#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P42684 uniprotkb:O95866 intact:EBI-1102694|uniprotkb:Q5T0X6|uniprotkb:Q5W0C5|uniprotkb:B7UEF2|uniprotkb:B7UEF3|uniprotkb:B7UEF4|uniprotkb:B7UEF5|uniprotkb:Q6NZY6|uniprotkb:Q7Z301|ensembl:ENSP00000427562|uniprotkb:A0M8X0 intact:EBI-6857938|uniprotkb:A2BEZ1|uniprotkb:A2BEZ2|uniprotkb:A2BEZ3|uniprotkb:A2BEZ4|uniprotkb:A2BEZ5|uniprotkb:B0UXC4|uniprotkb:B0UXC7|uniprotkb:B0UXC8|uniprotkb:B0V024|uniprotkb:B0V026|uniprotkb:Q14CK2|uniprotkb:Q96A86|uniprotkb:Q96A87|uniprotkb:Q96A88|uniprotkb:Q96A89|uniprotkb:Q96A90|uniprotkb:Q96A91|ensembl:ENSP00000382944|ensembl:ENSP00000391097|ensembl:ENSP00000406706|ensembl:ENSP00000408430|ensembl:ENSP00000416447|ensembl:ENSP00000497720 psi-mi:abl2_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym) psi-mi:g6b_human(display_long)|uniprotkb:MPIG6B(gene name)|psi-mi:MPIG6B(display_short)|uniprotkb:C6orf25(gene name synonym)|uniprotkb:G6B(gene name synonym)|uniprotkb:G6B-B(gene name synonym)|uniprotkb:Protein G6b(gene name synonym) psi-mi:"MI:0096"(pull down) Schweigel et al. (2013) pubmed:23322602|imex:IM-20819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6691658|imex:IM-20819-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000143322(gene)|ensembl:ENST00000502732(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035640"(exploration behavior)|go:"GO:0051015"(actin filament binding)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P42684|rcsb pdb:2ECD|rcsb pdb:2KK1|rcsb pdb:2XYN|rcsb pdb:3GVU|rcsb pdb:3HMI|rcsb pdb:3ULR|rcsb pdb:4EIH|rcsb pdb:5NP3|rcsb pdb:5NP5|reactome:R-HSA-428890|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9706369|refseq:NP_001129472.1|refseq:NP_001129473.1|refseq:NP_001161708.1|refseq:NP_001161709.1|refseq:NP_001161710.1|refseq:NP_001161711.1|refseq:NP_005149.4|refseq:NP_009298.1|refseq:XP_005245145.1|dip:DIP-91N refseq:NP_079536.2|refseq:NP_612116.1|refseq:NP_612117.1|refseq:NP_612118.1|refseq:NP_612119.1|refseq:NP_612121.1|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0035855"(megakaryocyte development)|interpro:IPR028070|rcsb pdb:6R0X|reactome:R-HSA-114604|ensembl:ENSG00000204420|ensembl:ENSG00000204420|ensembl:ENSG00000206396|ensembl:ENSG00000231003|ensembl:ENSG00000224393|ensembl:ENSG00000237459|ensembl:ENSG00000230060|ensembl:ENSG00000204420(gene)|ensembl:ENSG00000206396(gene)|ensembl:ENSG00000224393(gene)|ensembl:ENSG00000230060(gene)|ensembl:ENSG00000231003(gene)|ensembl:ENSG00000237459(gene)|ensembl:ENST00000400071(transcript)|ensembl:ENST00000415728(transcript)|ensembl:ENST00000436030(transcript)|ensembl:ENST00000447587(transcript)|ensembl:ENST00000457884(transcript)|ensembl:ENST00000649779(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane) - crc64:ED93869BC2B14FAA - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/05/24 2018/04/06 rogid:ct5SG4m0wewDSllBklIOi48BV7Q9606 rogid:ssBED/yclDbUj7nygYaY9Gn8xFU9606 intact-crc:C469631D6B8FAB28|rigid:OhEqHKgZTtwdd9Esm2b6L55YbCQ false mutation disrupting interaction:198-198|biotin tag:?-?