#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O75164	uniprotkb:P35249	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-476655|uniprotkb:Q6FHX7|ensembl:ENSP00000296273|ensembl:ENSP00000376272|uniprotkb:D3DNV2|uniprotkb:B4DM41	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:rfc4_human(display_long)|uniprotkb:Activator 1 subunit 4(gene name synonym)|uniprotkb:Replication factor C 37 kDa subunit(gene name synonym)|uniprotkb:Activator 1 37 kDa subunit(gene name synonym)|uniprotkb:RFC4(gene name)|psi-mi:RFC4(display_short)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_002907.1|refseq:NP_853551.1|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|ensembl:ENSG00000163918(gene)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005663"(DNA replication factor C complex)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0031390"(Ctf18 RFC-like complex)|go:"GO:0031391"(Elg1 RFC-like complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR013748(Replication factor C)|interpro:IPR027417|ensembl:ENST00000296273(transcript)|ensembl:ENST00000392481(transcript)|mint:P35249|rcsb pdb:6VVO|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174411|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804756|reactome:R-HSA-69091|reactome:R-HSA-69473|reactome:R-HSA-176187|dip:DIP-24267N	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:zn+V998ZRpYIdHmG87ExC6LFc0w9606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:P35250	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-476409|uniprotkb:P32846|uniprotkb:Q9BU93|uniprotkb:D3DXG3|ensembl:ENSP00000055077|uniprotkb:B5BU07	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:rfc2_human(display_long)|uniprotkb:Activator 1 subunit 2(gene name synonym)|uniprotkb:Replication factor C 40 kDa subunit(gene name synonym)|uniprotkb:Activator 1 40 kDa subunit(gene name synonym)|uniprotkb:RFC2(gene name)|psi-mi:RFC2(display_short)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	ensembl:ENSG00000049541(gene)|ensembl:ENST00000055077(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005663"(DNA replication factor C complex)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0019899"(enzyme binding)|go:"GO:0031390"(Ctf18 RFC-like complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR013748(Replication factor C)|interpro:IPR027417|mint:P35250|rcsb pdb:6VVO|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174411|reactome:R-HSA-176187|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804756|reactome:R-HSA-69091|reactome:R-HSA-69473|refseq:NP_002905.2|refseq:NP_852136.1|refseq:NP_001265720.1|refseq:NP_001265721.1|refseq:NP_001265722.1|dip:DIP-34367N	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:36ppRbKXusdkqhmmoOTQ04BWv6I9606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:Q7Z6Z7	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:P28340	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-716569|uniprotkb:Q8NER3|uniprotkb:Q96H98|ensembl:ENSP00000406046|ensembl:ENSP00000472600|ensembl:ENSP00000473052	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:dpod1_human(display_long)|uniprotkb:3'-5' exodeoxyribonuclease(gene name synonym)|uniprotkb:DNA polymerase subunit delta p125(gene name synonym)|uniprotkb:POLD1(gene name)|psi-mi:POLD1(display_short)|uniprotkb:POLD(gene name synonym)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_002682.2|refseq:XP_011525340.1|refseq:NP_001243778.1|ensembl:ENSG00000062822(gene)|ensembl:ENST00000599857(transcript)|ensembl:ENST00000601098(transcript)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0009411"(response to UV)|ensembl:ENST00000440232(transcript)|reactome:R-HSA-5651801|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-5358606|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0019899"(enzyme binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0043625"(delta DNA polymerase complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017964|interpro:IPR023211|interpro:IPR025687|interpro:IPR036397|interpro:IPR042087|interpro:IPR043502|mint:P28340|rcsb pdb:6S1M|rcsb pdb:6S1N|rcsb pdb:6S1O|rcsb pdb:6TNY|rcsb pdb:6TNZ|reactome:R-HSA-110314|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174437|reactome:R-HSA-2564830|reactome:R-HSA-5358565|refseq:XP_016882370.1	