#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01374	uniprotkb:P01374	intact:EBI-524105|uniprotkb:Q8N4C3|uniprotkb:Q9UKS8|ensembl:ENSP00000395976|ensembl:ENSP00000402413|ensembl:ENSP00000403495|ensembl:ENSP00000412555|ensembl:ENSP00000413450|ensembl:ENSP00000416509	intact:EBI-524105|uniprotkb:Q8N4C3|uniprotkb:Q9UKS8|ensembl:ENSP00000395976|ensembl:ENSP00000402413|ensembl:ENSP00000403495|ensembl:ENSP00000412555|ensembl:ENSP00000413450|ensembl:ENSP00000416509	psi-mi:tnfb_human(display_long)|uniprotkb:TNF-beta(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 1(gene name synonym)|uniprotkb:LTA(gene name)|psi-mi:LTA(display_short)|uniprotkb:TNFB(gene name synonym)|uniprotkb:TNFSF1(gene name synonym)	psi-mi:tnfb_human(display_long)|uniprotkb:TNF-beta(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 1(gene name synonym)|uniprotkb:LTA(gene name)|psi-mi:LTA(display_short)|uniprotkb:TNFB(gene name synonym)|uniprotkb:TNFSF1(gene name synonym)	psi-mi:"MI:0276"(blue native page)	Etemadi et al. (2013)	mint:MINT-8432069|mint:fj-13-0074|pubmed:23815148|imex:IM-22121	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8538868|imex:IM-22121-1|mint:MINT-8434858	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000226979(gene)|ensembl:ENSG00000230279(gene)|ensembl:ENSG00000231408(gene)|ensembl:ENST00000412851(transcript)|ensembl:ENST00000418386(transcript)|ensembl:ENST00000426845(transcript)|ensembl:ENST00000436519(transcript)|ensembl:ENST00000454783(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|ensembl:ENST00000454550(transcript)|go:"GO:0007584"(response to nutrient)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048535"(lymph node development)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR002960(Tumour necrosis factor beta/lymphotoxin alpha)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|rcsb pdb:1TNR|rcsb pdb:4MXV|go:"GO:0060252"(positive regulation of glial cell proliferation)|rcsb pdb:4MXW|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_011512919.1|refseq:XP_011512920.1|refseq:XP_011512917.1|refseq:XP_011512918.1|refseq:NP_000586.2|refseq:NP_001153212.1|dip:DIP-2910N|mint:MINT-8434860(identity)	ensembl:ENSG00000226979(gene)|ensembl:ENSG00000230279(gene)|ensembl:ENSG00000231408(gene)|ensembl:ENST00000412851(transcript)|ensembl:ENST00000418386(transcript)|ensembl:ENST00000426845(transcript)|ensembl:ENST00000436519(transcript)|ensembl:ENST00000454783(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|ensembl:ENST00000454550(transcript)|go:"GO:0007584"(response to nutrient)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048535"(lymph node development)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR002960(Tumour necrosis factor beta/lymphotoxin alpha)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|rcsb pdb:1TNR|rcsb pdb:4MXV|go:"GO:0060252"(positive regulation of glial cell proliferation)|rcsb pdb:4MXW|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_011512919.1|refseq:XP_011512920.1|refseq:XP_011512917.1|refseq:XP_011512918.1|refseq:NP_000586.2|refseq:NP_001153212.1|dip:DIP-2910N|mint:MINT-8434860(identity)	-	comment:"Stoichiometry: 3.0"	comment:"Stoichiometry: 3.0"	figure legend:sf1c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/10	2014/10/16	rogid:DRe0vNUyg7gLQTNqptel3XPDY3w9606	