#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P10833	uniprotkb:O35904	intact:EBI-8351107|intact:MINT-4133129|ensembl:ENSMUSP00000042150	intact:EBI-647932|uniprotkb:Q8CJ28|ensembl:ENSMUSP00000101314	psi-mi:rras_mouse(display_long)|uniprotkb:Rras(gene name)|psi-mi:Rras(display_short)|uniprotkb:p23(gene name synonym)	psi-mi:pk3cd_mouse(display_long)|uniprotkb:Pik3cd(gene name)|psi-mi:Pik3cd(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8764103|imex:IM-21415-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033127.1|ensembl:ENSMUSG00000038387(gene)|ensembl:ENSMUST00000044111(transcript)|go:"GO:0002521"(leukocyte differentiation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0019003"(GDP binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060325"(face morphogenesis)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P10833|reactome:R-MMU-416550	refseq:NP_001157524.1|refseq:XP_006538715.1|dip:DIP-39841N|ensembl:ENSMUSG00000039936(gene)|ensembl:ENSMUST00000105689(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:1905278"(positive regulation of epithelial tube formation)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037703|interpro:IPR042236|rcsb pdb:2WXF|rcsb pdb:2WXG|rcsb pdb:2WXH|rcsb pdb:2WXI|rcsb pdb:2WXJ|rcsb pdb:2WXK|rcsb pdb:2WXL|rcsb pdb:2WXM|rcsb pdb:2WXN|rcsb pdb:2WXO|rcsb pdb:2WXP|rcsb pdb:2WXQ|rcsb pdb:2WXR|rcsb pdb:2X38|rcsb pdb:4AJW|rcsb pdb:4V0I|rcsb pdb:4XE0|rcsb pdb:5AE8|rcsb pdb:5AE9|rcsb pdb:5I4U|rcsb pdb:5I6U|rcsb pdb:5IS5|rcsb pdb:5L72|rcsb pdb:5NCY|rcsb pdb:5NCZ|rcsb pdb:5NGB|rcsb pdb:5O83|rcsb pdb:5T27|rcsb pdb:5T28|rcsb pdb:5T2B|rcsb pdb:5T2D|rcsb pdb:5T2G|rcsb pdb:5T2I|rcsb pdb:5T2L|rcsb pdb:5T2M|rcsb pdb:5T7F|rcsb pdb:5T8I|rcsb pdb:6DGT|rcsb pdb:6EYZ|rcsb pdb:6EZ6|rcsb pdb:6GY0|rcsb pdb:6HI9|rcsb pdb:6MUL|rcsb pdb:6MUM|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-512988|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-983695	-	comment:mint|function:Regulates the organization of the actin cytoskeleton	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 2A, Supp Fig. 1D,|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:zsmDFKVvmh8JuGUJr0bb6+BZ1Q010090	rogid:mcGmhHve+Mi2DhcQ7akqBFC0OfI10090	intact-crc:5913DA4080E297BB|rigid:5QixX0fEuo6XmvoPbMlVeuEVAAo	false	glutathione s tranferase tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O08989	uniprotkb:P42337	intact:EBI-772057|ensembl:ENSMUSP00000035045|ensembl:ENSMUSP00000112407|ensembl:ENSMUSP00000113275	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	psi-mi:rasm_mouse(display_long)|uniprotkb:Ras-related protein R-Ras3(gene name synonym)|uniprotkb:Muscle and microspikes Ras(gene name synonym)|uniprotkb:X-Ras(gene name synonym)|uniprotkb:Mras(gene name)|psi-mi:Mras(display_short)|uniprotkb:Xras(gene name synonym)	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8763861|imex:IM-21415-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032650.1|refseq:XP_006510888.1|ensembl:ENSMUSG00000032470(gene)|ensembl:ENSMUST00000035045(transcript)|ensembl:ENSMUST00000119472(transcript)|ensembl:ENSMUST00000122384(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0019003"(GDP binding)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|rcsb pdb:1X1R|rcsb pdb:1X1S|rcsb pdb:3KKO|rcsb pdb:3KKP|rcsb pdb:3KKQ|rcsb pdb:3PIR|rcsb pdb:3PIT|reactome:R-MMU-5673000	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	-	-	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 2A, Supp Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:GqkJG84Xmc4nFJ2uqJq67qtewwM10090	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	intact-crc:21C5E9668DCE9CC0|rigid:IX9RatjY5NiFKqlIG/qqCh6lT9M	false	glutathione s tranferase tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9JHG7	uniprotkb:Q61411	intact:EBI-644372|uniprotkb:Q80V09|ensembl:ENSMUSP00000062864|ensembl:ENSMUSP00000082596|ensembl:ENSMUSP00000123539|ensembl:ENSMUSP00000151400	intact:EBI-400273|uniprotkb:Q80WD2|uniprotkb:Q6P716|uniprotkb:Q811B9|ensembl:ENSMUSP00000026572|ensembl:ENSMUSP00000095570|uniprotkb:F7BIB2	psi-mi:pk3cg_mouse(display_long)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Pik3cg(gene name)|psi-mi:Pik3cg(display_short)|uniprotkb:Pi3kg1(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:rash_mouse(display_long)|uniprotkb:Hras(gene name)|psi-mi:Hras(display_short)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:Hras1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:p21ras(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8763917|imex:IM-21415-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139672.1|refseq:NP_001139673.1|refseq:NP_064668.2|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|ensembl:ENSMUSG00000020573(gene)|ensembl:ENSMUST00000053215(transcript)|ensembl:ENSMUST00000085469(transcript)|ensembl:ENSMUST00000156904(transcript)|ensembl:ENSMUST00000220366(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0032252"(secretory granule localization)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|reactome:R-MMU-9027276|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|refseq:XP_006515175.1|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|dip:DIP-41862N	refseq:NP_001123915.1|refseq:NP_001123916.1|refseq:NP_032310.2|ensembl:ENSMUSG00000025499(gene)|ensembl:ENSMUST00000026572(transcript)|ensembl:ENSMUST00000097957(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:Q61411|rcsb pdb:6KYH|reactome:R-MMU-1169092|reactome:R-MMU-1250347|reactome:R-MMU-1433557|reactome:R-MMU-171007|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-1963640|go:"GO:1900029"(positive regulation of ruffle assembly)|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-375165|reactome:R-MMU-3928662|reactome:R-MMU-5218921|reactome:R-MMU-5621575|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5658442|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-8849471|reactome:R-MMU-8851805|reactome:R-MMU-9607240|reactome:R-MMU-9634635|reactome:R-MMU-9648002|refseq:XP_006536222.2|dip:DIP-29361N	-	-	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 2A, Supp Fig. 1D,|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:SV/AI6H65Utm5ENkfXkXQ4lqaao10090	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw10090	intact-crc:57BB15E5FF12C3FB|rigid:Hc8B1bl/oP3oGneyH3IBztH5hjY	false	flag tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P10833	uniprotkb:Q9JHG7	intact:EBI-8351107|intact:MINT-4133129|ensembl:ENSMUSP00000042150	intact:EBI-644372|uniprotkb:Q80V09|ensembl:ENSMUSP00000062864|ensembl:ENSMUSP00000082596|ensembl:ENSMUSP00000123539|ensembl:ENSMUSP00000151400	psi-mi:rras_mouse(display_long)|uniprotkb:Rras(gene name)|psi-mi:Rras(display_short)|uniprotkb:p23(gene name synonym)	psi-mi:pk3cg_mouse(display_long)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Pik3cg(gene name)|psi-mi:Pik3cg(display_short)|uniprotkb:Pi3kg1(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8763994|imex:IM-21415-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033127.1|ensembl:ENSMUSG00000038387(gene)|ensembl:ENSMUST00000044111(transcript)|go:"GO:0002521"(leukocyte differentiation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0019003"(GDP binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060325"(face morphogenesis)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P10833|reactome:R-MMU-416550	refseq:NP_001139672.1|refseq:NP_001139673.1|refseq:NP_064668.2|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|ensembl:ENSMUSG00000020573(gene)|ensembl:ENSMUST00000053215(transcript)|ensembl:ENSMUST00000085469(transcript)|ensembl:ENSMUST00000156904(transcript)|ensembl:ENSMUST00000220366(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0032252"(secretory granule localization)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|reactome:R-MMU-9027276|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|refseq:XP_006515175.1|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|dip:DIP-41862N	-	comment:mint|function:Regulates