#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P00533	uniprotkb:P29353	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sigismund et al. (2013)	pubmed:23799367|imex:IM-22228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8846810|imex:IM-22228-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N	-	-	-	figure legend:f4d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2013/11/08	2014/10/16	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	intact-crc:D812C2E2614F21B7|rigid:Z7rhHPINCLTzQytrxQn8qVVbxT4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62993	uniprotkb:P00533	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sigismund et al. (2013)	pubmed:23799367|imex:IM-22228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8846806|imex:IM-22228-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	-	-	-	figure legend:f4d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2013/11/08	2014/10/16	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	intact-crc:3B4A1A3D0C3C41FA|rigid:Llz17iihDf5Y9Ogfh1qj4UbJ4S8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P00533	uniprotkb:P22681	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sigismund et al. (2013)	pubmed:23799367|imex:IM-22228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8846783|imex:IM-22228-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377	-	-	-	figure legend:f4d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2013/11/08	2014/10/16	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:62EF50653B757CC9|rigid:eaGtuXjv4qDRv009jJkaGZmzaOs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01279	uniprotkb:P22682	intact:EBI-6296235|ensembl:ENSMUSP00000020329	intact:EBI-640919|intact:EBI-2642588|uniprotkb:Q3U527|ensembl:ENSMUSP00000146244|uniprotkb:Q8CEA1	psi-mi:egfr_mouse(display_long)|uniprotkb:Egfr(gene name)|psi-mi:Egfr(display_short)	psi-mi:cbl_mouse(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:Cbl(gene name)|psi-mi:Cbl(display_short)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sigismund et al. (2013)	pubmed:23799367|imex:IM-22228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8846800|imex:IM-22228-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020122(gene)|ensembl:ENSMUST00000020329(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016301"(kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043586"(tongue development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:Q01279|reactome:R-MMU-1227986|reactome:R-MMU-1236394|reactome:R-MMU-1250196|reactome:R-MMU-1257604|reactome:R-MMU-177929|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-1963642|reactome:R-MMU-212718|reactome:R-MMU-2179392|reactome:R-MMU-445144|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8857538|reactome:R-MMU-8863795|reactome:R-MMU-9009391|reactome:R-MMU-9013507|dip:DIP-5763N|refseq:NP_997538.1	interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22682|rcsb pdb:2D9S|reactome:R-MMU-1059683|reactome:R-MMU-1295596|reactome:R-MMU-1433559|reactome:R-MMU-182971|reactome:R-MMU-2173789|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6807004|reactome:R-MMU-8849469|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-912631|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR024162|reactome:R-MMU-9706369|ensembl:ENSMUSG00000034342(gene)|ensembl:ENSMUST00000206720(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|refseq:NP_031645.2|dip:DIP-33472N	-	-	-	figure legend:f7d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nr6wt)|taxid:10090(Mus musculus)	-	2013/11/08	2014/10/16	rogid:QpcGsHh+dM/fiIe1L/tEfxQTKGY10090	rogid:8MpthfXwJFMSMC6mDaTdb063dj010090	intact-crc:DD9C464DE2FFEE02|rigid:CzGUylCzZGaJNHGVO+YdxkbRQr0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01279	uniprotkb:Q60631	intact:EBI-6296235|ensembl:ENSMUSP00000020329	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:egfr_mouse(display_long)|uniprotkb:Egfr(gene name)|psi-mi:Egfr(display_short)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sigismund et al. (2013)	pubmed:23799367|imex:IM-22228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8846800|imex:IM-22228-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020122(gene)|ensembl:ENSMUST00000020329(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016301"(kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043586"(tongue development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:Q01279|reactome:R-MMU-1227986|reactome:R-MMU-1236394|reactome:R-MMU-1250196|reactome:R-MMU-1257604|reactome:R-MMU-177929|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-1963642|reactome:R-MMU-212718|reactome:R-MMU-2179392|reactome:R-MMU-445144|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8857538|reactome:R-MMU-8863795|reactome:R-MMU-9009391|reactome:R-MMU-9013507|dip:DIP-5763N|refseq:NP_997538.1	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	-	-	-	figure legend:f7d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nr6wt)|taxid:10090(Mus musculus)	-	2013/11/08	2014/10/16	rogid:QpcGsHh+dM/fiIe1L/tEfxQTKGY10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:DD9C464DE2FFEE02|rigid:CzGUylCzZGaJNHGVO+YdxkbRQr0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01279	uniprotkb:P22682	intact:EBI-6296235|ensembl:ENSMUSP00000020329	intact:EBI-640919|intact:EBI-2642588|uniprotkb:Q3U527|ensembl:ENSMUSP00000146244|uniprotkb:Q8CEA1	psi-mi:egfr_mouse(display_long)|uniprotkb:Egfr(gene name)|psi-mi:Egfr(display_short)	psi-mi:cbl_mouse(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:Cbl(gene name)|psi-mi:Cbl(display_short)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sigismund et al. (2013)	pubmed:23799367|imex:IM-22228	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8846787|imex:IM-22228-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020122(gene)|ensembl:ENSMUST00000020329(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016301"(kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043586"(tongue development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:Q01279|reactome:R-MMU-1227986|reactome:R-MMU-1236394|reactome:R-MMU-1250196|reactome:R-MMU-1257604|reactome:R-MMU-177929|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-1963642|reactome:R-MMU-212718|reactome:R-MMU-2179392|reactome:R-MMU-445144|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8857538|reactome:R-MMU-8863795|reactome:R-MMU-9009391|reactome:R-MMU-9013507|dip:DIP-5763N|refseq:NP_997538.1	interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22682|rcsb pdb:2D9S|reactome:R-MMU-1059683|reactome:R-MMU-1295596|reactome:R-MMU-1433559|reactome:R-MMU-182971|reactome:R-MMU-2173789|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6807004|reactome:R-MMU-8849469|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-912631|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR024162|reactome:R-MMU-9706369|ensembl:ENSMUSG00000034342(gene)|ensembl:ENSMUST00000206720(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|refseq:NP_031645.2|dip:DIP-33472N	-	-	-	figure legend:f8a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nr6wt)|taxid:10090(Mus musculus)	-	2013/11/08	2014/10/16	rogid:QpcGsHh+dM/fiIe1L/tEfxQTKGY10090	rogid:8MpthfXwJFMSMC6mDaTdb063dj010090	intact-crc:1DD8DBAC0227817B|rigid:R7U3Pd584cSPg5+L5GF+41vyhak	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P22681	uniprotkb:P62993	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0096"(pull down)	Sigismund et al. (2013)	pubmed:23799367|imex:IM-22228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8847802|imex:IM-22228-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	-	-	-	figure legend:f6d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/08	2014/10/16	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:5A93BCD0DA09AB7A|rigid:4GburTw/JEHbFrWAVlagDnRFyCw	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0113"(western blot)
uniprotkb:P22681	uniprotkb:P00533	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Sigismund et al. (2013)	pubmed:23799367|imex:IM-22228	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8847802|imex:IM-22228-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	-	-	-	figure legend:f6d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/08	2014/10/16	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	intact-crc:5A93BCD0DA09AB7A|rigid:4GburTw/JEHbFrWAVlagDnRFyCw	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0113"(western blot)