#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8WXF8	uniprotkb:Q676U5	intact:EBI-5278558|uniprotkb:Q8NBR2|uniprotkb:Q8NES1|uniprotkb:Q8TAA8|uniprotkb:Q96D35|ensembl:ENSP00000470082|ensembl:ENSP00000471512	intact:EBI-535909|uniprotkb:Q6IPN1|uniprotkb:Q6UXW4|uniprotkb:Q6ZVZ5|uniprotkb:Q8NCY2|uniprotkb:Q96JV5|uniprotkb:Q9H619|uniprotkb:A3EXK9|uniprotkb:A3EXL0|uniprotkb:B6ZDH0|ensembl:ENSP00000375872|ensembl:ENSP00000487542	psi-mi:dedd2_human(display_long)|uniprotkb:DEDD2(gene name)|psi-mi:DEDD2(display_short)|uniprotkb:FLAME3(gene name synonym)|uniprotkb:DED-containing protein FLAME-3(gene name synonym)|uniprotkb:FADD-like anti-apoptotic molecule 3(gene name synonym)|uniprotkb:PSEC0004(orf name)	psi-mi:a16l1_human(display_long)|uniprotkb:APG16-like 1(gene name synonym)|uniprotkb:UNQ9393/PRO34307(orf name)|uniprotkb:ATG16L1(gene name)|psi-mi:ATG16L1(display_short)|uniprotkb:APG16L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boada-Romero et al. (2013)	pubmed:23376921|imex:IM-22530	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8843287|imex:IM-22530-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_579874.1|refseq:NP_001257543.1|refseq:NP_001257544.1|ensembl:ENSG00000160570(gene)|ensembl:ENST00000595337(transcript)|ensembl:ENST00000596251(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006396"(RNA processing)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001875(Death effector)|interpro:IPR011029(DEATH-like)|interpro:IPR038856|mint:Q8WXF8	refseq:NP_001177195.1|refseq:NP_001177196.1|refseq:NP_060444.3|refseq:NP_110430.5|refseq:NP_942593.2|dip:DIP-27552N|dip:DIP-50290N|ensembl:ENSG00000085978(gene)|ensembl:ENSG00000281089(gene)|ensembl:ENST00000392017(transcript)|ensembl:ENST00000625501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0098792"(xenophagy)|go:"GO:0120095"(vacuole-isolation membrane contact site)|interpro:IPR001680(WD40 repeat)|interpro:IPR013923(Autophagy protein 16)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q676U5|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|rcsb pdb:5NUV|rcsb pdb:5ZYX|reactome:R-HSA-1632852	-	comment:"This interaction was decreased in the case of the 4M derivatives (Figure 6B and C), arguing that it is mediated by the identified motif. Interestingly, the 263–281 peptide fused to GST sufficed to precipitate ATG16L1 and, again, the mutated version was inactive (Figure 6D)."	-	figure legend:f8g f8h|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/04	2014/10/16	rogid:KEvs0YThfzCArmJwoQF/bHHttZk9606	rogid:rLwpmIwMwd/GgPJA+7OKYTnn73E9606	intact-crc:B53C7F3F6E76D0A4|rigid:RZwhPYPex0FouLni1uJLm2elmGM	false	ha tag:?-?|sufficient binding region:12-24	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q676U5	uniprotkb:Q9Y228	intact:EBI-535909|uniprotkb:Q6IPN1|uniprotkb:Q6UXW4|uniprotkb:Q6ZVZ5|uniprotkb:Q8NCY2|uniprotkb:Q96JV5|uniprotkb:Q9H619|uniprotkb:A3EXK9|uniprotkb:A3EXL0|uniprotkb:B6ZDH0|ensembl:ENSP00000375872|ensembl:ENSP00000487542	intact:EBI-765817|uniprotkb:Q2YDB5|uniprotkb:A6NIU9|uniprotkb:Q4VY06|uniprotkb:Q7Z706|uniprotkb:A1L464|ensembl:ENSP00000355991|ensembl:ENSP00000355992	psi-mi:a16l1_human(display_long)|uniprotkb:APG16-like 1(gene name synonym)|uniprotkb:UNQ9393/PRO34307(orf name)|uniprotkb:ATG16L1(gene name)|psi-mi:ATG16L1(display_short)|uniprotkb:APG16L(gene name synonym)	psi-mi:t3jam_human(display_long)|uniprotkb:TRAF3-interacting protein 3(gene name synonym)|uniprotkb:TRAF3IP3(gene name)|psi-mi:TRAF3IP3(display_short)|uniprotkb:T3JAM(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boada-Romero et al. (2013)	pubmed:23376921|imex:IM-22530	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8843270|imex:IM-22530-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001177195.1|refseq:NP_001177196.1|refseq:NP_060444.3|refseq:NP_110430.5|refseq:NP_942593.2|dip:DIP-27552N|dip:DIP-50290N|ensembl:ENSG00000085978(gene)|ensembl:ENSG00000281089(gene)|ensembl:ENST00000392017(transcript)|ensembl:ENST00000625501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0098792"(xenophagy)|go:"GO:0120095"(vacuole-isolation membrane contact site)|interpro:IPR001680(WD40 repeat)|interpro:IPR013923(Autophagy protein 16)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q676U5|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|rcsb pdb:5NUV|rcsb pdb:5ZYX|reactome:R-HSA-1632852	refseq:NP_079504.2|refseq:NP_001274683.1|refseq:NP_001307072.1|refseq:NP_001307073.1|ensembl:ENSG00000009790(gene)|ensembl:ENST00000367024(transcript)|ensembl:ENST00000367025(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|mint:Q9Y228	-	-	comment:"This interaction was decreased in the case of the 4M derivatives (Figure 6B and C), arguing that it is mediated by the identified motif. Interestingly, the 263–281 peptide fused to GST sufficed to precipitate ATG16L1 and, again, the mutated version was inactive (Figure 6D)."	