#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P70371	uniprotkb:Q6ZQJ5	intact:EBI-6919183|ensembl:ENSMUSP00000140744|uniprotkb:Q9CY71	intact:EBI-6919222|ensembl:ENSMUSP00000115750|uniprotkb:Q14BM9|uniprotkb:Q8BSZ0|uniprotkb:Q8R3J3	psi-mi:terf1_mouse(display_long)|uniprotkb:Terf1(gene name)|psi-mi:Terf1(display_short)|uniprotkb:Trf1(gene name synonym)|uniprotkb:TTAGGG repeat-binding factor 1(gene name synonym)	psi-mi:dna2_mouse(display_long)|uniprotkb:Dna2(gene name)|psi-mi:Dna2(display_short)|uniprotkb:Dna2l(gene name synonym)|uniprotkb:Kiaa0083(gene name synonym)|uniprotkb:DNA replication ATP-dependent helicase-like homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lin et al. (2013)	pubmed:23604072|imex:IM-21125	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6919166|imex:IM-21125-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025925(gene)|ensembl:ENSMUST00000188371(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0016604"(nuclear body)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0051301"(cell division)|go:"GO:0005654"(nucleoplasm)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904792"(positive regulation of shelterin complex assembly)|go:"GO:1904850"(negative regulation of establishment of protein localization to telomere)|go:"GO:1904911"(negative regulation of establishment of RNA localization to telomere)|go:"GO:1905778"(negative regulation of exonuclease activity)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR036507|mint:P70371|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|reactome:R-MMU-9670095|refseq:NP_033378.1|dip:DIP-44231N	ensembl:ENSMUSG00000036875(gene)|ensembl:ENSMUST00000131422(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005760"(gamma DNA polymerase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0016890"(site-specific endodeoxyribonuclease activity, specific for altered base)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0033567"(DNA replication, Okazaki fragment processing)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043137"(DNA replication, removal of RNA primer)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0071932"(replication fork reversal)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR014808(DNA replication factor Dna2)|interpro:IPR026851|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|rcsb pdb:5EAN|rcsb pdb:5EAW|rcsb pdb:5EAX|reactome:R-MMU-174437|reactome:R-MMU-5685938|reactome:R-MMU-5685942|reactome:R-MMU-5693568|reactome:R-MMU-5693579|reactome:R-MMU-5693607|reactome:R-MMU-5693616|reactome:R-MMU-6804756|reactome:R-MMU-69166|reactome:R-MMU-69473|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|refseq:NP_796346.2	-	-	-	figure legend:f2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/08/06	2014/10/16	rogid:jpK0DXdrNcuBqR96dkp45t/W5+M10090	rogid:nmSdS6nCyZp5luxz+J3MOYCnr3I10090	intact-crc:32B56DC10471F525|rigid:99Ve4WAr/+GotCPpatjAP5wHWEc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6ZQJ5	uniprotkb:P70371	intact:EBI-6919222|ensembl:ENSMUSP00000115750|uniprotkb:Q14BM9|uniprotkb:Q8BSZ0|uniprotkb:Q8R3J3	intact:EBI-6919183|ensembl:ENSMUSP00000140744|uniprotkb:Q9CY71	psi-mi:dna2_mouse(display_long)|uniprotkb:Dna2(gene name)|psi-mi:Dna2(display_short)|uniprotkb:Dna2l(gene name synonym)|uniprotkb:Kiaa0083(gene name synonym)|uniprotkb:DNA replication ATP-dependent helicase-like homolog(gene name synonym)	psi-mi:terf1_mouse(display_long)|uniprotkb:Terf1(gene name)|psi-mi:Terf1(display_short)|uniprotkb:Trf1(gene name synonym)|uniprotkb:TTAGGG repeat-binding factor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lin et al. (2013)	pubmed:23604072|imex:IM-21125	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6919297|imex:IM-21125-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000036875(gene)|ensembl:ENSMUST00000131422(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005760"(gamma DNA polymerase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0016890"(site-specific endodeoxyribonuclease activity, specific for altered base)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0033567"(DNA