#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:28304"	uniprotkb:Q91V88	intact:EBI-1379423	intact:EBI-6895007|uniprotkb:Q6NV58|uniprotkb:Q80VP6|uniprotkb:Q91XL5|uniprotkb:Q91ZD3|uniprotkb:Q923T5|ensembl:ENSMUSP00000040684	psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long)	psi-mi:npnt_mouse(display_long)|uniprotkb:Npnt(gene name)|psi-mi:Npnt(display_short)|uniprotkb:Neph1(gene name synonym)|uniprotkb:Poem(gene name synonym)|uniprotkb:Preosteoblast EGF-like repeat protein with MAM domain(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Sato et al. (2013)	pubmed:23357641|imex:IM-20972	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6895005|imex:IM-20972-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0045184"(establishment of protein localization)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097195"(pilomotor reflex)|go:"GO:2000721"(positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|ensembl:ENSMUSG00000040998(gene)|ensembl:ENSMUST00000042744(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030485"(smooth muscle contractile fiber)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|refseq:NP_001274030.1|refseq:NP_001274031.1|refseq:NP_001025007.1|refseq:NP_277060.2	-	-	-	figure legend:1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/16	2014/10/16	-	rogid:Uxkj2FaIldZeAJSuA45KSAu7RiY10090	intact-crc:44F6878E85796BC7	false	tag:?-?	flag tag:c-c|necessary binding region:420-561	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
chebi:"CHEBI:28815"	uniprotkb:Q91V88	intact:EBI-2566501	intact:EBI-6895007|uniprotkb:Q6NV58|uniprotkb:Q80VP6|uniprotkb:Q91XL5|uniprotkb:Q91ZD3|uniprotkb:Q923T5|ensembl:ENSMUSP00000040684	psi-mi:heparan_sulfate(display_short)|psi-mi:"CHEBI:28815"(display_long)	psi-mi:npnt_mouse(display_long)|uniprotkb:Npnt(gene name)|psi-mi:Npnt(display_short)|uniprotkb:Neph1(gene name synonym)|uniprotkb:Poem(gene name synonym)|uniprotkb:Preosteoblast EGF-like repeat protein with MAM domain(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Sato et al. (2013)	pubmed:23357641|imex:IM-20972	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6895079|imex:IM-20972-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	matrixdb:GAG_2(source reference)	go:"GO:0045184"(establishment of protein localization)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097195"(pilomotor reflex)|go:"GO:2000721"(positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|ensembl:ENSMUSG00000040998(gene)|ensembl:ENSMUST00000042744(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030485"(smooth muscle contractile fiber)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|refseq:NP_001274030.1|refseq:NP_001274031.1|refseq:NP_001025007.1|refseq:NP_277060.2	-	-	-	figure legend:1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/16	2014/10/16	-	rogid:Uxkj2FaIldZeAJSuA45KSAu7RiY10090	intact-crc:8722EA46703ACD0E	false	tag:?-?	flag tag:c-c|necessary binding region:420-561	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
chebi:"CHEBI:52562"	uniprotkb:Q91V88	intact:EBI-6895140	intact:EBI-6895007|uniprotkb:Q6NV58|uniprotkb:Q80VP6|uniprotkb:Q91XL5|uniprotkb:Q91ZD3|uniprotkb:Q923T5|ensembl:ENSMUSP00000040684	psi-mi:chondroitin sulfate e(display_short)|psi-mi:"CHEBI:52562"(display_long)	psi-mi:npnt_mouse(display_long)|uniprotkb:Npnt(gene name)|psi-mi:Npnt(display_short)|uniprotkb:Neph1(gene name synonym)|uniprotkb:Poem(gene name synonym)|uniprotkb:Preosteoblast EGF-like repeat protein with MAM domain(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Sato et al. (2013)	pubmed:23357641|imex:IM-20972	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6895142|imex:IM-20972-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0045184"(establishment of protein localization)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097195"(pilomotor reflex)|go:"GO:2000721"(positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|ensembl:ENSMUSG00000040998(gene)|ensembl:ENSMUST00000042744(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030485"(smooth muscle contractile fiber)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|refseq:NP_001274030.1|refseq:NP_001274031.1|refseq:NP_001025007.1|refseq:NP_277060.2	-	-	-	figure legend:1|comment:"When incubated with CS-E in the presence of EDTA, both nephronectin and MAM exhibited significant reductions in their binding activities to CS-E, resulting in 30-40% loss of the activities compared with those in the presence of 1 mM Ca2+ (Fig. 2A)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/16	2020/12/29	-	rogid:Uxkj2FaIldZeAJSuA45KSAu7RiY10090	intact-crc:15B258DCCF792531	false	tag:?-?	