figure legend:f8g f8h|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/04	2014/10/16	rogid:rLwpmIwMwd/GgPJA+7OKYTnn73E9606	rogid:KDgxJv66FX+o56QzfysW3BS/tKc9606	intact-crc:6A2F9222A768E3C1|rigid:wSbZ+K13ORsrsNc3pyNKlkwIaTI	false	glutathione s tranferase tag:?-?	ha tag:?-?|sufficient binding region:318-332	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9HC29	uniprotkb:Q676U5	intact:EBI-7445625|uniprotkb:Q96RH5|uniprotkb:Q96RH8|uniprotkb:Q96RH6|uniprotkb:E2JEQ6|intact:MINT-151071|ensembl:ENSP00000300589	intact:EBI-535909|uniprotkb:Q6IPN1|uniprotkb:Q6UXW4|uniprotkb:Q6ZVZ5|uniprotkb:Q8NCY2|uniprotkb:Q96JV5|uniprotkb:Q9H619|uniprotkb:A3EXK9|uniprotkb:A3EXL0|uniprotkb:B6ZDH0|ensembl:ENSP00000375872|ensembl:ENSP00000487542	psi-mi:nod2_human(display_long)|uniprotkb:IBD1(gene name synonym)|uniprotkb:NOD2(gene name)|psi-mi:NOD2(display_short)|uniprotkb:CARD15(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 15(gene name synonym)|uniprotkb:Inflammatory bowel disease protein 1(gene name synonym)	psi-mi:a16l1_human(display_long)|uniprotkb:APG16-like 1(gene name synonym)|uniprotkb:UNQ9393/PRO34307(orf name)|uniprotkb:ATG16L1(gene name)|psi-mi:ATG16L1(display_short)|uniprotkb:APG16L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boada-Romero et al. (2013)	pubmed:23376921|imex:IM-22530	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8842111|imex:IM-22530-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071445.1|refseq:XP_005256141.1|ensembl:ENSG00000167207(gene)|ensembl:ENST00000300589(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0002253"(activation of immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002710"(negative regulation of T cell mediated immunity)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031982"(vesicle)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0005856"(cytoskeleton)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0005886"(plasma membrane)|go:"GO:0032498"(detection of muramyl dipeptide)|go:"GO:0032500"(muramyl dipeptide binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032701"(negative regulation of interleukin-18 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0006952"(defense response)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0006965"(positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007584"(response to nutrient)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046645"(positive regulation of gamma-delta T cell activation)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060585"(positive regulation of prostaglandin-endoperoxide synthase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090022"(regulation of neutrophil chemotaxis)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|go:"GO:2000363"(positive regulation of prostaglandin-E synthase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|mint:Q9HC29|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:NP_001280486.1|dip:DIP-41998N	refseq:NP_001177195.1|refseq:NP_001177196.1|refseq:NP_060444.3|refseq:NP_110430.5|refseq:NP_942593.2|dip:DIP-27552N|dip:DIP-50290N|ensembl:ENSG00000085978(gene)|ensembl:ENSG00000281089(gene)|ensembl:ENST00000392017(transcript)|ensembl:ENST00000625501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0098792"(xenophagy)|go:"GO:0120095"(vacuole-isolation membrane contact site)|interpro:IPR001680(WD40 repeat)|interpro:IPR013923(Autophagy protein 16)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q676U5|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|rcsb pdb:5NUV|rcsb pdb:5ZYX|reactome:R-HSA-1632852	-	comment:mint|comment:homomint|function:"Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS)"|function:"Defects in NOD2 are the cause of Blau syndrome (BS) [MIM:186580]. BS is a rare autosomal dominant disorder characterized by early-onset granulomatous arthritis, uveitis and skin rash"|function:"Defects in NOD2 are a cause of susceptibility to Crohn disease (CD) [MIM:266600]. CD is a form of remitting inflammatory bowel disease (IBD). CD may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous. Crohn disease is commonly classified as autoimmune disease"|function:"Defects in NOD2 are a cause of susceptibility to ulcerative colitis [MIM:191390]. It is a chronic inflammatory bowel disease. In ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers. Ulcerative colitis is commonly classified as autoimmune disease"|function:"Defects in NOD2 are the cause of early-onset sarcoidosis (EOS) [MIM:609464]. Sarcoidosis is a multiorganic inflammatory disease with unknown etiology, characterized by the histologic features of non-caseating epithelioid granulomas. In childhood, 2 distinct types of sarcoidosis have been described. Usually the disease is detected in older children by chest radiography and the clinical manifestations are characterized by a classical triad of lung, lymph node, and eye involvement, similar to those in adults. In contrast, early-onset sarcoidosis (EOS), which usually appears in those younger than 4 years of age, is quite rare and has a distinct triad of skin, joint, and eye disorders, without apparent pulmonary involvement. Compared with an asymptomatic and sometimes naturally disappearing course of the disease in older children, EOS is progressive and in many cases causes severe complications, such as blindness, joint destruction, and visceral involvement"	-	figure legend:f8c F8E sf15a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/04	2014/10/16	rogid:cEF3hnDQW90TWXNDH/uqW6/wMhI9606	rogid:rLwpmIwMwd/GgPJA+7OKYTnn73E9606	intact-crc:00E4B2A34CCE68E3|rigid:v9jbCfzkZwOoJ6z2K7VaC44vKKs	false	sufficient binding region:1-122|ha tag:?