#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P09038	uniprotkb:P11362-14	intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6	intact:EBI-6622185|ensembl:ENSP00000327229	psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:p11362-14(display_long)|uniprotkb:I(isoform synonym)|uniprotkb:H3(isoform synonym)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:HBGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:N-sam(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622180|imex:IM-20536-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N	ensembl:ENSG00000077782(gene)|ensembl:ENST00000326324(transcript)|intact:EBI-1028277(isoform-parent)|uniprotkb:P11362-14(isoform-parent)	-	-	-	figure legend:no figure|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606	rogid:n4qnyR2rVZ7My1sM3u5KpsJAWAE9606	intact-crc:73EC6874C5AF5E46|rigid:VdQNnbJL+CT3MrW8q3Tmi1uyVm0	false	125i radiolabel:?-?	fc-igg tag:c-c|sufficient binding region:22-285	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P11362-14	uniprotkb:P09038	intact:EBI-6622185|ensembl:ENSP00000327229	intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6	psi-mi:p11362-14(display_long)|uniprotkb:I(isoform synonym)|uniprotkb:H3(isoform synonym)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:HBGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:N-sam(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)	psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622208|imex:IM-20536-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000077782(gene)|ensembl:ENST00000326324(transcript)|intact:EBI-1028277(isoform-parent)|uniprotkb:P11362-14(isoform-parent)	refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N	-	-	-	figure legend:no figure-2|comment:"A 10- to 100-fold molar excess of unlabeled FGF2 or anti-FGFR1 Fab (αFGFR1) inhibited 125I-FGF2 binding completely."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.9x10^-6(molar)	2013/04/23	2014/10/16	rogid:n4qnyR2rVZ7My1sM3u5KpsJAWAE9606	rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606	intact-crc:9035F08F3FFD8010	false	sufficient binding region:22-285|fc-igg tag:c-c	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P11362-14	uniprotkb:P09038	intact:EBI-6622185|ensembl:ENSP00000327229	intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6	psi-mi:p11362-14(display_long)|uniprotkb:I(isoform synonym)|uniprotkb:H3(isoform synonym)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:HBGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:N-sam(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)	psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622208|imex:IM-20536-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000077782(gene)|ensembl:ENST00000326324(transcript)|intact:EBI-1028277(isoform-parent)|uniprotkb:P11362-14(isoform-parent)	refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N	-	-	-	figure legend:no figure-2|comment:"A 10- to 100-fold molar excess of unlabeled FGF2 or anti-FGFR1 Fab (αFGFR1) inhibited 125I-FGF2 binding completely."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.9x10^-6(molar)	2013/04/23	2014/10/16	rogid:n4qnyR2rVZ7My1sM3u5KpsJAWAE9606	rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606	intact-crc:9035F08F3FFD8010	false	sufficient binding region:22-285|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73280"	uniprotkb:P11362-14	intact:EBI-6622221	intact:EBI-6622185|ensembl:ENSP00000327229	psi-mi:ssr(display_short)|psi-mi:"CHEBI:73280"(display_long)	psi-mi:p11362-14(display_long)|uniprotkb:I(isoform synonym)|uniprotkb:H3(isoform synonym)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:HBGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:N-sam(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622208|imex:IM-20536-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000077782(gene)|ensembl:ENST00000326324(transcript)|intact:EBI-1028277(isoform-parent)|uniprotkb:P11362-14(isoform-parent)	-	-	-	figure legend:no figure-2|comment:"A 10- to 100-fold molar excess of unlabeled FGF2 or anti-FGFR1 Fab (αFGFR1) inhibited 125I-FGF2 binding completely."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.9x10^-6(molar)	2013/04/23	2014/10/16	-	rogid:n4qnyR2rVZ7My1sM3u5KpsJAWAE9606	intact-crc:9035F08F3FFD8010	false	-	sufficient binding region:22-285|fc-igg tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73472"	uniprotkb:P21397	intact:EBI-6662560	intact:EBI-1190845|uniprotkb:Q16426|uniprotkb:B4DF46|ensembl:ENSP00000340684	psi-mi:kynuramine(display_short)|psi-mi:"CHEBI:73472"(display_long)	psi-mi:aofa_human(display_long)|uniprotkb:MAOA(gene name)|psi-mi:MAOA(display_short)|uniprotkb:Monoamine oxidase type A(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662564|imex:IM-20536-138	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000231.1|refseq:NP_001257387.1|ensembl:ENSG00000189221(gene)|ensembl:ENST00000338702(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042135"(neurotransmitter catabolic process)|go:"GO:0042420"(dopamine catabolic process)|go:"GO:0097621"(monoamine oxidase activity)|interpro:IPR001613(Flavin-containing amine oxidase)|interpro:IPR002937(Amine oxidase)|interpro:IPR036188|mint:P21397|rcsb pdb:1H8Q|rcsb pdb:2BXR|rcsb pdb:2BXS|rcsb pdb:2Z5X|rcsb pdb:2Z5Y|reactome:R-HSA-141333|reactome:R-HSA-181430|reactome:R-HSA-379397|reactome:R-HSA-379398|reactome:R-HSA-380612|reactome:R-HSA-5579012|reactome:R-HSA-6785807	-	-	-	figure legend:Table S2-135|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:I1KqinKud3ZwsSxYy04XYSoqaF09606	intact-crc:9B3582F18D8548E9	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73340"	uniprotkb:P08912	intact:EBI-6655199	intact:EBI-6655256|ensembl:ENSP00000372750|ensembl:ENSP00000453745|uniprotkb:Q96RG7	psi-mi:4-damp(display_short)|psi-mi:"CHEBI:73340"(display_long)	psi-mi:acm5_human(display_long)|uniprotkb:CHRM5(gene name)|psi-mi:CHRM5(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655279|imex:IM-20536-94	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0060304"(regulation of phosphatidylinositol dephosphorylation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000502(Muscarinic acetylcholine receptor M5)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6OL9|reactome:R-HSA-390648|reactome:R-HSA-416476|ensembl:ENSG00000184984(gene)|ensembl:ENST00000383263(transcript)|ensembl:ENST00000557872(transcript)|go:"GO:0001696"(gastric acid secretion)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0015872"(dopamine transport)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0030425"(dendrite)|refseq:NP_036257.1|refseq:NP_001307846.1	-	-	-	figure legend:Table S2-70|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:hPgsxAdXxOpCz4n+SU87Kje0gVQ9606	intact-crc:78390A6D5C47A122	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25929	uniprotkb:P10082	intact:EBI-372227|uniprotkb:B2R6H5|ensembl:ENSP00000354652	intact:EBI-6655667|ensembl:ENSP00000353198|uniprotkb:Q5U5Q6|uniprotkb:Q6FGH8	psi-mi:npy1r_human(display_long)|uniprotkb:NPY1R(gene name)|psi-mi:NPY1R(display_short)|uniprotkb:NPYR(gene name synonym)|uniprotkb:NPYY1(gene name synonym)	psi-mi:pyy_human(display_long)|uniprotkb:PYY(gene name)|psi-mi:PYY(display_short)|uniprotkb:PYY-I(gene name synonym)|uniprotkb:Peptide tyrosine tyrosine(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655703|imex:IM-20536-40	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530312.1|refseq:NP_000900.1|refseq:XP_005263088.1|ensembl:ENSG00000164128(gene)|ensembl:ENST00000296533(transcript)|go:"GO:0001602"(pancreatic polypeptide receptor activity)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004983"(neuropeptide Y receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000351(Neuropeptide Y1 receptor)|interpro:IPR000611(Neuropeptide Y receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2F1U|rcsb pdb:2IIL|rcsb pdb:5ZBQ|reactome:R-HSA-375276|reactome:R-HSA-418594	refseq:XP_011523337.1|ensembl:ENST00000360085(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007631"(feeding behavior)|go:"GO:0031841"(neuropeptide Y receptor binding)|go:"GO:0060575"(intestinal epithelial cell differentiation)|interpro:IPR001955(Pancreatic hormone)|interpro:IPR020392|rcsb pdb:2DEZ|rcsb pdb:2DF0|rcsb pdb:2L60|rcsb pdb:2NA5|reactome:R-HSA-375276|reactome:R-HSA-418594|ensembl:ENSG00000131096(gene)|refseq:NP_004151.3	-	-	-	figure legend:Table S2-78|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:Znnr1wafoTgjDhpe9OWZ1aBOa/s9606	rogid:VKGXqAYXru2Kad45HYBcvqSIEyY9606	intact-crc:6B6B3316D7DBC01D|rigid:eTNwFVKAxbx460JIUiWuXm2yvyY	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73380"	uniprotkb:Q13639	intact:EBI-6656483	intact:EBI-6656425|ensembl:ENSP00000367120|ensembl:ENSP00000485747|uniprotkb:Q546Q1|uniprotkb:Q684M0|uniprotkb:Q712M9|uniprotkb:Q96KH9|uniprotkb:Q96KI0|uniprotkb:Q9H199|uniprotkb:Q9NY73|uniprotkb:Q9UBM6|uniprotkb:Q9UBT4|uniprotkb:Q9UE22|uniprotkb:Q9UE23|uniprotkb:Q9UQR6|uniprotkb:C4WYH4	psi-mi:gr 113808(display_short)|psi-mi:"CHEBI:73380"(display_long)	psi-mi:5ht4r_human(display_long)|uniprotkb:HTR4(gene name)|psi-mi:HTR4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656491|imex:IM-20536-108	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001273339.1|ensembl:ENSG00000164270(gene)|ensembl:ENST00000377888(transcript)|ensembl:ENST00000631296(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q13639|rcsb pdb:5EM9|reactome:R-HSA-390666|reactome:R-HSA-418555|reactome:R-HSA-9660821|refseq:NP_000861.1|refseq:NP_001035259.1|refseq:NP_001035262.2|refseq:NP_001035263.1|refseq:NP_955525.1	-	-	-	figure legend:Table S2-100|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:5+1AMJ2Bq46D7PZcb+0pVHgBY/U9606	intact-crc:EFA7ABE9C5C1452F	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P32241	uniprotkb:P01282-PRO_0000011460	intact:EBI-3917984|uniprotkb:A5JUT9|uniprotkb:Q15871|uniprotkb:Q6P2M6|uniprotkb:B3KPV1|uniprotkb:B4DGI4|uniprotkb:F5H1F5|uniprotkb:G3V0I1|uniprotkb:B4DEB5|ensembl:ENSP00000327246	intact:EBI-6656819	psi-mi:vipr1_human(display_long)|uniprotkb:VIPR1(gene name)|psi-mi:VIPR1(display_short)|uniprotkb:Pituitary adenylate cyclase-activating polypeptide type II receptor(gene name synonym)|uniprotkb:VPAC1(gene name synonym)	psi-mi:p01282-pro_0000011460(display_long)|uniprotkb:VIP(gene name)|psi-mi:VIP(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656826|imex:IM-20536-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004615.2|refseq:NP_001238812.1|refseq:NP_001238811.1|refseq:NP_001238813.1|refseq:NP_001238814.1|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001571(GPCR, family 2, vasoactive intestinal peptide receptor)|interpro:IPR001771(GPCR, family 2, vasoactive intestinal peptide receptor 1)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3DTX|rcsb pdb:3HCV|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:6VN7|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|go:"GO:0043235"(receptor complex)|ensembl:ENSG00000114812(gene)|ensembl:ENST00000325123(transcript)|go:"GO:0004999"(vasoactive intestinal polypeptide receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0017046"(peptide hormone binding)|refseq:XP_005265495.1|refseq:XP_011532381.1	intact:EBI-751454(chain-parent)	-	-	chain-seq-start:125|chain-seq-end:152	figure legend:Table S2-115|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:DBdFfrPCE6B+JrkT9HLBrn09l0k9606	rogid:Ig8+sQ7x2wnattJ+N1G6SY+8xYA9606	intact-crc:572E26B9E1072EDF|rigid:JpvVSVw2eW03a9JeMT5dMjYJ6po	false	-	3h radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q13519-PRO_0000008327	uniprotkb:P41146	intact:EBI-6656256	intact:EBI-2624699|uniprotkb:Q8TD34|uniprotkb:Q8WYH9|uniprotkb:Q9H4K4|ensembl:ENSP00000336764|ensembl:ENSP00000336843|ensembl:ENSP00000347848	psi-mi:q13519-pro_0000008327(display_long)|uniprotkb:PNOC(gene name)|psi-mi:PNOC(display_short)|uniprotkb:OFQ(gene name synonym)	psi-mi:oprx_human(display_long)|uniprotkb:OPRL1(gene name)|psi-mi:OPRL1(display_short)|uniprotkb:OOR(gene name synonym)|uniprotkb:ORL1(gene name synonym)|uniprotkb:Orphanin FQ receptor(gene name synonym)|uniprotkb:Kappa-type 3 opioid receptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656273|imex:IM-20536-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6656238(chain-parent)	refseq:NP_000904.1|refseq:NP_001186948.1|refseq:NP_872588.1|refseq:XP_016883343.1|refseq:XP_016883344.1|ensembl:ENSG00000125510(gene)|ensembl:ENST00000336866(transcript)|ensembl:ENST00000349451(transcript)|ensembl:ENST00000355631(transcript)|go:"GO:0001626"(nociceptin receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007600"(sensory perception)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060454"(positive regulation of gastric acid secretion)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:1990708"(conditioned place preference)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR001420(X opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P41146|rcsb pdb:4EA3|rcsb pdb:5DHG|rcsb pdb:5DHH|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_001305782.1|refseq:NP_001305783.1|refseq:NP_001305784.1	-	chain-seq-start:130|chain-seq-end:146	-	figure legend:Table S2-90|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:QkWdfrsF2pxBB2+A69ZLyL7fgJA9606	rogid:XB+gV8yHArDnVcaYZADiPZRgncE9606	intact-crc:A81056202E8A455F|rigid:IDIaYPEPApM3YRAdrjuzxZ3Wou0	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73286"	uniprotkb:P33765	intact:EBI-6622661	intact:EBI-6622619|uniprotkb:A2A3P4|uniprotkb:Q6UWU0|uniprotkb:Q9BYZ1|uniprotkb:P0DMS8	psi-mi:ib-meca(display_short)|psi-mi:"CHEBI:73286"(display_long)	psi-mi:aa3r_human(display_long)|uniprotkb:ADORA3(gene name)|psi-mi:ADORA3(display_short)|uniprotkb:UNQ1931/PRO4406(orf name)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622655|imex:IM-20536-61	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0042629"(mast cell granule)|interpro:IPR000466(Adenosine A3 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0006954"(inflammatory response)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0007165"(signal transduction)|refseq:NP_000668.1|refseq:NP_065734.5|rcsb pdb:1OEA|rcsb pdb:1R7N|reactome:REACT_18288|reactome:REACT_19231|ensembl:ENSG00000121933|ensembl:ENSP00000241356|ensembl:ENSP00000358730|go:"GO:0005886"(plasma membrane)|go:"GO:0009611"(response to wounding)|ensembl:ENST00000241356|ensembl:ENST00000369716|ensembl:ENSG00000282608|reactome:R-HSA-417973|reactome:R-HSA-418594|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)	-	-	-	figure legend:Table S2-6|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.5x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:HnLwBgguLQ+9gQg1ReMPZbD/E0U9606	intact-crc:6A770DD134996835	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73285"	uniprotkb:P33765	intact:EBI-6622653	intact:EBI-6622619|uniprotkb:A2A3P4|uniprotkb:Q6UWU0|uniprotkb:Q9BYZ1|uniprotkb:P0DMS8	psi-mi:ab-meca(display_short)|psi-mi:"CHEBI:73285"(display_long)	psi-mi:aa3r_human(display_long)|uniprotkb:ADORA3(gene name)|psi-mi:ADORA3(display_short)|uniprotkb:UNQ1931/PRO4406(orf name)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622655|imex:IM-20536-61	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0042629"(mast cell granule)|interpro:IPR000466(Adenosine A3 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0006954"(inflammatory response)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0007165"(signal transduction)|refseq:NP_000668.1|refseq:NP_065734.5|rcsb pdb:1OEA|rcsb pdb:1R7N|reactome:REACT_18288|reactome:REACT_19231|ensembl:ENSG00000121933|ensembl:ENSP00000241356|ensembl:ENSP00000358730|go:"GO:0005886"(plasma membrane)|go:"GO:0009611"(response to wounding)|ensembl:ENST00000241356|ensembl:ENST00000369716|ensembl:ENSG00000282608|reactome:R-HSA-417973|reactome:R-HSA-418594|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)	-	-	-	figure legend:Table S2-6|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.5x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:HnLwBgguLQ+9gQg1ReMPZbD/E0U9606	intact-crc:6A770DD134996835	false	125i radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P13236-PRO_0000005165	uniprotkb:P51681	intact:EBI-6625160	intact:EBI-489374|uniprotkb:O14692|uniprotkb:O14693|uniprotkb:O14695|uniprotkb:O14696|uniprotkb:O14697|uniprotkb:O14698|uniprotkb:O14699|uniprotkb:O14700|uniprotkb:O14701|uniprotkb:O14702|uniprotkb:O14703|uniprotkb:O14704|uniprotkb:O14705|uniprotkb:O14706|uniprotkb:O14707|uniprotkb:O14708|uniprotkb:O15538|uniprotkb:Q9UPA4|ensembl:ENSP00000292303|ensembl:ENSP00000404881	psi-mi:p13236-pro_0000005165(display_long)|uniprotkb:CCL4(gene name)|psi-mi:CCL4(display_short)|uniprotkb:LAG1(gene name synonym)|uniprotkb:MIP1B(gene name synonym)|uniprotkb:SCYA4(gene name synonym)|uniprotkb:G-26 T-lymphocyte-secreted protein(gene name synonym)|uniprotkb:HC21(gene name synonym)|uniprotkb:Lymphocyte activation gene 1 protein(gene name synonym)|uniprotkb:"MIP-1-beta(1-69)"(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-beta(gene name synonym)|uniprotkb:PAT 744(gene name synonym)|uniprotkb:Protein H400(gene name synonym)|uniprotkb:SIS-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine A4(gene name synonym)|uniprotkb:T-cell activation protein 2(gene name synonym)	psi-mi:ccr5_human(display_long)|uniprotkb:HIV-1 fusion coreceptor(gene name synonym)|uniprotkb:CHEMR13(gene name synonym)|uniprotkb:CCR5(gene name)|psi-mi:CCR5(display_short)|uniprotkb:CMKBR5(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6625188|imex:IM-20536-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2873970(chain-parent)	go:"GO:0019722"(calcium-mediated signaling)|refseq:NP_000570.1|refseq:NP_001093638.1|ensembl:ENSG00000160791(gene)|ensembl:ENST00000292303(transcript)|ensembl:ENST00000445772(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016493"(C-C chemokine receptor activity)|rcsb pdb:4MBS|rcsb pdb:5UIW|rcsb pdb:5YD3|rcsb pdb:5YD4|rcsb pdb:5YD5|rcsb pdb:5YY4|rcsb pdb:6FGP|rcsb pdb:6MEO|rcsb pdb:6MET|rcsb pdb:7O7F|reactome:R-HSA-173107|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:2RRS|go:"GO:0023052"(signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002240(C-C chemokine receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P51681|rcsb pdb:1ND8|rcsb pdb:1NE0|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:2L87|go:"GO:0019957"(C-C chemokine binding)|rcsb pdb:2MZX|rcsb pdb:2RLL|dip:DIP-5866N	-	chain-seq-start:26|chain-seq-end:92	-	figure legend:Table S2-54|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:Xy0Ic9Q5Kh9dTxlbD48VPGDPKDY9606	rogid:qpXGapPDi9co6c1kf2NgfM1qkA89606	intact-crc:6B3F9A1FCE5A84B7|rigid:L2g4/kDCtU73smGpUVpWMDtaUZc	false	125i radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73337"	uniprotkb:Q9Y5N1	intact:EBI-6655140	intact:EBI-6626124|ensembl:ENSP00000342560|uniprotkb:Q4QRI7|uniprotkb:Q9GZX2|uniprotkb:Q9H4K8	psi-mi:"(r)α-me-histamine"(display_short)|psi-mi:"CHEBI:73337"(display_long)	psi-mi:hrh3_human(display_long)|uniprotkb:HRH3(gene name)|psi-mi:HRH3(display_short)|uniprotkb:GPCR97(gene name synonym)|uniprotkb:G-protein coupled receptor 97(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655143|imex:IM-20536-85	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0045202"(synapse)|go:"GO:0050890"(cognition)|go:"GO:0098793"(presynapse)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003980(Histamine H3 receptor)|ensembl:ENSG00000101180(gene)|ensembl:ENST00000340177(transcript)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390650|go:"GO:0004969"(histamine receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|refseq:NP_009163.2|refseq:XP_005260323.1|dip:DIP-61456N	-	-	-	figure legend:Table S2-60|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:SXyMPoRgJlcfEl9djDo6Qw2yctE9606	intact-crc:C191D5444F0CF613	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73282"	uniprotkb:P30542	intact:EBI-6622582	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	psi-mi:dpcpx(display_short)|psi-mi:"CHEBI:73282"(display_long)	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622579|imex:IM-20536-56	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	-	-	-	figure legend:Table S2-1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	intact-crc:BF52B19463DADA90	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:6762"	uniprotkb:P35367	intact:EBI-6625195	intact:EBI-6595281|ensembl:ENSP00000380247|ensembl:ENSP00000397028|ensembl:ENSP00000406705|uniprotkb:Q6P9E5|uniprotkb:A8K047	psi-mi:pyrilamine(display_short)|psi-mi:"CHEBI:6762"(display_long)	psi-mi:hrh1_human(display_long)|uniprotkb:HRH1(gene name)|psi-mi:HRH1(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6625205|imex:IM-20536-82	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000196639(gene)|ensembl:ENST00000397056(transcript)|ensembl:ENST00000431010(transcript)|ensembl:ENST00000438284(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004969"(histamine receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007613"(memory)|go:"GO:0008542"(visual learning)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048016"(inositol phosphate-mediated signaling)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0071420"(cellular response to histamine)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000921(Histamine H1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:3RZE|rcsb pdb:7DFL|reactome:R-HSA-390650|reactome:R-HSA-416476|go:"GO:0032962"(positive regulation of inositol trisphosphate biosynthetic process)|refseq:XP_011531954.1|refseq:XP_011531955.1|refseq:NP_000852.1|refseq:NP_001091681.1|refseq:NP_001091682.1|refseq:NP_001091683.1|refseq:XP_016861772.1|refseq:XP_016861773.1|dip:DIP-41996N	-	-	-	figure legend:Table S2-56|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:M/dOvMtHvMlNwA26qSdb5hqV1xQ9606	intact-crc:C4E83CC40652582F	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73370"	uniprotkb:P28222	intact:EBI-6656310	intact:EBI-1056863|uniprotkb:Q4VAY7|ensembl:ENSP00000358963	psi-mi:iodocyanopindolol/cyp(display_short)|psi-mi:"CHEBI:73370"(display_long)	psi-mi:5ht1b_human(display_long)|uniprotkb:HTR1B(gene name)|psi-mi:HTR1B(display_short)|uniprotkb:HTR1DB(gene name synonym)|uniprotkb:Serotonin receptor 1B(gene name synonym)|uniprotkb:Serotonin 1D beta receptor(gene name synonym)|uniprotkb:S12(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656315|imex:IM-20536-102	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000854.1|ensembl:ENSG00000135312(gene)|ensembl:ENST00000369947(transcript)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014053"(negative regulation of gamma-aminobutyric acid secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0030425"(dendrite)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0035690"|go:"GO:0042220"(response to cocaine)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042756"(drinking behavior)|go:"GO:0044305"(calyx of Held)|go:"GO:0045471"(response to ethanol)|go:"GO:0046849"(bone remodeling)|go:"GO:0050795"(regulation of behavior)|go:"GO:0051378"(serotonin binding)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071502"(cellular response to temperature stimulus)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099154"(serotonergic synapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002147(5-Hydroxytryptamine 1B receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2G1X|rcsb pdb:4IAQ|rcsb pdb:4IAR|rcsb pdb:5V54|rcsb pdb:6G79|rcsb pdb:7C61|reactome:R-HSA-390666|reactome:R-HSA-418594|go:"GO:0030594"(neurotransmitter receptor activity)	-	-	-	figure legend:Table S2-94|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:KFPTq2aY7OgpBIAdtvUbOX5mnv49606	intact-crc:DD4C5964B1D2700A	false	125i radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P01210-PRO_0000008243	uniprotkb:P35372	intact:EBI-6656055	intact:EBI-2624570|uniprotkb:B0FXJ1|uniprotkb:B8Q1L8|uniprotkb:B8Q1L9|uniprotkb:Q6UPP1|uniprotkb:Q86V80|uniprotkb:G8XRH8|uniprotkb:B2R9S7|uniprotkb:B8Q1L7|uniprotkb:Q12930|uniprotkb:Q4VWM1|uniprotkb:Q4VWM2|uniprotkb:Q4VWM3|uniprotkb:Q4VWM4|uniprotkb:Q4VWM6|uniprotkb:Q4VWX6|uniprotkb:Q5TDA1|uniprotkb:Q6UQ80|uniprotkb:Q7Z2D8|uniprotkb:Q8IWW3|uniprotkb:Q8IWW4|uniprotkb:Q9UCZ4|uniprotkb:Q9UN57|uniprotkb:G8XRH6|ensembl:ENSP00000328264|uniprotkb:E7EWZ3	psi-mi:p01210-pro_0000008243(display_long)|uniprotkb:PENK(gene name)|psi-mi:PENK(display_short)	psi-mi:oprm_human(display_long)|uniprotkb:OPRM1(gene name)|psi-mi:OPRM1(display_short)|uniprotkb:MOR1(gene name synonym)|uniprotkb:Mu opioid receptor(gene name synonym)|uniprotkb:Mu opiate receptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656114|imex:IM-20536-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6656032(chain-parent)	refseq:NP_001272453.1|refseq:NP_001272455.1|refseq:NP_001272456.1|refseq:NP_001272457.1|refseq:NP_001138752.1|refseq:NP_001138753.1|refseq:NP_001272452.1|refseq:NP_000905.3|refseq:NP_001008503.2|refseq:NP_001008504.2|refseq:NP_001008505.2|refseq:NP_001138751.1|refseq:NP_001138754.1|refseq:NP_001138755.1|refseq:NP_001138756.1|refseq:NP_001138757.1|refseq:NP_001138758.1|refseq:NP_001138759.1|refseq:XP_016866395.1|ensembl:ENSG00000112038(gene)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007600"(sensory perception)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031005"(filamin binding)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032094"(response to food)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|ensembl:ENST00000330432(transcript)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038047"(morphine receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004979"(beta-endorphin receptor activity)|go:"GO:0042755"(eating behavior)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0005768"(endosome)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061358"(negative regulation of Wnt protein secretion)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097444"(spine apparatus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000105(Mu opioid receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35372|reactome:R-HSA-111885|reactome:R-HSA-202040|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|reactome:R-HSA-418594|reactome:R-HSA-6785807|reactome:R-HSA-9022699|reactome:R-HSA-375276	-	chain-seq-start:100|chain-seq-end:104	-	figure legend:Table S2-88|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:bz5sbFu/WDiWtYrAxeiR26fZRwg9606	rogid:pfkhVhvpn9gSXiBRs1OBXJBCI3s9606	intact-crc:9DAE9CC8B0F6E478|rigid:wVZWiVbWvBXfkEQ/6w3LnOlJtvc	false	mutation:5-5|N-methyl-L-phenylalanine:4-4|3h radiolabel:?-?|mutation:2-2	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P06881	uniprotkb:Q16602	intact:EBI-962928|ensembl:ENSP00000354286|ensembl:ENSP00000417833|uniprotkb:Q93048|uniprotkb:Q9UCP0	intact:EBI-962878|ensembl:ENSP00000376177|ensembl:ENSP00000386972|ensembl:ENSP00000387190|uniprotkb:A8KAD3|uniprotkb:A8K6G5|uniprotkb:Q53S02|uniprotkb:Q53TS5	psi-mi:calca_human(display_long)|uniprotkb:CALCA(gene name)|psi-mi:CALCA(display_short)|uniprotkb:CALC1(gene name synonym)|uniprotkb:Calcitonin gene-related peptide I(gene name synonym)|uniprotkb:Alpha-type CGRP(gene name synonym)	psi-mi:calrl_human(display_long)|uniprotkb:CALCRL(gene name)|psi-mi:CALCRL(display_short)|uniprotkb:CGRPR(gene name synonym)|uniprotkb:Calcitonin receptor-like receptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623429|imex:IM-20536-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000361010(transcript)|ensembl:ENST00000486207(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001944"(vasculature development)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|ensembl:ENSG00000110680(gene)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0031623"(receptor internalization)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0042311"(vasodilation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|interpro:IPR001693(Calcitonin-like)|interpro:IPR015476(Calcitonin gene related peptide)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1LS7|rcsb pdb:6E3Y|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|refseq:NP_001029125.1	interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003287(GPCR, family 2, calcitonin receptor-like)|interpro:IPR003289(GPCR, family 2, calcitonin gene-related peptide, type 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:3AQF|rcsb pdb:3N7P|rcsb pdb:3N7R|rcsb pdb:3N7S|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:5V6Y|rcsb pdb:6D1U|rcsb pdb:6E3Y|rcsb pdb:6UMG|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6V2E|rcsb pdb:6ZHO|rcsb pdb:6ZIS|rcsb pdb:7KNT|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|ensembl:ENSG00000064989(gene)|ensembl:ENST00000392370(transcript)|ensembl:ENST00000409998(transcript)|ensembl:ENST00000410068(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004948"(calcitonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071329"(cellular response to sucrose stimulus)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:0005886"(plasma membrane)|refseq:NP_005786.1|refseq:NP_001258680.1|dip:DIP-37674N	-	-	-	figure legend:Table S2-23|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2018/09/18	rogid:gM1XX8NUOJKraSnqNoX6NO0oH8E9606	rogid:CezdatTOyGz/AEKWvRS/lTOrl9A9606	intact-crc:69A80440425A7637|rigid:kjISyunlOARToAqMHuNth3kY+Ls	false	125i radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73356"	uniprotkb:P41143	intact:EBI-6655858	intact:EBI-2624456|uniprotkb:B5B0B8|ensembl:ENSP00000234961	psi-mi:dpdpe(display_short)|psi-mi:"CHEBI:73356"(display_long)	psi-mi:oprd_human(display_long)|uniprotkb:OPRD1(gene name)|psi-mi:OPRD1(display_short)|uniprotkb:OPRD(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655915|imex:IM-20536-97	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000902.3|ensembl:ENSG00000116329(gene)|ensembl:ENST00000234961(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032590"(dendrite membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038046"(G protein-coupled enkephalin receptor activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043679"(axon terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097444"(spine apparatus)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000321(Delta opioid receptor)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P41143|rcsb pdb:1OZC|rcsb pdb:2IQM|rcsb pdb:4N6H|rcsb pdb:4RWA|rcsb pdb:4RWD|rcsb pdb:6PT2|rcsb pdb:6PT3|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-6785807|go:"GO:0071456"(cellular response to hypoxia)	-	-	-	figure legend:Table S2-84|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:47Egb9vEVBuRADGdyZqCRPHk5gI9606	intact-crc:D79ABF3FB81E72AE	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73364"	uniprotkb:P08908	intact:EBI-6656292	intact:EBI-6570214|ensembl:ENSP00000316244|uniprotkb:Q6LAE7	psi-mi:8-oh-dpat(display_short)|psi-mi:"CHEBI:73364"(display_long)	psi-mi:5ht1a_human(display_long)|uniprotkb:HTR1A(gene name)|psi-mi:HTR1A(display_short)|uniprotkb:ADRB2RL1(gene name synonym)|uniprotkb:ADRBRL1(gene name synonym)|uniprotkb:G-21(gene name synonym)|uniprotkb:Serotonin receptor 1A(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656284|imex:IM-20536-99	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000178394(gene)|ensembl:ENST00000323865(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014062"(regulation of serotonin secretion)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0035640"(exploration behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0045202"(synapse)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0050795"(regulation of behavior)|go:"GO:0051378"(serotonin binding)|go:"GO:0090722"(receptor-receptor interaction)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000610(5-Hydroxytryptamine 1A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|reactome:R-HSA-390666|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|refseq:NP_000515.2	-	-	-	figure legend:Table S2-91|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.56x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:EAQbnziwFuwqt4cDvISKLpVNQK49606	intact-crc:FED40EACDC50FD52	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73364"	uniprotkb:P08908	intact:EBI-6656292	intact:EBI-6570214|ensembl:ENSP00000316244|uniprotkb:Q6LAE7	psi-mi:8-oh-dpat(display_short)|psi-mi:"CHEBI:73364"(display_long)	psi-mi:5ht1a_human(display_long)|uniprotkb:HTR1A(gene name)|psi-mi:HTR1A(display_short)|uniprotkb:ADRB2RL1(gene name synonym)|uniprotkb:ADRBRL1(gene name synonym)|uniprotkb:G-21(gene name synonym)|uniprotkb:Serotonin receptor 1A(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656284|imex:IM-20536-99	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000178394(gene)|ensembl:ENST00000323865(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014062"(regulation of serotonin secretion)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0035640"(exploration behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0045202"(synapse)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0050795"(regulation of behavior)|go:"GO:0051378"(serotonin binding)|go:"GO:0090722"(receptor-receptor interaction)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000610(5-Hydroxytryptamine 1A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|reactome:R-HSA-390666|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|refseq:NP_000515.2	-	-	-	figure legend:Table S2-91|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.56x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:EAQbnziwFuwqt4cDvISKLpVNQK49606	intact-crc:FED40EACDC50FD52	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25929	uniprotkb:P01303-PRO_0000025321	intact:EBI-372227|uniprotkb:B2R6H5|ensembl:ENSP00000354652	intact:EBI-6655696	psi-mi:npy1r_human(display_long)|uniprotkb:NPY1R(gene name)|psi-mi:NPY1R(display_short)|uniprotkb:NPYR(gene name synonym)|uniprotkb:NPYY1(gene name synonym)	psi-mi:p01303-pro_0000025321(display_long)|uniprotkb:NPY(gene name)|psi-mi:NPY(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655641|imex:IM-20536-38	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530312.1|refseq:NP_000900.1|refseq:XP_005263088.1|ensembl:ENSG00000164128(gene)|ensembl:ENST00000296533(transcript)|go:"GO:0001602"(pancreatic polypeptide receptor activity)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004983"(neuropeptide Y receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000351(Neuropeptide Y1 receptor)|interpro:IPR000611(Neuropeptide Y receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2F1U|rcsb pdb:2IIL|rcsb pdb:5ZBQ|reactome:R-HSA-375276|reactome:R-HSA-418594	intact:EBI-3905877(chain-parent)	-	-	chain-seq-start:29|chain-seq-end:64	figure legend:Table S2-77|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.72x10^-9(molar)	2013/04/23	2014/10/16	rogid:Znnr1wafoTgjDhpe9OWZ1aBOa/s9606	rogid:l77uVimxXMyF2yZTXkgD2mA0rGY9606	intact-crc:05CE0A3C7EE3997A|rigid:ZEeE+5qbrcSlE0/GbmeJhn4F8/o	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25929	uniprotkb:P10082	intact:EBI-372227|uniprotkb:B2R6H5|ensembl:ENSP00000354652	intact:EBI-6655667|ensembl:ENSP00000353198|uniprotkb:Q5U5Q6|uniprotkb:Q6FGH8	psi-mi:npy1r_human(display_long)|uniprotkb:NPY1R(gene name)|psi-mi:NPY1R(display_short)|uniprotkb:NPYR(gene name synonym)|uniprotkb:NPYY1(gene name synonym)	psi-mi:pyy_human(display_long)|uniprotkb:PYY(gene name)|psi-mi:PYY(display_short)|uniprotkb:PYY-I(gene name synonym)|uniprotkb:Peptide tyrosine tyrosine(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655641|imex:IM-20536-38	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530312.1|refseq:NP_000900.1|refseq:XP_005263088.1|ensembl:ENSG00000164128(gene)|ensembl:ENST00000296533(transcript)|go:"GO:0001602"(pancreatic polypeptide receptor activity)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004983"(neuropeptide Y receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000351(Neuropeptide Y1 receptor)|interpro:IPR000611(Neuropeptide Y receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2F1U|rcsb pdb:2IIL|rcsb pdb:5ZBQ|reactome:R-HSA-375276|reactome:R-HSA-418594	refseq:XP_011523337.1|ensembl:ENST00000360085(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007631"(feeding behavior)|go:"GO:0031841"(neuropeptide Y receptor binding)|go:"GO:0060575"(intestinal epithelial cell differentiation)|interpro:IPR001955(Pancreatic hormone)|interpro:IPR020392|rcsb pdb:2DEZ|rcsb pdb:2DF0|rcsb pdb:2L60|rcsb pdb:2NA5|reactome:R-HSA-375276|reactome:R-HSA-418594|ensembl:ENSG00000131096(gene)|refseq:NP_004151.3	-	-	-	figure legend:Table S2-77|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.72x10^-9(molar)	2013/04/23	2014/10/16	rogid:Znnr1wafoTgjDhpe9OWZ1aBOa/s9606	rogid:VKGXqAYXru2Kad45HYBcvqSIEyY9606	intact-crc:05CE0A3C7EE3997A|rigid:ZEeE+5qbrcSlE0/GbmeJhn4F8/o	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P49146	uniprotkb:P01303-PRO_0000025321	intact:EBI-6655721|ensembl:ENSP00000332591|ensembl:ENSP00000426366|uniprotkb:Q13281|uniprotkb:Q13457|uniprotkb:Q4W5G7|uniprotkb:Q6AZZ6|uniprotkb:Q9UE67	intact:EBI-6655696	psi-mi:npy2r_human(display_long)|uniprotkb:NPY2R(gene name)|psi-mi:NPY2R(display_short)|uniprotkb:NPY-Y2 receptor(gene name synonym)	psi-mi:p01303-pro_0000025321(display_long)|uniprotkb:NPY(gene name)|psi-mi:NPY(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655749|imex:IM-20536-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185149(gene)|ensembl:ENST00000329476(transcript)|ensembl:ENST00000506608(transcript)|go:"GO:0001601"(peptide YY receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004983"(neuropeptide Y receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0031645"(negative regulation of nervous system process)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097730"(non-motile cilium)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000611(Neuropeptide Y receptor)|interpro:IPR001358(Neuropeptide Y2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2IK3|reactome:R-HSA-375276|reactome:R-HSA-418594|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046010"(positive regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0046903"(secretion)|go:"GO:0051048"(negative regulation of secretion)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|refseq:NP_000901.1|refseq:XP_005263090.1|refseq:XP_005263091.1	intact:EBI-3905877(chain-parent)	-	-	chain-seq-start:29|chain-seq-end:64	figure legend:Table S2-79b|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.27x10^-9(molar)	2013/04/23	2014/10/16	rogid:wplTy6jjEmXCuJwHL5UZR0mcQQY9606	rogid:l77uVimxXMyF2yZTXkgD2mA0rGY9606	intact-crc:EC0BFCF5F9F3F216|rigid:VGhBZ5NiST3POLGDCDWf4fhNG8A	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P49146	uniprotkb:P10082	intact:EBI-6655721|ensembl:ENSP00000332591|ensembl:ENSP00000426366|uniprotkb:Q13281|uniprotkb:Q13457|uniprotkb:Q4W5G7|uniprotkb:Q6AZZ6|uniprotkb:Q9UE67	intact:EBI-6655667|ensembl:ENSP00000353198|uniprotkb:Q5U5Q6|uniprotkb:Q6FGH8	psi-mi:npy2r_human(display_long)|uniprotkb:NPY2R(gene name)|psi-mi:NPY2R(display_short)|uniprotkb:NPY-Y2 receptor(gene name synonym)	psi-mi:pyy_human(display_long)|uniprotkb:PYY(gene name)|psi-mi:PYY(display_short)|uniprotkb:PYY-I(gene name synonym)|uniprotkb:Peptide tyrosine tyrosine(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655749|imex:IM-20536-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185149(gene)|ensembl:ENST00000329476(transcript)|ensembl:ENST00000506608(transcript)|go:"GO:0001601"(peptide YY receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004983"(neuropeptide Y receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0031645"(negative regulation of nervous system process)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097730"(non-motile cilium)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000611(Neuropeptide Y receptor)|interpro:IPR001358(Neuropeptide Y2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2IK3|reactome:R-HSA-375276|reactome:R-HSA-418594|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046010"(positive regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0046903"(secretion)|go:"GO:0051048"(negative regulation of secretion)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|refseq:NP_000901.1|refseq:XP_005263090.1|refseq:XP_005263091.1	refseq:XP_011523337.1|ensembl:ENST00000360085(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007631"(feeding behavior)|go:"GO:0031841"(neuropeptide Y receptor binding)|go:"GO:0060575"(intestinal epithelial cell differentiation)|interpro:IPR001955(Pancreatic hormone)|interpro:IPR020392|rcsb pdb:2DEZ|rcsb pdb:2DF0|rcsb pdb:2L60|rcsb pdb:2NA5|reactome:R-HSA-375276|reactome:R-HSA-418594|ensembl:ENSG00000131096(gene)|refseq:NP_004151.3	-	-	-	figure legend:Table S2-79b|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.27x10^-9(molar)	2013/04/23	2014/10/16	rogid:wplTy6jjEmXCuJwHL5UZR0mcQQY9606	rogid:VKGXqAYXru2Kad45HYBcvqSIEyY9606	intact-crc:EC0BFCF5F9F3F216|rigid:VGhBZ5NiST3POLGDCDWf4fhNG8A	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:6123"	uniprotkb:P28223	intact:EBI-6656382	intact:EBI-6656333|ensembl:ENSP00000437737|uniprotkb:B2RAC5|uniprotkb:B4DZ79|uniprotkb:F5GWE8|uniprotkb:Q5T8C0	psi-mi:ketanserin(display_short)|psi-mi:"CHEBI:6123"(display_long)	psi-mi:5ht2a_human(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656324|imex:IM-20536-103	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030431"(sleep)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044380"(protein localization to cytoskeleton)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070852"(cell body fiber)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000455(5-Hydroxytryptamine 2A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6A93|rcsb pdb:6A94|rcsb pdb:6WGT|rcsb pdb:6WH4|rcsb pdb:6WHA|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051378"(serotonin binding)|refseq:NP_000612.1|refseq:NP_001159419.1|dip:DIP-41844N	-	-	-	figure legend:Table S2-95|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.9x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	intact-crc:38F6D5E3D697BC11	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:6123"	uniprotkb:P28223	intact:EBI-6656382	intact:EBI-6656333|ensembl:ENSP00000437737|uniprotkb:B2RAC5|uniprotkb:B4DZ79|uniprotkb:F5GWE8|uniprotkb:Q5T8C0	psi-mi:ketanserin(display_short)|psi-mi:"CHEBI:6123"(display_long)	psi-mi:5ht2a_human(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656324|imex:IM-20536-103	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030431"(sleep)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044380"(protein localization to cytoskeleton)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070852"(cell body fiber)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000455(5-Hydroxytryptamine 2A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6A93|rcsb pdb:6A94|rcsb pdb:6WGT|rcsb pdb:6WH4|rcsb pdb:6WHA|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051378"(serotonin binding)|refseq:NP_000612.1|refseq:NP_001159419.1|dip:DIP-41844N	-	-	-	figure legend:Table S2-95|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.9x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	intact-crc:38F6D5E3D697BC11	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:6605"	uniprotkb:P34969	intact:EBI-6656639	intact:EBI-2625020|uniprotkb:B5BUP6|uniprotkb:P78336|uniprotkb:P78372|uniprotkb:P78516|uniprotkb:Q5VX01|uniprotkb:Q5VX02|ensembl:ENSP00000337949|uniprotkb:Q5VX03	psi-mi:lsd-lysergic acid  diethylamide(display_short)|psi-mi:"CHEBI:6605"(display_long)	psi-mi:5ht7r_human(display_long)|uniprotkb:HTR7(gene name)|psi-mi:HTR7(display_short)|uniprotkb:5-HT-X(gene name synonym)|uniprotkb:Serotonin receptor 7(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656668|imex:IM-20536-113	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000863.1|refseq:NP_062873.1|refseq:NP_062874.1|ensembl:ENSG00000148680(gene)|ensembl:ENST00000336152(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008015"(blood circulation)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042310"(vasoconstriction)|go:"GO:0045202"(synapse)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001069(5-Hydroxytryptamine 7 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390666|reactome:R-HSA-418555|reactome:R-HSA-9660821|reactome:R-HSA-9706019	-	-	-	figure legend:Table S2-104|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.1x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:NoHrTf52SNxtQ9a9C5SaPy74CNU9606	intact-crc:0180EBCC98656E1C	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28790"	uniprotkb:P34969	intact:EBI-6656313	intact:EBI-2625020|uniprotkb:B5BUP6|uniprotkb:P78336|uniprotkb:P78372|uniprotkb:P78516|uniprotkb:Q5VX01|uniprotkb:Q5VX02|ensembl:ENSP00000337949|uniprotkb:Q5VX03	psi-mi:serotonin(display_short)|psi-mi:"CHEBI:28790"(display_long)	psi-mi:5ht7r_human(display_long)|uniprotkb:HTR7(gene name)|psi-mi:HTR7(display_short)|uniprotkb:5-HT-X(gene name synonym)|uniprotkb:Serotonin receptor 7(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656668|imex:IM-20536-113	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000863.1|refseq:NP_062873.1|refseq:NP_062874.1|ensembl:ENSG00000148680(gene)|ensembl:ENST00000336152(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008015"(blood circulation)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042310"(vasoconstriction)|go:"GO:0045202"(synapse)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001069(5-Hydroxytryptamine 7 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390666|reactome:R-HSA-418555|reactome:R-HSA-9660821|reactome:R-HSA-9706019	-	-	-	figure legend:Table S2-104|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.1x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:NoHrTf52SNxtQ9a9C5SaPy74CNU9606	intact-crc:0180EBCC98656E1C	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P35372	uniprotkb:P01210-PRO_0000008243	intact:EBI-2624570|uniprotkb:B0FXJ1|uniprotkb:B8Q1L8|uniprotkb:B8Q1L9|uniprotkb:Q6UPP1|uniprotkb:Q86V80|uniprotkb:G8XRH8|uniprotkb:B2R9S7|uniprotkb:B8Q1L7|uniprotkb:Q12930|uniprotkb:Q4VWM1|uniprotkb:Q4VWM2|uniprotkb:Q4VWM3|uniprotkb:Q4VWM4|uniprotkb:Q4VWM6|uniprotkb:Q4VWX6|uniprotkb:Q5TDA1|uniprotkb:Q6UQ80|uniprotkb:Q7Z2D8|uniprotkb:Q8IWW3|uniprotkb:Q8IWW4|uniprotkb:Q9UCZ4|uniprotkb:Q9UN57|uniprotkb:G8XRH6|ensembl:ENSP00000328264|uniprotkb:E7EWZ3	intact:EBI-6656055	psi-mi:oprm_human(display_long)|uniprotkb:OPRM1(gene name)|psi-mi:OPRM1(display_short)|uniprotkb:MOR1(gene name synonym)|uniprotkb:Mu opioid receptor(gene name synonym)|uniprotkb:Mu opiate receptor(gene name synonym)	psi-mi:p01210-pro_0000008243(display_long)|uniprotkb:PENK(gene name)|psi-mi:PENK(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656094|imex:IM-20536-46	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272453.1|refseq:NP_001272455.1|refseq:NP_001272456.1|refseq:NP_001272457.1|refseq:NP_001138752.1|refseq:NP_001138753.1|refseq:NP_001272452.1|refseq:NP_000905.3|refseq:NP_001008503.2|refseq:NP_001008504.2|refseq:NP_001008505.2|refseq:NP_001138751.1|refseq:NP_001138754.1|refseq:NP_001138755.1|refseq:NP_001138756.1|refseq:NP_001138757.1|refseq:NP_001138758.1|refseq:NP_001138759.1|refseq:XP_016866395.1|ensembl:ENSG00000112038(gene)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007600"(sensory perception)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031005"(filamin binding)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032094"(response to food)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|ensembl:ENST00000330432(transcript)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038047"(morphine receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004979"(beta-endorphin receptor activity)|go:"GO:0042755"(eating behavior)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0005768"(endosome)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061358"(negative regulation of Wnt protein secretion)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097444"(spine apparatus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000105(Mu opioid receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35372|reactome:R-HSA-111885|reactome:R-HSA-202040|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|reactome:R-HSA-418594|reactome:R-HSA-6785807|reactome:R-HSA-9022699|reactome:R-HSA-375276	intact:EBI-6656032(chain-parent)	-	-	chain-seq-start:100|chain-seq-end:104	figure legend:Table S2-88|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.57x10^-9(molar)	2013/04/23	2014/10/16	rogid:pfkhVhvpn9gSXiBRs1OBXJBCI3s9606	rogid:bz5sbFu/WDiWtYrAxeiR26fZRwg9606	intact-crc:6496D8CCB03C9960|rigid:wVZWiVbWvBXfkEQ/6w3LnOlJtvc	false	-	mutation:2-2|methylated phenylalanine:4-4	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P35372	uniprotkb:P01210-PRO_0000008243	intact:EBI-2624570|uniprotkb:B0FXJ1|uniprotkb:B8Q1L8|uniprotkb:B8Q1L9|uniprotkb:Q6UPP1|uniprotkb:Q86V80|uniprotkb:G8XRH8|uniprotkb:B2R9S7|uniprotkb:B8Q1L7|uniprotkb:Q12930|uniprotkb:Q4VWM1|uniprotkb:Q4VWM2|uniprotkb:Q4VWM3|uniprotkb:Q4VWM4|uniprotkb:Q4VWM6|uniprotkb:Q4VWX6|uniprotkb:Q5TDA1|uniprotkb:Q6UQ80|uniprotkb:Q7Z2D8|uniprotkb:Q8IWW3|uniprotkb:Q8IWW4|uniprotkb:Q9UCZ4|uniprotkb:Q9UN57|uniprotkb:G8XRH6|ensembl:ENSP00000328264|uniprotkb:E7EWZ3	intact:EBI-6656055	psi-mi:oprm_human(display_long)|uniprotkb:OPRM1(gene name)|psi-mi:OPRM1(display_short)|uniprotkb:MOR1(gene name synonym)|uniprotkb:Mu opioid receptor(gene name synonym)|uniprotkb:Mu opiate receptor(gene name synonym)	psi-mi:p01210-pro_0000008243(display_long)|uniprotkb:PENK(gene name)|psi-mi:PENK(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656094|imex:IM-20536-46	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272453.1|refseq:NP_001272455.1|refseq:NP_001272456.1|refseq:NP_001272457.1|refseq:NP_001138752.1|refseq:NP_001138753.1|refseq:NP_001272452.1|refseq:NP_000905.3|refseq:NP_001008503.2|refseq:NP_001008504.2|refseq:NP_001008505.2|refseq:NP_001138751.1|refseq:NP_001138754.1|refseq:NP_001138755.1|refseq:NP_001138756.1|refseq:NP_001138757.1|refseq:NP_001138758.1|refseq:NP_001138759.1|refseq:XP_016866395.1|ensembl:ENSG00000112038(gene)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007600"(sensory perception)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031005"(filamin binding)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032094"(response to food)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|ensembl:ENST00000330432(transcript)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038047"(morphine receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004979"(beta-endorphin receptor activity)|go:"GO:0042755"(eating behavior)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0005768"(endosome)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061358"(negative regulation of Wnt protein secretion)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097444"(spine apparatus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000105(Mu opioid receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35372|reactome:R-HSA-111885|reactome:R-HSA-202040|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|reactome:R-HSA-418594|reactome:R-HSA-6785807|reactome:R-HSA-9022699|reactome:R-HSA-375276	intact:EBI-6656032(chain-parent)	-	-	chain-seq-start:100|chain-seq-end:104	figure legend:Table S2-88|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.57x10^-9(molar)	2013/04/23	2014/10/16	rogid:pfkhVhvpn9gSXiBRs1OBXJBCI3s9606	rogid:bz5sbFu/WDiWtYrAxeiR26fZRwg9606	intact-crc:6496D8CCB03C9960|rigid:wVZWiVbWvBXfkEQ/6w3LnOlJtvc	false	-	N-methyl-L-phenylalanine:4-4|3h radiolabel:?