replication, Okazaki fragment processing)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043137"(DNA replication, removal of RNA primer)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0071932"(replication fork reversal)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR014808(DNA replication factor Dna2)|interpro:IPR026851|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|rcsb pdb:5EAN|rcsb pdb:5EAW|rcsb pdb:5EAX|reactome:R-MMU-174437|reactome:R-MMU-5685938|reactome:R-MMU-5685942|reactome:R-MMU-5693568|reactome:R-MMU-5693579|reactome:R-MMU-5693607|reactome:R-MMU-5693616|reactome:R-MMU-6804756|reactome:R-MMU-69166|reactome:R-MMU-69473|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|refseq:NP_796346.2	ensembl:ENSMUSG00000025925(gene)|ensembl:ENSMUST00000188371(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0016604"(nuclear body)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0051301"(cell division)|go:"GO:0005654"(nucleoplasm)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904792"(positive regulation of shelterin complex assembly)|go:"GO:1904850"(negative regulation of establishment of protein localization to telomere)|go:"GO:1904911"(negative regulation of establishment of RNA localization to telomere)|go:"GO:1905778"(negative regulation of exonuclease activity)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR036507|mint:P70371|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|reactome:R-MMU-9670095|refseq:NP_033378.1|dip:DIP-44231N	-	-	-	figure legend:f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/08/06	2014/10/16	rogid:nmSdS6nCyZp5luxz+J3MOYCnr3I10090	rogid:jpK0DXdrNcuBqR96dkp45t/W5+M10090	intact-crc:073EC534B4302295|rigid:99Ve4WAr/+GotCPpatjAP5wHWEc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6ZQJ5	uniprotkb:O35144	intact:EBI-6919222|ensembl:ENSMUSP00000115750|uniprotkb:Q14BM9|uniprotkb:Q8BSZ0|uniprotkb:Q8R3J3	intact:EBI-6919263|ensembl:ENSMUSP00000068948|uniprotkb:D3YVG5|uniprotkb:Q80VE2|uniprotkb:Q8BQJ9	psi-mi:dna2_mouse(display_long)|uniprotkb:Dna2(gene name)|psi-mi:Dna2(display_short)|uniprotkb:Dna2l(gene name synonym)|uniprotkb:Kiaa0083(gene name synonym)|uniprotkb:DNA replication ATP-dependent helicase-like homolog(gene name synonym)	psi-mi:terf2_mouse(display_long)|uniprotkb:Terf2(gene name)|psi-mi:Terf2(display_short)|uniprotkb:Trf2(gene name synonym)|uniprotkb:TTAGGG repeat-binding factor 2(gene name synonym)|uniprotkb:Telomeric DNA-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lin et al. (2013)	pubmed:23604072|imex:IM-21125	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6919301|imex:IM-21125-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000036875(gene)|ensembl:ENSMUST00000131422(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005760"(gamma DNA polymerase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0016890"(site-specific endodeoxyribonuclease activity, specific for altered base)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0033567"(DNA replication, Okazaki fragment processing)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043137"(DNA replication, removal of RNA primer)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0071932"(replication fork reversal)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR014808(DNA replication factor Dna2)|interpro:IPR026851|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|rcsb pdb:5EAN|rcsb pdb:5EAW|rcsb pdb:5EAX|reactome:R-MMU-174437|reactome:R-MMU-5685938|reactome:R-MMU-5685942|reactome:R-MMU-5693568|reactome:R-MMU-5693579|reactome:R-MMU-5693607|reactome:R-MMU-5693616|reactome:R-MMU-6804756|reactome:R-MMU-69166|reactome:R-MMU-69473|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|refseq:NP_796346.2	refseq:NP_001273129.1|refseq:XP_006530899.1|ensembl:ENSMUSG00000031921(gene)|ensembl:ENSMUST00000068421(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031627"(telomeric loop formation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032208"(negative regulation of telomere maintenance via