#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08670	uniprotkb:Q8UZC1	intact:EBI-353844|uniprotkb:Q15867|uniprotkb:Q15868|uniprotkb:Q15869|uniprotkb:Q548L2|uniprotkb:Q6LER9|uniprotkb:Q8N850|uniprotkb:Q96ML2|uniprotkb:Q9NTM3|uniprotkb:B0YJC2|intact:EBI-3442369|uniprotkb:D3DRU4|ensembl:ENSP00000224237|ensembl:ENSP00000446007	intact:EBI-6878727	psi-mi:vime_human(display_long)|uniprotkb:VIM(gene name)|psi-mi:VIM(display_short)	psi-mi:q8uzc1_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Gladue et al. (2013)	pubmed:23576498|imex:IM-20933	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6878980|imex:IM-20933-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003371.2|ensembl:ENSG00000026025(gene)|ensembl:ENST00000224237(transcript)|ensembl:ENST00000544301(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027699|interpro:IPR039008|mint:P08670|rcsb pdb:1GK4|rcsb pdb:1GK6|rcsb pdb:1GK7|rcsb pdb:3G1E|rcsb pdb:3KLT|rcsb pdb:3S4R|rcsb pdb:3SSU|rcsb pdb:3SWK|rcsb pdb:3TRT|rcsb pdb:3UF1|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4YPC|rcsb pdb:4YV3|rcsb pdb:5WHF|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6BIR|rcsb pdb:6YXK|reactome:R-HSA-264870|reactome:R-HSA-390522|reactome:R-HSA-6785807|reactome:R-HSA-9013422|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|refseq:XP_006717563.1|dip:DIP-32507N	interpro:IPR033703|interpro:IPR038765|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR029053|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043128|interpro:IPR037080|interpro:IPR043502|interpro:IPR043504|interpro:IPR044067	-	-	-	figure legend:1C and 3C|comment:"Transitory colocalization between 0.5 and 1.5 hpi, with vimentin forming a cage-like structure around 2C in all cells infected with FMDV. In presence of a dominant-negative vimentin construct (transfected HA-tagged deletion construct 1-134), the vimentin  cage was also formed after 0.5 hpi but remains unaltered at least until 4 hpi."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf10a)|taxid:9606(Human non-transformed breast epithelial cell line)	-	2013/07/04	2015/09/30	rogid:GhAhVuXMNxi6P5J0CfNi5l9bjRk9606	rogid:VxB8hCx/d8MkVcPkXGLwVyOEvcM12118	intact-crc:0CF0895ECC1AB76E|rigid:kab2GLyoSg+9K6bAS0ZSw7BXwXw	false	-	sufficient binding region:1108-1425	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P48616	uniprotkb:Q8UZC1	intact:EBI-1221453|uniprotkb:Q17QM7|ensembl:ENSBTAP00000024572	intact:EBI-6878727	psi-mi:vime_bovin(display_long)|uniprotkb:VIM(gene name)|psi-mi:VIM(display_short)	psi-mi:q8uzc1_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gladue et al. (2013)	pubmed:23576498|imex:IM-20933	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6878945|imex:IM-20933-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776394.2|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:1990254"(keratin filament binding)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027699|interpro:IPR039008|mint:P48616|reactome:R-BTA-264870|reactome:R-BTA-390522|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|ensembl:ENSBTAG00000018463(gene)|ensembl:ENSBTAT00000024572(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)	interpro:IPR033703|interpro:IPR038765|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR029053|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043128|interpro:IPR037080|interpro:IPR043502|interpro:IPR043504|interpro:IPR044067	-	-	-	figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/07/04	2015/09/30	rogid:oZXopQoyC/7xVtAjf3DgbSXiOo89913	rogid:VxB8hCx/d8MkVcPkXGLwVyOEvcM12118	intact-crc:8B4D63B9D4BAF556|rigid:AZxy2TiXpTRt5w1J5ZayMCzm4OY	false	-	sufficient binding region:1108-1425	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8UZC1	uniprotkb:P48616	intact:EBI-6878727	intact:EBI-1221453|uniprotkb:Q17QM7|ensembl:ENSBTAP00000024572	psi-mi:q8uzc1_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:vime_bovin(display_long)|uniprotkb:VIM(gene name)|psi-mi:VIM(display_short)	psi-mi:"MI:0018"(two hybrid)	Gladue et al. (2013)	pubmed:23576498|imex:IM-20933	