-?|mutation decreasing interaction:77-77,74-74,72-72,71-71,70-70,69-69,68-68,64-64,63-63	glutathione s tranferase tag:?-?|necessary binding region:320-607	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BXS4	uniprotkb:Q676U5	intact:EBI-7054441|ensembl:ENSP00000234831|uniprotkb:Q4VBP9|uniprotkb:O75393|intact:MINT-8201752|uniprotkb:Q96KX7|uniprotkb:Q5T705|uniprotkb:B3KQL7	intact:EBI-535909|uniprotkb:Q6IPN1|uniprotkb:Q6UXW4|uniprotkb:Q6ZVZ5|uniprotkb:Q8NCY2|uniprotkb:Q96JV5|uniprotkb:Q9H619|uniprotkb:A3EXK9|uniprotkb:A3EXL0|uniprotkb:B6ZDH0|ensembl:ENSP00000375872|ensembl:ENSP00000487542	psi-mi:tmm59_human(display_long)|uniprotkb:TMEM59(gene name)|psi-mi:TMEM59(display_short)|uniprotkb:C1orf8(gene name synonym)|uniprotkb:Liver membrane-bound protein(gene name synonym)|uniprotkb:HSPC001(orf name)|uniprotkb:UNQ169/PRO195(orf name)	psi-mi:a16l1_human(display_long)|uniprotkb:APG16-like 1(gene name synonym)|uniprotkb:UNQ9393/PRO34307(orf name)|uniprotkb:ATG16L1(gene name)|psi-mi:ATG16L1(display_short)|uniprotkb:APG16L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boada-Romero et al. (2013)	pubmed:23376921|imex:IM-22530	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8842099|imex:IM-22530-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291972.1|refseq:NP_001291978.1|refseq:NP_001291979.1|refseq:NP_001291980.1|refseq:NP_001291981.1|refseq:NP_001291995.1|ensembl:ENSG00000116209(gene)|ensembl:ENST00000234831(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000138"(Golgi trans cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090285"(negative regulation of protein glycosylation in Golgi)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR022065|mint:Q9BXS4|reactome:R-HSA-9013407|reactome:R-HSA-9696273|refseq:NP_004863.2	refseq:NP_001177195.1|refseq:NP_001177196.1|refseq:NP_060444.3|refseq:NP_110430.5|refseq:NP_942593.2|dip:DIP-27552N|dip:DIP-50290N|ensembl:ENSG00000085978(gene)|ensembl:ENSG00000281089(gene)|ensembl:ENST00000392017(transcript)|ensembl:ENST00000625501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0098792"(xenophagy)|go:"GO:0120095"(vacuole-isolation membrane contact site)|interpro:IPR001680(WD40 repeat)|interpro:IPR013923(Autophagy protein 16)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q676U5|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|rcsb pdb:5NUV|rcsb pdb:5ZYX|reactome:R-HSA-1632852	-	comment:mint|comment:"Coimmunoprecipitation studies showed that the WD domain is both necessary (Figure 7A and B) and sufficient (Figure 7C and D) for interaction with TMEM59 through the ATG16L1-binding motif (Figure 7E and F)."	-	figure legend:f7b f7d f7f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/04	2014/10/16	rogid:yA2dq3FVXnxw9Peh6f3UBqGzFpM9606	rogid:rLwpmIwMwd/GgPJA+7OKYTnn73E9606	intact-crc:EE3C4AD008ADFA35|rigid:5X+nhY8Z2XMUT99VsCJfwHMb0fI	false	mutation disrupting interaction:268-268,277-277,280-280,272-272	necessary binding region:320-607|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BXS4	uniprotkb:Q676U5	intact:EBI-7054441|ensembl:ENSP00000234831|uniprotkb:Q4VBP9|uniprotkb:O75393|intact:MINT-8201752|uniprotkb:Q96KX7|uniprotkb:Q5T705|uniprotkb:B3KQL7	intact:EBI-535909|uniprotkb:Q6IPN1|uniprotkb:Q6UXW4|uniprotkb:Q6ZVZ5|uniprotkb:Q8NCY2|uniprotkb:Q96JV5|uniprotkb:Q9H619|uniprotkb:A3EXK9|uniprotkb:A3EXL0|uniprotkb:B6ZDH0|ensembl:ENSP00000375872|ensembl:ENSP00000487542	psi-mi:tmm59_human(display_long)|uniprotkb:TMEM59(gene name)|psi-mi:TMEM59(display_short)|uniprotkb:C1orf8(gene name synonym)|uniprotkb:Liver membrane-bound protein(gene name synonym)|uniprotkb:HSPC001(orf name)|uniprotkb:UNQ169/PRO195(orf name)	psi-mi:a16l1_human(display_long)|uniprotkb:APG16-like 1(gene name synonym)|uniprotkb:UNQ9393/PRO34307(orf name)|uniprotkb:ATG16L1(gene name)|psi-mi:ATG16L1(display_short)|uniprotkb:APG16L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boada-Romero et al. (2013)	pubmed:23376921|imex:IM-22530	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8842001|imex:IM-22530-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291972.1|refseq:NP_001291978.1|refseq:NP_001291979.1|refseq:NP_001291980.1|refseq:NP_001291981.1|refseq:NP_001291995.1|ensembl:ENSG00000116209(gene)|ensembl:ENST00000234831(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000138"(Golgi trans cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090285"(negative