recombination)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0000723"(telomere maintenance)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:0099087"(anterograde axonal transport of messenger ribonucleoprotein complex)|go:"GO:1903770"(negative regulation of beta-galactosidase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904354"(negative regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR030657|interpro:IPR031902|interpro:IPR036507|mint:O35144|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095|go:"GO:0044877"(protein-containing complex binding)|refseq:NP_001076587.1	-	-	-	figure legend:f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/08/06	2014/10/16	rogid:nmSdS6nCyZp5luxz+J3MOYCnr3I10090	rogid:m2J9ZCnP5jMyGlT41WK3HqacWvA10090	intact-crc:FB37327D023E614D|rigid:CqEtyiTYjc8aKcehDD2wnF+lqjI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6ZQJ5	uniprotkb:O35144	intact:EBI-6919222|ensembl:ENSMUSP00000115750|uniprotkb:Q14BM9|uniprotkb:Q8BSZ0|uniprotkb:Q8R3J3	intact:EBI-6919263|ensembl:ENSMUSP00000068948|uniprotkb:D3YVG5|uniprotkb:Q80VE2|uniprotkb:Q8BQJ9	psi-mi:dna2_mouse(display_long)|uniprotkb:Dna2(gene name)|psi-mi:Dna2(display_short)|uniprotkb:Dna2l(gene name synonym)|uniprotkb:Kiaa0083(gene name synonym)|uniprotkb:DNA replication ATP-dependent helicase-like homolog(gene name synonym)	psi-mi:terf2_mouse(display_long)|uniprotkb:Terf2(gene name)|psi-mi:Terf2(display_short)|uniprotkb:Trf2(gene name synonym)|uniprotkb:TTAGGG repeat-binding factor 2(gene name synonym)|uniprotkb:Telomeric DNA-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lin et al. (2013)	pubmed:23604072|imex:IM-21125	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6919261|imex:IM-21125-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000036875(gene)|ensembl:ENSMUST00000131422(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005760"(gamma DNA polymerase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0016890"(site-specific endodeoxyribonuclease activity, specific for altered base)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0033567"(DNA replication, Okazaki fragment processing)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043137"(DNA replication, removal of RNA primer)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0071932"(replication fork reversal)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR014808(DNA replication factor Dna2)|interpro:IPR026851|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|rcsb pdb:5EAN|rcsb pdb:5EAW|rcsb pdb:5EAX|reactome:R-MMU-174437|reactome:R-MMU-5685938|reactome:R-MMU-5685942|reactome:R-MMU-5693568|reactome:R-MMU-5693579|reactome:R-MMU-5693607|reactome:R-MMU-5693616|reactome:R-MMU-6804756|reactome:R-MMU-69166|reactome:R-MMU-69473|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|refseq:NP_796346.2	refseq:NP_001273129.1|refseq:XP_006530899.1|ensembl:ENSMUSG00000031921(gene)|ensembl:ENSMUST00000068421(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031627"(telomeric loop formation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032208"(negative regulation of telomere maintenance via recombination)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0000723"(telomere maintenance)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:0099087"(anterograde axonal transport of messenger ribonucleoprotein complex)|go:"GO:1903770"(negative regulation of beta-galactosidase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904354"(negative regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR030657|interpro:IPR031902|interpro:IPR036507|mint:O35144|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095|go:"GO:0044877"(protein-containing complex binding)|refseq:NP_001076587.1	-	-	-	figure legend:f2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/08/06	2014/10/16	rogid:nmSdS6nCyZp5luxz+J3MOYCnr3I10090	rogid:m2J9ZCnP5jMyGlT41WK3HqacWvA10090	intact-crc:CEBE4A88B27FB6FD|rigid:CqEtyiTYjc8aKcehDD2wnF+lqjI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O35144	uniprotkb:Q6ZQJ5	intact:EBI-6919263|ensembl:ENSMUSP00000068948|uniprotkb:D3YVG5|uniprotkb:Q80VE2|uniprotkb:Q8BQJ9	