#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UH77	uniprotkb:Q13618	intact:EBI-8524663|uniprotkb:Q9ULU0|uniprotkb:B2RBK7|intact:UNK-6172988|uniprotkb:Q9UH76|uniprotkb:Q9UH75|uniprotkb:Q9Y6V6|ensembl:ENSP00000312397	intact:EBI-456129|uniprotkb:O75415|uniprotkb:Q569L3|uniprotkb:Q9UBI8|uniprotkb:B8ZZC3|uniprotkb:Q9UET7|uniprotkb:A8K536|ensembl:ENSP00000264414	psi-mi:klhl3_human(display_long)|uniprotkb:KLHL3(gene name)|psi-mi:KLHL3(display_short)|uniprotkb:KIAA1129(gene name synonym)	psi-mi:cul3_human(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wu et al. (2013)	mint:MINT-8427680|mint:d-13-00079r2|pubmed:23665031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8524699|mint:MINT-8427707	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_059111.2|refseq:NP_001244124.1|refseq:NP_001244123.1|ensembl:ENSG00000146021(gene)|ensembl:ENST00000309755(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0050801"(ion homeostasis)|go:"GO:0061912"(selective autophagy)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0072156"(distal tubule morphogenesis)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030578|rcsb pdb:4CH9|rcsb pdb:4HXI|rcsb pdb:5NKP|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8427710(identity)	refseq:NP_003581.1|refseq:NP_001244126.1|refseq:NP_001244127.1|dip:DIP-31611N|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000922"(spindle pole)|go:"GO:0001831"(trophectodermal cellular morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017145"(stem cell division)|go:"GO:0030030"(cell projection organization)|go:"GO:0030332"(cyclin binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031208"(POZ domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0072576"(liver morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13618|rcsb pdb:2MYL|rcsb pdb:2MYM|rcsb pdb:4AP2|rcsb pdb:4APF|rcsb pdb:4EOZ|rcsb pdb:4HXI|rcsb pdb:5NLB|rcsb pdb:6I2M|reactome:R-HSA-4641258|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-9706019|reactome:R-HSA-983168|mint:MINT-8427709(identity)	-	comment:mint|comment:homomint|function:Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	-	figure legend:f2d|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/24	2014/10/16	rogid:6iZNPY/wNDhLlUWeFLl0FyqtFXM9606	rogid:xI/8pHB9nckOW629STOqKba4KzQ9606	intact-crc:A419FCF04E094007|rigid:VptSgfIoOzqqKVr/ujImNRGyrEU	false	ha tag:?-?(MINT-8427716)	glutathione s tranferase tag:?-?(MINT-8427712)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UH77	uniprotkb:Q96J92	intact:EBI-8524663|uniprotkb:Q9ULU0|uniprotkb:B2RBK7|intact:UNK-6172988|uniprotkb:Q9UH76|uniprotkb:Q9UH75|uniprotkb:Q9Y6V6|ensembl:ENSP00000312397	intact:EBI-766352|uniprotkb:Q8N8X3|uniprotkb:Q8N8Z2|uniprotkb:Q96DT8|uniprotkb:Q9BYS5|uniprotkb:B0LPI0|intact:EBI-28967389|ensembl:ENSP00000246914	psi-mi:klhl3_human(display_long)|uniprotkb:KLHL3(gene name)|psi-mi:KLHL3(display_short)|uniprotkb:KIAA1129(gene name synonym)	psi-mi:wnk4_human(display_long)|uniprotkb:Protein kinase with no lysine 4(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 4(gene name synonym)|uniprotkb:WNK4(gene name)|psi-mi:WNK4(display_short)|uniprotkb:PRKWNK4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wu et al. (2013)	mint:MINT-8427680|mint:d-13-00079r2|pubmed:23665031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8524716|mint:MINT-8427720	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_059111.2|refseq:NP_001244124.1|refseq:NP_001244123.1|ensembl:ENSG00000146021(gene)|ensembl:ENST00000309755(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0050801"(ion homeostasis)|go:"GO:0061912"(selective autophagy)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0072156"(distal tubule morphogenesis)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030578|rcsb pdb:4CH9|rcsb pdb:4HXI|rcsb pdb:5NKP|reactome:R-HSA-8951664|reactome:R-HSA-983168|mint:MINT-8427722(identity)	refseq:NP_115763.2|ensembl:ENSP00000246914|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0072156"(distal tubule morphogenesis)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0019869"(chloride channel inhibitor activity)|ensembl:ENSG00000126562(gene)|ensembl:ENST00000246914(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0008104"(protein localization)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|interpro:IPR024678|mint:Q96J92|rcsb pdb:2V3S|rcsb pdb:4CH9|rcsb pdb:4CHB|reactome:R-HSA-2672351|mint:MINT-8427726(identity)	-	comment:mint|comment:homomint|function:Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	-	figure legend:f2d|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/24	2014/10/16	rogid:6iZNPY/wNDhLlUWeFLl0FyqtFXM9606	rogid:RiSrW6NfbbSbmUZixfxAvv+QnEU9606	intact-crc:AB4694B79FFEB5DF|rigid:mVcfsd98zE/DEY33uSEzxmv30QI	false	ha tag:?-?(MINT-8427723)	glutathione s tranferase tag:?-?(MINT-8427727)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)