#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y2L1	uniprotkb:Q01780	intact:EBI-373539|uniprotkb:A6NI21|uniprotkb:Q5W0P7|uniprotkb:Q5W0P8|uniprotkb:Q658Z7|uniprotkb:Q7Z481|uniprotkb:Q8WWI2|uniprotkb:Q9UG36|uniprotkb:B2RBL2|ensembl:ENSP00000366997	intact:EBI-358236|uniprotkb:B1AKQ1|uniprotkb:Q15158|uniprotkb:B1AKQ0|intact:EBI-28973393|ensembl:ENSP00000366135	psi-mi:rrp44_human(display_long)|uniprotkb:DIS3(gene name)|psi-mi:DIS3(display_short)|uniprotkb:Ribosomal RNA-processing protein 44(gene name synonym)|uniprotkb:Protein DIS3 homolog(gene name synonym)|uniprotkb:KIAA1008(gene name synonym)|uniprotkb:RRP44(gene name synonym)	psi-mi:exosx_human(display_long)|uniprotkb:PMSCL2(gene name synonym)|uniprotkb:EXOSC10(gene name)|psi-mi:EXOSC10(display_short)|uniprotkb:PMSCL(gene name synonym)|uniprotkb:Polymyositis/scleroderma autoantigen 2(gene name synonym)|uniprotkb:Autoantigen PM/Scl 2(gene name synonym)|uniprotkb:Polymyositis/scleroderma autoantigen 100 kDa(gene name synonym)|uniprotkb:P100 polymyositis-scleroderma overlap syndrome-associated autoantigen(gene name synonym)|uniprotkb:RRP6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubas et al. (2013)	pubmed:23756462|imex:IM-21687	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8845744|imex:IM-21687-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121698.1|refseq:NP_055768.3|ensembl:ENSG00000083520(gene)|ensembl:ENST00000377767(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0071034"(CUT catabolic process)|interpro:IPR001900(Ribonuclease II and R)|interpro:IPR002716(PilT protein, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022966|interpro:IPR029060|interpro:IPR033770|interpro:IPR033771|interpro:IPR041505|mint:Q9Y2L1|rcsb pdb:6D6Q|rcsb pdb:6D6R|rcsb pdb:6H25|reactome:R-HSA-380994|reactome:R-HSA-429958|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604|reactome:R-HSA-6791226	ensembl:ENST00000304457|ensembl:ENSP00000307307|ensembl:ENSP00000366135|refseq:NP_001001998.1|refseq:NP_002676.1|dip:DIP-31249N|ensembl:ENSG00000171824(gene)|ensembl:ENST00000376936(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0071038"(nuclear polyadenylation-dependent tRNA catabolic process)|go:"GO:0071039"(nuclear polyadenylation-dependent CUT catabolic process)|go:"GO:0071040"(nuclear polyadenylation-dependent antisense transcript catabolic process)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071048"|go:"GO:0071051"(polyadenylation-dependent snoRNA 3'-end processing)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002562(3'-5' exonuclease)|go:"GO:0016020"(membrane)|interpro:IPR010997(HRDC-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012588(Exosome-associated factor Rrp6, N-terminal)|interpro:IPR036397|mint:Q01780|rcsb pdb:2CPR|rcsb pdb:3SAF|rcsb pdb:3SAG|rcsb pdb:3SAH|rcsb pdb:6D6Q|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0035327"|rcsb pdb:6D6R|reactome:R-HSA-6791226|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071034"(CUT catabolic process)|go:"GO:0071035"(nuclear polyadenylation-dependent rRNA catabolic process)|go:"GO:0071036"(nuclear polyadenylation-dependent snoRNA catabolic process)|go:"GO:0071037"(nuclear polyadenylation-dependent snRNA catabolic process)	-	-	-	figure legend:f1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2013/11/07	2014/10/16	rogid:cHOcZh1JkvywNK4Tq2DUvPMm6kc9606	rogid:JeBuVE3nYxlFwYt/xUGlIC6ANJo9606	intact-crc:4AB509CA282D0E3E|rigid:MWCHaE1t3XiJb9zfTuij8NeOAvA	false	flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2L1	uniprotkb:Q9Y2L1	intact:EBI-373539|uniprotkb:A6NI21|uniprotkb:Q5W0P7|uniprotkb:Q5W0P8|uniprotkb:Q658Z7|uniprotkb:Q7Z481|uniprotkb:Q8WWI2|uniprotkb:Q9UG36|uniprotkb:B2RBL2|ensembl:ENSP00000366997	intact:EBI-373539|uniprotkb:A6NI21|uniprotkb:Q5W0P7|uniprotkb:Q5W0P8|uniprotkb:Q658Z7|uniprotkb:Q7Z481|uniprotkb:Q8WWI2|uniprotkb:Q9UG36|uniprotkb:B2RBL2|ensembl:ENSP00000366997	psi-mi:rrp44_human(display_long)|uniprotkb:DIS3(gene name)|psi-mi:DIS3(display_short)|uniprotkb:Ribosomal RNA-processing protein 44(gene name synonym)|uniprotkb:Protein DIS3 homolog(gene name synonym)|uniprotkb:KIAA1008(gene name synonym)|uniprotkb:RRP44(gene name synonym)	psi-mi:rrp44_human(display_long)|uniprotkb:DIS3(gene name)|psi-mi:DIS3(display_short)|uniprotkb:Ribosomal RNA-processing protein 44(gene name synonym)|uniprotkb:Protein DIS3 homolog(gene name