#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9JMB7	uniprotkb:Q80VL1	intact:EBI-8573121|ensembl:ENSMUSP00000083222|intact:UNK-5550589|uniprotkb:A1L325|uniprotkb:A1L324|uniprotkb:Q6NXX0	intact:EBI-8843081|ensembl:ENSMUSP00000041002|ensembl:ENSMUSP00000129635|ensembl:ENSMUSP00000142561	psi-mi:piwl1_mouse(display_long)|uniprotkb:Piwil1(gene name)|psi-mi:Piwil1(display_short)|uniprotkb:Miwi(gene name synonym)	psi-mi:tdrkh_mouse(display_long)|uniprotkb:Tdrkh(gene name)|psi-mi:Tdrkh(display_short)|uniprotkb:Tdrd2(gene name synonym)|uniprotkb:Tudor domain-containing protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Saxe et al. (2013)	imex:IM-21677|pubmed:23714778	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8843074|imex:IM-21677-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006504381.1|ensembl:ENSMUSG00000029423(gene)|ensembl:ENSMUST00000086056(transcript)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0043186"(P granule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0097433"(dense body)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1905538"(polysome binding)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR031320|interpro:IPR031326|interpro:IPR036085|interpro:IPR036397|mint:Q9JMB7|rcsb pdb:2XFM|rcsb pdb:4P1Z|refseq:NP_067286.1|dip:DIP-59456N	refseq:XP_017175235.1|refseq:NP_082583.1|refseq:XP_006502201.1|ensembl:ENSMUSG00000041912(gene)|ensembl:ENSMUST00000045245(transcript)|ensembl:ENSMUST00000166032(transcript)|ensembl:ENSMUST00000197901(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0071546"(pi-body)|go:"GO:0071547"(piP-body)|interpro:IPR002999(Tudor)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR035437|interpro:IPR036612|mint:Q80VL1|rcsb pdb:1WE8	-	comment:mint|function:"Probable component of some RISC complex (RNA-induced silencing), which plays a role in spermatogenesis and in germ cell production, proliferation and maintenance. RISC complexes mediate RNA cleavage and translational silencing. Overexpression may cause malignant germline development. May be associated with proliferating activity of cancer cells. When suppressed, inhibits the growth of gastric cancer cells and induced cell cycle arrest in G2/M phase. Inhibits endoribonuclease DICER1 activity"	-	figure legend:f1c f1d|comment:"In adult testes, Tdrkh  and Miwi reciprocally co-immunoprecipitated each other (Figure 1C and D), but no in vivo interaction between Mili  and Tdrkh was noted (Figure 1C). Furthermore, Tdrkh and  Miwi2 co-localize in pre-natal testes (Supplementary  Figure 3h). Thus, Tdrkh specifically interacts with Miwi  and Miwi2."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis)	-	2013/11/05	2014/10/16	rogid:WuQtdXXnFsLsc0HQKeK7k5wPa0I10090	rogid:J6cxY3q2Mel0+nKDVLjEbgS6PVo10090	intact-crc:AFFDC75D63D226FC|rigid:vAJRfciZ9kon92LdaVLxvGuok9Q	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CDG1	uniprotkb:Q9JMB7	intact:EBI-8573412|ensembl:ENSMUSP00000047385|uniprotkb:A6H617|uniprotkb:Q3TQE8|uniprotkb:Q99MV6|uniprotkb:Q9JMB6|intact:MINT-8174116	intact:EBI-8573121|ensembl:ENSMUSP00000083222|intact:UNK-5550589|uniprotkb:A1L325|uniprotkb:A1L324|uniprotkb:Q6NXX0	psi-mi:piwl2_mouse(display_long)|uniprotkb:Piwil2(gene name)|psi-mi:Piwil2(display_short)|uniprotkb:Mili(gene name synonym)	psi-mi:piwl1_mouse(display_long)|uniprotkb:Piwil1(gene name)|psi-mi:Piwil1(display_short)|uniprotkb:Miwi(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Saxe et al. (2013)	imex:IM-21677|pubmed:23714778	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8843109|imex:IM-21677-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000033644(gene)|ensembl:ENSMUST00000048129(transcript)|go:"GO:0000966"(RNA 5'-end processing)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010370"(perinucleolar chromocenter)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048477"(oogenesis)|go:"GO:0048511"(rhythmic process)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060903"(positive regulation of meiosis I)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|go:"GO:0071546"(pi-body)|go:"GO:0097433"(dense body)|go:"GO:1905538"(polysome binding)|go:"GO:1990511"(piRNA biosynthetic process)|go:"GO:1990923"(PET complex)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR036085|interpro:IPR036397|mint:Q8CDG1|rcsb pdb:4B9W|refseq:XP_006519392.1|refseq:NP_067283.1|dip:DIP-48522N	refseq:XP_006504381.1|ensembl:ENSMUSG00000029423(gene)|ensembl:ENSMUST00000086056(transcript)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0043186"(P granule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0097433"(dense body)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1905538"(polysome binding)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR031320|interpro:IPR031326|interpro:IPR036085|interpro:IPR036397|mint:Q9JMB7|rcsb pdb:2XFM|rcsb pdb:4P1Z|refseq:NP_067286.1|dip:DIP-59456N	-	comment:mint	comment:mint|function:"Probable component of some RISC complex (RNA-induced silencing), which plays a role in spermatogenesis and in germ cell production, proliferation and maintenance. RISC complexes mediate RNA cleavage and translational silencing. Overexpression may cause malignant germline development. May be associated with proliferating activity of cancer cells. When suppressed, inhibits the growth of gastric cancer cells and induced cell cycle arrest in G2/M phase. Inhibits endoribonuclease DICER1 activity"	figure legend:f1c|comment:"In adult testes, Tdrkh  and Miwi reciprocally co-immunoprecipitated each other (Figure 1C and D), but no in vivo interaction between Mili  and Tdrkh was noted (Figure 1C). Furthermore, Tdrkh and  Miwi2 co-localize in pre-natal testes (Supplementary  Figure 3h). Thus, Tdrkh specifically interacts with Miwi  and Miwi2."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis)	-	2013/11/05	2014/10/16	rogid:bO1VWhO+PymJKboyEuEtKNueXpk10090	rogid:WuQtdXXnFsLsc0HQKeK7k5wPa0I10090	intact-crc:E09FB9EE5F55AFEC|rigid:lcK9FAqYlMokXxisCK4jRisQy1E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)