hairpin binding)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050682"(AF-2 domain binding)|go:"GO:0060008"(Sertoli cell differentiation)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR025900|interpro:IPR033544|interpro:IPR035500|mint:Q61066|rcsb pdb:3F5C|reactome:R-MMU-383280 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:I9visL2LIOpphOt23lKwCwCtulA10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q3V3W4 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-3043994|ensembl:ENSMUSP00000097655|ensembl:ENSMUSP00000097656 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:q3v3w4_mouse(display_long)|uniprotkb:Zbtb2(gene name)|psi-mi:Zbtb2(display_short)|uniprotkb:Gm1103(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000075327(gene)|ensembl:ENSMUST00000100077(transcript)|mint:Q3V3W4|ensembl:ENSMUST00000100078(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|refseq:NP_001028638.2|refseq:XP_006512519.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:cYgGEd5kMwCxyQy1YtFmBnxisYQ10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9CYA6 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-5738935|uniprotkb:Q3TK71|uniprotkb:Q8CCB7|uniprotkb:Q91WQ1|ensembl:ENSMUSP00000031376|ensembl:ENSMUSP00000142363 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:zchc8_mouse(display_long)|uniprotkb:Zcchc8(gene name)|psi-mi:Zcchc8(display_short)|uniprotkb:TRAMP-like complex RNA-binding factor ZCCHC8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_081770.3|ensembl:ENSMUSG00000029427(gene)|ensembl:ENSMUST00000031376(transcript)|ensembl:ENSMUST00000196282(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0031499"(TRAMP complex)|go:"GO:0034470"(ncRNA processing)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR006568(PSP, proline-rich)|mint:Q9CYA6 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:wDsSWQ3jCutZRCk3H7jQnasAkyk10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:O88559 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-3990176|uniprotkb:Q3U491|uniprotkb:Q8CI72|uniprotkb:Q91UZ7|ensembl:ENSMUSP00000058149|ensembl:ENSMUSP00000078306|ensembl:ENSMUSP00000109128|ensembl:ENSMUSP00000109132 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:men1_mouse(display_long)|uniprotkb:Men1(gene name)|psi-mi:Men1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001161960.1|refseq:NP_001161961.1|refseq:NP_001161962.1|refseq:NP_032609.1|ensembl:ENSMUSG00000024947(gene)|ensembl:ENSMUST00000056391(transcript)|ensembl:ENSMUST00000079327(transcript)|ensembl:ENSMUST00000113500(transcript)|ensembl:ENSMUST00000113504(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0009411"(response to UV)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016571"(histone methylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032925"(regulation of activin receptor signaling pathway)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007747(Menin)|mint:O88559|reactome:R-MMU-201722|reactome:R-MMU-2173796|reactome:R-MMU-381426|reactome:R-MMU-5626467|reactome:R-MMU-8957275|go:"GO:0001503"(ossification)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002076"(osteoblast development)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0008285"(negative regulation of cell population proliferation) go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:XflQwna8SxGNwRbj2qPKLJpQ1Y010090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q99NA9 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-1216589|ensembl:ENSMUSP00000026032 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:pcgf6_mouse(display_long)|uniprotkb:Pcgf6(gene name)|psi-mi:Pcgf6(display_short)|uniprotkb:Mblr(gene name synonym)|uniprotkb:Rnf134(gene name synonym)|uniprotkb:RING finger protein 134(gene name synonym)|uniprotkb:Mel18 and Bmi1-like RING finger(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_081930.1|ensembl:ENSMUSG00000025050(gene)|ensembl:ENSMUST00000026032(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR029071|interpro:IPR038037|mint:Q99NA9|reactome:R-MMU-8953750 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:mtN76GhIM+Ql+PBTvr6d5SU3VUw10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q61666 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2657552|uniprotkb:O08845|uniprotkb:Q3TFY0|uniprotkb:Q3UX35|uniprotkb:Q62365|uniprotkb:Q7TMW4|ensembl:ENSMUSP00000004222 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:hira_mouse(display_long)|uniprotkb:Hira(gene name)|psi-mi:Hira(display_short)|uniprotkb:Tuple1(gene name synonym)|uniprotkb:TUP1-like enhancer of split protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_034565.2|ensembl:ENSMUSG00000022702(gene)|ensembl:ENSMUST00000004222(transcript)|go:"GO:0000417"(HIR complex)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007369"(gastrulation)|go:"GO:0016605"(PML body)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR011494(TUP1-like enhancer of split)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031120|interpro:IPR036322|mint:Q61666|reactome:R-MMU-2559584 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:EhPH7DlphMVQhvIhJUtXRA1m+Fg10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:P59178 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-1216568|uniprotkb:Q8BHD5|ensembl:ENSMUSP00000023029 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:lmbl2_mouse(display_long)|uniprotkb:L3mbtl2(gene name)|psi-mi:L3mbtl2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_666105.2|ensembl:ENSMUSG00000022394(gene)|ensembl:ENSMUST00000023029(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006325"(chromatin organization)|go:"GO:0007398"(ectoderm development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0072089"(stem cell proliferation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR004092(Mbt repeat)|interpro:IPR012313(Zinc finger, FCS-type)|interpro:IPR038038|interpro:IPR038603|mint:P59178|reactome:R-MMU-4551638|reactome:R-MMU-8953750 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:CbvQKdGfkLDGgZ4UOMfuJImlTXM10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8BX09 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-1556543|uniprotkb:Q3TBL4|uniprotkb:Q6PAP0|uniprotkb:Q6PFC2|uniprotkb:Q3U3G1|ensembl:ENSMUSP00000141003 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:rbbp5_mouse(display_long)|uniprotkb:Rbbp5(gene name)|psi-mi:Rbbp5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_766105.2|dip:DIP-61809N|ensembl:ENSMUSG00000026439(gene)|ensembl:ENSMUST00000190997(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR037850|mint:Q8BX09|rcsb pdb:2XL2|rcsb pdb:2XL3|reactome:R-MMU-201722|reactome:R-MMU-3214841|reactome:R-MMU-8936459|reactome:R-MMU-8951664|go:"GO:0035097"(histone methyltransferase complex) go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:IfmUqzNWpYZzHDMDGeLiZqEcRK010090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:P70333 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-4282223|ensembl:ENSMUSP00000050838|ensembl:ENSMUSP00000074483|ensembl:ENSMUSP00000108827|ensembl:ENSMUSP00000108828|ensembl:ENSMUSP00000108829|uniprotkb:Q3THV9 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:hnrh2_mouse(display_long)|uniprotkb:Hnrnph2(gene name)|psi-mi:Hnrnph2(display_short)|uniprotkb:Hnrph2(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein H'(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001300645.1|refseq:NP_001300646.1|uniprotkb:A2BDV8(uniprot-removed-ac)|ensembl:ENSMUST00000074950(transcript)|ensembl:ENSMUST00000113202(transcript)|ensembl:ENSMUST00000113203(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P70333|reactome:R-MMU-72163|reactome:R-MMU-72203|ensembl:ENSMUST00000059297(transcript)|ensembl:ENSMUSG00000045427(gene)|ensembl:ENSMUST00000050331(transcript)|refseq:NP_063921.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:BKLnU/p+g6hd6joRgjXU+BO5i7o10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:E9PU93 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821006|ensembl:ENSMUSP00000106239|ensembl:ENSMUSP00000106240|ensembl:ENSMUSP00000132546 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:e9pu93_mouse(display_long)|uniprotkb:Ash2l(gene name)|psi-mi:Ash2l(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000031575(gene)|ensembl:ENSMUST00000110609(transcript)|ensembl:ENSMUST00000110610(transcript)|ensembl:ENSMUST00000166078(transcript)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR037353|mint:E9PU93|refseq:NP_001273136.1|refseq:NP_001074262.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:etoQIkZwCdbGDl4czMp51OKrSRU10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8CFI7 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2549877|ensembl:ENSMUSP00000031167 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:rpb2_mouse(display_long)|uniprotkb:Polr2b(gene name)|psi-mi:Polr2b(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit B(gene name synonym)|uniprotkb:RNA polymerase II subunit B2(gene name synonym)|uniprotkb:RNA polymerase II subunit 2(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II 140 kDa polypeptide(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000029250(gene)|ensembl:ENSMUST00000031167(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0032549"(ribonucleoside binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007120(DNA-directed RNA polymerase, subunit 2, domain 6)|interpro:IPR007121(RNA polymerase, beta subunit, conserved site)|interpro:IPR007641(RNA polymerase Rpb2, domain 7)|interpro:IPR007642(RNA polymerase Rpb2, domain 2)|interpro:IPR007644(RNA polymerase, beta subunit, protrusion)|interpro:IPR007645(RNA polymerase Rpb2, domain 3)|interpro:IPR007646(RNA polymerase Rpb2, domain 4)|interpro:IPR007647(RNA polymerase Rpb2, domain 5)|interpro:IPR014724(RNA polymerase Rpb2, OB-fold)|interpro:IPR015712(DNA-directed RNA polymerase, subunit 2)|interpro:IPR037033|interpro:IPR037034|mint:Q8CFI7|reactome:R-MMU-112382|reactome:R-MMU-113418|reactome:R-MMU-5578749|reactome:R-MMU-674695|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-6796648|reactome:R-MMU-6803529|reactome:R-MMU-6807505|reactome:R-MMU-72086|reactome:R-MMU-72163|reactome:R-MMU-72165|reactome:R-MMU-72203|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-75955|reactome:R-MMU-76042|reactome:R-MMU-77075|reactome:R-MMU-9018519|refseq:NP_722493.2|dip:DIP-57023N go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:Tmvj+m8fdVI+HHVma1Y0WYCSl4c10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q61191 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-3043883|uniprotkb:B1AUX1|ensembl:ENSMUSP00000033761|uniprotkb:Q684R1|uniprotkb:Q7TSB0|uniprotkb:Q8C2D0|uniprotkb:Q9QWH2 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:hcfc1_mouse(display_long)|uniprotkb:Hcfc1(gene name)|psi-mi:Hcfc1(display_short)|uniprotkb:C1 factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR036116|interpro:IPR037854|interpro:IPR043536|mint:Q61191|rcsb pdb:2M26|reactome:R-MMU-3214847|reactome:R-MMU-5689603|go:"GO:0071339"(MLL1 complex)|ensembl:ENSMUSG00000031386(gene)|ensembl:ENSMUST00000033761(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019046"(release from viral latency)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0062023"(collagen-containing extracellular matrix)|refseq:NP_032250.2 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:n384heBMbqHvDwzykCqgley6uUo10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q62481 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2942880|ensembl:ENSMUSP00000009102|uniprotkb:Q3U2N4|uniprotkb:Q810A9|uniprotkb:Q99K81 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:vps72_mouse(display_long)|uniprotkb:Vps72(gene name)|psi-mi:Vps72(display_short)|uniprotkb:Tcfl1(gene name synonym)|uniprotkb:Yl1(gene name synonym)|uniprotkb:Protein YL-1(gene name synonym)|uniprotkb:Transcription factor-like 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000008958(gene)|ensembl:ENSMUST00000009102(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016607"(nuclear speck)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042393"(histone binding)|go:"GO:0043486"(histone exchange)|interpro:IPR008895(YL1 nuclear)|interpro:IPR013272(YL1 nuclear, C-terminal)|mint:Q62481|refseq:NP_033362.2 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:1rx0cS7+bEX0W3qn5XVo3sSkMME10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q60737 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-771698|uniprotkb:Q8R0X4|ensembl:ENSMUSP00000096829 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:csk21_mouse(display_long)|uniprotkb:Csnk2a1(gene name)|psi-mi:Csnk2a1(display_short)|uniprotkb:Ckiia(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_031814.2|refseq:XP_011237574.1|refseq:XP_006498720.1|dip:DIP-32409N|ensembl:ENSMUSG00000074698(gene)|ensembl:ENSMUST00000099224(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0033574"(response to testosterone)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097421"(liver regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q60737|reactome:R-MMU-1483191|reactome:R-MMU-201688|reactome:R-MMU-2514853|reactome:R-MMU-445144|reactome:R-MMU-6804756|reactome:R-MMU-6814122|reactome:R-MMU-8934903|reactome:R-MMU-8939243|reactome:R-MMU-8948751 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:7UK+lLG3t/3xJi7CaiGSCIcxfPg10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q99LI5 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2312719|uniprotkb:Q3U063|uniprotkb:Q4FK52|ensembl:ENSMUSP00000039003|ensembl:ENSMUSP00000107677 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:zn281_mouse(display_long)|uniprotkb:Znf281(gene name)|psi-mi:Znf281(display_short)|uniprotkb:Zfp281(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001153723.1|refseq:NP_808311.1|dip:DIP-29927N|ensembl:ENSMUSG00000041483(gene)|ensembl:ENSMUST00000047734(transcript)|ensembl:ENSMUST00000112046(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q99LI5 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:UX8iqhzIg2wktQ6TTjRVftIXybE10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9WTJ4 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-645044|uniprotkb:Q91W14|uniprotkb:Q9CTG3|ensembl:ENSMUSP00000076603|ensembl:ENSMUSP00000126765|ensembl:ENSMUSP00000128105|ensembl:ENSMUSP00000147011|ensembl:ENSMUSP00000147082 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:fiz1_mouse(display_long)|uniprotkb:Fiz1(gene name)|psi-mi:Fiz1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001103798.1|refseq:NP_001103799.1|refseq:NP_001103800.1|refseq:NP_035943.3|refseq:XP_006539970.1|ensembl:ENSMUSG00000061374(gene)|ensembl:ENSMUST00000077385(transcript)|ensembl:ENSMUST00000165320(transcript)|ensembl:ENSMUST00000167804(transcript)|ensembl:ENSMUST00000207030(transcript)|ensembl:ENSMUST00000208944(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9WTJ4 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:XAqWkgbiR7Xk5/XuE+Ss0Gkxz5Q10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9CR11 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2942848|ensembl:ENSMUSP00000020382|uniprotkb:Q9CW86 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:yets4_mouse(display_long)|uniprotkb:Yeats4(gene name)|psi-mi:Yeats4(display_short)|uniprotkb:Gas41(gene name synonym)|uniprotkb:Glioma-amplified sequence 41 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000020171(gene)|ensembl:ENSMUST00000020382(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0140030"(modification-dependent protein binding)|interpro:IPR005033(YEATS)|interpro:IPR038704|reactome:R-MMU-8866907|mint:Q9CR11|refseq:NP_080846.