-?|mutation:5-5|mutation:2-2	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:7514"	uniprotkb:P22303	intact:EBI-6662652	intact:EBI-1637793|uniprotkb:Q16169|uniprotkb:Q86TM9|uniprotkb:Q9BXP7|uniprotkb:A4D2E2|uniprotkb:Q29S23|uniprotkb:Q2M324|uniprotkb:Q504V3|uniprotkb:Q86YX9|uniprotkb:D6W5X7|uniprotkb:B7ZKZ0|uniprotkb:Q53F46|ensembl:ENSP00000394976|ensembl:ENSP00000414858|ensembl:ENSP00000241069	psi-mi:neostigmine(display_short)|psi-mi:"CHEBI:7514"(display_long)	psi-mi:aces_human(display_long)|uniprotkb:ACHE(gene name)|psi-mi:ACHE(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662644|imex:IM-20536-141	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011514530.1|refseq:XP_011514531.1|refseq:NP_000656.1|refseq:NP_056646.1|ensembl:ENSG00000087085|refseq:XP_006716058.1|refseq:NP_001289550.1|refseq:NP_001289551.1|refseq:NP_001269378.1|dip:DIP-1119N|ensembl:ENSG00000087085(gene)|ensembl:ENST00000241069(transcript)|ensembl:ENST00000412389(transcript)|ensembl:ENST00000428317(transcript)|go:"GO:0001507"(acetylcholine catabolic process in synaptic cleft)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0002076"(osteoblast development)|go:"GO:0003990"(acetylcholinesterase activity)|go:"GO:0004104"(cholinesterase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006581"(acetylcholine catabolic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0017171"(serine hydrolase activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032223"(negative regulation of synaptic transmission, cholinergic)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043236"(laminin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000997(Cholinesterase)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR014788(Acetylcholinesterase, tetramerisation)|interpro:IPR019819|interpro:IPR019826|interpro:IPR029058|rcsb pdb:1B41|rcsb pdb:1F8U|rcsb pdb:1PUV|rcsb pdb:1PUW|rcsb pdb:1VZJ|rcsb pdb:2CLJ|rcsb pdb:2X8B|rcsb pdb:3LII|rcsb pdb:4BDT|rcsb pdb:4EY4|rcsb pdb:4EY5|rcsb pdb:4EY6|rcsb pdb:4EY7|rcsb pdb:4EY8|rcsb pdb:4M0E|rcsb pdb:4M0F|rcsb pdb:4PQE|rcsb pdb:5FOQ|rcsb pdb:5FPQ|rcsb pdb:5HF5|rcsb pdb:5HF6|rcsb pdb:5HF8|rcsb pdb:5HF9|rcsb pdb:5HFA|rcsb pdb:6CQT|rcsb pdb:6CQU|rcsb pdb:6CQV|rcsb pdb:6CQW|rcsb pdb:6CQX|rcsb pdb:6CQY|rcsb pdb:6CQZ|rcsb pdb:6F25|rcsb pdb:6NEA|rcsb pdb:6NTG|rcsb pdb:6NTH|rcsb pdb:6NTK|rcsb pdb:6NTL|rcsb pdb:6NTM|rcsb pdb:6NTN|rcsb pdb:6NTO|rcsb pdb:6O4W|rcsb pdb:6O4X|rcsb pdb:6O50|rcsb pdb:6O52|rcsb pdb:6O5R|rcsb pdb:6O5S|rcsb pdb:6O5V|rcsb pdb:6O66|rcsb pdb:6O69|rcsb pdb:6U34|rcsb pdb:6U37|rcsb pdb:6U3P|rcsb pdb:6WUV|rcsb pdb:6WUY|rcsb pdb:6WUZ|rcsb pdb:6WV1|rcsb pdb:6WVC|rcsb pdb:6WVO|rcsb pdb:6WVP|rcsb pdb:6WVQ|rcsb pdb:6ZWE|reactome:R-HSA-112311|reactome:R-HSA-1483191|reactome:R-HSA-422085	-	-	-	figure legend:Table S2-138|caution:"The authors have confirmed that the substrate  described as \"acetyl-6-methylthiocholine\", is really acetyl-(beta-methyl)thiocholine, and that  the iodide salt was used (CHEBI:73545)."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.022x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:7JpI1FosTcbuldkkW4tg62j1piE9606	intact-crc:5EDCEE47F3B8BA82	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73475"	uniprotkb:P22303	intact:EBI-6662740	intact:EBI-1637793|uniprotkb:Q16169|uniprotkb:Q86TM9|uniprotkb:Q9BXP7|uniprotkb:A4D2E2|uniprotkb:Q29S23|uniprotkb:Q2M324|uniprotkb:Q504V3|uniprotkb:Q86YX9|uniprotkb:D6W5X7|uniprotkb:B7ZKZ0|uniprotkb:Q53F46|ensembl:ENSP00000394976|ensembl:ENSP00000414858|ensembl:ENSP00000241069	psi-mi:acetyl-beta-methyl-thiocholine(display_short)|psi-mi:"CHEBI:73475"(display_long)	psi-mi:aces_human(display_long)|uniprotkb:ACHE(gene name)|psi-mi:ACHE(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662644|imex:IM-20536-141	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011514530.1|refseq:XP_011514531.1|refseq:NP_000656.1|refseq:NP_056646.1|ensembl:ENSG00000087085|refseq:XP_006716058.1|refseq:NP_001289550.1|refseq:NP_001289551.1|refseq:NP_001269378.1|dip:DIP-1119N|ensembl:ENSG00000087085(gene)|ensembl:ENST00000241069(transcript)|ensembl:ENST00000412389(transcript)|ensembl:ENST00000428317(transcript)|go:"GO:0001507"(acetylcholine catabolic process in synaptic cleft)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0002076"(osteoblast development)|go:"GO:0003990"(acetylcholinesterase activity)|go:"GO:0004104"(cholinesterase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006581"(acetylcholine catabolic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0017171"(serine hydrolase activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032223"(negative regulation of synaptic transmission, cholinergic)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043236"(laminin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000997(Cholinesterase)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR014788(Acetylcholinesterase, tetramerisation)|interpro:IPR019819|interpro:IPR019826|interpro:IPR029058|rcsb pdb:1B41|rcsb pdb:1F8U|rcsb pdb:1PUV|rcsb pdb:1PUW|rcsb pdb:1VZJ|rcsb pdb:2CLJ|rcsb pdb:2X8B|rcsb pdb:3LII|rcsb pdb:4BDT|rcsb pdb:4EY4|rcsb pdb:4EY5|rcsb pdb:4EY6|rcsb pdb:4EY7|rcsb pdb:4EY8|rcsb pdb:4M0E|rcsb pdb:4M0F|rcsb pdb:4PQE|rcsb pdb:5FOQ|rcsb pdb:5FPQ|rcsb pdb:5HF5|rcsb pdb:5HF6|rcsb pdb:5HF8|rcsb pdb:5HF9|rcsb pdb:5HFA|rcsb pdb:6CQT|rcsb pdb:6CQU|rcsb pdb:6CQV|rcsb pdb:6CQW|rcsb pdb:6CQX|rcsb pdb:6CQY|rcsb pdb:6CQZ|rcsb pdb:6F25|rcsb pdb:6NEA|rcsb pdb:6NTG|rcsb pdb:6NTH|rcsb pdb:6NTK|rcsb pdb:6NTL|rcsb pdb:6NTM|rcsb pdb:6NTN|rcsb pdb:6NTO|rcsb pdb:6O4W|rcsb pdb:6O4X|rcsb pdb:6O50|rcsb pdb:6O52|rcsb pdb:6O5R|rcsb pdb:6O5S|rcsb pdb:6O5V|rcsb pdb:6O66|rcsb pdb:6O69|rcsb pdb:6U34|rcsb pdb:6U37|rcsb pdb:6U3P|rcsb pdb:6WUV|rcsb pdb:6WUY|rcsb pdb:6WUZ|rcsb pdb:6WV1|rcsb pdb:6WVC|rcsb pdb:6WVO|rcsb pdb:6WVP|rcsb pdb:6WVQ|rcsb pdb:6ZWE|reactome:R-HSA-112311|reactome:R-HSA-1483191|reactome:R-HSA-422085	-	-	-	figure legend:Table S2-138|caution:"The authors have confirmed that the substrate  described as \"acetyl-6-methylthiocholine\", is really acetyl-(beta-methyl)thiocholine, and that  the iodide salt was used (CHEBI:73545)."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.022x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:7JpI1FosTcbuldkkW4tg62j1piE9606	intact-crc:5EDCEE47F3B8BA82	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P51681	uniprotkb:P13236-PRO_0000005165	intact:EBI-489374|uniprotkb:O14692|uniprotkb:O14693|uniprotkb:O14695|uniprotkb:O14696|uniprotkb:O14697|uniprotkb:O14698|uniprotkb:O14699|uniprotkb:O14700|uniprotkb:O14701|uniprotkb:O14702|uniprotkb:O14703|uniprotkb:O14704|uniprotkb:O14705|uniprotkb:O14706|uniprotkb:O14707|uniprotkb:O14708|uniprotkb:O15538|uniprotkb:Q9UPA4|ensembl:ENSP00000292303|ensembl:ENSP00000404881	intact:EBI-6625160	psi-mi:ccr5_human(display_long)|uniprotkb:HIV-1 fusion coreceptor(gene name synonym)|uniprotkb:CHEMR13(gene name synonym)|uniprotkb:CCR5(gene name)|psi-mi:CCR5(display_short)|uniprotkb:CMKBR5(gene name synonym)	psi-mi:p13236-pro_0000005165(display_long)|uniprotkb:CCL4(gene name)|psi-mi:CCL4(display_short)|uniprotkb:LAG1(gene name synonym)|uniprotkb:MIP1B(gene name synonym)|uniprotkb:SCYA4(gene name synonym)|uniprotkb:G-26 T-lymphocyte-secreted protein(gene name synonym)|uniprotkb:HC21(gene name synonym)|uniprotkb:Lymphocyte activation gene 1 protein(gene name synonym)|uniprotkb:"MIP-1-beta(1-69)"(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-beta(gene name synonym)|uniprotkb:PAT 744(gene name synonym)|uniprotkb:Protein H400(gene name synonym)|uniprotkb:SIS-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine A4(gene name synonym)|uniprotkb:T-cell activation protein 2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6625100|imex:IM-20536-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019722"(calcium-mediated signaling)|refseq:NP_000570.1|refseq:NP_001093638.1|ensembl:ENSG00000160791(gene)|ensembl:ENST00000292303(transcript)|ensembl:ENST00000445772(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016493"(C-C chemokine receptor activity)|rcsb pdb:4MBS|rcsb pdb:5UIW|rcsb pdb:5YD3|rcsb pdb:5YD4|rcsb pdb:5YD5|rcsb pdb:5YY4|rcsb pdb:6FGP|rcsb pdb:6MEO|rcsb pdb:6MET|rcsb pdb:7O7F|reactome:R-HSA-173107|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:2RRS|go:"GO:0023052"(signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002240(C-C chemokine receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P51681|rcsb pdb:1ND8|rcsb pdb:1NE0|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:2L87|go:"GO:0019957"(C-C chemokine binding)|rcsb pdb:2MZX|rcsb pdb:2RLL|dip:DIP-5866N	intact:EBI-2873970(chain-parent)	-	-	chain-seq-start:26|chain-seq-end:92	figure legend:Table S2-53|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.37x10^-9(molar)	2013/04/23	2014/10/16	rogid:qpXGapPDi9co6c1kf2NgfM1qkA89606	rogid:Xy0Ic9Q5Kh9dTxlbD48VPGDPKDY9606	intact-crc:6782E02EA497DDE2|rigid:L2g4/kDCtU73smGpUVpWMDtaUZc	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P51681	uniprotkb:P13236-PRO_0000005165	intact:EBI-489374|uniprotkb:O14692|uniprotkb:O14693|uniprotkb:O14695|uniprotkb:O14696|uniprotkb:O14697|uniprotkb:O14698|uniprotkb:O14699|uniprotkb:O14700|uniprotkb:O14701|uniprotkb:O14702|uniprotkb:O14703|uniprotkb:O14704|uniprotkb:O14705|uniprotkb:O14706|uniprotkb:O14707|uniprotkb:O14708|uniprotkb:O15538|uniprotkb:Q9UPA4|ensembl:ENSP00000292303|ensembl:ENSP00000404881	intact:EBI-6625160	psi-mi:ccr5_human(display_long)|uniprotkb:HIV-1 fusion coreceptor(gene name synonym)|uniprotkb:CHEMR13(gene name synonym)|uniprotkb:CCR5(gene name)|psi-mi:CCR5(display_short)|uniprotkb:CMKBR5(gene name synonym)	psi-mi:p13236-pro_0000005165(display_long)|uniprotkb:CCL4(gene name)|psi-mi:CCL4(display_short)|uniprotkb:LAG1(gene name synonym)|uniprotkb:MIP1B(gene name synonym)|uniprotkb:SCYA4(gene name synonym)|uniprotkb:G-26 T-lymphocyte-secreted protein(gene name synonym)|uniprotkb:HC21(gene name synonym)|uniprotkb:Lymphocyte activation gene 1 protein(gene name synonym)|uniprotkb:"MIP-1-beta(1-69)"(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-beta(gene name synonym)|uniprotkb:PAT 744(gene name synonym)|uniprotkb:Protein H400(gene name synonym)|uniprotkb:SIS-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine A4(gene name synonym)|uniprotkb:T-cell activation protein 2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6625100|imex:IM-20536-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019722"(calcium-mediated signaling)|refseq:NP_000570.1|refseq:NP_001093638.1|ensembl:ENSG00000160791(gene)|ensembl:ENST00000292303(transcript)|ensembl:ENST00000445772(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016493"(C-C chemokine receptor activity)|rcsb pdb:4MBS|rcsb pdb:5UIW|rcsb pdb:5YD3|rcsb pdb:5YD4|rcsb pdb:5YD5|rcsb pdb:5YY4|rcsb pdb:6FGP|rcsb pdb:6MEO|rcsb pdb:6MET|rcsb pdb:7O7F|reactome:R-HSA-173107|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:2RRS|go:"GO:0023052"(signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002240(C-C chemokine receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P51681|rcsb pdb:1ND8|rcsb pdb:1NE0|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:2L87|go:"GO:0019957"(C-C chemokine binding)|rcsb pdb:2MZX|rcsb pdb:2RLL|dip:DIP-5866N	intact:EBI-2873970(chain-parent)	-	-	chain-seq-start:26|chain-seq-end:92	figure legend:Table S2-53|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.37x10^-9(molar)	2013/04/23	2014/10/16	rogid:qpXGapPDi9co6c1kf2NgfM1qkA89606	rogid:Xy0Ic9Q5Kh9dTxlbD48VPGDPKDY9606	intact-crc:6782E02EA497DDE2|rigid:L2g4/kDCtU73smGpUVpWMDtaUZc	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:8247"	uniprotkb:P11229	intact:EBI-6655159	intact:EBI-2624759|ensembl:ENSP00000306490|uniprotkb:Q96RH1	psi-mi:pirenzepine/gastrozepin(display_short)|psi-mi:"CHEBI:8247"(display_long)	psi-mi:acm1_human(display_long)|uniprotkb:CHRM1(gene name)|psi-mi:CHRM1(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655151|imex:IM-20536-86	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000168539(gene)|ensembl:ENST00000306960(transcript)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007399"(nervous system development)|refseq:XP_011543044.1|refseq:NP_000729.2|go:"GO:0016020"(membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043679"(axon terminus)|go:"GO:0045202"(synapse)|go:"GO:0046541"(saliva secretion)|go:"GO:0050890"(cognition)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002228(Muscarinic acetylcholine receptor M1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5CXV|rcsb pdb:6OIJ|rcsb pdb:6WJC|reactome:R-HSA-390648|reactome:R-HSA-416476|interpro:IPR000995(Muscarinic acetylcholine receptor)	-	-	-	figure legend:Table S2-61|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:11.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:h4KvtChdArk35BJmdzgVwGfbc4A9606	intact-crc:46C1540A515BFDEF	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:8247"	uniprotkb:P11229	intact:EBI-6655159	intact:EBI-2624759|ensembl:ENSP00000306490|uniprotkb:Q96RH1	psi-mi:pirenzepine/gastrozepin(display_short)|psi-mi:"CHEBI:8247"(display_long)	psi-mi:acm1_human(display_long)|uniprotkb:CHRM1(gene name)|psi-mi:CHRM1(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655151|imex:IM-20536-86	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000168539(gene)|ensembl:ENST00000306960(transcript)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007399"(nervous system development)|refseq:XP_011543044.1|refseq:NP_000729.2|go:"GO:0016020"(membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043679"(axon terminus)|go:"GO:0045202"(synapse)|go:"GO:0046541"(saliva secretion)|go:"GO:0050890"(cognition)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002228(Muscarinic acetylcholine receptor M1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5CXV|rcsb pdb:6OIJ|rcsb pdb:6WJC|reactome:R-HSA-390648|reactome:R-HSA-416476|interpro:IPR000995(Muscarinic acetylcholine receptor)	-	-	-	figure legend:Table S2-61|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:11.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:h4KvtChdArk35BJmdzgVwGfbc4A9606	intact-crc:46C1540A515BFDEF	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P32241	uniprotkb:P01282-PRO_0000011460	intact:EBI-3917984|uniprotkb:A5JUT9|uniprotkb:Q15871|uniprotkb:Q6P2M6|uniprotkb:B3KPV1|uniprotkb:B4DGI4|uniprotkb:F5H1F5|uniprotkb:G3V0I1|uniprotkb:B4DEB5|ensembl:ENSP00000327246	intact:EBI-6656819	psi-mi:vipr1_human(display_long)|uniprotkb:VIPR1(gene name)|psi-mi:VIPR1(display_short)|uniprotkb:Pituitary adenylate cyclase-activating polypeptide type II receptor(gene name synonym)|uniprotkb:VPAC1(gene name synonym)	psi-mi:p01282-pro_0000011460(display_long)|uniprotkb:VIP(gene name)|psi-mi:VIP(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656811|imex:IM-20536-50	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004615.2|refseq:NP_001238812.1|refseq:NP_001238811.1|refseq:NP_001238813.1|refseq:NP_001238814.1|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001571(GPCR, family 2, vasoactive intestinal peptide receptor)|interpro:IPR001771(GPCR, family 2, vasoactive intestinal peptide receptor 1)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3DTX|rcsb pdb:3HCV|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:6VN7|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|go:"GO:0043235"(receptor complex)|ensembl:ENSG00000114812(gene)|ensembl:ENST00000325123(transcript)|go:"GO:0004999"(vasoactive intestinal polypeptide receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0017046"(peptide hormone binding)|refseq:XP_005265495.1|refseq:XP_011532381.1	intact:EBI-751454(chain-parent)	-	-	chain-seq-start:125|chain-seq-end:152	figure legend:Table S2-114|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:3.6x10^-9(molar)	2013/04/23	2014/10/16	rogid:DBdFfrPCE6B+JrkT9HLBrn09l0k9606	rogid:Ig8+sQ7x2wnattJ+N1G6SY+8xYA9606	intact-crc:15E88D42DEFA0E05|rigid:JpvVSVw2eW03a9JeMT5dMjYJ6po	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P32241	uniprotkb:P01282-PRO_0000011460	intact:EBI-3917984|uniprotkb:A5JUT9|uniprotkb:Q15871|uniprotkb:Q6P2M6|uniprotkb:B3KPV1|uniprotkb:B4DGI4|uniprotkb:F5H1F5|uniprotkb:G3V0I1|uniprotkb:B4DEB5|ensembl:ENSP00000327246	intact:EBI-6656819	psi-mi:vipr1_human(display_long)|uniprotkb:VIPR1(gene name)|psi-mi:VIPR1(display_short)|uniprotkb:Pituitary adenylate cyclase-activating polypeptide type II receptor(gene name synonym)|uniprotkb:VPAC1(gene name synonym)	psi-mi:p01282-pro_0000011460(display_long)|uniprotkb:VIP(gene name)|psi-mi:VIP(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656811|imex:IM-20536-50	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004615.2|refseq:NP_001238812.1|refseq:NP_001238811.1|refseq:NP_001238813.1|refseq:NP_001238814.1|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001571(GPCR, family 2, vasoactive intestinal peptide receptor)|interpro:IPR001771(GPCR, family 2, vasoactive intestinal peptide receptor 1)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3DTX|rcsb pdb:3HCV|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:6VN7|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|go:"GO:0043235"(receptor complex)|ensembl:ENSG00000114812(gene)|ensembl:ENST00000325123(transcript)|go:"GO:0004999"(vasoactive intestinal polypeptide receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0017046"(peptide hormone binding)|refseq:XP_005265495.1|refseq:XP_011532381.1	intact:EBI-751454(chain-parent)	-	-	chain-seq-start:125|chain-seq-end:152	figure legend:Table S2-114|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:3.6x10^-9(molar)	2013/04/23	2014/10/16	rogid:DBdFfrPCE6B+JrkT9HLBrn09l0k9606	rogid:Ig8+sQ7x2wnattJ+N1G6SY+8xYA9606	intact-crc:15E88D42DEFA0E05|rigid:JpvVSVw2eW03a9JeMT5dMjYJ6po	false	-	3h radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25025	uniprotkb:P10145	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-3917999|uniprotkb:Q9UCS0|uniprotkb:Q9UCR8|uniprotkb:Q9C077|uniprotkb:Q6FGF6|uniprotkb:Q96RG6|uniprotkb:B2R4L8|uniprotkb:Q9UCE1|uniprotkb:Q9UCR9|uniprotkb:Q6LAE6|ensembl:ENSP00000306512	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:il8_human(display_long)|uniprotkb:Protein 3-10C(gene name synonym)|uniprotkb:T-cell chemotactic factor(gene name synonym)|uniprotkb:CXCL8(gene name)|psi-mi:CXCL8(display_short)|uniprotkb:C-X-C motif chemokine 8(gene name synonym)|uniprotkb:"Chemokine (C-X-C motif) ligand 8"(gene name synonym)|uniprotkb:Emoctakin(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 1(gene name synonym)|uniprotkb:IL8(gene name synonym)|uniprotkb:Monocyte-derived neutrophil chemotactic factor(gene name synonym)|uniprotkb:Monocyte-derived neutrophil-activating peptide(gene name synonym)|uniprotkb:Neutrophil-activating protein 1(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624928|imex:IM-20536-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	refseq:NP_000575.1|ensembl:ENSG00000169429(gene)|ensembl:ENST00000307407(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005153"(interleukin-8 receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-6785807|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031623"(receptor internalization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042119"(neutrophil activation)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045091"(regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006935"(chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR028469|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1ICW|rcsb pdb:1IKL|rcsb pdb:1IKM|rcsb pdb:1IL8|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|rcsb pdb:1ILQ|rcsb pdb:1QE6|rcsb pdb:1ROD|rcsb pdb:2IL8|rcsb pdb:3IL8|rcsb pdb:4XDX|rcsb pdb:5D14|rcsb pdb:5WDZ|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6N2U|rcsb pdb:6WZM|reactome:R-HSA-2559582|reactome:R-HSA-375276|rcsb pdb:1ILP|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-3778N	-	-	-	figure legend:Table S2-49|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.46x10^-9(molar)	2013/04/23	2014/10/16	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:aC4GQA1hEtGxhjdfmoeStVe8Mf09606	intact-crc:E1FB13FA43A9FF84|rigid:e4uyUXs6BKclebixsy3U0ow4peY	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25025	uniprotkb:P10145	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-3917999|uniprotkb:Q9UCS0|uniprotkb:Q9UCR8|uniprotkb:Q9C077|uniprotkb:Q6FGF6|uniprotkb:Q96RG6|uniprotkb:B2R4L8|uniprotkb:Q9UCE1|uniprotkb:Q9UCR9|uniprotkb:Q6LAE6|ensembl:ENSP00000306512	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:il8_human(display_long)|uniprotkb:Protein 3-10C(gene name synonym)|uniprotkb:T-cell chemotactic factor(gene name synonym)|uniprotkb:CXCL8(gene name)|psi-mi:CXCL8(display_short)|uniprotkb:C-X-C motif chemokine 8(gene name synonym)|uniprotkb:"Chemokine (C-X-C motif) ligand 8"(gene name synonym)|uniprotkb:Emoctakin(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 1(gene name synonym)|uniprotkb:IL8(gene name synonym)|uniprotkb:Monocyte-derived neutrophil chemotactic factor(gene name synonym)|uniprotkb:Monocyte-derived neutrophil-activating peptide(gene name synonym)|uniprotkb:Neutrophil-activating protein 1(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624928|imex:IM-20536-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	refseq:NP_000575.1|ensembl:ENSG00000169429(gene)|ensembl:ENST00000307407(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005153"(interleukin-8 receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-6785807|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031623"(receptor internalization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042119"(neutrophil activation)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045091"(regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006935"(chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR028469|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1ICW|rcsb pdb:1IKL|rcsb pdb:1IKM|rcsb pdb:1IL8|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|rcsb pdb:1ILQ|rcsb pdb:1QE6|rcsb pdb:1ROD|rcsb pdb:2IL8|rcsb pdb:3IL8|rcsb pdb:4XDX|rcsb pdb:5D14|rcsb pdb:5WDZ|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6N2U|rcsb pdb:6WZM|reactome:R-HSA-2559582|reactome:R-HSA-375276|rcsb pdb:1ILP|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-3778N	-	-	-	figure legend:Table S2-49|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.46x10^-9(molar)	2013/04/23	2014/10/16	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:aC4GQA1hEtGxhjdfmoeStVe8Mf09606	intact-crc:E1FB13FA43A9FF84|rigid:e4uyUXs6BKclebixsy3U0ow4peY	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28229"	uniprotkb:P35228	intact:EBI-6662311	intact:EBI-6662224|uniprotkb:A1L3U5|uniprotkb:B7ZLY2|uniprotkb:O60757|uniprotkb:O94994|uniprotkb:Q16263|uniprotkb:Q16692|uniprotkb:Q4TTS5|uniprotkb:Q9UD42|ensembl:ENSP00000327251	psi-mi:l-nmma(display_short)|psi-mi:"CHEBI:28229"(display_long)	psi-mi:nos2_human(display_long)|uniprotkb:NOS2(gene name)|psi-mi:NOS2(display_short)|uniprotkb:NOS2A(gene name synonym)|uniprotkb:Hepatocyte NOS(gene name synonym)|uniprotkb:Inducible NO synthase(gene name synonym)|uniprotkb:NOS type II(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662325|imex:IM-20536-136	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011523161.1|refseq:NP_000616.3|dip:DIP-59359N|ensembl:ENSG00000007171(gene)|ensembl:ENST00000313735(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001912"(positive regulation of leukocyte mediated cytotoxicity)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0020037"(heme binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0032310"(prostaglandin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0035690"|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|rcsb pdb:1NSI|rcsb pdb:2LL6|rcsb pdb:2NSI|rcsb pdb:3E7G|rcsb pdb:3EJ8|rcsb pdb:3HR4|rcsb pdb:4CX7|rcsb pdb:4NOS|rcsb pdb:5TP6|rcsb pdb:5XN3|rcsb pdb:6JWM|rcsb pdb:6JWN|rcsb pdb:6KEY|reactome:R-HSA-1222556|reactome:R-HSA-392154|reactome:R-HSA-6785807|reactome:R-HSA-9033241|reactome:R-HSA-9636249	-	-	-	figure legend:Table S2-134|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.8x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:T1W4KxGaDieo3kQ8OTZjNXA4iF49606	intact-crc:A87F5F24BDDE2CEA	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:16467"	uniprotkb:P35228	intact:EBI-6662307	intact:EBI-6662224|uniprotkb:A1L3U5|uniprotkb:B7ZLY2|uniprotkb:O60757|uniprotkb:O94994|uniprotkb:Q16263|uniprotkb:Q16692|uniprotkb:Q4TTS5|uniprotkb:Q9UD42|ensembl:ENSP00000327251	psi-mi:arginine(display_short)|psi-mi:"CHEBI:16467"(display_long)	psi-mi:nos2_human(display_long)|uniprotkb:NOS2(gene name)|psi-mi:NOS2(display_short)|uniprotkb:NOS2A(gene name synonym)|uniprotkb:Hepatocyte NOS(gene name synonym)|uniprotkb:Inducible NO synthase(gene name synonym)|uniprotkb:NOS type II(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662325|imex:IM-20536-136	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011523161.1|refseq:NP_000616.3|dip:DIP-59359N|ensembl:ENSG00000007171(gene)|ensembl:ENST00000313735(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001912"(positive regulation of leukocyte mediated cytotoxicity)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0020037"(heme binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0032310"(prostaglandin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0035690"|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|rcsb pdb:1NSI|rcsb pdb:2LL6|rcsb pdb:2NSI|rcsb pdb:3E7G|rcsb pdb:3EJ8|rcsb pdb:3HR4|rcsb pdb:4CX7|rcsb pdb:4NOS|rcsb pdb:5TP6|rcsb pdb:5XN3|rcsb pdb:6JWM|rcsb pdb:6JWN|rcsb pdb:6KEY|reactome:R-HSA-1222556|reactome:R-HSA-392154|reactome:R-HSA-6785807|reactome:R-HSA-9033241|reactome:R-HSA-9636249	-	-	-	figure legend:Table S2-134|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.8x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:T1W4KxGaDieo3kQ8OTZjNXA4iF49606	intact-crc:A87F5F24BDDE2CEA	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:34849"	uniprotkb:P10275	intact:EBI-6656801	intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6	psi-mi:mibolerone(display_short)|psi-mi:"CHEBI:34849"(display_long)	psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656791|imex:IM-20536-120	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N	-	-	-	figure legend:Table S2-112|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.8x10^-9(molar)	2013/04/23	2016/03/30	-	rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606	intact-crc:7B5794F3F0BE6332	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:34849"	uniprotkb:P10275	intact:EBI-6656801	intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6	psi-mi:mibolerone(display_short)|psi-mi:"CHEBI:34849"(display_long)	psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656791|imex:IM-20536-120	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N	-	-	-	figure legend:Table S2-112|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.8x10^-9(molar)	2013/04/23	2016/03/30	-	rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606	intact-crc:7B5794F3F0BE6332	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:6762"	uniprotkb:P35367	intact:EBI-6625195	intact:EBI-6595281|ensembl:ENSP00000380247|ensembl:ENSP00000397028|ensembl:ENSP00000406705|uniprotkb:Q6P9E5|uniprotkb:A8K047	psi-mi:pyrilamine(display_short)|psi-mi:"CHEBI:6762"(display_long)	psi-mi:hrh1_human(display_long)|uniprotkb:HRH1(gene name)|psi-mi:HRH1(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6625180|imex:IM-20536-80	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000196639(gene)|ensembl:ENST00000397056(transcript)|ensembl:ENST00000431010(transcript)|ensembl:ENST00000438284(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004969"(histamine receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007613"(memory)|go:"GO:0008542"(visual learning)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048016"(inositol phosphate-mediated signaling)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0071420"(cellular response to histamine)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000921(Histamine H1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:3RZE|rcsb pdb:7DFL|reactome:R-HSA-390650|reactome:R-HSA-416476|go:"GO:0032962"(positive regulation of inositol trisphosphate biosynthetic process)|refseq:XP_011531954.1|refseq:XP_011531955.1|refseq:NP_000852.1|refseq:NP_001091681.1|refseq:NP_001091682.1|refseq:NP_001091683.1|refseq:XP_016861772.1|refseq:XP_016861773.1|dip:DIP-41996N	-	-	-	figure legend:Table S2-55|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:11.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:M/dOvMtHvMlNwA26qSdb5hqV1xQ9606	intact-crc:32E250A9B3758B5F	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:6762"	uniprotkb:P35367	intact:EBI-6625195	intact:EBI-6595281|ensembl:ENSP00000380247|ensembl:ENSP00000397028|ensembl:ENSP00000406705|uniprotkb:Q6P9E5|uniprotkb:A8K047	psi-mi:pyrilamine(display_short)|psi-mi:"CHEBI:6762"(display_long)	psi-mi:hrh1_human(display_long)|uniprotkb:HRH1(gene name)|psi-mi:HRH1(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6625180|imex:IM-20536-80	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000196639(gene)|ensembl:ENST00000397056(transcript)|ensembl:ENST00000431010(transcript)|ensembl:ENST00000438284(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004969"(histamine receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007613"(memory)|go:"GO:0008542"(visual learning)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048016"(inositol phosphate-mediated signaling)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0071420"(cellular response to histamine)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000921(Histamine H1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:3RZE|rcsb pdb:7DFL|reactome:R-HSA-390650|reactome:R-HSA-416476|go:"GO:0032962"(positive regulation of inositol trisphosphate biosynthetic process)|refseq:XP_011531954.1|refseq:XP_011531955.1|refseq:NP_000852.1|refseq:NP_001091681.1|refseq:NP_001091682.1|refseq:NP_001091683.1|refseq:XP_016861772.1|refseq:XP_016861773.1|dip:DIP-41996N	-	-	-	figure legend:Table S2-55|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:11.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:M/dOvMtHvMlNwA26qSdb5hqV1xQ9606	intact-crc:32E250A9B3758B5F	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25103	uniprotkb:P20366-PRO_0000033530	intact:EBI-6655287|ensembl:ENSP00000303522|uniprotkb:A8K150	intact:EBI-6655360	psi-mi:nk1r_human(display_long)|uniprotkb:TACR1(gene name)|psi-mi:TACR1(display_short)|uniprotkb:NK1R(gene name synonym)|uniprotkb:TAC1R(gene name synonym)|uniprotkb:NK-1 receptor(gene name synonym)|uniprotkb:Tachykinin receptor 1(gene name synonym)	psi-mi:p20366-pro_0000033530(display_long)|uniprotkb:TAC1(gene name)|psi-mi:TAC1(display_short)|uniprotkb:NKA(gene name synonym)|uniprotkb:NKNA(gene name synonym)|uniprotkb:TAC2(gene name synonym)|uniprotkb:PPT(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655381|imex:IM-20536-34	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115353(gene)|ensembl:ENST00000305249(transcript)|go:"GO:0004995"(tachykinin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0009582"(detection of abiotic stimulus)|go:"GO:0016496"(substance P receptor activity)|go:"GO:0036126"(sperm flagellum)|go:"GO:0048265"(response to pain)|go:"GO:0061827"(sperm head)|go:"GO:0070472"(regulation of uterine smooth muscle contraction)|go:"GO:0097225"(sperm midpiece)|go:"GO:1902093"(positive regulation of flagellated sperm motility)|interpro:IPR000046(Neurokinin NK1 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001681(Neurokinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KS9|rcsb pdb:2KSA|rcsb pdb:2KSB|rcsb pdb:6E59|rcsb pdb:6HLL|rcsb pdb:6HLO|rcsb pdb:6HLP|reactome:R-HSA-380095|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|refseq:NP_001049.1|refseq:NP_056542.1	intact:EBI-717291(chain-parent)	-	-	chain-seq-start:58|chain-seq-end:68	figure legend:Table S2-72|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.2x10^-9(molar)	2013/04/23	2014/10/16	rogid:Wd5f857uk5oTq9cGzATuRdq6LvE9606	rogid:E0Lo0d8Bsk/3bp7oq6z18KxQdug9606	intact-crc:88532C22E0738D60|rigid:dpsdN3QH4nWOg75fh2mitgTO6C0	false	-	L-methionine sulfone:11-11|3h radiolabel:?-?|methylated glycine:9-9	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25103	uniprotkb:P20366-PRO_0000033530	intact:EBI-6655287|ensembl:ENSP00000303522|uniprotkb:A8K150	intact:EBI-6655360	psi-mi:nk1r_human(display_long)|uniprotkb:TACR1(gene name)|psi-mi:TACR1(display_short)|uniprotkb:NK1R(gene name synonym)|uniprotkb:TAC1R(gene name synonym)|uniprotkb:NK-1 receptor(gene name synonym)|uniprotkb:Tachykinin receptor 1(gene name synonym)	psi-mi:p20366-pro_0000033530(display_long)|uniprotkb:TAC1(gene name)|psi-mi:TAC1(display_short)|uniprotkb:NKA(gene name synonym)|uniprotkb:NKNA(gene name synonym)|uniprotkb:TAC2(gene name synonym)|uniprotkb:PPT(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655381|imex:IM-20536-34	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115353(gene)|ensembl:ENST00000305249(transcript)|go:"GO:0004995"(tachykinin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0009582"(detection of abiotic stimulus)|go:"GO:0016496"(substance P receptor activity)|go:"GO:0036126"(sperm flagellum)|go:"GO:0048265"(response to pain)|go:"GO:0061827"(sperm head)|go:"GO:0070472"(regulation of uterine smooth muscle contraction)|go:"GO:0097225"(sperm midpiece)|go:"GO:1902093"(positive regulation of flagellated sperm motility)|interpro:IPR000046(Neurokinin NK1 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001681(Neurokinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KS9|rcsb pdb:2KSA|rcsb pdb:2KSB|rcsb pdb:6E59|rcsb pdb:6HLL|rcsb pdb:6HLO|rcsb pdb:6HLP|reactome:R-HSA-380095|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|refseq:NP_001049.1|refseq:NP_056542.1	intact:EBI-717291(chain-parent)	-	-	chain-seq-start:58|chain-seq-end:68	figure legend:Table S2-72|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.2x10^-9(molar)	2013/04/23	2014/10/16	rogid:Wd5f857uk5oTq9cGzATuRdq6LvE9606	rogid:E0Lo0d8Bsk/3bp7oq6z18KxQdug9606	intact-crc:88532C22E0738D60|rigid:dpsdN3QH4nWOg75fh2mitgTO6C0	false	-	methylated glycine:9-9|L-methionine sulfone:11-11	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P30989	uniprotkb:P30990-PRO_0000019524	intact:EBI-6655774|ensembl:ENSP00000359532|uniprotkb:Q9H4H1|uniprotkb:Q9H4T5	intact:EBI-6655817	psi-mi:ntr1_human(display_long)|uniprotkb:NTSR1(gene name)|psi-mi:NTSR1(display_short)|uniprotkb:NTRR(gene name synonym)|uniprotkb:High-affinity levocabastine-insensitive neurotensin receptor(gene name synonym)|uniprotkb:NTRH(gene name synonym)	psi-mi:p30990-pro_0000019524(display_long)|uniprotkb:NTS(gene name)|psi-mi:NTS(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655824|imex:IM-20536-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101188(gene)|ensembl:ENST00000370501(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014054"(positive regulation of gamma-aminobutyric acid secretion)|go:"GO:0016492"(G protein-coupled neurotensin receptor activity)|go:"GO:0032280"(symmetric synapse)|go:"GO:0033993"(response to lipid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0071545"(inositol phosphate catabolic process)|go:"GO:0090238"(positive regulation of arachidonic acid secretion)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098900"(regulation of action potential)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003984(Neurotensin receptor)|interpro:IPR003985(Neurotensin type 1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LYW|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6PWC|rcsb pdb:6UP7|reactome:R-HSA-375276|reactome:R-HSA-416476|go:"GO:0043197"(dendritic spine)|refseq:NP_002522.2|dip:DIP-60977N	intact:EBI-6655799(chain-parent)	-	-	chain-seq-start:151|chain-seq-end:163	figure legend:Table S2-81b|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.4x10^-9(molar)	2013/04/23	2014/10/16	rogid:uT00/8k3tTn1EaC7MWQAlibNf589606	rogid:GDDhFTmWE6kC6ipFhUMRV/mpEdQ9606	intact-crc:A68B64ACE072D406|rigid:6CZHfjb/UN1tWWd0FkktW1EFJVU	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P30989	uniprotkb:P30990-PRO_0000019524	intact:EBI-6655774|ensembl:ENSP00000359532|uniprotkb:Q9H4H1|uniprotkb:Q9H4T5	intact:EBI-6655817	psi-mi:ntr1_human(display_long)|uniprotkb:NTSR1(gene name)|psi-mi:NTSR1(display_short)|uniprotkb:NTRR(gene name synonym)|uniprotkb:High-affinity levocabastine-insensitive neurotensin receptor(gene name synonym)|uniprotkb:NTRH(gene name synonym)	psi-mi:p30990-pro_0000019524(display_long)|uniprotkb:NTS(gene name)|psi-mi:NTS(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655824|imex:IM-20536-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101188(gene)|ensembl:ENST00000370501(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014054"(positive regulation of gamma-aminobutyric acid secretion)|go:"GO:0016492"(G protein-coupled neurotensin receptor activity)|go:"GO:0032280"(symmetric synapse)|go:"GO:0033993"(response to lipid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0071545"(inositol phosphate catabolic process)|go:"GO:0090238"(positive regulation of arachidonic acid secretion)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098900"(regulation of action potential)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003984(Neurotensin receptor)|interpro:IPR003985(Neurotensin type 1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LYW|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6PWC|rcsb pdb:6UP7|reactome:R-HSA-375276|reactome:R-HSA-416476|go:"GO:0043197"(dendritic spine)|refseq:NP_002522.2|dip:DIP-60977N	intact:EBI-6655799(chain-parent)	-	-	chain-seq-start:151|chain-seq-end:163	figure legend:Table S2-81b|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.4x10^-9(molar)	2013/04/23	2014/10/16	rogid:uT00/8k3tTn1EaC7MWQAlibNf589606	rogid:GDDhFTmWE6kC6ipFhUMRV/mpEdQ9606	intact-crc:A68B64ACE072D406|rigid:6CZHfjb/UN1tWWd0FkktW1EFJVU	false	-	125i radiolabel:3-3	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73340"	uniprotkb:P08173	intact:EBI-6655199	intact:EBI-6655217|ensembl:ENSP00000409378|ensembl:ENSP00000507561|uniprotkb:B2RPP4|uniprotkb:Q0VD60|uniprotkb:Q4VBK7	psi-mi:4-damp(display_short)|psi-mi:"CHEBI:73340"(display_long)	psi-mi:acm4_human(display_long)|uniprotkb:CHRM4(gene name)|psi-mi:CHRM4(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655209|imex:IM-20536-92	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000180720(gene)|ensembl:ENST00000433765(transcript)|ensembl:ENST00000682254(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001432(Muscarinic acetylcholine receptor M4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|rcsb pdb:5DSG|rcsb pdb:6D9H|rcsb pdb:6KP6|reactome:R-HSA-390648|reactome:R-HSA-418594|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|refseq:NP_000732.2|dip:DIP-61455N	-	-	-	figure legend:Table S2-67|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.5x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:Vl9zYuPmhxVM2yGmmttbZYJNDHM9606	intact-crc:D4CBDAC768589ACC	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73340"	uniprotkb:P08173	intact:EBI-6655199	intact:EBI-6655217|ensembl:ENSP00000409378|ensembl:ENSP00000507561|uniprotkb:B2RPP4|uniprotkb:Q0VD60|uniprotkb:Q4VBK7	psi-mi:4-damp(display_short)|psi-mi:"CHEBI:73340"(display_long)	psi-mi:acm4_human(display_long)|uniprotkb:CHRM4(gene name)|psi-mi:CHRM4(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655209|imex:IM-20536-92	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000180720(gene)|ensembl:ENST00000433765(transcript)|ensembl:ENST00000682254(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001432(Muscarinic acetylcholine receptor M4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|rcsb pdb:5DSG|rcsb pdb:6D9H|rcsb pdb:6KP6|reactome:R-HSA-390648|reactome:R-HSA-418594|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|refseq:NP_000732.2|dip:DIP-61455N	-	-	-	figure legend:Table S2-67|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.5x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:Vl9zYuPmhxVM2yGmmttbZYJNDHM9606	intact-crc:D4CBDAC768589ACC	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73356"	uniprotkb:P41143	intact:EBI-6655858	intact:EBI-2624456|uniprotkb:B5B0B8|ensembl:ENSP00000234961	psi-mi:dpdpe(display_short)|psi-mi:"CHEBI:73356"(display_long)	psi-mi:oprd_human(display_long)|uniprotkb:OPRD1(gene name)|psi-mi:OPRD1(display_short)|uniprotkb:OPRD(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655841|imex:IM-20536-95	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000902.3|ensembl:ENSG00000116329(gene)|ensembl:ENST00000234961(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032590"(dendrite membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038046"(G protein-coupled enkephalin receptor activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043679"(axon terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097444"(spine apparatus)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000321(Delta opioid receptor)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P41143|rcsb pdb:1OZC|rcsb pdb:2IQM|rcsb pdb:4N6H|rcsb pdb:4RWA|rcsb pdb:4RWD|rcsb pdb:6PT2|rcsb pdb:6PT3|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-6785807|go:"GO:0071456"(cellular response to hypoxia)	-	-	-	figure legend:Table S2-83|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:6.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:47Egb9vEVBuRADGdyZqCRPHk5gI9606	intact-crc:BEC9554541976EB4	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73356"	uniprotkb:P41143	intact:EBI-6655858	intact:EBI-2624456|uniprotkb:B5B0B8|ensembl:ENSP00000234961	psi-mi:dpdpe(display_short)|psi-mi:"CHEBI:73356"(display_long)	psi-mi:oprd_human(display_long)|uniprotkb:OPRD1(gene name)|psi-mi:OPRD1(display_short)|uniprotkb:OPRD(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655841|imex:IM-20536-95	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000902.3|ensembl:ENSG00000116329(gene)|ensembl:ENST00000234961(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032590"(dendrite membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038046"(G protein-coupled enkephalin receptor activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043679"(axon terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097444"(spine apparatus)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000321(Delta opioid receptor)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P41143|rcsb pdb:1OZC|rcsb pdb:2IQM|rcsb pdb:4N6H|rcsb pdb:4RWA|rcsb pdb:4RWD|rcsb pdb:6PT2|rcsb pdb:6PT3|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-6785807|go:"GO:0071456"(cellular response to hypoxia)	-	-	-	figure legend:Table S2-83|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:6.