|sufficient binding region:163-273(IPR000980)|glutathione s tranferase tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P42684 uniprotkb:Q99952 intact:EBI-1102694|uniprotkb:Q5T0X6|uniprotkb:Q5W0C5|uniprotkb:B7UEF2|uniprotkb:B7UEF3|uniprotkb:B7UEF4|uniprotkb:B7UEF5|uniprotkb:Q6NZY6|uniprotkb:Q7Z301|ensembl:ENSP00000427562|uniprotkb:A0M8X0 intact:EBI-1384210|uniprotkb:Q53P42|intact:EBI-3959579|uniprotkb:B4E1E6|ensembl:ENSP00000175756 psi-mi:abl2_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym) psi-mi:ptn18_human(display_long)|uniprotkb:Brain-derived phosphatase(gene name synonym)|uniprotkb:PTPN18(gene name)|psi-mi:PTPN18(display_short)|uniprotkb:BDP1(gene name synonym) psi-mi:"MI:0096"(pull down) Schweigel et al. (2013) pubmed:23322602|imex:IM-20819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6691658|imex:IM-20819-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000143322(gene)|ensembl:ENST00000502732(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035640"(exploration behavior)|go:"GO:0051015"(actin filament binding)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P42684|rcsb pdb:2ECD|rcsb pdb:2KK1|rcsb pdb:2XYN|rcsb pdb:3GVU|rcsb pdb:3HMI|rcsb pdb:3ULR|rcsb pdb:4EIH|rcsb pdb:5NP3|rcsb pdb:5NP5|reactome:R-HSA-428890|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9706369|refseq:NP_001129472.1|refseq:NP_001129473.1|refseq:NP_001161708.1|refseq:NP_001161709.1|refseq:NP_001161710.1|refseq:NP_001161711.1|refseq:NP_005149.4|refseq:NP_009298.1|refseq:XP_005245145.1|dip:DIP-91N refseq:NP_055184.2|refseq:NP_001135842.1|ensembl:ENSG00000072135(gene)|ensembl:ENST00000175756(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:1901185"(negative regulation of ERBB signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:Q99952|rcsb pdb:2OC3|rcsb pdb:4GFU|rcsb pdb:4GFV|rcsb pdb:4NND|reactome:R-HSA-8863795|reactome:R-HSA-9008059 - crc64:ED93869BC2B14FAA - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/05/24 2018/04/06 rogid:ct5SG4m0wewDSllBklIOi48BV7Q9606 rogid:xRrifp9kOwi0SLtlIFtSjiv4qN89606 intact-crc:C469631D6B8FAB28|rigid:OhEqHKgZTtwdd9Esm2b6L55YbCQ false mutation disrupting interaction:198-198|biotin tag:?-?|sufficient binding region:163-273(IPR000980)|glutathione s tranferase tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P42684 uniprotkb:P16284 intact:EBI-1102694|uniprotkb:Q5T0X6|uniprotkb:Q5W0C5|uniprotkb:B7UEF2|uniprotkb:B7UEF3|uniprotkb:B7UEF4|uniprotkb:B7UEF5|uniprotkb:Q6NZY6|uniprotkb:Q7Z301|ensembl:ENSP00000427562|uniprotkb:A0M8X0 intact:EBI-716404|uniprotkb:Q6LDA9|uniprotkb:Q8TBH1|uniprotkb:Q96RF5|uniprotkb:Q96RF6|uniprotkb:Q9NP65|uniprotkb:Q9NPB7|uniprotkb:Q9NPG9|uniprotkb:Q9NQS9|uniprotkb:Q9NQT0|uniprotkb:Q9NQT1|uniprotkb:Q9NQT2|ensembl:ENSP00000457421|uniprotkb:A8K3S7|uniprotkb:D3DU31|uniprotkb:A0A075B738 psi-mi:abl2_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym) psi-mi:peca1_human(display_long)|uniprotkb:PECA1(gene name synonym)|uniprotkb:EndoCAM(gene name synonym)|uniprotkb:GPIIA'(gene name synonym)|uniprotkb:PECAM1(gene name)|psi-mi:PECAM1(display_short) psi-mi:"MI:0096"(pull down) Schweigel et al. (2013) pubmed:23322602|imex:IM-20819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6691658|imex:IM-20819-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000143322(gene)|ensembl:ENST00000502732(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035640"(exploration behavior)|go:"GO:0051015"(actin filament binding)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P42684|rcsb pdb:2ECD|rcsb pdb:2KK1|rcsb pdb:2XYN|rcsb pdb:3GVU|rcsb pdb:3HMI|rcsb pdb:3ULR|rcsb pdb:4EIH|rcsb pdb:5NP3|rcsb pdb:5NP5|reactome:R-HSA-428890|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9706369|refseq:NP_001129472.1|refseq:NP_001129473.1|refseq:NP_001161708.1|refseq:NP_001161709.1|refseq:NP_001161710.1|refseq:NP_001161711.1|refseq:NP_005149.4|refseq:NP_009298.1|refseq:XP_005245145.1|dip:DIP-91N refseq:NP_000433.4|ensembl:ENSG00000261371(gene)|ensembl:ENST00000563924(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008037"(cell