the organization of the actin cytoskeleton	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 2A, Supp Fig. 1D,|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:zsmDFKVvmh8JuGUJr0bb6+BZ1Q010090	rogid:SV/AI6H65Utm5ENkfXkXQ4lqaao10090	intact-crc:51505D6D249729D5|rigid:yIgEYbtriUGCekJF5kEg1pgN4dI	false	glutathione s tranferase tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P32883	uniprotkb:Q9JHG7	intact:EBI-644267|uniprotkb:P04200|uniprotkb:P08643|ensembl:ENSMUSP00000107339	intact:EBI-644372|uniprotkb:Q80V09|ensembl:ENSMUSP00000062864|ensembl:ENSMUSP00000082596|ensembl:ENSMUSP00000123539|ensembl:ENSMUSP00000151400	psi-mi:rask_mouse(display_long)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)|uniprotkb:Kras(gene name)|psi-mi:Kras(display_short)|uniprotkb:Kras2(gene name synonym)	psi-mi:pk3cg_mouse(display_long)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Pik3cg(gene name)|psi-mi:Pik3cg(display_short)|uniprotkb:Pi3kg1(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8763926|imex:IM-21415-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067259.4|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019002"(GMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030275"(LRR domain binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035900"(response to isolation stress)|go:"GO:0038002"(endocrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR001806(Ras GTPase)|go:"GO:0008284"(positive regulation of cell population proliferation)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|reactome:R-MMU-2179392|reactome:R-MMU-2424491|interpro:IPR027417|mint:P32883|reactome:R-MMU-1169092|reactome:R-MMU-1250347|reactome:R-MMU-2871796|reactome:R-MMU-375165|reactome:R-MMU-4086398|reactome:R-MMU-1433557|reactome:R-MMU-171007|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-210993|reactome:R-MMU-5218921|reactome:R-MMU-5621575|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5658442|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-8849471|reactome:R-MMU-8851805|reactome:R-MMU-8951936|reactome:R-MMU-9607240|reactome:R-MMU-9634635|reactome:R-MMU-9648002|reactome:R-MMU-9674555|ensembl:ENSMUSG00000030265(gene)|ensembl:ENSMUST00000111710(transcript)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007565"(female pregnancy)|refseq:XP_006506981.1|dip:DIP-29362N	refseq:NP_001139672.1|refseq:NP_001139673.1|refseq:NP_064668.2|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|ensembl:ENSMUSG00000020573(gene)|ensembl:ENSMUST00000053215(transcript)|ensembl:ENSMUST00000085469(transcript)|ensembl:ENSMUST00000156904(transcript)|ensembl:ENSMUST00000220366(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0032252"(secretory granule localization)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|reactome:R-MMU-9027276|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|refseq:XP_006515175.1|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|dip:DIP-41862N	-	-	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 2A, Supp Fig. 1D,|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:wRpf3zq2kO/Q0QbC/wp+rJNrBlQ10090	rogid:SV/AI6H65Utm5ENkfXkXQ4lqaao10090	intact-crc:B88C598FD5F2CC6F|rigid:bObnuU0sVVHrKxOiWtkVPgbqHIc	false	glutathione s tranferase tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O35904	uniprotkb:Q61411	intact:EBI-647932|uniprotkb:Q8CJ28|ensembl:ENSMUSP00000101314	intact:EBI-400273|uniprotkb:Q80WD2|uniprotkb:Q6P716|uniprotkb:Q811B9|ensembl:ENSMUSP00000026572|ensembl:ENSMUSP00000095570|uniprotkb:F7BIB2	psi-mi:pk3cd_mouse(display_long)|uniprotkb:Pik3cd(gene name)|psi-mi:Pik3cd(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta(gene name synonym)	psi-mi:rash_mouse(display_long)|uniprotkb:Hras(gene name)|psi-mi:Hras(display_short)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:Hras1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:p21ras(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8764130|imex:IM-21415-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157524.1|refseq:XP_006538715.1|dip:DIP-39841N|ensembl:ENSMUSG00000039936(gene)|ensembl:ENSMUST00000105689(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:1905278"(positive regulation of epithelial tube formation)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037703|interpro:IPR042236|rcsb pdb:2WXF|rcsb pdb:2WXG|rcsb pdb:2WXH|rcsb pdb:2WXI|rcsb pdb:2WXJ|rcsb pdb:2WXK|rcsb pdb:2WXL|rcsb pdb:2WXM|rcsb pdb:2WXN|rcsb pdb:2WXO|rcsb pdb:2WXP|rcsb pdb:2WXQ|rcsb pdb:2WXR|rcsb pdb:2X38|rcsb pdb:4AJW|rcsb pdb:4V0I|rcsb pdb:4XE0|rcsb pdb:5AE8|rcsb pdb:5AE9|rcsb pdb:5I4U|rcsb pdb:5I6U|rcsb pdb:5IS5|rcsb pdb:5L72|rcsb pdb:5NCY|rcsb pdb:5NCZ|rcsb pdb:5NGB|rcsb pdb:5O83|rcsb pdb:5T27|rcsb pdb:5T28|rcsb pdb:5T2B|rcsb pdb:5T2D|rcsb pdb:5T2G|rcsb pdb:5T2I|rcsb pdb:5T2L|rcsb pdb:5T2M|rcsb pdb:5T7F|rcsb pdb:5T8I|rcsb pdb:6DGT|rcsb pdb:6EYZ|rcsb pdb:6EZ6|rcsb pdb:6GY0|rcsb pdb:6HI9|rcsb pdb:6MUL|rcsb pdb:6MUM|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-512988|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-983695	refseq:NP_001123915.1|refseq:NP_001123916.1|refseq:NP_032310.2|ensembl:ENSMUSG00000025499(gene)|ensembl:ENSMUST00000026572(transcript)|ensembl:ENSMUST00000097957(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:Q61411|rcsb pdb:6KYH|reactome:R-MMU-1169092|reactome:R-MMU-1250347|reactome:R-MMU-1433557|reactome:R-MMU-171007|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-1963640|go:"GO:1900029"(positive regulation of ruffle assembly)|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-375165|reactome:R-MMU-3928662|reactome:R-MMU-5218921|reactome:R-MMU-5621575|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5658442|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-8849471|reactome:R-MMU-8851805|reactome:R-MMU-9607240|reactome:R-MMU-9634635|reactome:R-MMU-9648002|refseq:XP_006536222.2|dip:DIP-29361N	-	-	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 2A, Supp Fig. 1D,|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:mcGmhHve+Mi2DhcQ7akqBFC0OfI10090	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw10090	intact-crc:8BEB4A38E15C31FB|rigid:LW/mH2SzKMdWmIJhnrpijRgOKJc	false	flag tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P42337	uniprotkb:P01111	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8763672|imex:IM-21415-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	-	-	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	intact-crc:EEDE1ECB04E9F766|rigid:1f54wetXkAMkp16z4YoqC8SBDgY	false	mutation disrupting interaction strength:208-208,227-227|glutathione s tranferase tag:?-?	myc tag:?-?|mutation:12-12	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P42337	uniprotkb:Q61411	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	intact:EBI-400273|uniprotkb:Q80WD2|uniprotkb:Q6P716|uniprotkb:Q811B9|ensembl:ENSMUSP00000026572|ensembl:ENSMUSP00000095570|uniprotkb:F7BIB2	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:rash_mouse(display_long)|uniprotkb:Hras(gene name)|psi-mi:Hras(display_short)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:Hras1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:p21ras(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8763333|imex:IM-21415-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	refseq:NP_001123915.1|refseq:NP_001123916.1|refseq:NP_032310.2|ensembl:ENSMUSG00000025499(gene)|ensembl:ENSMUST00000026572(transcript)|ensembl:ENSMUST00000097957(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:Q61411|rcsb pdb:6KYH|reactome:R-MMU-1169092|reactome:R-MMU-1250347|reactome:R-MMU-1433557|reactome:R-MMU-171007|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-1963640|go:"GO:1900029"(positive regulation of ruffle assembly)|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-375165|reactome:R-MMU-3928662|reactome:R-MMU-5218921|reactome:R-MMU-5621575|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5658442|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-8849471|reactome:R-MMU-8851805|reactome:R-MMU-9607240|reactome:R-MMU-9634635|reactome:R-MMU-9648002|refseq:XP_006536222.2|dip:DIP-29361N	-	-	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 1A, 2A, Supp Fig. 1D, 2A, 2F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw10090	intact-crc:D3C056C0ED58016A|rigid:YajkhrIeVMP05kYBzrQU1myMLec	false	flag tag:n-n|mutation disrupting interaction strength:208-208,227-227	glutathione s tranferase tag:?