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:47Egb9vEVBuRADGdyZqCRPHk5gI9606	intact-crc:BEC9554541976EB4	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:7936"	uniprotkb:P31645	intact:EBI-6661758	intact:EBI-6116107|uniprotkb:Q5EE02|ensembl:ENSP00000261707|ensembl:ENSP00000385822|ensembl:ENSP00000498537	psi-mi:paroxetine(display_short)|psi-mi:"CHEBI:7936"(display_long)	psi-mi:sc6a4_human(display_long)|uniprotkb:SLC6A4(gene name)|psi-mi:SLC6A4(display_short)|uniprotkb:HTT(gene name synonym)|uniprotkb:SERT(gene name synonym)|uniprotkb:5HT transporter(gene name synonym)|uniprotkb:Solute carrier family 6 member 4(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6661508|imex:IM-20536-126	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001036.1|ensembl:ENSG00000108576(gene)|ensembl:ENST00000261707(transcript)|ensembl:ENST00000401766(transcript)|ensembl:ENST00000650711(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005335"("serotonin:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012505"(endomembrane system)|go:"GO:0014064"(positive regulation of serotonin secretion)|go:"GO:0015844"(monoamine transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019811"(cocaine binding)|go:"GO:0021941"(negative regulation of cerebellar granule cell precursor proliferation)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0035176"(social behavior)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0042713"(sperm ejaculation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051378"(serotonin binding)|go:"GO:0051610"(serotonin uptake)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0090067"(regulation of thalamus size)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099154"(serotonergic synapse)|interpro:IPR000175("Sodium:neurotransmitter symporter")|interpro:IPR013086("Sodium:neurotransmitter symporter, serotonin, N-terminal")|interpro:IPR037272|rcsb pdb:5I6X|rcsb pdb:5I6Z|rcsb pdb:5I71|rcsb pdb:5I73|rcsb pdb:5I74|rcsb pdb:5I75|rcsb pdb:6AWN|rcsb pdb:6AWO|rcsb pdb:6AWP|rcsb pdb:6AWQ|rcsb pdb:6DZV|rcsb pdb:6DZW|rcsb pdb:6DZY|rcsb pdb:6DZZ|rcsb pdb:6VRH|rcsb pdb:6VRK|rcsb pdb:6VRL|rcsb pdb:6W2B|rcsb pdb:6W2C|reactome:R-HSA-380615	-	-	-	figure legend:Table S2-124|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:8.3x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:mZYK0YEOl23+K9N0+v10I6r/Y4o9606	intact-crc:BDF70C59A84A7668	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:47499"	uniprotkb:P31645	intact:EBI-6661760	intact:EBI-6116107|uniprotkb:Q5EE02|ensembl:ENSP00000261707|ensembl:ENSP00000385822|ensembl:ENSP00000498537	psi-mi:imipramine(display_short)|psi-mi:"CHEBI:47499"(display_long)	psi-mi:sc6a4_human(display_long)|uniprotkb:SLC6A4(gene name)|psi-mi:SLC6A4(display_short)|uniprotkb:HTT(gene name synonym)|uniprotkb:SERT(gene name synonym)|uniprotkb:5HT transporter(gene name synonym)|uniprotkb:Solute carrier family 6 member 4(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6661508|imex:IM-20536-126	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001036.1|ensembl:ENSG00000108576(gene)|ensembl:ENST00000261707(transcript)|ensembl:ENST00000401766(transcript)|ensembl:ENST00000650711(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005335"("serotonin:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012505"(endomembrane system)|go:"GO:0014064"(positive regulation of serotonin secretion)|go:"GO:0015844"(monoamine transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019811"(cocaine binding)|go:"GO:0021941"(negative regulation of cerebellar granule cell precursor proliferation)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0035176"(social behavior)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0042713"(sperm ejaculation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051378"(serotonin binding)|go:"GO:0051610"(serotonin uptake)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0090067"(regulation of thalamus size)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099154"(serotonergic synapse)|interpro:IPR000175("Sodium:neurotransmitter symporter")|interpro:IPR013086("Sodium:neurotransmitter symporter, serotonin, N-terminal")|interpro:IPR037272|rcsb pdb:5I6X|rcsb pdb:5I6Z|rcsb pdb:5I71|rcsb pdb:5I73|rcsb pdb:5I74|rcsb pdb:5I75|rcsb pdb:6AWN|rcsb pdb:6AWO|rcsb pdb:6AWP|rcsb pdb:6AWQ|rcsb pdb:6DZV|rcsb pdb:6DZW|rcsb pdb:6DZY|rcsb pdb:6DZZ|rcsb pdb:6VRH|rcsb pdb:6VRK|rcsb pdb:6VRL|rcsb pdb:6W2B|rcsb pdb:6W2C|reactome:R-HSA-380615	-	-	-	figure legend:Table S2-124|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:8.3x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:mZYK0YEOl23+K9N0+v10I6r/Y4o9606	intact-crc:BDF70C59A84A7668	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:15843"	uniprotkb:P09917	intact:EBI-6662097	intact:EBI-79934|ensembl:ENSP00000363512|ensembl:ENSP00000484468|uniprotkb:Q5JQ14|uniprotkb:E5FPY5|uniprotkb:E5FPY7|uniprotkb:E5FPY8|uniprotkb:B7ZLS0	psi-mi:arachidonic acid(display_short)|psi-mi:"CHEBI:15843"(display_long)	psi-mi:lox5_human(display_long)|uniprotkb:ALOX5(gene name)|psi-mi:ALOX5(display_short)|uniprotkb:LOG5(gene name synonym)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662204|imex:IM-20536-132	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000012779(gene)|ensembl:ENSG00000275565(gene)|ensembl:ENST00000374391(transcript)|ensembl:ENST00000610656(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0005615"(extracellular space)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0005635"(nuclear envelope)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:0016787"(hydrolase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABV|rcsb pdb:3O8Y|rcsb pdb:3V92|rcsb pdb:3V98|rcsb pdb:3V99|rcsb pdb:6N2W|rcsb pdb:6NCF|reactome:R-HSA-2142688|reactome:R-HSA-2142691|reactome:R-HSA-2142700|go:"GO:0019369"(arachidonic acid metabolic process)|reactome:R-HSA-6785807|reactome:R-HSA-9023661|reactome:R-HSA-9026286|reactome:R-HSA-9026290|reactome:R-HSA-9026403|reactome:R-HSA-9027604|reactome:R-HSA-6798695|reactome:R-HSA-9012546|reactome:R-HSA-9018676|reactome:R-HSA-9018682|reactome:R-HSA-9018896|reactome:R-HSA-9020265|refseq:NP_000689.1|refseq:NP_001307790.1|dip:DIP-30950N|refseq:NP_001243082.1|refseq:NP_001243083.1	-	-	-	figure legend:Table S2-130|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.38x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:kk3yqgz7R/Po68UpJpKJ3Rp6Ws89606	intact-crc:FCEE8DD5E35E9E96	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:7625"	uniprotkb:P09917	intact:EBI-6662210	intact:EBI-79934|ensembl:ENSP00000363512|ensembl:ENSP00000484468|uniprotkb:Q5JQ14|uniprotkb:E5FPY5|uniprotkb:E5FPY7|uniprotkb:E5FPY8|uniprotkb:B7ZLS0	psi-mi:ndga_dihydronorguaiaretic acid(display_short)|psi-mi:"CHEBI:7625"(display_long)	psi-mi:lox5_human(display_long)|uniprotkb:ALOX5(gene name)|psi-mi:ALOX5(display_short)|uniprotkb:LOG5(gene name synonym)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662204|imex:IM-20536-132	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000012779(gene)|ensembl:ENSG00000275565(gene)|ensembl:ENST00000374391(transcript)|ensembl:ENST00000610656(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0005615"(extracellular space)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0005635"(nuclear envelope)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:0016787"(hydrolase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABV|rcsb pdb:3O8Y|rcsb pdb:3V92|rcsb pdb:3V98|rcsb pdb:3V99|rcsb pdb:6N2W|rcsb pdb:6NCF|reactome:R-HSA-2142688|reactome:R-HSA-2142691|reactome:R-HSA-2142700|go:"GO:0019369"(arachidonic acid metabolic process)|reactome:R-HSA-6785807|reactome:R-HSA-9023661|reactome:R-HSA-9026286|reactome:R-HSA-9026290|reactome:R-HSA-9026403|reactome:R-HSA-9027604|reactome:R-HSA-6798695|reactome:R-HSA-9012546|reactome:R-HSA-9018676|reactome:R-HSA-9018682|reactome:R-HSA-9018896|reactome:R-HSA-9020265|refseq:NP_000689.1|refseq:NP_001307790.1|dip:DIP-30950N|refseq:NP_001243082.1|refseq:NP_001243083.1	-	-	-	figure legend:Table S2-130|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.38x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:kk3yqgz7R/Po68UpJpKJ3Rp6Ws89606	intact-crc:FCEE8DD5E35E9E96	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28790"	uniprotkb:P28222	intact:EBI-6656313	intact:EBI-1056863|uniprotkb:Q4VAY7|ensembl:ENSP00000358963	psi-mi:serotonin(display_short)|psi-mi:"CHEBI:28790"(display_long)	psi-mi:5ht1b_human(display_long)|uniprotkb:HTR1B(gene name)|psi-mi:HTR1B(display_short)|uniprotkb:HTR1DB(gene name synonym)|uniprotkb:Serotonin receptor 1B(gene name synonym)|uniprotkb:Serotonin 1D beta receptor(gene name synonym)|uniprotkb:S12(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656302|imex:IM-20536-101	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000854.1|ensembl:ENSG00000135312(gene)|ensembl:ENST00000369947(transcript)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014053"(negative regulation of gamma-aminobutyric acid secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0030425"(dendrite)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0035690"|go:"GO:0042220"(response to cocaine)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042756"(drinking behavior)|go:"GO:0044305"(calyx of Held)|go:"GO:0045471"(response to ethanol)|go:"GO:0046849"(bone remodeling)|go:"GO:0050795"(regulation of behavior)|go:"GO:0051378"(serotonin binding)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071502"(cellular response to temperature stimulus)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099154"(serotonergic synapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002147(5-Hydroxytryptamine 1B receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2G1X|rcsb pdb:4IAQ|rcsb pdb:4IAR|rcsb pdb:5V54|rcsb pdb:6G79|rcsb pdb:7C61|reactome:R-HSA-390666|reactome:R-HSA-418594|go:"GO:0030594"(neurotransmitter receptor activity)	-	-	-	figure legend:Table S2-93|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:46.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:KFPTq2aY7OgpBIAdtvUbOX5mnv49606	intact-crc:143530883F59BBA3	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73370"	uniprotkb:P28222	intact:EBI-6656310	intact:EBI-1056863|uniprotkb:Q4VAY7|ensembl:ENSP00000358963	psi-mi:iodocyanopindolol/cyp(display_short)|psi-mi:"CHEBI:73370"(display_long)	psi-mi:5ht1b_human(display_long)|uniprotkb:HTR1B(gene name)|psi-mi:HTR1B(display_short)|uniprotkb:HTR1DB(gene name synonym)|uniprotkb:Serotonin receptor 1B(gene name synonym)|uniprotkb:Serotonin 1D beta receptor(gene name synonym)|uniprotkb:S12(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656302|imex:IM-20536-101	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000854.1|ensembl:ENSG00000135312(gene)|ensembl:ENST00000369947(transcript)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014053"(negative regulation of gamma-aminobutyric acid secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0030425"(dendrite)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0035690"|go:"GO:0042220"(response to cocaine)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042756"(drinking behavior)|go:"GO:0044305"(calyx of Held)|go:"GO:0045471"(response to ethanol)|go:"GO:0046849"(bone remodeling)|go:"GO:0050795"(regulation of behavior)|go:"GO:0051378"(serotonin binding)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071502"(cellular response to temperature stimulus)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099154"(serotonergic synapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002147(5-Hydroxytryptamine 1B receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2G1X|rcsb pdb:4IAQ|rcsb pdb:4IAR|rcsb pdb:5V54|rcsb pdb:6G79|rcsb pdb:7C61|reactome:R-HSA-390666|reactome:R-HSA-418594|go:"GO:0030594"(neurotransmitter receptor activity)	-	-	-	figure legend:Table S2-93|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:46.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:KFPTq2aY7OgpBIAdtvUbOX5mnv49606	intact-crc:143530883F59BBA3	false	125i radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73472"	uniprotkb:P21397	intact:EBI-6662560	intact:EBI-1190845|uniprotkb:Q16426|uniprotkb:B4DF46|ensembl:ENSP00000340684	psi-mi:kynuramine(display_short)|psi-mi:"CHEBI:73472"(display_long)	psi-mi:aofa_human(display_long)|uniprotkb:MAOA(gene name)|psi-mi:MAOA(display_short)|uniprotkb:Monoamine oxidase type A(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662549|imex:IM-20536-137	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000231.1|refseq:NP_001257387.1|ensembl:ENSG00000189221(gene)|ensembl:ENST00000338702(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042135"(neurotransmitter catabolic process)|go:"GO:0042420"(dopamine catabolic process)|go:"GO:0097621"(monoamine oxidase activity)|interpro:IPR001613(Flavin-containing amine oxidase)|interpro:IPR002937(Amine oxidase)|interpro:IPR036188|mint:P21397|rcsb pdb:1H8Q|rcsb pdb:2BXR|rcsb pdb:2BXS|rcsb pdb:2Z5X|rcsb pdb:2Z5Y|reactome:R-HSA-141333|reactome:R-HSA-181430|reactome:R-HSA-379397|reactome:R-HSA-379398|reactome:R-HSA-380612|reactome:R-HSA-5579012|reactome:R-HSA-6785807	-	-	-	figure legend:Table S2-134|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.011x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:I1KqinKud3ZwsSxYy04XYSoqaF09606	intact-crc:F2EAADF1797C9B07	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:3763"	uniprotkb:P21397	intact:EBI-6662562	intact:EBI-1190845|uniprotkb:Q16426|uniprotkb:B4DF46|ensembl:ENSP00000340684	psi-mi:clorgyline(display_short)|psi-mi:"CHEBI:3763"(display_long)	psi-mi:aofa_human(display_long)|uniprotkb:MAOA(gene name)|psi-mi:MAOA(display_short)|uniprotkb:Monoamine oxidase type A(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662549|imex:IM-20536-137	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000231.1|refseq:NP_001257387.1|ensembl:ENSG00000189221(gene)|ensembl:ENST00000338702(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042135"(neurotransmitter catabolic process)|go:"GO:0042420"(dopamine catabolic process)|go:"GO:0097621"(monoamine oxidase activity)|interpro:IPR001613(Flavin-containing amine oxidase)|interpro:IPR002937(Amine oxidase)|interpro:IPR036188|mint:P21397|rcsb pdb:1H8Q|rcsb pdb:2BXR|rcsb pdb:2BXS|rcsb pdb:2Z5X|rcsb pdb:2Z5Y|reactome:R-HSA-141333|reactome:R-HSA-181430|reactome:R-HSA-379397|reactome:R-HSA-379398|reactome:R-HSA-380612|reactome:R-HSA-5579012|reactome:R-HSA-6785807	-	-	-	figure legend:Table S2-134|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.011x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:I1KqinKud3ZwsSxYy04XYSoqaF09606	intact-crc:F2EAADF1797C9B07	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73297"	uniprotkb:P21728	intact:EBI-6624520	intact:EBI-6624459|intact:EBI-28969432|ensembl:ENSP00000377353|uniprotkb:B2RA44|uniprotkb:Q4QRJ0	psi-mi:sch_23390(display_short)|psi-mi:"CHEBI:73297"(display_long)	psi-mi:drd1_human(display_long)|uniprotkb:DRD1(gene name)|psi-mi:DRD1(display_short)|uniprotkb:Dopamine D1 receptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624451|imex:IM-20536-76	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000377353|ensembl:ENST00000393752(transcript)|go:"GO:0001588"(dopamine neurotransmitter receptor activity, coupled via Gs)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|ensembl:ENSG00000184845(gene)|go:"GO:0007617"(mating behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035240"(dopamine binding)|go:"GO:0042311"(vasodilation)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001413(Dopamine 1A receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1OZ5|rcsb pdb:7CKW|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CRH|rcsb pdb:7JOZ|go:"GO:0060170"(ciliary membrane)|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7LJC|go:"GO:0071870"(cellular response to catecholamine stimulus)|rcsb pdb:7LJD|reactome:R-HSA-390651|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903351"(cellular response to dopamine)|refseq:NP_000785.1	-	-	-	figure legend:Table S2-33|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.59x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:AFtjhLTHlY7MiBUIYqC5/3tHHxg9606	intact-crc:56D1F92FC5728864	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73297"	uniprotkb:P21728	intact:EBI-6624520	intact:EBI-6624459|intact:EBI-28969432|ensembl:ENSP00000377353|uniprotkb:B2RA44|uniprotkb:Q4QRJ0	psi-mi:sch_23390(display_short)|psi-mi:"CHEBI:73297"(display_long)	psi-mi:drd1_human(display_long)|uniprotkb:DRD1(gene name)|psi-mi:DRD1(display_short)|uniprotkb:Dopamine D1 receptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624451|imex:IM-20536-76	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000377353|ensembl:ENST00000393752(transcript)|go:"GO:0001588"(dopamine neurotransmitter receptor activity, coupled via Gs)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|ensembl:ENSG00000184845(gene)|go:"GO:0007617"(mating behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035240"(dopamine binding)|go:"GO:0042311"(vasodilation)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001413(Dopamine 1A receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1OZ5|rcsb pdb:7CKW|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CRH|rcsb pdb:7JOZ|go:"GO:0060170"(ciliary membrane)|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7LJC|go:"GO:0071870"(cellular response to catecholamine stimulus)|rcsb pdb:7LJD|reactome:R-HSA-390651|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903351"(cellular response to dopamine)|refseq:NP_000785.1	-	-	-	figure legend:Table S2-33|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.59x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:AFtjhLTHlY7MiBUIYqC5/3tHHxg9606	intact-crc:56D1F92FC5728864	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73357"	uniprotkb:P41145	intact:EBI-6655933	intact:EBI-925028|uniprotkb:Q499G4|uniprotkb:E5RHC9|ensembl:ENSP00000265572|ensembl:ENSP00000429706	psi-mi:u69593(display_short)|psi-mi:"CHEBI:73357"(display_long)	psi-mi:oprk_human(display_long)|uniprotkb:OPRK1(gene name)|psi-mi:OPRK1(display_short)|uniprotkb:OPRK(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655879|imex:IM-20536-96	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000903.2|refseq:NP_001305426.1|refseq:NP_001269833.1|ensembl:ENSG00000082556(gene)|ensembl:ENST00000265572(transcript)|ensembl:ENST00000520287(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0033685"(negative regulation of luteinizing hormone secretion)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038048"(dynorphin receptor activity)|go:"GO:0040017"(positive regulation of locomotion)|go:"GO:0042277"(peptide binding)|go:"GO:0042711"(maternal behavior)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044849"(estrous cycle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046877"(regulation of saliva secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0050951"(sensory perception of temperature stimulus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1903937"(response to acrylamide)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:1990708"(conditioned place preference)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000452(Kappa opioid receptor)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2A0D|rcsb pdb:2IQN|rcsb pdb:4DJH|rcsb pdb:6B73|rcsb pdb:6VI4|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-9022699	-	-	-	figure legend:Table S2-85|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:UJUQfTpWND3otpIeautU4Nx0Ru49606	intact-crc:844D6EFAB5593837	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73358"	uniprotkb:P41145	intact:EBI-6655984	intact:EBI-925028|uniprotkb:Q499G4|uniprotkb:E5RHC9|ensembl:ENSP00000265572|ensembl:ENSP00000429706	psi-mi:u50488(display_short)|psi-mi:"CHEBI:73358"(display_long)	psi-mi:oprk_human(display_long)|uniprotkb:OPRK1(gene name)|psi-mi:OPRK1(display_short)|uniprotkb:OPRK(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655879|imex:IM-20536-96	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000903.2|refseq:NP_001305426.1|refseq:NP_001269833.1|ensembl:ENSG00000082556(gene)|ensembl:ENST00000265572(transcript)|ensembl:ENST00000520287(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0033685"(negative regulation of luteinizing hormone secretion)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038048"(dynorphin receptor activity)|go:"GO:0040017"(positive regulation of locomotion)|go:"GO:0042277"(peptide binding)|go:"GO:0042711"(maternal behavior)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044849"(estrous cycle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046877"(regulation of saliva secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0050951"(sensory perception of temperature stimulus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1903937"(response to acrylamide)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:1990708"(conditioned place preference)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000452(Kappa opioid receptor)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2A0D|rcsb pdb:2IQN|rcsb pdb:4DJH|rcsb pdb:6B73|rcsb pdb:6VI4|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-9022699	-	-	-	figure legend:Table S2-85|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:UJUQfTpWND3otpIeautU4Nx0Ru49606	intact-crc:844D6EFAB5593837	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73337"	uniprotkb:Q9Y5N1	intact:EBI-6655140	intact:EBI-6626124|ensembl:ENSP00000342560|uniprotkb:Q4QRI7|uniprotkb:Q9GZX2|uniprotkb:Q9H4K8	psi-mi:"(r)α-me-histamine"(display_short)|psi-mi:"CHEBI:73337"(display_long)	psi-mi:hrh3_human(display_long)|uniprotkb:HRH3(gene name)|psi-mi:HRH3(display_short)|uniprotkb:GPCR97(gene name synonym)|uniprotkb:G-protein coupled receptor 97(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6626061|imex:IM-20536-84	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0045202"(synapse)|go:"GO:0050890"(cognition)|go:"GO:0098793"(presynapse)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003980(Histamine H3 receptor)|ensembl:ENSG00000101180(gene)|ensembl:ENST00000340177(transcript)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390650|go:"GO:0004969"(histamine receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|refseq:NP_009163.2|refseq:XP_005260323.1|dip:DIP-61456N	-	-	-	figure legend:Table S2-59|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.6x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:SXyMPoRgJlcfEl9djDo6Qw2yctE9606	intact-crc:937C3D2CE3CAF5F7	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73337"	uniprotkb:Q9Y5N1	intact:EBI-6655140	intact:EBI-6626124|ensembl:ENSP00000342560|uniprotkb:Q4QRI7|uniprotkb:Q9GZX2|uniprotkb:Q9H4K8	psi-mi:"(r)α-me-histamine"(display_short)|psi-mi:"CHEBI:73337"(display_long)	psi-mi:hrh3_human(display_long)|uniprotkb:HRH3(gene name)|psi-mi:HRH3(display_short)|uniprotkb:GPCR97(gene name synonym)|uniprotkb:G-protein coupled receptor 97(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6626061|imex:IM-20536-84	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0045202"(synapse)|go:"GO:0050890"(cognition)|go:"GO:0098793"(presynapse)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003980(Histamine H3 receptor)|ensembl:ENSG00000101180(gene)|ensembl:ENST00000340177(transcript)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390650|go:"GO:0004969"(histamine receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|refseq:NP_009163.2|refseq:XP_005260323.1|dip:DIP-61456N	-	-	-	figure legend:Table S2-59|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.6x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:SXyMPoRgJlcfEl9djDo6Qw2yctE9606	intact-crc:937C3D2CE3CAF5F7	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:41879"	uniprotkb:P04150	intact:EBI-6656710	intact:EBI-493507|uniprotkb:P04151|uniprotkb:Q53EP5|uniprotkb:Q6N0A4|uniprotkb:B0LPG8|uniprotkb:D3DQF4|uniprotkb:A0ZXF9|uniprotkb:F5ATB7|ensembl:ENSP00000343205|ensembl:ENSP00000377977|ensembl:ENSP00000427672	psi-mi:dexamethasone(display_short)|psi-mi:"CHEBI:41879"(display_long)	psi-mi:gcr_human(display_long)|uniprotkb:Nuclear receptor subfamily 3 group C member 1(gene name synonym)|uniprotkb:NR3C1(gene name)|psi-mi:NR3C1(display_short)|uniprotkb:GRL(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656684|imex:IM-20536-115	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000167.1|refseq:NP_001018084.1|refseq:NP_001018085.1|refseq:NP_001018086.1|refseq:NP_001018087.1|refseq:NP_001018661.1|refseq:NP_001019265.1|refseq:NP_001191187.1|refseq:NP_001191188.1|refseq:NP_001191189.1|refseq:NP_001191190.1|refseq:NP_001191191.1|refseq:NP_001191192.1|refseq:NP_001191193.1|refseq:XP_005268476.1|refseq:XP_005268477.1|refseq:XP_005268479.1|refseq:XP_005268480.1|ensembl:ENSG00000113580(gene)|ensembl:ENST00000343796(transcript)|ensembl:ENST00000394464(transcript)|ensembl:ENST00000503201(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0004883"(glucocorticoid receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007165"(signal transduction)|rcsb pdb:5E69|rcsb pdb:5E6A|rcsb pdb:5E6B|go:"GO:0008270"(zinc ion binding)|go:"GO:0016607"(nuclear speck)|rcsb pdb:5E6C|rcsb pdb:5E6D|go:"GO:0019901"(protein kinase binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990239"(steroid hormone binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001409(Glucocorticoid receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P04150|rcsb pdb:1M2Z|rcsb pdb:1NHZ|rcsb pdb:1P93|rcsb pdb:3BQD|rcsb pdb:3CLD|rcsb pdb:3E7C|rcsb pdb:3H52|rcsb pdb:3K22|rcsb pdb:3K23|rcsb pdb:4CSJ|rcsb pdb:4HN5|rcsb pdb:4HN6|rcsb pdb:4LSJ|rcsb pdb:4MDD|rcsb pdb:4P6W|rcsb pdb:4P6X|rcsb pdb:4UDC|rcsb pdb:4UDD|rcsb pdb:5CBX|rcsb pdb:5CBY|rcsb pdb:5CBZ|rcsb pdb:5CC1|refseq:XP_016864886.1|refseq:XP_016864887.1|rcsb pdb:5EMC|rcsb pdb:5EMP|rcsb pdb:5EMQ|rcsb pdb:5G3J|rcsb pdb:5G5W|rcsb pdb:5NFP|rcsb pdb:5NFT|rcsb pdb:5UC3|rcsb pdb:5VA0|rcsb pdb:5VA7|rcsb pdb:6BQU|rcsb pdb:6CFN|rcsb pdb:6DXK|rcsb pdb:6EL6|rcsb pdb:6EL7|rcsb pdb:6EL9|rcsb pdb:6X6D|rcsb pdb:6X6E|rcsb pdb:6YMO|rcsb pdb:6YO8|rcsb pdb:6YOS|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-400253|reactome:R-HSA-4090294|reactome:R-HSA-8849473|reactome:R-HSA-8939902|reactome:R-HSA-9615017|reactome:R-HSA-9679191|dip:DIP-576N	-	-	-	figure legend:Table S2-106|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:4.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:4IOUe8VfG++O0M9uS6phAd8TBzw9606	intact-crc:20BE3A121B0166FE	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:9667"	uniprotkb:P04150	intact:EBI-6656705	intact:EBI-493507|uniprotkb:P04151|uniprotkb:Q53EP5|uniprotkb:Q6N0A4|uniprotkb:B0LPG8|uniprotkb:D3DQF4|uniprotkb:A0ZXF9|uniprotkb:F5ATB7|ensembl:ENSP00000343205|ensembl:ENSP00000377977|ensembl:ENSP00000427672	psi-mi:triamcinolone(display_short)|psi-mi:"CHEBI:9667"(display_long)	psi-mi:gcr_human(display_long)|uniprotkb:Nuclear receptor subfamily 3 group C member 1(gene name synonym)|uniprotkb:NR3C1(gene name)|psi-mi:NR3C1(display_short)|uniprotkb:GRL(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656684|imex:IM-20536-115	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000167.1|refseq:NP_001018084.1|refseq:NP_001018085.1|refseq:NP_001018086.1|refseq:NP_001018087.1|refseq:NP_001018661.1|refseq:NP_001019265.1|refseq:NP_001191187.1|refseq:NP_001191188.1|refseq:NP_001191189.1|refseq:NP_001191190.1|refseq:NP_001191191.1|refseq:NP_001191192.1|refseq:NP_001191193.1|refseq:XP_005268476.1|refseq:XP_005268477.1|refseq:XP_005268479.1|refseq:XP_005268480.1|ensembl:ENSG00000113580(gene)|ensembl:ENST00000343796(transcript)|ensembl:ENST00000394464(transcript)|ensembl:ENST00000503201(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0004883"(glucocorticoid receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007165"(signal transduction)|rcsb pdb:5E69|rcsb pdb:5E6A|rcsb pdb:5E6B|go:"GO:0008270"(zinc ion binding)|go:"GO:0016607"(nuclear speck)|rcsb pdb:5E6C|rcsb pdb:5E6D|go:"GO:0019901"(protein kinase binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990239"(steroid hormone binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001409(Glucocorticoid receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P04150|rcsb pdb:1M2Z|rcsb pdb:1NHZ|rcsb pdb:1P93|rcsb pdb:3BQD|rcsb pdb:3CLD|rcsb pdb:3E7C|rcsb pdb:3H52|rcsb pdb:3K22|rcsb pdb:3K23|rcsb pdb:4CSJ|rcsb pdb:4HN5|rcsb pdb:4HN6|rcsb pdb:4LSJ|rcsb pdb:4MDD|rcsb pdb:4P6W|rcsb pdb:4P6X|rcsb pdb:4UDC|rcsb pdb:4UDD|rcsb pdb:5CBX|rcsb pdb:5CBY|rcsb pdb:5CBZ|rcsb pdb:5CC1|refseq:XP_016864886.1|refseq:XP_016864887.1|rcsb pdb:5EMC|rcsb pdb:5EMP|rcsb pdb:5EMQ|rcsb pdb:5G3J|rcsb pdb:5G5W|rcsb pdb:5NFP|rcsb pdb:5NFT|rcsb pdb:5UC3|rcsb pdb:5VA0|rcsb pdb:5VA7|rcsb pdb:6BQU|rcsb pdb:6CFN|rcsb pdb:6DXK|rcsb pdb:6EL6|rcsb pdb:6EL7|rcsb pdb:6EL9|rcsb pdb:6X6D|rcsb pdb:6X6E|rcsb pdb:6YMO|rcsb pdb:6YO8|rcsb pdb:6YOS|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-400253|reactome:R-HSA-4090294|reactome:R-HSA-8849473|reactome:R-HSA-8939902|reactome:R-HSA-9615017|reactome:R-HSA-9679191|dip:DIP-576N	-	-	-	figure legend:Table S2-106|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:4.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:4IOUe8VfG++O0M9uS6phAd8TBzw9606	intact-crc:20BE3A121B0166FE	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:15843"	uniprotkb:P23219	intact:EBI-6662097	intact:EBI-6655935|ensembl:ENSP00000354612|uniprotkb:B4DHQ2|uniprotkb:A8K1V7|uniprotkb:Q15122|uniprotkb:Q5T7T6|uniprotkb:Q5T7T7|uniprotkb:Q5T7T8|uniprotkb:B4E2S5|uniprotkb:Q3HY28|uniprotkb:Q3HY29	psi-mi:arachidonic acid(display_short)|psi-mi:"CHEBI:15843"(display_long)	psi-mi:pgh1_human(display_long)|uniprotkb:PTGS1(gene name)|psi-mi:PTGS1(display_short)|uniprotkb:COX1(gene name synonym)|uniprotkb:Cyclooxygenase-1(gene name synonym)|uniprotkb:Prostaglandin H2 synthase 1(gene name synonym)|uniprotkb:Prostaglandin-endoperoxide synthase 1(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662089|imex:IM-20536-128	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000095303(gene)|ensembl:ENST00000362012(transcript)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004666"(prostaglandin-endoperoxide synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0020037"(heme binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR010255(Haem peroxidase)|interpro:IPR019791|interpro:IPR029580|interpro:IPR037120|rcsb pdb:6Y3C|reactome:R-HSA-2162123|reactome:R-HSA-140180|refseq:XP_011517178.1|refseq:NP_000953.2|refseq:NP_001258094.1|refseq:NP_542158.1|refseq:NP_001258095.1|refseq:NP_001258297.1	-	-	-	figure legend:Table S2-126|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.01x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:XNeWMly5H6EmY+3hq5bbAjBK4c09606	intact-crc:24B87A14A3198B05	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:47381"	uniprotkb:P23219	intact:EBI-6662099	intact:EBI-6655935|ensembl:ENSP00000354612|uniprotkb:B4DHQ2|uniprotkb:A8K1V7|uniprotkb:Q15122|uniprotkb:Q5T7T6|uniprotkb:Q5T7T7|uniprotkb:Q5T7T8|uniprotkb:B4E2S5|uniprotkb:Q3HY28|uniprotkb:Q3HY29	psi-mi:diclofenac(display_short)|psi-mi:"CHEBI:47381"(display_long)	psi-mi:pgh1_human(display_long)|uniprotkb:PTGS1(gene name)|psi-mi:PTGS1(display_short)|uniprotkb:COX1(gene name synonym)|uniprotkb:Cyclooxygenase-1(gene name synonym)|uniprotkb:Prostaglandin H2 synthase 1(gene name synonym)|uniprotkb:Prostaglandin-endoperoxide synthase 1(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662089|imex:IM-20536-128	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000095303(gene)|ensembl:ENST00000362012(transcript)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004666"(prostaglandin-endoperoxide synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0020037"(heme binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR010255(Haem peroxidase)|interpro:IPR019791|interpro:IPR029580|interpro:IPR037120|rcsb pdb:6Y3C|reactome:R-HSA-2162123|reactome:R-HSA-140180|refseq:XP_011517178.1|refseq:NP_000953.2|refseq:NP_001258094.1|refseq:NP_542158.1|refseq:NP_001258095.1|refseq:NP_001258297.1	-	-	-	figure legend:Table S2-126|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.01x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:XNeWMly5H6EmY+3hq5bbAjBK4c09606	intact-crc:24B87A14A3198B05	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73282"	uniprotkb:P30542	intact:EBI-6622582	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	psi-mi:dpcpx(display_short)|psi-mi:"CHEBI:73282"(display_long)	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622587|imex:IM-20536-57	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	-	-	-	figure legend:Table S2-2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:12.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	intact-crc:D23B46F9584B0689	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73282"	uniprotkb:P30542	intact:EBI-6622582	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	psi-mi:dpcpx(display_short)|psi-mi:"CHEBI:73282"(display_long)	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622587|imex:IM-20536-57	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	-	-	-	figure legend:Table S2-2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:12.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	intact-crc:D23B46F9584B0689	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:2904"	uniprotkb:P08588	intact:EBI-6622774	intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4	psi-mi:atenolol(display_short)|psi-mi:"CHEBI:2904"(display_long)	psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622768|imex:IM-20536-65	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N	-	-	-	figure legend:Table S2-10|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.61x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606	intact-crc:8A18E78626B63E08	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73288"	uniprotkb:P08588	intact:EBI-6622766	intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4	psi-mi:cgp 12177(display_short)|psi-mi:"CHEBI:73288"(display_long)	psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622768|imex:IM-20536-65	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N	-	-	-	figure legend:Table S2-10|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.61x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606	intact-crc:8A18E78626B63E08	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73287"	uniprotkb:P08913	intact:EBI-6622747	intact:EBI-6622671|ensembl:ENSP00000280155|uniprotkb:B0LPF6|uniprotkb:Q2I8G2|uniprotkb:Q2XN99|uniprotkb:Q86TH8|uniprotkb:Q9BZK1	psi-mi:rx-821002(display_short)|psi-mi:"CHEBI:73287"(display_long)	psi-mi:ada2a_human(display_long)|uniprotkb:ADRA2A(gene name)|psi-mi:ADRA2A(display_short)|uniprotkb:ADRA2R(gene name synonym)|uniprotkb:ADRAR(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C10(gene name synonym)|uniprotkb:Alpha-2A adrenoreceptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622749|imex:IM-20536-63	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000150594(gene)|ensembl:ENST00000280155(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031696"(alpha-2C adrenergic receptor binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042596"(fear response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071881"(adenylate cyclase-inhibiting adrenergic receptor signaling pathway)|go:"GO:0071882"(phospholipase C-activating adrenergic receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001946(Adrenergic receptor, alpha-2A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1HLL|rcsb pdb:1HO9|rcsb pdb:1HOD|rcsb pdb:1HOF|rcsb pdb:6K42|rcsb pdb:6KUX|rcsb pdb:6KUY|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000672.3|dip:DIP-61452N	-	-	-	figure legend:Table S2-8|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:6.7x10^-9(molar)	2013/04/23	2020/01/08	-	rogid:U+fZeOEBa5ofBs8XfKYhxPYeNhY9606	intact-crc:8CBF9D9301D3400A	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:10093"	uniprotkb:P08913	intact:EBI-6622755	intact:EBI-6622671|ensembl:ENSP00000280155|uniprotkb:B0LPF6|uniprotkb:Q2I8G2|uniprotkb:Q2XN99|uniprotkb:Q86TH8|uniprotkb:Q9BZK1	psi-mi:yohimbine(display_short)|psi-mi:"CHEBI:10093"(display_long)	psi-mi:ada2a_human(display_long)|uniprotkb:ADRA2A(gene name)|psi-mi:ADRA2A(display_short)|uniprotkb:ADRA2R(gene name synonym)|uniprotkb:ADRAR(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C10(gene name synonym)|uniprotkb:Alpha-2A adrenoreceptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622749|imex:IM-20536-63	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000150594(gene)|ensembl:ENST00000280155(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031696"(alpha-2C adrenergic receptor binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042596"(fear response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071881"(adenylate cyclase-inhibiting adrenergic receptor signaling pathway)|go:"GO:0071882"(phospholipase C-activating adrenergic receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001946(Adrenergic receptor, alpha-2A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1HLL|rcsb pdb:1HO9|rcsb pdb:1HOD|rcsb pdb:1HOF|rcsb pdb:6K42|rcsb pdb:6KUX|rcsb pdb:6KUY|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000672.3|dip:DIP-61452N	-	-	-	figure legend:Table S2-8|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:6.7x10^-9(molar)	2013/04/23	2020/01/08	-	rogid:U+fZeOEBa5ofBs8XfKYhxPYeNhY9606	intact-crc:8CBF9D9301D3400A	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73475"	uniprotkb:P22303	intact:EBI-6662740	intact:EBI-1637793|uniprotkb:Q16169|uniprotkb:Q86TM9|uniprotkb:Q9BXP7|uniprotkb:A4D2E2|uniprotkb:Q29S23|uniprotkb:Q2M324|uniprotkb:Q504V3|uniprotkb:Q86YX9|uniprotkb:D6W5X7|uniprotkb:B7ZKZ0|uniprotkb:Q53F46|ensembl:ENSP00000394976|ensembl:ENSP00000414858|ensembl:ENSP00000241069	psi-mi:acetyl-beta-methyl-thiocholine(display_short)|psi-mi:"CHEBI:73475"(display_long)	psi-mi:aces_human(display_long)|uniprotkb:ACHE(gene name)|psi-mi:ACHE(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662763|imex:IM-20536-142	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011514530.1|refseq:XP_011514531.1|refseq:NP_000656.1|refseq:NP_056646.1|ensembl:ENSG00000087085|refseq:XP_006716058.1|refseq:NP_001289550.1|refseq:NP_001289551.1|refseq:NP_001269378.1|dip:DIP-1119N|ensembl:ENSG00000087085(gene)|ensembl:ENST00000241069(transcript)|ensembl:ENST00000412389(transcript)|ensembl:ENST00000428317(transcript)|go:"GO:0001507"(acetylcholine catabolic process in synaptic cleft)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0002076"(osteoblast development)|go:"GO:0003990"(acetylcholinesterase activity)|go:"GO:0004104"(cholinesterase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006581"(acetylcholine catabolic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0017171"(serine hydrolase activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032223"(negative regulation of synaptic transmission, cholinergic)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043236"(laminin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000997(Cholinesterase)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR014788(Acetylcholinesterase, tetramerisation)|interpro:IPR019819|interpro:IPR019826|interpro:IPR029058|rcsb pdb:1B41|rcsb pdb:1F8U|rcsb pdb:1PUV|rcsb pdb:1PUW|rcsb pdb:1VZJ|rcsb pdb:2CLJ|rcsb pdb:2X8B|rcsb pdb:3LII|rcsb pdb:4BDT|rcsb pdb:4EY4|rcsb pdb:4EY5|rcsb pdb:4EY6|rcsb pdb:4EY7|rcsb pdb:4EY8|rcsb pdb:4M0E|rcsb pdb:4M0F|rcsb pdb:4PQE|rcsb pdb:5FOQ|rcsb pdb:5FPQ|rcsb pdb:5HF5|rcsb pdb:5HF6|rcsb pdb:5HF8|rcsb pdb:5HF9|rcsb pdb:5HFA|rcsb pdb:6CQT|rcsb pdb:6CQU|rcsb pdb:6CQV|rcsb pdb:6CQW|rcsb pdb:6CQX|rcsb pdb:6CQY|rcsb pdb:6CQZ|rcsb pdb:6F25|rcsb pdb:6NEA|rcsb pdb:6NTG|rcsb pdb:6NTH|rcsb pdb:6NTK|rcsb pdb:6NTL|rcsb pdb:6NTM|rcsb pdb:6NTN|rcsb pdb:6NTO|rcsb pdb:6O4W|rcsb pdb:6O4X|rcsb pdb:6O50|rcsb pdb:6O52|rcsb pdb:6O5R|rcsb pdb:6O5S|rcsb pdb:6O5V|rcsb pdb:6O66|rcsb pdb:6O69|rcsb pdb:6U34|rcsb pdb:6U37|rcsb pdb:6U3P|rcsb pdb:6WUV|rcsb pdb:6WUY|rcsb pdb:6WUZ|rcsb pdb:6WV1|rcsb pdb:6WVC|rcsb pdb:6WVO|rcsb pdb:6WVP|rcsb pdb:6WVQ|rcsb pdb:6ZWE|reactome:R-HSA-112311|reactome:R-HSA-1483191|reactome:R-HSA-422085	-	-	-	figure legend:Table S2-139|caution:"The authors have confirmed that the substrate  described as \"acetyl-6-methylthiocholine\", is really acetyl-(beta-methyl)thiocholine, and that  the iodide salt was used (CHEBI:73545)."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:7JpI1FosTcbuldkkW4tg62j1piE9606	intact-crc:78A4BF765E41E779	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P32239	uniprotkb:P06307-PRO_0000010542	intact:EBI-1753137|uniprotkb:A8K7P9|uniprotkb:O75824|uniprotkb:Q16144|uniprotkb:Q92492|uniprotkb:Q96LC6|uniprotkb:Q9NYK7|uniprotkb:Q9UBV1|ensembl:ENSP00000335544	intact:EBI-6624436	psi-mi:gasr_human(display_long)|uniprotkb:CCKBR(gene name)|psi-mi:CCKBR(display_short)|uniprotkb:CCKRB(gene name synonym)|uniprotkb:Cholecystokinin-2 receptor(gene name synonym)	psi-mi:p06307-pro_0000010542(display_long)|uniprotkb:CCK(gene name)|psi-mi:CCK(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624389|imex:IM-20536-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_795344.1|refseq:XP_005253267.1|refseq:NP_001304958.1|refseq:XP_016874005.1|dip:DIP-229N|go:"GO:0031741"(type B gastrin/cholecystokinin receptor binding)|go:"GO:0038188"(cholecystokinin signaling pathway)|go:"GO:0045851"(pH reduction)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0048565"(digestive tract development)|go:"GO:0048732"(gland development)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000314(Gastrin receptor)|interpro:IPR009126(Cholecystokinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P32239|rcsb pdb:1L4T|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-881907|go:"GO:0017046"(peptide hormone binding)|ensembl:ENSG00000110148(gene)|ensembl:ENST00000334619(transcript)|go:"GO:0001696"(gastric acid secretion)|go:"GO:0004951"(cholecystokinin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015054"(gastrin receptor activity)|go:"GO:0016021"(integral component of membrane)	intact:EBI-6624398(chain-parent)	-	-	chain-seq-start:96|chain-seq-end:103	figure legend:Table S2-31|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.49(molar)	2013/04/23	2014/10/16	rogid:wmvdbFzpde5hkgKlLrXxAJdZd8s9606	rogid:4lN3IKpzLMShDTVjTiIj/NfwYmE9606	intact-crc:B2EBC67E3CE6466D|rigid:4ZMKQacLjilTv7RZvmRLEHv26SY	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P32239	uniprotkb:P06307-PRO_0000010542	intact:EBI-1753137|uniprotkb:A8K7P9|uniprotkb:O75824|uniprotkb:Q16144|uniprotkb:Q92492|uniprotkb:Q96LC6|uniprotkb:Q9NYK7|uniprotkb:Q9UBV1|ensembl:ENSP00000335544	intact:EBI-6624436	psi-mi:gasr_human(display_long)|uniprotkb:CCKBR(gene name)|psi-mi:CCKBR(display_short)|uniprotkb:CCKRB(gene name synonym)|uniprotkb:Cholecystokinin-2 receptor(gene name synonym)	psi-mi:p06307-pro_0000010542(display_long)|uniprotkb:CCK(gene name)|psi-mi:CCK(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624389|imex:IM-20536-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_795344.1|refseq:XP_005253267.1|refseq:NP_001304958.1|refseq:XP_016874005.1|dip:DIP-229N|go:"GO:0031741"(type B gastrin/cholecystokinin receptor binding)|go:"GO:0038188"(cholecystokinin signaling pathway)|go:"GO:0045851"(pH reduction)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0048565"(digestive tract development)|go:"GO:0048732"(gland development)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000314(Gastrin receptor)|interpro:IPR009126(Cholecystokinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P32239|rcsb pdb:1L4T|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-881907|go:"GO:0017046"(peptide hormone binding)|ensembl:ENSG00000110148(gene)|ensembl:ENST00000334619(transcript)|go:"GO:0001696"(gastric acid secretion)|go:"GO:0004951"(cholecystokinin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015054"(gastrin receptor activity)|go:"GO:0016021"(integral component of membrane)	intact:EBI-6624398(chain-parent)	-	-	chain-seq-start:96|chain-seq-end:103	figure legend:Table S2-31|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.49(molar)	2013/04/23	2014/10/16	rogid:wmvdbFzpde5hkgKlLrXxAJdZd8s9606	rogid:4lN3IKpzLMShDTVjTiIj/NfwYmE9606	intact-crc:B2EBC67E3CE6466D|rigid:4ZMKQacLjilTv7RZvmRLEHv26SY	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73380"	uniprotkb:Q13639	intact:EBI-6656483	intact:EBI-6656425|ensembl:ENSP00000367120|ensembl:ENSP00000485747|uniprotkb:Q546Q1|uniprotkb:Q684M0|uniprotkb:Q712M9|uniprotkb:Q96KH9|uniprotkb:Q96KI0|uniprotkb:Q9H199|uniprotkb:Q9NY73|uniprotkb:Q9UBM6|uniprotkb:Q9UBT4|uniprotkb:Q9UE22|uniprotkb:Q9UE23|uniprotkb:Q9UQR6|uniprotkb:C4WYH4	psi-mi:gr 113808(display_short)|psi-mi:"CHEBI:73380"(display_long)	psi-mi:5ht4r_human(display_long)|uniprotkb:HTR4(gene name)|psi-mi:HTR4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656410|imex:IM-20536-107	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001273339.1|ensembl:ENSG00000164270(gene)|ensembl:ENST00000377888(transcript)|ensembl:ENST00000631296(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q13639|rcsb pdb:5EM9|reactome:R-HSA-390666|reactome:R-HSA-418555|reactome:R-HSA-9660821|refseq:NP_000861.1|refseq:NP_001035259.1|refseq:NP_001035262.2|refseq:NP_001035263.1|refseq:NP_955525.1	-	-	-	figure legend:Table S2-99|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:130.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:5+1AMJ2Bq46D7PZcb+0pVHgBY/U9606	intact-crc:4AF5B80B6ED64A06	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28790"	uniprotkb:Q13639	intact:EBI-6656313	intact:EBI-6656425|ensembl:ENSP00000367120|ensembl:ENSP00000485747|uniprotkb:Q546Q1|uniprotkb:Q684M0|uniprotkb:Q712M9|uniprotkb:Q96KH9|uniprotkb:Q96KI0|uniprotkb:Q9H199|uniprotkb:Q9NY73|uniprotkb:Q9UBM6|uniprotkb:Q9UBT4|uniprotkb:Q9UE22|uniprotkb:Q9UE23|uniprotkb:Q9UQR6|uniprotkb:C4WYH4	psi-mi:serotonin(display_short)|psi-mi:"CHEBI:28790"(display_long)	psi-mi:5ht4r_human(display_long)|uniprotkb:HTR4(gene name)|psi-mi:HTR4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656410|imex:IM-20536-107	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001273339.1|ensembl:ENSG00000164270(gene)|ensembl:ENST00000377888(transcript)|ensembl:ENST00000631296(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q13639|rcsb pdb:5EM9|reactome:R-HSA-390666|reactome:R-HSA-418555|reactome:R-HSA-9660821|refseq:NP_000861.1|refseq:NP_001035259.1|refseq:NP_001035262.2|refseq:NP_001035263.1|refseq:NP_955525.1	-	-	-	figure legend:Table S2-99|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:130.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:5+1AMJ2Bq46D7PZcb+0pVHgBY/U9606	intact-crc:4AF5B80B6ED64A06	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:15843"	uniprotkb:P35354	intact:EBI-6662097	intact:EBI-6662113|ensembl:ENSP00000356438|ensembl:ENSP00000506242|uniprotkb:A8K802|uniprotkb:Q16876	psi-mi:arachidonic acid(display_short)|psi-mi:"CHEBI:15843"(display_long)	psi-mi:pgh2_human(display_long)|uniprotkb:PTGS2(gene name)|psi-mi:PTGS2(display_short)|uniprotkb:COX2(gene name synonym)|uniprotkb:Cyclooxygenase-2(gene name synonym)|uniprotkb:PHS II(gene name synonym)|uniprotkb:Prostaglandin H2 synthase 2(gene name synonym)|uniprotkb:Prostaglandin-endoperoxide synthase 2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662107|imex:IM-20536-130	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000073756(gene)|ensembl:ENST00000367468(transcript)|ensembl:ENST00000680451(transcript)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001525"(angiogenesis)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004666"(prostaglandin-endoperoxide synthase activity)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005901"(caveola)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007566"(embryo implantation)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0030728"(ovulation)|go:"GO:0007613"(memory)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042633"(hair cycle)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0009750"(response to fructose)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010042"(response to manganese ion)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0010226"(response to lithium ion)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046697"(decidualization)|go:"GO:0046872"(metal ion binding)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0090362"(positive regulation of platelet-derived growth factor production)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR010255(Haem peroxidase)|interpro:IPR019791|interpro:IPR029576|interpro:IPR037120|rcsb pdb:1V0X|rcsb pdb:5F19|rcsb pdb:5F1A|rcsb pdb:5IKQ|rcsb pdb:5IKR|go:"GO:0070542"(response to fatty acid)|rcsb pdb:5IKT|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071284"(cellular response to lead ion)|rcsb pdb:5IKV|go:"GO:0071318"(cellular response to ATP)|go:"GO:0071456"(cellular response to hypoxia)|rcsb pdb:5KIR|reactome:R-HSA-197264|reactome:R-HSA-2142770|go:"GO:0071471"(cellular response to non-ionic osmotic stress)|reactome:R-HSA-2162123|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9018677|reactome:R-HSA-9018679|reactome:R-HSA-9025094|reactome:R-HSA-9027604|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|refseq:NP_000954.1|dip:DIP-28131N	-	-	-	figure legend:Table S2-128|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:33.