#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P14780	uniprotkb:P14780	intact:EBI-1382326|uniprotkb:Q3LR70|uniprotkb:Q8N725|uniprotkb:Q9H4Z1|uniprotkb:B2R7V9|uniprotkb:Q9UCJ9|uniprotkb:Q9UCL1|uniprotkb:Q9UDK2|ensembl:ENSP00000361405	intact:EBI-1382326|uniprotkb:Q3LR70|uniprotkb:Q8N725|uniprotkb:Q9H4Z1|uniprotkb:B2R7V9|uniprotkb:Q9UCJ9|uniprotkb:Q9UCL1|uniprotkb:Q9UDK2|ensembl:ENSP00000361405	psi-mi:mmp9_human(display_long)|uniprotkb:MMP9(gene name)|psi-mi:MMP9(display_short)|uniprotkb:CLG4B(gene name synonym)|uniprotkb:92 kDa type IV collagenase(gene name synonym)|uniprotkb:92 kDa gelatinase(gene name synonym)|uniprotkb:Gelatinase B(gene name synonym)	psi-mi:mmp9_human(display_long)|uniprotkb:MMP9(gene name)|psi-mi:MMP9(display_short)|uniprotkb:CLG4B(gene name synonym)|uniprotkb:92 kDa type IV collagenase(gene name synonym)|uniprotkb:92 kDa gelatinase(gene name synonym)|uniprotkb:Gelatinase B(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Malla et al. (2013)	mint:fj-13-0162|pubmed:23601700|mint:MINT-8426754	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8515964|mint:MINT-8426759	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004985.2|dip:DIP-29518N|ensembl:ENSG00000100985(gene)|ensembl:ENST00000372330(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007566"(embryo implantation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000697"(negative regulation of epithelial cell differentiation involved in kidney development)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001258"(negative regulation of cation channel activity)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028688|interpro:IPR033739|go:"GO:1900122"(positive regulation of receptor binding)|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|mint:P14780|rcsb pdb:1GKC|rcsb pdb:1GKD|rcsb pdb:1ITV|rcsb pdb:1L6J|rcsb pdb:1LKG|rcsb pdb:2OVX|rcsb pdb:2OVZ|rcsb pdb:2OW0|rcsb pdb:2OW1|rcsb pdb:2OW2|rcsb pdb:4H1Q|rcsb pdb:4H2E|rcsb pdb:4H3X|rcsb pdb:4H82|rcsb pdb:4HMA|rcsb pdb:4JIJ|rcsb pdb:4JQG|rcsb pdb:4WZV|rcsb pdb:4XCT|rcsb pdb:5CUH|rcsb pdb:5I12|rcsb pdb:5TH6|rcsb pdb:5TH9|rcsb pdb:5UE3|rcsb pdb:5UE4|rcsb pdb:6ESM|reactome:R-HSA-1433557|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-2022090|reactome:R-HSA-3928665|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-9009391|mint:MINT-8426761(identity)	refseq:NP_004985.2|dip:DIP-29518N|ensembl:ENSG00000100985(gene)|ensembl:ENST00000372330(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007566"(embryo implantation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000697"(negative regulation of epithelial cell differentiation involved in kidney development)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001258"(negative regulation of cation channel activity)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028688|interpro:IPR033739|go:"GO:1900122"(positive regulation of receptor binding)|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|mint:P14780|rcsb pdb:1GKC|rcsb pdb:1GKD|rcsb pdb:1ITV|rcsb pdb:1L6J|rcsb pdb:1LKG|rcsb pdb:2OVX|rcsb pdb:2OVZ|rcsb pdb:2OW0|rcsb pdb:2OW1|rcsb pdb:2OW2|rcsb pdb:4H1Q|rcsb pdb:4H2E|rcsb pdb:4H3X|rcsb pdb:4H82|rcsb pdb:4HMA|rcsb pdb:4JIJ|rcsb pdb:4JQG|rcsb pdb:4WZV|rcsb pdb:4XCT|rcsb pdb:5CUH|rcsb pdb:5I12|rcsb pdb:5TH6|rcsb pdb:5TH9|rcsb pdb:5UE3|rcsb pdb:5UE4|rcsb pdb:6ESM|reactome:R-HSA-1433557|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-2022090|reactome:R-HSA-3928665|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-9009391|mint:MINT-8426761(identity)	-	comment:"Stoichiometry: 2.0"	comment:"Stoichiometry: 2.0"	figure legend:f6a|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/16	2014/10/16	rogid:0PnzH1KPp4SKRWfRGotPA2eSHZk9606	rogid:0PnzH1KPp4SKRWfRGotPA2eSHZk9606	intact-crc:AD5DE098F604C13B|rigid:TqurVww3k85CpbsLs4elapTeJBQ	false	-	-	2	