-?|mutation decreasing interaction strength:33-33	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P08556	uniprotkb:Q9JHG7	intact:EBI-644882	intact:EBI-644372|uniprotkb:Q80V09|ensembl:ENSMUSP00000062864|ensembl:ENSMUSP00000082596|ensembl:ENSMUSP00000123539|ensembl:ENSMUSP00000151400	psi-mi:rasn_mouse(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:Nras(gene name)|psi-mi:Nras(display_short)	psi-mi:pk3cg_mouse(display_long)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Pik3cg(gene name)|psi-mi:Pik3cg(display_short)|uniprotkb:Pi3kg1(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8763935|imex:IM-21415-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-9648002|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR020849|interpro:IPR027417|go:"GO:0000139"(Golgi membrane)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019003"(GDP binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0016020"(membrane)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|reactome:R-MMU-1169092|reactome:R-MMU-1250347|reactome:R-MMU-1433557|reactome:R-MMU-171007|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-375165|reactome:R-MMU-5218921|reactome:R-MMU-5621575|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5658442|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-8849471|reactome:R-MMU-8851805|reactome:R-MMU-9634635|reactome:R-MMU-9607240	refseq:NP_001139672.1|refseq:NP_001139673.1|refseq:NP_064668.2|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|ensembl:ENSMUSG00000020573(gene)|ensembl:ENSMUST00000053215(transcript)|ensembl:ENSMUST00000085469(transcript)|ensembl:ENSMUST00000156904(transcript)|ensembl:ENSMUST00000220366(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0032252"(secretory granule localization)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|reactome:R-MMU-9027276|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|refseq:XP_006515175.1|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|dip:DIP-41862N	-	-	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 2A, Supp Fig. 1D,|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:d/cSjl7Sse4v4T0S5ipO0mXomX410090	rogid:SV/AI6H65Utm5ENkfXkXQ4lqaao10090	intact-crc:2769D7659A17D2DC|rigid:PfUS/UPtM8YbspwSlLP9aka15Oc	false	glutathione s tranferase tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P42337	uniprotkb:P01116	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	intact:EBI-367415|uniprotkb:P01118|uniprotkb:Q96D10|uniprotkb:B0LPF9|uniprotkb:A8K8Z5|ensembl:ENSP00000256078	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:rask_human(display_long)|uniprotkb:KRAS(gene name)|psi-mi:KRAS(display_short)|uniprotkb:RASK2(gene name synonym)|uniprotkb:KRAS2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8763660|imex:IM-21415-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	refseq:NP_004976.2|refseq:NP_203524.1|refseq:XP_011518955.1|refseq:XP_006719132.1|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035900"(response to isolation stress)|go:"GO:0038002"(endocrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F76|rcsb pdb:6FA1|rcsb pdb:6FA2|rcsb pdb:6FA3|rcsb pdb:6FA4|rcsb pdb:6GJ5|rcsb pdb:6GJ6|rcsb pdb:6GJ7|rcsb pdb:6GJ8|rcsb pdb:6GOD|rcsb pdb:6GOE|rcsb pdb:6GOF|rcsb pdb:6GOG|rcsb pdb:6GOM|rcsb pdb:6GQT|rcsb pdb:6GQW|rcsb pdb:6GQX|rcsb pdb:6GQY|rcsb pdb:6H46|rcsb pdb:6H47|rcsb pdb:6JTN|rcsb pdb:6JTO|rcsb pdb:6JTP|rcsb pdb:6M9W|rcsb pdb:6MBQ|rcsb pdb:6MBT|rcsb pdb:6MBU|rcsb pdb:6MNX|rcsb pdb:6MQG|rcsb pdb:6MQN|rcsb pdb:6MS9|rcsb pdb:6MTA|rcsb pdb:6N2J|rcsb pdb:6N2K|rcsb pdb:6O36|rcsb pdb:6O46|rcsb pdb:6O4Y|rcsb pdb:6O4Z|rcsb pdb:6O51|rcsb pdb:6O53|rcsb pdb:6OB2|rcsb pdb:6OB3|rcsb pdb:6OIM|rcsb pdb:6P0Z|rcsb pdb:6E6G|rcsb pdb:6P8W|rcsb pdb:6P8X|rcsb pdb:6P8Y|rcsb pdb:6P8Z|rcsb pdb:6PGO|rcsb pdb:6PGP|rcsb pdb:6PQ3|rcsb pdb:6PTS|rcsb pdb:6PTW|ensembl:ENSG00000133703(gene)|ensembl:ENST00000256078(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019002"(GMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030275"(LRR domain binding)|rcsb pdb:6QUU|rcsb pdb:6QUV|rcsb pdb:6QUW|rcsb pdb:6QUX|rcsb pdb:6T5B|rcsb pdb:6T5U|rcsb pdb:6T5V|rcsb pdb:6TAM|rcsb pdb:6TAN|rcsb pdb:6USX|rcsb pdb:6USZ|rcsb pdb:6UT0|rcsb pdb:6V5L|rcsb pdb:6V65|rcsb pdb:6V6F|rcsb pdb:6VC8|rcsb pdb:6VJJ|rcsb pdb:6W4E|rcsb pdb:6W4F|rcsb pdb:6WGN|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6YR8|rcsb pdb:6YXW|rcsb pdb:6ZL5|rcsb pdb:6ZLI|rcsb pdb:7ACA|rcsb pdb:7ACF|rcsb pdb:7ACH|rcsb pdb:7ACQ|rcsb pdb:7C40|rcsb pdb:7C41|rcsb pdb:7EYX|rcsb pdb:7F0W|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-4086398|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8951936|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9703465|reactome:R-HSA-9703648|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01116|rcsb pdb:1D8D|rcsb pdb:1D8E|rcsb pdb:1KZO|rcsb pdb:1KZP|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|rcsb pdb:1N4S|rcsb pdb:3GFT|rcsb pdb:4DSN|rcsb pdb:4DSO|rcsb pdb:4EPR|rcsb pdb:4EPT|rcsb pdb:4EPV|rcsb pdb:4EPW|rcsb pdb:4EPX|rcsb pdb:4EPY|rcsb pdb:4L8G|rcsb pdb:4LDJ|rcsb pdb:4LPK|rcsb pdb:4LRW|rcsb pdb:4LUC|rcsb pdb:4LV6|rcsb pdb:4LYF|rcsb pdb:4LYH|rcsb pdb:4LYJ|rcsb pdb:4M1O|rcsb pdb:4M1S|rcsb pdb:4M1T|rcsb pdb:4M1W|rcsb pdb:4M1Y|rcsb pdb:4M21|rcsb pdb:4M22|rcsb pdb:4NMM|rcsb pdb:4OBE|rcsb pdb:4PZY|rcsb pdb:4PZZ|rcsb pdb:4Q01|rcsb pdb:4Q02|rcsb pdb:4Q03|rcsb pdb:4QL3|rcsb pdb:4TQ9|rcsb pdb:4TQA|rcsb pdb:4WA7|rcsb pdb:5F2E|rcsb pdb:5KYK|rcsb pdb:5MLA|rcsb pdb:5MLB|rcsb pdb:5O2S|rcsb pdb:5O2T|rcsb pdb:5OCG|rcsb pdb:5OCO|rcsb pdb:5OCT|rcsb pdb:5TAR|rcsb pdb:5TB5|rcsb pdb:5UFE|rcsb pdb:5UFQ|rcsb pdb:5UK9|rcsb pdb:5UQW|rcsb pdb:5US4|rcsb pdb:5USJ|rcsb pdb:5V6S|rcsb pdb:5V6V|rcsb pdb:5V71|rcsb pdb:5V9L|rcsb pdb:5V9O|rcsb pdb:5V9U|rcsb pdb:5VBM|rcsb pdb:5VP7|rcsb pdb:5VPI|rcsb pdb:5VPY|rcsb pdb:5VPZ|rcsb pdb:5VQ0|rcsb pdb:5VQ1|rcsb pdb:5VQ2|rcsb pdb:5VQ6|rcsb pdb:5VQ8|rcsb pdb:5W22|rcsb pdb:5WHA|rcsb pdb:5WHB|rcsb pdb:5WHD|rcsb pdb:5WHE|rcsb pdb:5WLB|rcsb pdb:5WPM|rcsb pdb:5XCO|rcsb pdb:5YXZ|rcsb pdb:5YY1|rcsb pdb:6ARK|rcsb pdb:6ASA|rcsb pdb:6ASE|rcsb pdb:6B0V|rcsb pdb:6B0Y|rcsb pdb:6BOF|rcsb pdb:6BP1|rcsb pdb:6CC9|rcsb pdb:6CCH|rcsb pdb:6CCX|rcsb pdb:6CU6|rcsb pdb:6E6F|dip:DIP-33951N	-	-	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	rogid:ujXYEgifbSf/thk1UOTW7sKWkX89606	intact-crc:7E60D1F083EEA85D|rigid:l53nTR7nYUkFVmZB4ufKz3IVbdY	false	glutathione s tranferase tag:?-?|mutation disrupting interaction strength:208-208,227-227	myc tag:?-?