recognition)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035696"(monocyte extravasation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050904"(diapedesis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072011"(glomerular endothelium development)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0150107"(positive regulation of protein localization to cell-cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040878|rcsb pdb:2KY5|rcsb pdb:5C14|rcsb pdb:5GNI|reactome:R-HSA-114608|reactome:R-HSA-202733|reactome:R-HSA-210990|reactome:R-HSA-216083|reactome:R-HSA-432142|reactome:R-HSA-6798695|refseq:XP_005276937.1|refseq:XP_005276938.1|refseq:XP_005276939.1|refseq:XP_011523191.1|refseq:XP_011523192.1|refseq:XP_016880227.1|refseq:XP_016880228.1|refseq:XP_016880229.1 - crc64:ED93869BC2B14FAA - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/05/24 2018/04/06 rogid:ct5SG4m0wewDSllBklIOi48BV7Q9606 rogid:Rno8MNcOwnEuSww3HPKwGZQQjXc9606 intact-crc:C469631D6B8FAB28|rigid:OhEqHKgZTtwdd9Esm2b6L55YbCQ false mutation disrupting interaction:198-198|biotin tag:?-?|sufficient binding region:163-273(IPR000980)|glutathione s tranferase tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P42684 uniprotkb:Q9NQ75 intact:EBI-1102694|uniprotkb:Q5T0X6|uniprotkb:Q5W0C5|uniprotkb:B7UEF2|uniprotkb:B7UEF3|uniprotkb:B7UEF4|uniprotkb:B7UEF5|uniprotkb:Q6NZY6|uniprotkb:Q7Z301|ensembl:ENSP00000427562|uniprotkb:A0M8X0 intact:EBI-2609710|uniprotkb:E1P5Z8|uniprotkb:Q9BYL5|uniprotkb:Q96K09|uniprotkb:Q5QPD6|ensembl:ENSP00000353462|ensembl:ENSP00000506506 psi-mi:abl2_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym) psi-mi:cass4_human(display_long)|uniprotkb:CASS4(gene name)|psi-mi:CASS4(display_short)|uniprotkb:C20orf32(gene name synonym)|uniprotkb:HEFL(gene name synonym)|uniprotkb:HEF1-EFS-p130Cas-like protein(gene name synonym)|uniprotkb:HEF-like protein(gene name synonym) psi-mi:"MI:0096"(pull down) Schweigel et al. (2013) pubmed:23322602|imex:IM-20819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6691658|imex:IM-20819-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000143322(gene)|ensembl:ENST00000502732(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035640"(exploration behavior)|go:"GO:0051015"(actin filament binding)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P42684|rcsb pdb:2ECD|rcsb pdb:2KK1|rcsb pdb:2XYN|rcsb pdb:3GVU|rcsb pdb:3HMI|rcsb pdb:3ULR|rcsb pdb:4EIH|rcsb pdb:5NP3|rcsb pdb:5NP5|reactome:R-HSA-428890|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9706369|refseq:NP_001129472.1|refseq:NP_001129473.1|refseq:NP_001161708.1|refseq:NP_001161709.1|refseq:NP_001161710.1|refseq:NP_001161711.1|refseq:NP_005149.4|refseq:NP_009298.1|refseq:XP_005245145.1|dip:DIP-91N refseq:NP_001157586.1|refseq:NP_001157587.1|refseq:NP_001157588.1|refseq:NP_065089.2|ensembl:ENSG00000087589(gene)|ensembl:ENST00000360314(transcript)|ensembl:ENST00000679887(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR035512|interpro:IPR035744|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|rcsb pdb:2CRE|go:"GO:0007155"(cell adhesion) - crc64:ED93869BC2B14FAA - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/05/24 2018/04/06 rogid:ct5SG4m0wewDSllBklIOi48BV7Q9606 rogid:Yb30/8ckx3M9hMD8/nVhleJ9J9c9606 intact-crc:C469631D6B8FAB28|rigid:OhEqHKgZTtwdd9Esm2b6L55YbCQ false mutation disrupting interaction:198-198|biotin tag:?-?