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13611	uniprotkb:P14780	intact:EBI-8515977|intact:MINT-4529155|uniprotkb:Q15123|uniprotkb:P20754|uniprotkb:Q9UNW5|uniprotkb:Q13189|uniprotkb:Q13010|uniprotkb:Q9UCL9|ensembl:ENSP00000265077	intact:EBI-1382326|uniprotkb:Q3LR70|uniprotkb:Q8N725|uniprotkb:Q9H4Z1|uniprotkb:B2R7V9|uniprotkb:Q9UCJ9|uniprotkb:Q9UCL1|uniprotkb:Q9UDK2|ensembl:ENSP00000361405	psi-mi:cspg2_human(display_long)|uniprotkb:VCAN(gene name)|psi-mi:VCAN(display_short)|uniprotkb:CSPG2(gene name synonym)|uniprotkb:Large fibroblast proteoglycan(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan core protein 2(gene name synonym)|uniprotkb:PG-M(gene name synonym)|uniprotkb:Glial hyaluronate-binding protein(gene name synonym)	psi-mi:mmp9_human(display_long)|uniprotkb:MMP9(gene name)|psi-mi:MMP9(display_short)|uniprotkb:CLG4B(gene name synonym)|uniprotkb:92 kDa type IV collagenase(gene name synonym)|uniprotkb:92 kDa gelatinase(gene name synonym)|uniprotkb:Gelatinase B(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Malla et al. (2013)	mint:fj-13-0162|pubmed:23601700|mint:MINT-8426754	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8515972|mint:MINT-8427508	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119808.1|refseq:NP_001157569.1|refseq:NP_001157570.1|refseq:NP_004376.2|ensembl:ENSG00000038427(gene)|ensembl:ENST00000265077(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007417"(central nervous system development)|go:"GO:0008037"(cell recognition)|go:"GO:0008347"(glial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033165"(interphotoreceptor matrix)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000538(Link)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018097|interpro:IPR018378|interpro:IPR033987|interpro:IPR035976|interpro:IPR036179|mint:P13611|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-381426|reactome:R-HSA-4420332|reactome:R-HSA-8957275|mint:MINT-8427517(identity)	refseq:NP_004985.2|dip:DIP-29518N|ensembl:ENSG00000100985(gene)|ensembl:ENST00000372330(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007566"(embryo implantation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000697"(negative regulation of epithelial cell differentiation involved in kidney development)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001258"(negative regulation of cation channel activity)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028688|interpro:IPR033739|go:"GO:1900122"(positive regulation of receptor binding)|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|mint:P14780|rcsb pdb:1GKC|rcsb pdb:1GKD|rcsb pdb:1ITV|rcsb pdb:1L6J|rcsb pdb:1LKG|rcsb pdb:2OVX|rcsb pdb:2OVZ|rcsb pdb:2OW0|rcsb pdb:2OW1|rcsb pdb:2OW2|rcsb pdb:4H1Q|rcsb pdb:4H2E|rcsb pdb:4H3X|rcsb pdb:4H82|rcsb pdb:4HMA|rcsb pdb:4JIJ|rcsb pdb:4JQG|rcsb pdb:4WZV|rcsb pdb:4XCT|rcsb pdb:5CUH|rcsb pdb:5I12|rcsb pdb:5TH6|rcsb pdb:5TH9|rcsb pdb:5UE3|rcsb pdb:5UE4|rcsb pdb:6ESM|reactome:R-HSA-1433557|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-2022090|reactome:R-HSA-3928665|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-9009391|mint:MINT-8427510(identity)	-	comment:mint|comment:homomint|function:May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid|function:"Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1) [MIM:143200]. WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN"	-	figure legend:f6a|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/16	2014/10/16	rogid:hnqTxboVu1BtuxYP2jENLXXZqcQ9606	rogid:0PnzH1KPp4SKRWfRGotPA2eSHZk9606	intact-crc:9990BA286A3080F9|rigid:PQiuaLZRohuV1CsQhuEYkNu7UZE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13611	uniprotkb:P10124	intact:EBI-8515977|intact:MINT-4529155|uniprotkb:Q15123|uniprotkb:P20754|uniprotkb:Q9UNW5|uniprotkb:Q13189|uniprotkb:Q13010|uniprotkb:Q9UCL9|ensembl:ENSP00000265077	