#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P14270 uniprotkb:P08588 intact:EBI-8333209|uniprotkb:A1E347|uniprotkb:A1EC59|uniprotkb:F1M1H7|uniprotkb:O35470|intact:MINT-8432590|uniprotkb:Q6TRI0|uniprotkb:Q8CG04|uniprotkb:Q8CG06 intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4 psi-mi:pde4d_rat(display_long)|uniprotkb:Pde4d(gene name)|psi-mi:Pde4d(display_short)|uniprotkb:DPDE3(gene name synonym) psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Richter et al. (2013) pubmed:23381222|imex:IM-20889|mint:MINT-8428474 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8333204|mint:MINT-8432585|imex:IM-20889-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_008758943.1|refseq:XP_008758944.1|refseq:XP_008758945.1|refseq:NP_058728.1|refseq:NP_001106803.1|interpro:IPR023174|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR023088|refseq:NP_001106805.1|refseq:NP_001106799.1|refseq:NP_001106800.1|rgd:3281|reactome:R-RNO-180024|reactome:R-RNO-418555|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR036971|interpro:IPR040844|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0004112"(cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006198"(cAMP catabolic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030016"(myofibril)|go:"GO:0030324"(lung development)|go:"GO:0030552"(cAMP binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034622"|go:"GO:0034704"(calcium channel complex)|go:"GO:0034705"(potassium channel complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086024"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901363"(heterocyclic compound binding)|go:"GO:1901898"(negative regulation of relaxation of cardiac muscle)|mint:MINT-8433058(identity) refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N|mint:MINT-8432587(identity) - comment:mint - figure legend:f1a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/06/05 2014/10/16 rogid:tAcTCNfcSldJQPH0SuHYk+obwgY10116 rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606 intact-crc:442824A42584D62A|rigid:pXkmgfFD/R0jJjgziOzH9HWAvfg false myc tag:?-?(MINT-8433059) flag tag:?-?(MINT-8433063) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P14270 uniprotkb:P08588 intact:EBI-8333209|uniprotkb:A1E347|uniprotkb:A1EC59|uniprotkb:F1M1H7|uniprotkb:O35470|intact:MINT-8432590|uniprotkb:Q6TRI0|uniprotkb:Q8CG04|uniprotkb:Q8CG06 intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4 psi-mi:pde4d_rat(display_long)|uniprotkb:Pde4d(gene name)|psi-mi:Pde4d(display_short)|uniprotkb:DPDE3(gene name synonym) psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Richter et al. (2013) pubmed:23381222|imex:IM-20889|mint:MINT-8428474 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8333272|mint:MINT-8433068|imex:IM-20889-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_008758943.1|refseq:XP_008758944.1|refseq:XP_008758945.1|refseq:NP_058728.1|refseq:NP_001106803.1|interpro:IPR023174|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR023088|refseq:NP_001106805.1|refseq:NP_001106799.1|refseq:NP_001106800.1|rgd:3281|reactome:R-RNO-180024|reactome:R-RNO-418555|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR036971|interpro:IPR040844|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0004112"(cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006198"(cAMP catabolic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030016"(myofibril)|go:"GO:0030324"(lung development)|go:"GO:0030552"(cAMP binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034622"|go:"GO:0034704"(calcium channel complex)|go:"GO:0034705"(potassium channel complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086024"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901363"(heterocyclic compound binding)|go:"GO:1901898"(negative regulation of relaxation of cardiac muscle)|mint:MINT-8433070(identity) refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N|mint:MINT-8433074(identity) - comment:mint - figure legend:f1a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2013/06/05 2014/10/16 rogid:tAcTCNfcSldJQPH0SuHYk+obwgY10116 rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606 intact-crc:1D634362004ADB9B|rigid:pXkmgfFD/R0jJjgziOzH9HWAvfg false myc tag:?-?(MINT-8433071) flag tag:?-?(MINT-8433075) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)