regulation of protein glycosylation in Golgi)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR022065|mint:Q9BXS4|reactome:R-HSA-9013407|reactome:R-HSA-9696273|refseq:NP_004863.2	refseq:NP_001177195.1|refseq:NP_001177196.1|refseq:NP_060444.3|refseq:NP_110430.5|refseq:NP_942593.2|dip:DIP-27552N|dip:DIP-50290N|ensembl:ENSG00000085978(gene)|ensembl:ENSG00000281089(gene)|ensembl:ENST00000392017(transcript)|ensembl:ENST00000625501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0098792"(xenophagy)|go:"GO:0120095"(vacuole-isolation membrane contact site)|interpro:IPR001680(WD40 repeat)|interpro:IPR013923(Autophagy protein 16)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q676U5|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|rcsb pdb:5NUV|rcsb pdb:5ZYX|reactome:R-HSA-1632852	-	comment:mint|comment:"This interaction was decreased in the case of the 4M derivatives (Figure 6B and C), arguing that it is mediated by the identified motif. Interestingly, the 263–281 peptide fused to GST sufficed to precipitate ATG16L1 and, again, the mutated version was inactive (Figure 6D)."	-	figure legend:f6c sf16b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/04	2014/10/16	rogid:yA2dq3FVXnxw9Peh6f3UBqGzFpM9606	rogid:rLwpmIwMwd/GgPJA+7OKYTnn73E9606	intact-crc:9254D7BB93848640|rigid:5X+nhY8Z2XMUT99VsCJfwHMb0fI	false	necessary binding region:268-323|mutation disrupting interaction:268-268,272-272,277-277,280-280	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BXS4	uniprotkb:Q676U5	intact:EBI-7054441|ensembl:ENSP00000234831|uniprotkb:Q4VBP9|uniprotkb:O75393|intact:MINT-8201752|uniprotkb:Q96KX7|uniprotkb:Q5T705|uniprotkb:B3KQL7	intact:EBI-535909|uniprotkb:Q6IPN1|uniprotkb:Q6UXW4|uniprotkb:Q6ZVZ5|uniprotkb:Q8NCY2|uniprotkb:Q96JV5|uniprotkb:Q9H619|uniprotkb:A3EXK9|uniprotkb:A3EXL0|uniprotkb:B6ZDH0|ensembl:ENSP00000375872|ensembl:ENSP00000487542	psi-mi:tmm59_human(display_long)|uniprotkb:TMEM59(gene name)|psi-mi:TMEM59(display_short)|uniprotkb:C1orf8(gene name synonym)|uniprotkb:Liver membrane-bound protein(gene name synonym)|uniprotkb:HSPC001(orf name)|uniprotkb:UNQ169/PRO195(orf name)	psi-mi:a16l1_human(display_long)|uniprotkb:APG16-like 1(gene name synonym)|uniprotkb:UNQ9393/PRO34307(orf name)|uniprotkb:ATG16L1(gene name)|psi-mi:ATG16L1(display_short)|uniprotkb:APG16L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boada-Romero et al. (2013)	pubmed:23376921|imex:IM-22530	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8841987|imex:IM-22530-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291972.1|refseq:NP_001291978.1|refseq:NP_001291979.1|refseq:NP_001291980.1|refseq:NP_001291981.1|refseq:NP_001291995.1|ensembl:ENSG00000116209(gene)|ensembl:ENST00000234831(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000138"(Golgi trans cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090285"(negative regulation of protein glycosylation in Golgi)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR022065|mint:Q9BXS4|reactome:R-HSA-9013407|reactome:R-HSA-9696273|refseq:NP_004863.2	refseq:NP_001177195.1|refseq:NP_001177196.1|refseq:NP_060444.3|refseq:NP_110430.5|refseq:NP_942593.2|dip:DIP-27552N|dip:DIP-50290N|ensembl:ENSG00000085978(gene)|ensembl:ENSG00000281089(gene)|ensembl:ENST00000392017(transcript)|ensembl:ENST00000625501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0098792"(xenophagy)|go:"GO:0120095"(vacuole-isolation membrane contact site)|interpro:IPR001680(WD40 repeat)|interpro:IPR013923(Autophagy protein 16)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q676U5|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|rcsb pdb:5NUV|rcsb pdb:5ZYX|reactome:R-HSA-1632852	-	comment:mint|comment:"This interaction was decreased in the case of the 4M derivatives (Figure 6B and C), arguing that it is mediated by the identified motif. Interestingly, the 263–281 peptide fused to GST sufficed to precipitate ATG16L1 and, again, the mutated version was inactive (Figure 6D)."	-	figure legend:f6b f6d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/04	2014/10/16	rogid:yA2dq3FVXnxw9Peh6f3UBqGzFpM9606	rogid:rLwpmIwMwd/GgPJA+7OKYTnn73E9606	intact-crc:A78393826E464AF6|rigid:5X+nhY8Z2XMUT99VsCJfwHMb0fI	false	glutathione s tranferase tag:?-?