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:cspg2_human(display_long)|uniprotkb:VCAN(gene name)|psi-mi:VCAN(display_short)|uniprotkb:CSPG2(gene name synonym)|uniprotkb:Large fibroblast proteoglycan(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan core protein 2(gene name synonym)|uniprotkb:PG-M(gene name synonym)|uniprotkb:Glial hyaluronate-binding protein(gene name synonym)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Malla et al. (2013)	mint:fj-13-0162|pubmed:23601700|mint:MINT-8426754	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8515972|mint:MINT-8427508	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119808.1|refseq:NP_001157569.1|refseq:NP_001157570.1|refseq:NP_004376.2|ensembl:ENSG00000038427(gene)|ensembl:ENST00000265077(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007417"(central nervous system development)|go:"GO:0008037"(cell recognition)|go:"GO:0008347"(glial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033165"(interphotoreceptor matrix)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000538(Link)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018097|interpro:IPR018378|interpro:IPR033987|interpro:IPR035976|interpro:IPR036179|mint:P13611|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-381426|reactome:R-HSA-4420332|reactome:R-HSA-8957275|mint:MINT-8427517(identity)	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1|mint:MINT-8427512(identity)	-	comment:mint|comment:homomint|function:May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid|function:"Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1) [MIM:143200]. WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN"	-	figure legend:f6a|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/16	2014/10/16	rogid:hnqTxboVu1BtuxYP2jENLXXZqcQ9606	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	intact-crc:9990BA286A3080F9|rigid:PQiuaLZRohuV1CsQhuEYkNu7UZE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P59807	uniprotkb:P10124	intact:EBI-8516052|uniprotkb:D0V0C9|intact:MINT-8427450	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:cabc1_provu(display_long)|uniprotkb:Chondroitin ABC endoeliminase(gene name synonym)|uniprotkb:Chondroitin ABC lyase I(gene name synonym)|uniprotkb:Chondroitin sulfate ABC lyase I(gene name synonym)|uniprotkb:Chondroitinase ABC I(gene name synonym)|uniprotkb:Endochondroitinase ABC(gene name synonym)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Malla et al. (2013)	mint:fj-13-0162|pubmed:23601700|mint:MINT-8426754	taxid:585(provu)|taxid:585(Proteus vulgaris)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8516092|mint:MINT-8427533	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR024200|interpro:IPR008979(Galactose-binding like)|interpro:IPR011071(Polysaccharide lyase family 8-like, C-terminal)|interpro:IPR014718(Glycoside hydrolase-type carbohydrate-binding, subgroup)|interpro:IPR008929(Chondroitin AC/alginate lyase)|interpro:IPR004103(Polysaccharide lyase family 8, C-terminal)|interpro:IPR015176(Lyase, N terminal)|interpro:IPR003159(Polysaccharide lyase family 8, central)|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)|interpro:IPR015177(Lyase, catalytic)|mint:P59807|interpro:IPR039174|go:"GO:0005576"(extracellular region)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006027"(glycosaminoglycan catabolic process)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0034000"(chondroitin-sulfate-ABC endolyase activity)|go:"GO:0042597"(periplasmic space)|go:"GO:0046872"(metal ion binding)|rcsb pdb:1HN0|mint:MINT-8427535(identity)	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1|mint:MINT-8427537(identity)	-	comment:mint	-	figure legend:f4b|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/16	2014/10/16	rogid:EjAoI3sT9yI7ToA8shQtzQDf/UI585	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	