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:3sPJk3794VOlE+Rf8ozOOpycQ7010090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:A2AQ25 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821027|ensembl:ENSMUSP00000066170|uniprotkb:A2AUE9|uniprotkb:A2AUF0|uniprotkb:A2AUF1|uniprotkb:Q75UV8|uniprotkb:Q75UV9|uniprotkb:Q80VK2|uniprotkb:Q8BHX8|uniprotkb:Q8BHY1|uniprotkb:Q8CHA8|uniprotkb:Q8R0K6 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:skt_mouse(display_long)|uniprotkb:Skt(gene name)|psi-mi:Skt(display_short)|uniprotkb:Etl4(gene name synonym)|uniprotkb:Kiaa1217(gene name synonym)|uniprotkb:Enhancer trap locus 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 interpro:IPR022782|interpro:IPR026725|mint:A2AQ25|ensembl:ENSMUSG00000036617(gene)|ensembl:ENSMUST00000066509(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0048706"(embryonic skeletal system development)|refseq:NP_001074475.1|refseq:NP_001171101.2|refseq:NP_084171.2|refseq:NP_835160.2|refseq:XP_006497478.1|refseq:XP_006497487.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:WI45C2F/GFoa1PhVnBHPtxCj5mM10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q7TSZ8 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-5691985|uniprotkb:Q80X97|uniprotkb:Q9CZ72|ensembl:ENSMUSP00000001975 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:nacc1_mouse(display_long)|uniprotkb:Nacc1(gene name)|psi-mi:Nacc1(display_short)|uniprotkb:Btbd14b(gene name synonym)|uniprotkb:Nac1(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein 14B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_080064.3|refseq:XP_006531355.1|refseq:XP_006531356.1|refseq:XP_006531357.1|dip:DIP-29930N|ensembl:ENSMUSG00000001910(gene)|ensembl:ENSMUST00000001975(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030054"(cell junction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018379|mint:Q7TSZ8 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:Mp3o/oidyfj6U+OTJwTb2WP4Q3Y10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8BHJ5 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-1216384|uniprotkb:Q3UWL6|uniprotkb:Q8CBG4|uniprotkb:Q8VEG3|uniprotkb:Q9EQD4|ensembl:ENSMUSP00000067164|ensembl:ENSMUSP00000141363|ensembl:ENSMUSP00000142184|ensembl:ENSMUSP00000144436 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:tbl1r_mouse(display_long)|uniprotkb:Tbl1xr1(gene name)|psi-mi:Tbl1xr1(display_short)|uniprotkb:Ira1(gene name synonym)|uniprotkb:Tblr1(gene name synonym)|uniprotkb:Transducin beta-like 1X-related protein 1(gene name synonym)|uniprotkb:Nuclear receptor corepressor/HDAC3 complex subunit TBLR1(gene name synonym)|uniprotkb:TBL1-related protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_109657.2|refseq:XP_011248020.1|refseq:XP_011248023.1|refseq:XP_011248021.1|refseq:XP_006535642.1|refseq:XP_006535643.1|refseq:XP_017175306.1|dip:DIP-38606N|ensembl:ENSMUSG00000027630(gene)|ensembl:ENSMUST00000063988(transcript)|ensembl:ENSMUST00000192328(transcript)|ensembl:ENSMUST00000193734(transcript)|ensembl:ENSMUST00000202747(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0002021"(response to dietary excess)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042393"(histone binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060613"(fat pad development)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q8BHJ5|rcsb pdb:5NAF|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-400206|reactome:R-MMU-9029569|reactome:R-MMU-9707564 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:yq19+P14lXTgaMDi8JXFd5B2dic10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9D1M0 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-4285415|uniprotkb:Q99M12|uniprotkb:Q9D712|ensembl:ENSMUSP00000032440 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:sec13_mouse(display_long)|uniprotkb:Sec13(gene name)|psi-mi:Sec13(display_short)|uniprotkb:Sec13l1(gene name synonym)|uniprotkb:SEC13-like protein 1(gene name synonym)|uniprotkb:SEC13-related protein(gene name synonym)|uniprotkb:GATOR complex protein SEC13(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_077168.2|ensembl:ENSMUSG00000030298(gene)|ensembl:ENSMUST00000032440(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032527"(protein exit from endoplasmic reticulum)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051028"(mRNA transport)|go:"GO:0061700"(GATOR2 complex)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0090114"(COPII-coated vesicle budding)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR037363|interpro:IPR037596|mint:Q9D1M0|reactome:R-MMU-141444|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-170822|reactome:R-MMU-191859|reactome:R-MMU-204005|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3108214|reactome:R-MMU-3232142|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-5578749|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9615933|reactome:R-MMU-9639288|reactome:R-MMU-9648025|reactome:R-MMU-983170|interpro:IPR036322 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:40KHYuvc/jVIxhLJTKivv2NRm7I10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8BP71 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821142|ensembl:ENSMUSP00000130739|uniprotkb:Q0R5Z7|uniprotkb:Q0R5Z8|uniprotkb:Q0VH84|uniprotkb:Q537D4|uniprotkb:Q537D5|uniprotkb:Q8BRG0|uniprotkb:Q8R2T5|uniprotkb:Q8VI62|uniprotkb:Q923W8 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:rfox2_mouse(display_long)|uniprotkb:Rbfox2(gene name)|psi-mi:Rbfox2(display_short)|uniprotkb:Fox2(gene name synonym)|uniprotkb:Fxh(gene name synonym)|uniprotkb:Hrnbp2(gene name synonym)|uniprotkb:Rbm9(gene name synonym)|uniprotkb:Fox-1 homolog B(gene name synonym)|uniprotkb:Fox-1 homolog Fxh(gene name synonym)|uniprotkb:Hexaribonucleotide-binding protein 2(gene name synonym)|uniprotkb:RNA-binding motif protein 9(gene name synonym)|uniprotkb:RNA-binding protein 9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001273346.1|refseq:NP_001273347.1|refseq:NP_001273348.1|ensembl:ENSMUSG00000033565(gene)|ensembl:ENSMUST00000171751(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0007399"(nervous system development)|go:"GO:0008380"(RNA splicing)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017325(RNA-binding protein 9/Ataxin-2-binding protein)|interpro:IPR025670|interpro:IPR034237|interpro:IPR035979|mint:Q8BP71|reactome:R-MMU-6803529|refseq:NP_001104297.1|refseq:NP_001104298.1|refseq:NP_001104299.1|refseq:NP_001104300.1|refseq:NP_444334.3|refseq:NP_780596.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:HRi3RnK49EYIZ7cCYmfqcmsudow10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q6P5G3 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8820711|uniprotkb:Q6P3F0|uniprotkb:Q8VE12|ensembl:ENSMUSP00000103485|ensembl:ENSMUSP00000103486 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:mbtd1_mouse(display_long)|uniprotkb:Mbtd1(gene name)|psi-mi:Mbtd1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_598773.2|ensembl:ENSMUSG00000059474(gene)|ensembl:ENSMUST00000107853(transcript)|ensembl:ENSMUST00000107854(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006325"(chromatin organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048706"(embryonic skeletal system development)|interpro:IPR004092(Mbt repeat)|interpro:IPR012313(Zinc finger, FCS-type)|mint:Q6P5G3|interpro:IPR038603|refseq:XP_017169693.1|refseq:XP_017169694.1|refseq:NP_001333454.1|refseq:XP_006531973.1|refseq:XP_017169695.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:3a8352D3K21q8TQTid2sB+l1zGQ10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9Z148 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-444966|uniprotkb:Q6PE08|uniprotkb:Q8K4R6|uniprotkb:Q8K4R7|uniprotkb:Q9Z149|uniprotkb:A2CG75|ensembl:ENSMUSP00000013931 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:ehmt2_mouse(display_long)|uniprotkb:Histone H3-K9 methyltransferase 3(gene name synonym)|uniprotkb:Euchromatic histone-lysine N-methyltransferase 2(gene name synonym)|uniprotkb:HLA-B-associated transcript 8(gene name synonym)|uniprotkb:Protein G9a(gene name synonym)|uniprotkb:Ehmt2(gene name)|psi-mi:Ehmt2(display_short)|uniprotkb:G9a(gene name synonym)|uniprotkb:Ng36(gene name synonym)|uniprotkb:Bat8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_665829.1|refseq:NP_671493.1|refseq:NP_001273502.1|refseq:NP_001273504.1|ensembl:ENSMUSG00000013787(gene)|ensembl:ENSMUST00000013931(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006306"(DNA methylation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007281"(germ cell development)|go:"GO:0007286"(spermatid development)|go:"GO:0007616"(long-term memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009566"(fertilization)|go:"GO:0010424"(DNA methylation on cytosine within a CG sequence)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0035265"(organ growth)|go:"GO:0035690"|go:"GO:0036166"(phenotypic switching)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048665"(neuron fate specification)|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0060992"(response to fungicide)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001214(SET)|interpro:IPR002110(Ankyrin)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR020683|interpro:IPR036770|interpro:IPR038034|interpro:IPR043550|mint:Q9Z148|reactome:R-MMU-2559582|reactome:R-MMU-3214841|reactome:R-MMU-6804760|reactome:R-MMU-73762|reactome:R-MMU-8953750|dip:DIP-31916N go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:SN94zTs0cmZHuzgtVLjSTDtfOAM10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:E9QLG3 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821123|ensembl:ENSMUSP00000106401 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:e9qlg3_mouse(display_long)|uniprotkb:Mga(gene name)|psi-mi:Mga(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000033943(gene)|ensembl:ENSMUST00000110774(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|mint:E9QLG3|refseq:NP_038748.2 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:yv4FdXEbyhC+78JIvHMzI9zVjdw10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q61191 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-3043883|uniprotkb:B1AUX1|ensembl:ENSMUSP00000033761|uniprotkb:Q684R1|uniprotkb:Q7TSB0|uniprotkb:Q8C2D0|uniprotkb:Q9QWH2 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:hcfc1_mouse(display_long)|uniprotkb:Hcfc1(gene name)|psi-mi:Hcfc1(display_short)|uniprotkb:C1 factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR036116|interpro:IPR037854|interpro:IPR043536|mint:Q61191|rcsb pdb:2M26|reactome:R-MMU-3214847|reactome:R-MMU-5689603|go:"GO:0071339"(MLL1 complex)|ensembl:ENSMUSG00000031386(gene)|ensembl:ENSMUST00000033761(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019046"(release from viral latency)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0062023"(collagen-containing extracellular matrix)|refseq:NP_032250.2 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:n384heBMbqHvDwzykCqgley6uUo10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q6IQX8 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-3044006|ensembl:ENSMUSP00000068184|ensembl:ENSMUSP00000126854|ensembl:ENSMUSP00000154709|uniprotkb:Q921W9|uniprotkb:Q924S6|uniprotkb:Q9CVF3|intact:EBI-3508329 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:zn219_mouse(display_long)|uniprotkb:Znf219(gene name)|psi-mi:Znf219(display_short)|uniprotkb:Zfp219(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000049295(gene)|ensembl:ENSMUST00000067549(transcript)|ensembl:ENSMUST00000166169(transcript)|ensembl:ENSMUST00000226522(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0060174"(limb bud formation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q6IQX8|refseq:XP_011243478.1|refseq:XP_011243479.1|refseq:XP_017171669.1|refseq:NP_081524.2|refseq:NP_001240623.1|refseq:NP_001240624.1|refseq:XP_006519561.1|refseq:XP_006519562.1|refseq:XP_006519564.1|refseq:XP_006519565.1|refseq:XP_006519566.1|refseq:XP_006519567.1|refseq:XP_006519568.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:Q6ebFbVDwgd46TS1dBOEk3kNYO410090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q80XS2 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821331 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:q80xs2_mouse(display_long)|uniprotkb:Patz1(gene name)|psi-mi:Patz1(display_short)|uniprotkb:Zfp278(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR000637(HMG-I and HMG-Y, DNA-binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|refseq:NP_001240619.1|refseq:NP_001240620.1|mint:Q80XS2|interpro:IPR036236 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:opsYid6raQXHvzRIaLzKvW0eG2810090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:E9Q2U6 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821202|ensembl:ENSMUSP00000127463 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:e9q2u6_mouse(display_long)|uniprotkb:Csnk1a1(gene name)|psi-mi:Csnk1a1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000024576(gene)|ensembl:ENSMUST00000167187(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:E9Q2U6|refseq:XP_006526450.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:4NJtX0tA4hev0tNbyoe9F4D90pA10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q62383 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-1373250|uniprotkb:Q5SYM0|uniprotkb:Q6GQS3|uniprotkb:Q6ZQI0|uniprotkb:Q8BQY6|ensembl:ENSMUSP00000002121 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:spt6h_mouse(display_long)|uniprotkb:Supt6h(gene name)|psi-mi:Supt6h(display_short)|uniprotkb:Kiaa0162(gene name synonym)|uniprotkb:Supt6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_033323.2|ensembl:ENSMUSG00000002052(gene)|ensembl:ENSMUST00000002121(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003677"(DNA binding)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008380"(RNA splicing)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034728"(nucleosome organization)|go:"GO:0035327"|go:"GO:0042393"(histone binding)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0051028"(mRNA transport)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0070827"(obsolete chromatin maintenance)|interpro:IPR000980(SH2 motif)|interpro:IPR003029(S1, RNA binding)|interpro:IPR006641(Resolvase, RNase H-like fold)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR017072(Transcription elongation factor Spt6)|interpro:IPR022967|interpro:IPR023319|interpro:IPR023323|interpro:IPR028083|interpro:IPR028088|interpro:IPR028231|interpro:IPR032706|interpro:IPR035018|interpro:IPR035019|interpro:IPR035420|interpro:IPR036860|interpro:IPR037027|interpro:IPR041692|interpro:IPR042066|mint:Q62383|reactome:R-MMU-112382|reactome:R-MMU-674695|reactome:R-MMU-75955 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:h9yOnI51aroUlQNPlgQzPlOquJs10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q6P5E3 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821083|ensembl:ENSMUSP00000034090 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:q6p5e3_mouse(display_long)|uniprotkb:Sall1(gene name)|psi-mi:Sall1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000031665(gene)|ensembl:ENSMUST00000034090(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008406"(gonad development)|go:"GO:0010369"(chromocenter)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030325"(adrenal gland development)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0061034"(olfactory bulb mitral cell layer development)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q6P5E3|go:"GO:0005737"(cytoplasm)|refseq:NP_067365.2|refseq:XP_006531301.