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:WGHtPKMIVOhbG4HdzQyqaBTUH509606	intact-crc:BAAED69E30527EF3	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73458"	uniprotkb:P35354	intact:EBI-6662196	intact:EBI-6662113|ensembl:ENSP00000356438|ensembl:ENSP00000506242|uniprotkb:A8K802|uniprotkb:Q16876	psi-mi:ns398(display_short)|psi-mi:"CHEBI:73458"(display_long)	psi-mi:pgh2_human(display_long)|uniprotkb:PTGS2(gene name)|psi-mi:PTGS2(display_short)|uniprotkb:COX2(gene name synonym)|uniprotkb:Cyclooxygenase-2(gene name synonym)|uniprotkb:PHS II(gene name synonym)|uniprotkb:Prostaglandin H2 synthase 2(gene name synonym)|uniprotkb:Prostaglandin-endoperoxide synthase 2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662107|imex:IM-20536-130	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000073756(gene)|ensembl:ENST00000367468(transcript)|ensembl:ENST00000680451(transcript)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001525"(angiogenesis)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004666"(prostaglandin-endoperoxide synthase activity)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005901"(caveola)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007566"(embryo implantation)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0030728"(ovulation)|go:"GO:0007613"(memory)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042633"(hair cycle)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0009750"(response to fructose)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010042"(response to manganese ion)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0010226"(response to lithium ion)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046697"(decidualization)|go:"GO:0046872"(metal ion binding)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0090362"(positive regulation of platelet-derived growth factor production)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR010255(Haem peroxidase)|interpro:IPR019791|interpro:IPR029576|interpro:IPR037120|rcsb pdb:1V0X|rcsb pdb:5F19|rcsb pdb:5F1A|rcsb pdb:5IKQ|rcsb pdb:5IKR|go:"GO:0070542"(response to fatty acid)|rcsb pdb:5IKT|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071284"(cellular response to lead ion)|rcsb pdb:5IKV|go:"GO:0071318"(cellular response to ATP)|go:"GO:0071456"(cellular response to hypoxia)|rcsb pdb:5KIR|reactome:R-HSA-197264|reactome:R-HSA-2142770|go:"GO:0071471"(cellular response to non-ionic osmotic stress)|reactome:R-HSA-2162123|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9018677|reactome:R-HSA-9018679|reactome:R-HSA-9025094|reactome:R-HSA-9027604|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|refseq:NP_000954.1|dip:DIP-28131N	-	-	-	figure legend:Table S2-128|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:33.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:WGHtPKMIVOhbG4HdzQyqaBTUH509606	intact-crc:BAAED69E30527EF3	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28790"	uniprotkb:P47898	intact:EBI-6656313	intact:EBI-6656588|ensembl:ENSP00000287907|uniprotkb:Q2M2D2	psi-mi:serotonin(display_short)|psi-mi:"CHEBI:28790"(display_long)	psi-mi:5ht5a_human(display_long)|uniprotkb:HTR5A(gene name)|psi-mi:HTR5A(display_short)|uniprotkb:Serotonin receptor 5A(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656499|imex:IM-20536-109	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|ensembl:ENSG00000157219(gene)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0021766"(hippocampus development)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0043204"(perikaryon)|go:"GO:0051378"(serotonin binding)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001397(5-Hydroxytryptamine 5A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390666|reactome:R-HSA-418594|ensembl:ENST00000287907(transcript)|refseq:NP_076917.1	-	-	-	figure legend:Table S2-101|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:101.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:DX9z1YvHoUG2SKUGvc8xsGYXVB09606	intact-crc:70F87526456EFE26	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:6605"	uniprotkb:P47898	intact:EBI-6656639	intact:EBI-6656588|ensembl:ENSP00000287907|uniprotkb:Q2M2D2	psi-mi:lsd-lysergic acid  diethylamide(display_short)|psi-mi:"CHEBI:6605"(display_long)	psi-mi:5ht5a_human(display_long)|uniprotkb:HTR5A(gene name)|psi-mi:HTR5A(display_short)|uniprotkb:Serotonin receptor 5A(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656499|imex:IM-20536-109	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|ensembl:ENSG00000157219(gene)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0021766"(hippocampus development)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0043204"(perikaryon)|go:"GO:0051378"(serotonin binding)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001397(5-Hydroxytryptamine 5A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390666|reactome:R-HSA-418594|ensembl:ENST00000287907(transcript)|refseq:NP_076917.1	-	-	-	figure legend:Table S2-101|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:101.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:DX9z1YvHoUG2SKUGvc8xsGYXVB09606	intact-crc:70F87526456EFE26	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P24394	uniprotkb:P05112	intact:EBI-367009|uniprotkb:Q96P01|uniprotkb:Q9H181|uniprotkb:Q9H182|uniprotkb:Q9H183|uniprotkb:Q9H184|uniprotkb:Q9H185|uniprotkb:Q9H186|uniprotkb:Q9H187|uniprotkb:Q9H188|uniprotkb:B4E076|uniprotkb:B9EKU8|uniprotkb:H3BSY5|ensembl:ENSP00000379111|ensembl:ENSP00000441667	intact:EBI-367025|uniprotkb:Q14630|uniprotkb:Q6NZ77|ensembl:ENSP00000231449	psi-mi:il4ra_human(display_long)|uniprotkb:IL4R(gene name)|psi-mi:IL4R(display_short)|uniprotkb:582J2.1(orf name)|uniprotkb:IL4RA(gene name synonym)	psi-mi:il4_human(display_long)|uniprotkb:IL4(gene name)|psi-mi:IL4(display_short)|uniprotkb:B-cell stimulatory factor 1(gene name synonym)|uniprotkb:Lymphocyte stimulatory factor 1(gene name synonym)|uniprotkb:Binetrakin(gene name synonym)|uniprotkb:Pitrakinra(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624912|imex:IM-20536-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001244336.1|refseq:NP_000409.1|refseq:XP_011544127.1|refseq:XP_011544128.1|refseq:XP_011544129.1|refseq:NP_001244335.1|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901741"(positive regulation of myoblast fusion)|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3BPO|go:"GO:1990834"(response to odorant)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015319(Interleukin-4 receptor alpha chain, N-terminal)|interpro:IPR036116|rcsb pdb:1IAR|rcsb pdb:5E4E|rcsb pdb:6OEL|rcsb pdb:1IRS|rcsb pdb:1ITE|rcsb pdb:6WGL|reactome:R-HSA-6785807|ensembl:ENSG00000077238(gene)|ensembl:ENST00000395762(transcript)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENST00000543915(transcript)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043627"(response to estrogen)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004913"(interleukin-4 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0030728"(ovulation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-3223N	refseq:NP_000580.1|refseq:NP_758858.1|ensembl:ENSG00000113520(gene)|ensembl:ENST00000231449(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005136"(interleukin-4 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031296"(B cell costimulation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042116"(macrophage activation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000424"(positive regulation of eosinophil chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR002354(Interleukin 4)|interpro:IPR009079(Four-helical cytokine-like, core)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|rcsb pdb:1BBN|rcsb pdb:1BCN|rcsb pdb:1CYL|rcsb pdb:1HIJ|rcsb pdb:1HIK|rcsb pdb:1HZI|rcsb pdb:1IAR|rcsb pdb:1ILL|rcsb pdb:1ITE|rcsb pdb:1ITI|rcsb pdb:1ITL|rcsb pdb:1ITM|rcsb pdb:1RCB|rcsb pdb:2B8U|rcsb pdb:2B8X|rcsb pdb:2B8Y|rcsb pdb:2B8Z|rcsb pdb:2B90|rcsb pdb:2B91|rcsb pdb:2CYK|rcsb pdb:2D48|rcsb pdb:2INT|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3QB7|rcsb pdb:4YDY|rcsb pdb:5FHX|rcsb pdb:6OEL|reactome:R-HSA-6785807|reactome:R-HSA-9012546|interpro:IPR018096|dip:DIP-3222N	-	-	-	figure legend:Table S2-47|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.1x10^-9(molar)	2013/04/23	2014/10/16	rogid:18E1cLQsvHGc0WRFqUzuGssLVg09606	rogid:Jmojsmx7uQfFInaExASOKFttPFk9606	intact-crc:B8891049D6B9DB85|rigid:DtvGhEVCBmLTfHPis5cgG5lD46Q	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P24394	uniprotkb:P05112	intact:EBI-367009|uniprotkb:Q96P01|uniprotkb:Q9H181|uniprotkb:Q9H182|uniprotkb:Q9H183|uniprotkb:Q9H184|uniprotkb:Q9H185|uniprotkb:Q9H186|uniprotkb:Q9H187|uniprotkb:Q9H188|uniprotkb:B4E076|uniprotkb:B9EKU8|uniprotkb:H3BSY5|ensembl:ENSP00000379111|ensembl:ENSP00000441667	intact:EBI-367025|uniprotkb:Q14630|uniprotkb:Q6NZ77|ensembl:ENSP00000231449	psi-mi:il4ra_human(display_long)|uniprotkb:IL4R(gene name)|psi-mi:IL4R(display_short)|uniprotkb:582J2.1(orf name)|uniprotkb:IL4RA(gene name synonym)	psi-mi:il4_human(display_long)|uniprotkb:IL4(gene name)|psi-mi:IL4(display_short)|uniprotkb:B-cell stimulatory factor 1(gene name synonym)|uniprotkb:Lymphocyte stimulatory factor 1(gene name synonym)|uniprotkb:Binetrakin(gene name synonym)|uniprotkb:Pitrakinra(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624912|imex:IM-20536-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001244336.1|refseq:NP_000409.1|refseq:XP_011544127.1|refseq:XP_011544128.1|refseq:XP_011544129.1|refseq:NP_001244335.1|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901741"(positive regulation of myoblast fusion)|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3BPO|go:"GO:1990834"(response to odorant)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015319(Interleukin-4 receptor alpha chain, N-terminal)|interpro:IPR036116|rcsb pdb:1IAR|rcsb pdb:5E4E|rcsb pdb:6OEL|rcsb pdb:1IRS|rcsb pdb:1ITE|rcsb pdb:6WGL|reactome:R-HSA-6785807|ensembl:ENSG00000077238(gene)|ensembl:ENST00000395762(transcript)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENST00000543915(transcript)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043627"(response to estrogen)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004913"(interleukin-4 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0030728"(ovulation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-3223N	refseq:NP_000580.1|refseq:NP_758858.1|ensembl:ENSG00000113520(gene)|ensembl:ENST00000231449(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005136"(interleukin-4 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031296"(B cell costimulation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042116"(macrophage activation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000424"(positive regulation of eosinophil chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR002354(Interleukin 4)|interpro:IPR009079(Four-helical cytokine-like, core)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|rcsb pdb:1BBN|rcsb pdb:1BCN|rcsb pdb:1CYL|rcsb pdb:1HIJ|rcsb pdb:1HIK|rcsb pdb:1HZI|rcsb pdb:1IAR|rcsb pdb:1ILL|rcsb pdb:1ITE|rcsb pdb:1ITI|rcsb pdb:1ITL|rcsb pdb:1ITM|rcsb pdb:1RCB|rcsb pdb:2B8U|rcsb pdb:2B8X|rcsb pdb:2B8Y|rcsb pdb:2B8Z|rcsb pdb:2B90|rcsb pdb:2B91|rcsb pdb:2CYK|rcsb pdb:2D48|rcsb pdb:2INT|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3QB7|rcsb pdb:4YDY|rcsb pdb:5FHX|rcsb pdb:6OEL|reactome:R-HSA-6785807|reactome:R-HSA-9012546|interpro:IPR018096|dip:DIP-3222N	-	-	-	figure legend:Table S2-47|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.1x10^-9(molar)	2013/04/23	2014/10/16	rogid:18E1cLQsvHGc0WRFqUzuGssLVg09606	rogid:Jmojsmx7uQfFInaExASOKFttPFk9606	intact-crc:B8891049D6B9DB85|rigid:DtvGhEVCBmLTfHPis5cgG5lD46Q	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25101	uniprotkb:P05305	intact:EBI-6624559|ensembl:ENSP00000315011|ensembl:ENSP00000498969|uniprotkb:B2R723|uniprotkb:B4E2V6|uniprotkb:B7Z9G6|uniprotkb:D3DP03|uniprotkb:E7ER36|uniprotkb:O43441|uniprotkb:Q16432|uniprotkb:Q16433|uniprotkb:Q8TBH2	intact:EBI-715181|uniprotkb:Q96DA1|ensembl:ENSP00000368683	psi-mi:ednra_human(display_long)|uniprotkb:Endothelin receptor type A(gene name synonym)|uniprotkb:EDNRA(gene name)|psi-mi:EDNRA(display_short)|uniprotkb:ETA(gene name synonym)|uniprotkb:ETRA(gene name synonym)	psi-mi:edn1_human(display_long)|uniprotkb:Preproendothelin-1(gene name synonym)|uniprotkb:EDN1(gene name)|psi-mi:EDN1(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624551|imex:IM-20536-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-416476|ensembl:ENSG00000151617(gene)|ensembl:ENST00000324300(transcript)|ensembl:ENST00000651419(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004962"(endothelin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0042310"(vasoconstriction)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0060322"(head development)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000499(Endothelin receptor)|interpro:IPR002175(Endothelin A receptor)|refseq:NP_001159527.1|refseq:NP_001243212.1|refseq:NP_001948.1|ensembl:ENSG00000151617|ensembl:ENSG00000151617|dip:DIP-48718N	refseq:NP_001161791.1|refseq:NP_001946.3|refseq:XP_016865820.1|refseq:XP_011512632.1|refseq:XP_011512633.1|go:"GO:0007507"(heart development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007589"(body fluid secretion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010193"(response to ozone)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014826"(vein smooth muscle contraction)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030133"(transport vesicle)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031583"(phospholipase D-activating G protein-coupled receptor signaling pathway)|go:"GO:0031707"(endothelin A receptor binding)|go:"GO:0031708"(endothelin B receptor binding)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0042310"(vasoconstriction)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0033574"(response to testosterone)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0034696"(response to prostaglandin F)|go:"GO:0035094"(response to nicotine)|go:"GO:0035690"|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042313"(protein kinase C deactivation)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042482"(positive regulation of odontogenesis)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043179"(rhythmic excitation)|go:"GO:0043200"(response to amino acid)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044321"(response to leptin)|go:"GO:0045178"(basal part of cell)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048016"(inositol phosphate-mediated signaling)|go:"GO:0048237"(rough endoplasmic reticulum lumen)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0060298"(positive regulation of sarcomere organization)|go:"GO:0060585"(positive regulation of prostaglandin-endoperoxide synthase activity)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0030072"(peptide hormone secretion)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071389"(cellular response to mineralocorticoid stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902074"(response to salt)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR001928(Endothelin-like toxin)|interpro:IPR019764|interpro:IPR020475|rcsb pdb:1EDN|rcsb pdb:1EDP|rcsb pdb:1T7H|rcsb pdb:1V6R|rcsb pdb:5GLH|rcsb pdb:6DK5|reactome:R-HSA-375276|reactome:R-HSA-416476|ensembl:ENSG00000078401(gene)|ensembl:ENST00000379375(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001821"(histamine secretion)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006885"(regulation of pH)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)	-	-	-	figure legend:Table S2-37|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.13x10^-9(molar)	2013/04/23	2014/10/16	rogid:EkDVowJcGlTEodsDmAUnD89C7zY9606	rogid:rQ9w4UJP9y2E/71at8Js4ZdXY/A9606	intact-crc:94F35D8D7A5CCD5E|rigid:2yk/t528xCC9c4QDW/usOBYpaC4	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25101	uniprotkb:P05305	intact:EBI-6624559|ensembl:ENSP00000315011|ensembl:ENSP00000498969|uniprotkb:B2R723|uniprotkb:B4E2V6|uniprotkb:B7Z9G6|uniprotkb:D3DP03|uniprotkb:E7ER36|uniprotkb:O43441|uniprotkb:Q16432|uniprotkb:Q16433|uniprotkb:Q8TBH2	intact:EBI-715181|uniprotkb:Q96DA1|ensembl:ENSP00000368683	psi-mi:ednra_human(display_long)|uniprotkb:Endothelin receptor type A(gene name synonym)|uniprotkb:EDNRA(gene name)|psi-mi:EDNRA(display_short)|uniprotkb:ETA(gene name synonym)|uniprotkb:ETRA(gene name synonym)	psi-mi:edn1_human(display_long)|uniprotkb:Preproendothelin-1(gene name synonym)|uniprotkb:EDN1(gene name)|psi-mi:EDN1(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624551|imex:IM-20536-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-416476|ensembl:ENSG00000151617(gene)|ensembl:ENST00000324300(transcript)|ensembl:ENST00000651419(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004962"(endothelin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0042310"(vasoconstriction)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0060322"(head development)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000499(Endothelin receptor)|interpro:IPR002175(Endothelin A receptor)|refseq:NP_001159527.1|refseq:NP_001243212.1|refseq:NP_001948.1|ensembl:ENSG00000151617|ensembl:ENSG00000151617|dip:DIP-48718N	refseq:NP_001161791.1|refseq:NP_001946.3|refseq:XP_016865820.1|refseq:XP_011512632.1|refseq:XP_011512633.1|go:"GO:0007507"(heart development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007589"(body fluid secretion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010193"(response to ozone)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014826"(vein smooth muscle contraction)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030133"(transport vesicle)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031583"(phospholipase D-activating G protein-coupled receptor signaling pathway)|go:"GO:0031707"(endothelin A receptor binding)|go:"GO:0031708"(endothelin B receptor binding)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0042310"(vasoconstriction)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0033574"(response to testosterone)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0034696"(response to prostaglandin F)|go:"GO:0035094"(response to nicotine)|go:"GO:0035690"|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042313"(protein kinase C deactivation)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042482"(positive regulation of odontogenesis)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043179"(rhythmic excitation)|go:"GO:0043200"(response to amino acid)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044321"(response to leptin)|go:"GO:0045178"(basal part of cell)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048016"(inositol phosphate-mediated signaling)|go:"GO:0048237"(rough endoplasmic reticulum lumen)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0060298"(positive regulation of sarcomere organization)|go:"GO:0060585"(positive regulation of prostaglandin-endoperoxide synthase activity)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0030072"(peptide hormone secretion)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071389"(cellular response to mineralocorticoid stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902074"(response to salt)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR001928(Endothelin-like toxin)|interpro:IPR019764|interpro:IPR020475|rcsb pdb:1EDN|rcsb pdb:1EDP|rcsb pdb:1T7H|rcsb pdb:1V6R|rcsb pdb:5GLH|rcsb pdb:6DK5|reactome:R-HSA-375276|reactome:R-HSA-416476|ensembl:ENSG00000078401(gene)|ensembl:ENST00000379375(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001821"(histamine secretion)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006885"(regulation of pH)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)	-	-	-	figure legend:Table S2-37|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.13x10^-9(molar)	2013/04/23	2014/10/16	rogid:EkDVowJcGlTEodsDmAUnD89C7zY9606	rogid:rQ9w4UJP9y2E/71at8Js4ZdXY/A9606	intact-crc:94F35D8D7A5CCD5E|rigid:2yk/t528xCC9c4QDW/usOBYpaC4	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73340"	uniprotkb:P08173	intact:EBI-6655199	intact:EBI-6655217|ensembl:ENSP00000409378|ensembl:ENSP00000507561|uniprotkb:B2RPP4|uniprotkb:Q0VD60|uniprotkb:Q4VBK7	psi-mi:4-damp(display_short)|psi-mi:"CHEBI:73340"(display_long)	psi-mi:acm4_human(display_long)|uniprotkb:CHRM4(gene name)|psi-mi:CHRM4(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655238|imex:IM-20536-93	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000180720(gene)|ensembl:ENST00000433765(transcript)|ensembl:ENST00000682254(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001432(Muscarinic acetylcholine receptor M4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|rcsb pdb:5DSG|rcsb pdb:6D9H|rcsb pdb:6KP6|reactome:R-HSA-390648|reactome:R-HSA-418594|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|refseq:NP_000732.2|dip:DIP-61455N	-	-	-	figure legend:Table S2-68|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:Vl9zYuPmhxVM2yGmmttbZYJNDHM9606	intact-crc:BB3CA872512CF754	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P00533	uniprotkb:P01133	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	intact:EBI-640857|uniprotkb:B4DRK7|uniprotkb:E9PBF0|uniprotkb:Q52LZ6|uniprotkb:E7EVD2|ensembl:ENSP00000265171	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:egf_human(display_long)|uniprotkb:EGF(gene name)|psi-mi:EGF(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624899|imex:IM-20536-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	refseq:NP_001171602.1|refseq:NP_001954.2|refseq:NP_001171601.1|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051048"(negative regulation of secretion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR016317(Pro-epidermal growth factor)|interpro:IPR018097|mint:P01133|rcsb pdb:1IVO|rcsb pdb:1JL9|rcsb pdb:1NQL|rcsb pdb:1P9J|rcsb pdb:2KV4|rcsb pdb:3NJP|reactome:R-HSA-114608|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|ensembl:ENSG00000138798(gene)|ensembl:ENST00000265171(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038029"(epidermal growth factor receptor signaling pathway via MAPK cascade)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|dip:DIP-5767N	-	-	-	figure legend:Table S2-46|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:3.1x10^-9(molar)	2013/04/23	2014/10/16	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	rogid:H2Ewl436sfCPTMfgz7YGsLKq4Nk9606	intact-crc:484126FD7D1F3E3B|rigid:I9zZdk3yLeMWgXcmgRr768x43OA	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P00533	uniprotkb:P01133	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	intact:EBI-640857|uniprotkb:B4DRK7|uniprotkb:E9PBF0|uniprotkb:Q52LZ6|uniprotkb:E7EVD2|ensembl:ENSP00000265171	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:egf_human(display_long)|uniprotkb:EGF(gene name)|psi-mi:EGF(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624899|imex:IM-20536-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	refseq:NP_001171602.1|refseq:NP_001954.2|refseq:NP_001171601.1|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051048"(negative regulation of secretion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR016317(Pro-epidermal growth factor)|interpro:IPR018097|mint:P01133|rcsb pdb:1IVO|rcsb pdb:1JL9|rcsb pdb:1NQL|rcsb pdb:1P9J|rcsb pdb:2KV4|rcsb pdb:3NJP|reactome:R-HSA-114608|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|ensembl:ENSG00000138798(gene)|ensembl:ENST00000265171(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038029"(epidermal growth factor receptor signaling pathway via MAPK cascade)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|dip:DIP-5767N	-	-	-	figure legend:Table S2-46|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:3.1x10^-9(molar)	2013/04/23	2014/10/16	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	rogid:H2Ewl436sfCPTMfgz7YGsLKq4Nk9606	intact-crc:484126FD7D1F3E3B|rigid:I9zZdk3yLeMWgXcmgRr768x43OA	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:9233"	uniprotkb:P14416	intact:EBI-6624539	intact:EBI-2928178|ensembl:ENSP00000354859|ensembl:ENSP00000442172|uniprotkb:Q9NZR3|uniprotkb:Q9UPA9	psi-mi:spiperone(display_short)|psi-mi:"CHEBI:9233"(display_long)	psi-mi:drd2_human(display_long)|uniprotkb:DRD2(gene name)|psi-mi:DRD2(display_short)|uniprotkb:Dopamine D2 receptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624543|imex:IM-20536-79	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000149295(gene)|ensembl:ENST00000362072(transcript)|ensembl:ENST00000542968(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007616"(long-term memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014854"(response to inactivity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031223"(auditory behavior)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034776"(response to histamine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035240"(dopamine binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042220"(response to cocaine)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0042756"(drinking behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0043204"(perikaryon)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0043473"(pigmentation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046717"(acid secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048678"(response to axon injury)|go:"GO:0048755"(branching morphogenesis of a nerve)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0060160"(negative regulation of dopamine receptor signaling pathway)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090325"(regulation of locomotion involved in locomotory behavior)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1990384"(hyaloid vascular plexus regression)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001922(Dopamine D2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P14416|rcsb pdb:1I15|rcsb pdb:5AER|rcsb pdb:6CM4|rcsb pdb:6LUQ|rcsb pdb:6VMS|rcsb pdb:7JVR|reactome:R-HSA-390651|go:"GO:0051823"(regulation of synapse structural plasticity)|refseq:NP_000786.1|refseq:NP_057658.2|refseq:XP_016872785.1|dip:DIP-5977N	-	-	-	figure legend:Table S2-36|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:S5beCpwOapTeUXcS45WlU5ApKEI9606	intact-crc:F03C85AC2C934B66	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P20366-PRO_0000033530	uniprotkb:P25103	intact:EBI-6655360	intact:EBI-6655287|ensembl:ENSP00000303522|uniprotkb:A8K150	psi-mi:p20366-pro_0000033530(display_long)|uniprotkb:TAC1(gene name)|psi-mi:TAC1(display_short)|uniprotkb:NKA(gene name synonym)|uniprotkb:NKNA(gene name synonym)|uniprotkb:TAC2(gene name synonym)|uniprotkb:PPT(gene name synonym)	psi-mi:nk1r_human(display_long)|uniprotkb:TACR1(gene name)|psi-mi:TACR1(display_short)|uniprotkb:NK1R(gene name synonym)|uniprotkb:TAC1R(gene name synonym)|uniprotkb:NK-1 receptor(gene name synonym)|uniprotkb:Tachykinin receptor 1(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655246|imex:IM-20536-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-717291(chain-parent)	ensembl:ENSG00000115353(gene)|ensembl:ENST00000305249(transcript)|go:"GO:0004995"(tachykinin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0009582"(detection of abiotic stimulus)|go:"GO:0016496"(substance P receptor activity)|go:"GO:0036126"(sperm flagellum)|go:"GO:0048265"(response to pain)|go:"GO:0061827"(sperm head)|go:"GO:0070472"(regulation of uterine smooth muscle contraction)|go:"GO:0097225"(sperm midpiece)|go:"GO:1902093"(positive regulation of flagellated sperm motility)|interpro:IPR000046(Neurokinin NK1 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001681(Neurokinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KS9|rcsb pdb:2KSA|rcsb pdb:2KSB|rcsb pdb:6E59|rcsb pdb:6HLL|rcsb pdb:6HLO|rcsb pdb:6HLP|reactome:R-HSA-380095|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|refseq:NP_001049.1|refseq:NP_056542.1	-	chain-seq-start:58|chain-seq-end:68	-	figure legend:Table S2-71|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:E0Lo0d8Bsk/3bp7oq6z18KxQdug9606	rogid:Wd5f857uk5oTq9cGzATuRdq6LvE9606	intact-crc:603BCAA0D5051D55|rigid:dpsdN3QH4nWOg75fh2mitgTO6C0	false	3h radiolabel:?-?|methylated glycine:9-9|L-methionine sulfone:11-11	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73284"	uniprotkb:P29274	intact:EBI-6622609	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	psi-mi:neca(display_short)|psi-mi:"CHEBI:73284"(display_long)	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622603|imex:IM-20536-59	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	-	-	-	figure legend:Table S2-4|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:40.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	intact-crc:17DF8BC171F25015	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73283"	uniprotkb:P29274	intact:EBI-6622601	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	psi-mi:cgs-21680(display_short)|psi-mi:"CHEBI:73283"(display_long)	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622603|imex:IM-20536-59	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	-	-	-	figure legend:Table S2-4|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:40.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	intact-crc:17DF8BC171F25015	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73338"	uniprotkb:P08172	intact:EBI-6655177	intact:EBI-2624832|uniprotkb:Q4VBK6|uniprotkb:Q9P1X9|ensembl:ENSP00000319984|ensembl:ENSP00000384401|ensembl:ENSP00000399745|ensembl:ENSP00000415386|ensembl:ENSP00000505686	psi-mi:af-dx 384(display_short)|psi-mi:"CHEBI:73338"(display_long)	psi-mi:acm2_human(display_long)|uniprotkb:CHRM2(gene name)|psi-mi:CHRM2(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655182|imex:IM-20536-89	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011514071.1|refseq:NP_000730.1|refseq:NP_001006627.1|refseq:NP_001006628.1|refseq:NP_001006629.1|refseq:NP_001006630.1|refseq:NP_001006631.1|refseq:NP_001006632.1|refseq:NP_001006633.1|ensembl:ENSG00000181072(gene)|ensembl:ENST00000320658(transcript)|ensembl:ENST00000401861(transcript)|ensembl:ENST00000445907(transcript)|ensembl:ENST00000453373(transcript)|ensembl:ENST00000680005(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009615"(response to virus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001065(Muscarinic acetylcholine receptor M2)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LUB|rcsb pdb:3UON|rcsb pdb:4MQS|rcsb pdb:4MQT|rcsb pdb:5YC8|rcsb pdb:5ZK3|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|rcsb pdb:5ZKB|rcsb pdb:5ZKC|rcsb pdb:6OIK|rcsb pdb:6U1N|reactome:R-HSA-390648|reactome:R-HSA-418594|reactome:R-HSA-8856825|reactome:R-HSA-8856828|rcsb pdb:5ZK8|dip:DIP-56282N	-	-	-	figure legend:Table S2-64|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:Rg7s3/iAh4+DTvkasK8G/BWc+yM9606	intact-crc:023B21954B0F9019	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25101	uniprotkb:P05305	intact:EBI-6624559|ensembl:ENSP00000315011|ensembl:ENSP00000498969|uniprotkb:B2R723|uniprotkb:B4E2V6|uniprotkb:B7Z9G6|uniprotkb:D3DP03|uniprotkb:E7ER36|uniprotkb:O43441|uniprotkb:Q16432|uniprotkb:Q16433|uniprotkb:Q8TBH2	intact:EBI-715181|uniprotkb:Q96DA1|ensembl:ENSP00000368683	psi-mi:ednra_human(display_long)|uniprotkb:Endothelin receptor type A(gene name synonym)|uniprotkb:EDNRA(gene name)|psi-mi:EDNRA(display_short)|uniprotkb:ETA(gene name synonym)|uniprotkb:ETRA(gene name synonym)	psi-mi:edn1_human(display_long)|uniprotkb:Preproendothelin-1(gene name synonym)|uniprotkb:EDN1(gene name)|psi-mi:EDN1(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624640|imex:IM-20536-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-416476|ensembl:ENSG00000151617(gene)|ensembl:ENST00000324300(transcript)|ensembl:ENST00000651419(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004962"(endothelin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0042310"(vasoconstriction)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0060322"(head development)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000499(Endothelin receptor)|interpro:IPR002175(Endothelin A receptor)|refseq:NP_001159527.1|refseq:NP_001243212.1|refseq:NP_001948.1|ensembl:ENSG00000151617|ensembl:ENSG00000151617|dip:DIP-48718N	refseq:NP_001161791.1|refseq:NP_001946.3|refseq:XP_016865820.1|refseq:XP_011512632.1|refseq:XP_011512633.1|go:"GO:0007507"(heart development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007589"(body fluid secretion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010193"(response to ozone)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014826"(vein smooth muscle contraction)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030133"(transport vesicle)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031583"(phospholipase D-activating G protein-coupled receptor signaling pathway)|go:"GO:0031707"(endothelin A receptor binding)|go:"GO:0031708"(endothelin B receptor binding)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0042310"(vasoconstriction)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0033574"(response to testosterone)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0034696"(response to prostaglandin F)|go:"GO:0035094"(response to nicotine)|go:"GO:0035690"|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042313"(protein kinase C deactivation)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042482"(positive regulation of odontogenesis)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043179"(rhythmic excitation)|go:"GO:0043200"(response to amino acid)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044321"(response to leptin)|go:"GO:0045178"(basal part of cell)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048016"(inositol phosphate-mediated signaling)|go:"GO:0048237"(rough endoplasmic reticulum lumen)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0060298"(positive regulation of sarcomere organization)|go:"GO:0060585"(positive regulation of prostaglandin-endoperoxide synthase activity)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0030072"(peptide hormone secretion)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071389"(cellular response to mineralocorticoid stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902074"(response to salt)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR001928(Endothelin-like toxin)|interpro:IPR019764|interpro:IPR020475|rcsb pdb:1EDN|rcsb pdb:1EDP|rcsb pdb:1T7H|rcsb pdb:1V6R|rcsb pdb:5GLH|rcsb pdb:6DK5|reactome:R-HSA-375276|reactome:R-HSA-416476|ensembl:ENSG00000078401(gene)|ensembl:ENST00000379375(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001821"(histamine secretion)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006885"(regulation of pH)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)	-	-	-	figure legend:Table S2-38|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:EkDVowJcGlTEodsDmAUnD89C7zY9606	rogid:rQ9w4UJP9y2E/71at8Js4ZdXY/A9606	intact-crc:F82662E1913A5F9E|rigid:2yk/t528xCC9c4QDW/usOBYpaC4	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:6605"	uniprotkb:P34969	intact:EBI-6656639	intact:EBI-2625020|uniprotkb:B5BUP6|uniprotkb:P78336|uniprotkb:P78372|uniprotkb:P78516|uniprotkb:Q5VX01|uniprotkb:Q5VX02|ensembl:ENSP00000337949|uniprotkb:Q5VX03	psi-mi:lsd-lysergic acid  diethylamide(display_short)|psi-mi:"CHEBI:6605"(display_long)	psi-mi:5ht7r_human(display_long)|uniprotkb:HTR7(gene name)|psi-mi:HTR7(display_short)|uniprotkb:5-HT-X(gene name synonym)|uniprotkb:Serotonin receptor 7(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656676|imex:IM-20536-114	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000863.1|refseq:NP_062873.1|refseq:NP_062874.1|ensembl:ENSG00000148680(gene)|ensembl:ENST00000336152(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008015"(blood circulation)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042310"(vasoconstriction)|go:"GO:0045202"(synapse)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001069(5-Hydroxytryptamine 7 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390666|reactome:R-HSA-418555|reactome:R-HSA-9660821|reactome:R-HSA-9706019	-	-	-	figure legend:Table S2-105|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:NoHrTf52SNxtQ9a9C5SaPy74CNU9606	intact-crc:6EBA79E5642480CA	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P41146	uniprotkb:Q13519-PRO_0000008327	intact:EBI-2624699|uniprotkb:Q8TD34|uniprotkb:Q8WYH9|uniprotkb:Q9H4K4|ensembl:ENSP00000336764|ensembl:ENSP00000336843|ensembl:ENSP00000347848	intact:EBI-6656256	psi-mi:oprx_human(display_long)|uniprotkb:OPRL1(gene name)|psi-mi:OPRL1(display_short)|uniprotkb:OOR(gene name synonym)|uniprotkb:ORL1(gene name synonym)|uniprotkb:Orphanin FQ receptor(gene name synonym)|uniprotkb:Kappa-type 3 opioid receptor(gene name synonym)	psi-mi:q13519-pro_0000008327(display_long)|uniprotkb:PNOC(gene name)|psi-mi:PNOC(display_short)|uniprotkb:OFQ(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656134|imex:IM-20536-48	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000904.1|refseq:NP_001186948.1|refseq:NP_872588.1|refseq:XP_016883343.1|refseq:XP_016883344.1|ensembl:ENSG00000125510(gene)|ensembl:ENST00000336866(transcript)|ensembl:ENST00000349451(transcript)|ensembl:ENST00000355631(transcript)|go:"GO:0001626"(nociceptin receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007600"(sensory perception)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060454"(positive regulation of gastric acid secretion)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:1990708"(conditioned place preference)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR001420(X opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P41146|rcsb pdb:4EA3|rcsb pdb:5DHG|rcsb pdb:5DHH|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_001305782.1|refseq:NP_001305783.1|refseq:NP_001305784.1	intact:EBI-6656238(chain-parent)	-	-	chain-seq-start:130|chain-seq-end:146	figure legend:Table S2-89|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:XB+gV8yHArDnVcaYZADiPZRgncE9606	rogid:QkWdfrsF2pxBB2+A69ZLyL7fgJA9606	intact-crc:AA68F9A5BAE71D72|rigid:IDIaYPEPApM3YRAdrjuzxZ3Wou0	false	-	3h radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P41146	uniprotkb:Q13519-PRO_0000008327	intact:EBI-2624699|uniprotkb:Q8TD34|uniprotkb:Q8WYH9|uniprotkb:Q9H4K4|ensembl:ENSP00000336764|ensembl:ENSP00000336843|ensembl:ENSP00000347848	intact:EBI-6656256	psi-mi:oprx_human(display_long)|uniprotkb:OPRL1(gene name)|psi-mi:OPRL1(display_short)|uniprotkb:OOR(gene name synonym)|uniprotkb:ORL1(gene name synonym)|uniprotkb:Orphanin FQ receptor(gene name synonym)|uniprotkb:Kappa-type 3 opioid receptor(gene name synonym)	psi-mi:q13519-pro_0000008327(display_long)|uniprotkb:PNOC(gene name)|psi-mi:PNOC(display_short)|uniprotkb:OFQ(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656134|imex:IM-20536-48	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000904.1|refseq:NP_001186948.1|refseq:NP_872588.1|refseq:XP_016883343.1|refseq:XP_016883344.1|ensembl:ENSG00000125510(gene)|ensembl:ENST00000336866(transcript)|ensembl:ENST00000349451(transcript)|ensembl:ENST00000355631(transcript)|go:"GO:0001626"(nociceptin receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007600"(sensory perception)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060454"(positive regulation of gastric acid secretion)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:1990708"(conditioned place preference)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR001420(X opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P41146|rcsb pdb:4EA3|rcsb pdb:5DHG|rcsb pdb:5DHH|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_001305782.1|refseq:NP_001305783.1|refseq:NP_001305784.1	intact:EBI-6656238(chain-parent)	-	-	chain-seq-start:130|chain-seq-end:146	figure legend:Table S2-89|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:XB+gV8yHArDnVcaYZADiPZRgncE9606	rogid:QkWdfrsF2pxBB2+A69ZLyL7fgJA9606	intact-crc:AA68F9A5BAE71D72|rigid:IDIaYPEPApM3YRAdrjuzxZ3Wou0	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28229"	uniprotkb:P35228	intact:EBI-6662311	intact:EBI-6662224|uniprotkb:A1L3U5|uniprotkb:B7ZLY2|uniprotkb:O60757|uniprotkb:O94994|uniprotkb:Q16263|uniprotkb:Q16692|uniprotkb:Q4TTS5|uniprotkb:Q9UD42|ensembl:ENSP00000327251	psi-mi:l-nmma(display_short)|psi-mi:"CHEBI:28229"(display_long)	psi-mi:nos2_human(display_long)|uniprotkb:NOS2(gene name)|psi-mi:NOS2(display_short)|uniprotkb:NOS2A(gene name synonym)|uniprotkb:Hepatocyte NOS(gene name synonym)|uniprotkb:Inducible NO synthase(gene name synonym)|uniprotkb:NOS type II(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662218|imex:IM-20536-134	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011523161.1|refseq:NP_000616.3|dip:DIP-59359N|ensembl:ENSG00000007171(gene)|ensembl:ENST00000313735(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001912"(positive regulation of leukocyte mediated cytotoxicity)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0020037"(heme binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0032310"(prostaglandin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0035690"|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|rcsb pdb:1NSI|rcsb pdb:2LL6|rcsb pdb:2NSI|rcsb pdb:3E7G|rcsb pdb:3EJ8|rcsb pdb:3HR4|rcsb pdb:4CX7|rcsb pdb:4NOS|rcsb pdb:5TP6|rcsb pdb:5XN3|rcsb pdb:6JWM|rcsb pdb:6JWN|rcsb pdb:6KEY|reactome:R-HSA-1222556|reactome:R-HSA-392154|reactome:R-HSA-6785807|reactome:R-HSA-9033241|reactome:R-HSA-9636249	-	-	-	figure legend:Table S2-132|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.8x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:T1W4KxGaDieo3kQ8OTZjNXA4iF49606	intact-crc:A87AFF24BDDE2CEA	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:16467"	uniprotkb:P35228	intact:EBI-6662307	intact:EBI-6662224|uniprotkb:A1L3U5|uniprotkb:B7ZLY2|uniprotkb:O60757|uniprotkb:O94994|uniprotkb:Q16263|uniprotkb:Q16692|uniprotkb:Q4TTS5|uniprotkb:Q9UD42|ensembl:ENSP00000327251	psi-mi:arginine(display_short)|psi-mi:"CHEBI:16467"(display_long)	psi-mi:nos2_human(display_long)|uniprotkb:NOS2(gene name)|psi-mi:NOS2(display_short)|uniprotkb:NOS2A(gene name synonym)|uniprotkb:Hepatocyte NOS(gene name synonym)|uniprotkb:Inducible NO synthase(gene name synonym)|uniprotkb:NOS type II(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662218|imex:IM-20536-134	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011523161.1|refseq:NP_000616.3|dip:DIP-59359N|ensembl:ENSG00000007171(gene)|ensembl:ENST00000313735(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001912"(positive regulation of leukocyte mediated cytotoxicity)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0020037"(heme binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0032310"(prostaglandin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0035690"|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|rcsb pdb:1NSI|rcsb pdb:2LL6|rcsb pdb:2NSI|rcsb pdb:3E7G|rcsb pdb:3EJ8|rcsb pdb:3HR4|rcsb pdb:4CX7|rcsb pdb:4NOS|rcsb pdb:5TP6|rcsb pdb:5XN3|rcsb pdb:6JWM|rcsb pdb:6JWN|rcsb pdb:6KEY|reactome:R-HSA-1222556|reactome:R-HSA-392154|reactome:R-HSA-6785807|reactome:R-HSA-9033241|reactome:R-HSA-9636249	-	-	-	figure legend:Table S2-132|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.8x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:T1W4KxGaDieo3kQ8OTZjNXA4iF49606	intact-crc:A87AFF24BDDE2CEA	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P00533	uniprotkb:P01133	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	intact:EBI-640857|uniprotkb:B4DRK7|uniprotkb:E9PBF0|uniprotkb:Q52LZ6|uniprotkb:E7EVD2|ensembl:ENSP00000265171	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:egf_human(display_long)|uniprotkb:EGF(gene name)|psi-mi:EGF(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624889|imex:IM-20536-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	refseq:NP_001171602.1|refseq:NP_001954.2|refseq:NP_001171601.1|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051048"(negative regulation of secretion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR016317(Pro-epidermal growth factor)|interpro:IPR018097|mint:P01133|rcsb pdb:1IVO|rcsb pdb:1JL9|rcsb pdb:1NQL|rcsb pdb:1P9J|rcsb pdb:2KV4|rcsb pdb:3NJP|reactome:R-HSA-114608|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|ensembl:ENSG00000138798(gene)|ensembl:ENST00000265171(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038029"(epidermal growth factor receptor signaling pathway via MAPK cascade)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|dip:DIP-5767N	-	-	-	figure legend:Table S2-45|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.13x10^-9(molar)	2013/04/23	2014/10/16	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	rogid:H2Ewl436sfCPTMfgz7YGsLKq4Nk9606	intact-crc:4843F6FD7D1F3E3B|rigid:I9zZdk3yLeMWgXcmgRr768x43OA	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P00533	uniprotkb:P01133	intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5	intact:EBI-640857|uniprotkb:B4DRK7|uniprotkb:E9PBF0|uniprotkb:Q52LZ6|uniprotkb:E7EVD2|ensembl:ENSP00000265171	psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym)	psi-mi:egf_human(display_long)|uniprotkb:EGF(gene name)|psi-mi:EGF(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624889|imex:IM-20536-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N	refseq:NP_001171602.1|refseq:NP_001954.2|refseq:NP_001171601.1|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051048"(negative regulation of secretion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR016317(Pro-epidermal growth factor)|interpro:IPR018097|mint:P01133|rcsb pdb:1IVO|rcsb pdb:1JL9|rcsb pdb:1NQL|rcsb pdb:1P9J|rcsb pdb:2KV4|rcsb pdb:3NJP|reactome:R-HSA-114608|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|ensembl:ENSG00000138798(gene)|ensembl:ENST00000265171(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0038029"(epidermal growth factor receptor signaling pathway via MAPK cascade)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|dip:DIP-5767N	-	-	-	figure legend:Table S2-45|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.13x10^-9(molar)	2013/04/23	2014/10/16	rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606	rogid:H2Ewl436sfCPTMfgz7YGsLKq4Nk9606	intact-crc:4843F6FD7D1F3E3B|rigid:I9zZdk3yLeMWgXcmgRr768x43OA	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73295"	uniprotkb:P21554	intact:EBI-6623451	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:win 55212-2(display_short)|psi-mi:"CHEBI:73295"(display_long)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623443|imex:IM-20536-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	-	-	-	figure legend:Table S2-25|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:19.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	intact-crc:1C0A7BE0DE67F732	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73295"	uniprotkb:P21554	intact:EBI-6623451	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:win 55212-2(display_short)|psi-mi:"CHEBI:73295"(display_long)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623443|imex:IM-20536-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	-	-	-	figure legend:Table S2-25|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:19.