synonym)|uniprotkb:KIAA1008(gene name synonym)|uniprotkb:RRP44(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubas et al. (2013)	pubmed:23756462|imex:IM-21687	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8845744|imex:IM-21687-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121698.1|refseq:NP_055768.3|ensembl:ENSG00000083520(gene)|ensembl:ENST00000377767(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0071034"(CUT catabolic process)|interpro:IPR001900(Ribonuclease II and R)|interpro:IPR002716(PilT protein, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022966|interpro:IPR029060|interpro:IPR033770|interpro:IPR033771|interpro:IPR041505|mint:Q9Y2L1|rcsb pdb:6D6Q|rcsb pdb:6D6R|rcsb pdb:6H25|reactome:R-HSA-380994|reactome:R-HSA-429958|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604|reactome:R-HSA-6791226	refseq:NP_001121698.1|refseq:NP_055768.3|ensembl:ENSG00000083520(gene)|ensembl:ENST00000377767(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0071034"(CUT catabolic process)|interpro:IPR001900(Ribonuclease II and R)|interpro:IPR002716(PilT protein, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022966|interpro:IPR029060|interpro:IPR033770|interpro:IPR033771|interpro:IPR041505|mint:Q9Y2L1|rcsb pdb:6D6Q|rcsb pdb:6D6R|rcsb pdb:6H25|reactome:R-HSA-380994|reactome:R-HSA-429958|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604|reactome:R-HSA-6791226	-	-	-	figure legend:f1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2013/11/07	2014/10/16	rogid:cHOcZh1JkvywNK4Tq2DUvPMm6kc9606	rogid:cHOcZh1JkvywNK4Tq2DUvPMm6kc9606	intact-crc:4AB509CA282D0E3E|rigid:MWCHaE1t3XiJb9zfTuij8NeOAvA	false	flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TF46	uniprotkb:Q9NQT5	intact:EBI-3672244|uniprotkb:Q8N1N8|uniprotkb:Q8WTU9|uniprotkb:Q96CM7|ensembl:ENSP00000321711	intact:EBI-371866|uniprotkb:Q5QP85|uniprotkb:Q9Y3A8|ensembl:ENSP00000323046|uniprotkb:A8K0K6	psi-mi:di3l1_human(display_long)|uniprotkb:DIS3L1(gene name synonym)|uniprotkb:DIS3L(gene name)|psi-mi:DIS3L(display_short)|uniprotkb:KIAA1955(gene name synonym)	psi-mi:exos3_human(display_long)|uniprotkb:EXOSC3(gene name)|psi-mi:EXOSC3(display_short)|uniprotkb:RRP40(gene name synonym)|uniprotkb:CGI-102(orf name)|uniprotkb:Ribosomal RNA-processing protein 40(gene name synonym)|uniprotkb:Exosome component 3(gene name synonym)|uniprotkb:p10(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lubas et al. (2013)	pubmed:23756462|imex:IM-21687	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8845760|imex:IM-21687-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137160.1|refseq:NP_588616.1|refseq:NP_001310865.1|refseq:NP_001310867.1|refseq:NP_001310868.1|refseq:NP_001310870.1|refseq:NP_001310874.1|refseq:NP_001310875.1|ensembl:ENSG00000166938(gene)|ensembl:ENST00000319212(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0003723"(RNA binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0019899"(enzyme binding)|interpro:IPR001900(Ribonuclease II and R)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022966|interpro:IPR031192|interpro:IPR033770|interpro:IPR033771|interpro:IPR041505|mint:Q8TF46	refseq:NP_001002269.1|refseq:NP_057126.2|ensembl:ENSG00000107371(gene)|ensembl:ENST00000327304(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0034475"(U4 snRNA 3'-end processing)|go:"GO:0035327"|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0045006"(DNA deamination)|go:"GO:0045190"(isotype switching)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0071034"(CUT catabolic process)|go:"GO:0071035"(nuclear polyadenylation-dependent rRNA catabolic process)|go:"GO:0071038"(nuclear polyadenylation-dependent tRNA catabolic process)|go:"GO:0071049"|go:"GO:0071051"(polyadenylation-dependent snoRNA 3'-end processing)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR026699|interpro:IPR036612|interpro:IPR037319|mint:Q9NQT5|rcsb pdb:2NN6|rcsb pdb:6D6Q|rcsb pdb:6D6R|rcsb pdb:6H25|reactome:R-HSA-380994|reactome:R-HSA-429958|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604|reactome:R-HSA-6791226|dip:DIP-29847N	-	-	-	figure legend:f1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2013/11/07	2014/10/16	rogid:rxO2GoLqsuS4+/zLJsqCU8LFQyw9606	rogid:ZyFFgoy7HM3oZ35I16XAH3jCook9606	intact-crc:A2C5FF4B331ECEC0|rigid:3rwpyFJXhm6OTw0deYULbwtt5is	false	flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)