#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:16024"	uniprotkb:Q59GS1	intact:EBI-2679332	intact:EBI-6677245	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:q59gs1_human(display_long)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	-	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:0SE3Ycq4Y5UsscZ5FXxuS+AAy2c9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P04217	intact:EBI-2679332	intact:EBI-3925937|uniprotkb:Q8IYJ6|uniprotkb:Q96P39|uniprotkb:Q68CK0|uniprotkb:A8K052|ensembl:ENSP00000263100	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:a1bg_human(display_long)|uniprotkb:A1BG(gene name)|psi-mi:A1BG(display_short)|uniprotkb:Alpha-1-B glycoprotein(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_570602.2|ensembl:ENSG00000121410(gene)|ensembl:ENST00000263100(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016332(Alpha-1B-glycoprotein/leukocyte immunoglobulin-like receptor)|interpro:IPR036179|reactome:R-HSA-114608|reactome:R-HSA-6798695	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:N/9VdAtd5nX1Ur1GLmb18hpbQrs9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P01042	intact:EBI-2679332	intact:EBI-6378713|ensembl:ENSP00000493985|uniprotkb:C9JEX1|uniprotkb:A8K474|uniprotkb:B2RCR2|uniprotkb:P01043|uniprotkb:Q53EQ0|uniprotkb:Q6PAU9|uniprotkb:Q7M4P1	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:kng1_human(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000113889(gene)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENST00000644859(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042311"(vasodilation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR002395(HMW kininogen)|interpro:IPR018073|interpro:IPR027358|mint:P01042|rcsb pdb:1NY2|rcsb pdb:2WOK|rcsb pdb:4ASQ|rcsb pdb:4ASR|rcsb pdb:4ECB|rcsb pdb:4ECC|rcsb pdb:5I25|rcsb pdb:6F27|rcsb pdb:6F3V|rcsb pdb:6F3W|rcsb pdb:6F3X|rcsb pdb:6F3Y|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-375276|reactome:R-HSA-381426|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-8957275|go:"GO:0005615"(extracellular space)|refseq:NP_000884.1|refseq:NP_001095886.1|refseq:NP_001159923.1	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:Z/DOKINto4Ygn9lYUu6nuHA3soM9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P68036	intact:EBI-2679332	intact:EBI-711173|uniprotkb:P51966|uniprotkb:P70653|uniprotkb:Q9HAV1|ensembl:ENSP00000344259|uniprotkb:B2R4A7|uniprotkb:B4DDG1|uniprotkb:B4DSZ4|uniprotkb:E7EWS7	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:ub2l3_human(display_long)|uniprotkb:Ubiquitin-protein ligase L3(gene name synonym)|uniprotkb:Ubiquitin carrier protein L3(gene name synonym)|uniprotkb:UbcH7(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-F1(gene name synonym)|uniprotkb:L-UBC(gene name synonym)|uniprotkb:UBE2L3(gene name)|psi-mi:UBE2L3(display_short)|uniprotkb:UBCE7(gene name synonym)|uniprotkb:UBCH7(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme L3(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003338.1|ensembl:ENSG00000185651(gene)|ensembl:ENST00000342192(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1C4Z|rcsb pdb:1FBV|rcsb pdb:3SQV|rcsb pdb:3SY2|rcsb pdb:4Q5E|rcsb pdb:4Q5H|rcsb pdb:5HPT|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:6CP2|rcsb pdb:6DJW|rcsb pdb:6DJX|rcsb pdb:6N13|rcsb pdb:6XXU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|refseq:NP_001243284.1|refseq:NP_001243285.1|dip:DIP-6124N	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:Axu5Wl2I4nl2wCfMQqYGRBKP6P49606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02647	intact:EBI-2679332	intact:EBI-701692|uniprotkb:Q6LDN9|uniprotkb:Q6Q785|uniprotkb:A8K866|uniprotkb:Q9UCS8|uniprotkb:Q9UCT8|ensembl:ENSP00000236850|ensembl:ENSP00000352471|ensembl:ENSP00000364469|ensembl:ENSP00000364472	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:apoa1_human(display_long)|uniprotkb:APOA1(gene name)|psi-mi:APOA1(display_short)|uniprotkb:Apolipoprotein A1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000030.1|refseq:NP_001304946.1|refseq:NP_001304947.1|refseq:NP_001304950.1|dip:DIP-29619N|ensembl:ENSG00000118137(gene)|ensembl:ENST00000236850(transcript)|ensembl:ENST00000359492(transcript)|ensembl:ENST00000375320(transcript)|ensembl:ENST00000375323(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0009986"(cell surface)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0018206"(peptidyl-methionine