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6878958|imex:IM-20933-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR033703|interpro:IPR038765|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR029053|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043128|interpro:IPR037080|interpro:IPR043502|interpro:IPR043504|interpro:IPR044067	refseq:NP_776394.2|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:1990254"(keratin filament binding)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027699|interpro:IPR039008|mint:P48616|reactome:R-BTA-264870|reactome:R-BTA-390522|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|ensembl:ENSBTAG00000018463(gene)|ensembl:ENSBTAT00000024572(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)	-	-	-	figure legend:1A and 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/07/04	2015/09/30	rogid:VxB8hCx/d8MkVcPkXGLwVyOEvcM12118	rogid:oZXopQoyC/7xVtAjf3DgbSXiOo89913	intact-crc:9BB0E5E61674E9DA|rigid:AZxy2TiXpTRt5w1J5ZayMCzm4OY	false	mutation disrupting interaction:1185-1191|mutation disrupting interaction:1192-1198|sufficient binding region:1108-1425	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q4A1L4	uniprotkb:Q8UZC1	intact:EBI-6874856|ensembl:ENSBTAP00000026531	intact:EBI-6878727	psi-mi:becn1_bovin(display_long)|uniprotkb:BECN1(gene name)|psi-mi:BECN1(display_short)	psi-mi:q8uzc1_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gladue et al. (2013)	pubmed:23576498|imex:IM-20933	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6878989|imex:IM-20933-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000019914(gene)|ensembl:ENSBTAT00000026531(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005634"(nucleus)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007049"(cell cycle)|go:"GO:0010008"(endosome membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|refseq:NP_001028799.1	interpro:IPR033703|interpro:IPR038765|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR029053|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043128|interpro:IPR037080|interpro:IPR043502|interpro:IPR043504|interpro:IPR044067	-	-	-	figure legend:5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/07/04	2015/09/30	rogid:o6bnoihEIY3bRzSPCH0rDAl+q1E9913	rogid:VxB8hCx/d8MkVcPkXGLwVyOEvcM12118	intact-crc:40D097D739853D77|rigid:pTjzAmXkAS1XO+G0E35Z4Ik+vTk	false	-	sufficient binding region:1108-1425	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08670	uniprotkb:Q8UZC1	intact:EBI-353844|uniprotkb:Q15867|uniprotkb:Q15868|uniprotkb:Q15869|uniprotkb:Q548L2|uniprotkb:Q6LER9|uniprotkb:Q8N850|uniprotkb:Q96ML2|uniprotkb:Q9NTM3|uniprotkb:B0YJC2|intact:EBI-3442369|uniprotkb:D3DRU4|ensembl:ENSP00000224237|ensembl:ENSP00000446007	intact:EBI-6878727	psi-mi:vime_human(display_long)|uniprotkb:VIM(gene name)|psi-mi:VIM(display_short)	psi-mi:q8uzc1_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gladue et al. (2013)	pubmed:23576498|imex:IM-20933	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6878969|imex:IM-20933-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003371.2|ensembl:ENSG00000026025(gene)|ensembl:ENST00000224237(transcript)|ensembl:ENST00000544301(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027699|interpro:IPR039008|mint:P08670|rcsb pdb:1GK4|rcsb pdb:1GK6|rcsb pdb:1GK7|rcsb pdb:3G1E|rcsb pdb:3KLT|rcsb pdb:3S4R|rcsb pdb:3SSU|rcsb pdb:3SWK|rcsb pdb:3TRT|rcsb pdb:3UF1|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4YPC|rcsb pdb:4YV3|rcsb pdb:5WHF|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6BIR|rcsb pdb:6YXK|reactome:R-HSA-264870|reactome:R-HSA-390522|reactome:R-HSA-6785807|reactome:R-HSA-9013422|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|refseq:XP_006717563.1|dip:DIP-32507N	interpro:IPR033703|interpro:IPR038765|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR029053|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043128|interpro:IPR037080|interpro:IPR043502|interpro:IPR043504|interpro:IPR044067	-	-	-	figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf10a)|taxid:9606(Human non-transformed breast epithelial cell line)	-	2013/07/04	2015/09/30	rogid:GhAhVuXMNxi6P5J0CfNi5l9bjRk9606	rogid:VxB8hCx/d8MkVcPkXGLwVyOEvcM12118	intact-crc:8406CEDF4B51603F|rigid:kab2GLyoSg+9K6bAS0ZSw7BXwXw	false	-	sufficient binding region:1108-1425	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)