#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P27958-PRO_0000037576 uniprotkb:Q9Z2A7 intact:EBI-8753518 intact:EBI-8763397|uniprotkb:Q9D7Q5|ensembl:ENSMUSP00000023214 psi-mi:p27958-pro_0000037576(display_long) psi-mi:dgat1_mouse(display_long)|uniprotkb:Dgat1(gene name)|psi-mi:Dgat1(display_short)|uniprotkb:Dgat(gene name synonym)|uniprotkb:Acyl-CoA retinol O-fatty-acyltransferase(gene name synonym)|uniprotkb:Diglyceride acyltransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Camus et al. (2013) pubmed:23420847|imex:IM-25909 taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8763431|imex:IM-25909-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-706378(chain-parent) refseq:NP_034176.1|ensembl:ENSMUSG00000022555(gene)|ensembl:ENSMUST00000023214(transcript)|go:"GO:0003846"(2-acylglycerol O-acyltransferase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0019915"(lipid storage)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0035336"(long-chain fatty-acyl-CoA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0046486"(glycerolipid metabolic process)|go:"GO:0050252"(retinol O-fatty-acyltransferase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:1901738"(regulation of vitamin A metabolic process)|go:"GO:1902224"(ketone body metabolic process)|go:"GO:1903998"(regulation of eating behavior)|go:"GO:1904729"(regulation of intestinal lipid absorption)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|interpro:IPR004299(Membrane bound O-acyl transferase, MBOAT)|interpro:IPR014371(Sterol O-acyltransferase, ACAT/DAG/ARE types)|interpro:IPR027251|reactome:R-MMU-1482883|reactome:R-MMU-6798695|reactome:R-MMU-75109 go:"GO:0005811"(lipid droplet) chain-seq-start:1973|chain-seq-end:2420 - figure legend:Fig. 1B, 6A and 6B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2013/09/02 2017/09/02 rogid:QUtsxvdJhyaJg2Xu4JFrW5Tay2A63746 rogid:ZPRV18n+94gvRBi2NnMThgVf+Cs10090 intact-crc:CCEA0264F4434E19|rigid:OLzYZK8DduuPdu6edAURz13gSe8 false green fluorescent protein tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O75907 uniprotkb:Q99IB8-PRO_0000045592 intact:EBI-3906527|uniprotkb:D3DWL6|uniprotkb:B2RWQ2|uniprotkb:Q96BB8|ensembl:ENSP00000482264|ensembl:ENSP00000495489 intact:EBI-6858513|intact:EBI-6929338 psi-mi:dgat1_human(display_long)|uniprotkb:DGAT1(gene name)|psi-mi:DGAT1(display_short)|uniprotkb:AGRP1(gene name synonym)|uniprotkb:DGAT(gene name synonym)|uniprotkb:ACAT-related gene product 1(gene name synonym)|uniprotkb:Diglyceride acyltransferase(gene name synonym)|uniprotkb:Acyl-CoA retinol O-fatty-acyltransferase(gene name synonym) psi-mi:q99ib8-pro_0000045592(display_long) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Camus et al. (2013) pubmed:23420847|imex:IM-25909 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8764433|imex:IM-25909-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036211.2|ensembl:ENSG00000185000(gene)|ensembl:ENSG00000285482(gene)|ensembl:ENST00000528718(transcript)|ensembl:ENST00000644790(transcript)|go:"GO:0003846"(2-acylglycerol O-acyltransferase activity)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0019915"(lipid storage)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0035336"(long-chain fatty-acyl-CoA metabolic process)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0050252"(retinol O-fatty-acyltransferase activity)|go:"GO:0055089"(fatty acid homeostasis)|interpro:IPR004299(Membrane bound O-acyl transferase, MBOAT)|interpro:IPR014371(Sterol O-acyltransferase, ACAT/DAG/ARE types)|interpro:IPR027251|mint:O75907|rcsb pdb:6VP0|rcsb pdb:6VYI|rcsb pdb:6VZ1|reactome:R-HSA-1482883|reactome:R-HSA-6798695|reactome:R-HSA-75109 intact:EBI-6674379(chain-parent) go:"GO:0005811"(lipid droplet) - chain-seq-start:2|chain-seq-end:191 figure legend:Fig. 1A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2013/09/02 2017/09/02 rogid:21iLqDiwzbSaVWIXFPlV5GjbRgY9606 rogid:IvCIliS0Wa+ryvS2l1H9PDAun94356411 intact-crc:B4D84EE1CCCDBC0C|rigid:AUNXkuxY2Yyks5CLFzEbD5TIbdE false - flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q99IB8-PRO_0000045602 uniprotkb:O75907 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 intact:EBI-3906527|uniprotkb:D3DWL6|uniprotkb:B2RWQ2|uniprotkb:Q96BB8|ensembl:ENSP00000482264|ensembl:ENSP00000495489 psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:dgat1_human(display_long)|uniprotkb:DGAT1(gene name)|psi-mi:DGAT1(display_short)|uniprotkb:AGRP1(gene name synonym)|uniprotkb:DGAT(gene name synonym)|uniprotkb:ACAT-related gene product 1(gene name synonym)|uniprotkb:Diglyceride acyltransferase(gene name synonym)|uniprotkb:Acyl-CoA retinol O-fatty-acyltransferase(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Camus et al. (2013) pubmed:23420847|imex:IM-25909 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8753500|imex:IM-25909-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) refseq:NP_036211.2|ensembl:ENSG00000185000(gene)|ensembl:ENSG00000285482(gene)|ensembl:ENST00000528718(transcript)|ensembl:ENST00000644790(transcript)|go:"GO:0003846"(2-acylglycerol O-acyltransferase activity)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0019915"(lipid storage)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0035336"(long-chain fatty-acyl-CoA metabolic process)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0050252"(retinol O-fatty-acyltransferase activity)|go:"GO:0055089"(fatty acid homeostasis)|interpro:IPR004299(Membrane bound O-acyl transferase, MBOAT)|interpro:IPR014371(Sterol O-acyltransferase, ACAT/DAG/ARE types)|interpro:IPR027251|mint:O75907|rcsb pdb:6VP0|rcsb pdb:6VYI|rcsb pdb:6VZ1|reactome:R-HSA-1482883|reactome:R-HSA-6798695|reactome:R-HSA-75109 - chain-seq-start:1977|chain-seq-end:2442 - figure legend:Fig. 1A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2013/09/02 2017/09/02 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 rogid:21iLqDiwzbSaVWIXFPlV5GjbRgY9606 intact-crc:4D4186A0BB30A596|rigid:UbV0wid9pLDRbXbU7QwWxT7DVlM false flag tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O75907 uniprotkb:Q99IB8-PRO_0000045602 intact:EBI-3906527|uniprotkb:D3DWL6|uniprotkb:B2RWQ2|uniprotkb:Q96BB8|ensembl:ENSP00000482264|ensembl:ENSP00000495489 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 psi-mi:dgat1_human(display_long)|uniprotkb:DGAT1(gene name)|psi-mi:DGAT1(display_short)|uniprotkb:AGRP1(gene name synonym)|uniprotkb:DGAT(gene name synonym)|uniprotkb:ACAT-related gene product 1(gene name synonym)|uniprotkb:Diglyceride acyltransferase(gene name synonym)|uniprotkb:Acyl-CoA retinol O-fatty-acyltransferase(gene name synonym) psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Camus et al. (2013) pubmed:23420847|imex:IM-25909 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8764470|imex:IM-25909-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036211.2|ensembl:ENSG00000185000(gene)|ensembl:ENSG00000285482(gene)|ensembl:ENST00000528718(transcript)|ensembl:ENST00000644790(transcript)|go:"GO:0003846"(2-acylglycerol O-acyltransferase activity)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0019915"(lipid storage)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0035336"(long-chain fatty-acyl-CoA metabolic process)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0050252"(retinol O-fatty-acyltransferase activity)|go:"GO:0055089"(fatty acid homeostasis)|interpro:IPR004299(Membrane bound O-acyl transferase, MBOAT)|interpro:IPR014371(Sterol O-acyltransferase, ACAT/DAG/ARE types)|interpro:IPR027251|mint:O75907|rcsb pdb:6VP0|rcsb pdb:6VYI|rcsb pdb:6VZ1|reactome:R-HSA-1482883|reactome:R-HSA-6798695|reactome:R-HSA-75109 intact:EBI-6674379(chain-parent) - - chain-seq-start:1977|chain-seq-end:2442 figure legend:Fig. 1C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2013/09/02 2017/09/02 rogid:21iLqDiwzbSaVWIXFPlV5GjbRgY9606 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 intact-crc:4392BB0F3A52CDB7|rigid:UbV0wid9pLDRbXbU7QwWxT7DVlM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q99IB8-PRO_0000045592 uniprotkb:P27958-PRO_0000037576 intact:EBI-6858513|intact:EBI-6929338 intact:EBI-8753518 psi-mi:q99ib8-pro_0000045592(display_long) psi-mi:p27958-pro_0000037576(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Camus et al. (2013) pubmed:23420847|imex:IM-25909 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8763465|imex:IM-25909-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) intact:EBI-706378(chain-parent) - chain-seq-start:2|chain-seq-end:191 chain-seq-start:1973|chain-seq-end:2420 figure legend:FIg. 2A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/09/02 2017/09/02 rogid:IvCIliS0Wa+ryvS2l1H9PDAun94356411 rogid:QUtsxvdJhyaJg2Xu4JFrW5Tay2A63746 intact-crc:0814CC3BF560F581|rigid:ZH35J114ahUoL4g2ik+l8+BCbsc false ha tag:?