modification)|go:"GO:0019899"(enzyme binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030325"(adrenal gland development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051180"(vitamin transport)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070508"(cholesterol import)|go:"GO:0070653"(high-density lipoprotein particle receptor binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0072562"(blood microparticle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P02647|rcsb pdb:1AV1|rcsb pdb:1GW3|rcsb pdb:1GW4|rcsb pdb:1ODP|rcsb pdb:1ODQ|rcsb pdb:1ODR|rcsb pdb:2MSC|rcsb pdb:2MSD|rcsb pdb:2MSE|rcsb pdb:2N5E|rcsb pdb:3K2S|rcsb pdb:3R2P|rcsb pdb:4V6M|rcsb pdb:6CC9|rcsb pdb:6CCH|rcsb pdb:6CCX|rcsb pdb:6CLZ|rcsb pdb:6CM1|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6W4E|rcsb pdb:6W4F|rcsb pdb:7KJR|reactome:R-HSA-114608|reactome:R-HSA-1369062|reactome:R-HSA-1989781|reactome:R-HSA-2168880|reactome:R-HSA-3000471|reactome:R-HSA-3000480|reactome:R-HSA-381426|reactome:R-HSA-5682113|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963896|reactome:R-HSA-8963901|reactome:R-HSA-8964011|reactome:R-HSA-8964058|reactome:R-HSA-9707616|reactome:R-HSA-975634|reactome:R-HSA-977225	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:yEzPDeU8Uu/43dkLLOBAy6ey1vs9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q7Z351	intact:EBI-2679332	intact:EBI-6677357	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:q7z351_human(display_long)|uniprotkb:DKFZp686N02209(gene name)|psi-mi:DKFZp686N02209(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0016020"(membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:vwyOd/7l5spXu22MzBnwLTwczo49606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q96K68	intact:EBI-2679332	intact:EBI-6677510	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:q96k68_human(display_long)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0016020"(membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:XTdU4HvBRVgwVBfrDLnQRg1GPn09606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P35542	intact:EBI-2679332	intact:EBI-750242|uniprotkb:Q6FHJ4|ensembl:ENSP00000278222	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:saa4_human(display_long)|uniprotkb:Constitutively expressed serum amyloid A protein(gene name synonym)|uniprotkb:SAA4(gene name)|psi-mi:SAA4(display_short)|uniprotkb:CSAA(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006503.2|ensembl:ENSG00000148965(gene)|ensembl:ENST00000278222(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0006953"(acute-phase response)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000096(Serum amyloid A protein)	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:ZOkx4/kGh+VTTXdEMq1GjT4ASl49606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P00734	intact:EBI-2679332	intact:EBI-297094|ensembl:ENSP00000308541|uniprotkb:B2R7F7|uniprotkb:B4E1A7|uniprotkb:Q4QZ40|uniprotkb:Q53H04|uniprotkb:Q53H06|uniprotkb:Q7Z7P3|uniprotkb:Q9UCA1|uniprotkb:Q69EZ7	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:thrb_human(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:1BTH|rcsb pdb:1C1U|rcsb pdb:1C1V|rcsb pdb:1C1W|rcsb pdb:1C4U|rcsb pdb:1C4V|rcsb pdb:1C4Y|rcsb pdb:1C5L|rcsb pdb:1C5N|rcsb pdb:1C5O|rcsb pdb:1CA8|rcsb pdb:1D3D|rcsb pdb:1D3P|rcsb pdb:1D3Q|rcsb pdb:1D3T|rcsb pdb:1D4P|rcsb pdb:1D6W|rcsb pdb:1BMN|rcsb pdb:1D9I|rcsb pdb:1DE7|rcsb pdb:1DIT|rcsb pdb:1DM4|rcsb pdb:1DOJ|rcsb pdb:1DWB|rcsb pdb:1DWC|rcsb pdb:1DWD|rcsb pdb:1LHF|rcsb pdb:1LHG|rcsb pdb:1MH0|rcsb pdb:1MU6|rcsb pdb:1MU8|rcsb pdb:1MUE|rcsb pdb:1NM6|rcsb pdb:1NO9|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|rcsb pdb:1NRR|rcsb pdb:1NRS|rcsb pdb:1DWE|rcsb pdb:1NT1|rcsb pdb:1NU7|rcsb pdb:1NU9|rcsb pdb:1KTT|rcsb pdb:1LHC|rcsb pdb:1NY2|rcsb pdb:1NZQ|rcsb pdb:1LHD|rcsb pdb:1O0D|rcsb pdb:1O2G|rcsb pdb:1LHE|rcsb pdb:1O5G|rcsb pdb:1OOK|rcsb pdb:1OYT|rcsb pdb:1P8V|rcsb pdb:1PPB|rcsb pdb:1HAG|rcsb pdb:1HAH|rcsb pdb:1DX5|rcsb pdb:1E0F|rcsb pdb:1EB1|rcsb pdb:1HAI|rcsb pdb:1HAO|rcsb pdb:1EOJ|rcsb pdb:1EOL|rcsb pdb:1FPC|rcsb pdb:1FPH|rcsb pdb:1HAP|rcsb pdb:1HBT|rcsb pdb:1G30|rcsb pdb:1G32|rcsb pdb:1G37|rcsb pdb:1GHV|rcsb pdb:1HDT|rcsb pdb:1HGT|rcsb pdb:1GHW|rcsb pdb:1GHX|rcsb pdb:1GHY|rcsb pdb:1GJ4|rcsb pdb:1GJ5|rcsb pdb:1HLT|rcsb pdb:1HUT|rcsb pdb:1HXE|rcsb pdb:1HXF|rcsb pdb:1IHS|rcsb pdb:1IHT|rcsb pdb:1H8D|rcsb pdb:1H8I|rcsb pdb:1JMO|rcsb