intact:EBI-6919222|ensembl:ENSMUSP00000115750|uniprotkb:Q14BM9|uniprotkb:Q8BSZ0|uniprotkb:Q8R3J3	psi-mi:terf2_mouse(display_long)|uniprotkb:Terf2(gene name)|psi-mi:Terf2(display_short)|uniprotkb:Trf2(gene name synonym)|uniprotkb:TTAGGG repeat-binding factor 2(gene name synonym)|uniprotkb:Telomeric DNA-binding protein(gene name synonym)	psi-mi:dna2_mouse(display_long)|uniprotkb:Dna2(gene name)|psi-mi:Dna2(display_short)|uniprotkb:Dna2l(gene name synonym)|uniprotkb:Kiaa0083(gene name synonym)|uniprotkb:DNA replication ATP-dependent helicase-like homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lin et al. (2013)	pubmed:23604072|imex:IM-21125	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6919314|imex:IM-21125-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273129.1|refseq:XP_006530899.1|ensembl:ENSMUSG00000031921(gene)|ensembl:ENSMUST00000068421(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031627"(telomeric loop formation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032208"(negative regulation of telomere maintenance via recombination)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0000723"(telomere maintenance)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:0099087"(anterograde axonal transport of messenger ribonucleoprotein complex)|go:"GO:1903770"(negative regulation of beta-galactosidase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904354"(negative regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR030657|interpro:IPR031902|interpro:IPR036507|mint:O35144|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095|go:"GO:0044877"(protein-containing complex binding)|refseq:NP_001076587.1	ensembl:ENSMUSG00000036875(gene)|ensembl:ENSMUST00000131422(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005760"(gamma DNA polymerase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0016890"(site-specific endodeoxyribonuclease activity, specific for altered base)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0033567"(DNA replication, Okazaki fragment processing)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043137"(DNA replication, removal of RNA primer)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0071932"(replication fork reversal)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR014808(DNA replication factor Dna2)|interpro:IPR026851|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|rcsb pdb:5EAN|rcsb pdb:5EAW|rcsb pdb:5EAX|reactome:R-MMU-174437|reactome:R-MMU-5685938|reactome:R-MMU-5685942|reactome:R-MMU-5693568|reactome:R-MMU-5693579|reactome:R-MMU-5693607|reactome:R-MMU-5693616|reactome:R-MMU-6804756|reactome:R-MMU-69166|reactome:R-MMU-69473|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|refseq:NP_796346.2	-	-	-	figure legend:f2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/08/06	2014/10/16	rogid:m2J9ZCnP5jMyGlT41WK3HqacWvA10090	rogid:nmSdS6nCyZp5luxz+J3MOYCnr3I10090	intact-crc:7FA8CA88B2B53A8C|rigid:CqEtyiTYjc8aKcehDD2wnF+lqjI	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P70371	uniprotkb:Q6ZQJ5	intact:EBI-6919183|ensembl:ENSMUSP00000140744|uniprotkb:Q9CY71	intact:EBI-6919222|ensembl:ENSMUSP00000115750|uniprotkb:Q14BM9|uniprotkb:Q8BSZ0|uniprotkb:Q8R3J3	psi-mi:terf1_mouse(display_long)|uniprotkb:Terf1(gene name)|psi-mi:Terf1(display_short)|uniprotkb:Trf1(gene name synonym)|uniprotkb:TTAGGG repeat-binding factor 1(gene name synonym)	psi-mi:dna2_mouse(display_long)|uniprotkb:Dna2(gene name)|psi-mi:Dna2(display_short)|uniprotkb:Dna2l(gene name synonym)|uniprotkb:Kiaa0083(gene name synonym)|uniprotkb:DNA replication ATP-dependent helicase-like homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lin et al. (2013)	pubmed:23604072|imex:IM-21125	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6919322|imex:IM-21125-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025925(gene)|ensembl:ENSMUST00000188371(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0016604"(nuclear body)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0051301"(cell