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:0AvtVnZqI5jfuprPHy/9HTBj5Vs10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:P97929 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-1034100|uniprotkb:O35922|uniprotkb:P97383|uniprotkb:F8VPU5|ensembl:ENSMUSP00000038576|ensembl:ENSMUSP00000144150 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:brca2_mouse(display_long)|uniprotkb:Brca2(gene name)|psi-mi:Brca2(display_short)|uniprotkb:Fancd1(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001074470.1|refseq:NP_033895.2|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P97929|rcsb pdb:1MIU|rcsb pdb:1MJE|reactome:R-MMU-5685942|reactome:R-MMU-5693568|reactome:R-MMU-5693579|reactome:R-MMU-5693616|ensembl:ENSMUSG00000041147(gene)|ensembl:ENSMUST00000044620(transcript)|ensembl:ENSMUST00000202313(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008585"(female gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0031619"(homologous chromosome orientation involved in meiotic metaphase I plate congression)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0030879"(mammary gland development)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051276"(chromosome organization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|refseq:XP_017176117.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:fmZUELceuRYpVNcAMCFkhDf1zw810090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:P23198 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-78162|uniprotkb:Q921C4 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:cbx3_mouse(display_long)|uniprotkb:Cbx3(gene name)|psi-mi:Cbx3(display_short)|uniprotkb:Heterochromatin protein 1 homolog gamma(gene name synonym)|uniprotkb:Modifier 2 protein(gene name synonym)|uniprotkb:M32(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0006325"(chromatin organization)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010369"(chromocenter)|go:"GO:0019899"(enzyme binding)|go:"GO:0035985"(senescence-associated heterochromatin focus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0090734"(site of DNA damage)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|interpro:IPR038033|reactome:R-MMU-73772|reactome:R-MMU-8953750|dip:DIP-28136N|mint:P23198 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:mD/Ut3JqLl3k0Ut98GxlstErEGs10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q6PDQ2 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-3043852|ensembl:ENSMUSP00000060054 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:chd4_mouse(display_long)|uniprotkb:Chd4(gene name)|psi-mi:Chd4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000063870(gene)|ensembl:ENSMUST00000056889(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0016581"(NuRD complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0070615"|go:"GO:0072553"(terminal button organization)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000330(SNF2-related)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR009462(Protein of unknown function DUF1086)|interpro:IPR009463(Protein of unknown function DUF1087)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR012957(CHD, C-terminal 2)|interpro:IPR012958(CHD, N-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR019786|interpro:IPR019787|interpro:IPR023780|interpro:IPR027417|interpro:IPR038718|mint:Q6PDQ2|reactome:R-MMU-3214815|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-9031628|reactome:R-MMU-6804758|refseq:NP_666091.1|refseq:NP_001333539.1|dip:DIP-59651N go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:1ExHO4XVxVn9siWz99wuNhrnZMg10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q80U78 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-3647774|uniprotkb:Q80X96|uniprotkb:Q80YU8|uniprotkb:Q8BPV7|uniprotkb:Q9EPU6|ensembl:ENSMUSP00000030315 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:pum1_mouse(display_long)|uniprotkb:Pum1(gene name)|psi-mi:Pum1(display_short)|uniprotkb:Kiaa0099(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001153075.1|refseq:NP_001153076.1|refseq:NP_109647.2|ensembl:ENSMUSG00000028580(gene)|ensembl:ENSMUST00000030315(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR001313(Pumilio RNA-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033133|interpro:IPR033712|mint:Q80U78|reactome:R-MMU-432722 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:XzxF7jlRqQ2EKPGD1KAcShCdIIk10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8BRH4 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-4292563|uniprotkb:Q5YLV9|uniprotkb:Q8BK12|uniprotkb:Q8C6M3|uniprotkb:Q923H5|uniprotkb:Q923H6 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:kmt2c_mouse(display_long)|uniprotkb:Kmt2c(gene name)|psi-mi:Kmt2c(display_short)|uniprotkb:Mll3(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 mint:Q8BRH4|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0097692"(histone H3-K4 monomethylation)|interpro:IPR000637(HMG-I and HMG-Y, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036910|interpro:IPR037877|interpro:IPR041967|interpro:IPR041968|reactome:R-MMU-3214841|reactome:R-MMU-8936459|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007338"(single fertilization)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042393"(histone binding)|dip:DIP-61282N go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:t98kF/uJQH6BVGbZJcOLWEbwDHI10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q60520 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-349034|uniprotkb:Q60820|uniprotkb:Q62139|uniprotkb:Q62140|uniprotkb:Q7TPU8|uniprotkb:Q7TSZ2|ensembl:ENSMUSP00000045044|ensembl:ENSMUSP00000126601|ensembl:ENSMUSP00000130641|uniprotkb:Q570Z7 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:sin3a_mouse(display_long)|uniprotkb:Sin3a(gene name)|psi-mi:Sin3a(display_short)|uniprotkb:Kiaa4126(gene name synonym)|uniprotkb:Transcriptional corepressor Sin3a(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3a(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001103820.1|refseq:NP_001103821.1|refseq:NP_035508.2|ensembl:ENSMUSG00000042557(gene)|ensembl:ENSMUST00000049169(transcript)|ensembl:ENSMUST00000167715(transcript)|ensembl:ENSMUST00000168678(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|rcsb pdb:2RMS|reactome:R-MMU-3899300|reactome:R-MMU-400206|reactome:R-MMU-8936459|reactome:R-MMU-9022692|reactome:R-MMU-9707564|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006260"(DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007568"(aging)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031937"(obsolete positive regulation of chromatin silencing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0051595"(response to methylglyoxal)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901675"(negative regulation of histone H3-K27 acetylation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR037969|interpro:IPR039774|mint:Q60520|rcsb pdb:1G1E|rcsb pdb:1S5Q|rcsb pdb:1S5R|rcsb pdb:2L9S|rcsb pdb:2LD7|rcsb pdb:2N2H|rcsb pdb:2RMR|refseq:XP_011240985.1|refseq:XP_011240986.1|refseq:XP_011240987.1|refseq:XP_011240988.1|refseq:XP_017168720.1|refseq:XP_006510953.1|refseq:XP_006510954.1|refseq:XP_006510955.1|refseq:XP_006510956.1|dip:DIP-469N go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:xd+Wh6NZxejENeiSl5WRDOrVDtc10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9D1P2 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2552981|ensembl:ENSMUSP00000033070|uniprotkb:Q3UIY0|uniprotkb:Q8BJ69|uniprotkb:Q8BJ76|uniprotkb:Q8CI73 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:kat8_mouse(display_long)|uniprotkb:Kat8(gene name)|psi-mi:Kat8(display_short)|uniprotkb:Mof(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1(gene name synonym)|uniprotkb:Myst1(gene name synonym)|uniprotkb:Lysine acetyltransferase 8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000030801(gene)|ensembl:ENSMUST00000033070(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000776"(kinetochore)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042393"(histone binding)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043995"("histone acetyltransferase activity (H4-K5 specific)")|go:"GO:0043996"("histone acetyltransferase activity (H4-K8 specific)")|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046972"("histone acetyltransferase activity (H4-K16 specific)")|go:"GO:0071339"(MLL1 complex)|go:"GO:0072487"(MSL complex)|interpro:IPR000953(Chromo domain)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR036388|interpro:IPR037906|interpro:IPR040706|mint:Q9D1P2|rcsb pdb:1WGS|reactome:R-MMU-3214847|go:"GO:0043984"(histone H4-K16 acetylation)|refseq:NP_080646.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:eToZ6W49cdX6kqRnDjtpLELCHHA10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q5DW34 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-1216557|uniprotkb:A2AIS3|uniprotkb:A2AIS4|uniprotkb:Q6PGM0|uniprotkb:Q5EBR1|ensembl:ENSMUSP00000119057 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:ehmt1_mouse(display_long)|uniprotkb:Ehmt1(gene name)|psi-mi:Ehmt1(display_short)|uniprotkb:Euhmtase1(gene name synonym)|uniprotkb:Glp(gene name synonym)|uniprotkb:Kmt1d(gene name synonym)|uniprotkb:Euchromatic histone-lysine N-methyltransferase 1(gene name synonym)|uniprotkb:G9a-like protein 1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 1D(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001012536.2|refseq:NP_001103156.1|refseq:NP_001103157.1|dip:DIP-49000N|dip:DIP-59572N|ensembl:ENSMUSG00000036893(gene)|ensembl:ENSMUST00000147147(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0016604"(nuclear body)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018026"(peptidyl-lysine monomethylation)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0060992"(response to fungicide)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR001214(SET)|interpro:IPR002110(Ankyrin)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR020683|interpro:IPR036770|interpro:IPR038035|interpro:IPR043550|reactome:R-MMU-2559582|reactome:R-MMU-3214841|reactome:R-MMU-6804760|reactome:R-MMU-8953750|mint:Q5DW34 go:"GO:0005634"(nucleus) - caution:This sequence has been withdrawn from Uniprot. figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:hUGLAr8PFLD6Tzs7WbDQJs//I1k10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q62521 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-308132|uniprotkb:Q3UYV1|ensembl:ENSMUSP00000085999|uniprotkb:A2AWK3|uniprotkb:Q8BSB3 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:zic3_mouse(display_long)|uniprotkb:Zic3(gene name)|psi-mi:Zic3(display_short)|uniprotkb:Zinc finger protein of the cerebellum 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_033601.2|ensembl:ENSMUSG00000067860(gene)|ensembl:ENSMUST00000088627(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007389"(pattern specification process)|go:"GO:0007417"(central nervous system development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0035469"(determination of pancreatic left/right asymmetry)|go:"GO:0035545"(determination of left/right asymmetry in nervous system)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0071907"(determination of digestive tract left/right asymmetry)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041643|mint:Q62521 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:ooPtJpjY1temgbD2pSXjFvKoI3410090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:B1AWL2 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-5710090|intact:EBI-16734028|uniprotkb:A2SW42|ensembl:ENSMUSP00000095677 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:zn462_mouse(display_long)|uniprotkb:Znf462(gene name)|psi-mi:Znf462(display_short)|uniprotkb:Zfp462(gene name synonym)|uniprotkb:Zinc finger PBX1-interacting protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_766455.2|ensembl:ENSMUSG00000060206(gene)|ensembl:ENSMUST00000098070(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006325"(chromatin organization)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:B1AWL2 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:afh6qNp5fP7ayVIT0G49FBhTgNo10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q99N20 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821356|ensembl:ENSMUSP00000112266 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:brms1_mouse(display_long)|uniprotkb:Brms1(gene name)|psi-mi:Brms1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000080268(gene)|ensembl:ENSMUST00000116567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0009987"(cellular process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0070822"(Sin3-type complex)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR013907(Sds3-like)|mint:Q99N20|reactome:R-MMU-3214815|refseq:NP_598916.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:kvE0JlxbxO1xlmVN4YFCbRpbCzc10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:F8WHY8 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-6120213|ensembl:ENSMUSP00000064338|ensembl:ENSMUSP00000105348 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:f8why8_mouse(display_long)|uniprotkb:Mta1(gene name)|psi-mi:Mta1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_473422.2|ensembl:ENSMUSG00000021144(gene)|ensembl:ENSMUST00000069690(transcript)|ensembl:ENSMUST00000109726(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR035170|interpro:IPR040138|interpro:IPR043151|mint:F8WHY8 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:bSJVhbyNmLEmXNhRG9rkgV0Wj+s10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q76MZ3 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-400413|ensembl:ENSMUSP00000007708 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:2aaa_mouse(display_long)|uniprotkb:Ppp2r1a(gene name)|psi-mi:Ppp2r1a(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_058587.1|go:"GO:0051306"(mitotic sister chromatid separation)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903538"(regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1990405"(protein antigen binding)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:Q76MZ3|rcsb pdb:2IAE|rcsb pdb:2PF4|rcsb pdb:3FGA|rcsb pdb:6EF4|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-2995383|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-8854518|reactome:R-MMU-9648025|reactome:R-MMU-975957|ensembl:ENSMUSG00000007564(gene)|ensembl:ENSMUST00000007708(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051232"(meiotic spindle elongation)|dip:DIP-29429N go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:0tnO11U1SNOOT46j23f7dim8O8k10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:O88532 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-645485|uniprotkb:Q3TY30|uniprotkb:Q8BS85|uniprotkb:Q8CGG5|uniprotkb:Q91VZ0|uniprotkb:Q9CT34|ensembl:ENSMUSP00000118911 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:zfr_mouse(display_long)|uniprotkb:Zfr(gene name)|psi-mi:Zfr(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_035897.2|ensembl:ENSMUSG00000022201(gene)|ensembl:ENSMUST00000122941(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR006561(DZF)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043519|mint:O88532 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:ncNwFUEUk0r2XotuXm/9Tt4iB5w10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9CQJ4 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-927321|uniprotkb:O35699|uniprotkb:O35729|uniprotkb:Q4FJV5|uniprotkb:Q8C1X8|ensembl:ENSMUSP00000075476|ensembl:ENSMUSP00000140896 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:ring2_mouse(display_long)|uniprotkb:Rnf2(gene name)|psi-mi:Rnf2(display_short)|uniprotkb:DinG(gene name synonym)|uniprotkb:Ring1b(gene name synonym)|uniprotkb:RING finger protein 2(gene name