rogid:DRe0vNUyg7gLQTNqptel3XPDY3w9606	intact-crc:23E36BD43B97AB36|rigid:UeSMeQxUGSAyi/1Uf6l3e804vbM	false	-	-	3	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P01375	uniprotkb:P01375	intact:EBI-359977|uniprotkb:O43647|uniprotkb:Q9P1Q2|uniprotkb:Q9UIV3|ensembl:ENSP00000365290|ensembl:ENSP00000372988|ensembl:ENSP00000389490|ensembl:ENSP00000389492|ensembl:ENSP00000392858|ensembl:ENSP00000398698|ensembl:ENSP00000410668	intact:EBI-359977|uniprotkb:O43647|uniprotkb:Q9P1Q2|uniprotkb:Q9UIV3|ensembl:ENSP00000365290|ensembl:ENSP00000372988|ensembl:ENSP00000389490|ensembl:ENSP00000389492|ensembl:ENSP00000392858|ensembl:ENSP00000398698|ensembl:ENSP00000410668	psi-mi:tnfa_human(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)	psi-mi:tnfa_human(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)	psi-mi:"MI:0276"(blue native page)	Etemadi et al. (2013)	mint:MINT-8432069|mint:fj-13-0074|pubmed:23815148|imex:IM-22121	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8538876|imex:IM-22121-2|mint:MINT-8434864	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204490(gene)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050890"(cognition)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0002020"(protease binding)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009615"(response to virus)|go:"GO:0009651"(response to salt stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|ensembl:ENSG00000206439(gene)|ensembl:ENSG00000223952(gene)|ensembl:ENSG00000228321(gene)|ensembl:ENSG00000228849(gene)|ensembl:ENSG00000230108(gene)|ensembl:ENSG00000232810(gene)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|ensembl:ENST00000376122(transcript)|ensembl:ENST00000383496(transcript)|ensembl:ENST00000412275(transcript)|ensembl:ENST00000420425(transcript)|ensembl:ENST00000443707(transcript)|ensembl:ENST00000448781(transcript)|ensembl:ENST00000449264(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-HSA-75893|reactome:R-HSA-6785807|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|mint:P01375|rcsb pdb:1A8M|rcsb pdb:1TNF|rcsb pdb:2AZ5|rcsb pdb:2E7A|rcsb pdb:2TUN|rcsb pdb:2ZJC|rcsb pdb:2ZPX|rcsb pdb:3ALQ|rcsb pdb:3IT8|rcsb pdb:3L9J|rcsb pdb:3WD5|rcsb pdb:4G3Y|rcsb pdb:4TSV|rcsb pdb:4TWT|rcsb pdb:4Y6O|rcsb pdb:5M2I|rcsb pdb:5M2J|rcsb pdb:5M2M|rcsb pdb:5MU8|rcsb pdb:5TSW|rcsb pdb:5WUX|rcsb pdb:5YOY|rcsb pdb:6OOY|rcsb pdb:6OOZ|rcsb pdb:6OP0|rcsb pdb:6RMJ|rcsb pdb:6X81|rcsb pdb:6X82|rcsb pdb:6X83|rcsb pdb:6X85|rcsb pdb:6X86|rcsb pdb:7ASY|rcsb pdb:7AT7|rcsb pdb:7ATB|rcsb pdb:7JRA|rcsb pdb:7KP9|rcsb pdb:7KPA|rcsb pdb:7KPB|reactome:R-HSA-381340|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:5UUI|reactome:R-HSA-5668541|reactome:R-HSA-6783783|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|refseq:NP_000585.2|dip:DIP-2895N|mint:MINT-8434866(identity)	ensembl:ENSG00000204490(gene)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050890"(cognition)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0002020"(protease binding)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009615"(response to virus)|go:"GO:0009651"(response to salt stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|ensembl:ENSG00000206439(gene)|ensembl:ENSG00000223952(gene)|ensembl:ENSG00000228321(gene)|ensembl:ENSG00000228849(gene)|ensembl:ENSG00000230108(gene)|ensembl:ENSG00000232810(gene)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|ensembl:ENST00000376122(transcript)|ensembl:ENST00000383496(transcript)|ensembl:ENST00000412275(transcript)|ensembl:ENST00000420425(transcript)|ensembl:ENST00000443707(transcript)|ensembl:ENST00000448781(transcript)|ensembl:ENST00000449264(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-HSA-75893|reactome:R-HSA-6785807|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|mint:P01375|rcsb pdb:1A8M|rcsb pdb:1TNF|rcsb pdb:2AZ5|rcsb pdb:2E7A|rcsb pdb:2TUN|rcsb pdb:2ZJC|rcsb pdb:2ZPX|rcsb pdb:3ALQ|rcsb pdb:3IT8|rcsb pdb:3L9J|rcsb pdb:3WD5|rcsb pdb:4G3Y|rcsb pdb:4TSV|rcsb pdb:4TWT|rcsb pdb:4Y6O|rcsb pdb:5M2I|rcsb pdb:5M2J|rcsb pdb:5M2M|rcsb pdb:5MU8|rcsb pdb:5TSW|rcsb pdb:5WUX|rcsb pdb:5YOY|rcsb pdb:6OOY|rcsb pdb:6OOZ|rcsb pdb:6OP0|rcsb pdb:6RMJ|rcsb pdb:6X81|rcsb pdb:6X82|rcsb pdb:6X83|rcsb pdb:6X85|rcsb pdb:6X86|rcsb pdb:7ASY|rcsb pdb:7AT7|rcsb pdb:7ATB|rcsb pdb:7JRA|rcsb pdb:7KP9|rcsb pdb:7KPA|rcsb pdb:7KPB|reactome:R-HSA-381340|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:5UUI|reactome:R-HSA-5668541|reactome:R-HSA-6783783|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|refseq:NP_000585.2|dip:DIP-2895N|mint:MINT-8434866(identity)	-	comment:"Stoichiometry: 3.0"	comment:"Stoichiometry: 3.0"	figure legend:sf1c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/10	2014/10/16	rogid:27bbNim4bHFyBJscZC+/v9o96+g9606	rogid:27bbNim4bHFyBJscZC+/v9o96+g9606	intact-crc:A98963B4DC5F0BDF|rigid:Y+GA8H3MXFNDG6zXVrY3mvqDA+I	false	-	-	3	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P01374	uniprotkb:Q13490	intact:EBI-524105|uniprotkb:Q8N4C3|uniprotkb:Q9UKS8|ensembl:ENSP00000395976|ensembl:ENSP00000402413|ensembl:ENSP00000403495|ensembl:ENSP00000412555|ensembl:ENSP00000413450|ensembl:ENSP00000416509	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	psi-mi:tnfb_human(display_long)|uniprotkb:TNF-beta(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 1(gene name synonym)|uniprotkb:LTA(gene name)|psi-mi:LTA(display_short)|uniprotkb:TNFB(gene name synonym)|uniprotkb:TNFSF1(gene name synonym)	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Etemadi et al. (2013)	mint:MINT-8432069|mint:fj-13-0074|pubmed:23815148|imex:IM-22121	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8538894|imex:IM-22121-3|mint:MINT-8434873	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000226979(gene)|ensembl:ENSG00000230279(gene)|ensembl:ENSG00000231408(gene)|ensembl:ENST00000412851(transcript)|ensembl:ENST00000418386(transcript)|ensembl:ENST00000426845(transcript)|ensembl:ENST00000436519(transcript)|ensembl:ENST00000454783(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|ensembl:ENST00000454550(transcript)|go:"GO:0007584"(response to nutrient)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048535"(lymph node development)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR002960(Tumour necrosis factor beta/lymphotoxin alpha)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|rcsb pdb:1TNR|rcsb pdb:4MXV|go:"GO:0060252"(positive regulation of glial cell proliferation)|rcsb pdb:4MXW|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_011512919.1|refseq:XP_011512920.1|refseq:XP_011512917.1|refseq:XP_011512918.1|refseq:NP_000586.2|refseq:NP_001153212.1|dip:DIP-2910N|mint:MINT-8434875(identity)	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|mint:MINT-8434876(identity)	-	-	-	figure legend:f3d|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha)	-	2013/07/10	2014/10/16	rogid:DRe0vNUyg7gLQTNqptel3XPDY3w9606	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	intact-crc:4285A1055157C30D|rigid:ZQC1dNxq00YJ63Z+Yap/Moj3N3Y	false	tandem tag:?