intact-crc:CE5E77CDE7DFD401|rigid:+k4RP67EK++OHc6g1Zbur6E3nYc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13611	uniprotkb:P59807	intact:EBI-8515977|intact:MINT-4529155|uniprotkb:Q15123|uniprotkb:P20754|uniprotkb:Q9UNW5|uniprotkb:Q13189|uniprotkb:Q13010|uniprotkb:Q9UCL9|ensembl:ENSP00000265077	intact:EBI-8516052|uniprotkb:D0V0C9|intact:MINT-8427450	psi-mi:cspg2_human(display_long)|uniprotkb:VCAN(gene name)|psi-mi:VCAN(display_short)|uniprotkb:CSPG2(gene name synonym)|uniprotkb:Large fibroblast proteoglycan(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan core protein 2(gene name synonym)|uniprotkb:PG-M(gene name synonym)|uniprotkb:Glial hyaluronate-binding protein(gene name synonym)	psi-mi:cabc1_provu(display_long)|uniprotkb:Chondroitin ABC endoeliminase(gene name synonym)|uniprotkb:Chondroitin ABC lyase I(gene name synonym)|uniprotkb:Chondroitin sulfate ABC lyase I(gene name synonym)|uniprotkb:Chondroitinase ABC I(gene name synonym)|uniprotkb:Endochondroitinase ABC(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Malla et al. (2013)	mint:fj-13-0162|pubmed:23601700|mint:MINT-8426754	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:585(provu)|taxid:585(Proteus vulgaris)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8516082|mint:MINT-8427520	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119808.1|refseq:NP_001157569.1|refseq:NP_001157570.1|refseq:NP_004376.2|ensembl:ENSG00000038427(gene)|ensembl:ENST00000265077(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007417"(central nervous system development)|go:"GO:0008037"(cell recognition)|go:"GO:0008347"(glial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033165"(interphotoreceptor matrix)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000538(Link)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018097|interpro:IPR018378|interpro:IPR033987|interpro:IPR035976|interpro:IPR036179|mint:P13611|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-381426|reactome:R-HSA-4420332|reactome:R-HSA-8957275|mint:MINT-8427524(identity)	interpro:IPR024200|interpro:IPR008979(Galactose-binding like)|interpro:IPR011071(Polysaccharide lyase family 8-like, C-terminal)|interpro:IPR014718(Glycoside hydrolase-type carbohydrate-binding, subgroup)|interpro:IPR008929(Chondroitin AC/alginate lyase)|interpro:IPR004103(Polysaccharide lyase family 8, C-terminal)|interpro:IPR015176(Lyase, N terminal)|interpro:IPR003159(Polysaccharide lyase family 8, central)|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)|interpro:IPR015177(Lyase, catalytic)|mint:P59807|interpro:IPR039174|go:"GO:0005576"(extracellular region)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006027"(glycosaminoglycan catabolic process)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0034000"(chondroitin-sulfate-ABC endolyase activity)|go:"GO:0042597"(periplasmic space)|go:"GO:0046872"(metal ion binding)|rcsb pdb:1HN0|mint:MINT-8427522(identity)	-	comment:mint|comment:homomint|function:May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid|function:"Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1) [MIM:143200]. WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN"	comment:mint	figure legend:f4a|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/16	2014/10/16	rogid:hnqTxboVu1BtuxYP2jENLXXZqcQ9606	rogid:EjAoI3sT9yI7ToA8shQtzQDf/UI585	intact-crc:1221DC5B921C3C0A|rigid:5AG3AFZVnq5Iz0Uq4jRGmHwXy9M	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14780	uniprotkb:P10124	intact:EBI-1382326|uniprotkb:Q3LR70|uniprotkb:Q8N725|uniprotkb:Q9H4Z1|uniprotkb:B2R7V9|uniprotkb:Q9UCJ9|uniprotkb:Q9UCL1|uniprotkb:Q9UDK2|ensembl:ENSP00000361405	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:mmp9_human(display_long)|uniprotkb:MMP9(gene name)|psi-mi:MMP9(display_short)|uniprotkb:CLG4B(gene name synonym)|uniprotkb:92 