#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05919	uniprotkb:P01730	intact:EBI-6248147	intact:EBI-353826|uniprotkb:Q4ZGK2|uniprotkb:Q5U066|uniprotkb:Q9UDE5|uniprotkb:B2R737|uniprotkb:D3DUS5|ensembl:ENSP00000011653	psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym)	psi-mi:cd4_human(display_long)|uniprotkb:CD4(gene name)|psi-mi:CD4(display_short)|uniprotkb:T-cell surface antigen T4/Leu-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2013)	pubmed:23890821|imex:IM-21574	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8794429|imex:IM-21574-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910	refseq:NP_000607.1|rcsb pdb:1CDI|rcsb pdb:1CDJ|rcsb pdb:1CDU|rcsb pdb:1CDY|rcsb pdb:1G9M|rcsb pdb:1G9N|rcsb pdb:1GC1|rcsb pdb:1JL4|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1Q68|rcsb pdb:1RZJ|rcsb pdb:1RZK|rcsb pdb:1WBR|rcsb pdb:1WIO|rcsb pdb:1WIP|rcsb pdb:1WIQ|rcsb pdb:2B4C|rcsb pdb:1CDH|rcsb pdb:2JKR|rcsb pdb:2JKT|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-202427|reactome:R-HSA-389948|reactome:R-HSA-449836|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENST00000011653(transcript)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000973(T-cell surface antigen CD4)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015274(CD4, extracellular)|interpro:IPR021963|interpro:IPR036179|mint:P01730|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006948"(induction by virus of host cell-cell fusion)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035397"(helper T cell enhancement of adaptive immune response)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042011"(interleukin-16 binding)|go:"GO:0042012"(interleukin-16 receptor activity)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045058"(T cell selection)|go:"GO:0045121"(membrane raft)|rcsb pdb:2KLU|rcsb pdb:2NXY|rcsb pdb:2NXZ|rcsb pdb:2NY0|rcsb pdb:2NY1|rcsb pdb:2NY2|rcsb pdb:2NY3|rcsb pdb:2NY4|rcsb pdb:2NY5|rcsb pdb:2NY6|rcsb pdb:2QAD|rcsb pdb:3B71|rcsb pdb:3CD4|rcsb pdb:3J70|rcsb pdb:3JCB|rcsb pdb:3JCC|rcsb pdb:3JWD|rcsb pdb:3JWO|rcsb pdb:3LQA|rcsb pdb:3O2D|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4H8W|rcsb pdb:4JM2|rcsb pdb:4P9H|rcsb pdb:4Q6I|rcsb pdb:4R2G|rcsb pdb:4R4H|rcsb pdb:4RQS|rcsb pdb:5A7X|rcsb pdb:5A8H|rcsb pdb:5CAY|rcsb pdb:5THR|rcsb pdb:5U1F|rcsb pdb:5VN3|rcsb pdb:6CM3|rcsb pdb:6EDU|rcsb pdb:6L1Y|rcsb pdb:6MEO|rcsb pdb:6MET|rcsb pdb:6OPN|rcsb pdb:6OPO|rcsb pdb:6OPP|rcsb pdb:6OPQ|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6U0L|rcsb pdb:6U0N|rcsb pdb:6URI|rcsb pdb:6X5B|rcsb pdb:6X5C|reactome:R-HSA-1462054|reactome:R-HSA-167590|reactome:R-HSA-173107|reactome:R-HSA-180534|reactome:R-HSA-202424|ensembl:ENSG00000010610(gene)|dip:DIP-617N	-	-	-	figure legend:Supp. fig. 1F|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2013/10/14	2014/10/16	rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706	rogid:twRRh+v4xPOIlmeD9jl+Jpqjle09606	intact-crc:F38026D7421D8906|rigid:981AXdBj8JXfj/84Dh2OZRvKAPQ	false	ha tag:c-c|mutation:52-52,56-56	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05919	uniprotkb:Q13616	intact:EBI-6248147	intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398	psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym)	psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2013)	pubmed:23890821|imex:IM-21574	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8794496|imex:IM-21574-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910	refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N	-	-	-	figure legend:Fig. 2A, Supp Fig. 2A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/10/14	2014/10/16	rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706	rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606	