-?(MINT-8434880)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01374	uniprotkb:Q13546	intact:EBI-524105|uniprotkb:Q8N4C3|uniprotkb:Q9UKS8|ensembl:ENSP00000395976|ensembl:ENSP00000402413|ensembl:ENSP00000403495|ensembl:ENSP00000412555|ensembl:ENSP00000413450|ensembl:ENSP00000416509	intact:EBI-358507|uniprotkb:A0AV89|uniprotkb:B2RAG1|uniprotkb:B4E3F9|uniprotkb:Q59H33|uniprotkb:Q13180|ensembl:ENSP00000259808	psi-mi:tnfb_human(display_long)|uniprotkb:TNF-beta(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 1(gene name synonym)|uniprotkb:LTA(gene name)|psi-mi:LTA(display_short)|uniprotkb:TNFB(gene name synonym)|uniprotkb:TNFSF1(gene name synonym)	psi-mi:ripk1_human(display_long)|uniprotkb:RIPK1(gene name)|psi-mi:RIPK1(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:RIP1(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Etemadi et al. (2013)	mint:MINT-8432069|mint:fj-13-0074|pubmed:23815148|imex:IM-22121	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8538894|imex:IM-22121-3|mint:MINT-8434873	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000226979(gene)|ensembl:ENSG00000230279(gene)|ensembl:ENSG00000231408(gene)|ensembl:ENST00000412851(transcript)|ensembl:ENST00000418386(transcript)|ensembl:ENST00000426845(transcript)|ensembl:ENST00000436519(transcript)|ensembl:ENST00000454783(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|ensembl:ENST00000454550(transcript)|go:"GO:0007584"(response to nutrient)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048535"(lymph node development)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR002960(Tumour necrosis factor beta/lymphotoxin alpha)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|rcsb pdb:1TNR|rcsb pdb:4MXV|go:"GO:0060252"(positive regulation of glial cell proliferation)|rcsb pdb:4MXW|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_011512919.1|refseq:XP_011512920.1|refseq:XP_011512917.1|refseq:XP_011512918.1|refseq:NP_000586.2|refseq:NP_001153212.1|dip:DIP-2910N|mint:MINT-8434875(identity)	refseq:NP_003795.2|refseq:XP_005249514.2|dip:DIP-433N|ensembl:ENSG00000137275(gene)|ensembl:ENST00000259808(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010008"(endosome membrane)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q13546|rcsb pdb:4ITH|rcsb pdb:4ITI|rcsb pdb:4ITJ|rcsb pdb:4NEU|rcsb pdb:5HX6|rcsb pdb:5TX5|rcsb pdb:5V7Z|rcsb pdb:6AC5|rcsb pdb:6C3E|rcsb pdb:6C4D|rcsb pdb:6HHO|rcsb pdb:6NW2|rcsb pdb:6NYH|rcsb pdb:6OCQ|rcsb pdb:6R5F|rcsb pdb:6RLN|reactome:R-HSA-140534|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-937041|reactome:R-HSA-9679191|reactome:R-HSA-9686347|reactome:R-HSA-9693928|go:"GO:0070266"(necroptotic process)|mint:MINT-8434877(identity)	-	-	-	figure legend:f3d|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha)	-	2013/07/10	2014/10/16	rogid:DRe0vNUyg7gLQTNqptel3XPDY3w9606	rogid:P1pQanTLVGi2Oic1QNeELpcdL2M9606	intact-crc:4285A1055157C30D|rigid:ZQC1dNxq00YJ63Z+Yap/Moj3N3Y	false	tandem tag:?