|sufficient binding region:263-281|mutation disrupting interaction:268-268,277-277,272-272,280-280	au1 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BXS4	uniprotkb:Q9BXS5	intact:EBI-7054441|ensembl:ENSP00000234831|uniprotkb:Q4VBP9|uniprotkb:O75393|intact:MINT-8201752|uniprotkb:Q96KX7|uniprotkb:Q5T705|uniprotkb:B3KQL7	intact:EBI-541426|ensembl:ENSP00000291439|uniprotkb:Q4TTY5	psi-mi:tmm59_human(display_long)|uniprotkb:TMEM59(gene name)|psi-mi:TMEM59(display_short)|uniprotkb:C1orf8(gene name synonym)|uniprotkb:Liver membrane-bound protein(gene name synonym)|uniprotkb:HSPC001(orf name)|uniprotkb:UNQ169/PRO195(orf name)	psi-mi:ap1m1_human(display_long)|uniprotkb:Golgi adaptor HA1/AP1 adaptin mu-1 subunit(gene name synonym)|uniprotkb:Mu-adaptin 1(gene name synonym)|uniprotkb:AP-mu chain family member mu1A(gene name synonym)|uniprotkb:Mu1A-adaptin(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP47(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP47(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit mu-1(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 mu-1 medium chain 1(gene name synonym)|uniprotkb:AP1M1(gene name)|psi-mi:AP1M1(display_short)|uniprotkb:CLTNM(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit mu-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boada-Romero et al. (2013)	pubmed:23376921|imex:IM-22530	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8843036|imex:IM-22530-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291972.1|refseq:NP_001291978.1|refseq:NP_001291979.1|refseq:NP_001291980.1|refseq:NP_001291981.1|refseq:NP_001291995.1|ensembl:ENSG00000116209(gene)|ensembl:ENST00000234831(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000138"(Golgi trans cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090285"(negative regulation of protein glycosylation in Golgi)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR022065|mint:Q9BXS4|reactome:R-HSA-9013407|reactome:R-HSA-9696273|refseq:NP_004863.2	refseq:NP_115882.1|ensembl:ENSG00000072958(gene)|ensembl:ENST00000291439(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032438"(melanosome organization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR028565|interpro:IPR036168|mint:Q9BXS5|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6798695|refseq:NP_001123996.1	-	comment:mint|comment:"Coimmunoprecipitation studies showed that the WD domain is both necessary (Figure 7A and B) and sufficient (Figure 7C and D) for interaction with TMEM59 through the ATG16L1-binding motif (Figure 7E and F)."	-	figure legend:sf14a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/04	2014/10/16	rogid:yA2dq3FVXnxw9Peh6f3UBqGzFpM9606	rogid:B6OVovdusOdmvB0D+RIyhRRga2Q9606	intact-crc:DB7094E87D47E053|rigid:DiHDPwRKSW2Pn4tD29QPAx8v7m0	false	glutathione s tranferase tag:?-?|mutation disrupting interaction:272-272,268-268,277-277,280-280	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BXS4	uniprotkb:Q676U5	intact:EBI-7054441|ensembl:ENSP00000234831|uniprotkb:Q4VBP9|uniprotkb:O75393|intact:MINT-8201752|uniprotkb:Q96KX7|uniprotkb:Q5T705|uniprotkb:B3KQL7	intact:EBI-535909|uniprotkb:Q6IPN1|uniprotkb:Q6UXW4|uniprotkb:Q6ZVZ5|uniprotkb:Q8NCY2|uniprotkb:Q96JV5|uniprotkb:Q9H619|uniprotkb:A3EXK9|uniprotkb:A3EXL0|uniprotkb:B6ZDH0|ensembl:ENSP00000375872|ensembl:ENSP00000487542	psi-mi:tmm59_human(display_long)|uniprotkb:TMEM59(gene name)|psi-mi:TMEM59(display_short)|uniprotkb:C1orf8(gene name synonym)|uniprotkb:Liver membrane-bound protein(gene name synonym)|uniprotkb:HSPC001(orf name)|uniprotkb:UNQ169/PRO195(orf name)	psi-mi:a16l1_human(display_long)|uniprotkb:APG16-like 1(gene name synonym)|uniprotkb:UNQ9393/PRO34307(orf name)|uniprotkb:ATG16L1(gene name)|psi-mi:ATG16L1(display_short)|uniprotkb:APG16L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boada-Romero et al. (2013)	pubmed:23376921|imex:IM-22530	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8842085|imex:IM-22530-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291972.1|refseq:NP_001291978.1|refseq:NP_001291979.1|refseq:NP_001291980.1|refseq:NP_001291981.1|refseq:NP_001291995.1|ensembl:ENSG00000116209(gene)|ensembl:ENST00000234831(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000138"(Golgi trans cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090285"(negative regulation of protein glycosylation in Golgi)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR022065|mint:Q9BXS4|reactome:R-HSA-9013407|reactome:R-HSA-9696273|refseq:NP_004863.2	refseq:NP_001177195.1|refseq:NP_001177196.1|refseq:NP_060444.3|refseq:NP_110430.5|refseq:NP_942593.2|dip:DIP-27552N|dip:DIP-50290N|ensembl:ENSG00000085978(gene)|ensembl:ENSG00000281089(gene)|ensembl:ENST00000392017(transcript)|ensembl:ENST00000625501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0098792"(xenophagy)|go:"GO:0120095"(vacuole-isolation membrane contact site)|interpro:IPR001680(WD40 repeat)|interpro:IPR013923(Autophagy protein 16)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q676U5|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|rcsb pdb:5NUV|rcsb pdb:5ZYX|reactome:R-HSA-1632852	-	comment:mint|comment:"Coimmunoprecipitation studies showed that the WD domain is both necessary (Figure 7A and B) and sufficient (Figure 7C and D) for interaction with TMEM59 through the ATG16L1-binding motif (Figure 7E and F)."	-	figure legend:f7a f7c f7e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/04	2014/10/16	rogid:yA2dq3FVXnxw9Peh6f3UBqGzFpM9606	rogid:rLwpmIwMwd/GgPJA+7OKYTnn73E9606	intact-crc:E968D09904CE044D|rigid:5X+nhY8Z2XMUT99VsCJfwHMb0fI	false	glutathione s tranferase tag:?-?