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	intact-crc:1C0A7BE0DE67F732	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q16602	uniprotkb:P06881	intact:EBI-962878|ensembl:ENSP00000376177|ensembl:ENSP00000386972|ensembl:ENSP00000387190|uniprotkb:A8KAD3|uniprotkb:A8K6G5|uniprotkb:Q53S02|uniprotkb:Q53TS5	intact:EBI-962928|ensembl:ENSP00000354286|ensembl:ENSP00000417833|uniprotkb:Q93048|uniprotkb:Q9UCP0	psi-mi:calrl_human(display_long)|uniprotkb:CALCRL(gene name)|psi-mi:CALCRL(display_short)|uniprotkb:CGRPR(gene name synonym)|uniprotkb:Calcitonin receptor-like receptor(gene name synonym)	psi-mi:calca_human(display_long)|uniprotkb:CALCA(gene name)|psi-mi:CALCA(display_short)|uniprotkb:CALC1(gene name synonym)|uniprotkb:Calcitonin gene-related peptide I(gene name synonym)|uniprotkb:Alpha-type CGRP(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623435|imex:IM-20536-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003287(GPCR, family 2, calcitonin receptor-like)|interpro:IPR003289(GPCR, family 2, calcitonin gene-related peptide, type 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:3AQF|rcsb pdb:3N7P|rcsb pdb:3N7R|rcsb pdb:3N7S|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:5V6Y|rcsb pdb:6D1U|rcsb pdb:6E3Y|rcsb pdb:6UMG|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6V2E|rcsb pdb:6ZHO|rcsb pdb:6ZIS|rcsb pdb:7KNT|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|ensembl:ENSG00000064989(gene)|ensembl:ENST00000392370(transcript)|ensembl:ENST00000409998(transcript)|ensembl:ENST00000410068(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004948"(calcitonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071329"(cellular response to sucrose stimulus)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:0005886"(plasma membrane)|refseq:NP_005786.1|refseq:NP_001258680.1|dip:DIP-37674N	ensembl:ENST00000361010(transcript)|ensembl:ENST00000486207(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001944"(vasculature development)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|ensembl:ENSG00000110680(gene)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0031623"(receptor internalization)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0042311"(vasodilation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|interpro:IPR001693(Calcitonin-like)|interpro:IPR015476(Calcitonin gene related peptide)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1LS7|rcsb pdb:6E3Y|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|refseq:NP_001029125.1	-	-	-	figure legend:Table S2-24|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.47x10^-9(molar)	2013/04/23	2018/09/18	rogid:CezdatTOyGz/AEKWvRS/lTOrl9A9606	rogid:gM1XX8NUOJKraSnqNoX6NO0oH8E9606	intact-crc:8EE954D65FA1CD3A|rigid:kjISyunlOARToAqMHuNth3kY+Ls	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q16602	uniprotkb:P06881	intact:EBI-962878|ensembl:ENSP00000376177|ensembl:ENSP00000386972|ensembl:ENSP00000387190|uniprotkb:A8KAD3|uniprotkb:A8K6G5|uniprotkb:Q53S02|uniprotkb:Q53TS5	intact:EBI-962928|ensembl:ENSP00000354286|ensembl:ENSP00000417833|uniprotkb:Q93048|uniprotkb:Q9UCP0	psi-mi:calrl_human(display_long)|uniprotkb:CALCRL(gene name)|psi-mi:CALCRL(display_short)|uniprotkb:CGRPR(gene name synonym)|uniprotkb:Calcitonin receptor-like receptor(gene name synonym)	psi-mi:calca_human(display_long)|uniprotkb:CALCA(gene name)|psi-mi:CALCA(display_short)|uniprotkb:CALC1(gene name synonym)|uniprotkb:Calcitonin gene-related peptide I(gene name synonym)|uniprotkb:Alpha-type CGRP(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623435|imex:IM-20536-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003287(GPCR, family 2, calcitonin receptor-like)|interpro:IPR003289(GPCR, family 2, calcitonin gene-related peptide, type 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:3AQF|rcsb pdb:3N7P|rcsb pdb:3N7R|rcsb pdb:3N7S|go:"GO:1990410"(adrenomedullin receptor signaling pathway)|rcsb pdb:4RWF|rcsb pdb:4RWG|rcsb pdb:5V6Y|rcsb pdb:6D1U|rcsb pdb:6E3Y|rcsb pdb:6UMG|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6V2E|rcsb pdb:6ZHO|rcsb pdb:6ZIS|rcsb pdb:7KNT|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|ensembl:ENSG00000064989(gene)|ensembl:ENST00000392370(transcript)|ensembl:ENST00000409998(transcript)|ensembl:ENST00000410068(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001605"(adrenomedullin receptor activity)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004948"(calcitonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031623"(receptor internalization)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071329"(cellular response to sucrose stimulus)|go:"GO:1903143"(adrenomedullin receptor complex)|go:"GO:1990406"(CGRP receptor complex)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|go:"GO:1990409"(adrenomedullin binding)|go:"GO:0005886"(plasma membrane)|refseq:NP_005786.1|refseq:NP_001258680.1|dip:DIP-37674N	ensembl:ENST00000361010(transcript)|ensembl:ENST00000486207(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001944"(vasculature development)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|ensembl:ENSG00000110680(gene)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0031623"(receptor internalization)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0042311"(vasodilation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1990408"(calcitonin gene-related peptide receptor signaling pathway)|interpro:IPR001693(Calcitonin-like)|interpro:IPR015476(Calcitonin gene related peptide)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1LS7|rcsb pdb:6E3Y|rcsb pdb:7KNU|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|refseq:NP_001029125.1	-	-	-	figure legend:Table S2-24|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.47x10^-9(molar)	2013/04/23	2018/09/18	rogid:CezdatTOyGz/AEKWvRS/lTOrl9A9606	rogid:gM1XX8NUOJKraSnqNoX6NO0oH8E9606	intact-crc:8EE954D65FA1CD3A|rigid:kjISyunlOARToAqMHuNth3kY+Ls	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73290"	uniprotkb:P30536	intact:EBI-6623202	intact:EBI-6623146|ensembl:ENSP00000328973|ensembl:ENSP00000338004|ensembl:ENSP00000379563|uniprotkb:Q53Y59|uniprotkb:Q6ICF9|uniprotkb:Q96TF6	psi-mi:pk-11195(display_short)|psi-mi:"CHEBI:73290"(display_long)	psi-mi:tspo_human(display_long)|uniprotkb:TSPO(gene name)|psi-mi:TSPO(display_short)|uniprotkb:BZRP(gene name synonym)|uniprotkb:MBR(gene name synonym)|uniprotkb:Mitochondrial benzodiazepine receptor(gene name synonym)|uniprotkb:PKBS(gene name synonym)|uniprotkb:Peripheral-type benzodiazepine receptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623204|imex:IM-20536-69	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000100300(gene)|ensembl:ENST00000329563(transcript)|ensembl:ENST00000337554(transcript)|ensembl:ENST00000396265(transcript)|go:"GO:0005497"(androgen binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006700"(C21-steroid hormone biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0007568"(aging)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008347"(glial cell migration)|go:"GO:0008503"(benzodiazepine receptor activity)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010266"(response to vitamin B1)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030325"(adrenal gland development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060242"(contact inhibition)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0032570"(response to progesterone)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903579"(negative regulation of ATP metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004307(TspO/MBR-related protein)|interpro:IPR030164|interpro:IPR038330|reactome:R-HSA-196108|go:"GO:0033574"(response to testosterone)|refseq:NP_000705.2|refseq:NP_001243459.1|refseq:NP_001243460.1	-	-	-	figure legend:Table S2-18|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:32.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:A8KFWbHly01w8pFFNMygS76hCdI9606	intact-crc:DB7C6A05F6EB604D	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73290"	uniprotkb:P30536	intact:EBI-6623202	intact:EBI-6623146|ensembl:ENSP00000328973|ensembl:ENSP00000338004|ensembl:ENSP00000379563|uniprotkb:Q53Y59|uniprotkb:Q6ICF9|uniprotkb:Q96TF6	psi-mi:pk-11195(display_short)|psi-mi:"CHEBI:73290"(display_long)	psi-mi:tspo_human(display_long)|uniprotkb:TSPO(gene name)|psi-mi:TSPO(display_short)|uniprotkb:BZRP(gene name synonym)|uniprotkb:MBR(gene name synonym)|uniprotkb:Mitochondrial benzodiazepine receptor(gene name synonym)|uniprotkb:PKBS(gene name synonym)|uniprotkb:Peripheral-type benzodiazepine receptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623204|imex:IM-20536-69	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000100300(gene)|ensembl:ENST00000329563(transcript)|ensembl:ENST00000337554(transcript)|ensembl:ENST00000396265(transcript)|go:"GO:0005497"(androgen binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006700"(C21-steroid hormone biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0007568"(aging)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008347"(glial cell migration)|go:"GO:0008503"(benzodiazepine receptor activity)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010266"(response to vitamin B1)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030325"(adrenal gland development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060242"(contact inhibition)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0032570"(response to progesterone)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903579"(negative regulation of ATP metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004307(TspO/MBR-related protein)|interpro:IPR030164|interpro:IPR038330|reactome:R-HSA-196108|go:"GO:0033574"(response to testosterone)|refseq:NP_000705.2|refseq:NP_001243459.1|refseq:NP_001243460.1	-	-	-	figure legend:Table S2-18|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:32.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:A8KFWbHly01w8pFFNMygS76hCdI9606	intact-crc:DB7C6A05F6EB604D	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P30556	uniprotkb:P01019-PRO_0000032458	intact:EBI-6623016|uniprotkb:Q8TBK4|ensembl:ENSP00000273430|ensembl:ENSP00000385612|ensembl:ENSP00000418084|ensembl:ENSP00000418851|ensembl:ENSP00000419422|ensembl:ENSP00000419783|ensembl:ENSP00000385641|ensembl:ENSP00000398832|uniprotkb:Q13725	intact:EBI-6622938	psi-mi:agtr1_human(display_long)|uniprotkb:AGTR1(gene name)|psi-mi:AGTR1(display_short)|uniprotkb:AGTR1A(gene name synonym)|uniprotkb:AGTR1B(gene name synonym)|uniprotkb:AT2R1(gene name synonym)|uniprotkb:AT2R1B(gene name synonym)|uniprotkb:AT1AR(gene name synonym)|uniprotkb:AT1BR(gene name synonym)|uniprotkb:Angiotensin II type-1 receptor(gene name synonym)	psi-mi:p01019-pro_0000032458(display_long)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)|uniprotkb:Serpin A8(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623072|imex:IM-20536-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114038.4|refseq:NP_114438.2|ensembl:ENSG00000144891(gene)|ensembl:ENST00000349243(transcript)|ensembl:ENST00000402260(transcript)|ensembl:ENST00000404754(transcript)|ensembl:ENST00000461609(transcript)|ensembl:ENST00000474935(transcript)|ensembl:ENST00000475347(transcript)|ensembl:ENST00000497524(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001822"(kidney development)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|ensembl:ENST00000418473(transcript)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30556|rcsb pdb:1ZV0|rcsb pdb:4YAY|rcsb pdb:4ZUD|rcsb pdb:6DO1|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0019229"(regulation of vasoconstriction)|refseq:NP_004826.5|refseq:NP_000676.1|refseq:NP_033611.1	intact:EBI-751728(chain-parent)	-	-	chain-seq-start:34|chain-seq-end:41	figure legend:Table S2-14|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.2x10^-9(molar)	2013/04/23	2014/10/16	rogid:hrgCoboCmBvuoZEj5YuPnL+KuEQ9606	rogid:hq8n3YTVT4kiQ6W0wa89kcCJUQY9606	intact-crc:96210074C6D79F2F|rigid:n9JySQZliuwm8Vk4HUpO/1a2R3I	false	-	mutation:8-8|mutation:1-1|125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P30556	uniprotkb:P01017-PRO_0000032443	intact:EBI-6623016|uniprotkb:Q8TBK4|ensembl:ENSP00000273430|ensembl:ENSP00000385612|ensembl:ENSP00000418084|ensembl:ENSP00000418851|ensembl:ENSP00000419422|ensembl:ENSP00000419783|ensembl:ENSP00000385641|ensembl:ENSP00000398832|uniprotkb:Q13725	intact:EBI-6623100	psi-mi:agtr1_human(display_long)|uniprotkb:AGTR1(gene name)|psi-mi:AGTR1(display_short)|uniprotkb:AGTR1A(gene name synonym)|uniprotkb:AGTR1B(gene name synonym)|uniprotkb:AT2R1(gene name synonym)|uniprotkb:AT2R1B(gene name synonym)|uniprotkb:AT1AR(gene name synonym)|uniprotkb:AT1BR(gene name synonym)|uniprotkb:Angiotensin II type-1 receptor(gene name synonym)	psi-mi:p01017-pro_0000032443(display_long)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)|uniprotkb:Serpin A8(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623072|imex:IM-20536-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114038.4|refseq:NP_114438.2|ensembl:ENSG00000144891(gene)|ensembl:ENST00000349243(transcript)|ensembl:ENST00000402260(transcript)|ensembl:ENST00000404754(transcript)|ensembl:ENST00000461609(transcript)|ensembl:ENST00000474935(transcript)|ensembl:ENST00000475347(transcript)|ensembl:ENST00000497524(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001822"(kidney development)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|ensembl:ENST00000418473(transcript)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30556|rcsb pdb:1ZV0|rcsb pdb:4YAY|rcsb pdb:4ZUD|rcsb pdb:6DO1|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0019229"(regulation of vasoconstriction)|refseq:NP_004826.5|refseq:NP_000676.1|refseq:NP_033611.1	intact:EBI-6623088(chain-parent)	-	-	chain-seq-start:25|chain-seq-end:32	figure legend:Table S2-14|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.2x10^-9(molar)	2013/04/23	2014/10/16	rogid:hrgCoboCmBvuoZEj5YuPnL+KuEQ9606	rogid:Y7v3gjqD+W7BUKBXqJK3NeZ/JNY9913	intact-crc:96210074C6D79F2F|rigid:n9JySQZliuwm8Vk4HUpO/1a2R3I	false	-	mutation:1-1|mutation:8-8	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73289"	uniprotkb:P07550	intact:EBI-6622791	intact:EBI-491169|uniprotkb:Q9UH95|uniprotkb:Q9UHA1|uniprotkb:O14823|uniprotkb:O14824|uniprotkb:O14825|uniprotkb:O14826|uniprotkb:Q4JG18|uniprotkb:Q8NEQ9|uniprotkb:Q9UMZ5|uniprotkb:Q6P4D8|uniprotkb:B0LPE4|uniprotkb:B2R7X2|uniprotkb:Q53GA6|uniprotkb:Q6GMT4|uniprotkb:Q96EC3|uniprotkb:Q9UCZ0|uniprotkb:Q9UCZ1|uniprotkb:Q9UCZ2|uniprotkb:Q9UCZ3|ensembl:ENSP00000305372	psi-mi:ici 118551(display_short)|psi-mi:"CHEBI:73289"(display_long)	psi-mi:adrb2_human(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:ADRB2(gene name)|psi-mi:ADRB2(display_short)|uniprotkb:ADRB2R(gene name synonym)|uniprotkb:B2AR(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622784|imex:IM-20536-67	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000015.1|ensembl:ENSG00000169252(gene)|ensembl:ENST00000305988(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009409"(response to cold)|go:"GO:0010008"(endosome membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031649"(heat generation)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P07550|rcsb pdb:1GQ4|rcsb pdb:2R4R|rcsb pdb:2R4S|rcsb pdb:2RH1|rcsb pdb:3D4S|rcsb pdb:3KJ6|rcsb pdb:3NY8|rcsb pdb:3NY9|rcsb pdb:3NYA|rcsb pdb:3P0G|rcsb pdb:3PDS|rcsb pdb:3SN6|rcsb pdb:4GBR|rcsb pdb:4LDE|rcsb pdb:4LDL|rcsb pdb:4LDO|rcsb pdb:4QKX|rcsb pdb:5D5A|rcsb pdb:5D5B|rcsb pdb:5D6L|rcsb pdb:5JQH|rcsb pdb:5X7D|rcsb pdb:6E67|rcsb pdb:6KR8|rcsb pdb:6MXT|rcsb pdb:6N48|rcsb pdb:6NI3|rcsb pdb:6OBA|rcsb pdb:6PRZ|rcsb pdb:6PS0|rcsb pdb:6PS1|rcsb pdb:6PS2|rcsb pdb:6PS3|rcsb pdb:6PS4|rcsb pdb:6PS5|rcsb pdb:6PS6|rcsb pdb:7BZ2|rcsb pdb:7DHI|rcsb pdb:7DHR|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-5689880|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9660821|dip:DIP-33948N	-	-	-	figure legend:Table S2-12|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.9x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:+pZmEUm9SKroeqpa7uI44Bz18zo9606	intact-crc:46471C573A55D6FD	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73288"	uniprotkb:P07550	intact:EBI-6622766	intact:EBI-491169|uniprotkb:Q9UH95|uniprotkb:Q9UHA1|uniprotkb:O14823|uniprotkb:O14824|uniprotkb:O14825|uniprotkb:O14826|uniprotkb:Q4JG18|uniprotkb:Q8NEQ9|uniprotkb:Q9UMZ5|uniprotkb:Q6P4D8|uniprotkb:B0LPE4|uniprotkb:B2R7X2|uniprotkb:Q53GA6|uniprotkb:Q6GMT4|uniprotkb:Q96EC3|uniprotkb:Q9UCZ0|uniprotkb:Q9UCZ1|uniprotkb:Q9UCZ2|uniprotkb:Q9UCZ3|ensembl:ENSP00000305372	psi-mi:cgp 12177(display_short)|psi-mi:"CHEBI:73288"(display_long)	psi-mi:adrb2_human(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:ADRB2(gene name)|psi-mi:ADRB2(display_short)|uniprotkb:ADRB2R(gene name synonym)|uniprotkb:B2AR(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622784|imex:IM-20536-67	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000015.1|ensembl:ENSG00000169252(gene)|ensembl:ENST00000305988(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009409"(response to cold)|go:"GO:0010008"(endosome membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031649"(heat generation)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P07550|rcsb pdb:1GQ4|rcsb pdb:2R4R|rcsb pdb:2R4S|rcsb pdb:2RH1|rcsb pdb:3D4S|rcsb pdb:3KJ6|rcsb pdb:3NY8|rcsb pdb:3NY9|rcsb pdb:3NYA|rcsb pdb:3P0G|rcsb pdb:3PDS|rcsb pdb:3SN6|rcsb pdb:4GBR|rcsb pdb:4LDE|rcsb pdb:4LDL|rcsb pdb:4LDO|rcsb pdb:4QKX|rcsb pdb:5D5A|rcsb pdb:5D5B|rcsb pdb:5D6L|rcsb pdb:5JQH|rcsb pdb:5X7D|rcsb pdb:6E67|rcsb pdb:6KR8|rcsb pdb:6MXT|rcsb pdb:6N48|rcsb pdb:6NI3|rcsb pdb:6OBA|rcsb pdb:6PRZ|rcsb pdb:6PS0|rcsb pdb:6PS1|rcsb pdb:6PS2|rcsb pdb:6PS3|rcsb pdb:6PS4|rcsb pdb:6PS5|rcsb pdb:6PS6|rcsb pdb:7BZ2|rcsb pdb:7DHI|rcsb pdb:7DHR|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-5689880|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9660821|dip:DIP-33948N	-	-	-	figure legend:Table S2-12|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.9x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:+pZmEUm9SKroeqpa7uI44Bz18zo9606	intact-crc:46471C573A55D6FD	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73303"	uniprotkb:P25021	intact:EBI-6625245	intact:EBI-6625213|ensembl:ENSP00000231683|uniprotkb:B5BUP7|uniprotkb:Q14464|uniprotkb:Q7Z5R9	psi-mi:aminopotentidine(display_short)|psi-mi:"CHEBI:73303"(display_long)	psi-mi:hrh2_human(display_long)|uniprotkb:HRH2(gene name)|psi-mi:HRH2(display_short)|uniprotkb:Gastric receptor I(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6625197|imex:IM-20536-81	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000113749(gene)|go:"GO:0001696"(gastric acid secretion)|go:"GO:0004969"(histamine receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|ensembl:ENST00000231683(transcript)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000503(Histamine H2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390650|reactome:R-HSA-418555|reactome:R-HSA-9660821|refseq:NP_001124527.1|refseq:NP_071640.1	-	-	-	figure legend:Table S2-57|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:781.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:YT7Yjq76DeARz0+/Ffkz+WPnsdw9606	intact-crc:BC5DED112A693D8D	false	125i radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:3699"	uniprotkb:P25021	intact:EBI-6625692	intact:EBI-6625213|ensembl:ENSP00000231683|uniprotkb:B5BUP7|uniprotkb:Q14464|uniprotkb:Q7Z5R9	psi-mi:cimetidine(display_short)|psi-mi:"CHEBI:3699"(display_long)	psi-mi:hrh2_human(display_long)|uniprotkb:HRH2(gene name)|psi-mi:HRH2(display_short)|uniprotkb:Gastric receptor I(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6625197|imex:IM-20536-81	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000113749(gene)|go:"GO:0001696"(gastric acid secretion)|go:"GO:0004969"(histamine receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|ensembl:ENST00000231683(transcript)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000503(Histamine H2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390650|reactome:R-HSA-418555|reactome:R-HSA-9660821|refseq:NP_001124527.1|refseq:NP_071640.1	-	-	-	figure legend:Table S2-57|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:781.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:YT7Yjq76DeARz0+/Ffkz+WPnsdw9606	intact-crc:BC5DED112A693D8D	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73288"	uniprotkb:P07550	intact:EBI-6622766	intact:EBI-491169|uniprotkb:Q9UH95|uniprotkb:Q9UHA1|uniprotkb:O14823|uniprotkb:O14824|uniprotkb:O14825|uniprotkb:O14826|uniprotkb:Q4JG18|uniprotkb:Q8NEQ9|uniprotkb:Q9UMZ5|uniprotkb:Q6P4D8|uniprotkb:B0LPE4|uniprotkb:B2R7X2|uniprotkb:Q53GA6|uniprotkb:Q6GMT4|uniprotkb:Q96EC3|uniprotkb:Q9UCZ0|uniprotkb:Q9UCZ1|uniprotkb:Q9UCZ2|uniprotkb:Q9UCZ3|ensembl:ENSP00000305372	psi-mi:cgp 12177(display_short)|psi-mi:"CHEBI:73288"(display_long)	psi-mi:adrb2_human(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:ADRB2(gene name)|psi-mi:ADRB2(display_short)|uniprotkb:ADRB2R(gene name synonym)|uniprotkb:B2AR(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622778|imex:IM-20536-66	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000015.1|ensembl:ENSG00000169252(gene)|ensembl:ENST00000305988(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009409"(response to cold)|go:"GO:0010008"(endosome membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031649"(heat generation)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P07550|rcsb pdb:1GQ4|rcsb pdb:2R4R|rcsb pdb:2R4S|rcsb pdb:2RH1|rcsb pdb:3D4S|rcsb pdb:3KJ6|rcsb pdb:3NY8|rcsb pdb:3NY9|rcsb pdb:3NYA|rcsb pdb:3P0G|rcsb pdb:3PDS|rcsb pdb:3SN6|rcsb pdb:4GBR|rcsb pdb:4LDE|rcsb pdb:4LDL|rcsb pdb:4LDO|rcsb pdb:4QKX|rcsb pdb:5D5A|rcsb pdb:5D5B|rcsb pdb:5D6L|rcsb pdb:5JQH|rcsb pdb:5X7D|rcsb pdb:6E67|rcsb pdb:6KR8|rcsb pdb:6MXT|rcsb pdb:6N48|rcsb pdb:6NI3|rcsb pdb:6OBA|rcsb pdb:6PRZ|rcsb pdb:6PS0|rcsb pdb:6PS1|rcsb pdb:6PS2|rcsb pdb:6PS3|rcsb pdb:6PS4|rcsb pdb:6PS5|rcsb pdb:6PS6|rcsb pdb:7BZ2|rcsb pdb:7DHI|rcsb pdb:7DHR|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-5689880|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9660821|dip:DIP-33948N	-	-	-	figure legend:Table S2-11|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:+pZmEUm9SKroeqpa7uI44Bz18zo9606	intact-crc:40C53211C3AB3615	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P50052	uniprotkb:P01019-PRO_0000032459	intact:EBI-1748067|uniprotkb:Q13016|uniprotkb:Q6FGY7|uniprotkb:B2R9V1|ensembl:ENSP00000360973|ensembl:ENSP00000505750	intact:EBI-2927577	psi-mi:agtr2_human(display_long)|uniprotkb:AGTR2(gene name)|psi-mi:AGTR2(display_short)|uniprotkb:Angiotensin II type-2 receptor(gene name synonym)	psi-mi:p01019-pro_0000032459(display_long)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)|uniprotkb:Serpin A8(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623127|imex:IM-20536-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000677.2|refseq:XP_011535835.1|ensembl:ENSG00000180772(gene)|ensembl:ENST00000371906(transcript)|ensembl:ENST00000681852(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0001991"(regulation of systemic arterial blood pressure by circulatory renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032304"(negative regulation of icosanoid secretion)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0035932"(aldosterone secretion)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000147(AT2 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5UNF|rcsb pdb:5UNG|rcsb pdb:5UNH|rcsb pdb:6JOD|reactome:R-HSA-375276|reactome:R-HSA-418594	intact:EBI-751728(chain-parent)	-	-	chain-seq-start:35|chain-seq-end:41	figure legend:Table S2-15|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:tXWI4w7l3DHAfmhthRZY9Hxrvus9606	rogid:bFZEQAk7GJqer1R8daO4K+hXwPQ9606	intact-crc:6ED6CD0B1D5DFA0E|rigid:qty5vqPuhNQ3cm+H4X24hbPS0o0	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O43603	uniprotkb:P22466-PRO_0000010449	intact:EBI-6624855|ensembl:ENSP00000329684|uniprotkb:A5JUU4|uniprotkb:Q32MN8	intact:EBI-6624800	psi-mi:galr2_human(display_long)|uniprotkb:GALR2(gene name)|psi-mi:GALR2(display_short)|uniprotkb:GALNR2(gene name synonym)	psi-mi:p22466-pro_0000010449(display_long)|uniprotkb:GAL(gene name)|psi-mi:GAL(display_short)|uniprotkb:GAL1(gene name synonym)|uniprotkb:GALN(gene name synonym)|uniprotkb:GLNN(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624881|imex:IM-20536-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000182687(gene)|ensembl:ENST00000329003(transcript)|go:"GO:0004966"(galanin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007611"(learning or memory)|go:"GO:0005929"(cilium)|go:"GO:0007631"(feeding behavior)|go:"GO:0006936"(muscle contraction)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0090663"(galanin-activated signaling pathway)|go:"GO:1902608"(positive regulation of large conductance calcium-activated potassium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000405(Galanin receptor)|go:"GO:0007218"(neuropeptide signaling pathway)|interpro:IPR003907(Galanin 2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_003848.1	intact:EBI-6624768(chain-parent)	-	-	chain-seq-start:33|chain-seq-end:62	figure legend:Table S2-44|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:oOMJXr3SMk2TzwRk4CHvuTPCpeQ9606	rogid:Ap3LftulUqpof4tpDP+DuCa2Kiw9606	intact-crc:E6ABCB18AF6F70B3|rigid:g1/md0o3eNvSexKe+HqMw9vqtU0	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P37288	uniprotkb:P01282-PRO_0000011460	intact:EBI-6656842|ensembl:ENSP00000299178	intact:EBI-6656819	psi-mi:v1ar_human(display_long)|uniprotkb:AVPR1A(gene name)|psi-mi:AVPR1A(display_short)|uniprotkb:AVPR1(gene name synonym)|uniprotkb:AVPR V1a(gene name synonym)|uniprotkb:Antidiuretic hormone receptor 1a(gene name synonym)|uniprotkb:Vascular/hepatic-type arginine vasopressin receptor(gene name synonym)	psi-mi:p01282-pro_0000011460(display_long)|uniprotkb:VIP(gene name)|psi-mi:VIP(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656904|imex:IM-20536-53	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166148(gene)|ensembl:ENST00000299178(transcript)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0002125"(maternal aggressive behavior)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007621"(negative regulation of female receptivity)|go:"GO:0007625"(grooming behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021537"(telencephalon development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031894"(V1A vasopressin receptor binding)|go:"GO:0032849"(positive regulation of cellular pH reduction)|go:"GO:0035176"(social behavior)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042277"(peptide binding)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0043084"(penile erection)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051970"(negative regulation of transmission of nerve impulse)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001224(Vasopressin V1A receptor)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR015076(Region of unknown function DUF1856)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1YTV|reactome:R-HSA-388479|reactome:R-HSA-416476|reactome:R-HSA-5619099|refseq:NP_000697.1	intact:EBI-751454(chain-parent)	-	-	chain-seq-start:125|chain-seq-end:152	figure legend:Table S2-117|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:5abwd21TO9yfkHn1yTWTQlFE1489606	rogid:Ig8+sQ7x2wnattJ+N1G6SY+8xYA9606	intact-crc:50AF031CB87015FD|rigid:I2hYQxLikBjeUZ2oKHauf37iaTI	false	-	3h radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:7936"	uniprotkb:P31645	intact:EBI-6661758	intact:EBI-6116107|uniprotkb:Q5EE02|ensembl:ENSP00000261707|ensembl:ENSP00000385822|ensembl:ENSP00000498537	psi-mi:paroxetine(display_short)|psi-mi:"CHEBI:7936"(display_long)	psi-mi:sc6a4_human(display_long)|uniprotkb:SLC6A4(gene name)|psi-mi:SLC6A4(display_short)|uniprotkb:HTT(gene name synonym)|uniprotkb:SERT(gene name synonym)|uniprotkb:5HT transporter(gene name synonym)|uniprotkb:Solute carrier family 6 member 4(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6661763|imex:IM-20536-127	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001036.1|ensembl:ENSG00000108576(gene)|ensembl:ENST00000261707(transcript)|ensembl:ENST00000401766(transcript)|ensembl:ENST00000650711(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005335"("serotonin:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012505"(endomembrane system)|go:"GO:0014064"(positive regulation of serotonin secretion)|go:"GO:0015844"(monoamine transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019811"(cocaine binding)|go:"GO:0021941"(negative regulation of cerebellar granule cell precursor proliferation)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0035176"(social behavior)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0042713"(sperm ejaculation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051378"(serotonin binding)|go:"GO:0051610"(serotonin uptake)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0090067"(regulation of thalamus size)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099154"(serotonergic synapse)|interpro:IPR000175("Sodium:neurotransmitter symporter")|interpro:IPR013086("Sodium:neurotransmitter symporter, serotonin, N-terminal")|interpro:IPR037272|rcsb pdb:5I6X|rcsb pdb:5I6Z|rcsb pdb:5I71|rcsb pdb:5I73|rcsb pdb:5I74|rcsb pdb:5I75|rcsb pdb:6AWN|rcsb pdb:6AWO|rcsb pdb:6AWP|rcsb pdb:6AWQ|rcsb pdb:6DZV|rcsb pdb:6DZW|rcsb pdb:6DZY|rcsb pdb:6DZZ|rcsb pdb:6VRH|rcsb pdb:6VRK|rcsb pdb:6VRL|rcsb pdb:6W2B|rcsb pdb:6W2C|reactome:R-HSA-380615	-	-	-	figure legend:Table S2-125|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:mZYK0YEOl23+K9N0+v10I6r/Y4o9606	intact-crc:857F3A38B461EB00	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73390"	uniprotkb:P06401	intact:EBI-6656779	intact:EBI-78539|uniprotkb:Q8TDS3|uniprotkb:Q9UPF7|uniprotkb:A7X8B0|uniprotkb:B4E3T0|uniprotkb:A7LQ08|intact:EBI-28971228|ensembl:ENSP00000325120	psi-mi:r_5020_promegestone(display_short)|psi-mi:"CHEBI:73390"(display_long)	psi-mi:prgr_human(display_long)|uniprotkb:PGR(gene name)|psi-mi:PGR(display_short)|uniprotkb:NR3C3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 3(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656721|imex:IM-20536-117	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000263463|ensembl:ENSP00000263463|ensembl:ENSP00000325120|ensembl:ENST00000534013|ensembl:ENSP00000436561|refseq:NP_001258090.1|refseq:NP_000917.3|refseq:NP_001189403.1|refseq:NP_001258091.1|dip:DIP-5967N|ensembl:ENSG00000082175(gene)|ensembl:ENST00000325455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|interpro:IPR000128(Progesterone receptor, N-terminal)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P06401|rcsb pdb:1A28|rcsb pdb:1E3K|rcsb pdb:1SQN|rcsb pdb:1SR7|rcsb pdb:1ZUC|rcsb pdb:2C7A|rcsb pdb:2OVH|rcsb pdb:2OVM|rcsb pdb:2W8Y|rcsb pdb:3D90|rcsb pdb:3G8O|rcsb pdb:3HQ5|rcsb pdb:3KBA|rcsb pdb:3ZR7|rcsb pdb:3ZRA|rcsb pdb:3ZRB|rcsb pdb:4A2J|rcsb pdb:4APU|rcsb pdb:4OAR|rcsb pdb:5CC0|reactome:R-HSA-1251985|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-9018519	-	-	-	figure legend:Table S2-110|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:39.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:czItioijDkn48QgjyRtP9IaOvM09606	intact-crc:2202EFBD1E89B66E	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73390"	uniprotkb:P06401	intact:EBI-6656779	intact:EBI-78539|uniprotkb:Q8TDS3|uniprotkb:Q9UPF7|uniprotkb:A7X8B0|uniprotkb:B4E3T0|uniprotkb:A7LQ08|intact:EBI-28971228|ensembl:ENSP00000325120	psi-mi:r_5020_promegestone(display_short)|psi-mi:"CHEBI:73390"(display_long)	psi-mi:prgr_human(display_long)|uniprotkb:PGR(gene name)|psi-mi:PGR(display_short)|uniprotkb:NR3C3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 3(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656721|imex:IM-20536-117	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000263463|ensembl:ENSP00000263463|ensembl:ENSP00000325120|ensembl:ENST00000534013|ensembl:ENSP00000436561|refseq:NP_001258090.1|refseq:NP_000917.3|refseq:NP_001189403.1|refseq:NP_001258091.1|dip:DIP-5967N|ensembl:ENSG00000082175(gene)|ensembl:ENST00000325455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|interpro:IPR000128(Progesterone receptor, N-terminal)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P06401|rcsb pdb:1A28|rcsb pdb:1E3K|rcsb pdb:1SQN|rcsb pdb:1SR7|rcsb pdb:1ZUC|rcsb pdb:2C7A|rcsb pdb:2OVH|rcsb pdb:2OVM|rcsb pdb:2W8Y|rcsb pdb:3D90|rcsb pdb:3G8O|rcsb pdb:3HQ5|rcsb pdb:3KBA|rcsb pdb:3ZR7|rcsb pdb:3ZRA|rcsb pdb:3ZRB|rcsb pdb:4A2J|rcsb pdb:4APU|rcsb pdb:4OAR|rcsb pdb:5CC0|reactome:R-HSA-1251985|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-9018519	-	-	-	figure legend:Table S2-110|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:39.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:czItioijDkn48QgjyRtP9IaOvM09606	intact-crc:2202EFBD1E89B66E	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P35372	uniprotkb:P01210-PRO_0000008243	intact:EBI-2624570|uniprotkb:B0FXJ1|uniprotkb:B8Q1L8|uniprotkb:B8Q1L9|uniprotkb:Q6UPP1|uniprotkb:Q86V80|uniprotkb:G8XRH8|uniprotkb:B2R9S7|uniprotkb:B8Q1L7|uniprotkb:Q12930|uniprotkb:Q4VWM1|uniprotkb:Q4VWM2|uniprotkb:Q4VWM3|uniprotkb:Q4VWM4|uniprotkb:Q4VWM6|uniprotkb:Q4VWX6|uniprotkb:Q5TDA1|uniprotkb:Q6UQ80|uniprotkb:Q7Z2D8|uniprotkb:Q8IWW3|uniprotkb:Q8IWW4|uniprotkb:Q9UCZ4|uniprotkb:Q9UN57|uniprotkb:G8XRH6|ensembl:ENSP00000328264|uniprotkb:E7EWZ3	intact:EBI-6656055	psi-mi:oprm_human(display_long)|uniprotkb:OPRM1(gene name)|psi-mi:OPRM1(display_short)|uniprotkb:MOR1(gene name synonym)|uniprotkb:Mu opioid receptor(gene name synonym)|uniprotkb:Mu opiate receptor(gene name synonym)	psi-mi:p01210-pro_0000008243(display_long)|uniprotkb:PENK(gene name)|psi-mi:PENK(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656003|imex:IM-20536-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272453.1|refseq:NP_001272455.1|refseq:NP_001272456.1|refseq:NP_001272457.1|refseq:NP_001138752.1|refseq:NP_001138753.1|refseq:NP_001272452.1|refseq:NP_000905.3|refseq:NP_001008503.2|refseq:NP_001008504.2|refseq:NP_001008505.2|refseq:NP_001138751.1|refseq:NP_001138754.1|refseq:NP_001138755.1|refseq:NP_001138756.1|refseq:NP_001138757.1|refseq:NP_001138758.1|refseq:NP_001138759.1|refseq:XP_016866395.1|ensembl:ENSG00000112038(gene)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007600"(sensory perception)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031005"(filamin binding)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032094"(response to food)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|ensembl:ENST00000330432(transcript)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038047"(morphine receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004979"(beta-endorphin receptor activity)|go:"GO:0042755"(eating behavior)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0005768"(endosome)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061358"(negative regulation of Wnt protein secretion)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097444"(spine apparatus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000105(Mu opioid receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35372|reactome:R-HSA-111885|reactome:R-HSA-202040|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|reactome:R-HSA-418594|reactome:R-HSA-6785807|reactome:R-HSA-9022699|reactome:R-HSA-375276	intact:EBI-6656032(chain-parent)	-	-	chain-seq-start:100|chain-seq-end:104	figure legend:Table S2-87|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.57x10^-9(molar)	2013/04/23	2014/10/16	rogid:pfkhVhvpn9gSXiBRs1OBXJBCI3s9606	rogid:bz5sbFu/WDiWtYrAxeiR26fZRwg9606	intact-crc:1A6A77BCC222FF94|rigid:wVZWiVbWvBXfkEQ/6w3LnOlJtvc	false	-	methylated phenylalanine:4-4|mutation:5-5|mutation:2-2	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P35372	uniprotkb:P01210-PRO_0000008243	intact:EBI-2624570|uniprotkb:B0FXJ1|uniprotkb:B8Q1L8|uniprotkb:B8Q1L9|uniprotkb:Q6UPP1|uniprotkb:Q86V80|uniprotkb:G8XRH8|uniprotkb:B2R9S7|uniprotkb:B8Q1L7|uniprotkb:Q12930|uniprotkb:Q4VWM1|uniprotkb:Q4VWM2|uniprotkb:Q4VWM3|uniprotkb:Q4VWM4|uniprotkb:Q4VWM6|uniprotkb:Q4VWX6|uniprotkb:Q5TDA1|uniprotkb:Q6UQ80|uniprotkb:Q7Z2D8|uniprotkb:Q8IWW3|uniprotkb:Q8IWW4|uniprotkb:Q9UCZ4|uniprotkb:Q9UN57|uniprotkb:G8XRH6|ensembl:ENSP00000328264|uniprotkb:E7EWZ3	intact:EBI-6656055	psi-mi:oprm_human(display_long)|uniprotkb:OPRM1(gene name)|psi-mi:OPRM1(display_short)|uniprotkb:MOR1(gene name synonym)|uniprotkb:Mu opioid receptor(gene name synonym)|uniprotkb:Mu opiate receptor(gene name synonym)	psi-mi:p01210-pro_0000008243(display_long)|uniprotkb:PENK(gene name)|psi-mi:PENK(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656003|imex:IM-20536-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272453.1|refseq:NP_001272455.1|refseq:NP_001272456.1|refseq:NP_001272457.1|refseq:NP_001138752.1|refseq:NP_001138753.1|refseq:NP_001272452.1|refseq:NP_000905.3|refseq:NP_001008503.2|refseq:NP_001008504.2|refseq:NP_001008505.2|refseq:NP_001138751.1|refseq:NP_001138754.1|refseq:NP_001138755.1|refseq:NP_001138756.1|refseq:NP_001138757.1|refseq:NP_001138758.1|refseq:NP_001138759.1|refseq:XP_016866395.1|ensembl:ENSG00000112038(gene)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007600"(sensory perception)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031005"(filamin binding)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032094"(response to food)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|ensembl:ENST00000330432(transcript)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038047"(morphine receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004979"(beta-endorphin receptor activity)|go:"GO:0042755"(eating behavior)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0005768"(endosome)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061358"(negative regulation of Wnt protein secretion)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097444"(spine apparatus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000105(Mu opioid receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35372|reactome:R-HSA-111885|reactome:R-HSA-202040|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|reactome:R-HSA-418594|reactome:R-HSA-6785807|reactome:R-HSA-9022699|reactome:R-HSA-375276	intact:EBI-6656032(chain-parent)	-	-	chain-seq-start:100|chain-seq-end:104	figure legend:Table S2-87|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.57x10^-9(molar)	2013/04/23	2014/10/16	rogid:pfkhVhvpn9gSXiBRs1OBXJBCI3s9606	rogid:bz5sbFu/WDiWtYrAxeiR26fZRwg9606	intact-crc:1A6A77BCC222FF94|rigid:wVZWiVbWvBXfkEQ/6w3LnOlJtvc	false	-	N-methyl-L-phenylalanine:4-4|mutation:2-2|mutation:5-5|3h radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:4460"	uniprotkb:P32238	intact:EBI-6623716	intact:EBI-6623485|ensembl:ENSP00000295589|uniprotkb:B2R9Z5	psi-mi:devazepide(display_short)|psi-mi:"CHEBI:4460"(display_long)	psi-mi:cckar_human(display_long)|uniprotkb:CCKAR(gene name)|psi-mi:CCKAR(display_short)|uniprotkb:CCKRA(gene name synonym)|uniprotkb:Cholecystokinin-1 receptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623477|imex:IM-20536-74	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000163394(gene)|ensembl:ENST00000295589(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004951"(cholecystokinin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0016020"(membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030900"(forebrain development)|go:"GO:0038188"(cholecystokinin signaling pathway)|go:"GO:0046883"(regulation of hormone secretion)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000596(Cholecystokinin receptor, type A)|interpro:IPR009126(Cholecystokinin receptor)|interpro:IPR015276(Cholecystokinin A receptor, N-terminal)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR036472|mint:P32238|rcsb pdb:1D6G|rcsb pdb:1HZN|rcsb pdb:1PB2|rcsb pdb:7MBX|rcsb pdb:7MBY|reactome:R-HSA-375276|reactome:R-HSA-416476|refseq:NP_000721.1	-	-	-	figure legend:Table S2-29|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.71x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:Rztt+6h5ZHjM/fZTCETQI93bucU9606	intact-crc:19361B4A2995E73E	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:4460"	uniprotkb:P32238	intact:EBI-6623716	intact:EBI-6623485|ensembl:ENSP00000295589|uniprotkb:B2R9Z5	psi-mi:devazepide(display_short)|psi-mi:"CHEBI:4460"(display_long)	psi-mi:cckar_human(display_long)|uniprotkb:CCKAR(gene name)|psi-mi:CCKAR(display_short)|uniprotkb:CCKRA(gene name synonym)|uniprotkb:Cholecystokinin-1 receptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623477|imex:IM-20536-74	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000163394(gene)|ensembl:ENST00000295589(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004951"(cholecystokinin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0016020"(membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030900"(forebrain development)|go:"GO:0038188"(cholecystokinin signaling pathway)|go:"GO:0046883"(regulation of hormone secretion)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000596(Cholecystokinin receptor, type A)|interpro:IPR009126(Cholecystokinin receptor)|interpro:IPR015276(Cholecystokinin A receptor, N-terminal)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR036472|mint:P32238|rcsb pdb:1D6G|rcsb pdb:1HZN|rcsb pdb:1PB2|rcsb pdb:7MBX|rcsb pdb:7MBY|reactome:R-HSA-375276|reactome:R-HSA-416476|refseq:NP_000721.1	-	-	-	figure legend:Table S2-29|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.71x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:Rztt+6h5ZHjM/fZTCETQI93bucU9606	intact-crc:19361B4A2995E73E	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73294"	uniprotkb:P30411	intact:EBI-6623419	intact:EBI-6623386|ensembl:ENSP00000450482	psi-mi:npc-567(display_short)|psi-mi:"CHEBI:73294"(display_long)	psi-mi:bkrb2_human(display_long)|uniprotkb:BDKRB2(gene name)|psi-mi:BDKRB2(display_short)|uniprotkb:BKR2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623421|imex:IM-20536-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000168398(gene)|ensembl:ENST00000554311(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004947"(bradykinin receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008015"(blood circulation)|go:"GO:0009651"(response to salt stress)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042311"(vasodilation)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050482"(arachidonic acid secretion)|mint:P30411|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:1902239"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000496(Bradykinin receptor)|interpro:IPR001504(B2 bradykinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|refseq:NP_000614.1	-	-	-	figure legend:Table S2-22|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:7.6x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:RhTDfNBP7qLiPQUYuIAH1WKJZb09606	intact-crc:4C8863440FA22724	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P30411	uniprotkb:P01042-PRO_0000006688	intact:EBI-6623386|ensembl:ENSP00000450482	intact:EBI-6623273	psi-mi:bkrb2_human(display_long)|uniprotkb:BDKRB2(gene name)|psi-mi:BDKRB2(display_short)|uniprotkb:BKR2(gene name synonym)	psi-mi:p01042-pro_0000006688(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623421|imex:IM-20536-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168398(gene)|ensembl:ENST00000554311(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004947"(bradykinin receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008015"(blood circulation)|go:"GO:0009651"(response to salt stress)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042311"(vasodilation)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050482"(arachidonic acid secretion)|mint:P30411|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:1902239"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000496(Bradykinin receptor)|interpro:IPR001504(B2 bradykinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|refseq:NP_000614.1	intact:EBI-6378713(chain-parent)	-	-	chain-seq-start:381|chain-seq-end:389	figure legend:Table S2-22|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:7.6x10^-9(molar)	2013/04/23	2014/10/16	rogid:RhTDfNBP7qLiPQUYuIAH1WKJZb09606	rogid:6gWGwqbaJ8YYHgtSA8iAETGldvg9606	intact-crc:4C8863440FA22724	false	-	3h radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P24530	uniprotkb:P05305	intact:EBI-6624656|uniprotkb:A2A2Z8|uniprotkb:A8K3T4|uniprotkb:O15343|uniprotkb:Q59GB1|uniprotkb:Q5W0G9|uniprotkb:Q8NHM6|uniprotkb:Q8NHM7|uniprotkb:Q8NHM8|uniprotkb:Q8NHM9|uniprotkb:Q9UD23|uniprotkb:Q9UQK3|ensembl:ENSP00000487082|ensembl:ENSP00000493527|ensembl:ENSP00000493895|ensembl:ENSP00000494278	intact:EBI-715181|uniprotkb:Q96DA1|ensembl:ENSP00000368683	psi-mi:ednrb_human(display_long)|uniprotkb:EDNRB(gene name)|psi-mi:EDNRB(display_short)|uniprotkb:ETRB(gene name synonym)|uniprotkb:Endothelin receptor non-selective type(gene name synonym)	psi-mi:edn1_human(display_long)|uniprotkb:Preproendothelin-1(gene name synonym)|uniprotkb:EDN1(gene name)|psi-mi:EDN1(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624648|imex:IM-20536-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000106.1|refseq:NP_001116131.1|refseq:NP_001188326.1|refseq:NP_003982.1|ensembl:ENSG00000136160(gene)|ensembl:ENST00000475537(transcript)|ensembl:ENST00000646605(transcript)|ensembl:ENST00000646607(transcript)|ensembl:ENST00000646948(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004962"(endothelin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006885"(regulation of pH)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007497"(posterior midgut development)|go:"GO:0007568"(aging)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014043"(negative regulation of neuron maturation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014826"(vein smooth muscle contraction)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031620"(regulation of fever generation)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0035645"(enteric smooth muscle cell differentiation)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042311"(vasodilation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048265"(response to pain)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:1990839"(response to endothelin)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000499(Endothelin receptor)|interpro:IPR001112(Endothelin B receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P24530|rcsb pdb:5GLH|rcsb pdb:5GLI|rcsb pdb:5X93|rcsb pdb:5XPR|rcsb pdb:6IGK|rcsb pdb:6IGL|rcsb pdb:6LRY|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_001161791.1|refseq:NP_001946.3|refseq:XP_016865820.1|refseq:XP_011512632.1|refseq:XP_011512633.1|go:"GO:0007507"(heart development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007589"(body fluid secretion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010193"(response to ozone)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014826"(vein smooth muscle contraction)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030133"(transport vesicle)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031583"(phospholipase D-activating G protein-coupled receptor signaling pathway)|go:"GO:0031707"(endothelin A receptor binding)|go:"GO:0031708"(endothelin B receptor binding)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0042310"(vasoconstriction)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0033574"(response to testosterone)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0034696"(response to prostaglandin F)|go:"GO:0035094"(response to nicotine)|go:"GO:0035690"|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042313"(protein kinase C deactivation)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042482"(positive regulation of odontogenesis)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043179"(rhythmic excitation)|go:"GO:0043200"(response to amino acid)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044321"(response to leptin)|go:"GO:0045178"(basal part of cell)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048016"(inositol phosphate-mediated signaling)|go:"GO:0048237"(rough endoplasmic reticulum lumen)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0060298"(positive regulation of sarcomere organization)|go:"GO:0060585"(positive regulation of prostaglandin-endoperoxide synthase activity)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0030072"(peptide hormone secretion)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071389"(cellular response to mineralocorticoid stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902074"(response