synonym)|uniprotkb:RING finger protein 1B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RING2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_035407.1|dip:DIP-36109N|ensembl:ENSMUSG00000026484(gene)|ensembl:ENSMUST00000076110(transcript)|ensembl:ENSMUST00000187048(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071535"(RING-like zinc finger domain binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|interpro:IPR037937|interpro:IPR043540|mint:Q9CQJ4|rcsb pdb:2CKL|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:xyEv6lhWHdmO1fLEas7lRd3wbco10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:P63037 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-772408|uniprotkb:P54102|ensembl:ENSMUSP00000030118|ensembl:ENSMUSP00000129730 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:dnja1_mouse(display_long)|uniprotkb:Heat shock 40 kDa protein 4(gene name synonym)|uniprotkb:DnaJ protein homolog 2(gene name synonym)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:Dnaja1(gene name)|psi-mi:Dnaja1(display_short)|uniprotkb:Dnaj2(gene name synonym)|uniprotkb:Hsj2(gene name synonym)|uniprotkb:Hspf4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001158143.1|refseq:NP_001158144.1|refseq:NP_032324.1|dip:DIP-32350N|ensembl:ENSMUSG00000028410(gene)|ensembl:ENSMUST00000030118(transcript)|ensembl:ENSMUST00000164233(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009408"(response to heat)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:1901998"(toxin transport)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:P63037|reactome:R-MMU-3371497 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:gi42F7LF6CiylXZF4fRg/kuM/s010090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:O08550 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8820672|ensembl:ENSMUSP00000103789|uniprotkb:E9QKF4|uniprotkb:Q5NU09 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:kmt2b_mouse(display_long)|uniprotkb:Kmt2b(gene name)|psi-mi:Kmt2b(display_short)|uniprotkb:Mll2(gene name synonym)|uniprotkb:Trx2(gene name synonym)|uniprotkb:Wbp7(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog(gene name synonym)|uniprotkb:Trithorax homolog 2(gene name synonym)|uniprotkb:WW domain-binding protein 7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_083550.2|ensembl:ENSMUSG00000006307(gene)|ensembl:ENSMUST00000108154(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0005634"(nucleus)|go:"GO:0007613"(memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009994"(oocyte differentiation)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0030728"(ovulation)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|interpro:IPR001214(SET)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR041959|mint:O08550|reactome:R-MMU-3214841|reactome:R-MMU-8936459 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:Dh/RF9WCnCri0MsF/8QlIlbU25g10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q91VR5 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-773164|uniprotkb:Q3TU41|ensembl:ENSMUSP00000065987 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:ddx1_mouse(display_long)|uniprotkb:DEAD box protein 1(gene name synonym)|uniprotkb:Ddx1(gene name)|psi-mi:Ddx1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_598801.1|ensembl:ENSMUSG00000037149(gene)|ensembl:ENSMUST00000071103(transcript)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0006397"(mRNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071920"(cleavage body)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR043136|mint:Q91VR5 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:NXUFdXIf8H/od5xV+OXhcO+51aY10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q99J62 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-1180260|ensembl:ENSMUSP00000023598 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:rfc4_mouse(display_long)|uniprotkb:Activator 1 subunit 4(gene name synonym)|uniprotkb:Rfc4(gene name)|psi-mi:Rfc4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_663455.1|ensembl:ENSMUSG00000022881(gene)|ensembl:ENSMUST00000023598(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005663"(DNA replication factor C complex)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0019899"(enzyme binding)|go:"GO:0031390"(Ctf18 RFC-like complex)|go:"GO:0031391"(Elg1 RFC-like complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR013748(Replication factor C)|interpro:IPR027417|mint:Q99J62|reactome:R-MMU-110312|reactome:R-MMU-110314|reactome:R-MMU-110320|reactome:R-MMU-174411|reactome:R-MMU-176187|reactome:R-MMU-5651801|reactome:R-MMU-5655862|reactome:R-MMU-5656121|reactome:R-MMU-5656169|reactome:R-MMU-5685938|reactome:R-MMU-5685942|reactome:R-MMU-5693607|reactome:R-MMU-5693616|reactome:R-MMU-5696397|reactome:R-MMU-5696400|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-6804756|reactome:R-MMU-69091|reactome:R-MMU-69473 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:/b4330329gTjg/4g79oGZvdIFQc10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8BFQ4 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-6260783|ensembl:ENSMUSP00000020490|uniprotkb:Q8VEE8|uniprotkb:Q8K2G5 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:wdr82_mouse(display_long)|uniprotkb:Cdw5(gene name synonym)|uniprotkb:Wdr82(gene name)|psi-mi:Wdr82(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000020257(gene)|ensembl:ENSMUST00000020490(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|interpro:IPR037867|mint:Q8BFQ4|refseq:NP_084172.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:0TyKYwpTLd22Cm+ihT1+n0oo12c10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:P52293 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-3043908|ensembl:ENSMUSP00000018506|ensembl:ENSMUSP00000137310|uniprotkb:Q64292 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:ima1_mouse(display_long)|uniprotkb:Kpna2(gene name)|psi-mi:Kpna2(display_short)|uniprotkb:Rch1(gene name synonym)|uniprotkb:Importin alpha P1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-2(gene name synonym)|uniprotkb:Pendulin(gene name synonym)|uniprotkb:Pore targeting complex 58 kDa subunit(gene name synonym)|uniprotkb:RAG cohort protein 1(gene name synonym)|uniprotkb:SRP1-alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000018362(gene)|ensembl:ENSMUSG00000066878(gene)|ensembl:ENSMUST00000018506(transcript)|ensembl:ENSMUST00000086423(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043657"(host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52293|rcsb pdb:1EJL|rcsb pdb:1EJY|rcsb pdb:1IAL|rcsb pdb:1IQ1|rcsb pdb:1PJM|rcsb pdb:1PJN|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1Y2A|rcsb pdb:2C1M|rcsb pdb:2YNR|rcsb pdb:3BTR|rcsb pdb:3KND|rcsb pdb:3L3Q|rcsb pdb:3OQS|rcsb pdb:3Q5U|rcsb pdb:3RZ9|rcsb pdb:3RZX|rcsb pdb:3TPM|rcsb pdb:3TPO|rcsb pdb:3UKW|rcsb pdb:3UKX|rcsb pdb:3UKZ|rcsb pdb:3UL0|rcsb pdb:3UL1|rcsb pdb:3UVU|rcsb pdb:3VE6|rcsb pdb:3ZIN|rcsb pdb:3ZIO|rcsb pdb:3ZIP|rcsb pdb:3ZIQ|rcsb pdb:3ZIR|rcsb pdb:4BA3|rcsb pdb:4HTV|rcsb pdb:4MZ5|rcsb pdb:4MZ6|rcsb pdb:4OIH|rcsb pdb:4U54|rcsb pdb:4U58|rcsb pdb:4U5L|rcsb pdb:4U5N|rcsb pdb:4U5O|rcsb pdb:4U5S|rcsb pdb:4U5U|rcsb pdb:4U5V|rcsb pdb:4UAF|rcsb pdb:4YI0|rcsb pdb:4ZDU|rcsb pdb:5B56|rcsb pdb:5CTT|rcsb pdb:5D5K|rcsb pdb:5E6Q|rcsb pdb:5EKF|rcsb pdb:5EKG|rcsb pdb:5FC8|rcsb pdb:5GXW|rcsb pdb:3UKY|rcsb pdb:5HHG|rcsb pdb:5HUW|rcsb pdb:5HUY|rcsb pdb:5K9S|rcsb pdb:5KLR|rcsb pdb:5SVZ|rcsb pdb:5U5P|rcsb pdb:5U5R|rcsb pdb:5UMZ|rcsb pdb:5V5O|rcsb pdb:5V5P|rcsb pdb:5W41|rcsb pdb:5W4E|rcsb pdb:5W4F|rcsb pdb:5W4G|rcsb pdb:5WUM|rcsb pdb:5WUN|rcsb pdb:5X8N|rcsb pdb:6BVT|rcsb pdb:6BW0|rcsb pdb:6BW1|rcsb pdb:6D7M|rcsb pdb:6D7N|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:5KLT|rcsb pdb:6IW8|rcsb pdb:6IWA|rcsb pdb:6K06|rcsb pdb:6MJL|rcsb pdb:6P6A|rcsb pdb:6P6E|rcsb pdb:6WX7|rcsb pdb:7JJM|rcsb pdb:7JK7|rcsb pdb:7JVO|rcsb pdb:7L04|reactome:R-MMU-5693548|refseq:NP_034785.1|dip:DIP-47774N go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:qML5OVHqAJODiP+FSG9fTsiV3JQ10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9CW03 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2550068|ensembl:ENSMUSP00000025930|uniprotkb:O35667|uniprotkb:Q9QUS3 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:smc3_mouse(display_long)|uniprotkb:Smc3(gene name)|psi-mi:Smc3(display_short)|uniprotkb:Bam(gene name synonym)|uniprotkb:Bmh(gene name synonym)|uniprotkb:Cspg6(gene name synonym)|uniprotkb:Mmip1(gene name synonym)|uniprotkb:Smc3l1(gene name synonym)|uniprotkb:Smcd(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan 6(gene name synonym)|uniprotkb:Chromosome segregation protein SmcD(gene name synonym)|uniprotkb:Basement membrane-associated chondroitin proteoglycan(gene name synonym)|uniprotkb:Mad member-interacting protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000024974(gene)|ensembl:ENSMUST00000025930(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000800"(lateral element)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041741|mint:Q9CW03|rcsb pdb:2WD5|reactome:R-MMU-2467813|reactome:R-MMU-2468052|reactome:R-MMU-2470946|reactome:R-MMU-2500257|reactome:R-MMU-3108214|refseq:NP_031816.2|dip:DIP-57028N go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:9tJqVTJ2k3viYrJVtDfH2TekFIg10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q62255 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-3043962|uniprotkb:Q08EB0|uniprotkb:Q52KR5|uniprotkb:Q6GQT8|uniprotkb:Q8BRD9 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:sall3_mouse(display_long)|uniprotkb:Sall3(gene name)|psi-mi:Sall3(display_short)|uniprotkb:Sal(gene name synonym)|uniprotkb:MSal(gene name synonym)|uniprotkb:Spalt-like protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0021891"(olfactory bulb interneuron development)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046872"(metal ion binding)|refseq:NP_840064.2|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|mint:Q62255|interpro:IPR036236 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:vXrmUg8gZgQAtfHxHzVtqrZL/QQ10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q60I23 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-6120118|ensembl:ENSMUSP00000096755 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:q60i23_mouse(display_long)|uniprotkb:Sox2(gene name)|psi-mi:Sox2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_035573.3|ensembl:ENSMUSG00000074637(gene)|ensembl:ENSMUST00000099151(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009611"(response to wounding)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070848"(response to growth factor)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|mint:Q60I23 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:wrjO9bW/1FSRTFU3393hUYE1oeI10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9WUD1 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-773027|uniprotkb:Q9DCJ0|ensembl:ENSMUSP00000040431 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:chip_mouse(display_long)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:Stub1(gene name)|psi-mi:Stub1(display_short)|uniprotkb:Chip(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_062693.1|dip:DIP-29751N|ensembl:ENSMUSG00000039615(gene)|ensembl:ENSMUST00000044911(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006457"(protein folding)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9WUD1|rcsb pdb:2C2L|rcsb pdb:2C2V|rcsb pdb:3Q47|rcsb pdb:3Q49|rcsb pdb:3Q4A|reactome:R-MMU-2173788|reactome:R-MMU-5675482|reactome:R-MMU-8863795|reactome:R-MMU-8939902|reactome:R-MMU-8948751|reactome:R-MMU-983168 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:C5WR6X2IRpYeSijSpib3cquUaBQ10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:D6RCK1 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8820988|ensembl:ENSMUSP00000119101 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:d6rck1_mouse(display_long)|uniprotkb:Rad51(gene name)|psi-mi:Rad51(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000027323(gene)|ensembl:ENSMUST00000152327(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|interpro:IPR010995(DNA repair Rad51/transcription factor NusA, alpha-helical)|interpro:IPR013632(Rad51, C-terminal)|interpro:IPR020588|interpro:IPR027417|interpro:IPR033925|mint:D6RCK1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:BNqJHFi6FeNvQLWsLRgwJQmxJ8010090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:D3YTR4 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8820969|ensembl:ENSMUSP00000100985 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:d3ytr4_mouse(display_long)|uniprotkb:Mbd3(gene name)|psi-mi:Mbd3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000035478(gene)|ensembl:ENSMUST00000105348(transcript)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0016581"(NuRD complex)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025884|interpro:IPR032343|interpro:IPR037965|refseq:XP_006513366.1|mint:D3YTR4 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:zHbJg+3kTEKdnpc1fikGnigyVhU10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8C796 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-3043949|ensembl:ENSMUSP00000063335|uniprotkb:Q9JMK4 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:rcor2_mouse(display_long)|uniprotkb:Rcor2(gene name)|psi-mi:Rcor2(display_short)|uniprotkb:M-CoREST(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000024968(gene)|ensembl:ENSMUST00000066646(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|mint:Q8C796|refseq:NP_001307483.1|refseq:NP_473389.2|dip:DIP-59754N go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:R+uWIOSogm6HqGyspApSgHyMh1k10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9R190 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-904134|uniprotkb:Q3TVT8|ensembl:ENSMUSP00000093959 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:mta2_mouse(display_long)|uniprotkb:Mta2(gene name)|psi-mi:Mta2(display_short)|uniprotkb:Mta1l1(gene name synonym)|uniprotkb:Metastasis-associated 1-like 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_035972.3|dip:DIP-36630N|ensembl:ENSMUSG00000071646(gene)|ensembl:ENSMUST00000096240(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006306"(DNA methylation)|go:"GO:0006323"(DNA packaging)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016581"(NuRD complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR035170|interpro:IPR037964|interpro:IPR040138|interpro:IPR043151|mint:Q9R190|reactome:R-MMU-3214815|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:iHG+WZKTCRwTvC7LdS7OayvcEuA10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q6NWW4 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8820908 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:q6nww4_mouse(display_long)|uniprotkb:Rex2(gene name)|psi-mi:Rex2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 interpro:IPR001909(Krueppel-associated box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|mint:Q6NWW4|interpro:IPR036051|interpro:IPR036236 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:iNB2qa9XlBYtLW2N3znCQs7jw1I10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9CU65 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2312762|uniprotkb:Q3UUZ8|uniprotkb:Q3UXK7|uniprotkb:Q80XP0|uniprotkb:B2RUS2|ensembl:ENSMUSP00000022511 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:zmym2_mouse(display_long)|uniprotkb:Zmym2(gene name)|psi-mi:Zmym2(display_short)|uniprotkb:Zfp198(gene name synonym)|uniprotkb:Znf198(gene name synonym)|uniprotkb:Zinc finger protein 198(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:XP_006519728.1|refseq:NP_083774.2|refseq:XP_017171710.1|dip:DIP-29928N|ensembl:ENSMUSG00000021945(gene)|ensembl:ENSMUST00000022511(transcript)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016605"(PML body)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|interpro:IPR010507(Zinc finger, MYM-type)|interpro:IPR011017(TRASH)|interpro:IPR021893|mint:Q9CU65 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:gIm0LYQWUamVGDkVsYWlgKrzePw10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:D3YZC7 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821393|ensembl:ENSMUSP00000111432 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:d3yzc7_mouse(display_long)|uniprotkb:Brd8(gene name)|psi-mi:Brd8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 mint:D3YZC7|interpro:IPR038002|ensembl:ENSMUSG00000003778(gene)|ensembl:ENSMUST00000115766(transcript)|go:"GO:0000812"(Swr1 complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|interpro:IPR001487(Bromodomain)|interpro:IPR036427|interpro:IPR037966|refseq:NP_001276536.