sufficient binding region:88-254|flag tag:c-c	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q91V88	uniprotkb:O00468	intact:EBI-6895007|uniprotkb:Q6NV58|uniprotkb:Q80VP6|uniprotkb:Q91XL5|uniprotkb:Q91ZD3|uniprotkb:Q923T5|ensembl:ENSMUSP00000040684	intact:EBI-947482|uniprotkb:Q5SVA2|uniprotkb:Q60FE1|uniprotkb:Q7KYS8|uniprotkb:Q8N4J5|uniprotkb:Q96IC1|uniprotkb:Q9BTD4|uniprotkb:Q5SVA1	psi-mi:npnt_mouse(display_long)|uniprotkb:Npnt(gene name)|psi-mi:Npnt(display_short)|uniprotkb:Neph1(gene name synonym)|uniprotkb:Poem(gene name synonym)|uniprotkb:Preosteoblast EGF-like repeat protein with MAM domain(gene name synonym)	psi-mi:agrin_human(display_long)|uniprotkb:AGRN(gene name)|psi-mi:AGRN(display_short)|uniprotkb:AGRIN(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Sato et al. (2013)	pubmed:23357641|imex:IM-20972	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6895248|imex:IM-20972-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0045184"(establishment of protein localization)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097195"(pilomotor reflex)|go:"GO:2000721"(positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|ensembl:ENSMUSG00000040998(gene)|ensembl:ENSMUST00000042744(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030485"(smooth muscle contractile fiber)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|refseq:NP_001274030.1|refseq:NP_001274031.1|refseq:NP_001025007.1|refseq:NP_277060.2	refseq:NP_940978.2|interpro:IPR004850(Agrin NtA)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR000082(SEA)|interpro:IPR008993(TIMP-like, OB-fold)|refseq:XP_005244806.1|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003884(Factor I membrane attack complex)|mint:O00468|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043236"(laminin binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0045202"(synapse)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050808"(synapse organization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-216083|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-419037|reactome:R-HSA-4420332|reactome:R-HSA-975634|interpro:IPR036058|interpro:IPR036364|refseq:NP_001292204.1	-	-	-	figure legend:3, 4|comment:"The binding activities of nephronectin to agrin were severely impaired when the HS chains were removed by treatment with heparitinase (Fig. 3C). The binding was also inhibited by addition of an excess amount of heparin (Fig. 3C), corroborating the requirement of the HS chains for the interactions of nephronectin with agrin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/16	2018/09/18	rogid:Uxkj2FaIldZeAJSuA45KSAu7RiY10090	rogid:LRk4v4aYLk5kep9EIbjjiCGM7OM9606	intact-crc:F52298B8BF083177|rigid:RHGNSEoKwqSSmyO4P2H6zNj9qDw	false	mutation decreasing interaction:445-445|mutation decreasing interaction:502-502,503-503,504-504|mutation decreasing interaction:528-528|mutation decreasing interaction:541-541,542-542,543-543|flag tag:c-c|mutation decreasing interaction:557-557,558-558,559-559,560-560|mutation decreasing interaction:459-459,464-464|mutation decreasing interaction:471-471|necessary binding region:420-561	his tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q91V88	uniprotkb:P98160	intact:EBI-6895007|uniprotkb:Q6NV58|uniprotkb:Q80VP6|uniprotkb:Q91XL5|uniprotkb:Q91ZD3|uniprotkb:Q923T5|ensembl:ENSMUSP00000040684	intact:EBI-947664|uniprotkb:Q16287|uniprotkb:Q9H3V5|uniprotkb:Q5SZI3|ensembl:ENSP00000363827	psi-mi:npnt_mouse(display_long)|uniprotkb:Npnt(gene name)|psi-mi:Npnt(display_short)|uniprotkb:Neph1(gene name synonym)|uniprotkb:Poem(gene name synonym)|uniprotkb:Preosteoblast EGF-like repeat protein with MAM domain(gene name synonym)	psi-mi:pgbm_human(display_long)|uniprotkb:Perlecan(gene name synonym)|uniprotkb:HSPG2(gene name)|psi-mi:HSPG2(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Sato et al. (2013)	pubmed:23357641|imex:IM-20972	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-6895274|imex:IM-20972-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0045184"(establishment of protein localization)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097195"(pilomotor reflex)|go:"GO:2000721"(positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|ensembl:ENSMUSG00000040998(gene)|ensembl:ENSMUST00000042744(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030485"(smooth muscle contractile fiber)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|refseq:NP_001274030.1|refseq:NP_001274031.1|refseq:NP_001025007.1|refseq:NP_277060.2	refseq:NP_001278789.1|refseq:NP_005520.4|ensembl:ENSG00000142798(gene)|ensembl:ENST00000374695(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0030154"(cell differentiation)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072359"(circulatory system development)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR000034(Laminin B)|interpro:IPR000082(SEA)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR023415|interpro:IPR036055|interpro:IPR036179|mint:P98160|rcsb pdb:3SH4|rcsb pdb:3SH5|reactome:R-HSA-1474228|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-975634|reactome:R-HSA-977225	-	-	-	figure legend:3|comment:"The binding activities of nephronectin to perlecan were severely impaired when the HS chains were removed by treatment with heparitinase (Fig. 3C). The binding was also inhibited by addition of an excess amount of heparin (Fig. 3C), corroborating the requirement of the HS chains for the interactions of nephronectin with perlecan."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/16	2014/10/16	rogid:Uxkj2FaIldZeAJSuA45KSAu7RiY10090	rogid:5ctWru2Fde+1Twjd9B7u24hsIKY9606	intact-crc:626199683E66059F|rigid:gR6OjomGbVMw4VTTwnv3TQuX45g	false	necessary binding region:420-561|flag tag:c-c	his tag:c-c	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)