kDa type IV collagenase(gene name synonym)|uniprotkb:92 kDa gelatinase(gene name synonym)|uniprotkb:Gelatinase B(gene name synonym)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0512"(zymography)	Malla et al. (2013)	mint:fj-13-0162|pubmed:23601700|mint:MINT-8426754	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8516133|mint:MINT-8427486	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004985.2|dip:DIP-29518N|ensembl:ENSG00000100985(gene)|ensembl:ENST00000372330(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007566"(embryo implantation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000697"(negative regulation of epithelial cell differentiation involved in kidney development)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001258"(negative regulation of cation channel activity)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028688|interpro:IPR033739|go:"GO:1900122"(positive regulation of receptor binding)|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|mint:P14780|rcsb pdb:1GKC|rcsb pdb:1GKD|rcsb pdb:1ITV|rcsb pdb:1L6J|rcsb pdb:1LKG|rcsb pdb:2OVX|rcsb pdb:2OVZ|rcsb pdb:2OW0|rcsb pdb:2OW1|rcsb pdb:2OW2|rcsb pdb:4H1Q|rcsb pdb:4H2E|rcsb pdb:4H3X|rcsb pdb:4H82|rcsb pdb:4HMA|rcsb pdb:4JIJ|rcsb pdb:4JQG|rcsb pdb:4WZV|rcsb pdb:4XCT|rcsb pdb:5CUH|rcsb pdb:5I12|rcsb pdb:5TH6|rcsb pdb:5TH9|rcsb pdb:5UE3|rcsb pdb:5UE4|rcsb pdb:6ESM|reactome:R-HSA-1433557|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-2022090|reactome:R-HSA-3928665|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-9009391|mint:MINT-8427492(identity)	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1|mint:MINT-8427488(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f5c f5d	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/16	2014/10/16	rogid:0PnzH1KPp4SKRWfRGotPA2eSHZk9606	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	intact-crc:589DF75D69C5C9DB|rigid:x6EFZqxX5v9lRyNieWvhQy3RpU8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14780	uniprotkb:P14780	intact:EBI-1382326|uniprotkb:Q3LR70|uniprotkb:Q8N725|uniprotkb:Q9H4Z1|uniprotkb:B2R7V9|uniprotkb:Q9UCJ9|uniprotkb:Q9UCL1|uniprotkb:Q9UDK2|ensembl:ENSP00000361405	intact:EBI-1382326|uniprotkb:Q3LR70|uniprotkb:Q8N725|uniprotkb:Q9H4Z1|uniprotkb:B2R7V9|uniprotkb:Q9UCJ9|uniprotkb:Q9UCL1|uniprotkb:Q9UDK2|ensembl:ENSP00000361405	psi-mi:mmp9_human(display_long)|uniprotkb:MMP9(gene name)|psi-mi:MMP9(display_short)|uniprotkb:CLG4B(gene name synonym)|uniprotkb:92 kDa type IV collagenase(gene name synonym)|uniprotkb:92 kDa gelatinase(gene name synonym)|uniprotkb:Gelatinase B(gene name synonym)	psi-mi:mmp9_human(display_long)|uniprotkb:MMP9(gene name)|psi-mi:MMP9(display_short)|uniprotkb:CLG4B(gene name synonym)|uniprotkb:92 kDa type IV collagenase(gene name synonym)|uniprotkb:92 kDa gelatinase(gene name synonym)|uniprotkb:Gelatinase B(gene name synonym)	psi-mi:"MI:0512"(zymography)	Malla et al. (2013)	mint:fj-13-0162|pubmed:23601700|mint:MINT-8426754	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8516111|mint:MINT-8426766	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004985.2|dip:DIP-29518N|ensembl:ENSG00000100985(gene)|ensembl:ENST00000372330(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007566"(embryo implantation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000697"(negative regulation of epithelial cell differentiation involved in kidney development)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001258"(negative regulation of cation channel activity)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028688|interpro:IPR033739|go:"GO:1900122"(positive regulation of receptor binding)|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|mint:P14780|rcsb pdb:1GKC|rcsb pdb:1GKD|rcsb pdb:1ITV|rcsb pdb:1L6J|rcsb pdb:1LKG|rcsb pdb:2OVX|rcsb pdb:2OVZ|rcsb pdb:2OW0|rcsb pdb:2OW1|rcsb