pdb:1JOU|rcsb pdb:1JWT|rcsb pdb:1K21|rcsb pdb:1K22|rcsb pdb:1KTS|ensembl:ENST00000311907(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|ensembl:ENSG00000180210(gene)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0072562"(blood microparticle)|go:"GO:0042730"(fibrinolysis)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|rcsb pdb:1A3B|rcsb pdb:1A3E|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|rcsb pdb:1A46|rcsb pdb:1A4W|interpro:IPR018056|rcsb pdb:1A5G|rcsb pdb:1A61|rcsb pdb:1ABI|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|rcsb pdb:1ABJ|rcsb pdb:1AD8|interpro:IPR035972|rcsb pdb:1AE8|rcsb pdb:1AFE|rcsb pdb:1AHT|rcsb pdb:1AI8|rcsb pdb:1AIX|rcsb pdb:1AWF|rcsb pdb:1AWH|rcsb pdb:1AY6|interpro:IPR037111|rcsb pdb:1B5G|rcsb pdb:1B7X|rcsb pdb:1BA8|rcsb pdb:1BB0|rcsb pdb:1BCU|interpro:IPR038178|rcsb pdb:1BHX|interpro:IPR043504|mint:P00734|rcsb pdb:1BMM|rcsb pdb:1A2C|rcsb pdb:2ZI2|rcsb pdb:2ZIQ|rcsb pdb:2ZNK|rcsb pdb:2ZO3|rcsb pdb:3B23|rcsb pdb:2ZHW|rcsb pdb:3B9F|rcsb pdb:3BEF|rcsb pdb:3BEI|rcsb pdb:3BF6|rcsb pdb:3BIU|rcsb pdb:3BIV|rcsb pdb:3BV9|rcsb pdb:3C1K|rcsb pdb:3C27|rcsb pdb:3D49|rcsb pdb:3DA9|rcsb pdb:3DD2|rcsb pdb:3DHK|rcsb pdb:3DT0|rcsb pdb:3DUX|rcsb pdb:3E6P|rcsb pdb:3EE0|rcsb pdb:3EGK|rcsb pdb:3EQ0|rcsb pdb:3F68|rcsb pdb:3GIC|rcsb pdb:3GIS|rcsb pdb:3HAT|rcsb pdb:3HKJ|rcsb pdb:3HTC|rcsb pdb:3JZ1|rcsb pdb:3JZ2|rcsb pdb:3K65|rcsb pdb:3LDX|rcsb pdb:3LU9|rcsb pdb:3NXP|rcsb pdb:3P17|rcsb pdb:3P6Z|rcsb pdb:3P70|rcsb pdb:3PMH|rcsb pdb:3PO1|rcsb pdb:3QDZ|rcsb pdb:3QGN|rcsb pdb:3QLP|rcsb pdb:3QTO|rcsb pdb:3QTV|rcsb pdb:3QWC|rcsb pdb:3QX5|rcsb pdb:1QBV|rcsb pdb:1QHR|rcsb pdb:1QJ1|rcsb pdb:1QJ6|rcsb pdb:1TB6|rcsb pdb:1QJ7|rcsb pdb:1QUR|rcsb pdb:1RD3|rcsb pdb:1TBZ|rcsb pdb:1RIW|rcsb pdb:1THP|rcsb pdb:1THR|rcsb pdb:1THS|rcsb pdb:1SB1|rcsb pdb:1SFQ|rcsb pdb:1SG8|rcsb pdb:1SGI|rcsb pdb:1SHH|rcsb pdb:1TMB|rcsb pdb:1SL3|rcsb pdb:1SR5|rcsb pdb:1T4U|rcsb pdb:1T4V|rcsb pdb:1TA2|rcsb pdb:1TMT|rcsb pdb:1TMU|rcsb pdb:1TOM|rcsb pdb:1TQ0|rcsb pdb:1TQ7|rcsb pdb:1TWX|rcsb pdb:1UMA|rcsb pdb:1UVS|rcsb pdb:1VR1|rcsb pdb:1VZQ|rcsb pdb:1W7G|rcsb pdb:1WAY|rcsb pdb:1WBG|rcsb pdb:1XM1|rcsb pdb:1XMN|rcsb pdb:1YPE|rcsb pdb:1YPG|rcsb pdb:1YPJ|rcsb pdb:1YPK|rcsb pdb:1YPL|rcsb pdb:1TA6|rcsb pdb:1YPM|rcsb pdb:1Z71|rcsb pdb:2AFQ|rcsb pdb:2ANK|rcsb pdb:2ANM|rcsb pdb:2B5T|rcsb pdb:2BDY|rcsb pdb:2BVR|rcsb pdb:2BVS|rcsb pdb:2BVX|rcsb pdb:2BXT|rcsb pdb:2BXU|rcsb pdb:2C8W|rcsb pdb:2C8X|rcsb pdb:2C8Y|rcsb pdb:2C8Z|rcsb pdb:2C90|rcsb pdb:2C93|rcsb pdb:2CF8|rcsb pdb:2CF9|rcsb pdb:1Z8I|rcsb pdb:2CN0|rcsb pdb:2FEQ|rcsb pdb:1Z8J|rcsb pdb:1ZGI|rcsb pdb:1ZGV|rcsb pdb:1ZRB|rcsb pdb:2A0Q|rcsb pdb:2A2X|rcsb pdb:2FES|rcsb pdb:2GDE|rcsb pdb:2GP9|rcsb pdb:2A45|rcsb pdb:2H9T|rcsb pdb:2HGT|rcsb pdb:2HNT|rcsb pdb:2HPP|rcsb pdb:2HPQ|rcsb pdb:2HWL|rcsb pdb:3RLW|rcsb pdb:3RLY|rcsb pdb:3RM0|rcsb pdb:3R3G|rcsb pdb:3RM2|rcsb pdb:3RML|rcsb pdb:3RMM|rcsb pdb:3RMN|rcsb pdb:3RMO|rcsb pdb:3S7H|rcsb pdb:3S7K|rcsb pdb:3SHA|rcsb pdb:3SHC|rcsb pdb:3SI3|rcsb pdb:3SI4|rcsb pdb:3SQE|rcsb pdb:3SQH|rcsb pdb:3SV2|rcsb pdb:3T5F|rcsb pdb:3TU7|rcsb pdb:3U69|rcsb pdb:3U8O|rcsb pdb:3U8R|rcsb pdb:3U8T|rcsb pdb:3U98|rcsb pdb:3U9A|rcsb pdb:3UTU|rcsb pdb:3UWJ|rcsb pdb:3VXE|rcsb pdb:3VXF|rcsb pdb:4AX9|rcsb pdb:4AYV|rcsb pdb:4AYY|rcsb pdb:4AZ2|rcsb pdb:4BAH|rcsb pdb:4BAK|rcsb pdb:4BAM|rcsb pdb:4BAN|rcsb pdb:4BAO|rcsb pdb:4BAQ|rcsb pdb:4BOH|rcsb pdb:4CH2|rcsb pdb:4CH8|rcsb pdb:4DIH|rcsb pdb:4DII|rcsb pdb:4DT7|rcsb pdb:4DY7|rcsb pdb:4E05|rcsb pdb:4E7R|rcsb pdb:4H6S|rcsb pdb:4H6T|rcsb pdb:4HFP|rcsb pdb:4HTC|rcsb pdb:4HZH|rcsb pdb:4I7Y|rcsb pdb:4LOY|rcsb pdb:4LXB|rcsb pdb:4LZ1|rcsb pdb:4LZ4|rcsb pdb:4MLF|rcsb pdb:4NZQ|rcsb pdb:4O03|rcsb pdb:4RKJ|rcsb pdb:4RKO|rcsb pdb:4RN6|rcsb pdb:4THN|rcsb pdb:4UD9|rcsb pdb:4UDW|rcsb pdb:4UE7|rcsb pdb:4UEH|rcsb pdb:4UFD|rcsb pdb:4UFE|rcsb pdb:4UFF|rcsb pdb:4UFG|rcsb pdb:4YES|rcsb pdb:5A2M|rcsb pdb:5AF9|rcsb pdb:4E06|rcsb pdb:5AFY|rcsb pdb:5AHG|rcsb pdb:5CMX|rcsb pdb:5DO4|rcsb pdb:5E8E|rcsb pdb:5EDK|rcsb pdb:5EDM|rcsb pdb:5EW1|rcsb pdb:5EW2|rcsb pdb:5GDS|rcsb pdb:5GIM|rcsb pdb:5JDU|rcsb pdb:5JFD|rcsb pdb:5JZY|rcsb pdb:5L6N|rcsb pdb:5MJT|rcsb pdb:5MLS|rcsb pdb:5MM6|rcsb pdb:5NHU|rcsb pdb:5TO3|rcsb pdb:5Z5W|rcsb pdb:5Z5X|rcsb pdb:6BJR|rcsb pdb:6C2W|rcsb pdb:6EO6|rcsb pdb:6EO7|rcsb pdb:6EO8|rcsb pdb:6EO9|rcsb pdb:6V5T|rcsb pdb:7KME|rcsb pdb:8KME|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-416476|rcsb pdb:5AFZ|rcsb pdb:2JH5|rcsb pdb:2JH6|rcsb