#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P49759	-	intact:EBI-473775|uniprotkb:Q8N5V8|uniprotkb:Q0P694|intact:EBI-2622912|uniprotkb:B4DFW7|ensembl:ENSP00000326830	-	psi-mi:clk1_human(display_long)|uniprotkb:CDC-like kinase 1(gene name synonym)|uniprotkb:CLK1(gene name)|psi-mi:CLK1(display_short)|uniprotkb:CLK(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Walte et al. (2013)	mint:MINT-8433592|mint:fj-13-0101|pubmed:23809146	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8538298|mint:MINT-8433639	-	-	psi-mi:"MI:0503"(self)	-	psi-mi:"MI:0503"(self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_004062.2|refseq:NP_001155879.1|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49759|rcsb pdb:1Z57|rcsb pdb:2VAG|rcsb pdb:5J1V|rcsb pdb:5J1W|rcsb pdb:5X8I|rcsb pdb:6FT8|rcsb pdb:6FT9|rcsb pdb:6FYO|rcsb pdb:6G33|rcsb pdb:6I5H|rcsb pdb:6I5I|rcsb pdb:6I5K|rcsb pdb:6I5L|rcsb pdb:6KHD|rcsb pdb:6Q8K|rcsb pdb:6Q8P|rcsb pdb:6QTY|rcsb pdb:6R3D|rcsb pdb:6R6E|rcsb pdb:6R6X|rcsb pdb:6R8J|rcsb pdb:6RAA|rcsb pdb:6TW2|rcsb pdb:6YTA|rcsb pdb:6YTD|rcsb pdb:6YTE|rcsb pdb:6YTG|rcsb pdb:6YTI|rcsb pdb:6Z4Z|rcsb pdb:6Z50|rcsb pdb:6ZLN|rcsb pdb:7AK3|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENSG00000013441(gene)|ensembl:ENST00000321356(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|mint:MINT-8433641(identity)	-	-	-	-	figure legend:f1b|comment:mint|intra-molecular:true	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/26	2014/10/16	rogid:HUyYLfLTfZHyTdtTNdbR/HPBloM9606	-	intact-crc:247C2696602A7536	false	tag:?-?(MINT-8433654)	-	-	-	psi-mi:"MI:0113"(western blot)	-
uniprotkb:Q9H2X6	-	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	-	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	-	psi-mi:"MI:0424"(protein kinase assay)	Walte et al. (2013)	mint:MINT-8433592|mint:fj-13-0101|pubmed:23809146	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8538272|mint:MINT-8433597	-	-	psi-mi:"MI:0503"(self)	-	psi-mi:"MI:0503"(self)	-	psi-mi:"MI:0326"(protein)	-	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N|mint:MINT-8433599(identity)	-	-	-	-	figure legend:f1b|comment:mint|intra-molecular:true	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/26	2014/10/16	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	-	intact-crc:C67AD0DA6F725C7B	false	tag:?-?(MINT-8433651)	-	-	-	psi-mi:"MI:0113"(western blot)	-
uniprotkb:Q63470	-	intact:EBI-7796229|ensembl:ENSRNOP00000042446|intact:MINT-2790195	-	psi-mi:dyr1a_rat(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:RP86(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Walte et al. (2013)	mint:MINT-8433592|mint:fj-13-0101|pubmed:23809146	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8538283|mint:MINT-8433628	-	-	psi-mi:"MI:0503"(self)	-	psi-mi:"MI:0503"(self)	-	psi-mi:"MI:0326"(protein)	-	refseq:XP_008766785.1|refseq:XP_008766786.1|refseq:XP_008766787.1|ensembl:ENSRNOG00000001662(gene)|ensembl:ENSRNOT00000050342(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q63470|reactome:R-RNO-1538133|rgd:2528|refseq:NP_036923.1|refseq:XP_006248093.1|mint:MINT-8433630(identity)	-	-	comment:mint|comment:homomint|function:May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates	-	comment:mint|figure legend:f1b f2b f3|intra-molecular:true	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/26	2014/10/16	rogid:A9JxUmJJEpow0xT2+Xp1A5hVGCQ10116	-	intact-crc:3CDB87ADCBE84A27	false	mutation disrupting interaction:188-188(MINT-8433646)|tag:?-?(MINT-8433633)	-	-	-	psi-mi:"MI:0113"(western blot)	-
uniprotkb:Q63470	uniprotkb:O75533	intact:EBI-7796229|ensembl:ENSRNOP00000042446|intact:MINT-2790195	intact:EBI-876542|ensembl:ENSP00000335321|uniprotkb:E9PCH3	psi-mi:dyr1a_rat(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:RP86(gene name synonym)	psi-mi:sf3b1_human(display_long)|uniprotkb:Pre-mRNA-splicing factor SF3b 155 kDa subunit(gene name synonym)|uniprotkb:Spliceosome-associated protein 155(gene name synonym)|uniprotkb:SF3B1(gene name)|psi-mi:SF3B1(display_short)|uniprotkb:SAP155(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Walte et al. (2013)	mint:MINT-8433592|mint:fj-13-0101|pubmed:23809146	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8538309|mint:MINT-8433657	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008766785.1|refseq:XP_008766786.1|refseq:XP_008766787.1|ensembl:ENSRNOG00000001662(gene)|ensembl:ENSRNOT00000050342(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q63470|reactome:R-RNO-1538133|rgd:2528|refseq:NP_036923.1|refseq:XP_006248093.1|mint:MINT-8433659(identity)	ensembl:ENSG00000115524(gene)|ensembl:ENST00000335508(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0034693"(U11/U12 snRNP)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015016(Splicing factor 3B subunit 1)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038737|mint:O75533|rcsb pdb:2F9D|rcsb pdb:2F9J|rcsb pdb:2FHO|rcsb pdb:2PEH|rcsb pdb:3LQV|rcsb pdb:4OZ1|rcsb pdb:5IFE|rcsb pdb:5O9Z|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:5ZYA|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6EN4|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6N3E|refseq:NP_036565.2|dip:DIP-29411N|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-5250924|reactome:R-HSA-72163|reactome:R-HSA-72165|mint:MINT-8433667(identity)	-	comment:mint|comment:homomint|function:May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates	-	figure legend:f4|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/26	2014/10/16	rogid:A9JxUmJJEpow0xT2+Xp1A5hVGCQ10116	rogid:2KqZNVdZoItavA0DFR3zZ16U0tI9606	intact-crc:69569AC069DDAE3A|rigid:+WB+CH8HnO3Qj2eRApIgzQASpPE	false	tag:?-?(MINT-8433662)	phosphorylated residue:434-434(MINT-8433671)|his tag:?-?(MINT-8433668)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)