-? green fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q99IB8-PRO_0000045592 uniprotkb:P27958-PRO_0000037576 intact:EBI-6858513|intact:EBI-6929338 intact:EBI-8753518 psi-mi:q99ib8-pro_0000045592(display_long) psi-mi:p27958-pro_0000037576(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Camus et al. (2013) pubmed:23420847|imex:IM-25909 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8753545|imex:IM-25909-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) intact:EBI-706378(chain-parent) - chain-seq-start:2|chain-seq-end:191 chain-seq-start:1973|chain-seq-end:2420 figure legend:FIg. 2A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/09/02 2017/09/02 rogid:IvCIliS0Wa+ryvS2l1H9PDAun94356411 rogid:QUtsxvdJhyaJg2Xu4JFrW5Tay2A63746 intact-crc:54E700EF88328BC3|rigid:ZH35J114ahUoL4g2ik+l8+BCbsc false ha tag:?-? green fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q99IB8-PRO_0000045592 uniprotkb:Q9Z2A7 intact:EBI-6858513|intact:EBI-6929338 intact:EBI-8763397|uniprotkb:Q9D7Q5|ensembl:ENSMUSP00000023214 psi-mi:q99ib8-pro_0000045592(display_long) psi-mi:dgat1_mouse(display_long)|uniprotkb:Dgat1(gene name)|psi-mi:Dgat1(display_short)|uniprotkb:Dgat(gene name synonym)|uniprotkb:Acyl-CoA retinol O-fatty-acyltransferase(gene name synonym)|uniprotkb:Diglyceride acyltransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Camus et al. (2013) pubmed:23420847|imex:IM-25909 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8753555|imex:IM-25909-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) refseq:NP_034176.1|ensembl:ENSMUSG00000022555(gene)|ensembl:ENSMUST00000023214(transcript)|go:"GO:0003846"(2-acylglycerol O-acyltransferase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0019915"(lipid storage)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0035336"(long-chain fatty-acyl-CoA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0046486"(glycerolipid metabolic process)|go:"GO:0050252"(retinol O-fatty-acyltransferase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:1901738"(regulation of vitamin A metabolic process)|go:"GO:1902224"(ketone body metabolic process)|go:"GO:1903998"(regulation of eating behavior)|go:"GO:1904729"(regulation of intestinal lipid absorption)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|interpro:IPR004299(Membrane bound O-acyl transferase, MBOAT)|interpro:IPR014371(Sterol O-acyltransferase, ACAT/DAG/ARE types)|interpro:IPR027251|reactome:R-MMU-1482883|reactome:R-MMU-6798695|reactome:R-MMU-75109 - chain-seq-start:2|chain-seq-end:191 - figure legend:FIg. 2A and 2B|comment:Tandem immunoprecipitations were performed with α-FLAG M2 affinity gel and α-HA antibody-conjugated agarose. α-FLAG M2 affinity gel was eluted with FLAG peptide, and the eluates were incubated with α-HA antibody-conjugated agarose.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/09/02 2017/09/02 rogid:IvCIliS0Wa+ryvS2l1H9PDAun94356411 rogid:ZPRV18n+94gvRBi2NnMThgVf+Cs10090 intact-crc:B2469EC8F21A6163|rigid:lnLrE4aXpKhAJbrAOJChmNOt9ZM false ha tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q99IB8-PRO_0000045592 uniprotkb:P27958-PRO_0000037576 intact:EBI-6858513|intact:EBI-6929338 intact:EBI-8753518 psi-mi:q99ib8-pro_0000045592(display_long) psi-mi:p27958-pro_0000037576(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Camus et al. (2013) pubmed:23420847|imex:IM-25909 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-8753555|imex:IM-25909-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) intact:EBI-706378(chain-parent) - chain-seq-start:2|chain-seq-end:191 chain-seq-start:1973|chain-seq-end:2420 figure legend:FIg. 2A and 2B|comment:Tandem immunoprecipitations were performed with α-FLAG M2 affinity gel and α-HA antibody-conjugated agarose. α-FLAG M2 affinity gel was eluted with FLAG peptide, and the eluates were incubated with α-HA antibody-conjugated agarose.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2013/09/02 2017/09/02 rogid:IvCIliS0Wa+ryvS2l1H9PDAun94356411 rogid:QUtsxvdJhyaJg2Xu4JFrW5Tay2A63746 intact-crc:B2469EC8F21A6163|rigid:lnLrE4aXpKhAJbrAOJChmNOt9ZM false ha tag:?