|mutation:12-12	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O35904	uniprotkb:P08556	intact:EBI-647932|uniprotkb:Q8CJ28|ensembl:ENSMUSP00000101314	intact:EBI-644882	psi-mi:pk3cd_mouse(display_long)|uniprotkb:Pik3cd(gene name)|psi-mi:Pik3cd(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta(gene name synonym)	psi-mi:rasn_mouse(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:Nras(gene name)|psi-mi:Nras(display_short)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8764121|imex:IM-21415-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157524.1|refseq:XP_006538715.1|dip:DIP-39841N|ensembl:ENSMUSG00000039936(gene)|ensembl:ENSMUST00000105689(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:1905278"(positive regulation of epithelial tube formation)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037703|interpro:IPR042236|rcsb pdb:2WXF|rcsb pdb:2WXG|rcsb pdb:2WXH|rcsb pdb:2WXI|rcsb pdb:2WXJ|rcsb pdb:2WXK|rcsb pdb:2WXL|rcsb pdb:2WXM|rcsb pdb:2WXN|rcsb pdb:2WXO|rcsb pdb:2WXP|rcsb pdb:2WXQ|rcsb pdb:2WXR|rcsb pdb:2X38|rcsb pdb:4AJW|rcsb pdb:4V0I|rcsb pdb:4XE0|rcsb pdb:5AE8|rcsb pdb:5AE9|rcsb pdb:5I4U|rcsb pdb:5I6U|rcsb pdb:5IS5|rcsb pdb:5L72|rcsb pdb:5NCY|rcsb pdb:5NCZ|rcsb pdb:5NGB|rcsb pdb:5O83|rcsb pdb:5T27|rcsb pdb:5T28|rcsb pdb:5T2B|rcsb pdb:5T2D|rcsb pdb:5T2G|rcsb pdb:5T2I|rcsb pdb:5T2L|rcsb pdb:5T2M|rcsb pdb:5T7F|rcsb pdb:5T8I|rcsb pdb:6DGT|rcsb pdb:6EYZ|rcsb pdb:6EZ6|rcsb pdb:6GY0|rcsb pdb:6HI9|rcsb pdb:6MUL|rcsb pdb:6MUM|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-512988|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-983695	reactome:R-MMU-9648002|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR020849|interpro:IPR027417|go:"GO:0000139"(Golgi membrane)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019003"(GDP binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0016020"(membrane)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|reactome:R-MMU-1169092|reactome:R-MMU-1250347|reactome:R-MMU-1433557|reactome:R-MMU-171007|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-375165|reactome:R-MMU-5218921|reactome:R-MMU-5621575|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5658442|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-8849471|reactome:R-MMU-8851805|reactome:R-MMU-9634635|reactome:R-MMU-9607240	-	-	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 2A, Supp Fig. 1D,|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:mcGmhHve+Mi2DhcQ7akqBFC0OfI10090	rogid:d/cSjl7Sse4v4T0S5ipO0mXomX410090	intact-crc:B8A37FBC3A311D06|rigid:s4c477nxT9XAwDZdM/UMLh02LWY	false	flag tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O35904	uniprotkb:P32883	intact:EBI-647932|uniprotkb:Q8CJ28|ensembl:ENSMUSP00000101314	intact:EBI-644267|uniprotkb:P04200|uniprotkb:P08643|ensembl:ENSMUSP00000107339	psi-mi:pk3cd_mouse(display_long)|uniprotkb:Pik3cd(gene name)|psi-mi:Pik3cd(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta(gene name synonym)	psi-mi:rask_mouse(display_long)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)|uniprotkb:Kras(gene name)|psi-mi:Kras(display_short)|uniprotkb:Kras2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8764112|imex:IM-21415-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157524.1|refseq:XP_006538715.1|dip:DIP-39841N|ensembl:ENSMUSG00000039936(gene)|ensembl:ENSMUST00000105689(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:1905278"(positive regulation of epithelial tube formation)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037703|interpro:IPR042236|rcsb pdb:2WXF|rcsb pdb:2WXG|rcsb pdb:2WXH|rcsb pdb:2WXI|rcsb pdb:2WXJ|rcsb pdb:2WXK|rcsb pdb:2WXL|rcsb pdb:2WXM|rcsb pdb:2WXN|rcsb pdb:2WXO|rcsb pdb:2WXP|rcsb pdb:2WXQ|rcsb pdb:2WXR|rcsb pdb:2X38|rcsb pdb:4AJW|rcsb pdb:4V0I|rcsb pdb:4XE0|rcsb pdb:5AE8|rcsb pdb:5AE9|rcsb pdb:5I4U|rcsb pdb:5I6U|rcsb pdb:5IS5|rcsb pdb:5L72|rcsb pdb:5NCY|rcsb pdb:5NCZ|rcsb pdb:5NGB|rcsb pdb:5O83|rcsb pdb:5T27|rcsb pdb:5T28|rcsb pdb:5T2B|rcsb pdb:5T2D|rcsb pdb:5T2G|rcsb pdb:5T2I|rcsb pdb:5T2L|rcsb pdb:5T2M|rcsb pdb:5T7F|rcsb pdb:5T8I|rcsb pdb:6DGT|rcsb pdb:6EYZ|rcsb pdb:6EZ6|rcsb pdb:6GY0|rcsb pdb:6HI9|rcsb pdb:6MUL|rcsb pdb:6MUM|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-512988|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-983695	refseq:NP_067259.4|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019002"(GMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030275"(LRR domain binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035900"(response to isolation stress)|go:"GO:0038002"(endocrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR001806(Ras GTPase)|go:"GO:0008284"(positive regulation of cell population proliferation)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|reactome:R-MMU-2179392|reactome:R-MMU-2424491|interpro:IPR027417|mint:P32883|reactome:R-MMU-1169092|reactome:R-MMU-1250347|reactome:R-MMU-2871796|reactome:R-MMU-375165|reactome:R-MMU-4086398|reactome:R-MMU-1433557|reactome:R-MMU-171007|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-210993|reactome:R-MMU-5218921|reactome:R-MMU-5621575|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5658442|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-8849471|reactome:R-MMU-8851805|reactome:R-MMU-8951936|reactome:R-MMU-9607240|reactome:R-MMU-9634635|reactome:R-MMU-9648002|reactome:R-MMU-9674555|ensembl:ENSMUSG00000030265(gene)|ensembl:ENSMUST00000111710(transcript)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007565"(female pregnancy)|refseq:XP_006506981.1|dip:DIP-29362N	-	-	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 2A, Supp Fig. 1D,|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:mcGmhHve+Mi2DhcQ7akqBFC0OfI10090	rogid:wRpf3zq2kO/Q0QbC/wp+rJNrBlQ10090	intact-crc:F0C6AEBA1B3ECE0A|rigid:qFOWJy5KER5Y9xGu1bpD78RV2ks	false	flag tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P62071	uniprotkb:P42337	intact:EBI-8400854|uniprotkb:Q3TA79|uniprotkb:Q9D0H6|uniprotkb:P17082|intact:MINT-86673|uniprotkb:Q8C5D1|ensembl:ENSMUSP00000069752	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	psi-mi:rras2_mouse(display_long)|uniprotkb:Rras2(gene name)|psi-mi:Rras2(display_short)	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8763852|imex:IM-21415-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080122.2|ensembl:ENSMUSG00000055723(gene)|ensembl:ENSMUST00000069449(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0009987"(cellular process)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P62071|reactome:R-MMU-9696273	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	-	function:It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion|comment:mint	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 2A, Supp Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:WW/YiKaC5t0Qy03E7LQTzpIP9BY10090	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	intact-crc:CF8948FD77D4F74B|rigid:iVO8KKsCMw65p1pKwtoYxchxFH4	false	glutathione s tranferase tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P42337	uniprotkb:Q7TN89	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	intact:EBI-8763800|ensembl:ENSMUSP00000033500	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:rase_mouse(display_long)|uniprotkb:Eras(gene name)|psi-mi:Eras(display_short)|uniprotkb:Embryonic stem cell-expressed Ras(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8763797|imex:IM-21415-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	go:"GO:0019003"(GDP binding)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|ensembl:ENSMUSG00000031160(gene)|ensembl:ENSMUST00000033500(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|refseq:NP_853526.1	-	-	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 2A, Supp Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	rogid:7D9/86+O0wwdiqPpdppoFw/rISI10090	intact-crc:BD74A5E30ACEAFE6|rigid:FNUO0qrxIa/wa2q/xrgOL/aBaFI	false	flag tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P10833	uniprotkb:P42337	intact:EBI-8351107|intact:MINT-4133129|ensembl:ENSMUSP00000042150	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	psi-mi:rras_mouse(display_long)|uniprotkb:Rras(gene name)|psi-mi:Rras(display_short)|uniprotkb:p23(gene name synonym)	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8763839|imex:IM-21415-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033127.1|ensembl:ENSMUSG00000038387(gene)|ensembl:ENSMUST00000044111(transcript)|go:"GO:0002521"(leukocyte differentiation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0019003"(GDP binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060325"(face morphogenesis)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P10833|reactome:R-MMU-416550	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	-	comment:mint|function:Regulates the organization of the actin cytoskeleton	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 2A, Supp Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:zsmDFKVvmh8JuGUJr0bb6+BZ1Q010090	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	