to salt)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR001928(Endothelin-like toxin)|interpro:IPR019764|interpro:IPR020475|rcsb pdb:1EDN|rcsb pdb:1EDP|rcsb pdb:1T7H|rcsb pdb:1V6R|rcsb pdb:5GLH|rcsb pdb:6DK5|reactome:R-HSA-375276|reactome:R-HSA-416476|ensembl:ENSG00000078401(gene)|ensembl:ENST00000379375(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001821"(histamine secretion)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006885"(regulation of pH)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)	-	-	-	figure legend:Table S2-39|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.12x10^-9(molar)	2013/04/23	2014/10/16	rogid:EVPfuNkUH6NzN8Jo1EjipkRmqSU9606	rogid:rQ9w4UJP9y2E/71at8Js4ZdXY/A9606	intact-crc:2D5C9C77D6C29B97|rigid:eX/64qnbrIAiY9e3liK2BDOF6GQ	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P24530	uniprotkb:P05305	intact:EBI-6624656|uniprotkb:A2A2Z8|uniprotkb:A8K3T4|uniprotkb:O15343|uniprotkb:Q59GB1|uniprotkb:Q5W0G9|uniprotkb:Q8NHM6|uniprotkb:Q8NHM7|uniprotkb:Q8NHM8|uniprotkb:Q8NHM9|uniprotkb:Q9UD23|uniprotkb:Q9UQK3|ensembl:ENSP00000487082|ensembl:ENSP00000493527|ensembl:ENSP00000493895|ensembl:ENSP00000494278	intact:EBI-715181|uniprotkb:Q96DA1|ensembl:ENSP00000368683	psi-mi:ednrb_human(display_long)|uniprotkb:EDNRB(gene name)|psi-mi:EDNRB(display_short)|uniprotkb:ETRB(gene name synonym)|uniprotkb:Endothelin receptor non-selective type(gene name synonym)	psi-mi:edn1_human(display_long)|uniprotkb:Preproendothelin-1(gene name synonym)|uniprotkb:EDN1(gene name)|psi-mi:EDN1(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624648|imex:IM-20536-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000106.1|refseq:NP_001116131.1|refseq:NP_001188326.1|refseq:NP_003982.1|ensembl:ENSG00000136160(gene)|ensembl:ENST00000475537(transcript)|ensembl:ENST00000646605(transcript)|ensembl:ENST00000646607(transcript)|ensembl:ENST00000646948(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004962"(endothelin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006885"(regulation of pH)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007497"(posterior midgut development)|go:"GO:0007568"(aging)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014043"(negative regulation of neuron maturation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014826"(vein smooth muscle contraction)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031620"(regulation of fever generation)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0035645"(enteric smooth muscle cell differentiation)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042311"(vasodilation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048265"(response to pain)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:1990839"(response to endothelin)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000499(Endothelin receptor)|interpro:IPR001112(Endothelin B receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P24530|rcsb pdb:5GLH|rcsb pdb:5GLI|rcsb pdb:5X93|rcsb pdb:5XPR|rcsb pdb:6IGK|rcsb pdb:6IGL|rcsb pdb:6LRY|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_001161791.1|refseq:NP_001946.3|refseq:XP_016865820.1|refseq:XP_011512632.1|refseq:XP_011512633.1|go:"GO:0007507"(heart development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007589"(body fluid secretion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010193"(response to ozone)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014826"(vein smooth muscle contraction)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030133"(transport vesicle)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031583"(phospholipase D-activating G protein-coupled receptor signaling pathway)|go:"GO:0031707"(endothelin A receptor binding)|go:"GO:0031708"(endothelin B receptor binding)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0042310"(vasoconstriction)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0033574"(response to testosterone)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0034696"(response to prostaglandin F)|go:"GO:0035094"(response to nicotine)|go:"GO:0035690"|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042313"(protein kinase C deactivation)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042482"(positive regulation of odontogenesis)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043179"(rhythmic excitation)|go:"GO:0043200"(response to amino acid)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044321"(response to leptin)|go:"GO:0045178"(basal part of cell)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048016"(inositol phosphate-mediated signaling)|go:"GO:0048237"(rough endoplasmic reticulum lumen)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0060298"(positive regulation of sarcomere organization)|go:"GO:0060585"(positive regulation of prostaglandin-endoperoxide synthase activity)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0030072"(peptide hormone secretion)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071389"(cellular response to mineralocorticoid stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902074"(response to salt)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR001928(Endothelin-like toxin)|interpro:IPR019764|interpro:IPR020475|rcsb pdb:1EDN|rcsb pdb:1EDP|rcsb pdb:1T7H|rcsb pdb:1V6R|rcsb pdb:5GLH|rcsb pdb:6DK5|reactome:R-HSA-375276|reactome:R-HSA-416476|ensembl:ENSG00000078401(gene)|ensembl:ENST00000379375(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001821"(histamine secretion)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006885"(regulation of pH)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)	-	-	-	figure legend:Table S2-39|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.12x10^-9(molar)	2013/04/23	2014/10/16	rogid:EVPfuNkUH6NzN8Jo1EjipkRmqSU9606	rogid:rQ9w4UJP9y2E/71at8Js4ZdXY/A9606	intact-crc:2D5C9C77D6C29B97|rigid:eX/64qnbrIAiY9e3liK2BDOF6GQ	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73297"	uniprotkb:P21728	intact:EBI-6624520	intact:EBI-6624459|intact:EBI-28969432|ensembl:ENSP00000377353|uniprotkb:B2RA44|uniprotkb:Q4QRJ0	psi-mi:sch_23390(display_short)|psi-mi:"CHEBI:73297"(display_long)	psi-mi:drd1_human(display_long)|uniprotkb:DRD1(gene name)|psi-mi:DRD1(display_short)|uniprotkb:Dopamine D1 receptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624523|imex:IM-20536-77	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000377353|ensembl:ENST00000393752(transcript)|go:"GO:0001588"(dopamine neurotransmitter receptor activity, coupled via Gs)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|ensembl:ENSG00000184845(gene)|go:"GO:0007617"(mating behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035240"(dopamine binding)|go:"GO:0042311"(vasodilation)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001413(Dopamine 1A receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1OZ5|rcsb pdb:7CKW|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CRH|rcsb pdb:7JOZ|go:"GO:0060170"(ciliary membrane)|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7LJC|go:"GO:0071870"(cellular response to catecholamine stimulus)|rcsb pdb:7LJD|reactome:R-HSA-390651|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903351"(cellular response to dopamine)|refseq:NP_000785.1	-	-	-	figure legend:Table S2-34|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:AFtjhLTHlY7MiBUIYqC5/3tHHxg9606	intact-crc:A20994201FA41CC6	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73295"	uniprotkb:P21554	intact:EBI-6623451	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:win 55212-2(display_short)|psi-mi:"CHEBI:73295"(display_long)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623461|imex:IM-20536-72	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	-	-	-	figure legend:Table S2-26|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	intact-crc:519B60198AE68F8A	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73410"	uniprotkb:P23975	intact:EBI-6661417	intact:EBI-6661391|ensembl:ENSP00000369237|ensembl:ENSP00000457473|uniprotkb:B2R707|uniprotkb:Q96KH8|uniprotkb:B4DX48	psi-mi:nisoxetine(display_short)|psi-mi:"CHEBI:73410"(display_long)	psi-mi:sc6a2_human(display_long)|uniprotkb:SLC6A2(gene name)|psi-mi:SLC6A2(display_short)|uniprotkb:NAT1(gene name synonym)|uniprotkb:NET1(gene name synonym)|uniprotkb:SLC6A5(gene name synonym)|uniprotkb:Norepinephrine transporter(gene name synonym)|uniprotkb:Solute carrier family 6 member 2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6661426|imex:IM-20536-123	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000103546(gene)|ensembl:ENST00000379906(transcript)|ensembl:ENST00000568943(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005328"("neurotransmitter:sodium symporter activity")|go:"GO:0005330"("dopamine:sodium symporter activity")|go:"GO:0005334"("norepinephrine:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0009986"(cell surface)|go:"GO:0015844"(monoamine transport)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0048265"(response to pain)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051620"(norepinephrine uptake)|go:"GO:0070050"(neuron cellular homeostasis)|interpro:IPR000175("Sodium:neurotransmitter symporter")|interpro:IPR002435("Sodium:neurotransmitter symporter, noradrenaline")|interpro:IPR037272|reactome:R-HSA-442660|reactome:R-HSA-5619109|go:"GO:0015874"(norepinephrine transport)|go:"GO:0016020"(membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|refseq:XP_011521597.1|refseq:NP_001034.1|refseq:NP_001165972.1|refseq:NP_001165975.1|refseq:NP_001165973.1|refseq:XP_006721326.1	-	-	-	figure legend:Table S2-121|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:hehF0DnHCYX/ZiRKE7nzQBciHyA9606	intact-crc:DF963933492CA44B	false	125i radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28790"	uniprotkb:P50406	intact:EBI-6656313	intact:EBI-1182222|uniprotkb:Q5TGZ1|uniprotkb:Q13640|ensembl:ENSP00000289753	psi-mi:serotonin(display_short)|psi-mi:"CHEBI:28790"(display_long)	psi-mi:5ht6r_human(display_long)|uniprotkb:Serotonin receptor 6(gene name synonym)|uniprotkb:HTR6(gene name)|psi-mi:HTR6(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656649|imex:IM-20536-111	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000862.1|ensembl:ENSG00000158748(gene)|ensembl:ENST00000289753(transcript)|go:"GO:0004969"(histamine receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0045202"(synapse)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002232(5-Hydroxytryptamine 6 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390666|reactome:R-HSA-418555|reactome:R-HSA-9660821	-	-	-	figure legend:Table S2-103|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:360.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:SFZIoXiv9N5u58vWFklEhUXJ9Wk9606	intact-crc:7C2B9A38AA7D2A04	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:6605"	uniprotkb:P50406	intact:EBI-6656639	intact:EBI-1182222|uniprotkb:Q5TGZ1|uniprotkb:Q13640|ensembl:ENSP00000289753	psi-mi:lsd-lysergic acid  diethylamide(display_short)|psi-mi:"CHEBI:6605"(display_long)	psi-mi:5ht6r_human(display_long)|uniprotkb:Serotonin receptor 6(gene name synonym)|uniprotkb:HTR6(gene name)|psi-mi:HTR6(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656649|imex:IM-20536-111	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000862.1|ensembl:ENSG00000158748(gene)|ensembl:ENST00000289753(transcript)|go:"GO:0004969"(histamine receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0045202"(synapse)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002232(5-Hydroxytryptamine 6 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390666|reactome:R-HSA-418555|reactome:R-HSA-9660821	-	-	-	figure legend:Table S2-103|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:360.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:SFZIoXiv9N5u58vWFklEhUXJ9Wk9606	intact-crc:7C2B9A38AA7D2A04	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P01042-PRO_0000006688	uniprotkb:P30411	intact:EBI-6623273	intact:EBI-6623386|ensembl:ENSP00000450482	psi-mi:p01042-pro_0000006688(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym)	psi-mi:bkrb2_human(display_long)|uniprotkb:BDKRB2(gene name)|psi-mi:BDKRB2(display_short)|uniprotkb:BKR2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623372|imex:IM-20536-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6378713(chain-parent)	ensembl:ENSG00000168398(gene)|ensembl:ENST00000554311(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004947"(bradykinin receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008015"(blood circulation)|go:"GO:0009651"(response to salt stress)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042311"(vasodilation)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050482"(arachidonic acid secretion)|mint:P30411|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:1902239"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000496(Bradykinin receptor)|interpro:IPR001504(B2 bradykinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|refseq:NP_000614.1	-	chain-seq-start:381|chain-seq-end:389	-	figure legend:Table S2-21|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:6gWGwqbaJ8YYHgtSA8iAETGldvg9606	rogid:RhTDfNBP7qLiPQUYuIAH1WKJZb09606	intact-crc:700839EAF9DFAA6A|rigid:xdMJrUn6gHWoOwaIzd8Zqb5VYEs	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:16467"	uniprotkb:P35228	intact:EBI-6662307	intact:EBI-6662224|uniprotkb:A1L3U5|uniprotkb:B7ZLY2|uniprotkb:O60757|uniprotkb:O94994|uniprotkb:Q16263|uniprotkb:Q16692|uniprotkb:Q4TTS5|uniprotkb:Q9UD42|ensembl:ENSP00000327251	psi-mi:arginine(display_short)|psi-mi:"CHEBI:16467"(display_long)	psi-mi:nos2_human(display_long)|uniprotkb:NOS2(gene name)|psi-mi:NOS2(display_short)|uniprotkb:NOS2A(gene name synonym)|uniprotkb:Hepatocyte NOS(gene name synonym)|uniprotkb:Inducible NO synthase(gene name synonym)|uniprotkb:NOS type II(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662317|imex:IM-20536-135	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011523161.1|refseq:NP_000616.3|dip:DIP-59359N|ensembl:ENSG00000007171(gene)|ensembl:ENST00000313735(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001912"(positive regulation of leukocyte mediated cytotoxicity)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0020037"(heme binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0032310"(prostaglandin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0035690"|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|rcsb pdb:1NSI|rcsb pdb:2LL6|rcsb pdb:2NSI|rcsb pdb:3E7G|rcsb pdb:3EJ8|rcsb pdb:3HR4|rcsb pdb:4CX7|rcsb pdb:4NOS|rcsb pdb:5TP6|rcsb pdb:5XN3|rcsb pdb:6JWM|rcsb pdb:6JWN|rcsb pdb:6KEY|reactome:R-HSA-1222556|reactome:R-HSA-392154|reactome:R-HSA-6785807|reactome:R-HSA-9033241|reactome:R-HSA-9636249	-	-	-	figure legend:Table S2-133|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:T1W4KxGaDieo3kQ8OTZjNXA4iF49606	intact-crc:D3B0B6A8015275D0	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:15843"	uniprotkb:P23219	intact:EBI-6662097	intact:EBI-6655935|ensembl:ENSP00000354612|uniprotkb:B4DHQ2|uniprotkb:A8K1V7|uniprotkb:Q15122|uniprotkb:Q5T7T6|uniprotkb:Q5T7T7|uniprotkb:Q5T7T8|uniprotkb:B4E2S5|uniprotkb:Q3HY28|uniprotkb:Q3HY29	psi-mi:arachidonic acid(display_short)|psi-mi:"CHEBI:15843"(display_long)	psi-mi:pgh1_human(display_long)|uniprotkb:PTGS1(gene name)|psi-mi:PTGS1(display_short)|uniprotkb:COX1(gene name synonym)|uniprotkb:Cyclooxygenase-1(gene name synonym)|uniprotkb:Prostaglandin H2 synthase 1(gene name synonym)|uniprotkb:Prostaglandin-endoperoxide synthase 1(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662101|imex:IM-20536-129	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000095303(gene)|ensembl:ENST00000362012(transcript)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004666"(prostaglandin-endoperoxide synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0020037"(heme binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR010255(Haem peroxidase)|interpro:IPR019791|interpro:IPR029580|interpro:IPR037120|rcsb pdb:6Y3C|reactome:R-HSA-2162123|reactome:R-HSA-140180|refseq:XP_011517178.1|refseq:NP_000953.2|refseq:NP_001258094.1|refseq:NP_542158.1|refseq:NP_001258095.1|refseq:NP_001258297.1	-	-	-	figure legend:Table S2-127|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:XNeWMly5H6EmY+3hq5bbAjBK4c09606	intact-crc:9CA3EC5E2BB0736C	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73357"	uniprotkb:P41145	intact:EBI-6655933	intact:EBI-925028|uniprotkb:Q499G4|uniprotkb:E5RHC9|ensembl:ENSP00000265572|ensembl:ENSP00000429706	psi-mi:u69593(display_short)|psi-mi:"CHEBI:73357"(display_long)	psi-mi:oprk_human(display_long)|uniprotkb:OPRK1(gene name)|psi-mi:OPRK1(display_short)|uniprotkb:OPRK(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655995|imex:IM-20536-98	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000903.2|refseq:NP_001305426.1|refseq:NP_001269833.1|ensembl:ENSG00000082556(gene)|ensembl:ENST00000265572(transcript)|ensembl:ENST00000520287(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0033685"(negative regulation of luteinizing hormone secretion)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038048"(dynorphin receptor activity)|go:"GO:0040017"(positive regulation of locomotion)|go:"GO:0042277"(peptide binding)|go:"GO:0042711"(maternal behavior)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044849"(estrous cycle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046877"(regulation of saliva secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0050951"(sensory perception of temperature stimulus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1903937"(response to acrylamide)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:1990708"(conditioned place preference)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000452(Kappa opioid receptor)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2A0D|rcsb pdb:2IQN|rcsb pdb:4DJH|rcsb pdb:6B73|rcsb pdb:6VI4|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-9022699	-	-	-	figure legend:Table S2-86|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:UJUQfTpWND3otpIeautU4Nx0Ru49606	intact-crc:D5142E3700CF8E09	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P47211	uniprotkb:P22466-PRO_0000010449	intact:EBI-6624741|ensembl:ENSP00000299727|uniprotkb:Q4VBL7	intact:EBI-6624800	psi-mi:galr1_human(display_long)|uniprotkb:GALR1(gene name)|psi-mi:GALR1(display_short)|uniprotkb:GALNR(gene name synonym)|uniprotkb:GALNR1(gene name synonym)	psi-mi:p22466-pro_0000010449(display_long)|uniprotkb:GAL(gene name)|psi-mi:GAL(display_short)|uniprotkb:GAL1(gene name synonym)|uniprotkb:GALN(gene name synonym)|uniprotkb:GLNN(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624824|imex:IM-20536-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166573(gene)|ensembl:ENST00000299727(transcript)|go:"GO:0004966"(galanin receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051464"(positive regulation of cortisol secretion)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000405(Galanin receptor)|interpro:IPR003906(Galanin 1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_001471.2	intact:EBI-6624768(chain-parent)	-	-	chain-seq-start:33|chain-seq-end:62	figure legend:Table S2-42|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:2cyPncH8b79+lmM6piQTdEAS3h89606	rogid:Ap3LftulUqpof4tpDP+DuCa2Kiw9606	intact-crc:1ECF94D74AB6A938|rigid:ftuxRv5JkNp8cGEwUHMeFxi0+Fc	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P06307-PRO_0000010542	uniprotkb:P32239	intact:EBI-6624436	intact:EBI-1753137|uniprotkb:A8K7P9|uniprotkb:O75824|uniprotkb:Q16144|uniprotkb:Q92492|uniprotkb:Q96LC6|uniprotkb:Q9NYK7|uniprotkb:Q9UBV1|ensembl:ENSP00000335544	psi-mi:p06307-pro_0000010542(display_long)|uniprotkb:CCK(gene name)|psi-mi:CCK(display_short)	psi-mi:gasr_human(display_long)|uniprotkb:CCKBR(gene name)|psi-mi:CCKBR(display_short)|uniprotkb:CCKRB(gene name synonym)|uniprotkb:Cholecystokinin-2 receptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624443|imex:IM-20536-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6624398(chain-parent)	refseq:NP_795344.1|refseq:XP_005253267.1|refseq:NP_001304958.1|refseq:XP_016874005.1|dip:DIP-229N|go:"GO:0031741"(type B gastrin/cholecystokinin receptor binding)|go:"GO:0038188"(cholecystokinin signaling pathway)|go:"GO:0045851"(pH reduction)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0048565"(digestive tract development)|go:"GO:0048732"(gland development)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000314(Gastrin receptor)|interpro:IPR009126(Cholecystokinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P32239|rcsb pdb:1L4T|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-881907|go:"GO:0017046"(peptide hormone binding)|ensembl:ENSG00000110148(gene)|ensembl:ENST00000334619(transcript)|go:"GO:0001696"(gastric acid secretion)|go:"GO:0004951"(cholecystokinin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015054"(gastrin receptor activity)|go:"GO:0016021"(integral component of membrane)	-	chain-seq-start:96|chain-seq-end:103	-	figure legend:Table S2-32|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:4lN3IKpzLMShDTVjTiIj/NfwYmE9606	rogid:wmvdbFzpde5hkgKlLrXxAJdZd8s9606	intact-crc:A9C6D0A04347BD40|rigid:4ZMKQacLjilTv7RZvmRLEHv26SY	false	125i radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:8247"	uniprotkb:P11229	intact:EBI-6655159	intact:EBI-2624759|ensembl:ENSP00000306490|uniprotkb:Q96RH1	psi-mi:pirenzepine/gastrozepin(display_short)|psi-mi:"CHEBI:8247"(display_long)	psi-mi:acm1_human(display_long)|uniprotkb:CHRM1(gene name)|psi-mi:CHRM1(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655161|imex:IM-20536-87	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000168539(gene)|ensembl:ENST00000306960(transcript)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007399"(nervous system development)|refseq:XP_011543044.1|refseq:NP_000729.2|go:"GO:0016020"(membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043679"(axon terminus)|go:"GO:0045202"(synapse)|go:"GO:0046541"(saliva secretion)|go:"GO:0050890"(cognition)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002228(Muscarinic acetylcholine receptor M1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5CXV|rcsb pdb:6OIJ|rcsb pdb:6WJC|reactome:R-HSA-390648|reactome:R-HSA-416476|interpro:IPR000995(Muscarinic acetylcholine receptor)	-	-	-	figure legend:Table S2-62|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:h4KvtChdArk35BJmdzgVwGfbc4A9606	intact-crc:809322E7B7B6A3DA	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73288"	uniprotkb:P08588	intact:EBI-6622766	intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4	psi-mi:cgp 12177(display_short)|psi-mi:"CHEBI:73288"(display_long)	psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622760|imex:IM-20536-64	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N	-	-	-	figure legend:Table S2-9|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606	intact-crc:31F9CCC6A33418E3	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9UHF0-PRO_0000033566	uniprotkb:P29371	intact:EBI-6655626	intact:EBI-6655576|ensembl:ENSP00000303325|uniprotkb:Q0P510	psi-mi:q9uhf0-pro_0000033566(display_long)|uniprotkb:TAC3(gene name)|psi-mi:TAC3(display_short)|uniprotkb:NKNB(gene name synonym)|uniprotkb:ZNEUROK1(gene name synonym)|uniprotkb:UNQ585/PRO1155(orf name)	psi-mi:nk3r_human(display_long)|uniprotkb:TACR3(gene name)|psi-mi:TACR3(display_short)|uniprotkb:NK3R(gene name synonym)|uniprotkb:TAC3R(gene name synonym)|uniprotkb:NK-3 receptor(gene name synonym)|uniprotkb:Neurokinin B receptor(gene name synonym)|uniprotkb:Tachykinin receptor 3(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655560|imex:IM-20536-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-717325(chain-parent)	ensembl:ENSG00000169836(gene)|ensembl:ENST00000304883(transcript)|go:"GO:0004995"(tachykinin receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0032355"(response to estradiol)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0043278"(response to morphine)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0097225"(sperm midpiece)|go:"GO:1902093"(positive regulation of flagellated sperm motility)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001013(Neurokinin NK3 receptor)|interpro:IPR001681(Neurokinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-380095|reactome:R-HSA-416476|refseq:NP_001050.1	-	chain-seq-start:81|chain-seq-end:90	-	figure legend:Table S2-75|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:Fw8j1ko6ncMYd3kHssclum277e09606	rogid:s8o+d0WYwijf/csy+KXJav3pBtQ9606	intact-crc:8555E1898BCEDE3F|rigid:S21Jp3vRMrTq8ijoY8RX6MrAKHc	false	125i radiolabel:?-?|mutation:7-7	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73287"	uniprotkb:P08913	intact:EBI-6622747	intact:EBI-6622671|ensembl:ENSP00000280155|uniprotkb:B0LPF6|uniprotkb:Q2I8G2|uniprotkb:Q2XN99|uniprotkb:Q86TH8|uniprotkb:Q9BZK1	psi-mi:rx-821002(display_short)|psi-mi:"CHEBI:73287"(display_long)	psi-mi:ada2a_human(display_long)|uniprotkb:ADRA2A(gene name)|psi-mi:ADRA2A(display_short)|uniprotkb:ADRA2R(gene name synonym)|uniprotkb:ADRAR(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C10(gene name synonym)|uniprotkb:Alpha-2A adrenoreceptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622665|imex:IM-20536-62	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000150594(gene)|ensembl:ENST00000280155(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031696"(alpha-2C adrenergic receptor binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042596"(fear response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071881"(adenylate cyclase-inhibiting adrenergic receptor signaling pathway)|go:"GO:0071882"(phospholipase C-activating adrenergic receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001946(Adrenergic receptor, alpha-2A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1HLL|rcsb pdb:1HO9|rcsb pdb:1HOD|rcsb pdb:1HOF|rcsb pdb:6K42|rcsb pdb:6KUX|rcsb pdb:6KUY|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000672.3|dip:DIP-61452N	-	-	-	figure legend:Table S2-7|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2020/01/08	-	rogid:U+fZeOEBa5ofBs8XfKYhxPYeNhY9606	intact-crc:A2C076890F0E1705	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:6605"	uniprotkb:P47898	intact:EBI-6656639	intact:EBI-6656588|ensembl:ENSP00000287907|uniprotkb:Q2M2D2	psi-mi:lsd-lysergic acid  diethylamide(display_short)|psi-mi:"CHEBI:6605"(display_long)	psi-mi:5ht5a_human(display_long)|uniprotkb:HTR5A(gene name)|psi-mi:HTR5A(display_short)|uniprotkb:Serotonin receptor 5A(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656641|imex:IM-20536-110	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|ensembl:ENSG00000157219(gene)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0021766"(hippocampus development)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0043204"(perikaryon)|go:"GO:0051378"(serotonin binding)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001397(5-Hydroxytryptamine 5A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390666|reactome:R-HSA-418594|ensembl:ENST00000287907(transcript)|refseq:NP_076917.1	-	-	-	figure legend:Table S2-102|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:DX9z1YvHoUG2SKUGvc8xsGYXVB09606	intact-crc:188293E7F369473E	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73283"	uniprotkb:P29274	intact:EBI-6622601	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	psi-mi:cgs-21680(display_short)|psi-mi:"CHEBI:73283"(display_long)	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622595|imex:IM-20536-58	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	-	-	-	figure legend:Table S2-3|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	intact-crc:B601F9D6C4A9CB5C	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:34849"	uniprotkb:P10275	intact:EBI-6656801	intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6	psi-mi:mibolerone(display_short)|psi-mi:"CHEBI:34849"(display_long)	psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656803|imex:IM-20536-121	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N	-	-	-	figure legend:Table S2-113|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2016/03/30	-	rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606	intact-crc:41569201B7AAE52B	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73390"	uniprotkb:P06401	intact:EBI-6656779	intact:EBI-78539|uniprotkb:Q8TDS3|uniprotkb:Q9UPF7|uniprotkb:A7X8B0|uniprotkb:B4E3T0|uniprotkb:A7LQ08|intact:EBI-28971228|ensembl:ENSP00000325120	psi-mi:r_5020_promegestone(display_short)|psi-mi:"CHEBI:73390"(display_long)	psi-mi:prgr_human(display_long)|uniprotkb:PGR(gene name)|psi-mi:PGR(display_short)|uniprotkb:NR3C3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 3(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656783|imex:IM-20536-119	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000263463|ensembl:ENSP00000263463|ensembl:ENSP00000325120|ensembl:ENST00000534013|ensembl:ENSP00000436561|refseq:NP_001258090.1|refseq:NP_000917.3|refseq:NP_001189403.1|refseq:NP_001258091.1|dip:DIP-5967N|ensembl:ENSG00000082175(gene)|ensembl:ENST00000325455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|interpro:IPR000128(Progesterone receptor, N-terminal)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P06401|rcsb pdb:1A28|rcsb pdb:1E3K|rcsb pdb:1SQN|rcsb pdb:1SR7|rcsb pdb:1ZUC|rcsb pdb:2C7A|rcsb pdb:2OVH|rcsb pdb:2OVM|rcsb pdb:2W8Y|rcsb pdb:3D90|rcsb pdb:3G8O|rcsb pdb:3HQ5|rcsb pdb:3KBA|rcsb pdb:3ZR7|rcsb pdb:3ZRA|rcsb pdb:3ZRB|rcsb pdb:4A2J|rcsb pdb:4APU|rcsb pdb:4OAR|rcsb pdb:5CC0|reactome:R-HSA-1251985|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-9018519	-	-	-	figure legend:Table S2-111|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:czItioijDkn48QgjyRtP9IaOvM09606	intact-crc:D7059DE7D9A92E46	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:6123"	uniprotkb:P28223	intact:EBI-6656382	intact:EBI-6656333|ensembl:ENSP00000437737|uniprotkb:B2RAC5|uniprotkb:B4DZ79|uniprotkb:F5GWE8|uniprotkb:Q5T8C0	psi-mi:ketanserin(display_short)|psi-mi:"CHEBI:6123"(display_long)	psi-mi:5ht2a_human(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656384|imex:IM-20536-104	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030431"(sleep)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044380"(protein localization to cytoskeleton)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070852"(cell body fiber)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000455(5-Hydroxytryptamine 2A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6A93|rcsb pdb:6A94|rcsb pdb:6WGT|rcsb pdb:6WH4|rcsb pdb:6WHA|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051378"(serotonin binding)|refseq:NP_000612.1|refseq:NP_001159419.1|dip:DIP-41844N	-	-	-	figure legend:Table S2-96|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	intact-crc:7B99FE38C2A7C56E	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73285"	uniprotkb:P33765	intact:EBI-6622653	intact:EBI-6622619|uniprotkb:A2A3P4|uniprotkb:Q6UWU0|uniprotkb:Q9BYZ1|uniprotkb:P0DMS8	psi-mi:ab-meca(display_short)|psi-mi:"CHEBI:73285"(display_long)	psi-mi:aa3r_human(display_long)|uniprotkb:ADORA3(gene name)|psi-mi:ADORA3(display_short)|uniprotkb:UNQ1931/PRO4406(orf name)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622613|imex:IM-20536-60	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0042629"(mast cell granule)|interpro:IPR000466(Adenosine A3 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0006954"(inflammatory response)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0007165"(signal transduction)|refseq:NP_000668.1|refseq:NP_065734.5|rcsb pdb:1OEA|rcsb pdb:1R7N|reactome:REACT_18288|reactome:REACT_19231|ensembl:ENSG00000121933|ensembl:ENSP00000241356|ensembl:ENSP00000358730|go:"GO:0005886"(plasma membrane)|go:"GO:0009611"(response to wounding)|ensembl:ENST00000241356|ensembl:ENST00000369716|ensembl:ENSG00000282608|reactome:R-HSA-417973|reactome:R-HSA-418594|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)	-	-	-	figure legend:Table S2-5|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:HnLwBgguLQ+9gQg1ReMPZbD/E0U9606	intact-crc:6B3ED09F5217605B	false	125i radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P37288	uniprotkb:P01185-PRO_0000020515	intact:EBI-6656842|ensembl:ENSP00000299178	intact:EBI-6858081	psi-mi:v1ar_human(display_long)|uniprotkb:AVPR1A(gene name)|psi-mi:AVPR1A(display_short)|uniprotkb:AVPR1(gene name synonym)|uniprotkb:AVPR V1a(gene name synonym)|uniprotkb:Antidiuretic hormone receptor 1a(gene name synonym)|uniprotkb:Vascular/hepatic-type arginine vasopressin receptor(gene name synonym)	psi-mi:p01185-pro_0000020515(display_long)|uniprotkb:AVP(gene name)|psi-mi:AVP(display_short)|uniprotkb:ARVP(gene name synonym)|uniprotkb:VP(gene name synonym)|uniprotkb:AVP-NPII(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656834|imex:IM-20536-52	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166148(gene)|ensembl:ENST00000299178(transcript)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0002125"(maternal aggressive behavior)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007621"(negative regulation of female receptivity)|go:"GO:0007625"(grooming behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021537"(telencephalon development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031894"(V1A vasopressin receptor binding)|go:"GO:0032849"(positive regulation of cellular pH reduction)|go:"GO:0035176"(social behavior)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042277"(peptide binding)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0043084"(penile erection)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051970"(negative regulation of transmission of nerve impulse)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001224(Vasopressin V1A receptor)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR015076(Region of unknown function DUF1856)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1YTV|reactome:R-HSA-388479|reactome:R-HSA-416476|reactome:R-HSA-5619099|refseq:NP_000697.1	intact:EBI-6858021(chain-parent)	-	-	chain-seq-start:20|chain-seq-end:28|comment:"This molecule is probably H-5350 from Bachem:-  β-Mercapto-β,β-cyclopentamethylene-propionyl-Tyr(Me)-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2    (d(CH2)5 1,Tyr(Me)2,Arg8)-Vasopressin"	figure legend:Table S2-116|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.9x10^-9(molar)	2013/04/23	2014/10/16	rogid:5abwd21TO9yfkHn1yTWTQlFE1489606	rogid:qcHswshPccKuRWuxzG1OJMDIZFg9606	intact-crc:995069D45F4D426E|rigid:Tgmdy3w7PG8GZRKlhKSMAf8/8OI	false	-	sufficient binding region:2-9|methylated tyrosine:2-2|uncategorized protein modification:2-2	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P37288	uniprotkb:P01185-PRO_0000020515	intact:EBI-6656842|ensembl:ENSP00000299178	intact:EBI-6858081	psi-mi:v1ar_human(display_long)|uniprotkb:AVPR1A(gene name)|psi-mi:AVPR1A(display_short)|uniprotkb:AVPR1(gene name synonym)|uniprotkb:AVPR V1a(gene name synonym)|uniprotkb:Antidiuretic hormone receptor 1a(gene name synonym)|uniprotkb:Vascular/hepatic-type arginine vasopressin receptor(gene name synonym)	psi-mi:p01185-pro_0000020515(display_long)|uniprotkb:AVP(gene name)|psi-mi:AVP(display_short)|uniprotkb:ARVP(gene name synonym)|uniprotkb:VP(gene name synonym)|uniprotkb:AVP-NPII(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656834|imex:IM-20536-52	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166148(gene)|ensembl:ENST00000299178(transcript)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0002125"(maternal aggressive behavior)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007621"(negative regulation of female receptivity)|go:"GO:0007625"(grooming behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021537"(telencephalon development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031894"(V1A vasopressin receptor binding)|go:"GO:0032849"(positive regulation of cellular pH reduction)|go:"GO:0035176"(social behavior)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042277"(peptide binding)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0043084"(penile erection)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051970"(negative regulation of transmission of nerve impulse)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001224(Vasopressin V1A receptor)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR015076(Region of unknown function DUF1856)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1YTV|reactome:R-HSA-388479|reactome:R-HSA-416476|reactome:R-HSA-5619099|refseq:NP_000697.1	intact:EBI-6858021(chain-parent)	-	-	chain-seq-start:20|chain-seq-end:28	figure legend:Table S2-116|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.9x10^-9(molar)	2013/04/23	2014/10/16	rogid:5abwd21TO9yfkHn1yTWTQlFE1489606	rogid:qcHswshPccKuRWuxzG1OJMDIZFg9606	intact-crc:995069D45F4D426E|rigid:Tgmdy3w7PG8GZRKlhKSMAf8/8OI	false	-	3h radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P21452	uniprotkb:P20366-PRO_0000033534	intact:EBI-6655413|ensembl:ENSP00000362403|uniprotkb:A8K7I1|uniprotkb:Q4QRI5|uniprotkb:Q8NGQ8|uniprotkb:Q9UDE6|uniprotkb:Q9UDE7	intact:EBI-6655449	psi-mi:nk2r_human(display_long)|uniprotkb:TACR2(gene name)|psi-mi:TACR2(display_short)|uniprotkb:NK2R(gene name synonym)|uniprotkb:NKNAR(gene name synonym)|uniprotkb:TAC2R(gene name synonym)|uniprotkb:NK-2 receptor(gene name synonym)|uniprotkb:Neurokinin A receptor(gene name synonym)|uniprotkb:Tachykinin receptor 2(gene name synonym)	psi-mi:p20366-pro_0000033534(display_long)|uniprotkb:TAC1(gene name)|psi-mi:TAC1(display_short)|uniprotkb:NKA(gene name synonym)|uniprotkb:NKNA(gene name synonym)|uniprotkb:TAC2(gene name synonym)|uniprotkb:PPT(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655542|imex:IM-20536-36	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000075073(gene)|ensembl:ENST00000373306(transcript)|go:"GO:0004995"(tachykinin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014827"(intestine smooth muscle contraction)|go:"GO:0016497"(substance K receptor activity)|go:"GO:0033685"(negative regulation of luteinizing hormone secretion)|go:"GO:0035106"(operant conditioning)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061827"(sperm head)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0097225"(sperm midpiece)|go:"GO:1902093"(positive regulation of flagellated sperm motility)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000913(Neurokinin NK2 receptor)|interpro:IPR001681(Neurokinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-380095|reactome:R-HSA-416476|go:"GO:0006936"(muscle contraction)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007588"(excretion)|refseq:NP_001048.2	intact:EBI-717291(chain-parent)	-	-	chain-seq-start:98|chain-seq-end:107	figure legend:Table S2-74|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:14.0x10^-9(molar)	2013/04/23	2014/10/16	rogid:uJSOYMX5h4Vmd1Q34xaBobs39mg9606	rogid:/rjPbrRHAVerwGGyd9WHq5Zu90o9606	intact-crc:12A461AF87086504|rigid:HgJnOMykkRRuUuAdU4BLd2pIJCA	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P21452	uniprotkb:P20366-PRO_0000033534	intact:EBI-6655413|ensembl:ENSP00000362403|uniprotkb:A8K7I1|uniprotkb:Q4QRI5|uniprotkb:Q8NGQ8|uniprotkb:Q9UDE6|uniprotkb:Q9UDE7	intact:EBI-6655449	psi-mi:nk2r_human(display_long)|uniprotkb:TACR2(gene name)|psi-mi:TACR2(display_short)|uniprotkb:NK2R(gene name synonym)|uniprotkb:NKNAR(gene name synonym)|uniprotkb:TAC2R(gene name synonym)|uniprotkb:NK-2 receptor(gene name synonym)|uniprotkb:Neurokinin A receptor(gene name synonym)|uniprotkb:Tachykinin receptor 2(gene name synonym)	psi-mi:p20366-pro_0000033534(display_long)|uniprotkb:TAC1(gene name)|psi-mi:TAC1(display_short)|uniprotkb:NKA(gene name synonym)|uniprotkb:NKNA(gene name synonym)|uniprotkb:TAC2(gene name synonym)|uniprotkb:PPT(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655542|imex:IM-20536-36	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000075073(gene)|ensembl:ENST00000373306(transcript)|go:"GO:0004995"(tachykinin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014827"(intestine smooth muscle contraction)|go:"GO:0016497"(substance K receptor activity)|go:"GO:0033685"(negative regulation of luteinizing hormone secretion)|go:"GO:0035106"(operant conditioning)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061827"(sperm head)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0097225"(sperm midpiece)|go:"GO:1902093"(positive regulation of flagellated sperm motility)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000913(Neurokinin NK2 receptor)|interpro:IPR001681(Neurokinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-380095|reactome:R-HSA-416476|go:"GO:0006936"(muscle contraction)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007588"(excretion)|refseq:NP_001048.2	intact:EBI-717291(chain-parent)	-	-	chain-seq-start:98|chain-seq-end:107	figure legend:Table S2-74|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:14.0x10^-9(molar)	2013/04/23	2014/10/16	rogid:uJSOYMX5h4Vmd1Q34xaBobs39mg9606	rogid:/rjPbrRHAVerwGGyd9WHq5Zu90o9606	intact-crc:12A461AF87086504|rigid:HgJnOMykkRRuUuAdU4BLd2pIJCA	false	-	N-methyl-L-leucine:9-9|mutation:5-5|mutation:10-10|sufficient binding region:4-10	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P50052	uniprotkb:P01017-PRO_0000032443	intact:EBI-1748067|uniprotkb:Q13016|uniprotkb:Q6FGY7|uniprotkb:B2R9V1|ensembl:ENSP00000360973|ensembl:ENSP00000505750	intact:EBI-6623100	psi-mi:agtr2_human(display_long)|uniprotkb:AGTR2(gene name)|psi-mi:AGTR2(display_short)|uniprotkb:Angiotensin II type-2 receptor(gene name synonym)	psi-mi:p01017-pro_0000032443(display_long)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)|uniprotkb:Serpin A8(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623110|imex:IM-20536-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000677.2|refseq:XP_011535835.1|ensembl:ENSG00000180772(gene)|ensembl:ENST00000371906(transcript)|ensembl:ENST00000681852(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0001991"(regulation of systemic arterial blood pressure by circulatory renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032304"(negative regulation of icosanoid secretion)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0035932"(aldosterone secretion)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000147(AT2 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5UNF|rcsb pdb:5UNG|rcsb pdb:5UNH|rcsb pdb:6JOD|reactome:R-HSA-375276|reactome:R-HSA-418594	intact:EBI-6623088(chain-parent)	-	-	chain-seq-start:25|chain-seq-end:32	figure legend:Table S2-16|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.69x10^-9(molar)	2013/04/23	2014/10/16	rogid:tXWI4w7l3DHAfmhthRZY9Hxrvus9606	rogid:Y7v3gjqD+W7BUKBXqJK3NeZ/JNY9913	intact-crc:0C5DDCCEAE99AD1D|rigid:RNzdlJwyPAy4IIP8V2vWgCqkhqs	false	-	mutation:1-1|mutation:8-8	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P50052	uniprotkb:P01019-PRO_0000032459	intact:EBI-1748067|uniprotkb:Q13016|uniprotkb:Q6FGY7|uniprotkb:B2R9V1|ensembl:ENSP00000360973|ensembl:ENSP00000505750	intact:EBI-2927577	psi-mi:agtr2_human(display_long)|uniprotkb:AGTR2(gene name)|psi-mi:AGTR2(display_short)|uniprotkb:Angiotensin II type-2 receptor(gene name synonym)	psi-mi:p01019-pro_0000032459(display_long)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)|uniprotkb:Serpin A8(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623110|imex:IM-20536-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000677.2|refseq:XP_011535835.1|ensembl:ENSG00000180772(gene)|ensembl:ENST00000371906(transcript)|ensembl:ENST00000681852(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0001991"(regulation of systemic arterial blood pressure by circulatory renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032304"(negative regulation of icosanoid secretion)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0035932"(aldosterone secretion)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000147(AT2 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5UNF|rcsb pdb:5UNG|rcsb pdb:5UNH|rcsb pdb:6JOD|reactome:R-HSA-375276|reactome:R-HSA-418594	intact:EBI-751728(chain-parent)	-	-	chain-seq-start:35|chain-seq-end:41	figure legend:Table S2-16|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.69x10^-9(molar)	2013/04/23	2014/10/16	rogid:tXWI4w7l3DHAfmhthRZY9Hxrvus9606	rogid:bFZEQAk7GJqer1R8daO4K+hXwPQ9606	intact-crc:0C5DDCCEAE99AD1D|rigid:RNzdlJwyPAy4IIP8V2vWgCqkhqs	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O43603	uniprotkb:P22466-PRO_0000010449	intact:EBI-6624855|ensembl:ENSP00000329684|uniprotkb:A5JUU4|uniprotkb:Q32MN8	intact:EBI-6624800	psi-mi:galr2_human(display_long)|uniprotkb:GALR2(gene name)|psi-mi:GALR2(display_short)|uniprotkb:GALNR2(gene name synonym)	psi-mi:p22466-pro_0000010449(display_long)|uniprotkb:GAL(gene name)|psi-mi:GAL(display_short)|uniprotkb:GAL1(gene name synonym)|uniprotkb:GALN(gene name synonym)|uniprotkb:GLNN(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624842|imex:IM-20536-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000182687(gene)|ensembl:ENST00000329003(transcript)|go:"GO:0004966"(galanin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007611"(learning or memory)|go:"GO:0005929"(cilium)|go:"GO:0007631"(feeding behavior)|go:"GO:0006936"(muscle contraction)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0090663"(galanin-activated signaling pathway)|go:"GO:1902608"(positive regulation of large conductance calcium-activated potassium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000405(Galanin receptor)|go:"GO:0007218"(neuropeptide signaling pathway)|interpro:IPR003907(Galanin 2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_003848.1	intact:EBI-6624768(chain-parent)	-	-	chain-seq-start:33|chain-seq-end:62	figure legend:Table S2-43|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.4x10^-9(molar)	2013/04/23	2014/10/16	rogid:oOMJXr3SMk2TzwRk4CHvuTPCpeQ9606	rogid:Ap3LftulUqpof4tpDP+DuCa2Kiw9606	intact-crc:7C76CACE6AF78438|rigid:g1/md0o3eNvSexKe+HqMw9vqtU0	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O43603	uniprotkb:P22466-PRO_0000010449	intact:EBI-6624855|ensembl:ENSP00000329684|uniprotkb:A5JUU4|uniprotkb:Q32MN8	intact:EBI-6624800	psi-mi:galr2_human(display_long)|uniprotkb:GALR2(gene name)|psi-mi:GALR2(display_short)|uniprotkb:GALNR2(gene name synonym)	psi-mi:p22466-pro_0000010449(display_long)|uniprotkb:GAL(gene name)|psi-mi:GAL(display_short)|uniprotkb:GAL1(gene name synonym)|uniprotkb:GALN(gene name synonym)|uniprotkb:GLNN(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624842|imex:IM-20536-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000182687(gene)|ensembl:ENST00000329003(transcript)|go:"GO:0004966"(galanin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007611"(learning or memory)|go:"GO:0005929"(cilium)|go:"GO:0007631"(feeding behavior)|go:"GO:0006936"(muscle contraction)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0090663"(galanin-activated signaling pathway)|go:"GO:1902608"(positive regulation of large conductance calcium-activated potassium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000405(Galanin receptor)|go:"GO:0007218"(neuropeptide signaling pathway)|interpro:IPR003907(Galanin 2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_003848.1	intact:EBI-6624768(chain-parent)	-	-	chain-seq-start:33|chain-seq-end:62	figure legend:Table S2-43|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.4x10^-9(molar)	2013/04/23	2014/10/16	rogid:oOMJXr3SMk2TzwRk4CHvuTPCpeQ9606	rogid:Ap3LftulUqpof4tpDP+DuCa2Kiw9606	intact-crc:7C76CACE6AF78438|rigid:g1/md0o3eNvSexKe+HqMw9vqtU0	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P51677	uniprotkb:P51671	intact:EBI-6625120|ensembl:ENSP00000350003|ensembl:ENSP00000379271|ensembl:ENSP00000379273|uniprotkb:B3KVQ1|uniprotkb:Q15748|uniprotkb:Q2YDB9|uniprotkb:Q86WD2|uniprotkb:Q9ULY8|uniprotkb:F5GWL6|uniprotkb:Q8TDP6	