pdb:2OD3|rcsb pdb:2PGB|rcsb pdb:2PGQ|rcsb pdb:2PKS|rcsb pdb:2PW8|rcsb pdb:2R2M|rcsb pdb:2THF|rcsb pdb:2UUF|rcsb pdb:2UUJ|rcsb pdb:2UUK|rcsb pdb:2V3H|rcsb pdb:2V3O|rcsb pdb:2ZC9|rcsb pdb:2ZDA|rcsb pdb:2ZDV|rcsb pdb:2ZF0|rcsb pdb:2ZFF|rcsb pdb:2ZFP|rcsb pdb:2ZFQ|rcsb pdb:2ZFR|rcsb pdb:2ZG0|rcsb pdb:2JH0|rcsb pdb:2ZGB|rcsb pdb:2ZGX|rcsb pdb:2ZHE|rcsb pdb:2ZHF|rcsb pdb:2ZHQ|reactome:R-HSA-76009|reactome:R-HSA-9657688|reactome:R-HSA-9672391|reactome:R-HSA-977606|reactome:R-HSA-456926|refseq:NP_000497.1|refseq:NP_001298186.1|dip:DIP-6115N	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:f6OQ6v3WbFpxr7N6GhfZOHjSsTQ9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q14624	intact:EBI-2679332	intact:EBI-2115630|uniprotkb:Q15135|uniprotkb:Q9P190|uniprotkb:Q9UQ54|uniprotkb:B7Z545|uniprotkb:E9PGN5|ensembl:ENSP00000266041	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:itih4_human(display_long)|uniprotkb:ITIH4(gene name)|psi-mi:ITIH4(display_short)|uniprotkb:IHRP(gene name synonym)|uniprotkb:ITIHL1(gene name synonym)|uniprotkb:PK120(gene name synonym)|uniprotkb:Inter-alpha-trypsin inhibitor family heavy chain-related protein(gene name synonym)|uniprotkb:Plasma kallikrein sensitive glycoprotein 120(gene name synonym)|uniprotkb:PRO1851(orf name)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002209.2|refseq:NP_001159921.1|ensembl:ENSG00000055955(gene)|ensembl:ENST00000266041(transcript)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006953"(acute-phase response)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010600(Inter-alpha-trypsin inhibitor heavy chain, C-terminal)|interpro:IPR013694(Vault protein inter-alpha-trypsin)|interpro:IPR036465|reactome:R-HSA-114608	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:eodZ+5rGLYkRTWAyHhnDazwtLaA9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P00747	intact:EBI-2679332	intact:EBI-999394|uniprotkb:Q15146|uniprotkb:Q5TEH4|uniprotkb:Q6PA00|ensembl:ENSP00000308938	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:plmn_human(display_long)|uniprotkb:PLG(gene name)|psi-mi:PLG(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000292.1|ensembl:ENSG00000122194(gene)|ensembl:ENST00000308192(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007596"(blood coagulation)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0042730"(fibrinolysis)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0048771"(tissue remodeling)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0051919"(positive regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1990405"(protein antigen binding)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000001(Kringle)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003609(Apple-like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR023317|interpro:IPR033116|interpro:IPR038178|interpro:IPR043504|mint:P00747|rcsb pdb:1B2I|rcsb pdb:1BML|rcsb pdb:1BUI|rcsb pdb:1CEA|rcsb pdb:1CEB|rcsb pdb:1DDJ|rcsb pdb:1HPJ|rcsb pdb:1HPK|rcsb pdb:1I5K|rcsb pdb:1KI0|rcsb pdb:1KRN|rcsb pdb:1L4D|rcsb pdb:1L4Z|rcsb pdb:1PK4|rcsb pdb:1PKR|rcsb pdb:1PMK|rcsb pdb:1QRZ|rcsb pdb:1RJX|rcsb pdb:2DOH|rcsb pdb:2DOI|rcsb pdb:2KNF|rcsb pdb:2L0S|rcsb pdb:2PK4|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|rcsb pdb:3UIR|rcsb pdb:4A5T|rcsb pdb:4CIK|rcsb pdb:4DCB|rcsb pdb:4DUR|rcsb pdb:4DUU|rcsb pdb:5HPG|rcsb pdb:5UGD|rcsb pdb:5UGG|rcsb pdb:6D3X|rcsb pdb:6D3Y|rcsb pdb:6D3Z|rcsb pdb:6D40|rcsb pdb:6OG4|rcsb pdb:6OQJ|rcsb pdb:6OQK|rcsb pdb:6Q1U|rcsb pdb:6UZ4|rcsb pdb:6UZ5|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-186797|reactome:R-HSA-381426|reactome:R-HSA-75205	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:f9Y+uCcA1jrDN1AD/clsKtkZWEQ9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P19652	intact:EBI-2679332	intact:EBI-3911979|ensembl:ENSP00000394936|uniprotkb:Q16571|uniprotkb:B2R5L2|uniprotkb:Q5T538|uniprotkb:Q6IB74	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:a1ag2_human(display_long)|uniprotkb:ORM2(gene name)|psi-mi:ORM2(display_short)|uniprotkb:AGP2(gene name synonym)|uniprotkb:Orosomucoid-2(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000228278(gene)|ensembl:ENST00000431067(transcript)|go:"GO:0002682"(regulation of immune system process)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR001500(Alpha-1-acid glycoprotein)|interpro:IPR012674(Calycin)|rcsb pdb:3APU|rcsb pdb:3APV|rcsb pdb:3APW|rcsb