-? green fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Z2A7 uniprotkb:Q99IB8-PRO_0000045602 intact:EBI-8763397|uniprotkb:Q9D7Q5|ensembl:ENSMUSP00000023214 intact:EBI-6927873|intact:EBI-9232975|intact:EBI-6931023 psi-mi:dgat1_mouse(display_long)|uniprotkb:Dgat1(gene name)|psi-mi:Dgat1(display_short)|uniprotkb:Dgat(gene name synonym)|uniprotkb:Acyl-CoA retinol O-fatty-acyltransferase(gene name synonym)|uniprotkb:Diglyceride acyltransferase(gene name synonym) psi-mi:q99ib8-pro_0000045602(display_long) psi-mi:"MI:0416"(fluorescence microscopy) Camus et al. (2013) pubmed:23420847|imex:IM-25909 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1335"(HPIDb) intact:EBI-8753582|imex:IM-25909-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034176.1|ensembl:ENSMUSG00000022555(gene)|ensembl:ENSMUST00000023214(transcript)|go:"GO:0003846"(2-acylglycerol O-acyltransferase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0019915"(lipid storage)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0035336"(long-chain fatty-acyl-CoA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0046486"(glycerolipid metabolic process)|go:"GO:0050252"(retinol O-fatty-acyltransferase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:1901738"(regulation of vitamin A metabolic process)|go:"GO:1902224"(ketone body metabolic process)|go:"GO:1903998"(regulation of eating behavior)|go:"GO:1904729"(regulation of intestinal lipid absorption)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|interpro:IPR004299(Membrane bound O-acyl transferase, MBOAT)|interpro:IPR014371(Sterol O-acyltransferase, ACAT/DAG/ARE types)|interpro:IPR027251|reactome:R-MMU-1482883|reactome:R-MMU-6798695|reactome:R-MMU-75109 intact:EBI-6674379(chain-parent) go:"GO:0005811"(lipid droplet) - chain-seq-start:1977|chain-seq-end:2442 figure legend:Fig. 6D|comment:"DGAT1 mutant (his426ala) interacted with NS5A with similar affinity to wild-type but suppressed NS5A translocation to lipid droplets."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2013/09/02 2014/10/16 rogid:ZPRV18n+94gvRBi2NnMThgVf+Cs10090 rogid:qAEcnahT9EPJdIQhjuLxeAPuJ+M356411 intact-crc:77FA0EC95FEF2244|rigid:N+IEHbPj6d0eaetXvWtSeHQDWY0 false flag tag:?-? green fluorescent protein tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q99IB8-PRO_0000045592 uniprotkb:Q9Z2A7 intact:EBI-6858513|intact:EBI-6929338 intact:EBI-8763397|uniprotkb:Q9D7Q5|ensembl:ENSMUSP00000023214 psi-mi:q99ib8-pro_0000045592(display_long) psi-mi:dgat1_mouse(display_long)|uniprotkb:Dgat1(gene name)|psi-mi:Dgat1(display_short)|uniprotkb:Dgat(gene name synonym)|uniprotkb:Acyl-CoA retinol O-fatty-acyltransferase(gene name synonym)|uniprotkb:Diglyceride acyltransferase(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Camus et al. (2013) pubmed:23420847|imex:IM-25909 taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1335"(HPIDb) intact:EBI-8753594|imex:IM-25909-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6674379(chain-parent) refseq:NP_034176.1|ensembl:ENSMUSG00000022555(gene)|ensembl:ENSMUST00000023214(transcript)|go:"GO:0003846"(2-acylglycerol O-acyltransferase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0019915"(lipid storage)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0035336"(long-chain fatty-acyl-CoA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0046486"(glycerolipid metabolic process)|go:"GO:0050252"(retinol O-fatty-acyltransferase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:1901738"(regulation of vitamin A metabolic process)|go:"GO:1902224"(ketone body metabolic process)|go:"GO:1903998"(regulation of eating behavior)|go:"GO:1904729"(regulation of intestinal lipid absorption)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|interpro:IPR004299(Membrane bound O-acyl transferase, MBOAT)|interpro:IPR014371(Sterol O-acyltransferase, ACAT/DAG/ARE types)|interpro:IPR027251|reactome:R-MMU-1482883|reactome:R-MMU-6798695|reactome:R-MMU-75109 go:"GO:0005811"(lipid droplet) chain-seq-start:2|chain-seq-end:191 - figure legend:Fig. 6E|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2013/09/02 2017/09/02 rogid:IvCIliS0Wa+ryvS2l1H9PDAun94356411 rogid:ZPRV18n+94gvRBi2NnMThgVf+Cs10090 intact-crc:1696FC8AD8C969D3|rigid:vFUtn3NyOpfgwZ5u7DGMqL0X/xM false - flag tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)