intact-crc:85D35F502F344DA8|rigid:rwePfo+fTukjEIHyvOK6r3t8gmI	false	glutathione s tranferase tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P08556	uniprotkb:P42337	intact:EBI-644882	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	psi-mi:rasn_mouse(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:Nras(gene name)|psi-mi:Nras(display_short)	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8763357|imex:IM-21415-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-9648002|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR020849|interpro:IPR027417|go:"GO:0000139"(Golgi membrane)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019003"(GDP binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0016020"(membrane)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|reactome:R-MMU-1169092|reactome:R-MMU-1250347|reactome:R-MMU-1433557|reactome:R-MMU-171007|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-375165|reactome:R-MMU-5218921|reactome:R-MMU-5621575|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5658442|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-8849471|reactome:R-MMU-8851805|reactome:R-MMU-9634635|reactome:R-MMU-9607240	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	-	-	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 1A, 2A, Supp. FIg. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:d/cSjl7Sse4v4T0S5ipO0mXomX410090	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	intact-crc:CB6D94A475CCA7B4|rigid:Fh10zNzcatLLbynjjAYjKk+MZYg	false	glutathione s tranferase tag:?-?	flag tag:n-n|mutation disrupting interaction strength:208-208,227-227	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P42337	uniprotkb:P32883	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	intact:EBI-644267|uniprotkb:P04200|uniprotkb:P08643|ensembl:ENSMUSP00000107339	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:rask_mouse(display_long)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)|uniprotkb:Kras(gene name)|psi-mi:Kras(display_short)|uniprotkb:Kras2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8763345|imex:IM-21415-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	refseq:NP_067259.4|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019002"(GMP binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030275"(LRR domain binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035900"(response to isolation stress)|go:"GO:0038002"(endocrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR001806(Ras GTPase)|go:"GO:0008284"(positive regulation of cell population proliferation)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|reactome:R-MMU-2179392|reactome:R-MMU-2424491|interpro:IPR027417|mint:P32883|reactome:R-MMU-1169092|reactome:R-MMU-1250347|reactome:R-MMU-2871796|reactome:R-MMU-375165|reactome:R-MMU-4086398|reactome:R-MMU-1433557|reactome:R-MMU-171007|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-210993|reactome:R-MMU-5218921|reactome:R-MMU-5621575|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5658442|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-8849471|reactome:R-MMU-8851805|reactome:R-MMU-8951936|reactome:R-MMU-9607240|reactome:R-MMU-9634635|reactome:R-MMU-9648002|reactome:R-MMU-9674555|ensembl:ENSMUSG00000030265(gene)|ensembl:ENSMUST00000111710(transcript)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007565"(female pregnancy)|refseq:XP_006506981.1|dip:DIP-29362N	-	-	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 1A, 2A, Supp Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	rogid:wRpf3zq2kO/Q0QbC/wp+rJNrBlQ10090	intact-crc:18169E69AB6791CD|rigid:VNCVtMmUrK/sEzynROl/EkPcE90	false	flag tag:n-n|mutation disrupting interaction strength:208-208,227-227	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P42337	uniprotkb:P01112	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	intact:EBI-350145|uniprotkb:Q9BR65|uniprotkb:Q14080|uniprotkb:Q6FHV9|uniprotkb:B5BUA0|uniprotkb:Q9UCE2|ensembl:ENSP00000309845|ensembl:ENSP00000380723|ensembl:ENSP00000407586|ensembl:ENSP00000480686|ensembl:ENSP00000482366|ensembl:ENSP00000488757	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:rash_human(display_long)|uniprotkb:HRAS(gene name)|psi-mi:HRAS(display_short)|uniprotkb:HRAS1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:p21ras(gene name synonym)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:Ha-Ras(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8763644|imex:IM-21415-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	refseq:NP_001123914.1|refseq:NP_005334.1|refseq:NP_789765.1|ensembl:ENSG00000174775(gene)|ensembl:ENSG00000276536(gene)|ensembl:ENST00000311189(transcript)|ensembl:ENST00000397596(transcript)|ensembl:ENST00000451590(transcript)|ensembl:ENST00000610977(transcript)|ensembl:ENST00000615062(transcript)|ensembl:ENST00000631404(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01112|rcsb pdb:121P|rcsb pdb:1AA9|rcsb pdb:1AGP|rcsb pdb:1BKD|rcsb pdb:1CLU|rcsb pdb:1CRP|rcsb pdb:1CRQ|rcsb pdb:1CRR|rcsb pdb:1CTQ|rcsb pdb:1GNP|rcsb pdb:1GNQ|rcsb pdb:1GNR|rcsb pdb:1HE8|rcsb pdb:1IAQ|rcsb pdb:1IOZ|rcsb pdb:1JAH|rcsb pdb:1JAI|rcsb pdb:1K8R|rcsb pdb:1LF0|rcsb pdb:1LF5|rcsb pdb:1LFD|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1P2S|rcsb pdb:1P2T|rcsb pdb:1P2U|rcsb pdb:1P2V|rcsb pdb:1PLJ|rcsb pdb:1PLK|rcsb pdb:1PLL|rcsb pdb:1Q21|rcsb pdb:1QRA|rcsb pdb:1RVD|rcsb pdb:1WQ1|rcsb pdb:1XCM|rcsb pdb:1XD2|rcsb pdb:1XJ0|rcsb pdb:1ZVQ|rcsb pdb:1ZW6|rcsb pdb:221P|rcsb pdb:2C5L|rcsb pdb:2CE2|rcsb pdb:2CL0|rcsb pdb:2CL6|rcsb pdb:2CL7|rcsb pdb:2CLC|rcsb pdb:2CLD|rcsb pdb:2EVW|rcsb pdb:2GDP|rcsb pdb:2LCF|rcsb pdb:2LWI|rcsb pdb:2N42|rcsb pdb:2N46|rcsb pdb:2Q21|rcsb pdb:2QUZ|rcsb pdb:2RGA|rcsb pdb:2RGB|rcsb pdb:2RGC|rcsb pdb:2RGD|rcsb pdb:2RGE|rcsb pdb:2RGG|rcsb pdb:2UZI|rcsb pdb:2VH5|rcsb pdb:2X1V|rcsb pdb:3DDC|rcsb pdb:3I3S|rcsb pdb:3K8Y|rcsb pdb:3K9L|rcsb pdb:3K9N|rcsb pdb:3KKM|rcsb pdb:3KKN|rcsb pdb:3KUD|rcsb pdb:3L8Y|rcsb pdb:3L8Z|rcsb pdb:3LBH|rcsb pdb:3LBI|rcsb pdb:3LBN|rcsb pdb:3LO5|rcsb pdb:3OIU|rcsb pdb:3OIV|rcsb pdb:3OIW|rcsb pdb:3RRY|rcsb pdb:3RRZ|rcsb pdb:3RS0|rcsb pdb:3RS2|rcsb pdb:3RS3|rcsb pdb:3RS4|rcsb pdb:3RS5|rcsb pdb:3RS7|rcsb pdb:3RSL|rcsb pdb:3RSO|rcsb pdb:3TGP|rcsb pdb:421P|rcsb pdb:4DLR|rcsb pdb:4DLS|rcsb pdb:4DLT|rcsb pdb:4DLU|rcsb pdb:4DLV|rcsb pdb:4DLW|rcsb pdb:4DLX|rcsb pdb:4DLY|rcsb pdb:4DLZ|rcsb pdb:4DST|rcsb pdb:4DSU|rcsb pdb:4EFL|rcsb pdb:4EFM|rcsb pdb:4EFN|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4K81|rcsb pdb:4L9S|rcsb pdb:4L9W|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4Q21|rcsb pdb:4RSG|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:4XVQ|rcsb pdb:4XVR|rcsb pdb:521P|rcsb pdb:5B2Z|rcsb pdb:5B30|rcsb pdb:5E95|rcsb pdb:5P21|rcsb pdb:5VBE|rcsb pdb:5VBZ|rcsb pdb:5WDO|rcsb pdb:5WDP|rcsb pdb:5WDQ|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-3928662|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6Q21|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:5WPL|rcsb pdb:5X9S|rcsb pdb:5ZC6|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:621P|rcsb pdb:6AMB|rcsb pdb:6AXG|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6DZH|rcsb pdb:6E6C|rcsb pdb:6E6P|rcsb pdb:6MQT|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6ZJ0|rcsb pdb:6ZL3|rcsb pdb:721P|rcsb pdb:7JHP|rcsb pdb:7L0F|rcsb pdb:7L0G|rcsb pdb:821P|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|refseq:NP_001304983.1|dip:DIP-1050N	-	-	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw9606	intact-crc:08DC477C583C72CC|rigid:JI5pWmCAM7SrkSqR94ehhuliwZ4	false	glutathione s tranferase tag:?-?|mutation disrupting interaction strength:208-208,227-227	myc tag:?-?