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:SHMvECQ4KYtguWyIpBxYVsQ6YtE10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9WTX8 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-4285225|uniprotkb:Q9WTX9|ensembl:ENSMUSP00000031534 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:md1l1_mouse(display_long)|uniprotkb:Mad1l1(gene name)|psi-mi:Mad1l1(display_short)|uniprotkb:Mad1(gene name synonym)|uniprotkb:Mitotic arrest deficient 1-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_034882.2|ensembl:ENSMUSG00000029554(gene)|ensembl:ENSMUST00000031534(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043515"(kinetochore binding)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902426"(deactivation of mitotic spindle assembly checkpoint)|interpro:IPR008672(Mitotic checkpoint)|mint:Q9WTX8|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|go:"GO:0048538"(thymus development)|refseq:XP_006504714.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:uJ8x1UBlL+30Ss2DFiEhiGLoNfo10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8QZV7 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821373|ensembl:ENSMUSP00000032427|uniprotkb:E9QLV7|uniprotkb:Q99JT8 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:int13_mouse(display_long)|uniprotkb:IntS13(gene name)|psi-mi:IntS13(display_short)|uniprotkb:Asun(gene name synonym)|uniprotkb:Cell cycle regulator Mat89Bb homolog(gene name synonym)|uniprotkb:Protein asunder homolog(gene name synonym)|uniprotkb:Spata30(gene name synonym)|uniprotkb:Spermatogenesis-associated protein 30(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000040250(gene)|ensembl:ENSMUST00000032427(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0016604"(nuclear body)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0032039"(integrator complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0080154"(regulation of fertilization)|go:"GO:0090435"(protein localization to nuclear envelope)|interpro:IPR019355|mint:Q8QZV7|reactome:R-MMU-6807505|go:"GO:0005634"(nucleus)|refseq:NP_620096.2 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:/QL3zLVBUTPUiLBobLd8/f4sQTI10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:D3Z687 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8820759|ensembl:ENSMUSP00000104216 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:d3z687_mouse(display_long)|uniprotkb:0610010K14Rik(gene name)|psi-mi:0610010K14Rik(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001171072.1|ensembl:ENSMUSG00000020831(gene)|ensembl:ENSMUST00000108576(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016589"(NURF complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR037931|mint:D3Z687 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:OkBn6iM3azFt7WXFMxhHka/GVr010090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8VI33 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2943311|ensembl:ENSMUSP00000081772|ensembl:ENSMUSP00000132143|ensembl:ENSMUSP00000140244|uniprotkb:Q32P09|uniprotkb:Q80XS3|uniprotkb:Q9CV61 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:taf9_mouse(display_long)|uniprotkb:Taf9(gene name)|psi-mi:Taf9(display_short)|uniprotkb:Taf2g(gene name synonym)|uniprotkb:RNA polymerase II TBP-associated factor subunit G(gene name synonym)|uniprotkb:Transcription initiation factor TFIID 31 kDa subunit(gene name synonym)|uniprotkb:Transcription initiation factor TFIID 32 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 reactome:R-MMU-674695|ensembl:ENSMUSG00000052293(gene)|ensembl:ENSMUSG00000078941(gene)|ensembl:ENSMUST00000084721(transcript)|ensembl:ENSMUST00000167256(transcript)|ensembl:ENSMUST00000190594(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0000125"|reactome:R-MMU-6804756|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|reactome:R-MMU-6807505|reactome:R-MMU-73776|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0030914"|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0070761"(pre-snoRNP complex)|go:"GO:0071339"(MLL1 complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003162(Transcription factor TAFII-31)|interpro:IPR009072(Histone-fold)|mint:Q8VI33|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-76042|refseq:NP_001015889.1|refseq:NP_081415.1|dip:DIP-48737N go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:kcrFxMARm/ZQPZ/AnbjtARGYowA10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:P54276 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2549976|uniprotkb:Q6GTK8|ensembl:ENSMUSP00000005503|uniprotkb:O54710 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:msh6_mouse(display_long)|uniprotkb:Msh6(gene name)|psi-mi:Msh6(display_short)|uniprotkb:Gtmbp(gene name synonym)|uniprotkb:MutS-alpha 160 kDa subunit(gene name synonym)|uniprotkb:G/T mismatch-binding protein(gene name synonym)|uniprotkb:MutS protein homolog 6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000005370(gene)|ensembl:ENSMUST00000005503(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006290"(pyrimidine dimer repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019899"(enzyme binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032142"(single guanine insertion binding)|go:"GO:0032143"(single thymine insertion binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0035064"(methylated histone binding)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR000313(PWWP)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR017261(DNA mismatch repair protein Msh6)|interpro:IPR027417|interpro:IPR036187|interpro:IPR036678|mint:P54276|reactome:R-MMU-5358565|refseq:NP_034960.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:vz2JuuX9XEhk1b4qWBrLcOJpbNo10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q99LI5 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2312719|uniprotkb:Q3U063|uniprotkb:Q4FK52|ensembl:ENSMUSP00000039003|ensembl:ENSMUSP00000107677 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:zn281_mouse(display_long)|uniprotkb:Znf281(gene name)|psi-mi:Znf281(display_short)|uniprotkb:Zfp281(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001153723.1|refseq:NP_808311.1|dip:DIP-29927N|ensembl:ENSMUSG00000041483(gene)|ensembl:ENSMUST00000047734(transcript)|ensembl:ENSMUST00000112046(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q99LI5 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:UX8iqhzIg2wktQ6TTjRVftIXybE10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9WUP7 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8820873|ensembl:ENSMUSP00000140106|uniprotkb:Q9CVJ4|uniprotkb:Q9CXZ3|uniprotkb:Q9R107 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:uchl5_mouse(display_long)|uniprotkb:Uchl5(gene name)|psi-mi:Uchl5(display_short)|uniprotkb:Uch37(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000018189(gene)|ensembl:ENSMUST00000189936(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|rcsb pdb:4WLQ|rcsb pdb:4WLR|reactome:R-MMU-5689603|mint:Q9WUP7|refseq:NP_001153338.1|refseq:NP_062508.2 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:beQW0dMxUbBMmUuqIkLPRvRVNH410090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q61103 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-5691800|uniprotkb:Q3UNP5|uniprotkb:Q60663|uniprotkb:Q9QYA3|ensembl:ENSMUSP00000120125 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:requ_mouse(display_long)|uniprotkb:Dpf2(gene name)|psi-mi:Dpf2(display_short)|uniprotkb:Baf45d(gene name synonym)|uniprotkb:Req(gene name synonym)|uniprotkb:Ubid4(gene name synonym)|uniprotkb:Apoptosis response zinc finger protein(gene name synonym)|uniprotkb:BRG1-associated factor 45D(gene name synonym)|uniprotkb:D4, zinc and double PHD fingers family 2(gene name synonym)|uniprotkb:Protein requiem(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_035392.1|refseq:NP_001278007.1|dip:DIP-59247N|ensembl:ENSMUSG00000024826(gene)|ensembl:ENSMUST00000136983(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0042393"(histone binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0062072"(H3K9me3 modified histone binding)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071565"(nBAF complex)|go:"GO:1905454"(negative regulation of myeloid progenitor cell differentiation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR019787|interpro:IPR025750|interpro:IPR036236|mint:Q61103 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:1KI7KoHStxGVEX0yT6Et10s5M/810090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:O70133 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2657677|uniprotkb:O35931|uniprotkb:O54703|uniprotkb:Q5FWY1|uniprotkb:Q6R5F7|uniprotkb:Q9CSA2 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:dhx9_mouse(display_long)|uniprotkb:Dhx9(gene name)|psi-mi:Dhx9(display_short)|uniprotkb:Ddx9(gene name synonym)|uniprotkb:Nuclear DNA helicase II(gene name synonym)|uniprotkb:DEAH box protein 9(gene name synonym)|uniprotkb:RNA helicase A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_031868.2|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR007502(Helicase-associated region)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001069"(regulatory region RNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005844"(polysome)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007623"(circadian rhythm)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016442"(RISC complex)|go:"GO:0016604"(nuclear body)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033679"(3'-5' DNA/RNA helicase activity)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045142"(triplex DNA binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070269"(pyroptosis)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904973"(positive regulation of viral translation)|go:"GO:1905172"(RISC complex binding)|go:"GO:1905538"(polysome binding)|go:"GO:1905698"(positive regulation of polysome binding)|go:"GO:1990518"(single-stranded 3'-5' DNA helicase activity)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000765"(regulation of cytoplasmic translation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|rcsb pdb:1UIL|rcsb pdb:1WHQ|rcsb pdb:2RS6|rcsb pdb:2RS7|reactome:R-MMU-1810476|reactome:R-MMU-3134963|reactome:R-MMU-72163|interpro:IPR027417|mint:O70133|interpro:IPR044445|interpro:IPR044446|interpro:IPR044447 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:8NHxvbw0StglewhGm3e7Pi/8oOg10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8K5C0 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-5717152|uniprotkb:Q80UZ5|ensembl:ENSMUSP00000022895 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:grhl2_mouse(display_long)|uniprotkb:Grhl2(gene name)|psi-mi:Grhl2(display_short)|uniprotkb:Bom(gene name synonym)|uniprotkb:Tcfcp2l3(gene name synonym)|uniprotkb:Brother of mammalian grainyhead(gene name synonym)|uniprotkb:Transcription factor CP2-like 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_080772.2|ensembl:ENSMUSG00000022286(gene)|ensembl:ENSMUST00000022895(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001161"(intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007155"(cell adhesion)|go:"GO:0007420"(brain development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0021915"(neural tube development)|go:"GO:0030323"(respiratory tube development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0034329"(cell junction assembly)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045617"(negative regulation of keratinocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060324"(face development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060672"(epithelial cell morphogenesis involved in placental branching)|go:"GO:0061713"(anterior neural tube closure)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090132"(epithelium migration)|interpro:IPR007604(CP2 transcription factor)|mint:Q8K5C0 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:D5WqWH1g/7zjMeERw3qXrf5S3wc10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:P60762 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2943018|ensembl:ENSMUSP00000082346|uniprotkb:Q8BNY9|uniprotkb:Q99MQ0 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:mo4l1_mouse(display_long)|uniprotkb:Morf4l1(gene name)|psi-mi:Morf4l1(display_short)|uniprotkb:Mrg15(gene name synonym)|uniprotkb:Tex189(gene name synonym)|uniprotkb:MORF-related gene 15 protein(gene name synonym)|uniprotkb:Testis-expressed gene 189 protein(gene name synonym)|uniprotkb:Transcription factor-like protein MRG15(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000062270(gene)|ensembl:ENSMUST00000085248(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003682"(chromatin binding)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006342"|go:"GO:0008283"(cell population proliferation)|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0047485"(protein N-terminus binding)|interpro:IPR008676(MRG)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR026541|interpro:IPR038011|interpro:IPR038217|mint:P60762|refseq:NP_001034236.1|refseq:NP_077751.