intact-crc:CE88882E8A4C377D|rigid:sxoR7RpayuFMgRap/UHlyW8xm4c	false	mutation disrupting interaction strength:52-52,56-56|ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05919	uniprotkb:Q9Y297	intact:EBI-6248147	intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141	psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym)	psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2013)	pubmed:23890821|imex:IM-21574	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8794496|imex:IM-21574-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910	refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N	-	-	-	figure legend:Fig. 2A, Supp Fig. 2A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/10/14	2014/10/16	rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706	rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606	intact-crc:CE88882E8A4C377D|rigid:sxoR7RpayuFMgRap/UHlyW8xm4c	false	mutation disrupting interaction strength:52-52,56-56|ha tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01730	uniprotkb:P05919	intact:EBI-353826|uniprotkb:Q4ZGK2|uniprotkb:Q5U066|uniprotkb:Q9UDE5|uniprotkb:B2R737|uniprotkb:D3DUS5|ensembl:ENSP00000011653	intact:EBI-6248147	psi-mi:cd4_human(display_long)|uniprotkb:CD4(gene name)|psi-mi:CD4(display_short)|uniprotkb:T-cell surface antigen T4/Leu-3(gene name synonym)	psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2013)	pubmed:23890821|imex:IM-21574	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8794801|imex:IM-21574-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000607.1|rcsb pdb:1CDI|rcsb pdb:1CDJ|rcsb pdb:1CDU|rcsb pdb:1CDY|rcsb pdb:1G9M|rcsb pdb:1G9N|rcsb pdb:1GC1|rcsb pdb:1JL4|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1Q68|rcsb pdb:1RZJ|rcsb pdb:1RZK|rcsb pdb:1WBR|rcsb pdb:1WIO|rcsb pdb:1WIP|rcsb pdb:1WIQ|rcsb pdb:2B4C|rcsb pdb:1CDH|rcsb pdb:2JKR|rcsb pdb:2JKT|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-202427|reactome:R-HSA-389948|reactome:R-HSA-449836|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENST00000011653(transcript)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000973(T-cell surface antigen CD4)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015274(CD4, extracellular)|interpro:IPR021963|interpro:IPR036179|mint:P01730|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006948"(induction by virus of host cell-cell fusion)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035397"(helper T cell enhancement of adaptive immune response)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042011"(interleukin-16 binding)|go:"GO:0042012"(interleukin-16 receptor activity)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045058"(T cell selection)|go:"GO:0045121"(membrane raft)|rcsb pdb:2KLU|rcsb pdb:2NXY|rcsb pdb:2NXZ|rcsb pdb:2NY0|rcsb pdb:2NY1|rcsb pdb:2NY2|rcsb pdb:2NY3|rcsb pdb:2NY4|rcsb pdb:2NY5|rcsb pdb:2NY6|rcsb pdb:2QAD|rcsb pdb:3B71|rcsb pdb:3CD4|rcsb pdb:3J70|rcsb pdb:3JCB|rcsb pdb:3JCC|rcsb pdb:3JWD|rcsb pdb:3JWO|rcsb pdb:3LQA|rcsb pdb:3O2D|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4H8W|rcsb pdb:4JM2|rcsb pdb:4P9H|rcsb pdb:4Q6I|rcsb pdb:4R2G|rcsb pdb:4R4H|rcsb pdb:4RQS|rcsb pdb:5A7X|rcsb pdb:5A8H|rcsb pdb:5CAY|rcsb pdb:5THR|rcsb pdb:5U1F|rcsb pdb:5VN3|rcsb pdb:6CM3|rcsb pdb:6EDU|rcsb pdb:6L1Y|rcsb pdb:6MEO|rcsb pdb:6MET|rcsb pdb:6OPN|rcsb pdb:6OPO|rcsb pdb:6OPP|rcsb pdb:6OPQ|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6U0L|rcsb pdb:6U0N|rcsb pdb:6URI|rcsb pdb:6X5B|rcsb pdb:6X5C|reactome:R-HSA-1462054|reactome:R-HSA-167590|reactome:R-HSA-173107|reactome:R-HSA-180534|reactome:R-HSA-202424|ensembl:ENSG00000010610(gene)|dip:DIP-617N	go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910	-	-	-	figure legend:Fig. 3C|comment:When CD4 and Vpu were coincorporated into the same liposomes, they interacted with each other,  mixing separate liposomes each containing CD4 or Vpu resulted in minimal interaction|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/14	2014/10/16	rogid:twRRh+v4xPOIlmeD9jl+Jpqjle09606	rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706	intact-crc:9587D289FA944789|rigid:981AXdBj8JXfj/84Dh2OZRvKAPQ	false	mutation:393-393|radiolabel:?