|mutation:12-12	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P62071	uniprotkb:O35904	intact:EBI-8400854|uniprotkb:Q3TA79|uniprotkb:Q9D0H6|uniprotkb:P17082|intact:MINT-86673|uniprotkb:Q8C5D1|ensembl:ENSMUSP00000069752	intact:EBI-647932|uniprotkb:Q8CJ28|ensembl:ENSMUSP00000101314	psi-mi:rras2_mouse(display_long)|uniprotkb:Rras2(gene name)|psi-mi:Rras2(display_short)	psi-mi:pk3cd_mouse(display_long)|uniprotkb:Pik3cd(gene name)|psi-mi:Pik3cd(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8764012|imex:IM-21415-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080122.2|ensembl:ENSMUSG00000055723(gene)|ensembl:ENSMUST00000069449(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0009987"(cellular process)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P62071|reactome:R-MMU-9696273	refseq:NP_001157524.1|refseq:XP_006538715.1|dip:DIP-39841N|ensembl:ENSMUSG00000039936(gene)|ensembl:ENSMUST00000105689(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:1905278"(positive regulation of epithelial tube formation)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037703|interpro:IPR042236|rcsb pdb:2WXF|rcsb pdb:2WXG|rcsb pdb:2WXH|rcsb pdb:2WXI|rcsb pdb:2WXJ|rcsb pdb:2WXK|rcsb pdb:2WXL|rcsb pdb:2WXM|rcsb pdb:2WXN|rcsb pdb:2WXO|rcsb pdb:2WXP|rcsb pdb:2WXQ|rcsb pdb:2WXR|rcsb pdb:2X38|rcsb pdb:4AJW|rcsb pdb:4V0I|rcsb pdb:4XE0|rcsb pdb:5AE8|rcsb pdb:5AE9|rcsb pdb:5I4U|rcsb pdb:5I6U|rcsb pdb:5IS5|rcsb pdb:5L72|rcsb pdb:5NCY|rcsb pdb:5NCZ|rcsb pdb:5NGB|rcsb pdb:5O83|rcsb pdb:5T27|rcsb pdb:5T28|rcsb pdb:5T2B|rcsb pdb:5T2D|rcsb pdb:5T2G|rcsb pdb:5T2I|rcsb pdb:5T2L|rcsb pdb:5T2M|rcsb pdb:5T7F|rcsb pdb:5T8I|rcsb pdb:6DGT|rcsb pdb:6EYZ|rcsb pdb:6EZ6|rcsb pdb:6GY0|rcsb pdb:6HI9|rcsb pdb:6MUL|rcsb pdb:6MUM|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-512988|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-983695	-	function:It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion|comment:mint	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 2A, Supp Fig. 1D,|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:WW/YiKaC5t0Qy03E7LQTzpIP9BY10090	rogid:mcGmhHve+Mi2DhcQ7akqBFC0OfI10090	intact-crc:2E6BF40A1843DED2|rigid:KMTIzZEa16liTt4hKI6nDa9FTUc	false	glutathione s tranferase tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P62071	uniprotkb:Q9JHG7	intact:EBI-8400854|uniprotkb:Q3TA79|uniprotkb:Q9D0H6|uniprotkb:P17082|intact:MINT-86673|uniprotkb:Q8C5D1|ensembl:ENSMUSP00000069752	intact:EBI-644372|uniprotkb:Q80V09|ensembl:ENSMUSP00000062864|ensembl:ENSMUSP00000082596|ensembl:ENSMUSP00000123539|ensembl:ENSMUSP00000151400	psi-mi:rras2_mouse(display_long)|uniprotkb:Rras2(gene name)|psi-mi:Rras2(display_short)	psi-mi:pk3cg_mouse(display_long)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Pik3cg(gene name)|psi-mi:Pik3cg(display_short)|uniprotkb:Pi3kg1(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8764003|imex:IM-21415-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080122.2|ensembl:ENSMUSG00000055723(gene)|ensembl:ENSMUST00000069449(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0009987"(cellular process)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P62071|reactome:R-MMU-9696273	refseq:NP_001139672.1|refseq:NP_001139673.1|refseq:NP_064668.2|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|ensembl:ENSMUSG00000020573(gene)|ensembl:ENSMUST00000053215(transcript)|ensembl:ENSMUST00000085469(transcript)|ensembl:ENSMUST00000156904(transcript)|ensembl:ENSMUST00000220366(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0032252"(secretory granule localization)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|reactome:R-MMU-9027276|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|refseq:XP_006515175.1|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|dip:DIP-41862N	-	function:It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion|comment:mint	-	comment:RAS proteins are GTP-gamma-S-loaded|figure legend:Fig. 2A, Supp Fig. 1D,|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:WW/YiKaC5t0Qy03E7LQTzpIP9BY10090	rogid:SV/AI6H65Utm5ENkfXkXQ4lqaao10090	intact-crc:A91D3DF1BB69DB80|rigid:PKEQBftP0Sr9znS7xCeiyORpv+M	false	glutathione s tranferase tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q91Z61	uniprotkb:Q8BTI9	intact:EBI-8763888|ensembl:ENSMUSP00000055605	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	psi-mi:dira1_mouse(display_long)|uniprotkb:Diras1(gene name)|psi-mi:Diras1(display_short)|uniprotkb:Gbts1(gene name synonym)|uniprotkb:Distinct subgroup of the Ras family member 1(gene name synonym)|uniprotkb:Small GTP-binding tumor suppressor 1(gene name synonym)	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8763882|imex:IM-21415-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000043670(gene)|ensembl:ENSMUST00000055125(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0019003"(GDP binding)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|refseq:NP_660252.1|refseq:XP_006513501.1	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	-	-	-	figure legend:2A, Supp. Fig. 1C, 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:xVDFO+gGMVayGOjBgL3pAtcp/rs10090	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	intact-crc:0AA7CF2D71B676F2|rigid:+TvluD4NZgkg+uoebHSjX10RGrA	false	glutathione s tranferase tag:?-?|mutation decreasing interaction strength:37-37	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5PR73	uniprotkb:Q8BTI9	intact:EBI-771928|ensembl:ENSMUSP00000055416	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	psi-mi:dira2_mouse(display_long)|uniprotkb:Distinct subgroup of the Ras family member 2(gene name synonym)|uniprotkb:Diras2(gene name)|psi-mi:Diras2(display_short)	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8763909|imex:IM-21415-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001019645.1|refseq:XP_006517013.1|ensembl:ENSMUSG00000047842(gene)|ensembl:ENSMUST00000057442(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0019003"(GDP binding)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	-	-	-	figure legend:2A, Supp. Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:1t8uBB5z1Yw5PuwrKbzPFA65YAg10090	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	intact-crc:9F0A0B114BC847BE|rigid:E65+ASg9kmcg/nr5HYea/SYSfMs	false	glutathione s tranferase tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8BTI9	uniprotkb:P60766	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	intact:EBI-81763|ensembl:ENSMUSP00000054634|uniprotkb:A2A9U6|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q3THZ7|uniprotkb:Q3TJK6|uniprotkb:Q545V0|uniprotkb:Q6P201|uniprotkb:Q8BQ51	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:cdc42_mouse(display_long)|uniprotkb:Cdc42(gene name)|psi-mi:Cdc42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8764162|imex:IM-21415-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	ensembl:ENSMUSG00000006699(gene)|ensembl:ENSMUST00000051477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|refseq:NP_033991.1|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0043209"(myelin sheath)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051647"(nucleus localization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071944"(cell periphery)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60766|rcsb pdb:3EG5|rcsb pdb:5C2J|reactome:R-MMU-114604|reactome:R-MMU-182971|reactome:R-MMU-2029482|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-525793|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5687128|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-983231|go:"GO:0048664"(neuron fate determination)|refseq:NP_001230698.1|dip:DIP-32554N	-	-	-	figure legend:Fig 2F Supp Fig. 2D, 3A,|comment:Binding is GTP dependent. p85 was also pulled down in this interaction but could not be mapped to a single gene product.