|sufficient binding region:163-273(IPR000980)|glutathione s tranferase tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P42684 uniprotkb:Q9UIB8 intact:EBI-1102694|uniprotkb:Q5T0X6|uniprotkb:Q5W0C5|uniprotkb:B7UEF2|uniprotkb:B7UEF3|uniprotkb:B7UEF4|uniprotkb:B7UEF5|uniprotkb:Q6NZY6|uniprotkb:Q7Z301|ensembl:ENSP00000427562|uniprotkb:A0M8X0 intact:EBI-6691679|ensembl:ENSP00000312367|uniprotkb:B2R8T1|uniprotkb:B7Z3R8|uniprotkb:O15430|uniprotkb:O95266|uniprotkb:O95660|uniprotkb:Q5H9R1|uniprotkb:Q6FHA8|uniprotkb:Q8WLP1|uniprotkb:Q8WWI8|uniprotkb:Q9UF04|uniprotkb:Q9UIB6|uniprotkb:Q9UIB7|uniprotkb:Q9UIT7 psi-mi:abl2_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym) psi-mi:slaf5_human(display_long)|uniprotkb:CD84(gene name)|psi-mi:CD84(display_short)|uniprotkb:SLAMF5(gene name synonym)|uniprotkb:Cell surface antigen MAX.3(gene name synonym)|uniprotkb:Hly9-beta(gene name synonym)|uniprotkb:Leukocyte differentiation antigen CD84(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule 5(gene name synonym) psi-mi:"MI:0096"(pull down) Schweigel et al. (2013) pubmed:23322602|imex:IM-20819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6691658|imex:IM-20819-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000143322(gene)|ensembl:ENST00000502732(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035640"(exploration behavior)|go:"GO:0051015"(actin filament binding)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P42684|rcsb pdb:2ECD|rcsb pdb:2KK1|rcsb pdb:2XYN|rcsb pdb:3GVU|rcsb pdb:3HMI|rcsb pdb:3ULR|rcsb pdb:4EIH|rcsb pdb:5NP3|rcsb pdb:5NP5|reactome:R-HSA-428890|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9706369|refseq:NP_001129472.1|refseq:NP_001129473.1|refseq:NP_001161708.1|refseq:NP_001161709.1|refseq:NP_001161710.1|refseq:NP_001161711.1|refseq:NP_005149.4|refseq:NP_009298.1|refseq:XP_005245145.1|dip:DIP-91N refseq:NP_001317671.1|ensembl:ENSG00000066294(gene)|ensembl:ENST00000311224(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0006952"(defense response)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0032685"(negative regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032701"(negative regulation of interleukin-18 production)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043305"(negative regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2PKD|reactome:R-HSA-202733|interpro:IPR003599(Immunoglobulin subtype)|refseq:NP_001171808.1|refseq:NP_001171810.1|refseq:NP_001171811.1|refseq:NP_003865.1|ensembl:ENSG00000066294|ensembl:ENSG00000066294|ensembl:ENSG00000066294|dip:DIP-60957N - crc64:ED93869BC2B14FAA - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/05/24 2018/04/06 rogid:ct5SG4m0wewDSllBklIOi48BV7Q9606 rogid:i4o7JgNmjLKaueK1cKJJllrEERg9606 intact-crc:C469631D6B8FAB28|rigid:OhEqHKgZTtwdd9Esm2b6L55YbCQ false mutation disrupting interaction:198-198|biotin tag:?-?|sufficient binding region:163-273(IPR000980)|glutathione s tranferase tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05141 uniprotkb:O43639 intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671 intact:EBI-713635|uniprotkb:Q9BWN9|uniprotkb:Q9UIC3|ensembl:ENSP00000233154|ensembl:ENSP00000377018|uniprotkb:D3DVK1 psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym) psi-mi:nck2_human(display_long)|uniprotkb:NCK adaptor protein 2(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-beta(gene name synonym)|uniprotkb:NCK2(gene name)|psi-mi:NCK2(display_short)|uniprotkb:GRB4(gene name synonym)|uniprotkb:Growth factor receptor-bound protein 4(gene name synonym) psi-mi:"MI:0096"(pull down) Schweigel et al. (2013) pubmed:23322602|imex:IM-20819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6691770|imex:IM-20819-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N