pdb:3APX|reactome:R-HSA-114608|reactome:R-HSA-6798695|refseq:NP_000599.1	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:czaqFtbhDCa8W9C4S2+784TbDAM9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:O95445	intact:EBI-2679332	intact:EBI-715018|uniprotkb:Q9P046|uniprotkb:Q9UMP6|uniprotkb:B0UX98|ensembl:ENSP00000365081|ensembl:ENSP00000372930|ensembl:ENSP00000389591|ensembl:ENSP00000394610|ensembl:ENSP00000398944|ensembl:ENSP00000401684|ensembl:ENSP00000405730|uniprotkb:Q5SRP4	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:apom_human(display_long)|uniprotkb:Protein G3a(gene name synonym)|uniprotkb:APOM(gene name)|psi-mi:APOM(display_short)|uniprotkb:G3A(gene name synonym)|uniprotkb:NG20(gene name synonym)|uniprotkb:HSPC336(orf name)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_061974.2|refseq:NP_001243098.1|ensembl:ENSG00000204444(gene)|ensembl:ENSG00000206409(gene)|ensembl:ENSG00000226215(gene)|ensembl:ENSG00000224290(gene)|ensembl:ENSG00000227567(gene)|ensembl:ENSG00000231974(gene)|ensembl:ENSG00000235754(gene)|ensembl:ENST00000375916(transcript)|ensembl:ENST00000383438(transcript)|ensembl:ENST00000426800(transcript)|ensembl:ENST00000430282(transcript)|ensembl:ENST00000432598(transcript)|ensembl:ENST00000436931(transcript)|ensembl:ENST00000441436(transcript)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0009749"(response to glucose)|go:"GO:0016209"(antioxidant activity)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034445"(negative regulation of plasma lipoprotein oxidation)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043691"(reverse cholesterol transport)|interpro:IPR012674(Calycin)|interpro:IPR022734|rcsb pdb:2WEW|rcsb pdb:2WEX|rcsb pdb:2YG2|reactome:R-HSA-975634	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:7NkqD+U3JA6Sti7JufvvOfwKI6U9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P09871	intact:EBI-2679332	intact:EBI-2810045|uniprotkb:Q9UCU9|uniprotkb:Q9UCV3|uniprotkb:Q9UCU7|uniprotkb:Q9UCV5|uniprotkb:Q9UCV4|uniprotkb:Q9UCU8|uniprotkb:Q9UCV2|uniprotkb:Q9UCV1|uniprotkb:Q9UCV0|uniprotkb:Q9UM14|uniprotkb:D3DUT4|ensembl:ENSP00000328173|ensembl:ENSP00000354057|ensembl:ENSP00000385035	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:c1s_human(display_long)|uniprotkb:C1S(gene name)|psi-mi:C1S(display_short)|uniprotkb:C1 esterase(gene name synonym)|uniprotkb:Complement component 1 subcomponent s(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001725.1|refseq:NP_958850.1|ensembl:ENSG00000182326(gene)|ensembl:ENST00000328916(transcript)|ensembl:ENST00000360817(transcript)|ensembl:ENST00000406697(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035708|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:1ELV|rcsb pdb:1NZI|rcsb pdb:4J1Y|rcsb pdb:4LMF|rcsb pdb:4LOR|rcsb pdb:4LOS|rcsb pdb:4LOT|rcsb pdb:6F1C|rcsb pdb:6F1H|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|refseq:NP_001333779.1|refseq:XP_005253817.1	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:3zz5RwIqLyPO71zdCp5Vx7aVl+Y9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:A0A5E4	intact:EBI-2679332	intact:EBI-6677170	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:a0a5e4_human(display_long)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0016020"(membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:lhrQIB2KZ4isPPMA91Yx4AIBG309606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P0C0L4	intact:EBI-2679332	intact:EBI-1223619|uniprotkb:P01028|uniprotkb:P78445|uniprotkb:Q13160|uniprotkb:Q13906|uniprotkb:Q14033|uniprotkb:Q14835|uniprotkb:Q5JQM8|uniprotkb:Q9NPK5|uniprotkb:Q9UIP5|uniprotkb:B0QZR6|uniprotkb:A6H8M8|uniprotkb:A6NHJ5|uniprotkb:A7E2V2|uniprotkb:B0V2C8|uniprotkb:B2RUT6|uniprotkb:B7ZVZ6|uniprotkb:Q4LE82|uniprotkb:Q5JNX2|uniprotkb:Q6P4R1|uniprotkb:Q6U2E5|uniprotkb:Q6U2E8|uniprotkb:Q6U2F0|uniprotkb:Q6U2F3|uniprotkb:Q6U2F4|uniprotkb:Q6U2F6|uniprotkb:Q6U2F8|uniprotkb:Q6U2G0|uniprotkb:Q96EG2|uniprotkb:Q96SA8|ensembl:ENSP00000388662|ensembl:ENSP00000396688|ensembl:ENSP00000372815	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:co4a_human(display_long)|uniprotkb:C4A(gene name)|psi-mi:C4A(display_short)|uniprotkb:CO4(gene name synonym)|uniprotkb:CPAMD2(gene name synonym)|uniprotkb:Acidic complement