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU10090	intact-crc:7044620B61B9F025|rigid:Ub719R48XPcpdRv/YenKbxnu5SY	false	mutation decreasing interaction strength:205-205,224-224|mutation decreasing interaction strength:219-219|mutation disrupting interaction strength:227-227|mutation disrupting interaction strength:231-231|mutation decreasing interaction strength:183-183|mutation decreasing interaction strength:185-185|mutation disrupting interaction strength:186-186|mutation disrupting interaction strength:187-187|mutation decreasing interaction strength:190-190|mutation disrupting interaction strength:192-192|mutation decreasing interaction strength:194-194|mutation disrupting interaction strength:229-229|mutation disrupting interaction strength:192-192|mutation disrupting interaction strength:194-194|mutation disrupting interaction strength:202-202|mutation disrupting interaction strength:203-203|mutation disrupting interaction strength:203-203|mutation decreasing interaction strength:207-207|mutation decreasing interaction strength:223-223|flag tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P84096	uniprotkb:Q8BTI9	intact:EBI-8329018|uniprotkb:Q8NI04|uniprotkb:P35238|intact:MINT-4132387|ensembl:ENSMUSP00000095832|ensembl:ENSMUSP00000102536	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	psi-mi:rhog_mouse(display_long)|uniprotkb:Rhog(gene name)|psi-mi:Rhog(display_short)|uniprotkb:Arhg(gene name synonym)|uniprotkb:Sid10750(gene name synonym)|uniprotkb:Sid 10750(gene name synonym)	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8764170|imex:IM-21415-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062512.1|ensembl:ENSMUSG00000073982(gene)|ensembl:ENSMUST00000098230(transcript)|ensembl:ENSMUST00000106923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR042734|mint:P84096|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-5625970|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-9013408	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	-	comment:mint	-	figure legend:Supp Fig. 2D|comment:Binding is GTP dependent|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:9PItVl1k5j6JhIDqwqcov1E/N8w10090	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	intact-crc:363E266C0FA4F86C|rigid:qdIFXX95y6kZnYI1w8gIXEzHt4I	false	glutathione s tranferase tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P63001	uniprotkb:Q8BTI9	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8764154|imex:IM-21415-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	-	-	-	figure legend:Fig 2F,   3D Supp Fig. 2D,  3A, 3B|comment:"Binding is GTP-dependent (GTP-gamma-S), p85 was also pulled down in this interaction but could not be mapped to a single gene product."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	intact-crc:A67866C53ECFF745|rigid:g1gwk3/bakBhOEutk0Q6oB2sl0g	false	glutathione s tranferase tag:?-?|mutation decreasing interaction strength:33-33	flag tag:n-n|mutation decreasing interaction strength:205-205,224-224|mutation decreasing interaction strength:183-183|mutation disrupting interaction strength:186-186|mutation disrupting interaction strength:192-192|mutation decreasing interaction strength:194-194|mutation disrupting interaction strength:194-194|mutation disrupting interaction strength:203-203|mutation decreasing interaction strength:207-207|mutation decreasing interaction strength:223-223|mutation disrupting interaction strength:187-187|mutation decreasing interaction strength:190-190|mutation disrupting interaction strength:192-192|mutation disrupting interaction strength:202-202|mutation disrupting interaction strength:203-203|mutation decreasing interaction strength:219-219|mutation decreasing interaction strength:227-227|mutation decreasing interaction strength:185-185|mutation decreasing interaction strength:190-190|mutation disrupting interaction strength:229-229|mutation decreasing interaction strength:231-231	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8BTI9	uniprotkb:Q61411	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	intact:EBI-400273|uniprotkb:Q80WD2|uniprotkb:Q6P716|uniprotkb:Q811B9|ensembl:ENSMUSP00000026572|ensembl:ENSMUSP00000095570|uniprotkb:F7BIB2	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:rash_mouse(display_long)|uniprotkb:Hras(gene name)|psi-mi:Hras(display_short)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:Hras1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:p21ras(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8764321|imex:IM-21415-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	refseq:NP_001123915.1|refseq:NP_001123916.1|refseq:NP_032310.2|ensembl:ENSMUSG00000025499(gene)|ensembl:ENSMUST00000026572(transcript)|ensembl:ENSMUST00000097957(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:Q61411|rcsb pdb:6KYH|reactome:R-MMU-1169092|reactome:R-MMU-1250347|reactome:R-MMU-1433557|reactome:R-MMU-171007|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-1963640|go:"GO:1900029"(positive regulation of ruffle assembly)|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-375165|reactome:R-MMU-3928662|reactome:R-MMU-5218921|reactome:R-MMU-5621575|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5658442|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-8849471|reactome:R-MMU-8851805|reactome:R-MMU-9607240|reactome:R-MMU-9634635|reactome:R-MMU-9648002|refseq:XP_006536222.2|dip:DIP-29361N	-	-	-	figure legend:Fig 3F, Supp Fig. 3C|comment:Interaction occurs in the presence of GTP-gamma-S|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.71x10^-6(molar)	2013/09/16	2014/10/16	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw10090	intact-crc:08D55AEF6499A4F3|rigid:ysYGnvcFczx3DcchRv52Y8pbMZs	false	mutation disrupting interaction strength:205-205,224-224	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8BTI9	uniprotkb:P60766	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	intact:EBI-81763|ensembl:ENSMUSP00000054634|uniprotkb:A2A9U6|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q3THZ7|uniprotkb:Q3TJK6|uniprotkb:Q545V0|uniprotkb:Q6P201|uniprotkb:Q8BQ51	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:cdc42_mouse(display_long)|uniprotkb:Cdc42(gene name)|psi-mi:Cdc42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8764312|imex:IM-21415-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	ensembl:ENSMUSG00000006699(gene)|ensembl:ENSMUST00000051477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|refseq:NP_033991.1|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0043209"(myelin sheath)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051647"(nucleus localization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071944"(cell periphery)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60766|rcsb pdb:3EG5|rcsb pdb:5C2J|reactome:R-MMU-114604|reactome:R-MMU-182971|reactome:R-MMU-2029482|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-525793|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5687128|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-983231|go:"GO:0048664"(neuron fate determination)|refseq:NP_001230698.1|dip:DIP-32554N	-	-	-	figure legend:Fig 3E, 3F, Supp Fig. 3C|comment:Interaction occurs in the presence of GTP-gamma-S|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.9x10^-6(molar)	2013/09/16	2014/10/16	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU10090	intact-crc:D6DCB5DB07E41EFF|rigid:Ub719R48XPcpdRv/YenKbxnu5SY	false	mutation disrupting interaction strength:205-205,224-224	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8BTI9	uniprotkb:P63001	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8764303|imex:IM-21415-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	-	-	-	figure legend:Fig 3E, 3F, Supp Fig. 3C|comment:Interaction occurs in the presence of GTP-gamma-S|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.47x10^-6(molar)	2013/09/16	2014/10/16	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	intact-crc:A8EEC4FAFB044737|rigid:g1gwk3/bakBhOEutk0Q6oB2sl0g	false	mutation disrupting interaction strength:205-205,244-244	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:18348"	uniprotkb:Q8BTI9	intact:EBI-1257123	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	psi-mi:1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate(display_short)|psi-mi:"CHEBI:18348"(display_long)	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8763715|imex:IM-21415-8	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)	-	-	figure legend:Fig. 1F, 1G, 2C, 2G, 2H, 3B|agonist:Gbeta-gamma subunits|agonist:"Gbeta-gamma subunits and platelet-derived growth factor receptor-derived phosphotyrosine peptide (pY740)"|agonist:Rac1|agonist:Cdc42|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	-	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	intact-crc:0E8B4169999F9461	false	-	sufficient binding region:174-234(IPR000341)|mutation decreasing interaction rate:205-205,224-224	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P63001	uniprotkb:Q8BTI9	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9525216|imex:IM-21415-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	-	-	-	figure legend:Fig 3A/C, 2E, Supp 2E|comment:"Binding is GTP-dependent (GTP-gamma-S), p85 was also pulled down in this interaction but could not be mapped to a single gene product."