pdb:2OW2|rcsb pdb:4H1Q|rcsb pdb:4H2E|rcsb pdb:4H3X|rcsb pdb:4H82|rcsb pdb:4HMA|rcsb pdb:4JIJ|rcsb pdb:4JQG|rcsb pdb:4WZV|rcsb pdb:4XCT|rcsb pdb:5CUH|rcsb pdb:5I12|rcsb pdb:5TH6|rcsb pdb:5TH9|rcsb pdb:5UE3|rcsb pdb:5UE4|rcsb pdb:6ESM|reactome:R-HSA-1433557|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-2022090|reactome:R-HSA-3928665|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-9009391|mint:MINT-8426768(identity)	refseq:NP_004985.2|dip:DIP-29518N|ensembl:ENSG00000100985(gene)|ensembl:ENST00000372330(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007566"(embryo implantation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000697"(negative regulation of epithelial cell differentiation involved in kidney development)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001258"(negative regulation of cation channel activity)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028688|interpro:IPR033739|go:"GO:1900122"(positive regulation of receptor binding)|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|mint:P14780|rcsb pdb:1GKC|rcsb pdb:1GKD|rcsb pdb:1ITV|rcsb pdb:1L6J|rcsb pdb:1LKG|rcsb pdb:2OVX|rcsb pdb:2OVZ|rcsb pdb:2OW0|rcsb pdb:2OW1|rcsb pdb:2OW2|rcsb pdb:4H1Q|rcsb pdb:4H2E|rcsb pdb:4H3X|rcsb pdb:4H82|rcsb pdb:4HMA|rcsb pdb:4JIJ|rcsb pdb:4JQG|rcsb pdb:4WZV|rcsb pdb:4XCT|rcsb pdb:5CUH|rcsb pdb:5I12|rcsb pdb:5TH6|rcsb pdb:5TH9|rcsb pdb:5UE3|rcsb pdb:5UE4|rcsb pdb:6ESM|reactome:R-HSA-1433557|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-2022090|reactome:R-HSA-3928665|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-9009391|mint:MINT-8426768(identity)	-	comment:"Stoichiometry: 2.0"	comment:"Stoichiometry: 2.0"	comment:mint|figure legend:f1 f2  f3 f5c f5d f6b f6c f7 f8	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/16	2014/10/16	rogid:0PnzH1KPp4SKRWfRGotPA2eSHZk9606	rogid:0PnzH1KPp4SKRWfRGotPA2eSHZk9606	intact-crc:93E17F09F529D78C|rigid:TqurVww3k85CpbsLs4elapTeJBQ	false	-	-	2	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13611	uniprotkb:P14780	intact:EBI-8515977|intact:MINT-4529155|uniprotkb:Q15123|uniprotkb:P20754|uniprotkb:Q9UNW5|uniprotkb:Q13189|uniprotkb:Q13010|uniprotkb:Q9UCL9|ensembl:ENSP00000265077	intact:EBI-1382326|uniprotkb:Q3LR70|uniprotkb:Q8N725|uniprotkb:Q9H4Z1|uniprotkb:B2R7V9|uniprotkb:Q9UCJ9|uniprotkb:Q9UCL1|uniprotkb:Q9UDK2|ensembl:ENSP00000361405	psi-mi:cspg2_human(display_long)|uniprotkb:VCAN(gene name)|psi-mi:VCAN(display_short)|uniprotkb:CSPG2(gene name synonym)|uniprotkb:Large fibroblast proteoglycan(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan core protein 2(gene name synonym)|uniprotkb:PG-M(gene name synonym)|uniprotkb:Glial hyaluronate-binding protein(gene name synonym)	psi-mi:mmp9_human(display_long)|uniprotkb:MMP9(gene name)|psi-mi:MMP9(display_short)|uniprotkb:CLG4B(gene name synonym)|uniprotkb:92 kDa type IV collagenase(gene name synonym)|uniprotkb:92 kDa gelatinase(gene name synonym)|uniprotkb:Gelatinase B(gene name synonym)	psi-mi:"MI:0512"(zymography)	Malla et al. (2013)	mint:fj-13-0162|pubmed:23601700|mint:MINT-8426754	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8516119|mint:MINT-8427443	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119808.1|refseq:NP_001157569.1|refseq:NP_001157570.1|refseq:NP_004376.2|ensembl:ENSG00000038427(gene)|ensembl:ENST00000265077(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007417"(central nervous system development)|go:"GO:0008037"(cell recognition)|go:"GO:0008347"(glial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033165"(interphotoreceptor matrix)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000538(Link)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018097|interpro:IPR018378|interpro:IPR033987|interpro:IPR035976|interpro:IPR036179|mint:P13611|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-381426|reactome:R-HSA-4420332|reactome:R-HSA-8957275|mint:MINT-8427478(identity)	