#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q86WV6	uniprotkb:Q99IB8-PRO_0000045601	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	intact:EBI-6928570|intact:EBI-8786387	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:q99ib8-pro_0000045601(display_long)	psi-mi:"MI:0663"(confocal microscopy)	Ding et al. (2013)	pubmed:23542348|imex:IM-25972	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8786474|imex:IM-25972-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	intact:EBI-6674379(chain-parent)	-	-	chain-seq-start:1716|chain-seq-end:1976	figure legend:Fig. 2D|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ph5ch8)|taxid:9606(Human primary  hepatocyte ph5ch8)	-	2013/10/02	2014/10/16	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	rogid:9V9Qr4j9EH+1xmq3GXm39eFxJYU356411	intact-crc:8FB05850DDD4CC56|rigid:rfeqeJZ0HHIwXf23mcbZqvMHs4Y	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q86WV6	uniprotkb:Q99IB8-PRO_0000045601	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	intact:EBI-6928570|intact:EBI-8786387	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:q99ib8-pro_0000045601(display_long)	psi-mi:"MI:0663"(confocal microscopy)	Ding et al. (2013)	pubmed:23542348|imex:IM-25972	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8786506|imex:IM-25972-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	intact:EBI-6674379(chain-parent)	-	-	chain-seq-start:1716|chain-seq-end:1976	figure legend:Fig. 2E|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma)	-	2013/10/02	2014/10/16	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	rogid:9V9Qr4j9EH+1xmq3GXm39eFxJYU356411	intact-crc:51C5075D4AC249FB|rigid:rfeqeJZ0HHIwXf23mcbZqvMHs4Y	false	myc tag:?-?	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q86WV6	uniprotkb:Q86WV6	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ding et al. (2013)	pubmed:23542348|imex:IM-25972	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8803392|imex:IM-25972-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	-	-	-	figure legend:Fig. 3B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ph5ch8)|taxid:9606(Human primary  hepatocyte ph5ch8)	-	2013/10/02	2014/10/16	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:38A0E72ACBE5F567|rigid:+mlOKqwlhB6E8y9QKfvh9CE/7U4	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7Z434	uniprotkb:Q86WV6	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ding et al. (2013)	pubmed:23542348|imex:IM-25972	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8803363|imex:IM-25972-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	-	-	-	figure legend:Fig. 3C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ph5ch8)|taxid:9606(Human primary  hepatocyte ph5ch8)	-	2013/10/02	2014/10/16	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:7C3A792DBF2B65AB|rigid:CDRk7atfKKZg4F/5mVK7/Ndybzg	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q86WV6	uniprotkb:Q99IB8-PRO_0000045601	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	intact:EBI-6928570|intact:EBI-8786387	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:q99ib8-pro_0000045601(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ding et al. (2013)	pubmed:23542348|imex:IM-25972	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8803365|imex:IM-25972-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	intact:EBI-6674379(chain-parent)	-	-	chain-seq-start:1716|chain-seq-end:1976	figure legend:Fig. 2C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ph5ch8)|taxid:9606(Human primary  hepatocyte ph5ch8)	-	2013/10/02	2017/09/02	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	rogid:9V9Qr4j9EH+1xmq3GXm39eFxJYU356411	intact-crc:5D88044B512F4D53|rigid:rfeqeJZ0HHIwXf23mcbZqvMHs4Y	false	-	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UHD2	uniprotkb:Q86WV6	intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ding et al. (2013)	pubmed:23542348|imex:IM-25972	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8803367|imex:IM-25972-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	-	-	-	figure legend:Fig. 3D|comment:NS4B inhibit TBK1-STING interaction|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ph5ch8)|taxid:9606(Human primary  hepatocyte ph5ch8)	-	2013/10/02	2014/10/16	rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:23528E922EA3E031|rigid:ekEgIYjA7SkzHrlL1HX9AXbb3FE	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UHD2	uniprotkb:Q86WV6	intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ding et al. (2013)	pubmed:23542348|imex:IM-25972	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8786411|imex:IM-25972-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	-	-	-	figure legend:Supp. fig. 2|comment:NS4B inhibit TBK1-STING interaction|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293a)|taxid:9606(Homo sapiens)	-	2013/10/02	2017/09/02	rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:303626535F83321F|rigid:ekEgIYjA7SkzHrlL1HX9AXbb3FE	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7Z434	uniprotkb:Q86WV6	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ding et al. (2013)	pubmed:23542348|imex:IM-25972	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8786401|imex:IM-25972-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	-	-	-	figure legend:Supp. fig. 2|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293a)|taxid:9606(Homo sapiens)	-	2013/10/02	2017/09/02	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:299D0959EFA22D9C|rigid:CDRk7atfKKZg4F/5mVK7/Ndybzg	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q86WV6	uniprotkb:Q99IB8-PRO_0000045601	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	intact:EBI-6928570|intact:EBI-8786387	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:q99ib8-pro_0000045601(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ding et al. (2013)	pubmed:23542348|imex:IM-25972	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8786385|imex:IM-25972-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	intact:EBI-6674379(chain-parent)	-	-	chain-seq-start:1716|chain-seq-end:1976	figure legend:Fig. 2A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293a)|taxid:9606(Homo sapiens)	-	2013/10/02	2017/09/02	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	rogid:9V9Qr4j9EH+1xmq3GXm39eFxJYU356411	intact-crc:AC78D1DFD0B73FC1|rigid:rfeqeJZ0HHIwXf23mcbZqvMHs4Y	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q86WV6	uniprotkb:Q86WV6	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ding et al. (2013)	pubmed:23542348|imex:IM-25972	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8803345|imex:IM-25972-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	-	-	-	figure legend:Supp. fig. 2B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293a)|taxid:9606(Homo sapiens)	-	2013/10/02	2017/09/02	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	intact-crc:D04C521F4A57A76F|rigid:+mlOKqwlhB6E8y9QKfvh9CE/7U4	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q86WV6	uniprotkb:Q99IB8-PRO_0000045601	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	intact:EBI-6928570|intact:EBI-8786387	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:q99ib8-pro_0000045601(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ding et al. (2013)	pubmed:23542348|imex:IM-25972	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-8786435|imex:IM-25972-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	intact:EBI-6674379(chain-parent)	-	-	chain-seq-start:1716|chain-seq-end:1976	figure legend:Fig. 2C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ph5ch8)|taxid:9606(Human primary  hepatocyte ph5ch8)	-	2013/10/02	2017/09/02	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	rogid:9V9Qr4j9EH+1xmq3GXm39eFxJYU356411	intact-crc:A9FEF439C736798C|rigid:rfeqeJZ0HHIwXf23mcbZqvMHs4Y	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)