refseq:XP_006712860.1|refseq:NP_001004720.1|refseq:NP_003572.2|ensembl:ENSG00000071051(gene)|ensembl:ENST00000233154(transcript)|ensembl:ENST00000393349(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0060996"(dendritic spine development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028524|interpro:IPR035559|interpro:IPR035560|interpro:IPR035561|interpro:IPR035883|interpro:IPR036028|interpro:IPR036860|mint:O43639|rcsb pdb:1U5S|rcsb pdb:1WX6|rcsb pdb:1Z3K|rcsb pdb:2B86|rcsb pdb:2CIA|rcsb pdb:2FRW|rcsb pdb:2FRY|rcsb pdb:2JXB|rcsb pdb:4E6R|reactome:R-HSA-186763|reactome:R-HSA-373753|reactome:R-HSA-3928664|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-8985801|reactome:R-HSA-9013420|reactome:R-HSA-9013424|refseq:XP_016860592.1|refseq:XP_016860593.1|refseq:XP_016860594.1|refseq:XP_011510293.1 - - - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/05/24 2014/10/16 rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606 rogid:WV9nJ78Im/ga5KQlRuSN2ODzWpQ9606 intact-crc:068AA3A7653DF672|rigid:etKXjOPz8QgoCDvOnMp5UrAXai8 false - sufficient binding region:275-380(IPR000980)|biotin tag:?-?|glutathione s tranferase tag:?-?|mutation disrupting interaction:311-311|mutation:296-296 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14796 uniprotkb:O43294 intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906 intact:EBI-1051449|uniprotkb:Q9BPW3|uniprotkb:Q9Y2V5|uniprotkb:B2R8D5|ensembl:ENSP00000378332 psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym) psi-mi:tgfi1_human(display_long)|uniprotkb:TGFB1I1(gene name)|psi-mi:TGFB1I1(display_short)|uniprotkb:ARA55(gene name synonym)|uniprotkb:Hydrogen peroxide-inducible clone 5 protein(gene name synonym)|uniprotkb:Androgen receptor-associated protein of 55 kDa(gene name synonym)|uniprotkb:Androgen receptor coactivator 55 kDa protein(gene name synonym) psi-mi:"MI:0096"(pull down) Schweigel et al. (2013) pubmed:23322602|imex:IM-20819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6691752|imex:IM-20819-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933 refseq:NP_001035919.1|refseq:NP_001158191.1|refseq:NP_057011.2|ensembl:ENSP00000355117|ensembl:ENST00000394858|ensembl:ENSP00000378327|ensembl:ENSP00000378332|ensembl:ENST00000567607|ensembl:ENSP00000457586|ensembl:ENST00000361773|ensembl:ENSG00000140682(gene)|ensembl:ENST00000394863(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048495"(Roundabout binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0070411"(I-SMAD binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR017305(Leupaxin)|mint:O43294|dip:DIP-5931N - - - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/05/24 2018/04/06 rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606 rogid:ekkGbwdFenBhBn0HzJjd4Szi61U9606 intact-crc:9599EAA803A5203E|rigid:+dEbJff6dc0D7M/cPh5DVyOwuts false mutation disrupting interaction:31-31|glutathione s tranferase tag:?-?|biotin tag:?-?|sufficient binding region:1-106(IPR000980) - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14796 uniprotkb:Q92835 intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906 intact:EBI-1380477|uniprotkb:O00145|uniprotkb:Q13544|uniprotkb:Q13545|uniprotkb:Q6P5A4|uniprotkb:Q92656|uniprotkb:Q9UE80|ensembl:ENSP00000405338|ensembl:ENSP00000487191 psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym) psi-mi:ship1_human(display_long)|uniprotkb:INPP5D(gene name)|psi-mi:INPP5D(display_short)|uniprotkb:SHIP(gene name synonym)|uniprotkb:SHIP1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 