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	intact-crc:4F17F92FF108F241|rigid:g1gwk3/bakBhOEutk0Q6oB2sl0g	false	mutation decreasing interaction strength:33-33|glutathione s tranferase tag:?-?	mutation disrupting interaction:205-205,224-224	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8BTI9	uniprotkb:Q91Z61	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	intact:EBI-8763888|ensembl:ENSMUSP00000055605	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:dira1_mouse(display_long)|uniprotkb:Diras1(gene name)|psi-mi:Diras1(display_short)|uniprotkb:Gbts1(gene name synonym)|uniprotkb:Distinct subgroup of the Ras family member 1(gene name synonym)|uniprotkb:Small GTP-binding tumor suppressor 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9525291|imex:IM-21415-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	ensembl:ENSMUSG00000043670(gene)|ensembl:ENSMUST00000055125(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0019003"(GDP binding)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|refseq:NP_660252.1|refseq:XP_006513501.1	-	-	-	figure legend:Supp. Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	rogid:xVDFO+gGMVayGOjBgL3pAtcp/rs10090	intact-crc:D2B841ED0BDD3493|rigid:+TvluD4NZgkg+uoebHSjX10RGrA	false	-	glutathione s tranferase tag:?-?|mutation decreasing interaction strength:37-37	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8BTI9	uniprotkb:P60766	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	intact:EBI-81763|ensembl:ENSMUSP00000054634|uniprotkb:A2A9U6|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q3THZ7|uniprotkb:Q3TJK6|uniprotkb:Q545V0|uniprotkb:Q6P201|uniprotkb:Q8BQ51	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:cdc42_mouse(display_long)|uniprotkb:Cdc42(gene name)|psi-mi:Cdc42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9525303|imex:IM-21415-36	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	ensembl:ENSMUSG00000006699(gene)|ensembl:ENSMUST00000051477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|refseq:NP_033991.1|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0043209"(myelin sheath)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051647"(nucleus localization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071944"(cell periphery)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60766|rcsb pdb:3EG5|rcsb pdb:5C2J|reactome:R-MMU-114604|reactome:R-MMU-182971|reactome:R-MMU-2029482|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-525793|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5687128|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-983231|go:"GO:0048664"(neuron fate determination)|refseq:NP_001230698.1|dip:DIP-32554N	-	-	-	figure legend:Fig 2E, 3A/C|comment:Binding is GTP dependent. p85 was also pulled down in this interaction but could not be mapped to a single gene product.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU10090	intact-crc:2C7E083A810B09E6|rigid:Ub719R48XPcpdRv/YenKbxnu5SY	false	mutation disrupting interaction:205-205,224-224	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P84096	uniprotkb:Q8BTI9	intact:EBI-8329018|uniprotkb:Q8NI04|uniprotkb:P35238|intact:MINT-4132387|ensembl:ENSMUSP00000095832|ensembl:ENSMUSP00000102536	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	psi-mi:rhog_mouse(display_long)|uniprotkb:Rhog(gene name)|psi-mi:Rhog(display_short)|uniprotkb:Arhg(gene name synonym)|uniprotkb:Sid10750(gene name synonym)|uniprotkb:Sid 10750(gene name synonym)	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9525207|imex:IM-21415-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062512.1|ensembl:ENSMUSG00000073982(gene)|ensembl:ENSMUST00000098230(transcript)|ensembl:ENSMUST00000106923(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR042734|mint:P84096|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-5625970|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-9013408	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	-	comment:mint	-	figure legend:Fig. 2E|comment:Binding is GTP dependent|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:9PItVl1k5j6JhIDqwqcov1E/N8w10090	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	intact-crc:4A4DB10CD73367DA|rigid:qdIFXX95y6kZnYI1w8gIXEzHt4I	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92556	uniprotkb:P62880	intact:EBI-346417|uniprotkb:Q29R79|uniprotkb:Q96PB0|uniprotkb:Q9H0I1|uniprotkb:A4D1X6|uniprotkb:Q6ZTJ0|ensembl:ENSP00000312185|ensembl:ENSP00000394458|ensembl:ENSP00000406952	intact:EBI-356951|uniprotkb:P11016|uniprotkb:P54312|ensembl:ENSMUSP00000031726|ensembl:ENSMUSP00000129353	psi-mi:elmo1_human(display_long)|uniprotkb:ELMO1(gene name)|psi-mi:ELMO1(display_short)|uniprotkb:KIAA0281(gene name synonym)|uniprotkb:Protein ced-12 homolog(gene name synonym)	psi-mi:gbb2_mouse(display_long)|uniprotkb:Gnb2(gene name)|psi-mi:Gnb2(display_short)|uniprotkb:Transducin beta chain 2(gene name synonym)|uniprotkb:G protein subunit beta-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fritsch et al. (2013)	pubmed:23706742|imex:IM-21415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8764414|imex:IM-21415-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006715868.1|refseq:NP_569709.1|refseq:XP_005249976.1|refseq:NP_001034548.1|refseq:NP_001193409.1|refseq:NP_001193411.1|refseq:NP_055615.8|refseq:XP_011513956.1|refseq:XP_016868327.1|refseq:XP_016868328.1|dip:DIP-31095N|ensembl:ENSG00000155849(gene)|ensembl:ENST00000310758(transcript)|ensembl:ENST00000442504(transcript)|ensembl:ENST00000448602(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0048870"(cell motility)|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030715|mint:Q92556|rcsb pdb:2RQR|rcsb pdb:2VSZ|rcsb pdb:3A98|rcsb pdb:6JPP|rcsb pdb:6TGB|rcsb pdb:6TGC|reactome:R-HSA-164944|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9664422	refseq:NP_034442.1|refseq:XP_006504616.1|ensembl:ENSMUSG00000029713(gene)|ensembl:ENSMUST00000031726(transcript)|ensembl:ENSMUST00000150063(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043209"(myelin sheath)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051020"(GTPase binding)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62880|reactome:R-MMU-1296041|reactome:R-MMU-202040|reactome:R-MMU-381676|reactome:R-MMU-392170|reactome:R-MMU-392451|reactome:R-MMU-392851|reactome:R-MMU-400042|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-418217|reactome:R-MMU-418555|reactome:R-MMU-418592|reactome:R-MMU-418594|reactome:R-MMU-418597|reactome:R-MMU-420092|reactome:R-MMU-428930|reactome:R-MMU-432040|reactome:R-MMU-456926|reactome:R-MMU-500657|reactome:R-MMU-6814122|reactome:R-MMU-8964315|reactome:R-MMU-8964616|reactome:R-MMU-9009391|reactome:R-MMU-997272	-	-	-	figure legend:Fig. 6E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/16	2014/10/16	rogid:sW9Vj+Vej/oJb9qQxkbtIipDYXI9606	rogid:dingPUxdpAhe7UMLquv0eqXNtUM10090	intact-crc:C4813F5BDA5BBD1B|rigid:fX2wesElnACe2DbQMr/aFT7KxBA	false	necessary binding region:301-362|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)