#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9NRW1 uniprotkb:Q02410-1 intact:EBI-1760079|uniprotkb:D3DND3|uniprotkb:B2R5Z9|uniprotkb:Q92929|uniprotkb:B7Z337|ensembl:ENSP00000285208|ensembl:ENSP00000437797 intact:EBI-9247467|ensembl:ENSP00000265381 psi-mi:rab6b_human(display_long)|uniprotkb:RAB6B(gene name)|psi-mi:RAB6B(display_short) psi-mi:q02410-1(display_long)|uniprotkb:APBA1(gene name)|psi-mi:APBA1(display_short)|uniprotkb:MINT1(gene name synonym)|uniprotkb:X11(gene name synonym)|uniprotkb:Adapter protein X11alpha(gene name synonym)|uniprotkb:Neuron-specific X11 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Thyrock et al. (2013) pubmed:23737971|imex:IM-21673 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-8840307 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011511195.1|refseq:NP_057661.3|ensembl:ENSG00000154917(gene)|ensembl:ENST00000285208(transcript)|ensembl:ENST00000543906(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0098793"(presynapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q9NRW1|rcsb pdb:2E9S|rcsb pdb:2FE4|rcsb pdb:2FFQ|reactome:R-HSA-6811436|reactome:R-HSA-6811440|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198 intact:EBI-368690(isoform-parent)|ensembl:ENSG00000107282(gene)|ensembl:ENST00000265381(transcript) intact:EBI-8840227(see-also) - - figure legend:TABLE 2 and 4|negative:The interaction does not occur under these experimental conditions.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2013/10/31 2014/10/16 rogid:GmhjkLknjr8fxoUBxNx5ak5S/hQ9606 rogid:Ntj/7mc+ATzi5O4lwhKsEl920BA9606 intact-crc:006037DC37F8772E|rigid:r6QFdf8tRP+1cVUgjGcoAkMT21o true mutation:72-72|mutation:27-27 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q02410-1 uniprotkb:P20340-1 intact:EBI-9247467|ensembl:ENSP00000265381 intact:EBI-8851226|ensembl:ENSP00000336850 psi-mi:q02410-1(display_long)|uniprotkb:APBA1(gene name)|psi-mi:APBA1(display_short)|uniprotkb:MINT1(gene name synonym)|uniprotkb:X11(gene name synonym)|uniprotkb:Adapter protein X11alpha(gene name synonym)|uniprotkb:Neuron-specific X11 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 1(gene name synonym) psi-mi:p20340-1(display_long)|uniprotkb:Rab-6a(isoform synonym)|uniprotkb:RAB6A(gene name)|psi-mi:RAB6A(display_short)|uniprotkb:RAB6(gene name synonym) psi-mi:"MI:0018"(two hybrid) Thyrock et al. (2013) pubmed:23737971|imex:IM-21673 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-8840304 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-368690(isoform-parent)|ensembl:ENSG00000107282(gene)|ensembl:ENST00000265381(transcript) intact:EBI-1052826(isoform-parent)|ensembl:ENST00000336083(transcript)|ensembl:ENSG00000175582(gene) intact:EBI-8840230(see-also) - - figure legend:TABLE 2 and 4|negative:The interaction does not occur under these experimental conditions.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2013/10/31 2014/10/16 rogid:Ntj/7mc+ATzi5O4lwhKsEl920BA9606 rogid:VtLF/2T3LuVttzSCftP/mnAxyLk9606 intact-crc:A169B4D7617BF380|rigid:tsCS14thgI9u+0o7DOiF3/DJZfk true - mutation:72-72|mutation:27-27 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NRW1 uniprotkb:Q02410-1 intact:EBI-1760079|uniprotkb:D3DND3|uniprotkb:B2R5Z9|uniprotkb:Q92929|uniprotkb:B7Z337|ensembl:ENSP00000285208|ensembl:ENSP00000437797 intact:EBI-9247467|ensembl:ENSP00000265381 psi-mi:rab6b_human(display_long)|uniprotkb:RAB6B(gene