5-phosphatase(gene name synonym) psi-mi:"MI:0096"(pull down) Schweigel et al. (2013) pubmed:23322602|imex:IM-20819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6691752|imex:IM-20819-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933 refseq:NP_001017915.1|refseq:NP_005532.2|ensembl:ENST00000359570|ensembl:ENSP00000352575|ensembl:ENSP00000405338|ensembl:ENST00000629761|ensembl:ENSP00000486669|ensembl:ENSP00000487191|ensembl:ENSG00000168918(gene)|ensembl:ENSG00000281614(gene)|ensembl:ENST00000445964(transcript)|ensembl:ENST00000630854(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|mint:Q92835|rcsb pdb:2YSX|rcsb pdb:5RW2|rcsb pdb:5RW3|rcsb pdb:5RW4|rcsb pdb:5RW5|rcsb pdb:5RW6|rcsb pdb:5RW7|rcsb pdb:5RW8|rcsb pdb:5RW9|rcsb pdb:5RWA|rcsb pdb:5RWB|rcsb pdb:5RWC|rcsb pdb:5RWD|rcsb pdb:5RWE|rcsb pdb:5RWF|rcsb pdb:5RWG|rcsb pdb:5RWH|rcsb pdb:5RWI|rcsb pdb:5RWJ|rcsb pdb:5RWK|rcsb pdb:5RWL|rcsb pdb:5RWM|rcsb pdb:5RWN|rcsb pdb:5RWO|rcsb pdb:5RWP|rcsb pdb:5RWQ|rcsb pdb:5RWR|rcsb pdb:5RWS|rcsb pdb:5RWT|rcsb pdb:5RWU|rcsb pdb:5RWV|rcsb pdb:5RWW|rcsb pdb:5RWX|rcsb pdb:5RWY|rcsb pdb:5RWZ|rcsb pdb:5RX0|rcsb pdb:5RX1|rcsb pdb:5RX2|rcsb pdb:5RX3|rcsb pdb:5RX4|rcsb pdb:5RX5|rcsb pdb:5RX6|rcsb pdb:5RX7|rcsb pdb:5RX8|rcsb pdb:5RX9|rcsb pdb:5RXA|rcsb pdb:5RXB|rcsb pdb:5RXC|rcsb pdb:5RXD|rcsb pdb:5RXE|rcsb pdb:5RXF|rcsb pdb:5RXG|rcsb pdb:5RXH|rcsb pdb:5RXI|rcsb pdb:5RXJ|rcsb pdb:5RXK|rcsb pdb:5RXL|rcsb pdb:5RXM|rcsb pdb:5RXO|rcsb pdb:5RXP|rcsb pdb:5RXQ|rcsb pdb:5RXR|rcsb pdb:5RXS|rcsb pdb:5RXT|rcsb pdb:5RXU|rcsb pdb:5RXV|rcsb pdb:5RXW|rcsb pdb:5RXX|rcsb pdb:5RXY|rcsb pdb:5RXZ|rcsb pdb:5RY0|rcsb pdb:5RY1|rcsb pdb:5RY2|rcsb pdb:5RY3|rcsb pdb:5RY4|rcsb pdb:5RY5|rcsb pdb:5RY6|rcsb pdb:5RY7|rcsb pdb:5RY8|rcsb pdb:5RY9|rcsb pdb:5RYA|rcsb pdb:5RYB|rcsb pdb:5RYC|rcsb pdb:5RYD|rcsb pdb:5RYE|rcsb pdb:5RYF|rcsb pdb:5RYG|rcsb pdb:5RYH|rcsb pdb:5RYI|rcsb pdb:5RYJ|rcsb pdb:5RYK|rcsb pdb:5RYL|rcsb pdb:6IBD|rcsb pdb:6XY7|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-202424|reactome:R-HSA-210990|reactome:R-HSA-912526 - - - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/05/24 2018/04/06 rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606 rogid:lM4QLD8DUZmagYuz8qoKAZqjJOI9606 intact-crc:9599EAA803A5203E|rigid:+dEbJff6dc0D7M/cPh5DVyOwuts false mutation disrupting interaction:31-31|glutathione s tranferase tag:?-?|biotin tag:?-?|sufficient binding region:1-106(IPR000980) - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14796 uniprotkb:Q9UN19 intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906 intact:EBI-3918199|uniprotkb:Q9UHF2|uniprotkb:Q8TCK5|ensembl:ENSP00000423602 psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym) psi-mi:dapp1_human(display_long)|uniprotkb:DAPP1(gene name)|psi-mi:DAPP1(display_short)|uniprotkb:BAM32(gene name synonym)|uniprotkb:B lymphocyte adapter protein Bam32(gene name synonym)|uniprotkb:B-cell adapter molecule of 32 kDa(gene name synonym)|uniprotkb:HSPC066(orf name) psi-mi:"MI:0096"(pull down) Schweigel et al. (2013) pubmed:23322602|imex:IM-20819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6691752|imex:IM-20819-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933 refseq:NP_001293080.1|refseq:NP_055210.2|ensembl:ENSG00000070190(gene)|ensembl:ENST00000512369(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035843|interpro:IPR036860|mint:Q9UN19|rcsb pdb:1FAO|rcsb pdb:1FB8|reactome:R-HSA-983695 - - - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/05/24 2018/04/06 rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606 rogid:YYI49xKbndaB1MfL/QEovp2BF009606 intact-crc:9599EAA803A5203E|rigid:+dEbJff6dc0D7M/cPh5DVyOwuts false mutation disrupting interaction:31-31|glutathione s tranferase tag:?