division)|go:"GO:0005654"(nucleoplasm)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904792"(positive regulation of shelterin complex assembly)|go:"GO:1904850"(negative regulation of establishment of protein localization to telomere)|go:"GO:1904911"(negative regulation of establishment of RNA localization to telomere)|go:"GO:1905778"(negative regulation of exonuclease activity)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR036507|mint:P70371|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|reactome:R-MMU-9670095|refseq:NP_033378.1|dip:DIP-44231N	ensembl:ENSMUSG00000036875(gene)|ensembl:ENSMUST00000131422(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005760"(gamma DNA polymerase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0016890"(site-specific endodeoxyribonuclease activity, specific for altered base)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0033567"(DNA replication, Okazaki fragment processing)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043137"(DNA replication, removal of RNA primer)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0071932"(replication fork reversal)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR014808(DNA replication factor Dna2)|interpro:IPR026851|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|rcsb pdb:5EAN|rcsb pdb:5EAW|rcsb pdb:5EAX|reactome:R-MMU-174437|reactome:R-MMU-5685938|reactome:R-MMU-5685942|reactome:R-MMU-5693568|reactome:R-MMU-5693579|reactome:R-MMU-5693607|reactome:R-MMU-5693616|reactome:R-MMU-6804756|reactome:R-MMU-69166|reactome:R-MMU-69473|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|refseq:NP_796346.2	-	-	-	figure legend:f2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/08/06	2014/10/16	rogid:jpK0DXdrNcuBqR96dkp45t/W5+M10090	rogid:nmSdS6nCyZp5luxz+J3MOYCnr3I10090	intact-crc:117EDC0A850C2EE6|rigid:99Ve4WAr/+GotCPpatjAP5wHWEc	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P70371	uniprotkb:Q6ZQJ5	intact:EBI-6919183|ensembl:ENSMUSP00000140744|uniprotkb:Q9CY71	intact:EBI-6919222|ensembl:ENSMUSP00000115750|uniprotkb:Q14BM9|uniprotkb:Q8BSZ0|uniprotkb:Q8R3J3	psi-mi:terf1_mouse(display_long)|uniprotkb:Terf1(gene name)|psi-mi:Terf1(display_short)|uniprotkb:Trf1(gene name synonym)|uniprotkb:TTAGGG repeat-binding factor 1(gene name synonym)	psi-mi:dna2_mouse(display_long)|uniprotkb:Dna2(gene name)|psi-mi:Dna2(display_short)|uniprotkb:Dna2l(gene name synonym)|uniprotkb:Kiaa0083(gene name synonym)|uniprotkb:DNA replication ATP-dependent helicase-like homolog(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Lin et al. (2013)	pubmed:23604072|imex:IM-21125	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-6919337|imex:IM-21125-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025925(gene)|ensembl:ENSMUST00000188371(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0016604"(nuclear body)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0051301"(cell division)|go:"GO:0005654"(nucleoplasm)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904792"(positive regulation of shelterin complex assembly)|go:"GO:1904850"(negative regulation of establishment of protein localization to telomere)|go:"GO:1904911"(negative regulation of establishment of RNA localization to telomere)|go:"GO:1905778"(negative regulation of exonuclease activity)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR036507|mint:P70371|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|reactome:R-MMU-9670095|refseq:NP_033378.1|dip:DIP-44231N	ensembl:ENSMUSG00000036875(gene)|ensembl:ENSMUST00000131422(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005760"(gamma DNA polymerase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0016890"(site-specific endodeoxyribonuclease activity, specific for altered base)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0033567"(DNA replication, Okazaki fragment processing)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043137"(DNA replication, removal of RNA primer)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0071932"(replication fork reversal)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR014808(DNA