name)|psi-mi:RAB6B(display_short) psi-mi:q02410-1(display_long)|uniprotkb:APBA1(gene name)|psi-mi:APBA1(display_short)|uniprotkb:MINT1(gene name synonym)|uniprotkb:X11(gene name synonym)|uniprotkb:Adapter protein X11alpha(gene name synonym)|uniprotkb:Neuron-specific X11 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Thyrock et al. (2013) pubmed:23737971|imex:IM-21673 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-8840419 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011511195.1|refseq:NP_057661.3|ensembl:ENSG00000154917(gene)|ensembl:ENST00000285208(transcript)|ensembl:ENST00000543906(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0098793"(presynapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q9NRW1|rcsb pdb:2E9S|rcsb pdb:2FE4|rcsb pdb:2FFQ|reactome:R-HSA-6811436|reactome:R-HSA-6811440|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198 intact:EBI-368690(isoform-parent)|ensembl:ENSG00000107282(gene)|ensembl:ENST00000265381(transcript) intact:EBI-8840370(see-also) - - figure legend:Fig 2A|negative:This interaction does not occur under these experimental conditions.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/31 2014/10/16 rogid:GmhjkLknjr8fxoUBxNx5ak5S/hQ9606 rogid:Ntj/7mc+ATzi5O4lwhKsEl920BA9606 intact-crc:4B315EF9DCDC1530|rigid:r6QFdf8tRP+1cVUgjGcoAkMT21o true mutation disrupting interaction:27-27|mutation:72-72|green fluorescent protein tag:?-? glutathione s tranferase tag:n-n|binding-associated region:438-625(IPR006020) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P20340 uniprotkb:Q02410-1 intact:EBI-1052826|uniprotkb:Q5U0A8|uniprotkb:Q9UBE4|uniprotkb:A8K133|uniprotkb:Q1W5D8|uniprotkb:B7Z772|uniprotkb:F5H668|ensembl:ENSP00000336850 intact:EBI-9247467|ensembl:ENSP00000265381 psi-mi:rab6a_human(display_long)|uniprotkb:RAB6A(gene name)|psi-mi:RAB6A(display_short)|uniprotkb:RAB6(gene name synonym) psi-mi:q02410-1(display_long)|uniprotkb:APBA1(gene name)|psi-mi:APBA1(display_short)|uniprotkb:MINT1(gene name synonym)|uniprotkb:X11(gene name synonym)|uniprotkb:Adapter protein X11alpha(gene name synonym)|uniprotkb:Neuron-specific X11 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Thyrock et al. (2013) pubmed:23737971|imex:IM-21673 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-8840423 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002860.2|refseq:NP_942599.1|refseq:NP_001230648.1|refseq:NP_001230647.1|ensembl:ENSG00000175582(gene)|ensembl:ENST00000336083(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072385"(minus-end-directed organelle transport along microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20340|rcsb pdb:1YZQ|rcsb pdb:2GIL|rcsb pdb:3BBP|rcsb pdb:3CWZ|rcsb pdb:4DKX|rcsb pdb:5LEF|reactome:R-HSA-1912420|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-6811440|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-39668N intact:EBI-368690(isoform-parent)|ensembl:ENSG00000107282(gene)|ensembl:ENST00000265381(transcript) intact:EBI-8840382(see-also) - - figure legend:Fig 2A|negative:This interaction does not occur under these experimental conditions.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/10/31 2014/10/16 rogid:VtLF/2T3LuVttzSCftP/mnAxyLk9606 rogid:Ntj/7mc+ATzi5O4lwhKsEl920BA9606 intact-crc:46D70F06857FB60E|rigid:tsCS14thgI9u+0o7DOiF3/DJZfk true cyan fluorescent protein tag:?-?