refseq:NP_004985.2|dip:DIP-29518N|ensembl:ENSG00000100985(gene)|ensembl:ENST00000372330(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007566"(embryo implantation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000697"(negative regulation of epithelial cell differentiation involved in kidney development)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001258"(negative regulation of cation channel activity)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028688|interpro:IPR033739|go:"GO:1900122"(positive regulation of receptor binding)|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|mint:P14780|rcsb pdb:1GKC|rcsb pdb:1GKD|rcsb pdb:1ITV|rcsb pdb:1L6J|rcsb pdb:1LKG|rcsb pdb:2OVX|rcsb pdb:2OVZ|rcsb pdb:2OW0|rcsb pdb:2OW1|rcsb pdb:2OW2|rcsb pdb:4H1Q|rcsb pdb:4H2E|rcsb pdb:4H3X|rcsb pdb:4H82|rcsb pdb:4HMA|rcsb pdb:4JIJ|rcsb pdb:4JQG|rcsb pdb:4WZV|rcsb pdb:4XCT|rcsb pdb:5CUH|rcsb pdb:5I12|rcsb pdb:5TH6|rcsb pdb:5TH9|rcsb pdb:5UE3|rcsb pdb:5UE4|rcsb pdb:6ESM|reactome:R-HSA-1433557|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-2022090|reactome:R-HSA-3928665|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-9009391|mint:MINT-8427445(identity)	-	comment:mint|comment:homomint|function:May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid|function:"Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1) [MIM:143200]. WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN"	-	comment:homomint|comment:mint|figure legend:f1 f2  f3 f6b f6c f7 f8	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/16	2014/10/16	rogid:hnqTxboVu1BtuxYP2jENLXXZqcQ9606	rogid:0PnzH1KPp4SKRWfRGotPA2eSHZk9606	intact-crc:9D17A969CB78E3D3|rigid:PQiuaLZRohuV1CsQhuEYkNu7UZE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13611	uniprotkb:P10124	intact:EBI-8515977|intact:MINT-4529155|uniprotkb:Q15123|uniprotkb:P20754|uniprotkb:Q9UNW5|uniprotkb:Q13189|uniprotkb:Q13010|uniprotkb:Q9UCL9|ensembl:ENSP00000265077	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:cspg2_human(display_long)|uniprotkb:VCAN(gene name)|psi-mi:VCAN(display_short)|uniprotkb:CSPG2(gene name synonym)|uniprotkb:Large fibroblast proteoglycan(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan core protein 2(gene name synonym)|uniprotkb:PG-M(gene name synonym)|uniprotkb:Glial hyaluronate-binding protein(gene name synonym)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0512"(zymography)	Malla et al. (2013)	mint:fj-13-0162|pubmed:23601700|mint:MINT-8426754	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8516119|mint:MINT-8427443	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119808.1|refseq:NP_001157569.1|refseq:NP_001157570.1|refseq:NP_004376.2|ensembl:ENSG00000038427(gene)|ensembl:ENST00000265077(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007417"(central nervous system development)|go:"GO:0008037"(cell recognition)|go:"GO:0008347"(glial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033165"(interphotoreceptor matrix)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000538(Link)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018097|interpro:IPR018378|interpro:IPR033987|interpro:IPR035976|interpro:IPR036179|mint:P13611|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-381426|reactome:R-HSA-4420332|reactome:R-HSA-8957275|mint:MINT-8427478(identity)	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1|mint:MINT-8427479(identity)	-	comment:mint|comment:homomint|function:May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid|function:"Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1) [MIM:143200]. WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN"	-	comment:homomint|comment:mint|figure legend:f1 f2  f3 f6b f6c f7 f8	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/16	2014/10/16	