#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P51608	uniprotkb:Q61687	intact:EBI-1189067|uniprotkb:O15233|uniprotkb:Q6QHH9|uniprotkb:Q7Z384|ensembl:ENSP00000301948	intact:EBI-2657527|intact:EBI-2658449|uniprotkb:A2ADH4|ensembl:ENSMUSP00000109203	psi-mi:mecp2_human(display_long)|uniprotkb:MECP2(gene name)|psi-mi:MECP2(display_short)	psi-mi:atrx_mouse(display_long)|uniprotkb:Xnp(gene name synonym)|uniprotkb:ATP-dependent helicase ATRX(gene name synonym)|uniprotkb:HP1 alpha-interacting protein(gene name synonym)|uniprotkb:HP1-BP38 protein(gene name synonym)|uniprotkb:Heterochromatin protein 2(gene name synonym)|uniprotkb:X-linked nuclear protein(gene name synonym)|uniprotkb:Atrx(gene name)|psi-mi:Atrx(display_short)|uniprotkb:Hp1bp2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Baker et al. (2013)	pubmed:23452848|imex:IM-20940	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6879888|imex:IM-20940-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104262.1|refseq:NP_004983.1|refseq:NP_001303266.1|ensembl:ENSG00000169057(gene)|ensembl:ENST00000303391(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0042551"(neuron maturation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:P51608|rcsb pdb:1QK9|rcsb pdb:3C2I|rcsb pdb:5BT2|rcsb pdb:6C1Y|rcsb pdb:6OGJ|rcsb pdb:6OGK|reactome:R-HSA-8986944|reactome:R-HSA-9022534|reactome:R-HSA-9022535|reactome:R-HSA-9022537|reactome:R-HSA-9022538|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9022702|reactome:R-HSA-9022707|reactome:R-HSA-9022927|dip:DIP-39983N	refseq:NP_033556.2|interpro:IPR038718|interpro:IPR041430|mint:Q61687|reactome:R-MMU-9670095|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900112"(regulation of histone H3-K9 trimethylation)|go:"GO:1901581"(negative regulation of telomeric RNA transcription from RNA pol II promoter)|go:"GO:1901582"(positive regulation of telomeric RNA transcription from RNA pol II promoter)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR025766|interpro:IPR027417|ensembl:ENSMUSG00000031229(gene)|ensembl:ENSMUST00000113573(transcript)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|go:"GO:0015616"(DNA translocase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030900"(forebrain development)|go:"GO:0031297"(replication fork processing)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035128"(post-embryonic forelimb morphogenesis)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070615"|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0072711"(cellular response to hydroxyurea)|dip:DIP-55974N	-	-	-	figure legend:Supp. Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2013/07/05	2014/10/16	rogid:7c5ZZAZsqV7AciGN4hzFNWJLeUk9606	rogid:dZfE7Or8WAgkuHkmUcqC3UlWi7U10090	intact-crc:16061DFFE588DF67|rigid:5/DDND+DKSAzYkTHzn8cUX+IpqY	false	green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-8756580	uniprotkb:P51608	-	intact:EBI-1189067|uniprotkb:O15233|uniprotkb:Q6QHH9|uniprotkb:Q7Z384|ensembl:ENSP00000301948	psi-mi:64mer_ds_dna_probe(display_short)|psi-mi:EBI-8756580(display_long)	psi-mi:mecp2_human(display_long)|uniprotkb:MECP2(gene name)|psi-mi:MECP2(display_short)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Baker et al. (2013)	pubmed:23452848|imex:IM-20940	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8756596|imex:IM-20940-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001104262.1|refseq:NP_004983.1|refseq:NP_001303266.1|ensembl:ENSG00000169057(gene)|ensembl:ENST00000303391(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0042551"(neuron maturation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:P51608|rcsb pdb:1QK9|rcsb pdb:3C2I|rcsb pdb:5BT2|rcsb pdb:6C1Y|rcsb pdb:6OGJ|rcsb pdb:6OGK|reactome:R-HSA-8986944|reactome:R-HSA-9022534|reactome:R-HSA-9022535|reactome:R-HSA-9022537|reactome:R-HSA-9022538|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9022702|reactome:R-HSA-9022707|reactome:R-HSA-9022927|dip:DIP-39983N	-	-	-	figure legend:Fig. 5C, Supp. Fig. 5E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.6x10^-6(molar)	2013/07/05	2014/10/16	-	rogid:7c5ZZAZsqV7AciGN4hzFNWJLeUk9606	intact-crc:FDCAC509026C3689	false	-	necessary binding region:270-272|sufficient binding region:257-272(IPR017956)|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)