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:bJ5Q0xOzHga/zxMOBHkuXaFXeLw9606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:Q07864	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-348526|uniprotkb:Q13533|intact:EBI-28987244|ensembl:ENSP00000322570|uniprotkb:Q86VH9	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:dpoe1_human(display_long)|uniprotkb:POLE(gene name)|psi-mi:POLE(display_short)|uniprotkb:POLE1(gene name synonym)|uniprotkb:DNA polymerase II subunit A(gene name synonym)|uniprotkb:3'-5' exodeoxyribonuclease(gene name synonym)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_006222.2|go:"GO:0008310"(single-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0048568"(embryonic organ development)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013697(Region of unknown function DUF1744)|interpro:IPR029703|interpro:IPR036397|interpro:IPR042087|interpro:IPR043502|rcsb pdb:5VBN|reactome:R-HSA-110314|reactome:R-HSA-5651801|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68952|reactome:R-HSA-68962|go:"GO:0008270"(zinc ion binding)|ensembl:ENSG00000177084(gene)|ensembl:ENST00000320574(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|ensembl:ENSP00000322570|dip:DIP-24243N	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:oPDFCAO2AeDB4UjbeBvo8DPi+ow9606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:P09884	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-850026|uniprotkb:Q86UQ7|intact:EBI-28966824|ensembl:ENSP00000368349	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:dpola_human(display_long)|uniprotkb:POLA1(gene name)|psi-mi:POLA1(display_short)|uniprotkb:POLA(gene name synonym)|uniprotkb:DNA polymerase alpha catalytic subunit p180(gene name synonym)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	ensembl:ENSP00000368349|refseq:NP_058633.2|ensembl:ENSG00000101868(gene)|ensembl:ENST00000379059(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017076"(purine nucleotide binding)|go:"GO:0019103"(pyrimidine nucleotide binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR015088(Zinc finger, DNA-directed DNA polymerase, family B, alpha)|interpro:IPR017964|interpro:IPR024647|interpro:IPR036397|interpro:IPR038256|interpro:IPR042087|interpro:IPR043502|mint:P09884|rcsb pdb:1K0P|rcsb pdb:1K18|rcsb pdb:1N5G|rcsb pdb:4Q5V|rcsb pdb:4QCL|rcsb pdb:4Y97|rcsb pdb:5EXR|rcsb pdb:5IUD|rcsb pdb:6AS7|reactome:R-HSA-113501|reactome:R-HSA-174411|reactome:R-HSA-174430|reactome:R-HSA-68952|reactome:R-HSA-68962|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-9710421	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:X/oe9TEoaNUf5UPtWEXunsFtRZg9606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:P40937	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-712376|ensembl:ENSP00000408295|uniprotkb:A8MZ62|uniprotkb:B3KSX8	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:rfc5_human(display_long)|uniprotkb:Activator 1 subunit 5(gene name synonym)|uniprotkb:Replication factor C 36 kDa subunit(gene name synonym)|uniprotkb:Activator 1 36 kDa subunit(gene name synonym)|uniprotkb:RFC5(gene name)|psi-mi:RFC5(display_short)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_031396.1|refseq:NP_853556.2|ensembl:ENSG00000111445(gene)|ensembl:ENST00000454402(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005663"(DNA replication factor C complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0019899"(enzyme binding)|go:"GO:0031390"(Ctf18 RFC-like complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR013748(Replication factor C)|interpro:IPR027417|mint:P40937|rcsb pdb:1LFS|rcsb pdb:6VVO|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174411|reactome:R-HSA-176187|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804756|reactome:R-HSA-69091|reactome:R-HSA-69473|refseq:XP_011536945.1|refseq:XP_011536947.1|refseq:NP_001123584.1|refseq:NP_001123585.1|dip:DIP-36433N	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:F7oadHDk6fkhHn+3rDF9K2JHSl49606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:Q9Y4A5	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-399128|uniprotkb:O75218|uniprotkb:Q9Y631|uniprotkb:Q9Y6H4|uniprotkb:A4D265|ensembl:ENSP00000352925	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:trrap_human(display_long)|uniprotkb:TRRAP(gene