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:8lFFlYOrwpJaf32UFUdVWMA8cJY10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:E9Q794 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8820603|ensembl:ENSMUSP00000107968 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:e9q794_mouse(display_long)|uniprotkb:Mta3(gene name)|psi-mi:Mta3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001164524.1|ensembl:ENSMUSG00000055817(gene)|ensembl:ENSMUST00000112349(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR035170|interpro:IPR040138|interpro:IPR043151|mint:E9Q794 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:fk1u/pSr9mBPs9vH6sgY5nWtWco10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q3USB6 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821216 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:q3usb6_mouse(display_long)|uniprotkb:Emsy(gene name)|psi-mi:Emsy(display_short)|uniprotkb:2210018M11Rik(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR033482|mint:Q3USB6 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:yorN6QZDcK9jSzEK8jQVRIAOVm410090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q91WA4 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-5717260|uniprotkb:Q3V0R4|uniprotkb:Q8CES6|uniprotkb:Q8CF49|ensembl:ENSMUSP00000054307 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:cxxc5_mouse(display_long)|uniprotkb:Cxxc5(gene name)|psi-mi:Cxxc5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_598448.1|refseq:XP_006526239.1|refseq:XP_006526240.1|refseq:XP_006526241.1|refseq:XP_006526243.1|refseq:XP_006526244.1|ensembl:ENSMUSG00000046668(gene)|ensembl:ENSMUST00000060722(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR040388|mint:Q91WA4 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:cPrDVaLK1cujUdQqbAWMnphqaos10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q6ZQ88 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-1216284|ensembl:ENSMUSP00000111977|uniprotkb:Q6PB53|uniprotkb:Q8VEA1|uniprotkb:A3KG94 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:kdm1a_mouse(display_long)|uniprotkb:Kdm1a(gene name)|psi-mi:Kdm1a(display_short)|uniprotkb:Kiaa0601(gene name synonym)|uniprotkb:Lsd1(gene name synonym)|uniprotkb:Flavin-containing amine oxidase domain-containing protein 2(gene name synonym)|uniprotkb:BRAF35-HDAC complex protein BHC110(gene name synonym)|uniprotkb:Aof2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_598633.2|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032451"(demethylase activity)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032453"(histone H3-methyl-lysine-4 demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0032991"(protein-containing complex)|ensembl:ENSMUSG00000036940(gene)|ensembl:ENSMUST00000116273(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006482"(protein demethylation)|go:"GO:0008134"(transcription factor binding)|dip:DIP-38599N|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0033184"(positive regulation of histone ubiquitination)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034648"("obsolete histone demethylase activity (H3-dimethyl-K4 specific)")|go:"GO:0034649"("obsolete histone demethylase activity (H3-monomethyl-K4 specific)")|go:"GO:0034720"(histone H3-K4 demethylation)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0043426"(MRF binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045654"(positive regulation of megakaryocyte differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046098"(guanine metabolic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0055001"(muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061752"(telomeric repeat-containing RNA binding)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1903827"|go:"GO:1990138"(neuron projection extension)|go:"GO:1990391"(DNA repair complex)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR002937(Amine oxidase)|interpro:IPR007526(SWIRM)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017366(Histone lysine-specific demethylase)|interpro:IPR036188|mint:Q6ZQ88|reactome:R-MMU-3214815|reactome:R-MMU-3214842|reactome:R-MMU-5625886|reactome:R-MMU-9018519|reactome:R-MMU-983231|interpro:IPR036388 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:4rlXgUzLs3mhV2FLX207Io9etU010090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9CQJ4 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-927321|uniprotkb:O35699|uniprotkb:O35729|uniprotkb:Q4FJV5|uniprotkb:Q8C1X8|ensembl:ENSMUSP00000075476|ensembl:ENSMUSP00000140896 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:ring2_mouse(display_long)|uniprotkb:Rnf2(gene name)|psi-mi:Rnf2(display_short)|uniprotkb:DinG(gene name synonym)|uniprotkb:Ring1b(gene name synonym)|uniprotkb:RING finger protein 2(gene name synonym)|uniprotkb:RING finger protein 1B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RING2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_035407.1|dip:DIP-36109N|ensembl:ENSMUSG00000026484(gene)|ensembl:ENSMUST00000076110(transcript)|ensembl:ENSMUST00000187048(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071535"(RING-like zinc finger domain binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|interpro:IPR037937|interpro:IPR043540|mint:Q9CQJ4|rcsb pdb:2CKL|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:xyEv6lhWHdmO1fLEas7lRd3wbco10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:A2APB8 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8820625|uniprotkb:Q3U500|uniprotkb:Q6P9S6|ensembl:ENSMUSP00000028969|ensembl:ENSMUSP00000105441|ensembl:ENSMUSP00000128888|ensembl:ENSMUSP00000136457 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:tpx2_mouse(display_long)|uniprotkb:Tpx2(gene name)|psi-mi:Tpx2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001135447.1|refseq:NP_001135448.1|refseq:NP_001135449.1|refseq:NP_001135450.1|refseq:NP_082385.3|ensembl:ENSMUSG00000027469(gene)|ensembl:ENSMUST00000028969(transcript)|ensembl:ENSMUST00000109816(transcript)|ensembl:ENSMUST00000164120(transcript)|ensembl:ENSMUST00000178997(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005818"(aster)|go:"GO:0005819"(spindle)|go:"GO:0005880"(nuclear microtubule)|go:"GO:0006915"(apoptotic process)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0043203"(axon hillock)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR009675(Targeting for Xklp2)|interpro:IPR015128(Aurora-A binding)|interpro:IPR027329|interpro:IPR027330|mint:A2APB8|reactome:R-MMU-6804756|reactome:R-MMU-8854518|refseq:XP_006500276.1|refseq:XP_006500277.1|refseq:XP_006500278.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:Skpl167w+a1k0+N0RdrYJUh8pOo10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:E9QAQ7 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821249|ensembl:ENSMUSP00000122354 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:e9qaq7_mouse(display_long)|uniprotkb:Arid1a(gene name)|psi-mi:Arid1a(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000007880(gene)|ensembl:ENSMUST00000145664(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035060"(brahma complex)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021906|interpro:IPR030094|interpro:IPR033388|interpro:IPR036431|mint:E9QAQ7|refseq:XP_006539389.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:L24mbvgZYgjkne9iXSXE4d6QohM10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:A0A338P6K9 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8820921|ensembl:ENSMUSP00000155882|uniprotkb:A2BIE1|uniprotkb:Q3UR75 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:qser1_mouse(display_long)|uniprotkb:Qser1(gene name)|psi-mi:Qser1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000074994(gene)|ensembl:ENSMUST00000231375(transcript)|interpro:IPR025451|mint:A0A338P6K9|refseq:XP_006500521.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:axcsRVyLRD6mBiBbdo5c/Ooj1nU10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8BX22 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2312582|uniprotkb:A2AV00|uniprotkb:Q6S7E8|uniprotkb:Q6S7E9|uniprotkb:Q7TST6|ensembl:ENSMUSP00000029061 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:sall4_mouse(display_long)|uniprotkb:Sall4(gene name)|psi-mi:Sall4(display_short)|uniprotkb:Zinc finger protein SALL4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_780512.2|refseq:NP_958797.2|refseq:NP_958798.2|dip:DIP-29926N|ensembl:ENSMUSG00000027547(gene)|ensembl:ENSMUST00000029061(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0001843"(neural tube closure)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009888"(tissue development)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021915"(neural tube development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8BX22|reactome:R-MMU-8943724 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:84RTcgupqeb0ypojGiwpAezUWVw10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8R080 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821067|ensembl:ENSMUSP00000155552|ensembl:ENSMUSP00000128759|uniprotkb:O89015|uniprotkb:Q9CSG9 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:gtse1_mouse(display_long)|uniprotkb:Gtse1(gene name)|psi-mi:Gtse1(display_short)|uniprotkb:B99(gene name synonym)|uniprotkb:Protein B99(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUST00000170629(transcript)|ensembl:ENSMUST00000231074(transcript)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|interpro:IPR026657|interpro:IPR026659|interpro:IPR032768|mint:Q8R080|reactome:R-MMU-69481|reactome:R-MMU-8852276|ensembl:ENSMUSG00000022385(gene)|refseq:NP_001162143.1|refseq:NP_038910.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:tCQD24picQTccWM8HUB8WDc9XEg10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9JI44 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2942577|ensembl:ENSMUSP00000099748|uniprotkb:Q99LM0|uniprotkb:Q9CSS9|uniprotkb:Q9DB33 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:dmap1_mouse(display_long)|uniprotkb:Dmap1(gene name)|psi-mi:Dmap1(display_short)|uniprotkb:Mmtr(gene name synonym)|uniprotkb:MAT1-mediated transcriptional repressor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000009640(gene)|ensembl:ENSMUST00000102687(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000812"(Swr1 complex)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043486"(histone exchange)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR008468(DNA methyltransferase 1-associated 1)|interpro:IPR027109|interpro:IPR032563|mint:Q9JI44|refseq:NP_075667.1|refseq:XP_006503329.1|refseq:XP_006503330.1|refseq:XP_006503331.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:C2S3vgRhvQ9TiJXiveavi3yrTJI10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8BG32 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-992214|ensembl:ENSMUSP00000017572|ensembl:ENSMUSP00000133571 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:psd11_mouse(display_long)|uniprotkb:26S proteasome regulatory subunit S9(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p44.5(gene name synonym)|uniprotkb:Psmd11(gene name)|psi-mi:Psmd11(display_short)|uniprotkb:26S proteasome regulatory subunit RPN6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_848731.2|ensembl:ENSMUSG00000017428(gene)|ensembl:ENSMUST00000017572(transcript)|ensembl:ENSMUST00000173938(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0043248"(proteasome assembly)|interpro:IPR040773|go:"GO:0048863"(stem cell differentiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR035295|interpro:IPR036390|interpro:IPR040780|mint:Q8BG32|reactome:R-MMU-1169091|reactome:R-MMU-1234176|reactome:R-MMU-1236978|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2467813|reactome:R-MMU-2871837|reactome:R-MMU-349425|reactome:R-MMU-350562|reactome:R-MMU-382556|reactome:R-MMU-450408|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-4641258|reactome:R-MMU-5358346|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5668541|reactome:R-MMU-5676590|reactome:R-MMU-5687128|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-6798695|reactome:R-MMU-68827|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69481|reactome:R-MMU-69601|reactome:R-MMU-8852276|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939236|reactome:R-MMU-8939902|reactome:R-MMU-8941858|reactome:R-MMU-8948751|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-983168|reactome:R-MMU-75815 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:J0WRN/hjSLPvj9mR+VMFZrkHSk410090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:A2ATY4 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8820655|ensembl:ENSMUSP00000088560|ensembl:ENSMUSP00000108783 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:a2aty4_mouse(display_long)|uniprotkb:Zbtb34(gene name)|psi-mi:Zbtb34(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000068966(gene)|ensembl:ENSMUST00000091037(transcript)|ensembl:ENSMUST00000113158(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|mint:A2ATY4|interpro:IPR036236|refseq:NP_001078976.1|refseq:XP_006498103.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:Qkcq8W6mQKJ8lcwTXd+rQVLB2Do10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:F6ZBR8 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8820770|ensembl:ENSMUSP00000126253 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:f6zbr8_mouse(display_long)|uniprotkb:Wiz(gene name)|psi-mi:Wiz(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000024050(gene)|ensembl:ENSMUST00000169488(transcript)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:F6ZBR8|refseq:XP_006524128.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:w3EGl8N5T9Gqrc6cLAF0oHXnsqo10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8CHY6 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-3043877|ensembl:ENSMUSP00000112164|ensembl:ENSMUSP00000148474|uniprotkb:Q8BTQ2|uniprotkb:Q8VEC9 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:p66a_mouse(display_long)|uniprotkb:Gatad2a(gene name)|psi-mi:Gatad2a(display_short)|uniprotkb:GATA zinc finger domain-containing protein 2A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000036180(gene)|ensembl:ENSMUST00000116463(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001842"(neural fold formation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0012501"(programmed cell death)|go:"GO:0016581"(NuRD complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0021506"(anterior neuropore closure)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR032346|interpro:IPR040386|mint:Q8CHY6|reactome:R-MMU-3214815|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|ensembl:ENSMUST00000212478(transcript)|refseq:XP_011240597.1|refseq:NP_001106817.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:Sl8kjbcfcvx+CKED3wLD9HvAEjs10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:E9QKA2 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8820944|ensembl:ENSMUSP00000112103 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:e9qka2_mouse(display_long)|uniprotkb:Esrrb(gene name)|psi-mi:Esrrb(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001152972.1|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|mint:E9QKA2|ensembl:ENSMUST00000116402(transcript)|ensembl:ENSMUSG00000021255(gene) go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:OPuepM7peJw/JG7FtqYpkV0GIfM10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:E9Q9Y4 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821312|ensembl:ENSMUSP00000133279 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:e9q9y4_mouse(display_long)|uniprotkb:Tet1(gene name)|psi-mi:Tet1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000047146(gene)|ensembl:ENSMUST00000174189(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0006211"(5-methylcytosine catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0070579"(methylcytosine dioxygenase activity)|go:"GO:0080111"(DNA demethylation)|go:"GO:0090310"(negative regulation of DNA methylation-dependent heterochromatin assembly)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR024779|interpro:IPR040175|mint:E9Q9Y4|refseq:XP_011241811.1|refseq:NP_001240786.