#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P78536	uniprotkb:P78504	intact:EBI-78188|intact:EBI-28987181|ensembl:ENSP00000309968|uniprotkb:O60226	intact:EBI-2847071|uniprotkb:B4DYR1|uniprotkb:E9PCF9|uniprotkb:O14902|uniprotkb:A0AV43|uniprotkb:O15122|uniprotkb:Q15816|ensembl:ENSP00000254958	psi-mi:ada17_human(display_long)|uniprotkb:ADAM17(gene name)|psi-mi:ADAM17(display_short)|uniprotkb:CSVP(gene name synonym)|uniprotkb:TACE(gene name synonym)|uniprotkb:TNF-alpha-converting enzyme(gene name synonym)|uniprotkb:TNF-alpha convertase(gene name synonym)|uniprotkb:Snake venom-like protease(gene name synonym)	psi-mi:jag1_human(display_long)|uniprotkb:JAG1(gene name)|psi-mi:JAG1(display_short)|uniprotkb:JAGL1(gene name synonym)	psi-mi:"MI:0990"(cleavage assay)	Lu et al. (2013)	pubmed:23375636|imex:IM-18664	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6512276|imex:IM-18664-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0042493"|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0033025"(regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0045121"(membrane raft)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0046872"(metal ion binding)|go:"GO:0048536"(spleen development)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0071403"(cellular response to high density lipoprotein particle stimulus)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0035624"(receptor transactivation)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR024079|interpro:IPR032029|interpro:IPR034025|interpro:IPR036436|mint:P78536|rcsb pdb:1BKC|rcsb pdb:1ZXC|rcsb pdb:2A8H|rcsb pdb:2DDF|rcsb pdb:2FV5|rcsb pdb:2FV9|rcsb pdb:2I47|rcsb pdb:2M2F|rcsb pdb:2OI0|rcsb pdb:3B92|rcsb pdb:3CKI|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|rcsb pdb:3E8R|rcsb pdb:3EDZ|rcsb pdb:3EWJ|rcsb pdb:3G42|rcsb pdb:3KMC|rcsb pdb:3KME|rcsb pdb:3L0T|rcsb pdb:3L0V|rcsb pdb:3LE9|rcsb pdb:3LEA|rcsb pdb:3LGP|rcsb pdb:3O64|reactome:R-HSA-1251985|reactome:R-HSA-1442490|reactome:R-HSA-177929|reactome:R-HSA-193692|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-5362798|ensembl:ENSG00000151694(gene)|ensembl:ENST00000310823(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002467"(germinal center formation)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0008233"(peptidase activity)|reactome:R-HSA-9662834|reactome:R-HSA-982772|reactome:R-HSA-75893|refseq:NP_003174.3|ensembl:ENSP00000309968|dip:DIP-31044N	refseq:XP_016883196.1|refseq:NP_000205.1|ensembl:ENST00000254958(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007399"(nervous system development)|ensembl:ENSG00000101384(gene)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061444"(endocardial cushion cell development)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0072006"(nephron development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072017"(distal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|go:"GO:0008083"(growth factor activity)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR026219|interpro:IPR033108|rcsb pdb:2KB9|rcsb pdb:2VJ2|rcsb pdb:4CBZ|rcsb pdb:4CC0|rcsb pdb:4CC1|rcsb pdb:4XI7|rcsb pdb:5BO1|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-8941856|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9013507|reactome:R-HSA-9013700|interpro:IPR001881(EGF-like calcium-binding)|dip:DIP-46371N	-	-	-	figure legend:6C|antagonist:TAPI-2, an inhibitor of ADAM17|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/02/12	2014/10/16	rogid:9ZXiwccqzkHXJUHY1KNhH/ZGG+89606	rogid:kaBPZjsO7mchlR6vYIknqvTluos9606	intact-crc:04AF01BFA416EBC2|rigid:RULPceEgFzxQzRwmIZCeYn9bdqM	false	sufficient binding region:215-671	sufficient binding region:1047-1061	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)