|mutation disrupting interaction:27-27|mutation:72-72 glutathione s tranferase tag:n-n|binding-associated region:438-625(IPR006020) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q02410-1 uniprotkb:P20340-1 intact:EBI-9247467|ensembl:ENSP00000265381 intact:EBI-8851226|ensembl:ENSP00000336850 psi-mi:q02410-1(display_long)|uniprotkb:APBA1(gene name)|psi-mi:APBA1(display_short)|uniprotkb:MINT1(gene name synonym)|uniprotkb:X11(gene name synonym)|uniprotkb:Adapter protein X11alpha(gene name synonym)|uniprotkb:Neuron-specific X11 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 1(gene name synonym) psi-mi:p20340-1(display_long)|uniprotkb:Rab-6a(isoform synonym)|uniprotkb:RAB6A(gene name)|psi-mi:RAB6A(display_short)|uniprotkb:RAB6(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Thyrock et al. (2013) pubmed:23737971|imex:IM-21673 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-8840574 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-368690(isoform-parent)|ensembl:ENSG00000107282(gene)|ensembl:ENST00000265381(transcript) intact:EBI-1052826(isoform-parent)|ensembl:ENST00000336083(transcript)|ensembl:ENSG00000175582(gene) intact:EBI-8840525(see-also) - - figure legend:Fig 3|negative:The interaction does not occur under these experimental conditions.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/10/31 2014/10/16 rogid:Ntj/7mc+ATzi5O4lwhKsEl920BA9606 rogid:VtLF/2T3LuVttzSCftP/mnAxyLk9606 intact-crc:8531DB2DD5362DD9|rigid:tsCS14thgI9u+0o7DOiF3/DJZfk true sufficient binding region:438-625(IPR006020)|enhanced yellow fluorescent protein tag:n-n cyan fluorescent protein tag:c-c|mutation:72-72 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q02410-1 uniprotkb:Q9NRW1 intact:EBI-9247467|ensembl:ENSP00000265381 intact:EBI-1760079|uniprotkb:D3DND3|uniprotkb:B2R5Z9|uniprotkb:Q92929|uniprotkb:B7Z337|ensembl:ENSP00000285208|ensembl:ENSP00000437797 psi-mi:q02410-1(display_long)|uniprotkb:APBA1(gene name)|psi-mi:APBA1(display_short)|uniprotkb:MINT1(gene name synonym)|uniprotkb:X11(gene name synonym)|uniprotkb:Adapter protein X11alpha(gene name synonym)|uniprotkb:Neuron-specific X11 protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 1(gene name synonym) psi-mi:rab6b_human(display_long)|uniprotkb:RAB6B(gene name)|psi-mi:RAB6B(display_short) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Thyrock et al. (2013) pubmed:23737971|imex:IM-21673 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-8840571 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-368690(isoform-parent)|ensembl:ENSG00000107282(gene)|ensembl:ENST00000265381(transcript) refseq:XP_011511195.1|refseq:NP_057661.3|ensembl:ENSG00000154917(gene)|ensembl:ENST00000285208(transcript)|ensembl:ENST00000543906(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0098793"(presynapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q9NRW1|rcsb pdb:2E9S|rcsb pdb:2FE4|rcsb pdb:2FFQ|reactome:R-HSA-6811436|reactome:R-HSA-6811440|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198 intact:EBI-8840541(see-also) - - figure legend:Fig 3|negative:The interaction does not occur under these experimental conditions.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/10/31 2014/10/16 rogid:Ntj/7mc+ATzi5O4lwhKsEl920BA9606 rogid:GmhjkLknjr8fxoUBxNx5ak5S/hQ9606 intact-crc:F43E6813A0392304|rigid:r6QFdf8tRP+1cVUgjGcoAkMT21o true enhanced yellow fluorescent protein tag:n-n|sufficient binding region:438-625(IPR006020) cyan fluorescent protein tag:c-c|mutation:72-72 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)