#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q10567	uniprotkb:P22892	intact:EBI-1171303|uniprotkb:P78436|uniprotkb:C9JRD1|uniprotkb:Q20WL3|intact:EBI-11577132|uniprotkb:F8WDL0|uniprotkb:Q86X54|ensembl:ENSP00000319361|ensembl:ENSP00000350199|ensembl:ENSP00000384194|ensembl:ENSP00000400065	intact:EBI-1040262|ensembl:ENSMUSP00000034171	psi-mi:ap1b1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit beta-1(gene name synonym)|uniprotkb:Beta-adaptin 1(gene name synonym)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta large chain(gene name synonym)|uniprotkb:AP1B1(gene name)|psi-mi:AP1B1(display_short)|uniprotkb:ADTB1(gene name synonym)|uniprotkb:BAM22(gene name synonym)|uniprotkb:CLAPB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit beta-1(gene name synonym)	psi-mi:ap1g1_mouse(display_long)|uniprotkb:Ap1g1(gene name)|psi-mi:Ap1g1(display_short)|uniprotkb:Adtg(gene name synonym)|uniprotkb:Clapg1(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6863559|wwpdb:4HMY|imex:IM-20905-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001118.3|refseq:NP_663782.2|refseq:NP_001159491.1|ensembl:ENSG00000100280(gene)|ensembl:ENST00000317368(transcript)|ensembl:ENST00000357586(transcript)|ensembl:ENST00000405198(transcript)|ensembl:ENST00000432560(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q10567|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|rcsb pdb:6CRI|dip:DIP-24207N	refseq:NP_001288140.1|ensembl:ENSMUSG00000031731(gene)|ensembl:ENSMUST00000034171(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005518"(collagen binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:P22892|rcsb pdb:1GYU|rcsb pdb:1GYV|rcsb pdb:1GYW|rcsb pdb:1W63|rcsb pdb:2A7B|rcsb pdb:3ZY7|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|go:"GO:0015630"(microtubule cytoskeleton)	-	-	-	figure legend:Supp. Table 1|3d-r-factors:Rworking = 0.2 Rfree = 0.25|3d-resolution:7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/18	2016/02/11	rogid:D0i+5PXwzbBmOSyeCOSFKZx8fQk9606	rogid:VeKvrfk0rSWIQfepmlhaOm293MI10090	intact-crc:059F098F665A4A50|rigid:6fCUrC1AMiQgmmhxIhf3MSKBnoo	false	sufficient binding region:1-584|mutation:488-488	sufficient binding region:1-595	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q10567	uniprotkb:P35585	intact:EBI-1171303|uniprotkb:P78436|uniprotkb:C9JRD1|uniprotkb:Q20WL3|intact:EBI-11577132|uniprotkb:F8WDL0|uniprotkb:Q86X54|ensembl:ENSP00000319361|ensembl:ENSP00000350199|ensembl:ENSP00000384194|ensembl:ENSP00000400065	intact:EBI-1040251|ensembl:ENSMUSP00000003117	psi-mi:ap1b1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit beta-1(gene name synonym)|uniprotkb:Beta-adaptin 1(gene name synonym)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta large chain(gene name synonym)|uniprotkb:AP1B1(gene name)|psi-mi:AP1B1(display_short)|uniprotkb:ADTB1(gene name synonym)|uniprotkb:BAM22(gene name synonym)|uniprotkb:CLAPB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit beta-1(gene name synonym)	psi-mi:ap1m1_mouse(display_long)|uniprotkb:Ap1m1(gene name)|psi-mi:Ap1m1(display_short)|uniprotkb:Cltnm(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin mu-1 subunit(gene name synonym)|uniprotkb:Mu-adaptin 1(gene name synonym)|uniprotkb:AP-mu chain family member mu1A(gene name synonym)|uniprotkb:Mu1A-adaptin(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP47(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP47(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit mu-1(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 mu-1 medium chain 1(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit mu-1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6863559|wwpdb:4HMY|imex:IM-20905-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001118.3|refseq:NP_663782.2|refseq:NP_001159491.1|ensembl:ENSG00000100280(gene)|ensembl:ENST00000317368(transcript)|ensembl:ENST00000357586(transcript)|ensembl:ENST00000405198(transcript)|ensembl:ENST00000432560(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q10567|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|rcsb pdb:6CRI|dip:DIP-24207N	refseq:NP_031482.1|ensembl:ENSMUSG00000003033(gene)|ensembl:ENSMUST00000003117(transcript)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032438"(melanosome organization)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR028565|interpro:IPR036168|mint:P35585|rcsb pdb:1W63|rcsb pdb:4EMZ|rcsb pdb:4EN2|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-6798695|dip:DIP-35323N	-	-	-	figure legend:Supp. Table 1|3d-r-factors:Rworking = 0.2 Rfree = 0.25|3d-resolution:7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/18	2016/02/11	rogid:D0i+5PXwzbBmOSyeCOSFKZx8fQk9606	rogid:jng3stxfxbi8Emuhlquac0/JC0Q10090	intact-crc:059F098F665A4A50|rigid:6fCUrC1AMiQgmmhxIhf3MSKBnoo	false	sufficient binding region:1-584|mutation:488-488	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q10567	uniprotkb:Q96PC3	intact:EBI-1171303|uniprotkb:P78436|uniprotkb:C9JRD1|uniprotkb:Q20WL3|intact:EBI-11577132|uniprotkb:F8WDL0|uniprotkb:Q86X54|ensembl:ENSP00000319361|ensembl:ENSP00000350199|ensembl:ENSP00000384194|ensembl:ENSP00000400065	intact:EBI-3923129|uniprotkb:Q8WTY1|uniprotkb:Q96DD1|uniprotkb:B4DQZ1|ensembl:ENSP00000388738	psi-mi:ap1b1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit beta-1(gene name synonym)|uniprotkb:Beta-adaptin 1(gene name synonym)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta large chain(gene name synonym)|uniprotkb:AP1B1(gene name)|psi-mi:AP1B1(display_short)|uniprotkb:ADTB1(gene name synonym)|uniprotkb:BAM22(gene name synonym)|uniprotkb:CLAPB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit beta-1(gene name synonym)	psi-mi:ap1s3_human(display_long)|uniprotkb:AP1S3(gene name)|psi-mi:AP1S3(display_short)|uniprotkb:Clathrin assembly protein complex 1 sigma-1C small chain(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin sigma-1C subunit(gene name synonym)|uniprotkb:Sigma 1C subunit of AP-1 clathrin(gene name synonym)|uniprotkb:Sigma-adaptin 1C(gene name synonym)|uniprotkb:Sigma1C-adaptin(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit sigma-1C(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit sigma-1C(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6863559|wwpdb:4HMY|imex:IM-20905-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001118.3|refseq:NP_663782.2|refseq:NP_001159491.1|ensembl:ENSG00000100280(gene)|ensembl:ENST00000317368(transcript)|ensembl:ENST00000357586(transcript)|ensembl:ENST00000405198(transcript)|ensembl:ENST00000432560(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q10567|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|rcsb pdb:6CRI|dip:DIP-24207N	refseq:NP_001034658.1|ensembl:ENSG00000152056(gene)|ensembl:ENST00000446015(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006605"(protein targeting)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR044733|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|go:"GO:0005829"(cytosol)|reactome:R-HSA-432722	-	-	-	figure legend:Supp. Table 1|3d-r-factors:Rworking = 0.2 Rfree = 0.25|3d-resolution:7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/18	2016/02/11	rogid:D0i+5PXwzbBmOSyeCOSFKZx8fQk9606	rogid:4mRBQXekmJl9Ln+Bfq+jJbSkD409606	intact-crc:059F098F665A4A50|rigid:6fCUrC1AMiQgmmhxIhf3MSKBnoo	false	sufficient binding region:1-584|mutation:488-488	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q10567	uniprotkb:P84077	intact:EBI-1171303|uniprotkb:P78436|uniprotkb:C9JRD1|uniprotkb:Q20WL3|intact:EBI-11577132|uniprotkb:F8WDL0|uniprotkb:Q86X54|ensembl:ENSP00000319361|ensembl:ENSP00000350199|ensembl:ENSP00000384194|ensembl:ENSP00000400065	intact:EBI-447171|uniprotkb:P10947|uniprotkb:P32889|ensembl:ENSP00000272102|ensembl:ENSP00000440005|ensembl:ENSP00000442980	psi-mi:ap1b1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit beta-1(gene name synonym)|uniprotkb:Beta-adaptin 1(gene name synonym)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta large chain(gene name synonym)|uniprotkb:AP1B1(gene name)|psi-mi:AP1B1(display_short)|uniprotkb:ADTB1(gene name synonym)|uniprotkb:BAM22(gene name synonym)|uniprotkb:CLAPB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit beta-1(gene name synonym)	psi-mi:arf1_human(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6863559|wwpdb:4HMY|imex:IM-20905-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001118.3|refseq:NP_663782.2|refseq:NP_001159491.1|ensembl:ENSG00000100280(gene)|ensembl:ENST00000317368(transcript)|ensembl:ENST00000357586(transcript)|ensembl:ENST00000405198(transcript)|ensembl:ENST00000432560(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q10567|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|rcsb pdb:6CRI|dip:DIP-24207N	refseq:NP_001019397.1|refseq:NP_001019398.1|refseq:NP_001019399.1|refseq:NP_001649.1|dip:DIP-31597N|ensembl:ENSG00000143761(gene)|ensembl:ENST00000272102(transcript)|ensembl:ENST00000540651(transcript)|ensembl:ENST00000541182(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0043005"(neuron