|mutation disrupting interaction:272-272,268-268,277-277,280-280	necessary binding region:320-607|ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BXS4	uniprotkb:Q96CW1	intact:EBI-7054441|ensembl:ENSP00000234831|uniprotkb:Q4VBP9|uniprotkb:O75393|intact:MINT-8201752|uniprotkb:Q96KX7|uniprotkb:Q5T705|uniprotkb:B3KQL7	intact:EBI-297683|ensembl:ENSP00000292807|uniprotkb:A6NE12|uniprotkb:P20172|uniprotkb:P53679|uniprotkb:D3DNT1	psi-mi:tmm59_human(display_long)|uniprotkb:TMEM59(gene name)|psi-mi:TMEM59(display_short)|uniprotkb:C1orf8(gene name synonym)|uniprotkb:Liver membrane-bound protein(gene name synonym)|uniprotkb:HSPC001(orf name)|uniprotkb:UNQ169/PRO195(orf name)	psi-mi:ap2m1_human(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit mu(gene name synonym)|uniprotkb:AP-2 mu chain(gene name synonym)|uniprotkb:AP2M1(gene name)|psi-mi:AP2M1(display_short)|uniprotkb:CLAPM1(gene name synonym)|uniprotkb:KIAA0109(gene name synonym)|uniprotkb:Adaptin-mu2(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)|uniprotkb:HA2 50 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit mu(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boada-Romero et al. (2013)	pubmed:23376921|imex:IM-22530	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8843050|imex:IM-22530-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291972.1|refseq:NP_001291978.1|refseq:NP_001291979.1|refseq:NP_001291980.1|refseq:NP_001291981.1|refseq:NP_001291995.1|ensembl:ENSG00000116209(gene)|ensembl:ENST00000234831(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000138"(Golgi trans cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090285"(negative regulation of protein glycosylation in Golgi)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR022065|mint:Q9BXS4|reactome:R-HSA-9013407|reactome:R-HSA-9696273|refseq:NP_004863.2	ensembl:ENSG00000161203(gene)|ensembl:ENST00000292807(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0034622"|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0031623"(receptor internalization)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|interpro:IPR043512|interpro:IPR043532|mint:Q96CW1|rcsb pdb:1H6E|rcsb pdb:6BNT|rcsb pdb:6URI|reactome:R-HSA-164939|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|reactome:R-HSA-182218|refseq:NP_001020376.1|refseq:NP_004059.2|refseq:NP_001298127.1	-	comment:mint|comment:"Coimmunoprecipitation studies showed that the WD domain is both necessary (Figure 7A and B) and sufficient (Figure 7C and D) for interaction with TMEM59 through the ATG16L1-binding motif (Figure 7E and F)."	-	figure legend:sf14b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/04	2014/10/16	rogid:yA2dq3FVXnxw9Peh6f3UBqGzFpM9606	rogid:AyJEJTqzHtIRWEnMGBzLQP3H5lA9606	intact-crc:D8CB11DA5B23B9BD|rigid:pVxnbknqlSo/06wi7HHVxkWwZlw	false	glutathione s tranferase tag:?-?|mutation disrupting interaction:272-272,277-277,268-268,280-280	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60603	uniprotkb:Q676U5	intact:EBI-973722|ensembl:ENSP00000260010|ensembl:ENSP00000494425|ensembl:ENSP00000495339|uniprotkb:O15454|uniprotkb:Q8NI00|uniprotkb:B3Y612|uniprotkb:D1CS45|uniprotkb:D1CS48|uniprotkb:D1CS49	intact:EBI-535909|uniprotkb:Q6IPN1|uniprotkb:Q6UXW4|uniprotkb:Q6ZVZ5|uniprotkb:Q8NCY2|uniprotkb:Q96JV5|uniprotkb:Q9H619|uniprotkb:A3EXK9|uniprotkb:A3EXL0|uniprotkb:B6ZDH0|ensembl:ENSP00000375872|ensembl:ENSP00000487542	psi-mi:tlr2_human(display_long)|uniprotkb:Toll/interleukin-1 receptor-like protein 4(gene name synonym)|uniprotkb:TLR2(gene name)|psi-mi:TLR2(display_short)|uniprotkb:TIL4(gene name synonym)	psi-mi:a16l1_human(display_long)|uniprotkb:APG16-like 1(gene name synonym)|uniprotkb:UNQ9393/PRO34307(orf name)|uniprotkb:ATG16L1(gene name)|psi-mi:ATG16L1(display_short)|uniprotkb:APG16L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boada-Romero et al. (2013)	pubmed:23376921|imex:IM-22530	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8842124|imex:IM-22530-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137462(gene)|ensembl:ENST00000260010(transcript)|ensembl:ENST00000642580(transcript)|ensembl:ENST00000642700(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032570"(response to progesterone)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|mint:O60603|rcsb pdb:1FYW|rcsb pdb:1FYX|rcsb pdb:1O77|rcsb pdb:2Z7X|rcsb pdb:2Z80|rcsb pdb:6NIG|reactome:R-HSA-1461957|reactome:R-HSA-166058|reactome:R-HSA-168179|reactome:R-HSA-168188|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9637628|reactome:R-HSA-1236974|refseq:NP_003255.2|refseq:XP_011530517.1|refseq:XP_011530518.1|refseq:XP_016864062.1|refseq:XP_016864063.1|refseq:XP_016864064.1|refseq:XP_016864065.1|refseq:NP_001305716.1|refseq:NP_001305718.1|refseq:NP_001305719.1|refseq:NP_001305720.1|refseq:NP_001305722.1|refseq:NP_001305725.1|refseq:NP_001305724.1|dip:DIP-35138N	refseq:NP_001177195.1|refseq:NP_001177196.1|refseq:NP_060444.3|refseq:NP_110430.5|refseq:NP_942593.2|dip:DIP-27552N|dip:DIP-50290N|ensembl:ENSG00000085978(gene)|ensembl:ENSG00000281089(gene)|ensembl:ENST00000392017(transcript)|ensembl:ENST00000625501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0098792"(xenophagy)|go:"GO:0120095"(vacuole-isolation membrane contact site)|interpro:IPR001680(WD40 repeat)|interpro:IPR013923(Autophagy protein 16)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q676U5|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|rcsb pdb:5NUV|rcsb pdb:5ZYX|reactome:R-HSA-1632852	-	comment:"This interaction was decreased in the case of the 4M derivatives (Figure 6B and C), arguing that it is mediated by the identified motif. Interestingly, the 263–281 peptide fused to GST sufficed to precipitate ATG16L1 and, again, the mutated version was inactive (Figure 6D)."	