name)|psi-mi:TRRAP(display_short)|uniprotkb:PAF400(gene name synonym)|uniprotkb:350/400 kDa PCAF-associated factor(gene name synonym)|uniprotkb:STAF40(gene name synonym)|uniprotkb:Tra1 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_003487.1|ensembl:ENSG00000196367(gene)|ensembl:ENST00000359863(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0000125"|go:"GO:0000812"(Swr1 complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016310"(phosphorylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0030914"|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033317|mint:Q9Y4A5|reactome:R-HSA-201722|reactome:R-HSA-3214847|reactome:R-HSA-5689880|refseq:NP_001231509.1|dip:DIP-28149N	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:bGoQLXxMT0zZ0jVW+2s4hUwnBA49606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:Q04837	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-353460|ensembl:ENSP00000265304|ensembl:ENSP00000419388|ensembl:ENSP00000419541|ensembl:ENSP00000419665|ensembl:ENSP00000420485|ensembl:ENSP00000458815|ensembl:ENSP00000459208|ensembl:ENSP00000459367|ensembl:ENSP00000460028|ensembl:ENSP00000461884|ensembl:ENSP00000480488	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:ssbp_human(display_long)|uniprotkb:SSBP1(gene name)|psi-mi:SSBP1(display_short)|uniprotkb:SSBP(gene name synonym)|uniprotkb:PWP1-interacting protein 17(gene name synonym)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_003134.1|refseq:NP_001243439.1|refseq:NP_001243440.1|refseq:NP_001243441.1|refseq:NP_001243442.1|ensembl:ENSG00000106028(gene)|ensembl:ENSG00000262771(gene)|ensembl:ENST00000265304(transcript)|ensembl:ENST00000465582(transcript)|ensembl:ENST00000481508(transcript)|ensembl:ENST00000484178(transcript)|ensembl:ENST00000498107(transcript)|ensembl:ENST00000570667(transcript)|ensembl:ENST00000571430(transcript)|ensembl:ENST00000574199(transcript)|ensembl:ENST00000575059(transcript)|ensembl:ENST00000576834(transcript)|ensembl:ENST00000612337(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0009295"(nucleoid)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1905776"(positive regulation of DNA helicase activity)|interpro:IPR000424(Primosome PriB/single-strand DNA-binding)|interpro:IPR011344(Single-strand DNA-binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:Q04837|rcsb pdb:1S3O|rcsb pdb:2DUD|rcsb pdb:3ULL|rcsb pdb:6RUP|reactome:R-HSA-2151201	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:W/7kbgBRtYcjJfr2XbA1OK9BOS49606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:P04637	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:Q92900	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-373471|uniprotkb:O00239|uniprotkb:O43343|uniprotkb:Q86Z25|uniprotkb:Q92842|ensembl:ENSP00000470142	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:rent1_human(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:RENT1(gene name synonym)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_002902.2|refseq:NP_001284478.1|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000599848(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|mint:Q92900|rcsb pdb:2GJK|rcsb pdb:2GK6|rcsb pdb:2GK7|rcsb pdb:2IYK|rcsb pdb:2WJV|rcsb pdb:2WJY|rcsb pdb:2XZO|rcsb pdb:2XZP|rcsb pdb:6EJ5|rcsb pdb:6Z3R|reactome:R-HSA-975956|reactome:R-HSA-975957|go:"GO:0006406"(mRNA export from nucleus)|dip:DIP-29875N	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:ORqXFPAa7qA8cwM5qcNodIF0q/s9606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:Q96S55	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-2513471|ensembl:ENSP00000370150|ensembl:ENSP00000477551|uniprotkb:Q9NRJ6|uniprotkb:Q5W0E2|uniprotkb:Q53EP6|uniprotkb:Q8WV26|uniprotkb:Q5W0E4|uniprotkb:Q59ET8|uniprotkb:Q9H681|uniprotkb:B2RDB0	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:wrip1_human(display_long)|uniprotkb:WRNIP1(gene name)|psi-mi:WRNIP1(display_short)|uniprotkb:WHIP(gene name synonym)|uniprotkb:Werner helicase-interacting protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	ensembl:ENSG00000124535(gene)|ensembl:ENST00000380773(transcript)|ensembl:ENST00000618555(transcript)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR021886|interpro:IPR027417|interpro:IPR032423|interpro:IPR040539|mint:Q96S55|rcsb pdb:3VHS|rcsb pdb:3VHT|go:"GO:0017116"(single-stranded DNA helicase activity)|refseq:NP_064520.2|refseq:NP_569079.1	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:Q8qVSqItgTO7sbWGAQ3XAoFFUr89606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:P33992	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:P25205	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:P33991	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:Q16531	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:Q96EY1	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-356767|uniprotkb:O75472|uniprotkb:Q8WUJ6|uniprotkb:Q8WXJ3|uniprotkb:Q96D76|uniprotkb:Q96IV1|uniprotkb:Q9NYH8|uniprotkb:B2RAJ5|uniprotkb:B4DI33|uniprotkb:E7ES32|ensembl:ENSP00000262375|ensembl:ENSP00000477570	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:dnja3_human(display_long)|uniprotkb:DNAJA3(gene name)|psi-mi:DNAJA3(display_short)|uniprotkb:TID1(gene name synonym)|uniprotkb:HCA57(gene name synonym)|uniprotkb:Tumorous imaginal discs protein Tid56 homolog(gene name synonym)|uniprotkb:DnaJ protein Tid-1(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 57(gene name synonym)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_001273445.1|refseq:NP_001128582.1|refseq:NP_005138.3|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0106137"(IkappaB kinase complex binding)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|mint:Q96EY1|rcsb pdb:2CTT|rcsb pdb:2DN9|rcsb pdb:6IWS|ensembl:ENSG00000103423(gene)|ensembl:ENSG00000276726(gene)|ensembl:ENST00000262375(transcript)|ensembl:ENST00000612103(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005133"(interferon-gamma receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007569"(cell aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051059"(NF-kappaB binding)|dip:DIP-33870N	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:WnRYdQ9E3yGbSlq1SSGTX9k+3uA9606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:P06493	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:Q9HB71	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:P33993	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:P33316	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-353224|uniprotkb:O14785|uniprotkb:Q16708|uniprotkb:Q16860|uniprotkb:Q96Q81|uniprotkb:A8K650|uniprotkb:B4DPR5|uniprotkb:Q6FHN1|uniprotkb:Q6NSA3|ensembl:ENSP00000370376	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:dut_human(display_long)|uniprotkb:DUT(gene name)|psi-mi:DUT(display_short)|uniprotkb:dUTP pyrophosphatase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_001020419.1|refseq:NP_001020420.1|refseq:NP_001939.1|rcsb pdb:1Q5U|rcsb pdb:2HQU|rcsb pdb:3ARA|rcsb pdb:3ARN|rcsb pdb:3EHW|rcsb pdb:4MZ5|rcsb pdb:4MZ6|rcsb pdb:5H4J|reactome:R-HSA-499943|ensembl:ENSG00000128951(gene)|ensembl:ENST00000331200(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004170"(dUTP diphosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006226"(dUMP biosynthetic process)|go:"GO:0006260"(DNA replication)|go:"GO:0046081"(dUTP catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008181(DeoxyUTP pyrophosphatase subfamily 1)|interpro:IPR029054|interpro:IPR033704|interpro:IPR036157|rcsb pdb:1Q5H|refseq:NP_001317215.1	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:lHET9Z1Rre4xbVStybz65KJ8QLk9606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:Q13616	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short)	psi-mi:"MI:0096"(pull down)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793243|imex:IM-21741-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606	intact-crc:502EC6045A95974F|rigid:PBm3tvb7ltilYsz9vi9xZU14s4Y	false	tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O75164	uniprotkb:P49736	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-374819|uniprotkb:Q14577|uniprotkb:Q15023|uniprotkb:Q8N2V1|uniprotkb:Q969W7|uniprotkb:Q96AE1|uniprotkb:Q9BRM7|ensembl:ENSP00000265056	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:mcm2_human(display_long)|uniprotkb:MCM2(gene name)|psi-mi:MCM2(display_short)|uniprotkb:BM28(gene name synonym)|uniprotkb:CDCL1(gene name synonym)|uniprotkb:KIAA0030(gene name synonym)|uniprotkb:Minichromosome maintenance protein 2 homolog(gene name synonym)|uniprotkb:Nuclear protein BM28(gene name