projection)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070142"(synaptic vesicle budding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097212"(lysosomal membrane organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:1903725"(regulation of phospholipid metabolic process)|go:"GO:1990386"(mitotic cleavage furrow ingression)|go:"GO:1990583"(phospholipase D activator activity)|interpro:IPR005225(Small GTP-binding protein)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84077|rcsb pdb:1HUR|rcsb pdb:1RE0|rcsb pdb:1U81|rcsb pdb:3O47|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|rcsb pdb:6FAE|rcsb pdb:7MGE|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-167590|reactome:R-HSA-199992|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-8950505	-	-	-	figure legend:Supp. Table 1|3d-r-factors:Rworking = 0.2 Rfree = 0.25|3d-resolution:7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/18	2016/02/11	rogid:D0i+5PXwzbBmOSyeCOSFKZx8fQk9606	rogid:zray9asm6VonxpuJpv0dRBspPt89606	intact-crc:059F098F665A4A50|rigid:6fCUrC1AMiQgmmhxIhf3MSKBnoo	false	sufficient binding region:1-584|mutation:488-488	sufficient binding region:17-181|mutation:71-71	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22892	uniprotkb:P84077	intact:EBI-1040262|ensembl:ENSMUSP00000034171	intact:EBI-447171|uniprotkb:P10947|uniprotkb:P32889|ensembl:ENSP00000272102|ensembl:ENSP00000440005|ensembl:ENSP00000442980	psi-mi:ap1g1_mouse(display_long)|uniprotkb:Ap1g1(gene name)|psi-mi:Ap1g1(display_short)|uniprotkb:Adtg(gene name synonym)|uniprotkb:Clapg1(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:arf1_human(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short)	psi-mi:"MI:0096"(pull down)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6864775|imex:IM-20905-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288140.1|ensembl:ENSMUSG00000031731(gene)|ensembl:ENSMUST00000034171(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005518"(collagen binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:P22892|rcsb pdb:1GYU|rcsb pdb:1GYV|rcsb pdb:1GYW|rcsb pdb:1W63|rcsb pdb:2A7B|rcsb pdb:3ZY7|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|go:"GO:0015630"(microtubule cytoskeleton)	refseq:NP_001019397.1|refseq:NP_001019398.1|refseq:NP_001019399.1|refseq:NP_001649.1|dip:DIP-31597N|ensembl:ENSG00000143761(gene)|ensembl:ENST00000272102(transcript)|ensembl:ENST00000540651(transcript)|ensembl:ENST00000541182(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0043005"(neuron projection)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070142"(synaptic vesicle budding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097212"(lysosomal membrane organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:1903725"(regulation of phospholipid metabolic process)|go:"GO:1990386"(mitotic cleavage furrow ingression)|go:"GO:1990583"(phospholipase D activator activity)|interpro:IPR005225(Small GTP-binding protein)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84077|rcsb pdb:1HUR|rcsb pdb:1RE0|rcsb pdb:1U81|rcsb pdb:3O47|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|rcsb pdb:6FAE|rcsb pdb:7MGE|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-167590|reactome:R-HSA-199992|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-8950505	-	-	-	figure legend:Fig. 3A, 3E, 3F, 5A, 5B, Supp. Fig. 2A|caution:Presence of the subunits demonstrated by Coomassie staining of the purified complex, however AP1S3 was not shown to be present. It has been included in this complex as it is present in the single polycistronic vector this complex was cloned into, and also because it was shown to be present in the crystal of this complex.|comment:Addition of a di-leucine-containing peptide from VAMP4  led to a 4-fold increase in the amount of Arf1 bound to the AP-1 core. Addition of peptide failed to rescue Arf1 binding to AP-1 complex containing mutated AP1B1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.0x10^-5(molar)	2013/06/18	2016/02/11	rogid:VeKvrfk0rSWIQfepmlhaOm293MI10090	rogid:zray9asm6VonxpuJpv0dRBspPt89606	intact-crc:FD763B04F8D8707B|rigid:6fCUrC1AMiQgmmhxIhf3MSKBnoo	false	sufficient binding region:1-595|glutathione s tranferase tag:c-c	sufficient binding region:17-181|his tag:n-n|mutation:71-71	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P22892	uniprotkb:Q96PC3	intact:EBI-1040262|ensembl:ENSMUSP00000034171	intact:EBI-3923129|uniprotkb:Q8WTY1|uniprotkb:Q96DD1|uniprotkb:B4DQZ1|ensembl:ENSP00000388738	psi-mi:ap1g1_mouse(display_long)|uniprotkb:Ap1g1(gene name)|psi-mi:Ap1g1(display_short)|uniprotkb:Adtg(gene name synonym)|uniprotkb:Clapg1(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:ap1s3_human(display_long)|uniprotkb:AP1S3(gene name)|psi-mi:AP1S3(display_short)|uniprotkb:Clathrin assembly protein complex 1 sigma-1C small chain(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin sigma-1C subunit(gene name synonym)|uniprotkb:Sigma 1C subunit of AP-1 clathrin(gene name synonym)|uniprotkb:Sigma-adaptin 1C(gene name synonym)|uniprotkb:Sigma1C-adaptin(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit sigma-1C(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit sigma-1C(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6864775|imex:IM-20905-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288140.1|ensembl:ENSMUSG00000031731(gene)|ensembl:ENSMUST00000034171(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005518"(collagen binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:P22892|rcsb pdb:1GYU|rcsb pdb:1GYV|rcsb pdb:1GYW|rcsb pdb:1W63|rcsb pdb:2A7B|rcsb pdb:3ZY7|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|go:"GO:0015630"(microtubule cytoskeleton)	refseq:NP_001034658.1|ensembl:ENSG00000152056(gene)|ensembl:ENST00000446015(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006605"(protein targeting)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR044733|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|go:"GO:0005829"(cytosol)|reactome:R-HSA-432722	-	-	-	figure legend:Fig. 3A, 3E, 3F, 5A, 5B, Supp. Fig. 2A|caution:Presence of the subunits demonstrated by Coomassie staining of the purified complex, however AP1S3 was not shown to be present. It has been included in this complex as it is present in the single polycistronic vector this complex was cloned into, and also because it was shown to be present in the crystal of this complex.|comment:Addition of a di-leucine-containing peptide from VAMP4  led to a 4-fold increase in the amount of Arf1 bound to the AP-1 core. Addition of peptide failed to rescue Arf1 binding to AP-1 complex containing mutated AP1B1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.0x10^-5(molar)	2013/06/18	2016/02/11	rogid:VeKvrfk0rSWIQfepmlhaOm293MI10090	rogid:4mRBQXekmJl9Ln+Bfq+jJbSkD409606	intact-crc:FD763B04F8D8707B|rigid:6fCUrC1AMiQgmmhxIhf3MSKBnoo	false	sufficient binding region:1-595|glutathione s tranferase tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P22892	uniprotkb:Q10567	intact:EBI-1040262|ensembl:ENSMUSP00000034171	intact:EBI-1171303|uniprotkb:P78436|uniprotkb:C9JRD1|uniprotkb:Q20WL3|intact:EBI-11577132|uniprotkb:F8WDL0|uniprotkb:Q86X54|ensembl:ENSP00000319361|ensembl:ENSP00000350199|ensembl:ENSP00000384194|ensembl:ENSP00000400065	psi-mi:ap1g1_mouse(display_long)|uniprotkb:Ap1g1(gene name)|psi-mi:Ap1g1(display_short)|uniprotkb:Adtg(gene name synonym)|uniprotkb:Clapg1(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:ap1b1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit beta-1(gene name synonym)|uniprotkb:Beta-adaptin 1(gene name synonym)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta large chain(gene name synonym)|uniprotkb:AP1B1(gene name)|psi-mi:AP1B1(display_short)|uniprotkb:ADTB1(gene name synonym)|uniprotkb:BAM22(gene name synonym)|uniprotkb:CLAPB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit beta-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6864775|imex:IM-20905-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288140.1|ensembl:ENSMUSG00000031731(gene)|ensembl:ENSMUST00000034171(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005518"(collagen binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:P22892|rcsb pdb:1GYU|rcsb pdb:1GYV|rcsb pdb:1GYW|rcsb pdb:1W63|rcsb pdb:2A7B|rcsb pdb:3ZY7|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|go:"GO:0015630"(microtubule cytoskeleton)	refseq:NP_001118.3|refseq:NP_663782.2|refseq:NP_001159491.1|ensembl:ENSG00000100280(gene)|ensembl:ENST00000317368(transcript)|ensembl:ENST00000357586(transcript)|ensembl:ENST00000405198(transcript)|ensembl:ENST00000432560(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q10567|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|rcsb pdb:6CRI|dip:DIP-24207N	-	-	-	figure legend:Fig. 3A, 3E, 3F, 5A, 5B, Supp. Fig. 2A|caution:Presence of the subunits demonstrated by Coomassie staining of the purified complex, however AP1S3 was not shown to be present. It has been included in this complex as it is present in the single polycistronic vector this complex was cloned into, and also because it was shown to be present in the crystal of this complex.|comment:Addition of a di-leucine-containing peptide from VAMP4  led to a 4-fold increase in the amount of Arf1 bound to the AP-1 core. Addition of peptide failed to rescue Arf1 binding to AP-1 complex containing mutated AP1B1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.0x10^-5(molar)	2013/06/18	2016/02/11	rogid:VeKvrfk0rSWIQfepmlhaOm293MI10090	rogid:D0i+5PXwzbBmOSyeCOSFKZx8fQk9606	intact-crc:FD763B04F8D8707B|rigid:6fCUrC1AMiQgmmhxIhf3MSKBnoo	false	sufficient binding region:1-595|glutathione s tranferase tag:c-c	sufficient binding region:1-584|mutation:488-488|his tag:n-n|mutation disrupting interaction strength:85-85,88-88	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P22892	uniprotkb:P35585	intact:EBI-1040262|ensembl:ENSMUSP00000034171	intact:EBI-1040251|ensembl:ENSMUSP00000003117	psi-mi:ap1g1_mouse(display_long)|uniprotkb:Ap1g1(gene name)|psi-mi:Ap1g1(display_short)|uniprotkb:Adtg(gene name synonym)|uniprotkb:Clapg1(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:ap1m1_mouse(display_long)|uniprotkb:Ap1m1(gene name)|psi-mi:Ap1m1(display_short)|uniprotkb:Cltnm(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin mu-1 subunit(gene name synonym)|uniprotkb:Mu-adaptin 1(gene name synonym)|uniprotkb:AP-mu chain family member mu1A(gene name synonym)|uniprotkb:Mu1A-adaptin(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP47(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP47(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit mu-1(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 mu-1 medium chain 1(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit mu-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6864775|imex:IM-20905-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288140.1|ensembl:ENSMUSG00000031731(gene)|ensembl:ENSMUST00000034171(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005518"(collagen binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:P22892|rcsb pdb:1GYU|rcsb pdb:1GYV|rcsb pdb:1GYW|rcsb pdb:1W63|rcsb pdb:2A7B|rcsb pdb:3ZY7|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|go:"GO:0015630"(microtubule cytoskeleton)	refseq:NP_031482.1|ensembl:ENSMUSG00000003033(gene)|ensembl:ENSMUST00000003117(transcript)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032438"(melanosome organization)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR028565|interpro:IPR036168|mint:P35585|rcsb pdb:1W63|rcsb pdb:4EMZ|rcsb pdb:4EN2|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-6798695|dip:DIP-35323N	-	-	-	figure legend:Fig. 3A, 3E, 3F, 5A, 5B, Supp. Fig. 2A|caution:Presence of the subunits demonstrated by Coomassie staining of the purified complex, however AP1S3 was not shown to be present. It has been included in this complex as it is present in the single polycistronic vector this complex was cloned into, and also because it was shown to be present in the crystal of this complex.|comment:Addition of a di-leucine-containing peptide from VAMP4  led to a 4-fold increase in the amount of Arf1 bound to the AP-1 core. Addition of peptide failed to rescue Arf1 binding to AP-1 complex containing mutated AP1B1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.0x10^-5(molar)	2013/06/18	2016/02/11	rogid:VeKvrfk0rSWIQfepmlhaOm293MI10090	rogid:jng3stxfxbi8Emuhlquac0/JC0Q10090	intact-crc:FD763B04F8D8707B|rigid:6fCUrC1AMiQgmmhxIhf3MSKBnoo	false	sufficient binding region:1-595|glutathione s tranferase tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P22892	uniprotkb:P35585	intact:EBI-1040262|ensembl:ENSMUSP00000034171	intact:EBI-1040251|ensembl:ENSMUSP00000003117	psi-mi:ap1g1_mouse(display_long)|uniprotkb:Ap1g1(gene name)|psi-mi:Ap1g1(display_short)|uniprotkb:Adtg(gene name synonym)|uniprotkb:Clapg1(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:ap1m1_mouse(display_long)|uniprotkb:Ap1m1(gene name)|psi-mi:Ap1m1(display_short)|uniprotkb:Cltnm(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin mu-1 subunit(gene name synonym)|uniprotkb:Mu-adaptin 1(gene name synonym)|uniprotkb:AP-mu chain family member mu1A(gene name synonym)|uniprotkb:Mu1A-adaptin(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP47(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP47(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit mu-1(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 mu-1 medium chain 1(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit mu-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6864698|imex:IM-20905-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288140.1|ensembl:ENSMUSG00000031731(gene)|ensembl:ENSMUST00000034171(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005518"(collagen binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:P22892|rcsb pdb:1GYU|rcsb pdb:1GYV|rcsb pdb:1GYW|rcsb pdb:1W63|rcsb pdb:2A7B|rcsb pdb:3ZY7|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|go:"GO:0015630"(microtubule cytoskeleton)	refseq:NP_031482.1|ensembl:ENSMUSG00000003033(gene)|ensembl:ENSMUST00000003117(transcript)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032438"(melanosome organization)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR028565|interpro:IPR036168|mint:P35585|rcsb pdb:1W63|rcsb pdb:4EMZ|rcsb pdb:4EN2|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-6798695|dip:DIP-35323N	-	-	-	figure legend:Fig. 3A, 3C, 3E, 3F, 5C, Supp. Fig. 2A|caution:Presence of the subunits demonstrated by Coomassie staining of the purified complex, however AP1S3 was not shown to be present. It has been included in this complex as it is present in the single polycistronic vector this complex was cloned into, and also because it was shown to be present in the crystal of this complex.|comment:Addition of a di-leucine-containing peptide from VAMP4 led to a 4-fold increase in the amount of Arf1 bound to the AP-1 core. Arf1-W172D tightly bound to GST-AP1-A core independent of the VAMP4 peptide.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.0x10^-5(molar)	2013/06/18	2016/02/11	rogid:VeKvrfk0rSWIQfepmlhaOm293MI10090	rogid:jng3stxfxbi8Emuhlquac0/JC0Q10090	intact-crc:8BB037F2F091CDD1|rigid:6fCUrC1AMiQgmmhxIhf3MSKBnoo	false	sufficient binding region:1-595|glutathione s tranferase tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P22892	uniprotkb:Q10567	intact:EBI-1040262|ensembl:ENSMUSP00000034171	intact:EBI-1171303|uniprotkb:P78436|uniprotkb:C9JRD1|uniprotkb:Q20WL3|intact:EBI-11577132|uniprotkb:F8WDL0|uniprotkb:Q86X54|ensembl:ENSP00000319361|ensembl:ENSP00000350199|ensembl:ENSP00000384194|ensembl:ENSP00000400065	psi-mi:ap1g1_mouse(display_long)|uniprotkb:Ap1g1(gene name)|psi-mi:Ap1g1(display_short)|uniprotkb:Adtg(gene name synonym)|uniprotkb:Clapg1(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:ap1b1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit beta-1(gene name synonym)|uniprotkb:Beta-adaptin 1(gene name synonym)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta large chain(gene name synonym)|uniprotkb:AP1B1(gene name)|psi-mi:AP1B1(display_short)|uniprotkb:ADTB1(gene name synonym)|uniprotkb:BAM22(gene name synonym)|uniprotkb:CLAPB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit beta-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6864698|imex:IM-20905-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288140.1|ensembl:ENSMUSG00000031731(gene)|ensembl:ENSMUST00000034171(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005518"(collagen binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:P22892|rcsb pdb:1GYU|rcsb pdb:1GYV|rcsb pdb:1GYW|rcsb pdb:1W63|rcsb pdb:2A7B|rcsb pdb:3ZY7|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|go:"GO:0015630"(microtubule cytoskeleton)	refseq:NP_001118.3|refseq:NP_663782.2|refseq:NP_001159491.1|ensembl:ENSG00000100280(gene)|ensembl:ENST00000317368(transcript)|ensembl:ENST00000357586(transcript)|ensembl:ENST00000405198(transcript)|ensembl:ENST00000432560(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q10567|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|rcsb pdb:6CRI|dip:DIP-24207N	-	-	-	figure legend:Fig. 3A, 3C, 3E, 3F, 5C, Supp. Fig. 2A|caution:Presence of the subunits demonstrated by Coomassie staining of the purified complex, however AP1S3 was not shown to be present. It has been included in this complex as it is present in the single polycistronic vector this complex was cloned into, and also because it was shown to be present in the crystal of this complex.|comment:Addition of a di-leucine-containing peptide from VAMP4 led to a 4-fold increase in the amount of Arf1 bound to the AP-1 core. Arf1-W172D tightly bound to GST-AP1-A core independent of the VAMP4 peptide.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.0x10^-5(molar)	2013/06/18	2016/02/11	rogid:VeKvrfk0rSWIQfepmlhaOm293MI10090	rogid:D0i+5PXwzbBmOSyeCOSFKZx8fQk9606	intact-crc:8BB037F2F091CDD1|rigid:6fCUrC1AMiQgmmhxIhf3MSKBnoo	false	sufficient binding region:1-595|glutathione s tranferase tag:c-c	sufficient binding region:1-584|his tag:n-n|mutation:488-488	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P22892	uniprotkb:Q96PC3	intact:EBI-1040262|ensembl:ENSMUSP00000034171	intact:EBI-3923129|uniprotkb:Q8WTY1|uniprotkb:Q96DD1|uniprotkb:B4DQZ1|ensembl:ENSP00000388738	psi-mi:ap1g1_mouse(display_long)|uniprotkb:Ap1g1(gene name)|psi-mi:Ap1g1(display_short)|uniprotkb:Adtg(gene name synonym)|uniprotkb:Clapg1(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:ap1s3_human(display_long)|uniprotkb:AP1S3(gene name)|psi-mi:AP1S3(display_short)|uniprotkb:Clathrin assembly protein complex 1 sigma-1C small chain(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin sigma-1C subunit(gene name synonym)|uniprotkb:Sigma 1C subunit of AP-1 clathrin(gene name synonym)|uniprotkb:Sigma-adaptin 1C(gene name synonym)|uniprotkb:Sigma1C-adaptin(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit sigma-1C(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit sigma-1C(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6864698|imex:IM-20905-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288140.1|ensembl:ENSMUSG00000031731(gene)|ensembl:ENSMUST00000034171(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005518"(collagen binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:P22892|rcsb pdb:1GYU|rcsb pdb:1GYV|rcsb pdb:1GYW|rcsb pdb:1W63|rcsb pdb:2A7B|rcsb pdb:3ZY7|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|go:"GO:0015630"(microtubule cytoskeleton)	refseq:NP_001034658.1|ensembl:ENSG00000152056(gene)|ensembl:ENST00000446015(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006605"(protein targeting)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR044733|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|go:"GO:0005829"(cytosol)|reactome:R-HSA-432722	-	-	-	figure legend:Fig. 3A, 3C, 3E, 3F, 5C, Supp. Fig. 2A|caution:Presence of the subunits demonstrated by Coomassie staining of the purified complex, however AP1S3 was not shown to be present. It has been included in this complex as it is present in the single polycistronic vector this complex was cloned into, and also because it was shown to be present in the crystal of this complex.|comment:Addition of a di-leucine-containing peptide from VAMP4 led to a 4-fold increase in the amount of Arf1 bound to the AP-1 core. Arf1-W172D tightly bound to GST-AP1-A core independent of the VAMP4 peptide.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.0x10^-5(molar)	2013/06/18	2016/02/11	rogid:VeKvrfk0rSWIQfepmlhaOm293MI10090	rogid:4mRBQXekmJl9Ln+Bfq+jJbSkD409606	intact-crc:8BB037F2F091CDD1|rigid:6fCUrC1AMiQgmmhxIhf3MSKBnoo	false	sufficient binding region:1-595|glutathione s tranferase tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P22892	uniprotkb:P84077	intact:EBI-1040262|ensembl:ENSMUSP00000034171	intact:EBI-447171|uniprotkb:P10947|uniprotkb:P32889|ensembl:ENSP00000272102|ensembl:ENSP00000440005|ensembl:ENSP00000442980	psi-mi:ap1g1_mouse(display_long)|uniprotkb:Ap1g1(gene name)|psi-mi:Ap1g1(display_short)|uniprotkb:Adtg(gene name synonym)|uniprotkb:Clapg1(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:arf1_human(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short)	psi-mi:"MI:0096"(pull down)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6864698|imex:IM-20905-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288140.1|ensembl:ENSMUSG00000031731(gene)|ensembl:ENSMUST00000034171(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005518"(collagen binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:P22892|rcsb pdb:1GYU|rcsb pdb:1GYV|rcsb pdb:1GYW|rcsb pdb:1W63|rcsb pdb:2A7B|rcsb pdb:3ZY7|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|go:"GO:0015630"(microtubule cytoskeleton)	refseq:NP_001019397.1|refseq:NP_001019398.1|refseq:NP_001019399.1|refseq:NP_001649.1|dip:DIP-31597N|ensembl:ENSG00000143761(gene)|ensembl:ENST00000272102(transcript)|ensembl:ENST00000540651(transcript)|ensembl:ENST00000541182(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0043005"(neuron projection)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070142"(synaptic vesicle budding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097212"(lysosomal membrane organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:1903725"(regulation of phospholipid metabolic process)|go:"GO:1990386"(mitotic cleavage furrow ingression)|go:"GO:1990583"(phospholipase D activator activity)|interpro:IPR005225(Small GTP-binding protein)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84077|rcsb pdb:1HUR|rcsb pdb:1RE0|rcsb pdb:1U81|rcsb pdb:3O47|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|rcsb pdb:6FAE|rcsb pdb:7MGE|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-167590|reactome:R-HSA-199992|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-8950505	-	-	-	figure legend:Fig. 3A, 3C, 3E, 3F, 5C, Supp. Fig. 2A|caution:Presence of the subunits demonstrated by Coomassie staining of the purified complex, however AP1S3 was not shown to be present. It has been included in this complex as it is present in the single polycistronic vector this complex was cloned into, and also because it was shown to be present in the crystal of this complex.|comment:Addition of a di-leucine-containing peptide from VAMP4 led to a 4-fold increase in the amount of Arf1 bound to the AP-1 core. Arf1-W172D tightly bound to GST-AP1-A core independent of the VAMP4 peptide.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.0x10^-5(molar)	2013/06/18	2016/02/11	rogid:VeKvrfk0rSWIQfepmlhaOm293MI10090	rogid:zray9asm6VonxpuJpv0dRBspPt89606	intact-crc:8BB037F2F091CDD1|rigid:6fCUrC1AMiQgmmhxIhf3MSKBnoo	false	sufficient binding region:1-595|glutathione s tranferase tag:c-c	sufficient binding region:17-181|his tag:n-n|mutation increasing interaction strength:172-172|mutation disrupting interaction strength:49-49|mutation decreasing interaction strength:53-53|mutation increasing interaction strength:136-137|mutation disrupting interaction strength:77-77,80-80|mutation decreasing interaction strength:73-73|mutation:71-71	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P22892	uniprotkb:Q96PC3	intact:EBI-1040262|ensembl:ENSMUSP00000034171	intact:EBI-3923129|uniprotkb:Q8WTY1|uniprotkb:Q96DD1|uniprotkb:B4DQZ1|ensembl:ENSP00000388738	psi-mi:ap1g1_mouse(display_long)|uniprotkb:Ap1g1(gene name)|psi-mi:Ap1g1(display_short)|uniprotkb:Adtg(gene name synonym)|uniprotkb:Clapg1(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:ap1s3_human(display_long)|uniprotkb:AP1S3(gene name)|psi-mi:AP1S3(display_short)|uniprotkb:Clathrin assembly protein complex 1 sigma-1C small chain(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin sigma-1C subunit(gene name synonym)|uniprotkb:Sigma 1C subunit of AP-1 clathrin(gene name synonym)|uniprotkb:Sigma-adaptin 1C(gene name synonym)|uniprotkb:Sigma1C-adaptin(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit sigma-1C(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit sigma-1C(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6868092|imex:IM-20905-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288140.1|ensembl:ENSMUSG00000031731(gene)|ensembl:ENSMUST00000034171(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005518"(collagen binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:P22892|rcsb pdb:1GYU|rcsb pdb:1GYV|rcsb pdb:1GYW|rcsb pdb:1W63|rcsb pdb:2A7B|rcsb pdb:3ZY7|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|go:"GO:0015630"(microtubule cytoskeleton)	refseq:NP_001034658.1|ensembl:ENSG00000152056(gene)|ensembl:ENST00000446015(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006605"(protein targeting)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR044733|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|go:"GO:0005829"(cytosol)|reactome:R-HSA-432722	-	-	-	figure legend:Fig. 3A, 3B, 5A, 5B, Supp. Fig. 2|caution:Presence of the subunits demonstrated by Coomassie staining of the purified complex, however AP1S3 was not shown to be present. It has been included in this complex as it is present in the single polycistronic vector this complex was cloned into, and also because it was shown to be present in the crystal of this complex.|comment:Addition of a di-leucine-containing peptide from VAMP4  led to a 4-fold increase in the amount of Arf1 bound to the AP-1 core. The  form of the AP-1 complex containing mutated AP1G1 binds weakly to Arf1 in the absence of peptide, this is enhanced  4-fold when peptide is present.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/18	2016/02/11	rogid:VeKvrfk0rSWIQfepmlhaOm293MI10090	rogid:4mRBQXekmJl9Ln+Bfq+jJbSkD409606	intact-crc:081EB321E670AC80|rigid:6fCUrC1AMiQgmmhxIhf3MSKBnoo	false	sufficient binding region:1-595|glutathione s tranferase tag:c-c|mutation disrupting interaction strength:68-68,71-71,102-102|mutation decreasing interaction strength:102-102|mutation decreasing interaction strength:68-68,71-71	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P22892	uniprotkb:Q10567	intact:EBI-1040262|ensembl:ENSMUSP00000034171	intact:EBI-1171303|uniprotkb:P78436|uniprotkb:C9JRD1|uniprotkb:Q20WL3|intact:EBI-11577132|uniprotkb:F8WDL0|uniprotkb:Q86X54|ensembl:ENSP00000319361|ensembl:ENSP00000350199|ensembl:ENSP00000384194|ensembl:ENSP00000400065	psi-mi:ap1g1_mouse(display_long)|uniprotkb:Ap1g1(gene name)|psi-mi:Ap1g1(display_short)|uniprotkb:Adtg(gene name synonym)|uniprotkb:Clapg1(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:ap1b1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit beta-1(gene name synonym)|uniprotkb:Beta-adaptin 1(gene name synonym)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta large chain(gene name synonym)|uniprotkb:AP1B1(gene name)|psi-mi:AP1B1(display_short)|uniprotkb:ADTB1(gene name synonym)|uniprotkb:BAM22(gene name synonym)|uniprotkb:CLAPB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit beta-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6868092|imex:IM-20905-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288140.1|ensembl:ENSMUSG00000031731(gene)|ensembl:ENSMUST00000034171(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005518"(collagen binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:P22892|rcsb pdb:1GYU|rcsb pdb:1GYV|rcsb pdb:1GYW|rcsb pdb:1W63|rcsb pdb:2A7B|rcsb pdb:3ZY7|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|go:"GO:0015630"(microtubule cytoskeleton)	refseq:NP_001118.3|refseq:NP_663782.2|refseq:NP_001159491.1|ensembl:ENSG00000100280(gene)|ensembl:ENST00000317368(transcript)|ensembl:ENST00000357586(transcript)|ensembl:ENST00000405198(transcript)|ensembl:ENST00000432560(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q10567|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|rcsb pdb:6CRI|dip:DIP-24207N	-	-	-	figure legend:Fig. 3A, 3B, 5A, 5B, Supp. Fig. 2|caution:Presence of the subunits demonstrated by Coomassie staining of the purified complex, however AP1S3 was not shown to be present. It has been included in this complex as it is present in the single polycistronic vector this complex was cloned into, and also because it was shown to be present in the crystal of this complex.|comment:Addition of a di-leucine-containing peptide from VAMP4  led to a 4-fold increase in the amount of Arf1 bound to the AP-1 core. The  form of the AP-1 complex containing mutated AP1G1 binds weakly to Arf1 in the absence of peptide, this is enhanced  4-fold when peptide is present.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/18	2016/02/11	rogid:VeKvrfk0rSWIQfepmlhaOm293MI10090	rogid:D0i+5PXwzbBmOSyeCOSFKZx8fQk9606	intact-crc:081EB321E670AC80|rigid:6fCUrC1AMiQgmmhxIhf3MSKBnoo	false	sufficient binding region:1-595|glutathione s tranferase tag:c-c|mutation disrupting interaction strength:68-68,71-71,102-102|mutation decreasing interaction strength:102-102|mutation decreasing interaction strength:68-68,71-71	sufficient binding region:1-584|mutation:488-488|his tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P22892	uniprotkb:P84077	intact:EBI-1040262|ensembl:ENSMUSP00000034171	intact:EBI-447171|uniprotkb:P10947|uniprotkb:P32889|ensembl:ENSP00000272102|ensembl:ENSP00000440005|ensembl:ENSP00000442980	psi-mi:ap1g1_mouse(display_long)|uniprotkb:Ap1g1(gene name)|psi-mi:Ap1g1(display_short)|uniprotkb:Adtg(gene name synonym)|uniprotkb:Clapg1(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:arf1_human(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short)	psi-mi:"MI:0096"(pull down)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6868092|imex:IM-20905-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288140.1|ensembl:ENSMUSG00000031731(gene)|ensembl:ENSMUST00000034171(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005518"(collagen binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:P22892|rcsb pdb:1GYU|rcsb pdb:1GYV|rcsb pdb:1GYW|rcsb pdb:1W63|rcsb pdb:2A7B|rcsb pdb:3ZY7|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|go:"GO:0015630"(microtubule cytoskeleton)	refseq:NP_001019397.1|refseq:NP_001019398.1|refseq:NP_001019399.1|refseq:NP_001649.1|dip:DIP-31597N|ensembl:ENSG00000143761(gene)|ensembl:ENST00000272102(transcript)|ensembl:ENST00000540651(transcript)|ensembl:ENST00000541182(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0043005"(neuron projection)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070142"(synaptic vesicle budding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097212"(lysosomal membrane organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:1903725"(regulation of phospholipid metabolic process)|go:"GO:1990386"(mitotic cleavage furrow ingression)|go:"GO:1990583"(phospholipase D activator activity)|interpro:IPR005225(Small GTP-binding protein)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84077|rcsb pdb:1HUR|rcsb pdb:1RE0|rcsb pdb:1U81|rcsb pdb:3O47|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|rcsb pdb:6FAE|rcsb pdb:7MGE|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-167590|reactome:R-HSA-199992|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-8950505	-	-	-	figure legend:Fig. 3A, 3B, 5A, 5B, Supp. Fig. 2|caution:Presence of the subunits demonstrated by Coomassie staining of the purified complex, however AP1S3 was not shown to be present. It has been included in this complex as it is present in the single polycistronic vector this complex was cloned into, and also because it was shown to be present in the crystal of this complex.|comment:Addition of a di-leucine-containing peptide from VAMP4  led to a 4-fold increase in the amount of Arf1 bound to the AP-1 core. The  form of the AP-1 complex containing mutated AP1G1 binds weakly to Arf1 in the absence of peptide, this is enhanced  4-fold when peptide is present.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/18	2016/02/11	rogid:VeKvrfk0rSWIQfepmlhaOm293MI10090	rogid:zray9asm6VonxpuJpv0dRBspPt89606	intact-crc:081EB321E670AC80|rigid:6fCUrC1AMiQgmmhxIhf3MSKBnoo	false	sufficient binding region:1-595|glutathione s tranferase tag:c-c|mutation disrupting interaction strength:68-68,71-71,102-102|mutation decreasing interaction strength:102-102|mutation decreasing interaction strength:68-68,71-71	his tag:n-n|sufficient binding region:17-181|mutation:71-71	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P22892	uniprotkb:P35585	intact:EBI-1040262|ensembl:ENSMUSP00000034171	intact:EBI-1040251|ensembl:ENSMUSP00000003117	psi-mi:ap1g1_mouse(display_long)|uniprotkb:Ap1g1(gene name)|psi-mi:Ap1g1(display_short)|uniprotkb:Adtg(gene name synonym)|uniprotkb:Clapg1(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:ap1m1_mouse(display_long)|uniprotkb:Ap1m1(gene name)|psi-mi:Ap1m1(display_short)|uniprotkb:Cltnm(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin mu-1 subunit(gene name synonym)|uniprotkb:Mu-adaptin 1(gene name synonym)|uniprotkb:AP-mu chain family member mu1A(gene name synonym)|uniprotkb:Mu1A-adaptin(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP47(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP47(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit mu-1(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 mu-1 medium chain 1(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit mu-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6868092|imex:IM-20905-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288140.1|ensembl:ENSMUSG00000031731(gene)|ensembl:ENSMUST00000034171(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005518"(collagen binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:P22892|rcsb pdb:1GYU|rcsb pdb:1GYV|rcsb pdb:1GYW|rcsb pdb:1W63|rcsb pdb:2A7B|rcsb pdb:3ZY7|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|go:"GO:0015630"(microtubule cytoskeleton)	refseq:NP_031482.1|ensembl:ENSMUSG00000003033(gene)|ensembl:ENSMUST00000003117(transcript)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032438"(melanosome organization)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR028565|interpro:IPR036168|mint:P35585|rcsb pdb:1W63|rcsb pdb:4EMZ|rcsb pdb:4EN2|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-6798695|dip:DIP-35323N	-	-	-	figure legend:Fig. 3A, 3B, 5A, 5B, Supp. Fig. 2|caution:Presence of the subunits demonstrated by Coomassie staining of the purified complex, however AP1S3 was not shown to be present. It has been included in this complex as it is present in the single polycistronic vector this complex was cloned into, and also because it was shown to be present in the crystal of this complex.|comment:Addition of a di-leucine-containing peptide from VAMP4  led to a 4-fold increase in the amount of Arf1 bound to the AP-1 core. The  form of the AP-1 complex containing mutated AP1G1 binds weakly to Arf1 in the absence of peptide, this is enhanced  4-fold when peptide is present.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/18	2016/02/11	rogid:VeKvrfk0rSWIQfepmlhaOm293MI10090	rogid:jng3stxfxbi8Emuhlquac0/JC0Q10090	intact-crc:081EB321E670AC80|rigid:6fCUrC1AMiQgmmhxIhf3MSKBnoo	false	sufficient binding region:1-595|glutathione s tranferase tag:c-c|mutation disrupting interaction strength:68-68,71-71,102-102|mutation decreasing interaction strength:102-102|mutation decreasing interaction strength:68-68,71-71	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q10567	uniprotkb:P22892	intact:EBI-1171303|uniprotkb:P78436|uniprotkb:C9JRD1|uniprotkb:Q20WL3|intact:EBI-11577132|uniprotkb:F8WDL0|uniprotkb:Q86X54|ensembl:ENSP00000319361|ensembl:ENSP00000350199|ensembl:ENSP00000384194|ensembl:ENSP00000400065	intact:EBI-1040262|ensembl:ENSMUSP00000034171	psi-mi:ap1b1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit beta-1(gene name synonym)|uniprotkb:Beta-adaptin 1(gene name synonym)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta large chain(gene name synonym)|uniprotkb:AP1B1(gene name)|psi-mi:AP1B1(display_short)|uniprotkb:ADTB1(gene name synonym)|uniprotkb:BAM22(gene name synonym)|uniprotkb:CLAPB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit beta-1(gene name synonym)	psi-mi:ap1g1_mouse(display_long)|uniprotkb:Ap1g1(gene name)|psi-mi:Ap1g1(display_short)|uniprotkb:Adtg(gene name synonym)|uniprotkb:Clapg1(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6867876|imex:IM-20905-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001118.3|refseq:NP_663782.2|refseq:NP_001159491.1|ensembl:ENSG00000100280(gene)|ensembl:ENST00000317368(transcript)|ensembl:ENST00000357586(transcript)|ensembl:ENST00000405198(transcript)|ensembl:ENST00000432560(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q10567|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|rcsb pdb:6CRI|dip:DIP-24207N	refseq:NP_001288140.1|ensembl:ENSMUSG00000031731(gene)|ensembl:ENSMUST00000034171(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005518"(collagen binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:P22892|rcsb pdb:1GYU|rcsb pdb:1GYV|rcsb pdb:1GYW|rcsb pdb:1W63|rcsb pdb:2A7B|rcsb pdb:3ZY7|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|go:"GO:0015630"(microtubule cytoskeleton)	-	-	-	figure legend:Supp. Fig. 3|comment:Melting temperatures Tm of 56–58C were measured  and no sign of melting was observed for any of the constructs at the temperatures T = 25C or T = 37C at which the in vitro and biological experiments were carried out.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/18	2016/02/11	rogid:D0i+5PXwzbBmOSyeCOSFKZx8fQk9606	rogid:VeKvrfk0rSWIQfepmlhaOm293MI10090	intact-crc:83BF7BE2AF938F67|rigid:z9vXhGUUKaxwFo6NPAp2najZ+7c	false	mutation:488-488|sufficient binding region:1-584	sufficient binding region:1-595	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q10567	uniprotkb:P35585	intact:EBI-1171303|uniprotkb:P78436|uniprotkb:C9JRD1|uniprotkb:Q20WL3|intact:EBI-11577132|uniprotkb:F8WDL0|uniprotkb:Q86X54|ensembl:ENSP00000319361|ensembl:ENSP00000350199|ensembl:ENSP00000384194|ensembl:ENSP00000400065	intact:EBI-1040251|ensembl:ENSMUSP00000003117	psi-mi:ap1b1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit beta-1(gene name synonym)|uniprotkb:Beta-adaptin 1(gene name synonym)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta large chain(gene name synonym)|uniprotkb:AP1B1(gene name)|psi-mi:AP1B1(display_short)|uniprotkb:ADTB1(gene name synonym)|uniprotkb:BAM22(gene name synonym)|uniprotkb:CLAPB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit beta-1(gene name synonym)	psi-mi:ap1m1_mouse(display_long)|uniprotkb:Ap1m1(gene name)|psi-mi:Ap1m1(display_short)|uniprotkb:Cltnm(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin mu-1 subunit(gene name synonym)|uniprotkb:Mu-adaptin 1(gene name synonym)|uniprotkb:AP-mu chain family member mu1A(gene name synonym)|uniprotkb:Mu1A-adaptin(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP47(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP47(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit mu-1(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 mu-1 medium chain 1(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit mu-1(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6867876|imex:IM-20905-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001118.3|refseq:NP_663782.2|refseq:NP_001159491.1|ensembl:ENSG00000100280(gene)|ensembl:ENST00000317368(transcript)|ensembl:ENST00000357586(transcript)|ensembl:ENST00000405198(transcript)|ensembl:ENST00000432560(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q10567|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|rcsb pdb:6CRI|dip:DIP-24207N	refseq:NP_031482.1|ensembl:ENSMUSG00000003033(gene)|ensembl:ENSMUST00000003117(transcript)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032438"(melanosome organization)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR028565|interpro:IPR036168|mint:P35585|rcsb pdb:1W63|rcsb pdb:4EMZ|rcsb pdb:4EN2|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-6798695|dip:DIP-35323N	-	-	-	figure legend:Supp. Fig. 3|comment:Melting temperatures Tm of 56–58C were measured  and no sign of melting was observed for any of the constructs at the temperatures T = 25C or T = 37C at which the in vitro and biological experiments were carried out.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/18	2016/02/11	rogid:D0i+5PXwzbBmOSyeCOSFKZx8fQk9606	rogid:jng3stxfxbi8Emuhlquac0/JC0Q10090	intact-crc:83BF7BE2AF938F67|rigid:z9vXhGUUKaxwFo6NPAp2najZ+7c	false	mutation:488-488|sufficient binding region:1-584	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q10567	uniprotkb:Q96PC3	intact:EBI-1171303|uniprotkb:P78436|uniprotkb:C9JRD1|uniprotkb:Q20WL3|intact:EBI-11577132|uniprotkb:F8WDL0|uniprotkb:Q86X54|ensembl:ENSP00000319361|ensembl:ENSP00000350199|ensembl:ENSP00000384194|ensembl:ENSP00000400065	intact:EBI-3923129|uniprotkb:Q8WTY1|uniprotkb:Q96DD1|uniprotkb:B4DQZ1|ensembl:ENSP00000388738	psi-mi:ap1b1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit beta-1(gene name synonym)|uniprotkb:Beta-adaptin 1(gene name synonym)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta large chain(gene name synonym)|uniprotkb:AP1B1(gene name)|psi-mi:AP1B1(display_short)|uniprotkb:ADTB1(gene name synonym)|uniprotkb:BAM22(gene name synonym)|uniprotkb:CLAPB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit beta-1(gene name synonym)	psi-mi:ap1s3_human(display_long)|uniprotkb:AP1S3(gene name)|psi-mi:AP1S3(display_short)|uniprotkb:Clathrin assembly protein complex 1 sigma-1C small chain(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin sigma-1C subunit(gene name synonym)|uniprotkb:Sigma 1C subunit of AP-1 clathrin(gene name synonym)|uniprotkb:Sigma-adaptin 1C(gene name synonym)|uniprotkb:Sigma1C-adaptin(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit sigma-1C(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit sigma-1C(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6867876|imex:IM-20905-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001118.3|refseq:NP_663782.2|refseq:NP_001159491.1|ensembl:ENSG00000100280(gene)|ensembl:ENST00000317368(transcript)|ensembl:ENST00000357586(transcript)|ensembl:ENST00000405198(transcript)|ensembl:ENST00000432560(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q10567|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|rcsb pdb:6CRI|dip:DIP-24207N	refseq:NP_001034658.1|ensembl:ENSG00000152056(gene)|ensembl:ENST00000446015(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006605"(protein targeting)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR044733|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|go:"GO:0005829"(cytosol)|reactome:R-HSA-432722	-	-	-	figure legend:Supp. Fig. 3|comment:Melting temperatures Tm of 56–58C were measured  and no sign of melting was observed for any of the constructs at the temperatures T = 25C or T = 37C at which the in vitro and biological experiments were carried out.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/18	2016/02/11	rogid:D0i+5PXwzbBmOSyeCOSFKZx8fQk9606	rogid:4mRBQXekmJl9Ln+Bfq+jJbSkD409606	intact-crc:83BF7BE2AF938F67|rigid:z9vXhGUUKaxwFo6NPAp2najZ+7c	false	mutation:488-488|sufficient binding region:1-584	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q10567	uniprotkb:P35585	intact:EBI-1171303|uniprotkb:P78436|uniprotkb:C9JRD1|uniprotkb:Q20WL3|intact:EBI-11577132|uniprotkb:F8WDL0|uniprotkb:Q86X54|ensembl:ENSP00000319361|ensembl:ENSP00000350199|ensembl:ENSP00000384194|ensembl:ENSP00000400065	intact:EBI-1040251|ensembl:ENSMUSP00000003117	psi-mi:ap1b1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit beta-1(gene name synonym)|uniprotkb:Beta-adaptin 1(gene name synonym)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta large chain(gene name synonym)|uniprotkb:AP1B1(gene name)|psi-mi:AP1B1(display_short)|uniprotkb:ADTB1(gene name synonym)|uniprotkb:BAM22(gene name synonym)|uniprotkb:CLAPB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit beta-1(gene name synonym)	psi-mi:ap1m1_mouse(display_long)|uniprotkb:Ap1m1(gene name)|psi-mi:Ap1m1(display_short)|uniprotkb:Cltnm(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin mu-1 subunit(gene name synonym)|uniprotkb:Mu-adaptin 1(gene name synonym)|uniprotkb:AP-mu chain family member mu1A(gene name synonym)|uniprotkb:Mu1A-adaptin(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP47(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP47(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit mu-1(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 mu-1 medium chain 1(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit mu-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6867952|imex:IM-20905-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001118.3|refseq:NP_663782.2|refseq:NP_001159491.1|ensembl:ENSG00000100280(gene)|ensembl:ENST00000317368(transcript)|ensembl:ENST00000357586(transcript)|ensembl:ENST00000405198(transcript)|ensembl:ENST00000432560(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q10567|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|rcsb pdb:6CRI|dip:DIP-24207N	refseq:NP_031482.1|ensembl:ENSMUSG00000003033(gene)|ensembl:ENSMUST00000003117(transcript)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032438"(melanosome organization)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR028565|interpro:IPR036168|mint:P35585|rcsb pdb:1W63|rcsb pdb:4EMZ|rcsb pdb:4EN2|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-6798695|dip:DIP-35323N	-	-	-	figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2013/06/18	2016/02/11	rogid:D0i+5PXwzbBmOSyeCOSFKZx8fQk9606	rogid:jng3stxfxbi8Emuhlquac0/JC0Q10090	intact-crc:9954C05E370325F2|rigid:spSN5KC6TrP69DUJBj44wZqVb4w	false	enhanced green fluorescent protein tag:?-?|sufficient binding region:1-584	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35585	uniprotkb:P22892	intact:EBI-1040251|ensembl:ENSMUSP00000003117	intact:EBI-1040262|ensembl:ENSMUSP00000034171	psi-mi:ap1m1_mouse(display_long)|uniprotkb:Ap1m1(gene name)|psi-mi:Ap1m1(display_short)|uniprotkb:Cltnm(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin mu-1 subunit(gene name synonym)|uniprotkb:Mu-adaptin 1(gene name synonym)|uniprotkb:AP-mu chain family member mu1A(gene name synonym)|uniprotkb:Mu1A-adaptin(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP47(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP47(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit mu-1(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 mu-1 medium chain 1(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit mu-1(gene name synonym)	psi-mi:ap1g1_mouse(display_long)|uniprotkb:Ap1g1(gene name)|psi-mi:Ap1g1(display_short)|uniprotkb:Adtg(gene name synonym)|uniprotkb:Clapg1(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6867969|imex:IM-20905-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031482.1|ensembl:ENSMUSG00000003033(gene)|ensembl:ENSMUST00000003117(transcript)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032438"(melanosome organization)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR028565|interpro:IPR036168|mint:P35585|rcsb pdb:1W63|rcsb pdb:4EMZ|rcsb pdb:4EN2|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-6798695|dip:DIP-35323N	refseq:NP_001288140.1|ensembl:ENSMUSG00000031731(gene)|ensembl:ENSMUST00000034171(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005518"(collagen binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:P22892|rcsb pdb:1GYU|rcsb pdb:1GYV|rcsb pdb:1GYW|rcsb pdb:1W63|rcsb pdb:2A7B|rcsb pdb:3ZY7|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|go:"GO:0015630"(microtubule cytoskeleton)	-	-	-	figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2013/06/18	2014/10/16	rogid:jng3stxfxbi8Emuhlquac0/JC0Q10090	rogid:VeKvrfk0rSWIQfepmlhaOm293MI10090	intact-crc:71E5A4577EE62034|rigid:DtGpsxbPUG/on0KAbXLq4gLTXQ0	false	ha tag:?-?	sufficient binding region:1-595|enhanced green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P22892	uniprotkb:P35585	intact:EBI-1040262|ensembl:ENSMUSP00000034171	intact:EBI-1040251|ensembl:ENSMUSP00000003117	psi-mi:ap1g1_mouse(display_long)|uniprotkb:Ap1g1(gene name)|psi-mi:Ap1g1(display_short)|uniprotkb:Adtg(gene name synonym)|uniprotkb:Clapg1(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:ap1m1_mouse(display_long)|uniprotkb:Ap1m1(gene name)|psi-mi:Ap1m1(display_short)|uniprotkb:Cltnm(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin mu-1 subunit(gene name synonym)|uniprotkb:Mu-adaptin 1(gene name synonym)|uniprotkb:AP-mu chain family member mu1A(gene name synonym)|uniprotkb:Mu1A-adaptin(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP47(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP47(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit mu-1(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 mu-1 medium chain 1(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit mu-1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6868055|imex:IM-20905-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288140.1|ensembl:ENSMUSG00000031731(gene)|ensembl:ENSMUST00000034171(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005518"(collagen binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:P22892|rcsb pdb:1GYU|rcsb pdb:1GYV|rcsb pdb:1GYW|rcsb pdb:1W63|rcsb pdb:2A7B|rcsb pdb:3ZY7|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|go:"GO:0015630"(microtubule cytoskeleton)	refseq:NP_031482.1|ensembl:ENSMUSG00000003033(gene)|ensembl:ENSMUST00000003117(transcript)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032438"(melanosome organization)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR028565|interpro:IPR036168|mint:P35585|rcsb pdb:1W63|rcsb pdb:4EMZ|rcsb pdb:4EN2|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-6798695|dip:DIP-35323N	go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)	-	-	figure legend:Fig. 4  I-N|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2013/06/18	2014/10/16	rogid:VeKvrfk0rSWIQfepmlhaOm293MI10090	rogid:jng3stxfxbi8Emuhlquac0/JC0Q10090	intact-crc:0F9080B1E9A0D20E|rigid:DtGpsxbPUG/on0KAbXLq4gLTXQ0	false	mutation disrupting interaction strength:68-68,71-71,102-102|mcherry fluorescent protein tag:?-?|sufficient binding region:1-595	enhanced green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q10567	uniprotkb:O43747	intact:EBI-1171303|uniprotkb:P78436|uniprotkb:C9JRD1|uniprotkb:Q20WL3|intact:EBI-11577132|uniprotkb:F8WDL0|uniprotkb:Q86X54|ensembl:ENSP00000319361|ensembl:ENSP00000350199|ensembl:ENSP00000384194|ensembl:ENSP00000400065	intact:EBI-447609|uniprotkb:O75709|uniprotkb:O75842|uniprotkb:Q9UG09|uniprotkb:Q9Y3U4|ensembl:ENSP00000299980|ensembl:ENSP00000454523	psi-mi:ap1b1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit beta-1(gene name synonym)|uniprotkb:Beta-adaptin 1(gene name synonym)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta large chain(gene name synonym)|uniprotkb:AP1B1(gene name)|psi-mi:AP1B1(display_short)|uniprotkb:ADTB1(gene name synonym)|uniprotkb:BAM22(gene name synonym)|uniprotkb:CLAPB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit beta-1(gene name synonym)	psi-mi:ap1g1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:AP1G1(gene name)|psi-mi:AP1G1(display_short)|uniprotkb:ADTG(gene name synonym)|uniprotkb:CLAPG1(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6868018|imex:IM-20905-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001118.3|refseq:NP_663782.2|refseq:NP_001159491.1|ensembl:ENSG00000100280(gene)|ensembl:ENST00000317368(transcript)|ensembl:ENST00000357586(transcript)|ensembl:ENST00000405198(transcript)|ensembl:ENST00000432560(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q10567|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|rcsb pdb:6CRI|dip:DIP-24207N	refseq:NP_001025178.1|refseq:NP_001119.3|ensembl:ENSG00000166747(gene)|ensembl:ENST00000299980(transcript)|ensembl:ENST00000569748(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:O43747|rcsb pdb:1IU1|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722	go:"GO:0005802"(trans-Golgi network)|go:"GO:0005768"(endosome)	-	-	figure legend:Fig. 4C-H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2013/06/18	2016/02/11	rogid:D0i+5PXwzbBmOSyeCOSFKZx8fQk9606	rogid:E0niV91xZ1PV6Pr6Koq3Xs+9nKg9606	intact-crc:1C6B8BEA409ED476|rigid:08ypzuTdPVi0uG/SVuQXqbLcm+4	false	sufficient binding region:1-584|enhanced green fluorescent protein tag:?-?|mutation disrupting interaction strength:85-85,88-88	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:O75379	uniprotkb:P22892	intact:EBI-744953|uniprotkb:Q96IY9|uniprotkb:Q96J20|uniprotkb:Q9UEL7|uniprotkb:A2IDD8|ensembl:ENSP00000236192|ensembl:ENSP00000435933	intact:EBI-1040262|ensembl:ENSMUSP00000034171	psi-mi:vamp4_human(display_long)|uniprotkb:VAMP4(gene name)|psi-mi:VAMP4(display_short)	psi-mi:ap1g1_mouse(display_long)|uniprotkb:Ap1g1(gene name)|psi-mi:Ap1g1(display_short)|uniprotkb:Adtg(gene name synonym)|uniprotkb:Clapg1(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Gamma-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6868249|imex:IM-20905-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001172056.1|refseq:NP_003753.2|ensembl:ENSG00000117533(gene)|ensembl:ENST00000236192(transcript)|ensembl:ENST00000474047(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0030133"(transport vesicle)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR001388(Synaptobrevin)|interpro:IPR042855|interpro:IPR042887|mint:O75379|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-44226N	refseq:NP_001288140.1|ensembl:ENSMUSG00000031731(gene)|ensembl:ENSMUST00000034171(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005518"(collagen binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:P22892|rcsb pdb:1GYU|rcsb pdb:1GYV|rcsb pdb:1GYW|rcsb pdb:1W63|rcsb pdb:2A7B|rcsb pdb:3ZY7|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|go:"GO:0015630"(microtubule cytoskeleton)	-	-	-	figure legend:Fig. 5D|caution:Presence of the subunits demonstrated by Coomassie staining of the purified complex, however AP1S3 was not shown to be present. It has been included in this complex as it is present in the single polycistronic vector this complex was cloned into, and also because it was shown to be present in the crystal of this complex.|comment:Arf1 enhanced the binding of wild-type AP-1 to VAMP4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/18	2016/02/11	rogid:tITvmst+UYk596iJSowMT+R0U/89606	rogid:VeKvrfk0rSWIQfepmlhaOm293MI10090	intact-crc:020224801827991A|rigid:e8ljrMRlH1iCwxa3rEXGEE+gzPI	false	glutathione s tranferase tag:c-c|sufficient binding region:1-51	sufficient binding region:1-595|mutation disrupting interaction strength:68-68,71-71,102-102	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75379	uniprotkb:Q96PC3	intact:EBI-744953|uniprotkb:Q96IY9|uniprotkb:Q96J20|uniprotkb:Q9UEL7|uniprotkb:A2IDD8|ensembl:ENSP00000236192|ensembl:ENSP00000435933	intact:EBI-3923129|uniprotkb:Q8WTY1|uniprotkb:Q96DD1|uniprotkb:B4DQZ1|ensembl:ENSP00000388738	psi-mi:vamp4_human(display_long)|uniprotkb:VAMP4(gene name)|psi-mi:VAMP4(display_short)	psi-mi:ap1s3_human(display_long)|uniprotkb:AP1S3(gene name)|psi-mi:AP1S3(display_short)|uniprotkb:Clathrin assembly protein complex 1 sigma-1C small chain(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin sigma-1C subunit(gene name synonym)|uniprotkb:Sigma 1C subunit of AP-1 clathrin(gene name synonym)|uniprotkb:Sigma-adaptin 1C(gene name synonym)|uniprotkb:Sigma1C-adaptin(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit sigma-1C(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit sigma-1C(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6868249|imex:IM-20905-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001172056.1|refseq:NP_003753.2|ensembl:ENSG00000117533(gene)|ensembl:ENST00000236192(transcript)|ensembl:ENST00000474047(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0030133"(transport vesicle)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR001388(Synaptobrevin)|interpro:IPR042855|interpro:IPR042887|mint:O75379|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-44226N	refseq:NP_001034658.1|ensembl:ENSG00000152056(gene)|ensembl:ENST00000446015(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006605"(protein targeting)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR016635(Adaptor protein complex, sigma subunit)|interpro:IPR022775|interpro:IPR044733|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|go:"GO:0005829"(cytosol)|reactome:R-HSA-432722	-	-	-	figure legend:Fig. 5D|caution:Presence of the subunits demonstrated by Coomassie staining of the purified complex, however AP1S3 was not shown to be present. It has been included in this complex as it is present in the single polycistronic vector this complex was cloned into, and also because it was shown to be present in the crystal of this complex.|comment:Arf1 enhanced the binding of wild-type AP-1 to VAMP4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/18	2016/02/11	rogid:tITvmst+UYk596iJSowMT+R0U/89606	rogid:4mRBQXekmJl9Ln+Bfq+jJbSkD409606	intact-crc:020224801827991A|rigid:e8ljrMRlH1iCwxa3rEXGEE+gzPI	false	glutathione s tranferase tag:c-c|sufficient binding region:1-51	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75379	uniprotkb:P35585	intact:EBI-744953|uniprotkb:Q96IY9|uniprotkb:Q96J20|uniprotkb:Q9UEL7|uniprotkb:A2IDD8|ensembl:ENSP00000236192|ensembl:ENSP00000435933	intact:EBI-1040251|ensembl:ENSMUSP00000003117	psi-mi:vamp4_human(display_long)|uniprotkb:VAMP4(gene name)|psi-mi:VAMP4(display_short)	psi-mi:ap1m1_mouse(display_long)|uniprotkb:Ap1m1(gene name)|psi-mi:Ap1m1(display_short)|uniprotkb:Cltnm(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin mu-1 subunit(gene name synonym)|uniprotkb:Mu-adaptin 1(gene name synonym)|uniprotkb:AP-mu chain family member mu1A(gene name synonym)|uniprotkb:Mu1A-adaptin(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP47(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP47(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit mu-1(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 mu-1 medium chain 1(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit mu-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6868249|imex:IM-20905-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001172056.1|refseq:NP_003753.2|ensembl:ENSG00000117533(gene)|ensembl:ENST00000236192(transcript)|ensembl:ENST00000474047(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0030133"(transport vesicle)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR001388(Synaptobrevin)|interpro:IPR042855|interpro:IPR042887|mint:O75379|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-44226N	refseq:NP_031482.1|ensembl:ENSMUSG00000003033(gene)|ensembl:ENSMUST00000003117(transcript)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032438"(melanosome organization)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR028565|interpro:IPR036168|mint:P35585|rcsb pdb:1W63|rcsb pdb:4EMZ|rcsb pdb:4EN2|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-6798695|dip:DIP-35323N	-	-	-	figure legend:Fig. 5D|caution:Presence of the subunits demonstrated by Coomassie staining of the purified complex, however AP1S3 was not shown to be present. It has been included in this complex as it is present in the single polycistronic vector this complex was cloned into, and also because it was shown to be present in the crystal of this complex.|comment:Arf1 enhanced the binding of wild-type AP-1 to VAMP4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/18	2016/02/11	rogid:tITvmst+UYk596iJSowMT+R0U/89606	rogid:jng3stxfxbi8Emuhlquac0/JC0Q10090	intact-crc:020224801827991A|rigid:e8ljrMRlH1iCwxa3rEXGEE+gzPI	false	glutathione s tranferase tag:c-c|sufficient binding region:1-51	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75379	uniprotkb:Q10567	intact:EBI-744953|uniprotkb:Q96IY9|uniprotkb:Q96J20|uniprotkb:Q9UEL7|uniprotkb:A2IDD8|ensembl:ENSP00000236192|ensembl:ENSP00000435933	intact:EBI-1171303|uniprotkb:P78436|uniprotkb:C9JRD1|uniprotkb:Q20WL3|intact:EBI-11577132|uniprotkb:F8WDL0|uniprotkb:Q86X54|ensembl:ENSP00000319361|ensembl:ENSP00000350199|ensembl:ENSP00000384194|ensembl:ENSP00000400065	psi-mi:vamp4_human(display_long)|uniprotkb:VAMP4(gene name)|psi-mi:VAMP4(display_short)	psi-mi:ap1b1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit beta-1(gene name synonym)|uniprotkb:Beta-adaptin 1(gene name synonym)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta large chain(gene name synonym)|uniprotkb:AP1B1(gene name)|psi-mi:AP1B1(display_short)|uniprotkb:ADTB1(gene name synonym)|uniprotkb:BAM22(gene name synonym)|uniprotkb:CLAPB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit beta-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ren et al. (2013)	imex:IM-20905|pubmed:23415225	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6868249|imex:IM-20905-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001172056.1|refseq:NP_003753.2|ensembl:ENSG00000117533(gene)|ensembl:ENST00000236192(transcript)|ensembl:ENST00000474047(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0030133"(transport vesicle)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR001388(Synaptobrevin)|interpro:IPR042855|interpro:IPR042887|mint:O75379|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-44226N	refseq:NP_001118.3|refseq:NP_663782.2|refseq:NP_001159491.1|ensembl:ENSG00000100280(gene)|ensembl:ENST00000317368(transcript)|ensembl:ENST00000357586(transcript)|ensembl:ENST00000405198(transcript)|ensembl:ENST00000432560(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q10567|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|rcsb pdb:6CRI|dip:DIP-24207N	-	-	-	figure legend:Fig. 5D|caution:Presence of the subunits demonstrated by Coomassie staining of the purified complex, however AP1S3 was not shown to be present. It has been included in this complex as it is present in the single polycistronic vector this complex was cloned into, and also because it was shown to be present in the crystal of this complex.|comment:Arf1 enhanced the binding of wild-type AP-1 to VAMP4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/18	2016/02/11	rogid:tITvmst+UYk596iJSowMT+R0U/89606	rogid:D0i+5PXwzbBmOSyeCOSFKZx8fQk9606	intact-crc:020224801827991A|rigid:e8ljrMRlH1iCwxa3rEXGEE+gzPI	false	glutathione s tranferase tag:c-c|sufficient binding region:1-51	sufficient binding region:1-584|mutation decreasing interaction strength:85-85,88-88|his tag:n-n|mutation:488-488	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)