C4(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009224.2|refseq:NP_001002029.3|refseq:NP_001239133.1|ensembl:ENSG00000206340(gene)|ensembl:ENSG00000227746(gene)|ensembl:ENSG00000244731(gene)|ensembl:ENST00000383325(transcript)|ensembl:ENST00000421274(transcript)|ensembl:ENST00000428956(transcript)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR036595|interpro:IPR037569|interpro:IPR040839|interpro:IPR041555|rcsb pdb:1HZF|rcsb pdb:4FXG|rcsb pdb:4FXK|rcsb pdb:4XAM|rcsb pdb:5JPM|rcsb pdb:5JPN|rcsb pdb:5JTW|reactome:R-HSA-166663|reactome:R-HSA-174577|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-977606	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:nLlIFlW5RCngnXASkYPGREjA/1E9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02768	intact:EBI-2679332	intact:EBI-714423|ensembl:ENSP00000295897|uniprotkb:Q645G4|uniprotkb:O95574|uniprotkb:P04277|uniprotkb:Q13140|uniprotkb:Q68DN5|uniprotkb:Q6UXK4|uniprotkb:Q86YG0|uniprotkb:Q9P157|uniprotkb:Q9P1I7|uniprotkb:Q9UHS3|uniprotkb:Q9UJZ0|intact:EBI-7301844|intact:MINT-1161169|uniprotkb:E7ESS9|uniprotkb:Q8IUK7	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:albu_human(display_long)|uniprotkb:GIG42(orf name)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:PRO0903(orf name)|uniprotkb:PRO1708(orf name)|uniprotkb:PRO2044(orf name)|uniprotkb:PRO2619(orf name)|uniprotkb:PRO2675(orf name)|uniprotkb:UNQ696/PRO1341(orf name)|uniprotkb:GIG20(orf name)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000163631(gene)|ensembl:ENST00000295897(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|rcsb pdb:1E78|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016209"(antioxidant activity)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0051087"(chaperone binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140272"(exogenous protein binding)|go:"GO:1903981"(enterobactin binding)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|interpro:IPR021177|mint:P02768|rcsb pdb:1AO6|rcsb pdb:1BJ5|rcsb pdb:1BKE|rcsb pdb:1BM0|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|rcsb pdb:6XV0|rcsb pdb:6YG9|rcsb pdb:6ZL1|rcsb pdb:7A9C|rcsb pdb:7AAE|rcsb pdb:7AAI|rcsb pdb:7D6J|rcsb pdb:7JWN|reactome:R-HSA-114608|reactome:R-HSA-159418|reactome:R-HSA-189451|reactome:R-HSA-189483|reactome:R-HSA-2168880|reactome:R-HSA-381426|reactome:R-HSA-879518|reactome:R-HSA-8957275|reactome:R-HSA-8964058|reactome:R-HSA-9707564|rcsb pdb:6WUW|rcsb pdb:1E7B|rcsb pdb:1E7C|rcsb pdb:1E7E|rcsb pdb:1E7F|rcsb pdb:1E7G|rcsb pdb:1E7H|rcsb pdb:1E7I|rcsb pdb:1GNI|rcsb pdb:1GNJ|rcsb pdb:1H9Z|rcsb pdb:1HA2|rcsb pdb:1HK1|rcsb pdb:1HK2|rcsb pdb:1HK3|rcsb pdb:1HK4|rcsb pdb:1HK5|rcsb pdb:1N5U|rcsb pdb:1O9X|rcsb pdb:1TF0|rcsb pdb:1UOR|rcsb pdb:1YSX|rcsb pdb:2BX8|rcsb pdb:2BXA|rcsb pdb:2BXB|rcsb pdb:2BXC|rcsb pdb:2BXD|rcsb pdb:1E7A|rcsb pdb:2BXE|rcsb pdb:2BXF|rcsb pdb:2BXG|rcsb pdb:2BXH|rcsb pdb:2BXI|rcsb pdb:2BXK|rcsb pdb:2BXL|rcsb pdb:2BXM|rcsb pdb:2BXN|rcsb pdb:2BXO|rcsb pdb:2BXP|rcsb pdb:2BXQ|rcsb pdb:2ESG|rcsb pdb:2I2Z|rcsb pdb:2I30|rcsb pdb:2N0X|rcsb pdb:2VDB|rcsb pdb:2VUE|rcsb pdb:2VUF|rcsb pdb:2XSI|rcsb pdb:2XVQ|rcsb pdb:2XVU|rcsb pdb:2XVV|rcsb pdb:2XVW|rcsb pdb:2XW0|rcsb pdb:2XW1|rcsb pdb:2YDF|rcsb pdb:3A73|rcsb pdb:3B9L|rcsb pdb:3B9M|rcsb pdb:3CX9|rcsb pdb:3JQZ|rcsb pdb:3JRY|rcsb pdb:3LU6|rcsb pdb:4HGM|rcsb pdb:4IW1|rcsb pdb:4IW2|rcsb pdb:4K2C|rcsb pdb:4K71|rcsb pdb:4L8U|rcsb pdb:4L9K|rcsb pdb:4L9Q|rcsb pdb:4LA0|rcsb pdb:4LB2|rcsb pdb:4LB9|rcsb pdb:4N0F|rcsb pdb:4N0U|rcsb pdb:4S1Y|rcsb pdb:4Z69|rcsb pdb:5FUO|rcsb pdb:5GIX|rcsb pdb:5GIY|rcsb pdb:5ID7|rcsb pdb:5IFO|rcsb pdb:5IJF|rcsb pdb:5UJB|rcsb pdb:5VNW|rcsb pdb:5X52|rcsb pdb:5YB1|rcsb pdb:5YOQ|rcsb pdb:5Z0B|rcsb pdb:6A7P|rcsb pdb:6EZQ|rcsb pdb:6HSC|rcsb pdb:6JE7|rcsb pdb:6L4K|rcsb pdb:6M4R|rcsb pdb:3LU7|rcsb pdb:3LU8|rcsb pdb:3SQJ|rcsb pdb:3TDL|rcsb pdb:3UIV|rcsb pdb:4BKE|rcsb pdb:4E99|rcsb pdb:4EMX|rcsb pdb:4G03|rcsb pdb:4G04|rcsb pdb:4HGK|rcsb pdb:6M58|rcsb pdb:6M5D|rcsb pdb:6M5E|rcsb pdb:6QIO|rcsb pdb:6QIP|rcsb pdb:6R7S|refseq:NP_000468.1|dip:DIP-29902N	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:kjtn5mBsCZz/NRkcyW5k3ZWeJBU9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02675	intact:EBI-2679332	intact:EBI-1034445|uniprotkb:A0JLR9|uniprotkb:Q32Q65|uniprotkb:Q3KPF2|uniprotkb:B2R7G3|ensembl:ENSP00000306099	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:fibb_human(display_long)|uniprotkb:FGB(gene name)|psi-mi:FGB(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001171670.1|refseq:NP_005132.2|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0042730"(fibrinolysis)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051087"(chaperone binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|interpro:IPR037580|mint:P02675|rcsb pdb:1FZA|rcsb pdb:1FZB|rcsb pdb:1FZC|rcsb pdb:1FZE|rcsb pdb:1FZF|rcsb pdb:1FZG|rcsb pdb:1LT9|rcsb pdb:1LTJ|rcsb pdb:1N86|rcsb pdb:1N8E|rcsb pdb:1RE3|rcsb pdb:1RE4|rcsb pdb:1RF0|rcsb pdb:1RF1|rcsb pdb:2A45|rcsb pdb:2FFD|rcsb pdb:2H43|rcsb pdb:2HLO|rcsb pdb:2HOD|rcsb pdb:2HPC|rcsb pdb:2OYH|rcsb pdb:2OYI|rcsb pdb:2Q9I|rcsb pdb:2XNX|rcsb pdb:2XNY|rcsb pdb:2Z4E|rcsb pdb:3BVH|rcsb pdb:3E1I|rcsb pdb:3GHG|rcsb pdb:3H32|rcsb pdb:3HUS|rcsb pdb:6ATZ|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-114608|reactome:R-HSA-1236974|reactome:R-HSA-140875|reactome:R-HSA-166058|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5674135|reactome:R-HSA-5686938|reactome:R-HSA-6802946|ensembl:ENSG00000171564(gene)|ensembl:ENST00000302068(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-6802952|reactome:R-HSA-6802948|dip:DIP-385N	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:cbcOBnZB/W/Y7eE/IxM2HfZHpK49606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q6PJF2	intact:EBI-2679332	intact:EBI-6677217	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:q6pjf2_human(display_long)|uniprotkb:IGK@(gene name)|psi-mi:IGK@(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:1DN0|rcsb pdb:1QLR|rcsb pdb:3EYF|rcsb pdb:3EYO|interpro:IPR036179|go:"GO:0016020"(membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR013106(Immunoglobulin V-set)|rcsb pdb:2AGJ	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:t1UpDY1KOnN8lS3VjmRVzalCCuE9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:B7Z556	intact:EBI-2679332	intact:EBI-6677415	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:b7z556_human(display_long)|uniprotkb:Fetuin-A(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|interpro:IPR025760|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR001363(Proteinase inhibitor I25C, fetuin, conserved site)	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:/vxKrGTKIxrPmORDcKT3CiorUE49606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P01705	intact:EBI-2679332	intact:EBI-6677203|uniprotkb:A0A075B6J5|ensembl:ENSP00000374841	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:lv223_human(display_long)|uniprotkb:IGLV2-23(gene name)|psi-mi:IGLV2-23(display_short)|uniprotkb:Ig lambda chain V-II region NEI(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-5690714|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|reactome:R-HSA-983695|ensembl:ENSG00000211660(gene)|ensembl:ENST00000390306(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0019814"(immunoglobulin complex)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:FzGXXlzNF4kvotCBkpajLDPd37Q9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P04196	intact:EBI-2679332	intact:EBI-3915012|uniprotkb:B9EK35|uniprotkb:D3DNU7|ensembl:ENSP00000232003	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:hrg_human(display_long)|uniprotkb:HRG(gene name)|psi-mi:HRG(display_short)|uniprotkb:Histidine-proline-rich glycoprotein(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000403.1|ensembl:ENSG00000113905(gene)|ensembl:ENST00000232003(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002839"(positive regulation of immune response to tumor cell)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015886"(heme transport)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0020037"(heme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0036019"(endolysosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:2000504"(positive regulation of blood vessel remodeling)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|mint:P04196|reactome:R-HSA-114608|reactome:R-HSA-75205|go:"GO:0043254"(regulation of protein-containing complex assembly)|dip:DIP-47264N	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:o/MnMkd+IKLRtprrFoOapUuoVEs9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02654	intact:EBI-2679332	intact:EBI-1220105|uniprotkb:Q6IB97|uniprotkb:B2R526|ensembl:ENSP00000465356|ensembl:ENSP00000468029|ensembl:ENSP00000468276	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:apoc1_human(display_long)|uniprotkb:APOC1(gene name)|psi-mi:APOC1(display_short)|uniprotkb:Apolipoprotein