-	figure legend:f8d f8e sf15b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/04	2014/10/16	rogid:6xdppMwVYR7qWpDocSsqwvocdU89606	rogid:rLwpmIwMwd/GgPJA+7OKYTnn73E9606	intact-crc:94122BC6649E86DE|rigid:PKVp82e8077dS8Nou1LyRK6tA5Q	false	sufficient binding region:761-778|ha tag:?-?	necessary binding region:320-607|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BXS4	uniprotkb:Q9H492	intact:EBI-7054441|ensembl:ENSP00000234831|uniprotkb:Q4VBP9|uniprotkb:O75393|intact:MINT-8201752|uniprotkb:Q96KX7|uniprotkb:Q5T705|uniprotkb:B3KQL7	intact:EBI-720768|intact:EBI-28977435|ensembl:ENSP00000353886|ensembl:ENSP00000380821|uniprotkb:Q9BXW5|uniprotkb:E1P5P4|uniprotkb:E1P5P5	psi-mi:tmm59_human(display_long)|uniprotkb:TMEM59(gene name)|psi-mi:TMEM59(display_short)|uniprotkb:C1orf8(gene name synonym)|uniprotkb:Liver membrane-bound protein(gene name synonym)|uniprotkb:HSPC001(orf name)|uniprotkb:UNQ169/PRO195(orf name)	psi-mi:mlp3a_human(display_long)|uniprotkb:Microtubule-associated protein 1 light chain 3 alpha(gene name synonym)|uniprotkb:MAP1A/MAP1B light chain 3 A(gene name synonym)|uniprotkb:MAP1 light chain 3-like protein 1(gene name synonym)|uniprotkb:Autophagy-related protein LC3 A(gene name synonym)|uniprotkb:Autophagy-related ubiquitin-like modifier LC3 A(gene name synonym)|uniprotkb:MAP1LC3A(gene name)|psi-mi:MAP1LC3A(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Boada-Romero et al. (2013)	pubmed:23376921|imex:IM-22530	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8843159|imex:IM-22530-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291972.1|refseq:NP_001291978.1|refseq:NP_001291979.1|refseq:NP_001291980.1|refseq:NP_001291981.1|refseq:NP_001291995.1|ensembl:ENSG00000116209(gene)|ensembl:ENST00000234831(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000138"(Golgi trans cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090285"(negative regulation of protein glycosylation in Golgi)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR022065|mint:Q9BXS4|reactome:R-HSA-9013407|reactome:R-HSA-9696273|refseq:NP_004863.2	ensembl:ENSG00000101460(gene)|ensembl:ENST00000360668(transcript)|ensembl:ENST00000397709(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010288"(response to lead ion)|go:"GO:0016236"(macroautophagy)|go:"GO:0031090"(organelle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0044754"(autolysosome)|go:"GO:0045202"(synapse)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|mint:Q9H492|rcsb pdb:3ECI|rcsb pdb:3WAL|rcsb pdb:3WAN|rcsb pdb:4ZDV|rcsb pdb:5CX3|rcsb pdb:5DPR|rcsb pdb:6TBE|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|refseq:NP_115903.1|refseq:NP_852610.1|ensembl:ENSP00000353886|ensembl:ENST00000374837|ensembl:ENSP00000363970|ensembl:ENSP00000380821|dip:DIP-49052N	go:"GO:0031410"(cytoplasmic vesicle)	comment:mint|comment:"This interaction was decreased in the case of the 4M derivatives (Figure 6B and C), arguing that it is mediated by the identified motif. Interestingly, the 263–281 peptide fused to GST sufficed to precipitate ATG16L1 and, again, the mutated version was inactive (Figure 6D)."	-	figure legend:sf10c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/11/04	2014/10/16	rogid:yA2dq3FVXnxw9Peh6f3UBqGzFpM9606	rogid:qtZ3YM26FhxTs/gW+KFMllsVhn49606	intact-crc:2BC58EB476323FC9|rigid:+fYH5PZ+v7pGY7tXug3N7GKrgh8	false	mutation disrupting interaction:268-268,272-272,277-277,280-280	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9BXS4	uniprotkb:Q676U5	intact:EBI-7054441|ensembl:ENSP00000234831|uniprotkb:Q4VBP9|uniprotkb:O75393|intact:MINT-8201752|uniprotkb:Q96KX7|uniprotkb:Q5T705|uniprotkb:B3KQL7	intact:EBI-535909|uniprotkb:Q6IPN1|uniprotkb:Q6UXW4|uniprotkb:Q6ZVZ5|uniprotkb:Q8NCY2|uniprotkb:Q96JV5|uniprotkb:Q9H619|uniprotkb:A3EXK9|uniprotkb:A3EXL0|uniprotkb:B6ZDH0|ensembl:ENSP00000375872|ensembl:ENSP00000487542	psi-mi:tmm59_human(display_long)|uniprotkb:TMEM59(gene name)|psi-mi:TMEM59(display_short)|uniprotkb:C1orf8(gene name synonym)|uniprotkb:Liver membrane-bound protein(gene name synonym)|uniprotkb:HSPC001(orf name)|uniprotkb:UNQ169/PRO195(orf name)	psi-mi:a16l1_human(display_long)|uniprotkb:APG16-like 1(gene name synonym)|uniprotkb:UNQ9393/PRO34307(orf name)|uniprotkb:ATG16L1(gene