#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q53GL7	uniprotkb:P55212	intact:EBI-2857573|uniprotkb:Q8N2I0|uniprotkb:Q8WV05|uniprotkb:Q96CH7|uniprotkb:Q96K72|ensembl:ENSP00000325618	intact:EBI-718729|uniprotkb:Q9BQE7|ensembl:ENSP00000265164	psi-mi:par10_human(display_long)|uniprotkb:Poly [ADP-ribose] polymerase 10(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 10(gene name synonym)|uniprotkb:PARP10(gene name)|psi-mi:PARP10(display_short)	psi-mi:casp6_human(display_long)|uniprotkb:Apoptotic protease Mch-2(gene name synonym)|uniprotkb:CASP6(gene name)|psi-mi:CASP6(display_short)|uniprotkb:MCH2(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Herzog et al. (2013)	mint:fj-12-0733|pubmed:23305266|mint:MINT-8408758	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8297825|mint:MINT-8408763	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116178.2|go:"GO:0034356"(NAD biosynthesis via nicotinamide riboside salvage pathway)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034464|rcsb pdb:2DHX|rcsb pdb:3HKV|rcsb pdb:5LX6|rcsb pdb:6FXI|reactome:R-HSA-197264|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENSG00000178685(gene)|ensembl:ENST00000313028(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010847"(regulation of chromatin assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0019985"(translesion synthesis)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|mint:MINT-8408788(identity)	refseq:NP_001217.2|refseq:NP_116787.1|rcsb pdb:3K7E|rcsb pdb:3NKF|rcsb pdb:3NR2|rcsb pdb:3OD5|rcsb pdb:3P45|rcsb pdb:3P4U|rcsb pdb:3QNW|rcsb pdb:3S70|rcsb pdb:3S8E|rcsb pdb:3V6L|rcsb pdb:3V6M|rcsb pdb:4EJF|rcsb pdb:4FXO|rcsb pdb:4HVA|rcsb pdb:4IYR|rcsb pdb:4N5D|rcsb pdb:4N6G|rcsb pdb:4N7J|rcsb pdb:4N7M|rcsb pdb:4NBK|rcsb pdb:4NBL|rcsb pdb:4NBN|rcsb pdb:6DEU|rcsb pdb:6DEV|reactome:R-HSA-111465|reactome:R-HSA-264870|reactome:R-HSA-352238|reactome:R-HSA-6803207|ensembl:ENSG00000138794(gene)|ensembl:ENST00000265164(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR037554|mint:P55212|rcsb pdb:1MI9|rcsb pdb:2WDP|dip:DIP-44649N|mint:MINT-8408765(identity)	-	-	-	figure legend:f4b|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/01/10	2014/10/16	rogid:WcJRnNPrEAYD6vk9c4ACoh5fX1U9606	rogid:x335dTT6omZBrEGs7jzxOjUWaNM9606	intact-crc:14F362A82D615915|rigid:+bhLrHe/efqvIg+YK7NJv88MfxU	false	glutathione s tranferase tag:?-?(MINT-8408791)|binding-associated region:206-459(MINT-8408794)	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q53GL7	uniprotkb:Q14790	intact:EBI-2857573|uniprotkb:Q8N2I0|uniprotkb:Q8WV05|uniprotkb:Q96CH7|uniprotkb:Q96K72|ensembl:ENSP00000325618	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	psi-mi:par10_human(display_long)|uniprotkb:Poly [ADP-ribose] polymerase 10(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 10(gene name synonym)|uniprotkb:PARP10(gene name)|psi-mi:PARP10(display_short)	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Herzog et al. (2013)	mint:fj-12-0733|pubmed:23305266|mint:MINT-8408758	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8297863|mint:MINT-8408798	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116178.2|go:"GO:0034356"(NAD biosynthesis via nicotinamide riboside salvage pathway)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034464|rcsb pdb:2DHX|rcsb pdb:3HKV|rcsb pdb:5LX6|rcsb pdb:6FXI|reactome:R-HSA-197264|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENSG00000178685(gene)|ensembl:ENST00000313028(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010847"(regulation of chromatin assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0019985"(translesion synthesis)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|mint:MINT-8408800(identity)	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N|mint:MINT-8408806(identity)	-	-	-	figure legend:f4b|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/01/10	2014/10/16	rogid:WcJRnNPrEAYD6vk9c4ACoh5fX1U9606	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	intact-crc:07F875FD0992D07B|rigid:P23ui6K+j/331ZV1cwyPyrmgpjE	false	glutathione s tranferase tag:?-?(MINT-8408803)|binding-associated region:206-459(MINT-8408801)	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0396"(predetermined participant)