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	psi-mi:ccr3_human(display_long)|uniprotkb:CCR3(gene name)|psi-mi:CCR3(display_short)|uniprotkb:CMKBR3(gene name synonym)|uniprotkb:Eosinophil eotaxin receptor(gene name synonym)	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6625054|imex:IM-20536-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183625(gene)|ensembl:ENST00000395940(transcript)|ensembl:ENST00000395942(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0060326"(cell chemotaxis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002238(C-C chemokine receptor, type 3)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-380108|reactome:R-HSA-418594|ensembl:ENST00000357422(transcript)|refseq:XP_011531637.1|refseq:NP_001828.1|refseq:NP_847899.1|refseq:NP_847898.1|refseq:XP_006713023.1|dip:DIP-5846N	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	-	-	-	figure legend:Table S2-51|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.5x10^-9(molar)	2013/04/23	2014/10/16	rogid:kDi5hBQAA6JsNVK1e6ZlG89jGsM9606	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	intact-crc:C0248049A35A8918|rigid:YGd0LHYu4Zwh2FKHF8nxLXsA4AA	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P51677	uniprotkb:P51671	intact:EBI-6625120|ensembl:ENSP00000350003|ensembl:ENSP00000379271|ensembl:ENSP00000379273|uniprotkb:B3KVQ1|uniprotkb:Q15748|uniprotkb:Q2YDB9|uniprotkb:Q86WD2|uniprotkb:Q9ULY8|uniprotkb:F5GWL6|uniprotkb:Q8TDP6	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	psi-mi:ccr3_human(display_long)|uniprotkb:CCR3(gene name)|psi-mi:CCR3(display_short)|uniprotkb:CMKBR3(gene name synonym)|uniprotkb:Eosinophil eotaxin receptor(gene name synonym)	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6625054|imex:IM-20536-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183625(gene)|ensembl:ENST00000395940(transcript)|ensembl:ENST00000395942(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0060326"(cell chemotaxis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002238(C-C chemokine receptor, type 3)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-380108|reactome:R-HSA-418594|ensembl:ENST00000357422(transcript)|refseq:XP_011531637.1|refseq:NP_001828.1|refseq:NP_847899.1|refseq:NP_847898.1|refseq:XP_006713023.1|dip:DIP-5846N	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	-	-	-	figure legend:Table S2-51|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.5x10^-9(molar)	2013/04/23	2014/10/16	rogid:kDi5hBQAA6JsNVK1e6ZlG89jGsM9606	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	intact-crc:C0248049A35A8918|rigid:YGd0LHYu4Zwh2FKHF8nxLXsA4AA	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P47211	uniprotkb:P22466-PRO_0000010449	intact:EBI-6624741|ensembl:ENSP00000299727|uniprotkb:Q4VBL7	intact:EBI-6624800	psi-mi:galr1_human(display_long)|uniprotkb:GALR1(gene name)|psi-mi:GALR1(display_short)|uniprotkb:GALNR(gene name synonym)|uniprotkb:GALNR1(gene name synonym)	psi-mi:p22466-pro_0000010449(display_long)|uniprotkb:GAL(gene name)|psi-mi:GAL(display_short)|uniprotkb:GAL1(gene name synonym)|uniprotkb:GALN(gene name synonym)|uniprotkb:GLNN(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624733|imex:IM-20536-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166573(gene)|ensembl:ENST00000299727(transcript)|go:"GO:0004966"(galanin receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051464"(positive regulation of cortisol secretion)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000405(Galanin receptor)|interpro:IPR003906(Galanin 1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_001471.2	intact:EBI-6624768(chain-parent)	-	-	chain-seq-start:33|chain-seq-end:62	figure legend:Table S2-41|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.24x10^-9(molar)	2013/04/23	2014/10/16	rogid:2cyPncH8b79+lmM6piQTdEAS3h89606	rogid:Ap3LftulUqpof4tpDP+DuCa2Kiw9606	intact-crc:8CBD14A7AE702A0F|rigid:ftuxRv5JkNp8cGEwUHMeFxi0+Fc	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P47211	uniprotkb:P22466-PRO_0000010449	intact:EBI-6624741|ensembl:ENSP00000299727|uniprotkb:Q4VBL7	intact:EBI-6624800	psi-mi:galr1_human(display_long)|uniprotkb:GALR1(gene name)|psi-mi:GALR1(display_short)|uniprotkb:GALNR(gene name synonym)|uniprotkb:GALNR1(gene name synonym)	psi-mi:p22466-pro_0000010449(display_long)|uniprotkb:GAL(gene name)|psi-mi:GAL(display_short)|uniprotkb:GAL1(gene name synonym)|uniprotkb:GALN(gene name synonym)|uniprotkb:GLNN(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624733|imex:IM-20536-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166573(gene)|ensembl:ENST00000299727(transcript)|go:"GO:0004966"(galanin receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051464"(positive regulation of cortisol secretion)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000405(Galanin receptor)|interpro:IPR003906(Galanin 1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_001471.2	intact:EBI-6624768(chain-parent)	-	-	chain-seq-start:33|chain-seq-end:62	figure legend:Table S2-41|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.24x10^-9(molar)	2013/04/23	2014/10/16	rogid:2cyPncH8b79+lmM6piQTdEAS3h89606	rogid:Ap3LftulUqpof4tpDP+DuCa2Kiw9606	intact-crc:8CBD14A7AE702A0F|rigid:ftuxRv5JkNp8cGEwUHMeFxi0+Fc	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:64093"	uniprotkb:Q01959	intact:EBI-6661491	intact:EBI-6661445|ensembl:ENSP00000270349|ensembl:ENSP00000479597|uniprotkb:A2RUN4|uniprotkb:Q14996	psi-mi:gbr12935(display_short)|psi-mi:"CHEBI:64093"(display_long)	psi-mi:sc6a3_human(display_long)|uniprotkb:SLC6A3(gene name)|psi-mi:SLC6A3(display_short)|uniprotkb:DAT1(gene name synonym)|uniprotkb:Solute carrier family 6 member 3(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6661434|imex:IM-20536-124	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0015844"(monoamine transport)|go:"GO:0015872"(dopamine transport)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015874"(norepinephrine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0009986"(cell surface)|go:"GO:0016600"(flotillin complex)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0030424"(axon)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0035094"(response to nicotine)|go:"GO:0035240"(dopamine binding)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042420"(dopamine catabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051591"(response to cAMP)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0090494"(dopamine uptake)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0010039"(response to iron ion)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1990384"(hyaloid vascular plexus regression)|interpro:IPR000175("Sodium:neurotransmitter symporter")|interpro:IPR002436("Sodium:neurotransmitter symporter, dopamine")|interpro:IPR037272|mint:Q01959|reactome:R-HSA-379401|reactome:R-HSA-442660|reactome:R-HSA-5619081|reactome:R-HSA-5660724|ensembl:ENSG00000142319(gene)|ensembl:ENSG00000276996(gene)|ensembl:ENST00000270349(transcript)|ensembl:ENST00000621716(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005330"("dopamine:sodium symporter activity")|go:"GO:0005334"("norepinephrine:sodium symporter activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007568"(aging)|go:"GO:0007595"(lactation)|go:"GO:0007608"(sensory perception of smell)|refseq:NP_001035.1|dip:DIP-41827N	-	-	-	figure legend:Table S2-122|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:22.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:mQKSGpeovNv4Sg8T2E3A8rVB2aY9606	intact-crc:9FCE02ACD07AC31A	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:64089"	uniprotkb:Q01959	intact:EBI-6661493	intact:EBI-6661445|ensembl:ENSP00000270349|ensembl:ENSP00000479597|uniprotkb:A2RUN4|uniprotkb:Q14996	psi-mi:gbr12909-vanoxerine(display_short)|psi-mi:"CHEBI:64089"(display_long)	psi-mi:sc6a3_human(display_long)|uniprotkb:SLC6A3(gene name)|psi-mi:SLC6A3(display_short)|uniprotkb:DAT1(gene name synonym)|uniprotkb:Solute carrier family 6 member 3(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6661434|imex:IM-20536-124	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0015844"(monoamine transport)|go:"GO:0015872"(dopamine transport)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015874"(norepinephrine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0009986"(cell surface)|go:"GO:0016600"(flotillin complex)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0030424"(axon)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0035094"(response to nicotine)|go:"GO:0035240"(dopamine binding)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042420"(dopamine catabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051591"(response to cAMP)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0090494"(dopamine uptake)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0010039"(response to iron ion)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1990384"(hyaloid vascular plexus regression)|interpro:IPR000175("Sodium:neurotransmitter symporter")|interpro:IPR002436("Sodium:neurotransmitter symporter, dopamine")|interpro:IPR037272|mint:Q01959|reactome:R-HSA-379401|reactome:R-HSA-442660|reactome:R-HSA-5619081|reactome:R-HSA-5660724|ensembl:ENSG00000142319(gene)|ensembl:ENSG00000276996(gene)|ensembl:ENST00000270349(transcript)|ensembl:ENST00000621716(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005330"("dopamine:sodium symporter activity")|go:"GO:0005334"("norepinephrine:sodium symporter activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007568"(aging)|go:"GO:0007595"(lactation)|go:"GO:0007608"(sensory perception of smell)|refseq:NP_001035.1|dip:DIP-41827N	-	-	-	figure legend:Table S2-122|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:22.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:mQKSGpeovNv4Sg8T2E3A8rVB2aY9606	intact-crc:9FCE02ACD07AC31A	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73339"	uniprotkb:P08172	intact:EBI-6655180	intact:EBI-2624832|uniprotkb:Q4VBK6|uniprotkb:Q9P1X9|ensembl:ENSP00000319984|ensembl:ENSP00000384401|ensembl:ENSP00000399745|ensembl:ENSP00000415386|ensembl:ENSP00000505686	psi-mi:methoctramine(display_short)|psi-mi:"CHEBI:73339"(display_long)	psi-mi:acm2_human(display_long)|uniprotkb:CHRM2(gene name)|psi-mi:CHRM2(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655169|imex:IM-20536-88	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011514071.1|refseq:NP_000730.1|refseq:NP_001006627.1|refseq:NP_001006628.1|refseq:NP_001006629.1|refseq:NP_001006630.1|refseq:NP_001006631.1|refseq:NP_001006632.1|refseq:NP_001006633.1|ensembl:ENSG00000181072(gene)|ensembl:ENST00000320658(transcript)|ensembl:ENST00000401861(transcript)|ensembl:ENST00000445907(transcript)|ensembl:ENST00000453373(transcript)|ensembl:ENST00000680005(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009615"(response to virus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001065(Muscarinic acetylcholine receptor M2)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LUB|rcsb pdb:3UON|rcsb pdb:4MQS|rcsb pdb:4MQT|rcsb pdb:5YC8|rcsb pdb:5ZK3|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|rcsb pdb:5ZKB|rcsb pdb:5ZKC|rcsb pdb:6OIK|rcsb pdb:6U1N|reactome:R-HSA-390648|reactome:R-HSA-418594|reactome:R-HSA-8856825|reactome:R-HSA-8856828|rcsb pdb:5ZK8|dip:DIP-56282N	-	-	-	figure legend:Table S2-63|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:22.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:Rg7s3/iAh4+DTvkasK8G/BWc+yM9606	intact-crc:ACC751315285B528	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73338"	uniprotkb:P08172	intact:EBI-6655177	intact:EBI-2624832|uniprotkb:Q4VBK6|uniprotkb:Q9P1X9|ensembl:ENSP00000319984|ensembl:ENSP00000384401|ensembl:ENSP00000399745|ensembl:ENSP00000415386|ensembl:ENSP00000505686	psi-mi:af-dx 384(display_short)|psi-mi:"CHEBI:73338"(display_long)	psi-mi:acm2_human(display_long)|uniprotkb:CHRM2(gene name)|psi-mi:CHRM2(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655169|imex:IM-20536-88	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011514071.1|refseq:NP_000730.1|refseq:NP_001006627.1|refseq:NP_001006628.1|refseq:NP_001006629.1|refseq:NP_001006630.1|refseq:NP_001006631.1|refseq:NP_001006632.1|refseq:NP_001006633.1|ensembl:ENSG00000181072(gene)|ensembl:ENST00000320658(transcript)|ensembl:ENST00000401861(transcript)|ensembl:ENST00000445907(transcript)|ensembl:ENST00000453373(transcript)|ensembl:ENST00000680005(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009615"(response to virus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001065(Muscarinic acetylcholine receptor M2)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LUB|rcsb pdb:3UON|rcsb pdb:4MQS|rcsb pdb:4MQT|rcsb pdb:5YC8|rcsb pdb:5ZK3|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|rcsb pdb:5ZKB|rcsb pdb:5ZKC|rcsb pdb:6OIK|rcsb pdb:6U1N|reactome:R-HSA-390648|reactome:R-HSA-418594|reactome:R-HSA-8856825|reactome:R-HSA-8856828|rcsb pdb:5ZK8|dip:DIP-56282N	-	-	-	figure legend:Table S2-63|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:22.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:Rg7s3/iAh4+DTvkasK8G/BWc+yM9606	intact-crc:ACC751315285B528	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73340"	uniprotkb:P20309	intact:EBI-6655199	intact:EBI-2687785|uniprotkb:Q0VAJ8|uniprotkb:Q9HB60|uniprotkb:Q4QRI3|uniprotkb:Q5VXY2|ensembl:ENSP00000255380|ensembl:ENSP00000482377|ensembl:ENSP00000502013|ensembl:ENSP00000502349|ensembl:ENSP00000502667	psi-mi:4-damp(display_short)|psi-mi:"CHEBI:73340"(display_long)	psi-mi:acm3_human(display_long)|uniprotkb:CHRM3(gene name)|psi-mi:CHRM3(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655190|imex:IM-20536-90	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011542343.1|refseq:XP_011542345.1|refseq:XP_011542346.1|refseq:XP_011542348.1|refseq:XP_011542349.1|refseq:NP_000731.1|refseq:NP_001334645.1|refseq:XP_005273089.1|ensembl:ENSG00000133019(gene)|ensembl:ENST00000255380(transcript)|ensembl:ENST00000615928(transcript)|ensembl:ENST00000675184(transcript)|ensembl:ENST00000676433(transcript)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|ensembl:ENST00000676153(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032412"(regulation of ion transmembrane transporter activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046541"(saliva secretion)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001183(Muscarinic acetylcholine receptor M3)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P20309|rcsb pdb:2CSA|reactome:R-HSA-390648|reactome:R-HSA-399997|reactome:R-HSA-416476|refseq:XP_016855641.1|refseq:XP_016855642.1|refseq:XP_016855643.1|refseq:XP_016855644.1|refseq:XP_016855645.1|refseq:XP_016855646.1|refseq:XP_016855647.1|refseq:XP_016855648.1|refseq:XP_016855649.1|refseq:XP_016855650.1|refseq:XP_016855651.1|refseq:XP_016855652.1|dip:DIP-44291N	-	-	-	figure legend:Table S2-65|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.5x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:/arNBsrkXe4KcqIqBw4BEwYZHt49606	intact-crc:7ACE7DBDCBADFFC5	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73340"	uniprotkb:P20309	intact:EBI-6655199	intact:EBI-2687785|uniprotkb:Q0VAJ8|uniprotkb:Q9HB60|uniprotkb:Q4QRI3|uniprotkb:Q5VXY2|ensembl:ENSP00000255380|ensembl:ENSP00000482377|ensembl:ENSP00000502013|ensembl:ENSP00000502349|ensembl:ENSP00000502667	psi-mi:4-damp(display_short)|psi-mi:"CHEBI:73340"(display_long)	psi-mi:acm3_human(display_long)|uniprotkb:CHRM3(gene name)|psi-mi:CHRM3(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655190|imex:IM-20536-90	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011542343.1|refseq:XP_011542345.1|refseq:XP_011542346.1|refseq:XP_011542348.1|refseq:XP_011542349.1|refseq:NP_000731.1|refseq:NP_001334645.1|refseq:XP_005273089.1|ensembl:ENSG00000133019(gene)|ensembl:ENST00000255380(transcript)|ensembl:ENST00000615928(transcript)|ensembl:ENST00000675184(transcript)|ensembl:ENST00000676433(transcript)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|ensembl:ENST00000676153(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032412"(regulation of ion transmembrane transporter activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046541"(saliva secretion)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001183(Muscarinic acetylcholine receptor M3)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P20309|rcsb pdb:2CSA|reactome:R-HSA-390648|reactome:R-HSA-399997|reactome:R-HSA-416476|refseq:XP_016855641.1|refseq:XP_016855642.1|refseq:XP_016855643.1|refseq:XP_016855644.1|refseq:XP_016855645.1|refseq:XP_016855646.1|refseq:XP_016855647.1|refseq:XP_016855648.1|refseq:XP_016855649.1|refseq:XP_016855650.1|refseq:XP_016855651.1|refseq:XP_016855652.1|dip:DIP-44291N	-	-	-	figure legend:Table S2-65|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.5x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:/arNBsrkXe4KcqIqBw4BEwYZHt49606	intact-crc:7ACE7DBDCBADFFC5	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73378"	uniprotkb:P28335	intact:EBI-6656400	intact:EBI-994141|uniprotkb:Q5VUF8|uniprotkb:Q9NP28|ensembl:ENSP00000276198|ensembl:ENSP00000361018|ensembl:ENSP00000361019|uniprotkb:B1AMW4	psi-mi:mesulergine(display_short)|psi-mi:"CHEBI:73378"(display_long)	psi-mi:5ht2c_human(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656392|imex:IM-20536-105	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000859.1|ensembl:ENSG00000147246(gene)|ensembl:ENST00000276198(transcript)|ensembl:ENST00000371950(transcript)|ensembl:ENST00000371951(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P28335|rcsb pdb:6BQG|rcsb pdb:6BQH|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|refseq:NP_001243690.1|refseq:NP_001243689.1	-	-	-	figure legend:Table S2-97|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:4.1x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	intact-crc:D8238B1667845454	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73378"	uniprotkb:P28335	intact:EBI-6656400	intact:EBI-994141|uniprotkb:Q5VUF8|uniprotkb:Q9NP28|ensembl:ENSP00000276198|ensembl:ENSP00000361018|ensembl:ENSP00000361019|uniprotkb:B1AMW4	psi-mi:mesulergine(display_short)|psi-mi:"CHEBI:73378"(display_long)	psi-mi:5ht2c_human(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656392|imex:IM-20536-105	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000859.1|ensembl:ENSG00000147246(gene)|ensembl:ENST00000276198(transcript)|ensembl:ENST00000371950(transcript)|ensembl:ENST00000371951(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P28335|rcsb pdb:6BQG|rcsb pdb:6BQH|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|refseq:NP_001243690.1|refseq:NP_001243689.1	-	-	-	figure legend:Table S2-97|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:4.1x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	intact-crc:D8238B1667845454	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73472"	uniprotkb:P27338	intact:EBI-6662560	intact:EBI-3911344|uniprotkb:B7Z5H3|uniprotkb:B2R6R3|uniprotkb:D3DWC3|uniprotkb:Q7Z6S2|ensembl:ENSP00000367309	psi-mi:kynuramine(display_short)|psi-mi:"CHEBI:73472"(display_long)	psi-mi:aofb_human(display_long)|uniprotkb:MAOB(gene name)|psi-mi:MAOB(display_short)|uniprotkb:Monoamine oxidase type B(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662578|imex:IM-20536-140	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000889.3|ensembl:ENSG00000069535(gene)|ensembl:ENST00000378069(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0010269"(response to selenium ion)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042135"(neurotransmitter catabolic process)|go:"GO:0042420"(dopamine catabolic process)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045964"(positive regulation of dopamine metabolic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0051412"(response to corticosterone)|go:"GO:0097621"(monoamine oxidase activity)|interpro:IPR001613(Flavin-containing amine oxidase)|interpro:IPR002937(Amine oxidase)|interpro:IPR036188|rcsb pdb:1GOS|rcsb pdb:1H8R|rcsb pdb:1OJ9|rcsb pdb:1OJA|rcsb pdb:1OJC|rcsb pdb:1OJD|rcsb pdb:1S2Q|rcsb pdb:1S2Y|rcsb pdb:1S3B|rcsb pdb:1S3E|rcsb pdb:2BK3|rcsb pdb:2BK4|rcsb pdb:2BK5|rcsb pdb:2BYB|rcsb pdb:2C64|rcsb pdb:2C65|rcsb pdb:2C66|rcsb pdb:2C67|rcsb pdb:2C70|rcsb pdb:2C72|rcsb pdb:2C73|rcsb pdb:2C75|rcsb pdb:2C76|rcsb pdb:2V5Z|rcsb pdb:2V60|rcsb pdb:2V61|rcsb pdb:2VRL|rcsb pdb:2VRM|rcsb pdb:2VZ2|rcsb pdb:2XCG|rcsb pdb:2XFN|rcsb pdb:2XFO|rcsb pdb:2XFP|rcsb pdb:2XFQ|rcsb pdb:2XFU|rcsb pdb:3PO7|rcsb pdb:3ZYX|rcsb pdb:4A79|rcsb pdb:4A7A|rcsb pdb:4CRT|rcsb pdb:5MRL|rcsb pdb:6FVZ|rcsb pdb:6FW0|rcsb pdb:6FWC|rcsb pdb:6RKB|rcsb pdb:6RKP|rcsb pdb:6RLE|rcsb pdb:6YT2|reactome:R-HSA-141333	-	-	-	figure legend:Table S2-137|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:IDk70w0RMI8dOb65dcgbrDYzSw09606	intact-crc:9D98DAEF2FE2F808	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:15843"	uniprotkb:P09917	intact:EBI-6662097	intact:EBI-79934|ensembl:ENSP00000363512|ensembl:ENSP00000484468|uniprotkb:Q5JQ14|uniprotkb:E5FPY5|uniprotkb:E5FPY7|uniprotkb:E5FPY8|uniprotkb:B7ZLS0	psi-mi:arachidonic acid(display_short)|psi-mi:"CHEBI:15843"(display_long)	psi-mi:lox5_human(display_long)|uniprotkb:ALOX5(gene name)|psi-mi:ALOX5(display_short)|uniprotkb:LOG5(gene name synonym)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662212|imex:IM-20536-133	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000012779(gene)|ensembl:ENSG00000275565(gene)|ensembl:ENST00000374391(transcript)|ensembl:ENST00000610656(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0005615"(extracellular space)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0005635"(nuclear envelope)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:0016787"(hydrolase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABV|rcsb pdb:3O8Y|rcsb pdb:3V92|rcsb pdb:3V98|rcsb pdb:3V99|rcsb pdb:6N2W|rcsb pdb:6NCF|reactome:R-HSA-2142688|reactome:R-HSA-2142691|reactome:R-HSA-2142700|go:"GO:0019369"(arachidonic acid metabolic process)|reactome:R-HSA-6785807|reactome:R-HSA-9023661|reactome:R-HSA-9026286|reactome:R-HSA-9026290|reactome:R-HSA-9026403|reactome:R-HSA-9027604|reactome:R-HSA-6798695|reactome:R-HSA-9012546|reactome:R-HSA-9018676|reactome:R-HSA-9018682|reactome:R-HSA-9018896|reactome:R-HSA-9020265|refseq:NP_000689.1|refseq:NP_001307790.1|dip:DIP-30950N|refseq:NP_001243082.1|refseq:NP_001243083.1	-	-	-	figure legend:Table S2-131|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:kk3yqgz7R/Po68UpJpKJ3Rp6Ws89606	intact-crc:836BF8FA2EA4C235	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:50114"	uniprotkb:P03372	intact:EBI-6656748	intact:EBI-78473|uniprotkb:Q6MZQ9|ensembl:ENSP00000387500|ensembl:ENSP00000342630|ensembl:ENSP00000206249|ensembl:ENSP00000405330|uniprotkb:Q13511|uniprotkb:Q14276|uniprotkb:Q9NU51|uniprotkb:Q9UDZ7|uniprotkb:Q9UIS7|intact:EBI-28988800|uniprotkb:Q5T5H7	psi-mi:fluormone- es2(display_short)|psi-mi:"CHEBI:50114"(display_long)	psi-mi:esr1_human(display_long)|uniprotkb:ESR1(gene name)|psi-mi:ESR1(display_short)|uniprotkb:ESR(gene name synonym)|uniprotkb:NR3A1(gene name synonym)|uniprotkb:Estradiol receptor(gene name synonym)|uniprotkb:ER-alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group A member 1(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656772|imex:IM-20536-118	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000091831(gene)|ensembl:ENST00000206249(transcript)|ensembl:ENST00000338799(transcript)|ensembl:ENST00000440973(transcript)|ensembl:ENST00000443427(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_000116.2|refseq:NP_001116212.1|refseq:NP_001116213.1|refseq:NP_001116214.1|refseq:XP_011533845.1|refseq:XP_011533846.1|refseq:XP_011533847.1|refseq:XP_006715438.1|ensembl:ENSP00000206249|ensembl:ENSP00000342630|ensembl:ENSP00000405330|ensembl:ENSP00000387500|refseq:NP_001278159.1|refseq:NP_001278170.1|refseq:NP_001315029.1|refseq:XP_016865865.1|refseq:XP_016865866.1|refseq:XP_016865867.1|refseq:XP_016865868.1|refseq:XP_016865869.1|refseq:XP_016865870.1|dip:DIP-5965N|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0002064"(epithelial cell development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030284"(estrogen receptor activity)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034056"(estrogen response element binding)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035327"|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060065"(uterus development)|go:"GO:0060068"(vagina development)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001292(Oestrogen receptor, AF1 modulatory)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR024736|interpro:IPR035500|mint:P03372|rcsb pdb:1A52|rcsb pdb:1AKF|rcsb pdb:1ERE|rcsb pdb:1ERR|rcsb pdb:1G50|rcsb pdb:1GWQ|rcsb pdb:1GWR|rcsb pdb:1HCP|rcsb pdb:1HCQ|rcsb pdb:1L2I|rcsb pdb:1PCG|rcsb pdb:1QKT|rcsb pdb:1QKU|rcsb pdb:1R5K|rcsb pdb:1SJ0|rcsb pdb:1UOM|rcsb pdb:1X7E|rcsb pdb:1X7R|rcsb pdb:1XP1|rcsb pdb:1XP6|rcsb pdb:1XP9|rcsb pdb:1XPC|rcsb pdb:1XQC|rcsb pdb:1YIM|rcsb pdb:1YIN|rcsb pdb:1ZKY|rcsb pdb:2AYR|rcsb pdb:2B1V|rcsb pdb:2B1Z|rcsb pdb:2B23|rcsb pdb:2BJ4|rcsb pdb:2FAI|rcsb pdb:2G44|rcsb pdb:2G5O|rcsb pdb:2I0J|rcsb pdb:2IOG|rcsb pdb:2IOK|rcsb pdb:2JF9|rcsb pdb:2JFA|rcsb pdb:2LLO|rcsb pdb:2LLQ|rcsb pdb:2OCF|rcsb pdb:2OUZ|rcsb pdb:2P15|rcsb pdb:2POG|rcsb pdb:2Q6J|rcsb pdb:2Q70|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QE4|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QXS|rcsb pdb:2QZO|rcsb pdb:2R6W|rcsb pdb:2R6Y|rcsb pdb:2YAT|rcsb pdb:2YJA|rcsb pdb:3DT3|rcsb pdb:3ERD|rcsb pdb:3ERT|rcsb pdb:3HLV|rcsb pdb:3HM1|rcsb pdb:3L03|rcsb pdb:3OS8|rcsb pdb:3OS9|rcsb pdb:3OSA|rcsb pdb:3Q95|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUC|rcsb pdb:3UUD|rcsb pdb:4AA6|rcsb pdb:4DMA|rcsb pdb:4IU7|rcsb pdb:4IUI|rcsb pdb:4IV2|rcsb pdb:4IV4|rcsb pdb:4IVW|rcsb pdb:4IVY|rcsb pdb:4IW6|rcsb pdb:4IW8|rcsb pdb:4IWC|rcsb pdb:4IWF|rcsb pdb:4JC3|rcsb pdb:4JDD|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4O6F|rcsb pdb:4PP6|rcsb pdb:4PPP|rcsb pdb:4PPS|rcsb pdb:4PXM|rcsb pdb:4Q13|rcsb pdb:4Q50|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4XI3|rcsb pdb:4ZN7|rcsb pdb:4ZN9|rcsb pdb:4ZNH|rcsb pdb:4ZNS|rcsb pdb:4ZNT|rcsb pdb:4ZNU|rcsb pdb:4ZNV|rcsb pdb:4ZNW|rcsb pdb:5AAU|rcsb pdb:5AAV|rcsb pdb:5ACC|rcsb pdb:5AK2|rcsb pdb:5DI7|rcsb pdb:5DID|rcsb pdb:5DIE|rcsb pdb:5DIG|rcsb pdb:5DK9|rcsb pdb:5DKB|rcsb pdb:5DKE|rcsb pdb:5DKG|rcsb pdb:5DKS|rcsb pdb:5DL4|rcsb pdb:5DLR|rcsb pdb:5DMC|rcsb pdb:5DMF|rcsb pdb:5DP0|rcsb pdb:5DRJ|rcsb pdb:5DRM|rcsb pdb:5DTV|rcsb pdb:5DU5|rcsb pdb:5DUE|rcsb pdb:5DUG|rcsb pdb:5DUH|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:5DVS|rcsb pdb:5DVV|rcsb pdb:5DWE|rcsb pdb:5DWG|rcsb pdb:5DWI|rcsb pdb:5DWJ|rcsb pdb:5DX3|rcsb pdb:5DXB|rcsb pdb:5DXE|rcsb pdb:5DXG|rcsb pdb:5DXK|rcsb pdb:5DXM|rcsb pdb:5DXQ|rcsb pdb:5DXR|rcsb pdb:5DY8|rcsb pdb:5DYB|rcsb pdb:5DYD|rcsb pdb:5DZ0|rcsb pdb:5DZ1|rcsb pdb:5DZ3|rcsb pdb:5DZH|rcsb pdb:5DZI|rcsb pdb:5E0W|rcsb pdb:5E0X|rcsb pdb:5E14|rcsb pdb:5E15|rcsb pdb:5E19|rcsb pdb:5E1C|rcsb pdb:5EGV|rcsb pdb:5EHJ|rcsb pdb:5EI1|rcsb pdb:5EIT|rcsb pdb:5FQP|rcsb pdb:5FQR|rcsb pdb:5FQS|rcsb pdb:5FQT|rcsb pdb:5FQV|rcsb pdb:5GS4|rcsb pdb:5GTR|rcsb pdb:5HYR|rcsb pdb:5JMM|rcsb pdb:5KCC|rcsb pdb:5KCD|rcsb pdb:5KCE|rcsb pdb:5KCF|rcsb pdb:5KCT|rcsb pdb:5KCU|rcsb pdb:5KCW|rcsb pdb:5KD9|rcsb pdb:5KR9|rcsb pdb:5KRA|rcsb pdb:5KRC|rcsb pdb:5KRF|rcsb pdb:5KRH|rcsb pdb:5KRI|rcsb pdb:5KRJ|rcsb pdb:5KRK|rcsb pdb:5KRL|rcsb pdb:5KRM|rcsb pdb:5KRO|rcsb pdb:5N10|rcsb pdb:5T0X|rcsb pdb:5T1Z|rcsb pdb:5T92|rcsb pdb:5T97|rcsb pdb:5TLD|rcsb pdb:5TLF|rcsb pdb:5TLG|rcsb pdb:5TLL|rcsb pdb:5TLM|rcsb pdb:5TLO|rcsb pdb:5TLP|rcsb pdb:5TLT|rcsb pdb:5TLU|rcsb pdb:5TLV|rcsb pdb:5TLX|rcsb pdb:5TLY|rcsb pdb:5TM1|rcsb pdb:5TM2|rcsb pdb:5TM3|rcsb pdb:5TM4|rcsb pdb:5TM5|rcsb pdb:5TM6|rcsb pdb:5TM7|rcsb pdb:5TM8|rcsb pdb:5TM9|rcsb pdb:5TML|rcsb pdb:5TMM|rcsb pdb:5TMO|rcsb pdb:5TMQ|rcsb pdb:5TMR|rcsb pdb:5TMS|rcsb pdb:5TMT|rcsb pdb:5TMU|rcsb pdb:5TMV|rcsb pdb:5TMW|rcsb pdb:5TMZ|rcsb pdb:5TN1|rcsb pdb:5TN3|rcsb pdb:5TN4|rcsb pdb:5TN5|rcsb pdb:5TN6|rcsb pdb:5TN7|rcsb pdb:5TN8|rcsb pdb:5TN9|rcsb pdb:5TNB|rcsb pdb:5U2B|rcsb pdb:5U2D|rcsb pdb:5UFW|rcsb pdb:5DXP|rcsb pdb:5UFX|rcsb pdb:5W9C|rcsb pdb:5W9D|rcsb pdb:5WGD|rcsb pdb:5WGQ|rcsb pdb:6B0F|rcsb pdb:6C42|rcsb pdb:6CBZ|rcsb pdb:6CHW|rcsb pdb:6CHZ|rcsb pdb:6CZN|rcsb pdb:6D0F|rcsb pdb:6DF6|rcsb pdb:6DFN|rcsb pdb:6HHP|rcsb pdb:6HKF|rcsb pdb:6HMU|rcsb pdb:6IAR|rcsb pdb:6OWC|rcsb pdb:6PET|rcsb pdb:6PFM|rcsb pdb:6PIT|rcsb pdb:6PSJ|rcsb pdb:6SBO|rcsb pdb:6SQ0|rcsb pdb:6SUO|rcsb pdb:6TJM|rcsb pdb:6TL3|rcsb pdb:6V87|rcsb pdb:6V8T|rcsb pdb:6VGH|rcsb pdb:6VIG|rcsb pdb:6VJ1|rcsb pdb:6VJD|rcsb pdb:6VMU|rcsb pdb:6VPF|rcsb pdb:6VPK|rcsb pdb:6VVP|rcsb pdb:6WOK|rcsb pdb:6ZOQ|rcsb pdb:6ZOR|rcsb pdb:6ZOS|rcsb pdb:7JHD|rcsb pdb:7KBS|rcsb pdb:7KCA|rcsb pdb:7KCD|rcsb pdb:7MSA|rcsb pdb:7NFW|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5689896|reactome:R-HSA-6811558|reactome:R-HSA-8866910|reactome:R-HSA-8931987|reactome:R-HSA-8939211|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-9009391|reactome:R-HSA-9018519|rcsb pdb:6HKB	-	-	-	figure legend:Table S2-109|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:T8sQVUNhd5AfJXfL0mjq9TA/C/o9606	intact-crc:034C9120621CCDAE	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73410"	uniprotkb:P23975	intact:EBI-6661417	intact:EBI-6661391|ensembl:ENSP00000369237|ensembl:ENSP00000457473|uniprotkb:B2R707|uniprotkb:Q96KH8|uniprotkb:B4DX48	psi-mi:nisoxetine(display_short)|psi-mi:"CHEBI:73410"(display_long)	psi-mi:sc6a2_human(display_long)|uniprotkb:SLC6A2(gene name)|psi-mi:SLC6A2(display_short)|uniprotkb:NAT1(gene name synonym)|uniprotkb:NET1(gene name synonym)|uniprotkb:SLC6A5(gene name synonym)|uniprotkb:Norepinephrine transporter(gene name synonym)|uniprotkb:Solute carrier family 6 member 2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656930|imex:IM-20536-122	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000103546(gene)|ensembl:ENST00000379906(transcript)|ensembl:ENST00000568943(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005328"("neurotransmitter:sodium symporter activity")|go:"GO:0005330"("dopamine:sodium symporter activity")|go:"GO:0005334"("norepinephrine:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0009986"(cell surface)|go:"GO:0015844"(monoamine transport)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0048265"(response to pain)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051620"(norepinephrine uptake)|go:"GO:0070050"(neuron cellular homeostasis)|interpro:IPR000175("Sodium:neurotransmitter symporter")|interpro:IPR002435("Sodium:neurotransmitter symporter, noradrenaline")|interpro:IPR037272|reactome:R-HSA-442660|reactome:R-HSA-5619109|go:"GO:0015874"(norepinephrine transport)|go:"GO:0016020"(membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|refseq:XP_011521597.1|refseq:NP_001034.1|refseq:NP_001165972.1|refseq:NP_001165975.1|refseq:NP_001165973.1|refseq:XP_006721326.1	-	-	-	figure legend:Table S2-120|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:hehF0DnHCYX/ZiRKE7nzQBciHyA9606	intact-crc:4118ECED7E867012	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:8597"	uniprotkb:P23975	intact:EBI-6661423	intact:EBI-6661391|ensembl:ENSP00000369237|ensembl:ENSP00000457473|uniprotkb:B2R707|uniprotkb:Q96KH8|uniprotkb:B4DX48	psi-mi:protriptyline(display_short)|psi-mi:"CHEBI:8597"(display_long)	psi-mi:sc6a2_human(display_long)|uniprotkb:SLC6A2(gene name)|psi-mi:SLC6A2(display_short)|uniprotkb:NAT1(gene name synonym)|uniprotkb:NET1(gene name synonym)|uniprotkb:SLC6A5(gene name synonym)|uniprotkb:Norepinephrine transporter(gene name synonym)|uniprotkb:Solute carrier family 6 member 2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656930|imex:IM-20536-122	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000103546(gene)|ensembl:ENST00000379906(transcript)|ensembl:ENST00000568943(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005328"("neurotransmitter:sodium symporter activity")|go:"GO:0005330"("dopamine:sodium symporter activity")|go:"GO:0005334"("norepinephrine:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0009986"(cell surface)|go:"GO:0015844"(monoamine transport)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0048265"(response to pain)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051620"(norepinephrine uptake)|go:"GO:0070050"(neuron cellular homeostasis)|interpro:IPR000175("Sodium:neurotransmitter symporter")|interpro:IPR002435("Sodium:neurotransmitter symporter, noradrenaline")|interpro:IPR037272|reactome:R-HSA-442660|reactome:R-HSA-5619109|go:"GO:0015874"(norepinephrine transport)|go:"GO:0016020"(membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0035725"(sodium ion transmembrane transport)|refseq:XP_011521597.1|refseq:NP_001034.1|refseq:NP_001165972.1|refseq:NP_001165975.1|refseq:NP_001165973.1|refseq:XP_006721326.1	-	-	-	figure legend:Table S2-120|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:hehF0DnHCYX/ZiRKE7nzQBciHyA9606	intact-crc:4118ECED7E867012	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73340"	uniprotkb:P20309	intact:EBI-6655199	intact:EBI-2687785|uniprotkb:Q0VAJ8|uniprotkb:Q9HB60|uniprotkb:Q4QRI3|uniprotkb:Q5VXY2|ensembl:ENSP00000255380|ensembl:ENSP00000482377|ensembl:ENSP00000502013|ensembl:ENSP00000502349|ensembl:ENSP00000502667	psi-mi:4-damp(display_short)|psi-mi:"CHEBI:73340"(display_long)	psi-mi:acm3_human(display_long)|uniprotkb:CHRM3(gene name)|psi-mi:CHRM3(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655201|imex:IM-20536-91	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011542343.1|refseq:XP_011542345.1|refseq:XP_011542346.1|refseq:XP_011542348.1|refseq:XP_011542349.1|refseq:NP_000731.1|refseq:NP_001334645.1|refseq:XP_005273089.1|ensembl:ENSG00000133019(gene)|ensembl:ENST00000255380(transcript)|ensembl:ENST00000615928(transcript)|ensembl:ENST00000675184(transcript)|ensembl:ENST00000676433(transcript)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|ensembl:ENST00000676153(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032412"(regulation of ion transmembrane transporter activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046541"(saliva secretion)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001183(Muscarinic acetylcholine receptor M3)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P20309|rcsb pdb:2CSA|reactome:R-HSA-390648|reactome:R-HSA-399997|reactome:R-HSA-416476|refseq:XP_016855641.1|refseq:XP_016855642.1|refseq:XP_016855643.1|refseq:XP_016855644.1|refseq:XP_016855645.1|refseq:XP_016855646.1|refseq:XP_016855647.1|refseq:XP_016855648.1|refseq:XP_016855649.1|refseq:XP_016855650.1|refseq:XP_016855651.1|refseq:XP_016855652.1|dip:DIP-44291N	-	-	-	figure legend:Table S2-66|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:/arNBsrkXe4KcqIqBw4BEwYZHt49606	intact-crc:B5D951C5D16C5CB0	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10082	uniprotkb:P49146	intact:EBI-6655667|ensembl:ENSP00000353198|uniprotkb:Q5U5Q6|uniprotkb:Q6FGH8	intact:EBI-6655721|ensembl:ENSP00000332591|ensembl:ENSP00000426366|uniprotkb:Q13281|uniprotkb:Q13457|uniprotkb:Q4W5G7|uniprotkb:Q6AZZ6|uniprotkb:Q9UE67	psi-mi:pyy_human(display_long)|uniprotkb:PYY(gene name)|psi-mi:PYY(display_short)|uniprotkb:PYY-I(gene name synonym)|uniprotkb:Peptide tyrosine tyrosine(gene name synonym)	psi-mi:npy2r_human(display_long)|uniprotkb:NPY2R(gene name)|psi-mi:NPY2R(display_short)|uniprotkb:NPY-Y2 receptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655758|imex:IM-20536-42	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011523337.1|ensembl:ENST00000360085(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007631"(feeding behavior)|go:"GO:0031841"(neuropeptide Y receptor binding)|go:"GO:0060575"(intestinal epithelial cell differentiation)|interpro:IPR001955(Pancreatic hormone)|interpro:IPR020392|rcsb pdb:2DEZ|rcsb pdb:2DF0|rcsb pdb:2L60|rcsb pdb:2NA5|reactome:R-HSA-375276|reactome:R-HSA-418594|ensembl:ENSG00000131096(gene)|refseq:NP_004151.3	ensembl:ENSG00000185149(gene)|ensembl:ENST00000329476(transcript)|ensembl:ENST00000506608(transcript)|go:"GO:0001601"(peptide YY receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0004983"(neuropeptide Y receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0031645"(negative regulation of nervous system process)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097730"(non-motile cilium)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000611(Neuropeptide Y receptor)|interpro:IPR001358(Neuropeptide Y2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2IK3|reactome:R-HSA-375276|reactome:R-HSA-418594|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046010"(positive regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0046903"(secretion)|go:"GO:0051048"(negative regulation of secretion)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|refseq:NP_000901.1|refseq:XP_005263090.1|refseq:XP_005263091.1	-	-	-	figure legend:Table S2-80|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:VKGXqAYXru2Kad45HYBcvqSIEyY9606	rogid:wplTy6jjEmXCuJwHL5UZR0mcQQY9606	intact-crc:A42ACAB56245275F|rigid:DInTsbBcECAKfcjYOmC9IHR2Q7s	false	125i radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P20366-PRO_0000033534	uniprotkb:P21452	intact:EBI-6655449	intact:EBI-6655413|ensembl:ENSP00000362403|uniprotkb:A8K7I1|uniprotkb:Q4QRI5|uniprotkb:Q8NGQ8|uniprotkb:Q9UDE6|uniprotkb:Q9UDE7	psi-mi:p20366-pro_0000033534(display_long)|uniprotkb:TAC1(gene name)|psi-mi:TAC1(display_short)|uniprotkb:NKA(gene name synonym)|uniprotkb:NKNA(gene name synonym)|uniprotkb:TAC2(gene name synonym)|uniprotkb:PPT(gene name synonym)	psi-mi:nk2r_human(display_long)|uniprotkb:TACR2(gene name)|psi-mi:TACR2(display_short)|uniprotkb:NK2R(gene name synonym)|uniprotkb:NKNAR(gene name synonym)|uniprotkb:TAC2R(gene name synonym)|uniprotkb:NK-2 receptor(gene name synonym)|uniprotkb:Neurokinin A receptor(gene name synonym)|uniprotkb:Tachykinin receptor 2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655397|imex:IM-20536-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-717291(chain-parent)	ensembl:ENSG00000075073(gene)|ensembl:ENST00000373306(transcript)|go:"GO:0004995"(tachykinin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014827"(intestine smooth muscle contraction)|go:"GO:0016497"(substance K receptor activity)|go:"GO:0033685"(negative regulation of luteinizing hormone secretion)|go:"GO:0035106"(operant conditioning)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061827"(sperm head)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0097225"(sperm midpiece)|go:"GO:1902093"(positive regulation of flagellated sperm motility)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000913(Neurokinin NK2 receptor)|interpro:IPR001681(Neurokinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-380095|reactome:R-HSA-416476|go:"GO:0006936"(muscle contraction)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007588"(excretion)|refseq:NP_001048.2	-	chain-seq-start:98|chain-seq-end:107	-	figure legend:Table S2-73|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:/rjPbrRHAVerwGGyd9WHq5Zu90o9606	rogid:uJSOYMX5h4Vmd1Q34xaBobs39mg9606	intact-crc:4FB6FC4DA0E44C99|rigid:HgJnOMykkRRuUuAdU4BLd2pIJCA	false	125i radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P01042-PRO_0000006687	uniprotkb:P46663	intact:EBI-6623250	intact:EBI-6623218|ensembl:ENSP00000216629|ensembl:ENSP00000479276|uniprotkb:A8K7F5|uniprotkb:Q546S7|uniprotkb:Q8N0Y8	psi-mi:p01042-pro_0000006687(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym)	psi-mi:bkrb1_human(display_long)|uniprotkb:BDKRB1(gene name)|psi-mi:BDKRB1(display_short)|uniprotkb:BRADYB1(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623212|imex:IM-20536-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6378713(chain-parent)	ensembl:ENSG00000100739(gene)|ensembl:ENST00000216629(transcript)|ensembl:ENST00000611804(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004947"(bradykinin receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016477"(cell migration)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042277"(peptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000496(Bradykinin receptor)|interpro:IPR001186(B1 bradykinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P46663|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0005887"(integral component of plasma membrane)|refseq:NP_000701.2	-	chain-seq-start:380|chain-seq-end:389	-	figure legend:Table S2-19|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:I9163lorKr5wNUwjvXtsGKmU44U9606	rogid:zLDqHX33iA1qRDAIHTYlD3P9kUA9606	intact-crc:D56BFDFF9E4BABE4|rigid:hfoe86jMuEVB5pHBaIhk5W5sHOo	false	sufficient binding region:1-9|3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:64093"	uniprotkb:Q01959	intact:EBI-6661491	intact:EBI-6661445|ensembl:ENSP00000270349|ensembl:ENSP00000479597|uniprotkb:A2RUN4|uniprotkb:Q14996	psi-mi:gbr12935(display_short)|psi-mi:"CHEBI:64093"(display_long)	psi-mi:sc6a3_human(display_long)|uniprotkb:SLC6A3(gene name)|psi-mi:SLC6A3(display_short)|uniprotkb:DAT1(gene name synonym)|uniprotkb:Solute carrier family 6 member 3(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6661500|imex:IM-20536-125	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0015844"(monoamine transport)|go:"GO:0015872"(dopamine transport)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015874"(norepinephrine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0009986"(cell surface)|go:"GO:0016600"(flotillin complex)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0030424"(axon)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0035094"(response to nicotine)|go:"GO:0035240"(dopamine binding)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042420"(dopamine catabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051591"(response to cAMP)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0090494"(dopamine uptake)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0010039"(response to iron ion)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1990384"(hyaloid vascular plexus regression)|interpro:IPR000175("Sodium:neurotransmitter symporter")|interpro:IPR002436("Sodium:neurotransmitter symporter, dopamine")|interpro:IPR037272|mint:Q01959|reactome:R-HSA-379401|reactome:R-HSA-442660|reactome:R-HSA-5619081|reactome:R-HSA-5660724|ensembl:ENSG00000142319(gene)|ensembl:ENSG00000276996(gene)|ensembl:ENST00000270349(transcript)|ensembl:ENST00000621716(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005330"("dopamine:sodium symporter activity")|go:"GO:0005334"("norepinephrine:sodium symporter activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007568"(aging)|go:"GO:0007595"(lactation)|go:"GO:0007608"(sensory perception of smell)|refseq:NP_001035.1|dip:DIP-41827N	-	-	-	figure legend:Table S2-123|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:mQKSGpeovNv4Sg8T2E3A8rVB2aY9606	intact-crc:B5C2DB6FA6B57CC8	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q00975	uniprotkb:P01522	intact:EBI-1055161|uniprotkb:B1AQK5|ensembl:ENSP00000360423	intact:EBI-6656990	psi-mi:cac1b_human(display_long)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide isoform 5(gene name synonym)|uniprotkb:Brain calcium channel III(gene name synonym)|uniprotkb:CACNA1B(gene name)|psi-mi:CACNA1B(display_short)|uniprotkb:CACH5(gene name synonym)|uniprotkb:CACNL1A5(gene name synonym)	psi-mi:o16a_conge(display_long)|uniprotkb:SNX-124(gene name synonym)|uniprotkb:Shaker peptide(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6491(conge)|taxid:6491(Conus geographus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6657009|imex:IM-20536-54	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000709.1|refseq:NP_001230741.1|ensembl:ENSG00000148408(gene)|ensembl:ENST00000371372(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0045202"(synapse)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0070509"(calcium ion import)|go:"GO:1904645"(response to amyloid-beta)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005447(Voltage-dependent calcium channel, N-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR043203|rcsb pdb:2LCM|reactome:R-HSA-112308	go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0090729"(toxin activity)|go:"GO:0005576"(extracellular region)|interpro:IPR004214(Conotoxin)|interpro:IPR012321(Conotoxin, omega-type, conserved site)|rcsb pdb:1OMC|rcsb pdb:1TR6|rcsb pdb:1TTL|rcsb pdb:2CCO	-	-	-	figure legend:Table S2-119|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:R7OVT/57HywIdiczIgCa+cjqifA9606	rogid:iQiK7Kd7wlU5HgcRIbh/Hq0L9m06491	intact-crc:34AC8543A63413B2|rigid:oZg4tWmknmL/NAe3MLVTZvtOtdE	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:9667"	uniprotkb:P04150	intact:EBI-6656705	intact:EBI-493507|uniprotkb:P04151|uniprotkb:Q53EP5|uniprotkb:Q6N0A4|uniprotkb:B0LPG8|uniprotkb:D3DQF4|uniprotkb:A0ZXF9|uniprotkb:F5ATB7|ensembl:ENSP00000343205|ensembl:ENSP00000377977|ensembl:ENSP00000427672	psi-mi:triamcinolone(display_short)|psi-mi:"CHEBI:9667"(display_long)	psi-mi:gcr_human(display_long)|uniprotkb:Nuclear receptor subfamily 3 group C member 1(gene name synonym)|uniprotkb:NR3C1(gene name)|psi-mi:NR3C1(display_short)|uniprotkb:GRL(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656713|imex:IM-20536-116	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000167.1|refseq:NP_001018084.1|refseq:NP_001018085.1|refseq:NP_001018086.1|refseq:NP_001018087.1|refseq:NP_001018661.1|refseq:NP_001019265.1|refseq:NP_001191187.1|refseq:NP_001191188.1|refseq:NP_001191189.1|refseq:NP_001191190.1|refseq:NP_001191191.1|refseq:NP_001191192.1|refseq:NP_001191193.1|refseq:XP_005268476.1|refseq:XP_005268477.1|refseq:XP_005268479.1|refseq:XP_005268480.1|ensembl:ENSG00000113580(gene)|ensembl:ENST00000343796(transcript)|ensembl:ENST00000394464(transcript)|ensembl:ENST00000503201(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0004883"(glucocorticoid receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007165"(signal transduction)|rcsb pdb:5E69|rcsb pdb:5E6A|rcsb pdb:5E6B|go:"GO:0008270"(zinc ion binding)|go:"GO:0016607"(nuclear speck)|rcsb pdb:5E6C|rcsb pdb:5E6D|go:"GO:0019901"(protein kinase binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990239"(steroid hormone binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001409(Glucocorticoid receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P04150|rcsb pdb:1M2Z|rcsb pdb:1NHZ|rcsb pdb:1P93|rcsb pdb:3BQD|rcsb pdb:3CLD|rcsb pdb:3E7C|rcsb pdb:3H52|rcsb pdb:3K22|rcsb pdb:3K23|rcsb pdb:4CSJ|rcsb pdb:4HN5|rcsb pdb:4HN6|rcsb pdb:4LSJ|rcsb pdb:4MDD|rcsb pdb:4P6W|rcsb pdb:4P6X|rcsb pdb:4UDC|rcsb pdb:4UDD|rcsb pdb:5CBX|rcsb pdb:5CBY|rcsb pdb:5CBZ|rcsb pdb:5CC1|refseq:XP_016864886.1|refseq:XP_016864887.1|rcsb pdb:5EMC|rcsb pdb:5EMP|rcsb pdb:5EMQ|rcsb pdb:5G3J|rcsb pdb:5G5W|rcsb pdb:5NFP|rcsb pdb:5NFT|rcsb pdb:5UC3|rcsb pdb:5VA0|rcsb pdb:5VA7|rcsb pdb:6BQU|rcsb pdb:6CFN|rcsb pdb:6DXK|rcsb pdb:6EL6|rcsb pdb:6EL7|rcsb pdb:6EL9|rcsb pdb:6X6D|rcsb pdb:6X6E|rcsb pdb:6YMO|rcsb pdb:6YO8|rcsb pdb:6YOS|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-400253|reactome:R-HSA-4090294|reactome:R-HSA-8849473|reactome:R-HSA-8939902|reactome:R-HSA-9615017|reactome:R-HSA-9679191|dip:DIP-576N	-	-	-	figure legend:Table S2-107|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:4IOUe8VfG++O0M9uS6phAd8TBzw9606	intact-crc:4BE3D96A41A47DBD	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73378"	uniprotkb:P28335	intact:EBI-6656400	intact:EBI-994141|uniprotkb:Q5VUF8|uniprotkb:Q9NP28|ensembl:ENSP00000276198|ensembl:ENSP00000361018|ensembl:ENSP00000361019|uniprotkb:B1AMW4	psi-mi:mesulergine(display_short)|psi-mi:"CHEBI:73378"(display_long)	psi-mi:5ht2c_human(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656402|imex:IM-20536-106	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000859.1|ensembl:ENSG00000147246(gene)|ensembl:ENST00000276198(transcript)|ensembl:ENST00000371950(transcript)|ensembl:ENST00000371951(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P28335|rcsb