-?|biotin tag:?-?|sufficient binding region:1-106(IPR000980) - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14796 uniprotkb:P16284 intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906 intact:EBI-716404|uniprotkb:Q6LDA9|uniprotkb:Q8TBH1|uniprotkb:Q96RF5|uniprotkb:Q96RF6|uniprotkb:Q9NP65|uniprotkb:Q9NPB7|uniprotkb:Q9NPG9|uniprotkb:Q9NQS9|uniprotkb:Q9NQT0|uniprotkb:Q9NQT1|uniprotkb:Q9NQT2|ensembl:ENSP00000457421|uniprotkb:A8K3S7|uniprotkb:D3DU31|uniprotkb:A0A075B738 psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym) psi-mi:peca1_human(display_long)|uniprotkb:PECA1(gene name synonym)|uniprotkb:EndoCAM(gene name synonym)|uniprotkb:GPIIA'(gene name synonym)|uniprotkb:PECAM1(gene name)|psi-mi:PECAM1(display_short) psi-mi:"MI:0096"(pull down) Schweigel et al. (2013) pubmed:23322602|imex:IM-20819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6691752|imex:IM-20819-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933 refseq:NP_000433.4|ensembl:ENSG00000261371(gene)|ensembl:ENST00000563924(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008037"(cell recognition)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035696"(monocyte extravasation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050904"(diapedesis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072011"(glomerular endothelium development)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0150107"(positive regulation of protein localization to cell-cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040878|rcsb pdb:2KY5|rcsb pdb:5C14|rcsb pdb:5GNI|reactome:R-HSA-114608|reactome:R-HSA-202733|reactome:R-HSA-210990|reactome:R-HSA-216083|reactome:R-HSA-432142|reactome:R-HSA-6798695|refseq:XP_005276937.1|refseq:XP_005276938.1|refseq:XP_005276939.1|refseq:XP_011523191.1|refseq:XP_011523192.1|refseq:XP_016880227.1|refseq:XP_016880228.1|refseq:XP_016880229.1 - - - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/05/24 2018/04/06 rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606 rogid:Rno8MNcOwnEuSww3HPKwGZQQjXc9606 intact-crc:9599EAA803A5203E|rigid:+dEbJff6dc0D7M/cPh5DVyOwuts false mutation disrupting interaction:31-31|glutathione s tranferase tag:?-?|biotin tag:?-?|sufficient binding region:1-106(IPR000980) - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14796 uniprotkb:Q9UIB8 intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906 intact:EBI-6691679|ensembl:ENSP00000312367|uniprotkb:B2R8T1|uniprotkb:B7Z3R8|uniprotkb:O15430|uniprotkb:O95266|uniprotkb:O95660|uniprotkb:Q5H9R1|uniprotkb:Q6FHA8|uniprotkb:Q8WLP1|uniprotkb:Q8WWI8|uniprotkb:Q9UF04|uniprotkb:Q9UIB6|uniprotkb:Q9UIB7|uniprotkb:Q9UIT7 psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym) psi-mi:slaf5_human(display_long)|uniprotkb:CD84(gene name)|psi-mi:CD84(display_short)|uniprotkb:SLAMF5(gene name synonym)|uniprotkb:Cell surface antigen MAX.3(gene name synonym)|uniprotkb:Hly9-beta(gene name synonym)|uniprotkb:Leukocyte differentiation antigen CD84(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule 5(gene name synonym) psi-mi:"MI:0096"(pull down) Schweigel et al. (2013) pubmed:23322602|imex:IM-20819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6691752|imex:IM-20819-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933 refseq:NP_001317671.1|ensembl:ENSG00000066294(gene)|ensembl:ENST00000311224(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0006952"(defense