synonym)|uniprotkb:CCNL1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793277|imex:IM-21741-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	ensembl:ENSG00000073111(gene)|ensembl:ENST00000265056(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006915"(apoptotic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0042393"(histone binding)|go:"GO:0042555"(MCM complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0071162"(CMG complex)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090102"(cochlea development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001208(MCM)|interpro:IPR008045(MCM protein 2)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P49736|rcsb pdb:4UUZ|rcsb pdb:5BNV|rcsb pdb:5BNX|rcsb pdb:5BO0|rcsb pdb:5C3I|rcsb pdb:5JA4|rcsb pdb:6XTX|rcsb pdb:6XTY|rcsb pdb:6YA7|rcsb pdb:7CIZ|rcsb pdb:7CJ0|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|refseq:NP_004517.2|dip:DIP-31732N	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:Jt9ODNyJBwtwQ0pb/+X46vtHfE09606	intact-crc:8DBC8BE797571BB2|rigid:uSlw5g70EyACA3eFAV8P15JrcGc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75164	uniprotkb:P25205	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793277|imex:IM-21741-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606	intact-crc:8DBC8BE797571BB2|rigid:uSlw5g70EyACA3eFAV8P15JrcGc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75164	uniprotkb:P33993	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8793277|imex:IM-21741-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606	intact-crc:8DBC8BE797571BB2|rigid:uSlw5g70EyACA3eFAV8P15JrcGc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75164	uniprotkb:P33993	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8873699|imex:IM-21741-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N	-	-	-	figure legend:Supp. Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606	intact-crc:A3BDE8CA29E2E2E2|rigid:uSlw5g70EyACA3eFAV8P15JrcGc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75164	uniprotkb:P25205	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8873699|imex:IM-21741-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N	-	-	-	figure legend:Supp. Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606	intact-crc:A3BDE8CA29E2E2E2|rigid:uSlw5g70EyACA3eFAV8P15JrcGc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75164	uniprotkb:P49736	intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473	intact:EBI-374819|uniprotkb:Q14577|uniprotkb:Q15023|uniprotkb:Q8N2V1|uniprotkb:Q969W7|uniprotkb:Q96AE1|uniprotkb:Q9BRM7|ensembl:ENSP00000265056	psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)	psi-mi:mcm2_human(display_long)|uniprotkb:MCM2(gene name)|psi-mi:MCM2(display_short)|uniprotkb:BM28(gene name synonym)|uniprotkb:CDCL1(gene name synonym)|uniprotkb:KIAA0030(gene name synonym)|uniprotkb:Minichromosome maintenance protein 2 homolog(gene name synonym)|uniprotkb:Nuclear protein BM28(gene name synonym)|uniprotkb:CCNL1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Black et al. (2013)	pubmed:23871696|imex:IM-21741	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8873699|imex:IM-21741-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569	ensembl:ENSG00000073111(gene)|ensembl:ENST00000265056(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006915"(apoptotic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0042393"(histone binding)|go:"GO:0042555"(MCM complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0071162"(CMG complex)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090102"(cochlea development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001208(MCM)|interpro:IPR008045(MCM protein 2)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P49736|rcsb pdb:4UUZ|rcsb pdb:5BNV|rcsb pdb:5BNX|rcsb pdb:5BO0|rcsb pdb:5C3I|rcsb pdb:5JA4|rcsb pdb:6XTX|rcsb pdb:6XTY|rcsb pdb:6YA7|rcsb pdb:7CIZ|rcsb pdb:7CJ0|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|refseq:NP_004517.2|dip:DIP-31732N	-	-	-	figure legend:Supp. Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/10/11	2014/10/16	rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606	rogid:Jt9ODNyJBwtwQ0pb/+X46vtHfE09606	intact-crc:A3BDE8CA29E2E2E2|rigid:uSlw5g70EyACA3eFAV8P15JrcGc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)