-?|his tag:n-n|sufficient binding region:393-458|flag tag:c-c	his tag:c-c|ha tag:c-c	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01730	uniprotkb:P05919	intact:EBI-353826|uniprotkb:Q4ZGK2|uniprotkb:Q5U066|uniprotkb:Q9UDE5|uniprotkb:B2R737|uniprotkb:D3DUS5|ensembl:ENSP00000011653	intact:EBI-6248147	psi-mi:cd4_human(display_long)|uniprotkb:CD4(gene name)|psi-mi:CD4(display_short)|uniprotkb:T-cell surface antigen T4/Leu-3(gene name synonym)	psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2013)	pubmed:23890821|imex:IM-21574	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8794471|imex:IM-21574-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000607.1|rcsb pdb:1CDI|rcsb pdb:1CDJ|rcsb pdb:1CDU|rcsb pdb:1CDY|rcsb pdb:1G9M|rcsb pdb:1G9N|rcsb pdb:1GC1|rcsb pdb:1JL4|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1Q68|rcsb pdb:1RZJ|rcsb pdb:1RZK|rcsb pdb:1WBR|rcsb pdb:1WIO|rcsb pdb:1WIP|rcsb pdb:1WIQ|rcsb pdb:2B4C|rcsb pdb:1CDH|rcsb pdb:2JKR|rcsb pdb:2JKT|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-202427|reactome:R-HSA-389948|reactome:R-HSA-449836|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENST00000011653(transcript)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000973(T-cell surface antigen CD4)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015274(CD4, extracellular)|interpro:IPR021963|interpro:IPR036179|mint:P01730|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006948"(induction by virus of host cell-cell fusion)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035397"(helper T cell enhancement of adaptive immune response)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042011"(interleukin-16 binding)|go:"GO:0042012"(interleukin-16 receptor activity)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045058"(T cell selection)|go:"GO:0045121"(membrane raft)|rcsb pdb:2KLU|rcsb pdb:2NXY|rcsb pdb:2NXZ|rcsb pdb:2NY0|rcsb pdb:2NY1|rcsb pdb:2NY2|rcsb pdb:2NY3|rcsb pdb:2NY4|rcsb pdb:2NY5|rcsb pdb:2NY6|rcsb pdb:2QAD|rcsb pdb:3B71|rcsb pdb:3CD4|rcsb pdb:3J70|rcsb pdb:3JCB|rcsb pdb:3JCC|rcsb pdb:3JWD|rcsb pdb:3JWO|rcsb pdb:3LQA|rcsb pdb:3O2D|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4H8W|rcsb pdb:4JM2|rcsb pdb:4P9H|rcsb pdb:4Q6I|rcsb pdb:4R2G|rcsb pdb:4R4H|rcsb pdb:4RQS|rcsb pdb:5A7X|rcsb pdb:5A8H|rcsb pdb:5CAY|rcsb pdb:5THR|rcsb pdb:5U1F|rcsb pdb:5VN3|rcsb pdb:6CM3|rcsb pdb:6EDU|rcsb pdb:6L1Y|rcsb pdb:6MEO|rcsb pdb:6MET|rcsb pdb:6OPN|rcsb pdb:6OPO|rcsb pdb:6OPP|rcsb pdb:6OPQ|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6U0L|rcsb pdb:6U0N|rcsb pdb:6URI|rcsb pdb:6X5B|rcsb pdb:6X5C|reactome:R-HSA-1462054|reactome:R-HSA-167590|reactome:R-HSA-173107|reactome:R-HSA-180534|reactome:R-HSA-202424|ensembl:ENSG00000010610(gene)|dip:DIP-617N	go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910	-	-	-	figure legend:Fig. 1C, 1D, Supp. Fig. 1G|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2013/10/14	2014/10/16	rogid:twRRh+v4xPOIlmeD9jl+Jpqjle09606	rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706	intact-crc:AD5E943A3CC2EE48|rigid:981AXdBj8JXfj/84Dh2OZRvKAPQ	false	necessary binding region:426-458	mutation decreasing interaction strength:21-21,17-17,25-25|mutation:52-52,56-56|ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)