rogid:hnqTxboVu1BtuxYP2jENLXXZqcQ9606	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	intact-crc:9D17A969CB78E3D3|rigid:PQiuaLZRohuV1CsQhuEYkNu7UZE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13611	uniprotkb:P14780	intact:EBI-8515977|intact:MINT-4529155|uniprotkb:Q15123|uniprotkb:P20754|uniprotkb:Q9UNW5|uniprotkb:Q13189|uniprotkb:Q13010|uniprotkb:Q9UCL9|ensembl:ENSP00000265077	intact:EBI-1382326|uniprotkb:Q3LR70|uniprotkb:Q8N725|uniprotkb:Q9H4Z1|uniprotkb:B2R7V9|uniprotkb:Q9UCJ9|uniprotkb:Q9UCL1|uniprotkb:Q9UDK2|ensembl:ENSP00000361405	psi-mi:cspg2_human(display_long)|uniprotkb:VCAN(gene name)|psi-mi:VCAN(display_short)|uniprotkb:CSPG2(gene name synonym)|uniprotkb:Large fibroblast proteoglycan(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan core protein 2(gene name synonym)|uniprotkb:PG-M(gene name synonym)|uniprotkb:Glial hyaluronate-binding protein(gene name synonym)	psi-mi:mmp9_human(display_long)|uniprotkb:MMP9(gene name)|psi-mi:MMP9(display_short)|uniprotkb:CLG4B(gene name synonym)|uniprotkb:92 kDa type IV collagenase(gene name synonym)|uniprotkb:92 kDa gelatinase(gene name synonym)|uniprotkb:Gelatinase B(gene name synonym)	psi-mi:"MI:0512"(zymography)	Malla et al. (2013)	mint:fj-13-0162|pubmed:23601700|mint:MINT-8426754	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8516144|mint:MINT-8427495	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119808.1|refseq:NP_001157569.1|refseq:NP_001157570.1|refseq:NP_004376.2|ensembl:ENSG00000038427(gene)|ensembl:ENST00000265077(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007417"(central nervous system development)|go:"GO:0008037"(cell recognition)|go:"GO:0008347"(glial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033165"(interphotoreceptor matrix)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000538(Link)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018097|interpro:IPR018378|interpro:IPR033987|interpro:IPR035976|interpro:IPR036179|mint:P13611|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-381426|reactome:R-HSA-4420332|reactome:R-HSA-8957275|mint:MINT-8427499(identity)	refseq:NP_004985.2|dip:DIP-29518N|ensembl:ENSG00000100985(gene)|ensembl:ENST00000372330(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007566"(embryo implantation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000697"(negative regulation of epithelial cell differentiation involved in kidney development)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001258"(negative regulation of cation channel activity)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028688|interpro:IPR033739|go:"GO:1900122"(positive regulation of receptor binding)|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|mint:P14780|rcsb pdb:1GKC|rcsb pdb:1GKD|rcsb pdb:1ITV|rcsb pdb:1L6J|rcsb pdb:1LKG|rcsb pdb:2OVX|rcsb pdb:2OVZ|rcsb pdb:2OW0|rcsb pdb:2OW1|rcsb pdb:2OW2|rcsb pdb:4H1Q|rcsb pdb:4H2E|rcsb pdb:4H3X|rcsb pdb:4H82|rcsb pdb:4HMA|rcsb pdb:4JIJ|rcsb pdb:4JQG|rcsb pdb:4WZV|rcsb pdb:4XCT|rcsb pdb:5CUH|rcsb pdb:5I12|rcsb pdb:5TH6|rcsb pdb:5TH9|rcsb pdb:5UE3|rcsb pdb:5UE4|rcsb pdb:6ESM|reactome:R-HSA-1433557|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-2022090|reactome:R-HSA-3928665|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-9009391|mint:MINT-8427497(identity)	-	comment:mint|comment:homomint|function:May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid|function:"Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1) [MIM:143200]. WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN"	-	comment:homomint|comment:mint|figure legend:f5c f5d	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/16	2014/10/16	rogid:hnqTxboVu1BtuxYP2jENLXXZqcQ9606	rogid:0PnzH1KPp4SKRWfRGotPA2eSHZk9606	intact-crc:1C0FFD48D934C41B|rigid:M1FW83IW5+iGQeIuA+kVqMrDFtA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)