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:mA7BZRlESp2mTrFJVsmq3tKKofA10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8CCI5 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-929290|uniprotkb:Q9WVK2|uniprotkb:B2RRB6|ensembl:ENSMUSP00000098677 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:rybp_mouse(display_long)|uniprotkb:Rybp(gene name)|psi-mi:Rybp(display_short)|uniprotkb:Dedaf(gene name synonym)|uniprotkb:Death effector domain-associated factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_062717.2|ensembl:ENSMUSG00000072872(gene)|ensembl:ENSMUST00000101118(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0031519"(PcG protein complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR033774|interpro:IPR036443|interpro:IPR039958|mint:Q8CCI5|reactome:R-MMU-8939243|reactome:R-MMU-8953750 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:6BAe40LmdbvRNKWeg5yGRcHgGRY10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8CGN4 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-1216174|uniprotkb:Q6PDK5|uniprotkb:Q6ZPM3|uniprotkb:Q8BKF5|uniprotkb:Q8CGN1|uniprotkb:Q8CGN2|uniprotkb:Q8CGN3|uniprotkb:B1AXK3|uniprotkb:B1AXK4|uniprotkb:B1AXK5|uniprotkb:B1AXK6|ensembl:ENSMUSP00000111175 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:bcor_mouse(display_long)|uniprotkb:Bcor(gene name)|psi-mi:Bcor(display_short)|uniprotkb:Kiaa1575(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001161793.1|refseq:NP_083786.2|refseq:NP_778209.2|refseq:NP_778210.2|refseq:NP_778211.2|refseq:XP_017174110.1|refseq:XP_017174111.1|refseq:XP_017174112.1|refseq:XP_017174113.1|dip:DIP-29852N|ensembl:ENSMUSG00000040363(gene)|ensembl:ENSMUST00000115513(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000415"(negative regulation of histone H3-K36 methylation)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007507"(heart development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0042476"(odontogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0065001"(specification of axis polarity)|go:"GO:0070171"(negative regulation of tooth mineralization)|go:"GO:0140261"(BCOR complex)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR031628|interpro:IPR032365|interpro:IPR036770|interpro:IPR038227|mint:Q8CGN4|go:"GO:0001835"(blastocyst hatching) go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:pP+f/rncs1LPbNu+vOm1Q44oZ3w10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q7TSY8 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2552468|ensembl:ENSMUSP00000027202|uniprotkb:Q8C9C4|uniprotkb:Q811I4|uniprotkb:Q9CS55|uniprotkb:Q8CGJ4 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:sgo2_mouse(display_long)|uniprotkb:Sgo2(gene name)|psi-mi:Sgo2(display_short)|uniprotkb:Sgol2(gene name synonym)|uniprotkb:Sgol2a(gene name synonym)|uniprotkb:Shugoshin-2(gene name synonym)|uniprotkb:Shugoshin-like 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUST00000027202(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008104"(protein localization)|go:"GO:0010789"(meiotic sister chromatid cohesion involved in meiosis I)|go:"GO:0016604"(nuclear body)|go:"GO:0030892"(mitotic cohesin complex)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:2000711"(positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric)|interpro:IPR026706|interpro:IPR038889|mint:Q7TSY8|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|ensembl:ENSMUSG00000026039(gene)|refseq:NP_001171338.1|refseq:NP_950172.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:DJjoQ6spU+RxltEduZMJRaCQN6A10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:E9Q2B2 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8820822|ensembl:ENSMUSP00000098628 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:e9q2b2_mouse(display_long)|uniprotkb:Ncor1(gene name)|psi-mi:Ncor1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000018501(gene)|ensembl:ENSMUST00000101067(transcript)|go:"GO:0003677"(DNA binding)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:E9Q2B2 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:Y1oI0DdfH3wNELusM8vCuOfA9XI10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9ERU9 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-643756|uniprotkb:E9QM01|uniprotkb:Q61992|uniprotkb:Q8C9K9|ensembl:ENSMUSP00000003310 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:rbp2_mouse(display_long)|uniprotkb:Ran-binding protein 2(gene name synonym)|uniprotkb:Ranbp2(gene name)|psi-mi:Ranbp2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_035370.2|reactome:R-MMU-191859|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3108214|reactome:R-MMU-3232142|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-4615885|reactome:R-MMU-5578749|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|ensembl:ENSMUSG00000003226(gene)|ensembl:ENSMUST00000003310(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006457"(protein folding)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR022011|interpro:IPR029000|interpro:IPR036443|mint:Q9ERU9|reactome:R-MMU-141444|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-170822 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:cjIAIF0uuxSMRXErJiJc+OBJpAw10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:E9QLK7 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-5683081|ensembl:ENSMUSP00000098035 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:e9qlk7_mouse(display_long)|uniprotkb:Trrap(gene name)|psi-mi:Trrap(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001074831.1|refseq:XP_017176067.1|ensembl:ENSMUSG00000045482(gene)|ensembl:ENSMUST00000100467(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0016301"(kinase activity)|go:"GO:0016573"(histone acetylation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033317|mint:E9QLK7 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:cfay74G9mewqbnNMfMUJvCC+W8Y10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8BTW3 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-3835562|uniprotkb:Q9CSR7|ensembl:ENSMUSP00000147696 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:exos6_mouse(display_long)|uniprotkb:Exosc6(gene name)|psi-mi:Exosc6(display_short)|uniprotkb:Mtr3(gene name synonym)|uniprotkb:Exosome component 6(gene name synonym)|uniprotkb:mRNA transport regulator 3 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_082550.1|ensembl:ENSMUSG00000109941(gene)|ensembl:ENSMUST00000210390(transcript)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0034475"(U4 snRNA 3'-end processing)|go:"GO:0045006"(DNA deamination)|go:"GO:0045190"(isotype switching)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071051"(polyadenylation-dependent snoRNA 3'-end processing)|interpro:IPR001247(Exoribonuclease, phosphorolytic domain 1)|interpro:IPR020568|interpro:IPR027408|interpro:IPR036345|mint:Q8BTW3|reactome:R-MMU-429958|reactome:R-MMU-450385|reactome:R-MMU-450513|reactome:R-MMU-450604|reactome:R-MMU-6791226 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:T1m4+ZV2a+vpfBOaDD8qU5cZ85c10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:P22227 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2313372|uniprotkb:Q4KMN3|uniprotkb:Q7TPU3 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:zfp42_mouse(display_long)|uniprotkb:Zfp42(gene name)|psi-mi:Zfp42(display_short)|uniprotkb:Rex-1(gene name synonym)|uniprotkb:Rex1(gene name synonym)|uniprotkb:Reduced expression protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_033582.2|mint:P22227|dip:DIP-54911N|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0031519"(PcG protein complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:REI3nJ1n09QYCKp2R/9lgwV54EA10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:D3YUW8 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821235|ensembl:ENSMUSP00000102890 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:d3yuw8_mouse(display_long)|uniprotkb:Pogz(gene name)|psi-mi:Pogz(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000038902(gene)|ensembl:ENSMUST00000107269(transcript)|go:"GO:0003677"(DNA binding)|interpro:IPR004875(CENP-B protein)|interpro:IPR006600(Centromere protein B, helix-turn-helix)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:D3YUW8|interpro:IPR009057(Homeodomain-like) go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:TDhZJTgic9GUIsuAUjhn3IH5LPQ10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q9Z0Z7 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-647919|uniprotkb:Q9JMI2|ensembl:ENSMUSP00000005279 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:klf5_mouse(display_long)|uniprotkb:Intestinal-enriched krueppel-like factor(gene name synonym)|uniprotkb:Transcription factor BTEB2(gene name synonym)|uniprotkb:Basic transcription element-binding protein 2(gene name synonym)|uniprotkb:Klf5(gene name)|psi-mi:Klf5(display_short)|uniprotkb:Bteb2(gene name synonym)|uniprotkb:Iklf(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_033899.2|dip:DIP-49582N|ensembl:ENSMUSG00000005148(gene)|ensembl:ENSMUST00000005279(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0014901"(satellite cell activation involved in skeletal muscle regeneration)|go:"GO:0014908"(myotube differentiation involved in skeletal muscle regeneration)|go:"GO:0030033"(microvillus assembly)|go:"GO:0032534"(regulation of microvillus assembly)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043426"(MRF binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0099156"(cell-cell signaling via exosome)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000723"(negative regulation of cardiac vascular smooth muscle cell differentiation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030401|interpro:IPR036236|mint:Q9Z0Z7 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:jxgbCaFB4L8JIVdagGl2JZ/PxxQ10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q6ZQ08 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-682479|intact:EBI-2104684|uniprotkb:B2RY28|uniprotkb:Q3UPB7|uniprotkb:Q8BSB4|uniprotkb:Q8BXB2|uniprotkb:Q8C0H2|uniprotkb:Q8K3D8 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:cnot1_mouse(display_long)|uniprotkb:Cnot1(gene name)|psi-mi:Cnot1(display_short)|uniprotkb:Kiaa1007(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_835179.1|refseq:XP_006530937.1|dip:DIP-46845N|mint:Q6ZQ08|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR007196(CCR4-Not complex component, Not1)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR024557|interpro:IPR032191|interpro:IPR032193|interpro:IPR032194|interpro:IPR038535|interpro:IPR040398|reactome:R-MMU-429947|reactome:R-MMU-6804115 go:"GO:0005634"(nucleus) - comment:AfCS Y2H protein 39306. Translated from nucleotide sequence. figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:2Q4quoSuPlUbD4QkiAkc9Hr9avI10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:P15864 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-913436|ensembl:ENSMUSP00000045816 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:h12_mouse(display_long)|uniprotkb:H1-2(gene name)|psi-mi:H1-2(display_short)|uniprotkb:H1 VAR.1(gene name synonym)|uniprotkb:H1c(gene name synonym)|uniprotkb:H1f2(gene name synonym)|uniprotkb:Hist1h1c(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_056601.1|ensembl:ENSMUSG00000036181(gene)|ensembl:ENSMUST00000040914(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0035327"|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0098532"(histone H3-K27 trimethylation)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:P15864|reactome:R-MMU-140342|reactome:R-MMU-2559584|dip:DIP-35245N go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:xZTLhoQ8/vdiyHIxpxFNUWquFf810090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q8VHR5 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-3043880|ensembl:ENSMUSP00000041370|ensembl:ENSMUSP00000142514|ensembl:ENSMUSP00000142617|uniprotkb:Q8C9Q3 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:p66b_mouse(display_long)|uniprotkb:Gatad2b(gene name)|psi-mi:Gatad2b(display_short)|uniprotkb:GATA zinc finger domain-containing protein 2B(gene name synonym)|uniprotkb:p66/p68(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000042390(gene)|ensembl:ENSMUST00000049382(transcript)|ensembl:ENSMUST00000199607(transcript)|ensembl:ENSMUST00000199754(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016581"(NuRD complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR032346|interpro:IPR040386|reactome:R-MMU-3214815|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|mint:Q8VHR5|refseq:XP_006501422.2|refseq:NP_647465.1|refseq:XP_006501424.1|dip:DIP-62049N go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:u6tGN+nqNC/bn1hYG7e1f3XGgj010090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q45VK5 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821300|ensembl:ENSMUSP00000111074 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:q45vk5_mouse(display_long)|uniprotkb:Ilf3(gene name)|psi-mi:Ilf3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000032178(gene)|ensembl:ENSMUST00000115414(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0051607"(defense response to virus)|interpro:IPR006561(DZF)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR033099|interpro:IPR043519|mint:Q45VK5|refseq:NP_001036174.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:37fOo7DqctBeDKYspPrjfiIshCA10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q3UM33 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8820731|ensembl:ENSMUSP00000037981 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:q3um33_mouse(display_long)|uniprotkb:Hdac3(gene name)|psi-mi:Hdac3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_034541.2|ensembl:ENSMUSG00000024454(gene)|ensembl:ENSMUST00000043498(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072686"(mitotic spindle)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q3UM33|interpro:IPR000286(Histone deacetylase superfamily) go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:a/9o4csctay/bJbH+bvclsgA5zg10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q64028 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-927346|uniprotkb:P70359|uniprotkb:Q64307|uniprotkb:Q8BZ80 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:phc1_mouse(display_long)|uniprotkb:Phc1(gene name)|psi-mi:Phc1(display_short)|uniprotkb:Edr(gene name synonym)|uniprotkb:Edr1(gene name synonym)|uniprotkb:Rae28(gene name synonym)|uniprotkb:Early development regulatory protein 1(gene name synonym)|uniprotkb:RAE-28(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001258508.1|go:"GO:0001739"(sex chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR012313(Zinc finger, FCS-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR038603|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750|mint:Q64028|dip:DIP-456N go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:z2SieJadS53WlofBWE3/RNMYPnw10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:Q99N20 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8821356|ensembl:ENSMUSP00000112266 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:brms1_mouse(display_long)|uniprotkb:Brms1(gene name)|psi-mi:Brms1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000080268(gene)|ensembl:ENSMUST00000116567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0009987"(cellular process)|go:"GO:0016575"(histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0070822"(Sin3-type complex)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR013907(Sds3-like)|mint:Q99N20|reactome:R-MMU-3214815|refseq:NP_598916.1 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:kvE0JlxbxO1xlmVN4YFCbRpbCzc10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:E9QAT4 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-647676|uniprotkb:A2AIX1|uniprotkb:Q80U43|uniprotkb:Q811L5|intact:EBI-8820930|intact:EBI-10045685|intact:EBI-8573308|intact:MINT-8174146|ensembl:ENSMUSP00000088796 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:sc16a_mouse(display_long)|uniprotkb:Sec16a(gene name)|psi-mi:Sec16a(display_short)|uniprotkb:Kiaa0310(gene name synonym)|uniprotkb:SEC16 homolog A(gene name synonym)|uniprotkb:Sec16(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_694765.2|refseq:XP_006497974.1|ensembl:ENSMUSG00000026924(gene)|ensembl:ENSMUST00000091252(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0031090"(organelle membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043000"(Golgi to plasma membrane CFTR protein transport)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR024298|interpro:IPR024340|interpro:IPR024880|mint:E9QAT4|reactome:R-MMU-204005|go:"GO:0032527"(protein exit from endoplasmic reticulum) go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:97WhpZFikynLgEykn8l5NJODOpo10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:A2A654 