replication factor Dna2)|interpro:IPR026851|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|rcsb pdb:5EAN|rcsb pdb:5EAW|rcsb pdb:5EAX|reactome:R-MMU-174437|reactome:R-MMU-5685938|reactome:R-MMU-5685942|reactome:R-MMU-5693568|reactome:R-MMU-5693579|reactome:R-MMU-5693607|reactome:R-MMU-5693616|reactome:R-MMU-6804756|reactome:R-MMU-69166|reactome:R-MMU-69473|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|refseq:NP_796346.2	go:"GO:0005696"(obsolete telomere)	-	-	figure legend:f2f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/08/06	2014/10/16	rogid:jpK0DXdrNcuBqR96dkp45t/W5+M10090	rogid:nmSdS6nCyZp5luxz+J3MOYCnr3I10090	intact-crc:9E6F1A119DBFE7A5|rigid:99Ve4WAr/+GotCPpatjAP5wHWEc	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q6ZQJ5	uniprotkb:O35144	intact:EBI-6919222|ensembl:ENSMUSP00000115750|uniprotkb:Q14BM9|uniprotkb:Q8BSZ0|uniprotkb:Q8R3J3	intact:EBI-6919263|ensembl:ENSMUSP00000068948|uniprotkb:D3YVG5|uniprotkb:Q80VE2|uniprotkb:Q8BQJ9	psi-mi:dna2_mouse(display_long)|uniprotkb:Dna2(gene name)|psi-mi:Dna2(display_short)|uniprotkb:Dna2l(gene name synonym)|uniprotkb:Kiaa0083(gene name synonym)|uniprotkb:DNA replication ATP-dependent helicase-like homolog(gene name synonym)	psi-mi:terf2_mouse(display_long)|uniprotkb:Terf2(gene name)|psi-mi:Terf2(display_short)|uniprotkb:Trf2(gene name synonym)|uniprotkb:TTAGGG repeat-binding factor 2(gene name synonym)|uniprotkb:Telomeric DNA-binding protein(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Lin et al. (2013)	pubmed:23604072|imex:IM-21125	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-6919343|imex:IM-21125-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000036875(gene)|ensembl:ENSMUST00000131422(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005760"(gamma DNA polymerase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0016890"(site-specific endodeoxyribonuclease activity, specific for altered base)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0033567"(DNA replication, Okazaki fragment processing)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043137"(DNA replication, removal of RNA primer)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0071932"(replication fork reversal)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR014808(DNA replication factor Dna2)|interpro:IPR026851|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|rcsb pdb:5EAN|rcsb pdb:5EAW|rcsb pdb:5EAX|reactome:R-MMU-174437|reactome:R-MMU-5685938|reactome:R-MMU-5685942|reactome:R-MMU-5693568|reactome:R-MMU-5693579|reactome:R-MMU-5693607|reactome:R-MMU-5693616|reactome:R-MMU-6804756|reactome:R-MMU-69166|reactome:R-MMU-69473|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|refseq:NP_796346.2	refseq:NP_001273129.1|refseq:XP_006530899.1|ensembl:ENSMUSG00000031921(gene)|ensembl:ENSMUST00000068421(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031627"(telomeric loop formation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032208"(negative regulation of telomere maintenance via recombination)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0000723"(telomere maintenance)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:0099087"(anterograde axonal transport of messenger ribonucleoprotein complex)|go:"GO:1903770"(negative regulation of beta-galactosidase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904354"(negative regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR030657|interpro:IPR031902|interpro:IPR036507|mint:O35144|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-171319|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174430|reactome:R-MMU-174437|reactome:R-MMU-2559586|reactome:R-MMU-9670095|go:"GO:0044877"(protein-containing complex binding)|refseq:NP_001076587.1	go:"GO:0005696"(obsolete telomere)	-	-	figure legend:f2f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2013/08/06	2014/10/16	rogid:nmSdS6nCyZp5luxz+J3MOYCnr3I10090	rogid:m2J9ZCnP5jMyGlT41WK3HqacWvA10090	intact-crc:6266ED582BB1A47D|rigid:CqEtyiTYjc8aKcehDD2wnF+lqjI	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)