-?(MINT-8434880)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01375	uniprotkb:Q13490	intact:EBI-359977|uniprotkb:O43647|uniprotkb:Q9P1Q2|uniprotkb:Q9UIV3|ensembl:ENSP00000365290|ensembl:ENSP00000372988|ensembl:ENSP00000389490|ensembl:ENSP00000389492|ensembl:ENSP00000392858|ensembl:ENSP00000398698|ensembl:ENSP00000410668	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	psi-mi:tnfa_human(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Etemadi et al. (2013)	mint:MINT-8432069|mint:fj-13-0074|pubmed:23815148|imex:IM-22121	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8538911|imex:IM-22121-4|mint:MINT-8434888	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204490(gene)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050890"(cognition)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0002020"(protease binding)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009615"(response to virus)|go:"GO:0009651"(response to salt stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|ensembl:ENSG00000206439(gene)|ensembl:ENSG00000223952(gene)|ensembl:ENSG00000228321(gene)|ensembl:ENSG00000228849(gene)|ensembl:ENSG00000230108(gene)|ensembl:ENSG00000232810(gene)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|ensembl:ENST00000376122(transcript)|ensembl:ENST00000383496(transcript)|ensembl:ENST00000412275(transcript)|ensembl:ENST00000420425(transcript)|ensembl:ENST00000443707(transcript)|ensembl:ENST00000448781(transcript)|ensembl:ENST00000449264(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-HSA-75893|reactome:R-HSA-6785807|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|mint:P01375|rcsb pdb:1A8M|rcsb pdb:1TNF|rcsb pdb:2AZ5|rcsb pdb:2E7A|rcsb pdb:2TUN|rcsb pdb:2ZJC|rcsb pdb:2ZPX|rcsb pdb:3ALQ|rcsb pdb:3IT8|rcsb pdb:3L9J|rcsb pdb:3WD5|rcsb pdb:4G3Y|rcsb pdb:4TSV|rcsb pdb:4TWT|rcsb pdb:4Y6O|rcsb pdb:5M2I|rcsb pdb:5M2J|rcsb pdb:5M2M|rcsb pdb:5MU8|rcsb pdb:5TSW|rcsb pdb:5WUX|rcsb pdb:5YOY|rcsb pdb:6OOY|rcsb pdb:6OOZ|rcsb pdb:6OP0|rcsb pdb:6RMJ|rcsb pdb:6X81|rcsb pdb:6X82|rcsb pdb:6X83|rcsb pdb:6X85|rcsb pdb:6X86|rcsb pdb:7ASY|rcsb pdb:7AT7|rcsb pdb:7ATB|rcsb pdb:7JRA|rcsb pdb:7KP9|rcsb pdb:7KPA|rcsb pdb:7KPB|reactome:R-HSA-381340|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:5UUI|reactome:R-HSA-5668541|reactome:R-HSA-6783783|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|refseq:NP_000585.2|dip:DIP-2895N|mint:MINT-8434894(identity)	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|mint:MINT-8434892(identity)	-	-	-	figure legend:f3d|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha)	-	2013/07/10	2014/10/16	rogid:27bbNim4bHFyBJscZC+/v9o96+g9606	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	intact-crc:6226CCFCB0979430|rigid:IZ8jJsdr9MZMFs1f7q/lSA9paqE	false	tandem tag:?-?