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-5738095|ensembl:ENSMUSP00000102374 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:a2a654_mouse(display_long)|uniprotkb:Bptf(gene name)|psi-mi:Bptf(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000040481(gene)|ensembl:ENSMUST00000106763(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007492"(endoderm development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009611"(response to wounding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016589"(NURF complex)|go:"GO:0030425"(dendrite)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042766"(nucleosome mobilization)|go:"GO:0043005"(neuron projection)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044297"(cell body)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018359|interpro:IPR018501|interpro:IPR019786|interpro:IPR019787|interpro:IPR028941|interpro:IPR036427|interpro:IPR038028|mint:A2A654 go:"GO:0005634"(nucleus) - crc64:DB5E7A095A97E3AA figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:C63RAKZUeznzQRzzHI8k2muj1YU10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:E9Q2B2 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-8820822|ensembl:ENSMUSP00000098628 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:e9q2b2_mouse(display_long)|uniprotkb:Ncor1(gene name)|psi-mi:Ncor1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8820601|imex:IM-21665-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 ensembl:ENSMUSG00000018501(gene)|ensembl:ENSMUST00000101067(transcript)|go:"GO:0003677"(DNA binding)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:E9Q2B2 go:"GO:0005634"(nucleus) - - figure legend:t1 st1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2021/12/01 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:Y1oI0DdfH3wNELusM8vCuOfA9XI10090 intact-crc:B3ED58BF30D17C05|rigid:WvDjfU4sxaqQWM94oiKWQc+Xslw false flag tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q80Z64 uniprotkb:P48432 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2313612 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:sox2_mouse(display_long)|uniprotkb:Sox2(gene name)|psi-mi:Sox2(display_short)|uniprotkb:Sox-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8821604|imex:IM-21665-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_035573.3|mint:P48432|dip:DIP-54522N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030539"(male genitalia development)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035198"(miRNA binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046148"(pigment biosynthetic process)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048839"(inner ear development)|go:"GO:0048852"(diencephalon morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050973"(detection of mechanical stimulus involved in equilibrioception)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0070848"(response to growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|rcsb pdb:1GT0|rcsb pdb:6HT5|reactome:R-MMU-3769402|go:"GO:0035019"(somatic stem cell population maintenance) go:"GO:0005634"(nucleus) - - figure legend:f3c f3d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2014/10/16 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:oO2sjv3/Iaj91kqGJ1L07+hhxVA10090 intact-crc:EEF6EAF86BA95E69|rigid:/3t88IgEdCOKp0lUyv6C0qrUcu4 false ha tag:?-?|necessary binding region:197-243 flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q80Z64 uniprotkb:P48432 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2313612 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:sox2_mouse(display_long)|uniprotkb:Sox2(gene name)|psi-mi:Sox2(display_short)|uniprotkb:Sox-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8837631|imex:IM-21665-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_035573.3|mint:P48432|dip:DIP-54522N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030539"(male genitalia development)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035198"(miRNA binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046148"(pigment biosynthetic process)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048839"(inner ear development)|go:"GO:0048852"(diencephalon morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050973"(detection of mechanical stimulus involved in equilibrioception)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0070848"(response to growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|rcsb pdb:1GT0|rcsb pdb:6HT5|reactome:R-MMU-3769402|go:"GO:0035019"(somatic stem cell population maintenance) - - - figure legend:f6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2014/10/16 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:oO2sjv3/Iaj91kqGJ1L07+hhxVA10090 intact-crc:D52C36C615987C71|rigid:/3t88IgEdCOKp0lUyv6C0qrUcu4 false ha tag:?-? flag tag:?-?|necessary binding region:212-233 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q80Z64 uniprotkb:P48432 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2313612 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:sox2_mouse(display_long)|uniprotkb:Sox2(gene name)|psi-mi:Sox2(display_short)|uniprotkb:Sox-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8837658|imex:IM-21665-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_035573.3|mint:P48432|dip:DIP-54522N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030539"(male genitalia development)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035198"(miRNA binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046148"(pigment biosynthetic process)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048839"(inner ear development)|go:"GO:0048852"(diencephalon morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050973"(detection of mechanical stimulus involved in equilibrioception)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0070848"(response to growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|rcsb pdb:1GT0|rcsb pdb:6HT5|reactome:R-MMU-3769402|go:"GO:0035019"(somatic stem cell population maintenance) - - - figure legend:f6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2014/10/16 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:oO2sjv3/Iaj91kqGJ1L07+hhxVA10090 intact-crc:5310D37CA839CCA9|rigid:/3t88IgEdCOKp0lUyv6C0qrUcu4 false ha tag:?-? flag tag:?-?|mutation disrupting interaction:228-228,217-217,224-224|necessary binding region:212-233 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q80Z64 uniprotkb:P48432 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2313612 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:sox2_mouse(display_long)|uniprotkb:Sox2(gene name)|psi-mi:Sox2(display_short)|uniprotkb:Sox-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8829764|imex:IM-21665-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_035573.3|mint:P48432|dip:DIP-54522N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030539"(male genitalia development)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035198"(miRNA binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046148"(pigment biosynthetic process)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048839"(inner ear development)|go:"GO:0048852"(diencephalon morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050973"(detection of mechanical stimulus involved in equilibrioception)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0070848"(response to growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|rcsb pdb:1GT0|rcsb pdb:6HT5|reactome:R-MMU-3769402|go:"GO:0035019"(somatic stem cell population maintenance) - - - figure legend:f4 f5 f6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2014/10/16 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:oO2sjv3/Iaj91kqGJ1L07+hhxVA10090 intact-crc:256B6C99A3CECC5B|rigid:/3t88IgEdCOKp0lUyv6C0qrUcu4 false ha tag:?-? necessary binding region:212-233|flag tag:?-?|mutation disrupting interaction:217-217 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P48432 uniprotkb:Q80Z64 intact:EBI-2313612 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 psi-mi:sox2_mouse(display_long)|uniprotkb:Sox2(gene name)|psi-mi:Sox2(display_short)|uniprotkb:Sox-2(gene name synonym) psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8837644|imex:IM-21665-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035573.3|mint:P48432|dip:DIP-54522N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030539"(male genitalia development)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035198"(miRNA binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046148"(pigment biosynthetic process)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048839"(inner ear development)|go:"GO:0048852"(diencephalon morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050973"(detection of mechanical stimulus involved in equilibrioception)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0070848"(response to growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|rcsb pdb:1GT0|rcsb pdb:6HT5|reactome:R-MMU-3769402|go:"GO:0035019"(somatic stem cell population maintenance) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 - - - figure legend:f6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2014/10/16 rogid:oO2sjv3/Iaj91kqGJ1L07+hhxVA10090 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 intact-crc:7AE0E8EBD9A98254|rigid:/3t88IgEdCOKp0lUyv6C0qrUcu4 false mutation disrupting interaction:228-228|necessary binding region:212-233|mutation disrupting interaction:224-224|flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q80Z64 uniprotkb:P48432 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2313612 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:sox2_mouse(display_long)|uniprotkb:Sox2(gene name)|psi-mi:Sox2(display_short)|uniprotkb:Sox-2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8821599|imex:IM-21665-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_035573.3|mint:P48432|dip:DIP-54522N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030539"(male genitalia development)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035198"(miRNA binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046148"(pigment biosynthetic process)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048839"(inner ear development)|go:"GO:0048852"(diencephalon morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050973"(detection of mechanical stimulus involved in equilibrioception)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0070848"(response to growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|rcsb pdb:1GT0|rcsb pdb:6HT5|reactome:R-MMU-3769402|go:"GO:0035019"(somatic stem cell population maintenance) go:"GO:0005634"(nucleus) - - figure legend:f3b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2014/10/16 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:oO2sjv3/Iaj91kqGJ1L07+hhxVA10090 intact-crc:9C4791F260FF00FC|rigid:/3t88IgEdCOKp0lUyv6C0qrUcu4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q80Z64 uniprotkb:P48432 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2313612 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:sox2_mouse(display_long)|uniprotkb:Sox2(gene name)|psi-mi:Sox2(display_short)|uniprotkb:Sox-2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8821594|imex:IM-21665-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_035573.3|mint:P48432|dip:DIP-54522N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030539"(male genitalia development)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035198"(miRNA binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046148"(pigment biosynthetic process)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048839"(inner ear development)|go:"GO:0048852"(diencephalon morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050973"(detection of mechanical stimulus involved in equilibrioception)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0070848"(response to growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|rcsb pdb:1GT0|rcsb pdb:6HT5|reactome:R-MMU-3769402|go:"GO:0035019"(somatic stem cell population maintenance) go:"GO:0005634"(nucleus) - - figure legend:f3a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell) - 2013/10/23 2014/10/16 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:oO2sjv3/Iaj91kqGJ1L07+hhxVA10090 intact-crc:955D42EBF853294E|rigid:/3t88IgEdCOKp0lUyv6C0qrUcu4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P48432 uniprotkb:Q80Z64 intact:EBI-2313612 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 psi-mi:sox2_mouse(display_long)|uniprotkb:Sox2(gene name)|psi-mi:Sox2(display_short)|uniprotkb:Sox-2(gene name synonym) psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:"MI:0096"(pull down) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8821623|imex:IM-21665-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035573.3|mint:P48432|dip:DIP-54522N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030539"(male genitalia development)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035198"(miRNA binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046148"(pigment biosynthetic process)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048839"(inner ear development)|go:"GO:0048852"(diencephalon morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050973"(detection of mechanical stimulus involved in equilibrioception)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0070848"(response to growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|rcsb pdb:1GT0|rcsb pdb:6HT5|reactome:R-MMU-3769402|go:"GO:0035019"(somatic stem cell population maintenance) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 - - - figure legend:f3e|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2013/10/23 2014/10/16 rogid:oO2sjv3/Iaj91kqGJ1L07+hhxVA10090 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 intact-crc:00B0AFFC7BF424CB|rigid:/3t88IgEdCOKp0lUyv6C0qrUcu4 false - maltose binding protein tag:?-?|binding-associated region:197-243|mutation disrupting interaction:198-198,203-203,208-208,213-213,218-218,223-223,228-228,233-233,238-238,243-243 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q80Z64 uniprotkb:P48432 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2313612 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:sox2_mouse(display_long)|uniprotkb:Sox2(gene name)|psi-mi:Sox2(display_short)|uniprotkb:Sox-2(gene name synonym) psi-mi:"MI:0096"(pull down) Gagliardi et al. (2013) imex:IM-21665|pubmed:23892456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8837732|imex:IM-21665-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_035573.3|mint:P48432|dip:DIP-54522N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030539"(male genitalia development)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035198"(miRNA binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046148"(pigment biosynthetic process)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048839"(inner ear development)|go:"GO:0048852"(diencephalon morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050973"(detection of mechanical stimulus involved in equilibrioception)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0070848"(response to growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|rcsb pdb:1GT0|rcsb pdb:6HT5|reactome:R-MMU-3769402|go:"GO:0035019"(somatic stem cell population maintenance) - - - figure legend:f7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/23 2014/10/16 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:oO2sjv3/Iaj91kqGJ1L07+hhxVA10090 intact-crc:DDFAEAF44C7B8250|rigid:/3t88IgEdCOKp0lUyv6C0qrUcu4 false his tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)