pdb:6BQG|rcsb pdb:6BQH|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|refseq:NP_001243690.1|refseq:NP_001243689.1	-	-	-	figure legend:Table S2-98|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	intact-crc:1022D4012189754D	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P30989	uniprotkb:P30990-PRO_0000019524	intact:EBI-6655774|ensembl:ENSP00000359532|uniprotkb:Q9H4H1|uniprotkb:Q9H4T5	intact:EBI-6655817	psi-mi:ntr1_human(display_long)|uniprotkb:NTSR1(gene name)|psi-mi:NTSR1(display_short)|uniprotkb:NTRR(gene name synonym)|uniprotkb:High-affinity levocabastine-insensitive neurotensin receptor(gene name synonym)|uniprotkb:NTRH(gene name synonym)	psi-mi:p30990-pro_0000019524(display_long)|uniprotkb:NTS(gene name)|psi-mi:NTS(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655833|imex:IM-20536-44	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101188(gene)|ensembl:ENST00000370501(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014054"(positive regulation of gamma-aminobutyric acid secretion)|go:"GO:0016492"(G protein-coupled neurotensin receptor activity)|go:"GO:0032280"(symmetric synapse)|go:"GO:0033993"(response to lipid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0071545"(inositol phosphate catabolic process)|go:"GO:0090238"(positive regulation of arachidonic acid secretion)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098900"(regulation of action potential)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003984(Neurotensin receptor)|interpro:IPR003985(Neurotensin type 1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LYW|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6PWC|rcsb pdb:6UP7|reactome:R-HSA-375276|reactome:R-HSA-416476|go:"GO:0043197"(dendritic spine)|refseq:NP_002522.2|dip:DIP-60977N	intact:EBI-6655799(chain-parent)	-	-	chain-seq-start:151|chain-seq-end:163	figure legend:Table S2-82|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:uT00/8k3tTn1EaC7MWQAlibNf589606	rogid:GDDhFTmWE6kC6ipFhUMRV/mpEdQ9606	intact-crc:9A05D557D0333F8C|rigid:6CZHfjb/UN1tWWd0FkktW1EFJVU	false	-	125i radiolabel:3-3	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73303"	uniprotkb:P25021	intact:EBI-6625245	intact:EBI-6625213|ensembl:ENSP00000231683|uniprotkb:B5BUP7|uniprotkb:Q14464|uniprotkb:Q7Z5R9	psi-mi:aminopotentidine(display_short)|psi-mi:"CHEBI:73303"(display_long)	psi-mi:hrh2_human(display_long)|uniprotkb:HRH2(gene name)|psi-mi:HRH2(display_short)|uniprotkb:Gastric receptor I(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6626022|imex:IM-20536-83	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000113749(gene)|go:"GO:0001696"(gastric acid secretion)|go:"GO:0004969"(histamine receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|ensembl:ENST00000231683(transcript)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000503(Histamine H2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390650|reactome:R-HSA-418555|reactome:R-HSA-9660821|refseq:NP_001124527.1|refseq:NP_071640.1	-	-	-	figure legend:Table S2-58|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:YT7Yjq76DeARz0+/Ffkz+WPnsdw9606	intact-crc:0AE50F44E903B2AC	false	125i radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P51677	uniprotkb:P51671	intact:EBI-6625120|ensembl:ENSP00000350003|ensembl:ENSP00000379271|ensembl:ENSP00000379273|uniprotkb:B3KVQ1|uniprotkb:Q15748|uniprotkb:Q2YDB9|uniprotkb:Q86WD2|uniprotkb:Q9ULY8|uniprotkb:F5GWL6|uniprotkb:Q8TDP6	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	psi-mi:ccr3_human(display_long)|uniprotkb:CCR3(gene name)|psi-mi:CCR3(display_short)|uniprotkb:CMKBR3(gene name synonym)|uniprotkb:Eosinophil eotaxin receptor(gene name synonym)	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6625108|imex:IM-20536-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183625(gene)|ensembl:ENST00000395940(transcript)|ensembl:ENST00000395942(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0060326"(cell chemotaxis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002238(C-C chemokine receptor, type 3)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-380108|reactome:R-HSA-418594|ensembl:ENST00000357422(transcript)|refseq:XP_011531637.1|refseq:NP_001828.1|refseq:NP_847899.1|refseq:NP_847898.1|refseq:XP_006713023.1|dip:DIP-5846N	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	-	-	-	figure legend:Table S2-52|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:kDi5hBQAA6JsNVK1e6ZlG89jGsM9606	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	intact-crc:DCB8C574989134D5|rigid:YGd0LHYu4Zwh2FKHF8nxLXsA4AA	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P24394	uniprotkb:P05112	intact:EBI-367009|uniprotkb:Q96P01|uniprotkb:Q9H181|uniprotkb:Q9H182|uniprotkb:Q9H183|uniprotkb:Q9H184|uniprotkb:Q9H185|uniprotkb:Q9H186|uniprotkb:Q9H187|uniprotkb:Q9H188|uniprotkb:B4E076|uniprotkb:B9EKU8|uniprotkb:H3BSY5|ensembl:ENSP00000379111|ensembl:ENSP00000441667	intact:EBI-367025|uniprotkb:Q14630|uniprotkb:Q6NZ77|ensembl:ENSP00000231449	psi-mi:il4ra_human(display_long)|uniprotkb:IL4R(gene name)|psi-mi:IL4R(display_short)|uniprotkb:582J2.1(orf name)|uniprotkb:IL4RA(gene name synonym)	psi-mi:il4_human(display_long)|uniprotkb:IL4(gene name)|psi-mi:IL4(display_short)|uniprotkb:B-cell stimulatory factor 1(gene name synonym)|uniprotkb:Lymphocyte stimulatory factor 1(gene name synonym)|uniprotkb:Binetrakin(gene name synonym)|uniprotkb:Pitrakinra(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624920|imex:IM-20536-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001244336.1|refseq:NP_000409.1|refseq:XP_011544127.1|refseq:XP_011544128.1|refseq:XP_011544129.1|refseq:NP_001244335.1|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901741"(positive regulation of myoblast fusion)|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3BPO|go:"GO:1990834"(response to odorant)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015319(Interleukin-4 receptor alpha chain, N-terminal)|interpro:IPR036116|rcsb pdb:1IAR|rcsb pdb:5E4E|rcsb pdb:6OEL|rcsb pdb:1IRS|rcsb pdb:1ITE|rcsb pdb:6WGL|reactome:R-HSA-6785807|ensembl:ENSG00000077238(gene)|ensembl:ENST00000395762(transcript)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENST00000543915(transcript)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043627"(response to estrogen)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004913"(interleukin-4 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0030728"(ovulation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-3223N	refseq:NP_000580.1|refseq:NP_758858.1|ensembl:ENSG00000113520(gene)|ensembl:ENST00000231449(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005136"(interleukin-4 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031296"(B cell costimulation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042116"(macrophage activation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000424"(positive regulation of eosinophil chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR002354(Interleukin 4)|interpro:IPR009079(Four-helical cytokine-like, core)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|rcsb pdb:1BBN|rcsb pdb:1BCN|rcsb pdb:1CYL|rcsb pdb:1HIJ|rcsb pdb:1HIK|rcsb pdb:1HZI|rcsb pdb:1IAR|rcsb pdb:1ILL|rcsb pdb:1ITE|rcsb pdb:1ITI|rcsb pdb:1ITL|rcsb pdb:1ITM|rcsb pdb:1RCB|rcsb pdb:2B8U|rcsb pdb:2B8X|rcsb pdb:2B8Y|rcsb pdb:2B8Z|rcsb pdb:2B90|rcsb pdb:2B91|rcsb pdb:2CYK|rcsb pdb:2D48|rcsb pdb:2INT|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3QB7|rcsb pdb:4YDY|rcsb pdb:5FHX|rcsb pdb:6OEL|reactome:R-HSA-6785807|reactome:R-HSA-9012546|interpro:IPR018096|dip:DIP-3222N	-	-	-	figure legend:Table S2-48|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:18E1cLQsvHGc0WRFqUzuGssLVg09606	rogid:Jmojsmx7uQfFInaExASOKFttPFk9606	intact-crc:F5D60CBDAC113285|rigid:DtvGhEVCBmLTfHPis5cgG5lD46Q	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P01019-PRO_0000032458	uniprotkb:P30556	intact:EBI-6622938	intact:EBI-6623016|uniprotkb:Q8TBK4|ensembl:ENSP00000273430|ensembl:ENSP00000385612|ensembl:ENSP00000418084|ensembl:ENSP00000418851|ensembl:ENSP00000419422|ensembl:ENSP00000419783|ensembl:ENSP00000385641|ensembl:ENSP00000398832|uniprotkb:Q13725	psi-mi:p01019-pro_0000032458(display_long)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)|uniprotkb:Serpin A8(gene name synonym)	psi-mi:agtr1_human(display_long)|uniprotkb:AGTR1(gene name)|psi-mi:AGTR1(display_short)|uniprotkb:AGTR1A(gene name synonym)|uniprotkb:AGTR1B(gene name synonym)|uniprotkb:AT2R1(gene name synonym)|uniprotkb:AT2R1B(gene name synonym)|uniprotkb:AT1AR(gene name synonym)|uniprotkb:AT1BR(gene name synonym)|uniprotkb:Angiotensin II type-1 receptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622932|imex:IM-20536-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-751728(chain-parent)	refseq:NP_114038.4|refseq:NP_114438.2|ensembl:ENSG00000144891(gene)|ensembl:ENST00000349243(transcript)|ensembl:ENST00000402260(transcript)|ensembl:ENST00000404754(transcript)|ensembl:ENST00000461609(transcript)|ensembl:ENST00000474935(transcript)|ensembl:ENST00000475347(transcript)|ensembl:ENST00000497524(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001822"(kidney development)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|ensembl:ENST00000418473(transcript)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30556|rcsb pdb:1ZV0|rcsb pdb:4YAY|rcsb pdb:4ZUD|rcsb pdb:6DO1|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0019229"(regulation of vasoconstriction)|refseq:NP_004826.5|refseq:NP_000676.1|refseq:NP_033611.1	-	chain-seq-start:34|chain-seq-end:41	-	figure legend:Table S2-13|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:hq8n3YTVT4kiQ6W0wa89kcCJUQY9606	rogid:hrgCoboCmBvuoZEj5YuPnL+KuEQ9606	intact-crc:CFE99E0F2E164F18|rigid:HZpRTL9FsKo3gZ1wvQgz7QaJimg	false	mutation:1-1|mutation:8-8|125i radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:4460"	uniprotkb:P32238	intact:EBI-6623716	intact:EBI-6623485|ensembl:ENSP00000295589|uniprotkb:B2R9Z5	psi-mi:devazepide(display_short)|psi-mi:"CHEBI:4460"(display_long)	psi-mi:cckar_human(display_long)|uniprotkb:CCKAR(gene name)|psi-mi:CCKAR(display_short)|uniprotkb:CCKRA(gene name synonym)|uniprotkb:Cholecystokinin-1 receptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624381|imex:IM-20536-75	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000163394(gene)|ensembl:ENST00000295589(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004951"(cholecystokinin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0016020"(membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030900"(forebrain development)|go:"GO:0038188"(cholecystokinin signaling pathway)|go:"GO:0046883"(regulation of hormone secretion)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000596(Cholecystokinin receptor, type A)|interpro:IPR009126(Cholecystokinin receptor)|interpro:IPR015276(Cholecystokinin A receptor, N-terminal)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR036472|mint:P32238|rcsb pdb:1D6G|rcsb pdb:1HZN|rcsb pdb:1PB2|rcsb pdb:7MBX|rcsb pdb:7MBY|reactome:R-HSA-375276|reactome:R-HSA-416476|refseq:NP_000721.1	-	-	-	figure legend:Table S2-30|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:Rztt+6h5ZHjM/fZTCETQI93bucU9606	intact-crc:C8B8CD2C8A16507A	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P24530	uniprotkb:P05305	intact:EBI-6624656|uniprotkb:A2A2Z8|uniprotkb:A8K3T4|uniprotkb:O15343|uniprotkb:Q59GB1|uniprotkb:Q5W0G9|uniprotkb:Q8NHM6|uniprotkb:Q8NHM7|uniprotkb:Q8NHM8|uniprotkb:Q8NHM9|uniprotkb:Q9UD23|uniprotkb:Q9UQK3|ensembl:ENSP00000487082|ensembl:ENSP00000493527|ensembl:ENSP00000493895|ensembl:ENSP00000494278	intact:EBI-715181|uniprotkb:Q96DA1|ensembl:ENSP00000368683	psi-mi:ednrb_human(display_long)|uniprotkb:EDNRB(gene name)|psi-mi:EDNRB(display_short)|uniprotkb:ETRB(gene name synonym)|uniprotkb:Endothelin receptor non-selective type(gene name synonym)	psi-mi:edn1_human(display_long)|uniprotkb:Preproendothelin-1(gene name synonym)|uniprotkb:EDN1(gene name)|psi-mi:EDN1(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624725|imex:IM-20536-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000106.1|refseq:NP_001116131.1|refseq:NP_001188326.1|refseq:NP_003982.1|ensembl:ENSG00000136160(gene)|ensembl:ENST00000475537(transcript)|ensembl:ENST00000646605(transcript)|ensembl:ENST00000646607(transcript)|ensembl:ENST00000646948(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004962"(endothelin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006885"(regulation of pH)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007497"(posterior midgut development)|go:"GO:0007568"(aging)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014043"(negative regulation of neuron maturation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014826"(vein smooth muscle contraction)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031620"(regulation of fever generation)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0035645"(enteric smooth muscle cell differentiation)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042311"(vasodilation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048265"(response to pain)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:1990839"(response to endothelin)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000499(Endothelin receptor)|interpro:IPR001112(Endothelin B receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P24530|rcsb pdb:5GLH|rcsb pdb:5GLI|rcsb pdb:5X93|rcsb pdb:5XPR|rcsb pdb:6IGK|rcsb pdb:6IGL|rcsb pdb:6LRY|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_001161791.1|refseq:NP_001946.3|refseq:XP_016865820.1|refseq:XP_011512632.1|refseq:XP_011512633.1|go:"GO:0007507"(heart development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007589"(body fluid secretion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010193"(response to ozone)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014826"(vein smooth muscle contraction)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030133"(transport vesicle)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031583"(phospholipase D-activating G protein-coupled receptor signaling pathway)|go:"GO:0031707"(endothelin A receptor binding)|go:"GO:0031708"(endothelin B receptor binding)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0042310"(vasoconstriction)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0033574"(response to testosterone)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0034696"(response to prostaglandin F)|go:"GO:0035094"(response to nicotine)|go:"GO:0035690"|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042313"(protein kinase C deactivation)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042482"(positive regulation of odontogenesis)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043179"(rhythmic excitation)|go:"GO:0043200"(response to amino acid)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044321"(response to leptin)|go:"GO:0045178"(basal part of cell)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048016"(inositol phosphate-mediated signaling)|go:"GO:0048237"(rough endoplasmic reticulum lumen)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0060298"(positive regulation of sarcomere organization)|go:"GO:0060585"(positive regulation of prostaglandin-endoperoxide synthase activity)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0030072"(peptide hormone secretion)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071389"(cellular response to mineralocorticoid stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902074"(response to salt)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR001928(Endothelin-like toxin)|interpro:IPR019764|interpro:IPR020475|rcsb pdb:1EDN|rcsb pdb:1EDP|rcsb pdb:1T7H|rcsb pdb:1V6R|rcsb pdb:5GLH|rcsb pdb:6DK5|reactome:R-HSA-375276|reactome:R-HSA-416476|ensembl:ENSG00000078401(gene)|ensembl:ENST00000379375(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001821"(histamine secretion)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006885"(regulation of pH)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)	-	-	-	figure legend:Table S2-40|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:EVPfuNkUH6NzN8Jo1EjipkRmqSU9606	rogid:rQ9w4UJP9y2E/71at8Js4ZdXY/A9606	intact-crc:3A2CB6A2832DCF6C|rigid:eX/64qnbrIAiY9e3liK2BDOF6GQ	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25025	uniprotkb:P10145	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-3917999|uniprotkb:Q9UCS0|uniprotkb:Q9UCR8|uniprotkb:Q9C077|uniprotkb:Q6FGF6|uniprotkb:Q96RG6|uniprotkb:B2R4L8|uniprotkb:Q9UCE1|uniprotkb:Q9UCR9|uniprotkb:Q6LAE6|ensembl:ENSP00000306512	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:il8_human(display_long)|uniprotkb:Protein 3-10C(gene name synonym)|uniprotkb:T-cell chemotactic factor(gene name synonym)|uniprotkb:CXCL8(gene name)|psi-mi:CXCL8(display_short)|uniprotkb:C-X-C motif chemokine 8(gene name synonym)|uniprotkb:"Chemokine (C-X-C motif) ligand 8"(gene name synonym)|uniprotkb:Emoctakin(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 1(gene name synonym)|uniprotkb:IL8(gene name synonym)|uniprotkb:Monocyte-derived neutrophil chemotactic factor(gene name synonym)|uniprotkb:Monocyte-derived neutrophil-activating peptide(gene name synonym)|uniprotkb:Neutrophil-activating protein 1(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624936|imex:IM-20536-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	refseq:NP_000575.1|ensembl:ENSG00000169429(gene)|ensembl:ENST00000307407(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005153"(interleukin-8 receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-6785807|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031623"(receptor internalization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042119"(neutrophil activation)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045091"(regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006935"(chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR028469|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1ICW|rcsb pdb:1IKL|rcsb pdb:1IKM|rcsb pdb:1IL8|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|rcsb pdb:1ILQ|rcsb pdb:1QE6|rcsb pdb:1ROD|rcsb pdb:2IL8|rcsb pdb:3IL8|rcsb pdb:4XDX|rcsb pdb:5D14|rcsb pdb:5WDZ|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6N2U|rcsb pdb:6WZM|reactome:R-HSA-2559582|reactome:R-HSA-375276|rcsb pdb:1ILP|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-3778N	-	-	-	figure legend:Table S2-50|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:aC4GQA1hEtGxhjdfmoeStVe8Mf09606	intact-crc:6606DE70013954C8|rigid:e4uyUXs6BKclebixsy3U0ow4peY	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:9233"	uniprotkb:P14416	intact:EBI-6624539	intact:EBI-2928178|ensembl:ENSP00000354859|ensembl:ENSP00000442172|uniprotkb:Q9NZR3|uniprotkb:Q9UPA9	psi-mi:spiperone(display_short)|psi-mi:"CHEBI:9233"(display_long)	psi-mi:drd2_human(display_long)|uniprotkb:DRD2(gene name)|psi-mi:DRD2(display_short)|uniprotkb:Dopamine D2 receptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624531|imex:IM-20536-78	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000149295(gene)|ensembl:ENST00000362072(transcript)|ensembl:ENST00000542968(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007616"(long-term memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014854"(response to inactivity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031223"(auditory behavior)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034776"(response to histamine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035240"(dopamine binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042220"(response to cocaine)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0042756"(drinking behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0043204"(perikaryon)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0043473"(pigmentation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046717"(acid secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048678"(response to axon injury)|go:"GO:0048755"(branching morphogenesis of a nerve)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0060160"(negative regulation of dopamine receptor signaling pathway)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090325"(regulation of locomotion involved in locomotory behavior)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1990384"(hyaloid vascular plexus regression)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001922(Dopamine D2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P14416|rcsb pdb:1I15|rcsb pdb:5AER|rcsb pdb:6CM4|rcsb pdb:6LUQ|rcsb pdb:6VMS|rcsb pdb:7JVR|reactome:R-HSA-390651|go:"GO:0051823"(regulation of synapse structural plasticity)|refseq:NP_000786.1|refseq:NP_057658.2|refseq:XP_016872785.1|dip:DIP-5977N	-	-	-	figure legend:Table S2-35|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:10.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:S5beCpwOapTeUXcS45WlU5ApKEI9606	intact-crc:3083128B44BBDC31	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73298"	uniprotkb:P14416	intact:EBI-6624541	intact:EBI-2928178|ensembl:ENSP00000354859|ensembl:ENSP00000442172|uniprotkb:Q9NZR3|uniprotkb:Q9UPA9	psi-mi:butaclamol(display_short)|psi-mi:"CHEBI:73298"(display_long)	psi-mi:drd2_human(display_long)|uniprotkb:DRD2(gene name)|psi-mi:DRD2(display_short)|uniprotkb:Dopamine D2 receptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6624531|imex:IM-20536-78	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000149295(gene)|ensembl:ENST00000362072(transcript)|ensembl:ENST00000542968(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007616"(long-term memory)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014854"(response to inactivity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031223"(auditory behavior)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034776"(response to histamine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035240"(dopamine binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042220"(response to cocaine)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0042756"(drinking behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0043204"(perikaryon)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0043473"(pigmentation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046717"(acid secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048678"(response to axon injury)|go:"GO:0048755"(branching morphogenesis of a nerve)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0060160"(negative regulation of dopamine receptor signaling pathway)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090325"(regulation of locomotion involved in locomotory behavior)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1990384"(hyaloid vascular plexus regression)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001922(Dopamine D2 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P14416|rcsb pdb:1I15|rcsb pdb:5AER|rcsb pdb:6CM4|rcsb pdb:6LUQ|rcsb pdb:6VMS|rcsb pdb:7JVR|reactome:R-HSA-390651|go:"GO:0051823"(regulation of synapse structural plasticity)|refseq:NP_000786.1|refseq:NP_057658.2|refseq:XP_016872785.1|dip:DIP-5977N	-	-	-	figure legend:Table S2-35|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:10.0x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:S5beCpwOapTeUXcS45WlU5ApKEI9606	intact-crc:3083128B44BBDC31	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P29371	uniprotkb:Q9UHF0-PRO_0000033566	intact:EBI-6655576|ensembl:ENSP00000303325|uniprotkb:Q0P510	intact:EBI-6655626	psi-mi:nk3r_human(display_long)|uniprotkb:TACR3(gene name)|psi-mi:TACR3(display_short)|uniprotkb:NK3R(gene name synonym)|uniprotkb:TAC3R(gene name synonym)|uniprotkb:NK-3 receptor(gene name synonym)|uniprotkb:Neurokinin B receptor(gene name synonym)|uniprotkb:Tachykinin receptor 3(gene name synonym)	psi-mi:q9uhf0-pro_0000033566(display_long)|uniprotkb:TAC3(gene name)|psi-mi:TAC3(display_short)|uniprotkb:NKNB(gene name synonym)|uniprotkb:ZNEUROK1(gene name synonym)|uniprotkb:UNQ585/PRO1155(orf name)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655654|imex:IM-20536-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169836(gene)|ensembl:ENST00000304883(transcript)|go:"GO:0004995"(tachykinin receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0032355"(response to estradiol)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0043278"(response to morphine)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0097225"(sperm midpiece)|go:"GO:1902093"(positive regulation of flagellated sperm motility)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001013(Neurokinin NK3 receptor)|interpro:IPR001681(Neurokinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-380095|reactome:R-HSA-416476|refseq:NP_001050.1	intact:EBI-717325(chain-parent)	-	-	chain-seq-start:81|chain-seq-end:90	figure legend:Table S2-76|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:6.2x10^-9(molar)	2013/04/23	2014/10/16	rogid:s8o+d0WYwijf/csy+KXJav3pBtQ9606	rogid:Fw8j1ko6ncMYd3kHssclum277e09606	intact-crc:63C4F9E8C71FDE47|rigid:S21Jp3vRMrTq8ijoY8RX6MrAKHc	false	-	mutation:7-7	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P29371	uniprotkb:Q9UHF0-PRO_0000033566	intact:EBI-6655576|ensembl:ENSP00000303325|uniprotkb:Q0P510	intact:EBI-6655626	psi-mi:nk3r_human(display_long)|uniprotkb:TACR3(gene name)|psi-mi:TACR3(display_short)|uniprotkb:NK3R(gene name synonym)|uniprotkb:TAC3R(gene name synonym)|uniprotkb:NK-3 receptor(gene name synonym)|uniprotkb:Neurokinin B receptor(gene name synonym)|uniprotkb:Tachykinin receptor 3(gene name synonym)	psi-mi:q9uhf0-pro_0000033566(display_long)|uniprotkb:TAC3(gene name)|psi-mi:TAC3(display_short)|uniprotkb:NKNB(gene name synonym)|uniprotkb:ZNEUROK1(gene name synonym)|uniprotkb:UNQ585/PRO1155(orf name)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6655654|imex:IM-20536-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169836(gene)|ensembl:ENST00000304883(transcript)|go:"GO:0004995"(tachykinin receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0032355"(response to estradiol)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0043278"(response to morphine)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0097225"(sperm midpiece)|go:"GO:1902093"(positive regulation of flagellated sperm motility)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001013(Neurokinin NK3 receptor)|interpro:IPR001681(Neurokinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-380095|reactome:R-HSA-416476|refseq:NP_001050.1	intact:EBI-717325(chain-parent)	-	-	chain-seq-start:81|chain-seq-end:90	figure legend:Table S2-76|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:6.2x10^-9(molar)	2013/04/23	2014/10/16	rogid:s8o+d0WYwijf/csy+KXJav3pBtQ9606	rogid:Fw8j1ko6ncMYd3kHssclum277e09606	intact-crc:63C4F9E8C71FDE47|rigid:S21Jp3vRMrTq8ijoY8RX6MrAKHc	false	-	mutation:7-7|125i radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:9086"	uniprotkb:P27338	intact:EBI-6662576	intact:EBI-3911344|uniprotkb:B7Z5H3|uniprotkb:B2R6R3|uniprotkb:D3DWC3|uniprotkb:Q7Z6S2|ensembl:ENSP00000367309	psi-mi:deprenyl/selegiline(display_short)|psi-mi:"CHEBI:9086"(display_long)	psi-mi:aofb_human(display_long)|uniprotkb:MAOB(gene name)|psi-mi:MAOB(display_short)|uniprotkb:Monoamine oxidase type B(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662570|imex:IM-20536-139	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000889.3|ensembl:ENSG00000069535(gene)|ensembl:ENST00000378069(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0010269"(response to selenium ion)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042135"(neurotransmitter catabolic process)|go:"GO:0042420"(dopamine catabolic process)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045964"(positive regulation of dopamine metabolic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0051412"(response to corticosterone)|go:"GO:0097621"(monoamine oxidase activity)|interpro:IPR001613(Flavin-containing amine oxidase)|interpro:IPR002937(Amine oxidase)|interpro:IPR036188|rcsb pdb:1GOS|rcsb pdb:1H8R|rcsb pdb:1OJ9|rcsb pdb:1OJA|rcsb pdb:1OJC|rcsb pdb:1OJD|rcsb pdb:1S2Q|rcsb pdb:1S2Y|rcsb pdb:1S3B|rcsb pdb:1S3E|rcsb pdb:2BK3|rcsb pdb:2BK4|rcsb pdb:2BK5|rcsb pdb:2BYB|rcsb pdb:2C64|rcsb pdb:2C65|rcsb pdb:2C66|rcsb pdb:2C67|rcsb pdb:2C70|rcsb pdb:2C72|rcsb pdb:2C73|rcsb pdb:2C75|rcsb pdb:2C76|rcsb pdb:2V5Z|rcsb pdb:2V60|rcsb pdb:2V61|rcsb pdb:2VRL|rcsb pdb:2VRM|rcsb pdb:2VZ2|rcsb pdb:2XCG|rcsb pdb:2XFN|rcsb pdb:2XFO|rcsb pdb:2XFP|rcsb pdb:2XFQ|rcsb pdb:2XFU|rcsb pdb:3PO7|rcsb pdb:3ZYX|rcsb pdb:4A79|rcsb pdb:4A7A|rcsb pdb:4CRT|rcsb pdb:5MRL|rcsb pdb:6FVZ|rcsb pdb:6FW0|rcsb pdb:6FWC|rcsb pdb:6RKB|rcsb pdb:6RKP|rcsb pdb:6RLE|rcsb pdb:6YT2|reactome:R-HSA-141333	-	-	-	figure legend:Table S2-136|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.031x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:IDk70w0RMI8dOb65dcgbrDYzSw09606	intact-crc:E6C8C058EFAB24D3	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73472"	uniprotkb:P27338	intact:EBI-6662560	intact:EBI-3911344|uniprotkb:B7Z5H3|uniprotkb:B2R6R3|uniprotkb:D3DWC3|uniprotkb:Q7Z6S2|ensembl:ENSP00000367309	psi-mi:kynuramine(display_short)|psi-mi:"CHEBI:73472"(display_long)	psi-mi:aofb_human(display_long)|uniprotkb:MAOB(gene name)|psi-mi:MAOB(display_short)|uniprotkb:Monoamine oxidase type B(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662570|imex:IM-20536-139	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000889.3|ensembl:ENSG00000069535(gene)|ensembl:ENST00000378069(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008131"(primary amine oxidase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0010269"(response to selenium ion)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042135"(neurotransmitter catabolic process)|go:"GO:0042420"(dopamine catabolic process)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045964"(positive regulation of dopamine metabolic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0051412"(response to corticosterone)|go:"GO:0097621"(monoamine oxidase activity)|interpro:IPR001613(Flavin-containing amine oxidase)|interpro:IPR002937(Amine oxidase)|interpro:IPR036188|rcsb pdb:1GOS|rcsb pdb:1H8R|rcsb pdb:1OJ9|rcsb pdb:1OJA|rcsb pdb:1OJC|rcsb pdb:1OJD|rcsb pdb:1S2Q|rcsb pdb:1S2Y|rcsb pdb:1S3B|rcsb pdb:1S3E|rcsb pdb:2BK3|rcsb pdb:2BK4|rcsb pdb:2BK5|rcsb pdb:2BYB|rcsb pdb:2C64|rcsb pdb:2C65|rcsb pdb:2C66|rcsb pdb:2C67|rcsb pdb:2C70|rcsb pdb:2C72|rcsb pdb:2C73|rcsb pdb:2C75|rcsb pdb:2C76|rcsb pdb:2V5Z|rcsb pdb:2V60|rcsb pdb:2V61|rcsb pdb:2VRL|rcsb pdb:2VRM|rcsb pdb:2VZ2|rcsb pdb:2XCG|rcsb pdb:2XFN|rcsb pdb:2XFO|rcsb pdb:2XFP|rcsb pdb:2XFQ|rcsb pdb:2XFU|rcsb pdb:3PO7|rcsb pdb:3ZYX|rcsb pdb:4A79|rcsb pdb:4A7A|rcsb pdb:4CRT|rcsb pdb:5MRL|rcsb pdb:6FVZ|rcsb pdb:6FW0|rcsb pdb:6FWC|rcsb pdb:6RKB|rcsb pdb:6RKP|rcsb pdb:6RLE|rcsb pdb:6YT2|reactome:R-HSA-141333	-	-	-	figure legend:Table S2-136|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.031x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:IDk70w0RMI8dOb65dcgbrDYzSw09606	intact-crc:E6C8C058EFAB24D3	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:15843"	uniprotkb:P35354	intact:EBI-6662097	intact:EBI-6662113|ensembl:ENSP00000356438|ensembl:ENSP00000506242|uniprotkb:A8K802|uniprotkb:Q16876	psi-mi:arachidonic acid(display_short)|psi-mi:"CHEBI:15843"(display_long)	psi-mi:pgh2_human(display_long)|uniprotkb:PTGS2(gene name)|psi-mi:PTGS2(display_short)|uniprotkb:COX2(gene name synonym)|uniprotkb:Cyclooxygenase-2(gene name synonym)|uniprotkb:PHS II(gene name synonym)|uniprotkb:Prostaglandin H2 synthase 2(gene name synonym)|uniprotkb:Prostaglandin-endoperoxide synthase 2(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6662198|imex:IM-20536-131	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000073756(gene)|ensembl:ENST00000367468(transcript)|ensembl:ENST00000680451(transcript)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001525"(angiogenesis)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004666"(prostaglandin-endoperoxide synthase activity)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005901"(caveola)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007566"(embryo implantation)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0030728"(ovulation)|go:"GO:0007613"(memory)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042633"(hair cycle)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0009750"(response to fructose)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010042"(response to manganese ion)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0010226"(response to lithium ion)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046697"(decidualization)|go:"GO:0046872"(metal ion binding)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0090362"(positive regulation of platelet-derived growth factor production)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR010255(Haem peroxidase)|interpro:IPR019791|interpro:IPR029576|interpro:IPR037120|rcsb pdb:1V0X|rcsb pdb:5F19|rcsb pdb:5F1A|rcsb pdb:5IKQ|rcsb pdb:5IKR|go:"GO:0070542"(response to fatty acid)|rcsb pdb:5IKT|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071284"(cellular response to lead ion)|rcsb pdb:5IKV|go:"GO:0071318"(cellular response to ATP)|go:"GO:0071456"(cellular response to hypoxia)|rcsb pdb:5KIR|reactome:R-HSA-197264|reactome:R-HSA-2142770|go:"GO:0071471"(cellular response to non-ionic osmotic stress)|reactome:R-HSA-2162123|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9018677|reactome:R-HSA-9018679|reactome:R-HSA-9025094|reactome:R-HSA-9027604|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|refseq:NP_000954.1|dip:DIP-28131N	-	-	-	figure legend:Table S2-129|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:WGHtPKMIVOhbG4HdzQyqaBTUH509606	intact-crc:D930F75563C4CF23	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P46663	uniprotkb:P01042-PRO_0000006688	intact:EBI-6623218|ensembl:ENSP00000216629|ensembl:ENSP00000479276|uniprotkb:A8K7F5|uniprotkb:Q546S7|uniprotkb:Q8N0Y8	intact:EBI-6623273	psi-mi:bkrb1_human(display_long)|uniprotkb:BDKRB1(gene name)|psi-mi:BDKRB1(display_short)|uniprotkb:BRADYB1(gene name synonym)	psi-mi:p01042-pro_0000006688(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623265|imex:IM-20536-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100739(gene)|ensembl:ENST00000216629(transcript)|ensembl:ENST00000611804(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004947"(bradykinin receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016477"(cell migration)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042277"(peptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000496(Bradykinin receptor)|interpro:IPR001186(B1 bradykinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P46663|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0005887"(integral component of plasma membrane)|refseq:NP_000701.2	intact:EBI-6378713(chain-parent)	-	-	chain-seq-start:381|chain-seq-end:389	figure legend:Table S2-20|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:90.0x10^-9(molar)	2013/04/23	2014/10/16	rogid:zLDqHX33iA1qRDAIHTYlD3P9kUA9606	rogid:6gWGwqbaJ8YYHgtSA8iAETGldvg9606	intact-crc:2EFAAC81FBC303F4|rigid:NmkucAXO8MFhw9xbTlRicpipCBU	false	-	mutation:8-8|sufficient binding region:1-8	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P46663	uniprotkb:P01042-PRO_0000006687	intact:EBI-6623218|ensembl:ENSP00000216629|ensembl:ENSP00000479276|uniprotkb:A8K7F5|uniprotkb:Q546S7|uniprotkb:Q8N0Y8	intact:EBI-6623250	psi-mi:bkrb1_human(display_long)|uniprotkb:BDKRB1(gene name)|psi-mi:BDKRB1(display_short)|uniprotkb:BRADYB1(gene name synonym)	psi-mi:p01042-pro_0000006687(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623265|imex:IM-20536-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100739(gene)|ensembl:ENST00000216629(transcript)|ensembl:ENST00000611804(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004947"(bradykinin receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016477"(cell migration)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042277"(peptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000496(Bradykinin receptor)|interpro:IPR001186(B1 bradykinin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P46663|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0005887"(integral component of plasma membrane)|refseq:NP_000701.2	intact:EBI-6378713(chain-parent)	-	-	chain-seq-start:380|chain-seq-end:389	figure legend:Table S2-20|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:90.0x10^-9(molar)	2013/04/23	2014/10/16	rogid:zLDqHX33iA1qRDAIHTYlD3P9kUA9606	rogid:I9163lorKr5wNUwjvXtsGKmU44U9606	intact-crc:2EFAAC81FBC303F4|rigid:NmkucAXO8MFhw9xbTlRicpipCBU	false	-	sufficient binding region:1-9|3h radiolabel:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73290"	uniprotkb:P30536	intact:EBI-6623202	intact:EBI-6623146|ensembl:ENSP00000328973|ensembl:ENSP00000338004|ensembl:ENSP00000379563|uniprotkb:Q53Y59|uniprotkb:Q6ICF9|uniprotkb:Q96TF6	psi-mi:pk-11195(display_short)|psi-mi:"CHEBI:73290"(display_long)	psi-mi:tspo_human(display_long)|uniprotkb:TSPO(gene name)|psi-mi:TSPO(display_short)|uniprotkb:BZRP(gene name synonym)|uniprotkb:MBR(gene name synonym)|uniprotkb:Mitochondrial benzodiazepine receptor(gene name synonym)|uniprotkb:PKBS(gene name synonym)|uniprotkb:Peripheral-type benzodiazepine receptor(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623140|imex:IM-20536-68	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000100300(gene)|ensembl:ENST00000329563(transcript)|ensembl:ENST00000337554(transcript)|ensembl:ENST00000396265(transcript)|go:"GO:0005497"(androgen binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006700"(C21-steroid hormone biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0007568"(aging)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008347"(glial cell migration)|go:"GO:0008503"(benzodiazepine receptor activity)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010266"(response to vitamin B1)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030325"(adrenal gland development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060242"(contact inhibition)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0032570"(response to progesterone)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903579"(negative regulation of ATP metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004307(TspO/MBR-related protein)|interpro:IPR030164|interpro:IPR038330|reactome:R-HSA-196108|go:"GO:0033574"(response to testosterone)|refseq:NP_000705.2|refseq:NP_001243459.1|refseq:NP_001243460.1	-	-	-	figure legend:Table S2-17|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:A8KFWbHly01w8pFFNMygS76hCdI9606	intact-crc:E2073150CFE95BF2	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73295"	uniprotkb:P34972	intact:EBI-6623451	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	psi-mi:win 55212-2(display_short)|psi-mi:"CHEBI:73295"(display_long)	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623453|imex:IM-20536-71	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	-	-	-	figure legend:Table S2-27|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:4.8x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	intact-crc:3A7A02CA90E6898C	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73295"	uniprotkb:P34972	intact:EBI-6623451	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	psi-mi:win 55212-2(display_short)|psi-mi:"CHEBI:73295"(display_long)	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623453|imex:IM-20536-71	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	-	-	-	figure legend:Table S2-27|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:4.8x10^-9(molar)	2013/04/23	2014/10/16	-	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	intact-crc:3A7A02CA90E6898C	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:6605"	uniprotkb:P50406	intact:EBI-6656639	intact:EBI-1182222|uniprotkb:Q5TGZ1|uniprotkb:Q13640|ensembl:ENSP00000289753	psi-mi:lsd-lysergic acid  diethylamide(display_short)|psi-mi:"CHEBI:6605"(display_long)	psi-mi:5ht6r_human(display_long)|uniprotkb:Serotonin receptor 6(gene name synonym)|uniprotkb:HTR6(gene name)|psi-mi:HTR6(display_short)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656660|imex:IM-20536-112	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000862.1|ensembl:ENSG00000158748(gene)|ensembl:ENST00000289753(transcript)|go:"GO:0004969"(histamine receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0045202"(synapse)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002232(5-Hydroxytryptamine 6 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390666|reactome:R-HSA-418555|reactome:R-HSA-9660821	-	-	-	figure legend:Table S2-104|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:SFZIoXiv9N5u58vWFklEhUXJ9Wk9606	intact-crc:7C725AAD0F6DDD01	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73364"	uniprotkb:P08908	intact:EBI-6656292	intact:EBI-6570214|ensembl:ENSP00000316244|uniprotkb:Q6LAE7	psi-mi:8-oh-dpat(display_short)|psi-mi:"CHEBI:73364"(display_long)	psi-mi:5ht1a_human(display_long)|uniprotkb:HTR1A(gene name)|psi-mi:HTR1A(display_short)|uniprotkb:ADRB2RL1(gene name synonym)|uniprotkb:ADRBRL1(gene name synonym)|uniprotkb:G-21(gene name synonym)|uniprotkb:Serotonin receptor 1A(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656294|imex:IM-20536-100	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000178394(gene)|ensembl:ENST00000323865(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014062"(regulation of serotonin secretion)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0035640"(exploration behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0045202"(synapse)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0050795"(regulation of behavior)|go:"GO:0051378"(serotonin binding)|go:"GO:0090722"(receptor-receptor interaction)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000610(5-Hydroxytryptamine 1A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|reactome:R-HSA-390666|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|refseq:NP_000515.2	-	-	-	figure legend:Table S2-92|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:EAQbnziwFuwqt4cDvISKLpVNQK49606	intact-crc:AA974C481AD7D698	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73295"	uniprotkb:P34972	intact:EBI-6623451	intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596	psi-mi:win 55212-2(display_short)|psi-mi:"CHEBI:73295"(display_long)	psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym)	psi-mi:"MI:0099"(scintillation proximity assay)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6623469|imex:IM-20536-73	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1	-	-	-	figure legend:Table S2-28|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606	intact-crc:DBE22E3992B7E78A	false	3h radiolabel:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:73280"	uniprotkb:P21802	intact:EBI-6622221	intact:EBI-1028658|uniprotkb:P18443|uniprotkb:Q01742|uniprotkb:Q12922|uniprotkb:Q14300|uniprotkb:Q14301|uniprotkb:Q14302|uniprotkb:Q14303|uniprotkb:Q14304|uniprotkb:Q14305|uniprotkb:Q14672|uniprotkb:Q14718|uniprotkb:Q14719|uniprotkb:Q86YI4|uniprotkb:Q96KL9|uniprotkb:Q96KM0|uniprotkb:Q96KM1|uniprotkb:Q96KM2|uniprotkb:Q9NZU2|uniprotkb:Q9NZU3|uniprotkb:Q9UD01|uniprotkb:Q9UD02|uniprotkb:Q9UIH3|uniprotkb:Q9UIH4|uniprotkb:Q9UIH5|uniprotkb:Q9UIH6|uniprotkb:Q9UIH7|uniprotkb:Q9UIH8|uniprotkb:Q9UM87|uniprotkb:Q9UMC6|uniprotkb:Q9UNS7|uniprotkb:Q9UQH7|uniprotkb:Q9UQH8|uniprotkb:Q9UQH9|uniprotkb:Q9UQI0|uniprotkb:Q1KHY5|ensembl:ENSP00000351276|uniprotkb:B4DFC2|uniprotkb:E7EVR6|uniprotkb:E9PCR0|uniprotkb:Q8IXC7	psi-mi:ssr(display_short)|psi-mi:"CHEBI:73280"(display_long)	psi-mi:fgfr2_human(display_long)|uniprotkb:FGFR2(gene name)|psi-mi:FGFR2(display_short)|uniprotkb:BEK(gene name synonym)|uniprotkb:KSAM(gene name synonym)|uniprotkb:Keratinocyte growth factor receptor(gene name synonym)|uniprotkb:KGFR(gene name synonym)|uniprotkb:K-sam(gene name synonym)	psi-mi:"MI:0943"(detection by mass spectrometry)	Bono et al. (2013)	pubmed:23597562|imex:IM-20536	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6622234|imex:IM-20536-55	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000132.3|refseq:NP_001138385.1|refseq:NP_001138386.1|refseq:NP_001138387.1|refseq:NP_001138388.1|refseq:NP_001138389.1|refseq:NP_001138390.1|refseq:NP_001138391.1|refseq:NP_075259.4|ensembl:ENSG00000066468(gene)|ensembl:ENST00000358487(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007409"(axonogenesis)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021847"(ventricular zone neuroblast division)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030901"(midbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0035265"(organ growth)|go:"GO:0035602"(fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell)|go:"GO:0035603"(fibroblast growth factor receptor signaling pathway involved in hemopoiesis)|go:"GO:0035604"(fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow)|go:"GO:0035607"(fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development)|go:"GO:0042060"(wound healing)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045471"(response to ethanol)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048562"(embryonic organ morphogenesis)|go:"GO:0048565"(digestive tract development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0048755"(branching morphogenesis of a nerve)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0051150"(regulation of smooth muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060174"(limb bud formation)|go:"GO:0060348"(bone development)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060512"(prostate gland morphogenesis)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060529"(squamous basal epithelial stem cell differentiation involved in prostate gland acinus development)|go:"GO:0060595"(fibroblast growth factor receptor signaling pathway involved in mammary gland specification)|go:"GO:0060601"(lateral sprouting from an epithelium)|go:"GO:0060615"(mammary gland bud formation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060667"(branch elongation involved in salivary gland morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060688"(regulation of morphogenesis of a branching structure)|go:"GO:0060915"(mesenchymal cell differentiation involved in lung development)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041159|mint:P21802|rcsb pdb:1DJS|rcsb pdb:1E0O|rcsb pdb:1EV2|rcsb pdb:1GJO|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:1NUN|rcsb pdb:1OEC|rcsb pdb:1WVZ|rcsb pdb:2FDB|rcsb pdb:2PSQ|rcsb pdb:2PVF|rcsb pdb:2PVY|rcsb pdb:2PWL|rcsb pdb:2PY3|rcsb pdb:2PZ5|rcsb pdb:2PZP|rcsb pdb:2PZR|rcsb pdb:2Q0B|rcsb pdb:3B2T|rcsb pdb:3CAF|rcsb pdb:3CLY|rcsb pdb:3CU1|rcsb pdb:3DAR|rcsb pdb:3EUU|rcsb pdb:3OJ2|rcsb pdb:3OJM|rcsb pdb:3RI1|rcsb pdb:4J23|rcsb pdb:4J95|rcsb pdb:4J96|rcsb pdb:4J97|rcsb pdb:4J98|rcsb pdb:4J99|rcsb pdb:4WV1|rcsb pdb:5EG3|rcsb pdb:5UGL|rcsb pdb:5UGX|rcsb pdb:5UHN|rcsb pdb:5UI0|rcsb pdb:6AGX|rcsb pdb:6LVK|rcsb pdb:6LVL|rcsb pdb:6V6Q|rcsb pdb:7KIA|rcsb pdb:7KIE|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-190375|reactome:R-HSA-5654700|reactome:R-HSA-5654727|reactome:R-HSA-5655253|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853333|reactome:R-HSA-190377|reactome:R-HSA-2023837|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-5654221|reactome:R-HSA-5654695|reactome:R-HSA-5654699|refseq:NP_001307583.1|refseq:NP_001307587.1|refseq:NP_075418.1|dip:DIP-3788N	-	-	-	figure legend:3A/B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/23	2014/10/16	-	rogid:XW6x8AHgdb29IL3MhUFWpv4jaqE9606	intact-crc:5687C933245EACDD	false	-	necessary binding region:255-366	1	1	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)