(MINT-8434895)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01375	uniprotkb:Q13546	intact:EBI-359977|uniprotkb:O43647|uniprotkb:Q9P1Q2|uniprotkb:Q9UIV3|ensembl:ENSP00000365290|ensembl:ENSP00000372988|ensembl:ENSP00000389490|ensembl:ENSP00000389492|ensembl:ENSP00000392858|ensembl:ENSP00000398698|ensembl:ENSP00000410668	intact:EBI-358507|uniprotkb:A0AV89|uniprotkb:B2RAG1|uniprotkb:B4E3F9|uniprotkb:Q59H33|uniprotkb:Q13180|ensembl:ENSP00000259808	psi-mi:tnfa_human(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)	psi-mi:ripk1_human(display_long)|uniprotkb:RIPK1(gene name)|psi-mi:RIPK1(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:RIP1(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Etemadi et al. (2013)	mint:MINT-8432069|mint:fj-13-0074|pubmed:23815148|imex:IM-22121	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8538911|imex:IM-22121-4|mint:MINT-8434888	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204490(gene)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050890"(cognition)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0002020"(protease binding)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009615"(response to virus)|go:"GO:0009651"(response to salt stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|ensembl:ENSG00000206439(gene)|ensembl:ENSG00000223952(gene)|ensembl:ENSG00000228321(gene)|ensembl:ENSG00000228849(gene)|ensembl:ENSG00000230108(gene)|ensembl:ENSG00000232810(gene)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|ensembl:ENST00000376122(transcript)|ensembl:ENST00000383496(transcript)|ensembl:ENST00000412275(transcript)|ensembl:ENST00000420425(transcript)|ensembl:ENST00000443707(transcript)|ensembl:ENST00000448781(transcript)|ensembl:ENST00000449264(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-HSA-75893|reactome:R-HSA-6785807|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|mint:P01375|rcsb pdb:1A8M|rcsb pdb:1TNF|rcsb pdb:2AZ5|rcsb pdb:2E7A|rcsb pdb:2TUN|rcsb pdb:2ZJC|rcsb pdb:2ZPX|rcsb pdb:3ALQ|rcsb pdb:3IT8|rcsb pdb:3L9J|rcsb pdb:3WD5|rcsb pdb:4G3Y|rcsb pdb:4TSV|rcsb pdb:4TWT|rcsb pdb:4Y6O|rcsb pdb:5M2I|rcsb pdb:5M2J|rcsb pdb:5M2M|rcsb pdb:5MU8|rcsb pdb:5TSW|rcsb pdb:5WUX|rcsb pdb:5YOY|rcsb pdb:6OOY|rcsb pdb:6OOZ|rcsb pdb:6OP0|rcsb pdb:6RMJ|rcsb pdb:6X81|rcsb pdb:6X82|rcsb pdb:6X83|rcsb pdb:6X85|rcsb pdb:6X86|rcsb pdb:7ASY|rcsb pdb:7AT7|rcsb pdb:7ATB|rcsb pdb:7JRA|rcsb pdb:7KP9|rcsb pdb:7KPA|rcsb pdb:7KPB|reactome:R-HSA-381340|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:5UUI|reactome:R-HSA-5668541|reactome:R-HSA-6783783|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|refseq:NP_000585.2|dip:DIP-2895N|mint:MINT-8434894(identity)	refseq:NP_003795.2|refseq:XP_005249514.2|dip:DIP-433N|ensembl:ENSG00000137275(gene)|ensembl:ENST00000259808(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010008"(endosome membrane)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q13546|rcsb pdb:4ITH|rcsb pdb:4ITI|rcsb pdb:4ITJ|rcsb pdb:4NEU|rcsb pdb:5HX6|rcsb pdb:5TX5|rcsb pdb:5V7Z|rcsb pdb:6AC5|rcsb pdb:6C3E|rcsb pdb:6C4D|rcsb pdb:6HHO|rcsb pdb:6NW2|rcsb pdb:6NYH|rcsb pdb:6OCQ|rcsb pdb:6R5F|rcsb pdb:6RLN|reactome:R-HSA-140534|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-937041|reactome:R-HSA-9679191|reactome:R-HSA-9686347|reactome:R-HSA-9693928|go:"GO:0070266"(necroptotic process)|mint:MINT-8434890(identity)	-	-	-	figure legend:f3d|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha)	-	2013/07/10	2014/10/16	rogid:27bbNim4bHFyBJscZC+/v9o96+g9606	rogid:P1pQanTLVGi2Oic1QNeELpcdL2M9606	intact-crc:6226CCFCB0979430|rigid:IZ8jJsdr9MZMFs1f7q/lSA9paqE	false	tandem tag:?-?(MINT-8434895)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)