response)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0032685"(negative regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032701"(negative regulation of interleukin-18 production)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043305"(negative regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2PKD|reactome:R-HSA-202733|interpro:IPR003599(Immunoglobulin subtype)|refseq:NP_001171808.1|refseq:NP_001171810.1|refseq:NP_001171811.1|refseq:NP_003865.1|ensembl:ENSG00000066294|ensembl:ENSG00000066294|ensembl:ENSG00000066294|dip:DIP-60957N - - - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/05/24 2018/04/06 rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606 rogid:i4o7JgNmjLKaueK1cKJJllrEERg9606 intact-crc:9599EAA803A5203E|rigid:+dEbJff6dc0D7M/cPh5DVyOwuts false mutation disrupting interaction:31-31|glutathione s tranferase tag:?-?|biotin tag:?-?|sufficient binding region:1-106(IPR000980) - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14796 uniprotkb:Q95866 intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906 intact:EBI-6691731 psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym) psi-mi:q95866_9neob(display_long)|uniprotkb:COI(gene name)|psi-mi:COI(display_short) psi-mi:"MI:0096"(pull down) Schweigel et al. (2013) pubmed:23322602|imex:IM-20819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:51250(neobatrachus sudelli)|taxid:51250(Neobatrachus sudelli) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6691752|imex:IM-20819-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933 go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023616|interpro:IPR036927 - - - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/05/24 2018/04/06 rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606 rogid:3+6I8SM/c06jz/qlN/3MuodAhO851250 intact-crc:9599EAA803A5203E|rigid:+dEbJff6dc0D7M/cPh5DVyOwuts false mutation disrupting interaction:31-31|glutathione s tranferase tag:?-?|biotin tag:?-?|sufficient binding region:1-106(IPR000980) - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14796 uniprotkb:Q99952 intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906 intact:EBI-1384210|uniprotkb:Q53P42|intact:EBI-3959579|uniprotkb:B4E1E6|ensembl:ENSP00000175756 psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym) psi-mi:ptn18_human(display_long)|uniprotkb:Brain-derived phosphatase(gene name synonym)|uniprotkb:PTPN18(gene name)|psi-mi:PTPN18(display_short)|uniprotkb:BDP1(gene name synonym) psi-mi:"MI:0096"(pull down) Schweigel et al. (2013) pubmed:23322602|imex:IM-20819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6691752|imex:IM-20819-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933 refseq:NP_055184.2|refseq:NP_001135842.1|ensembl:ENSG00000072135(gene)|ensembl:ENST00000175756(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:1901185"(negative regulation of ERBB signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:Q99952|rcsb pdb:2OC3|rcsb pdb:4GFU|rcsb pdb:4GFV|rcsb pdb:4NND|reactome:R-HSA-8863795|reactome:R-HSA-9008059 - - - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/05/24 2018/04/06 rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606 rogid:xRrifp9kOwi0SLtlIFtSjiv4qN89606 intact-crc:9599EAA803A5203E|rigid:+dEbJff6dc0D7M/cPh5DVyOwuts false mutation disrupting interaction:31-31|glutathione s tranferase tag:?-?|biotin tag:?-?|sufficient binding region:1-106(IPR000980) - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification)