#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P01258 uniprotkb:P01258 intact:EBI-1018474|uniprotkb:Q13935|uniprotkb:Q13937|uniprotkb:Q52LX7|uniprotkb:B7ZL39|ensembl:ENSP00000331746|ensembl:ENSP00000379657 intact:EBI-1018474|uniprotkb:Q13935|uniprotkb:Q13937|uniprotkb:Q52LX7|uniprotkb:B7ZL39|ensembl:ENSP00000331746|ensembl:ENSP00000379657 psi-mi:calc_human(display_long)|uniprotkb:CALCA(gene name)|psi-mi:CALCA(display_short)|uniprotkb:CALC1(gene name synonym) psi-mi:calc_human(display_long)|uniprotkb:CALCA(gene name)|psi-mi:CALCA(display_short)|uniprotkb:CALC1(gene name synonym) psi-mi:"MI:0825"(x-ray fiber diffraction) Iconomidou et al. (2013) mint:d-12-01988r1|pubmed:23395606|mint:MINT-8409733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8398780|mint:MINT-8409770 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001029124.1|refseq:NP_001732.1|ensembl:ENSG00000110680(gene)|ensembl:ENST00000331587(transcript)|ensembl:ENST00000396372(transcript)|go:"GO:0001984"(artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007566"(embryo implantation)|go:"GO:0007631"(feeding behavior)|go:"GO:0007568"(aging)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009408"(response to heat)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0031716"(calcitonin receptor binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048265"(response to pain)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|interpro:IPR021118|mint:P01258|rcsb pdb:2JXZ|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225|refseq:XP_016873772.1|refseq:XP_016873773.1|mint:MINT-8409772(identity) refseq:NP_001029124.1|refseq:NP_001732.1|ensembl:ENSG00000110680(gene)|ensembl:ENST00000331587(transcript)|ensembl:ENST00000396372(transcript)|go:"GO:0001984"(artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007566"(embryo implantation)|go:"GO:0007631"(feeding behavior)|go:"GO:0007568"(aging)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009408"(response to heat)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0031716"(calcitonin receptor binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048265"(response to pain)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|interpro:IPR021118|mint:P01258|rcsb pdb:2JXZ|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225|refseq:XP_016873772.1|refseq:XP_016873773.1|mint:MINT-8409861(identity) - - - comment:homomint|comment:mint|figure legend:t1 f3 taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/15 2018/09/18 rogid:LMHetYvCTJzVQ6Gu2beLPywSwtg9606 rogid:LMHetYvCTJzVQ6Gu2beLPywSwtg9606 intact-crc:9EA86CC98206A306|rigid:NBEC8W6VubsURhGsX5/EeNpH/oU false binding-associated region:90-95(MINT-8409872) binding-associated region:90-95(MINT-8409868) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:P01258 uniprotkb:P01258 intact:EBI-1018474|uniprotkb:Q13935|uniprotkb:Q13937|uniprotkb:Q52LX7|uniprotkb:B7ZL39|ensembl:ENSP00000331746|ensembl:ENSP00000379657 intact:EBI-1018474|uniprotkb:Q13935|uniprotkb:Q13937|uniprotkb:Q52LX7|uniprotkb:B7ZL39|ensembl:ENSP00000331746|ensembl:ENSP00000379657 psi-mi:calc_human(display_long)|uniprotkb:CALCA(gene name)|psi-mi:CALCA(display_short)|uniprotkb:CALC1(gene name synonym) psi-mi:calc_human(display_long)|uniprotkb:CALCA(gene name)|psi-mi:CALCA(display_short)|uniprotkb:CALC1(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Iconomidou et al. (2013) mint:d-12-01988r1|pubmed:23395606|mint:MINT-8409733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8398807|mint:MINT-8409840 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001029124.1|refseq:NP_001732.1|ensembl:ENSG00000110680(gene)|ensembl:ENST00000331587(transcript)|ensembl:ENST00000396372(transcript)|go:"GO:0001984"(artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007566"(embryo implantation)|go:"GO:0007631"(feeding behavior)|go:"GO:0007568"(aging)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009408"(response to heat)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0031716"(calcitonin receptor binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048265"(response to pain)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|interpro:IPR021118|mint:P01258|rcsb pdb:2JXZ|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225|refseq:XP_016873772.1|refseq:XP_016873773.1|mint:MINT-8409849(identity) refseq:NP_001029124.1|refseq:NP_001732.1|ensembl:ENSG00000110680(gene)|ensembl:ENST00000331587(transcript)|ensembl:ENST00000396372(transcript)|go:"GO:0001984"(artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007566"(embryo implantation)|go:"GO:0007631"(feeding behavior)|go:"GO:0007568"(aging)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009408"(response to heat)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0031716"(calcitonin receptor binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048265"(response to pain)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|interpro:IPR021118|mint:P01258|rcsb pdb:2JXZ|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225|refseq:XP_016873772.1|refseq:XP_016873773.1|mint:MINT-8409842(identity) - - - figure legend:f2|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/15 2018/09/18 rogid:LMHetYvCTJzVQ6Gu2beLPywSwtg9606 rogid:LMHetYvCTJzVQ6Gu2beLPywSwtg9606 intact-crc:BA03B0E634129F32|rigid:NBEC8W6VubsURhGsX5/EeNpH/oU false binding-associated region:90-95(MINT-8409853) binding-associated region:90-95(MINT-8409857) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:P01258 uniprotkb:P01258 intact:EBI-1018474|uniprotkb:Q13935|uniprotkb:Q13937|uniprotkb:Q52LX7|uniprotkb:B7ZL39|ensembl:ENSP00000331746|ensembl:ENSP00000379657 intact:EBI-1018474|uniprotkb:Q13935|uniprotkb:Q13937|uniprotkb:Q52LX7|uniprotkb:B7ZL39|ensembl:ENSP00000331746|ensembl:ENSP00000379657 psi-mi:calc_human(display_long)|uniprotkb:CALCA(gene name)|psi-mi:CALCA(display_short)|uniprotkb:CALC1(gene name synonym) psi-mi:calc_human(display_long)|uniprotkb:CALCA(gene name)|psi-mi:CALCA(display_short)|uniprotkb:CALC1(gene name synonym) psi-mi:"MI:0964"(infrared spectroscopy) Iconomidou et al. (2013) mint:d-12-01988r1|pubmed:23395606|mint:MINT-8409733 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8398834|mint:MINT-8409885 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001029124.1|refseq:NP_001732.1|ensembl:ENSG00000110680(gene)|ensembl:ENST00000331587(transcript)|ensembl:ENST00000396372(transcript)|go:"GO:0001984"(artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007566"(embryo implantation)|go:"GO:0007631"(feeding behavior)|go:"GO:0007568"(aging)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009408"(response to heat)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0031716"(calcitonin receptor binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048265"(response to pain)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|interpro:IPR021118|mint:P01258|rcsb pdb:2JXZ|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225|refseq:XP_016873772.1|refseq:XP_016873773.1|mint:MINT-8409887(identity) refseq:NP_001029124.1|refseq:NP_001732.1|ensembl:ENSG00000110680(gene)|ensembl:ENST00000331587(transcript)|ensembl:ENST00000396372(transcript)|go:"GO:0001984"(artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007566"(embryo implantation)|go:"GO:0007631"(feeding behavior)|go:"GO:0007568"(aging)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009408"(response to heat)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0031716"(calcitonin receptor binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048265"(response to pain)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|interpro:IPR021118|mint:P01258|rcsb pdb:2JXZ|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225|refseq:XP_016873772.1|refseq:XP_016873773.1|mint:MINT-8409891(identity) - - - comment:homomint|comment:mint|figure legend:f4 t2 taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/01/15 2018/09/18 rogid:LMHetYvCTJzVQ6Gu2beLPywSwtg9606 rogid:LMHetYvCTJzVQ6Gu2beLPywSwtg9606 intact-crc:B547AB14B05A94DD|rigid:NBEC8W6VubsURhGsX5/EeNpH/oU false binding-associated region:90-95(MINT-8409888) binding-associated region:90-95(MINT-8409892) - - psi-mi:"MI:0083"(peptide synthesis) psi-mi:"MI:0083"(peptide synthesis)