name)|psi-mi:ATG16L1(display_short)|uniprotkb:APG16L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boada-Romero et al. (2013)	pubmed:23376921|imex:IM-22530	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8842018|imex:IM-22530-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291972.1|refseq:NP_001291978.1|refseq:NP_001291979.1|refseq:NP_001291980.1|refseq:NP_001291981.1|refseq:NP_001291995.1|ensembl:ENSG00000116209(gene)|ensembl:ENST00000234831(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000138"(Golgi trans cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090285"(negative regulation of protein glycosylation in Golgi)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR022065|mint:Q9BXS4|reactome:R-HSA-9013407|reactome:R-HSA-9696273|refseq:NP_004863.2	refseq:NP_001177195.1|refseq:NP_001177196.1|refseq:NP_060444.3|refseq:NP_110430.5|refseq:NP_942593.2|dip:DIP-27552N|dip:DIP-50290N|ensembl:ENSG00000085978(gene)|ensembl:ENSG00000281089(gene)|ensembl:ENST00000392017(transcript)|ensembl:ENST00000625501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0098792"(xenophagy)|go:"GO:0120095"(vacuole-isolation membrane contact site)|interpro:IPR001680(WD40 repeat)|interpro:IPR013923(Autophagy protein 16)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q676U5|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|rcsb pdb:5NUV|rcsb pdb:5ZYX|reactome:R-HSA-1632852	-	comment:mint|comment:"This interaction was decreased in the case of the 4M derivatives (Figure 6B and C), arguing that it is mediated by the identified motif. Interestingly, the 263–281 peptide fused to GST sufficed to precipitate ATG16L1 and, again, the mutated version was inactive (Figure 6D)."	-	figure legend:f6e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/04	2014/10/16	rogid:yA2dq3FVXnxw9Peh6f3UBqGzFpM9606	rogid:rLwpmIwMwd/GgPJA+7OKYTnn73E9606	intact-crc:9B0215970A087C01|rigid:5X+nhY8Z2XMUT99VsCJfwHMb0fI	false	sufficient binding region:263-281|glutathione s tranferase tag:?-?|mutation disrupting interaction:272-272,277-277,280-280,268-268	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BXS4	uniprotkb:Q676U5	intact:EBI-7054441|ensembl:ENSP00000234831|uniprotkb:Q4VBP9|uniprotkb:O75393|intact:MINT-8201752|uniprotkb:Q96KX7|uniprotkb:Q5T705|uniprotkb:B3KQL7	intact:EBI-535909|uniprotkb:Q6IPN1|uniprotkb:Q6UXW4|uniprotkb:Q6ZVZ5|uniprotkb:Q8NCY2|uniprotkb:Q96JV5|uniprotkb:Q9H619|uniprotkb:A3EXK9|uniprotkb:A3EXL0|uniprotkb:B6ZDH0|ensembl:ENSP00000375872|ensembl:ENSP00000487542	psi-mi:tmm59_human(display_long)|uniprotkb:TMEM59(gene name)|psi-mi:TMEM59(display_short)|uniprotkb:C1orf8(gene name synonym)|uniprotkb:Liver membrane-bound protein(gene name synonym)|uniprotkb:HSPC001(orf name)|uniprotkb:UNQ169/PRO195(orf name)	psi-mi:a16l1_human(display_long)|uniprotkb:APG16-like 1(gene name synonym)|uniprotkb:UNQ9393/PRO34307(orf name)|uniprotkb:ATG16L1(gene name)|psi-mi:ATG16L1(display_short)|uniprotkb:APG16L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Boada-Romero et al. (2013)	pubmed:23376921|imex:IM-22530	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8843060|imex:IM-22530-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291972.1|refseq:NP_001291978.1|refseq:NP_001291979.1|refseq:NP_001291980.1|refseq:NP_001291981.1|refseq:NP_001291995.1|ensembl:ENSG00000116209(gene)|ensembl:ENST00000234831(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000138"(Golgi trans cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090285"(negative regulation of protein glycosylation in Golgi)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR022065|mint:Q9BXS4|reactome:R-HSA-9013407|reactome:R-HSA-9696273|refseq:NP_004863.2	refseq:NP_001177195.1|refseq:NP_001177196.1|refseq:NP_060444.3|refseq:NP_110430.5|refseq:NP_942593.2|dip:DIP-27552N|dip:DIP-50290N|ensembl:ENSG00000085978(gene)|ensembl:ENSG00000281089(gene)|ensembl:ENST00000392017(transcript)|ensembl:ENST00000625501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0098792"(xenophagy)|go:"GO:0120095"(vacuole-isolation membrane contact site)|interpro:IPR001680(WD40 repeat)|interpro:IPR013923(Autophagy protein 16)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q676U5|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|rcsb pdb:5NUV|rcsb pdb:5ZYX|reactome:R-HSA-1632852	-	comment:mint|comment:"This interaction was decreased in the case of the 4M derivatives (Figure 6B and C), arguing that it is mediated by the identified motif. Interestingly, the 263–281 peptide fused to GST sufficed to precipitate ATG16L1 and, again, the mutated version was inactive (Figure 6D)."	-	figure legend:sf14d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/04	2014/10/16	rogid:yA2dq3FVXnxw9Peh6f3UBqGzFpM9606	rogid:rLwpmIwMwd/GgPJA+7OKYTnn73E9606	intact-crc:005D8AF3A28B7A08|rigid:5X+nhY8Z2XMUT99VsCJfwHMb0fI	false	glutathione s tranferase tag:?-?|sufficient binding region:263-281|mutation disrupting interaction:277-277,280-280	au1 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)