C1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001307994.1|refseq:NP_001307995.1|refseq:NP_001636.1|ensembl:ENSG00000130208(gene)|ensembl:ENST00000588750(transcript)|ensembl:ENST00000588802(transcript)|ensembl:ENST00000592535(transcript)|go:"GO:0004859"(phospholipase inhibitor activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010900"(negative regulation of phosphatidylcholine catabolic process)|go:"GO:0010916"(negative regulation of very-low-density lipoprotein particle clearance)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0032375"(negative regulation of cholesterol transport)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034369"(plasma lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0034447"(very-low-density lipoprotein particle clearance)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042627"(chylomicron)|go:"GO:0045833"(negative regulation of lipid metabolic process)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|interpro:IPR006781(Apolipoprotein C-I)|interpro:IPR043081|rcsb pdb:1ALE|rcsb pdb:1ALF|rcsb pdb:1IOJ|rcsb pdb:1OPP|rcsb pdb:6DVU|rcsb pdb:6DXR|rcsb pdb:6DZ6|rcsb pdb:6NF3|reactome:R-HSA-8866423|reactome:R-HSA-8964046|reactome:R-HSA-9029569|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:drINJ8xVRjctp7oXvnAj2n3wlwM9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P35858	intact:EBI-2679332	intact:EBI-6677465|ensembl:ENSP00000215539|uniprotkb:B4DZY8|uniprotkb:E9PGU3	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:als_human(display_long)|uniprotkb:IGFALS(gene name)|psi-mi:IGFALS(display_short)|uniprotkb:ALS(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000099769(gene)|ensembl:ENST00000215539(transcript)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-381426|refseq:NP_001139478.1|refseq:NP_004961.1	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:xjgJ54UxwS5DwnuMgn6A8XxjvsY9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q07866	intact:EBI-2679332	intact:EBI-721019|uniprotkb:F8VTM4|uniprotkb:Q7RTQ3|uniprotkb:Q86V77|uniprotkb:Q86V78|uniprotkb:Q86V79|uniprotkb:Q7RTM2|uniprotkb:Q7RTM3|uniprotkb:Q7RTM5|uniprotkb:Q7RTP9|uniprotkb:Q7RTQ5|uniprotkb:Q7RTQ6|uniprotkb:Q86SF5|uniprotkb:Q86TF5|uniprotkb:Q86V74|uniprotkb:Q86V75|uniprotkb:Q86V76|uniprotkb:Q96H62|uniprotkb:A6NF62|intact:EBI-28976313|ensembl:ENSP00000341154	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:klc1_human(display_long)|uniprotkb:KLC1(gene name)|psi-mi:KLC1(display_short)|uniprotkb:KLC(gene name synonym)|uniprotkb:KNS2(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001123579.1|refseq:NP_005543.2|refseq:NP_891553.2|ensembl:ENST00000452929|ensembl:ENSP00000414982|ensembl:ENST00000553286|ensembl:ENSP00000452487|ensembl:ENST00000246489|ensembl:ENSP00000246489|ensembl:ENST00000334553|ensembl:ENST00000554228|ensembl:ENSP00000450616|ensembl:ENST00000557450|ensembl:ENSP00000450648|ensembl:ENST00000634686|ensembl:ENSP00000488938|ensembl:ENSP00000334523|ensembl:ENST00000347839|ensembl:ENSP00000334618|ensembl:ENSP00000341154|ensembl:ENST00000389744|ensembl:ENSP00000374394|dip:DIP-40371N|ensembl:ENSG00000126214(gene)|ensembl:ENST00000348520(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035617"(stress granule disassembly)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|mint:Q07866|rcsb pdb:3NF1|rcsb pdb:5OJ8|reactome:R-HSA-2132295|reactome:R-HSA-5625970|reactome:R-HSA-6811434|reactome:R-HSA-983189|go:"GO:0030426"(growth cone)	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:T7SJbB/PScRqj74O/NH4q1KU0YM9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q96J84	intact:EBI-2679332	intact:EBI-3988456|ensembl:ENSP00000352138|uniprotkb:Q5W0F8|uniprotkb:Q5XKC6|uniprotkb:Q7Z696|uniprotkb:Q7Z7N8|uniprotkb:Q8TB15|uniprotkb:Q9H9N1|uniprotkb:Q9NVA5	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:kirr1_human(display_long)|uniprotkb:KIRREL1(gene name)|psi-mi:KIRREL1(display_short)|uniprotkb:KIRREL(gene name synonym)|uniprotkb:Kin of irregular chiasm-like protein 1(gene name synonym)|uniprotkb:NEPH1(gene name synonym)|uniprotkb:Nephrin-like protein 1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001273278.1|ensembl:ENSG00000183853(gene)|ensembl:ENST00000359209(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0017022"(myosin binding)|go:"GO:0031253"(cell projection membrane)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|refseq:NP_060710.3|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-373753|go:"GO:0098609"(cell-cell adhesion)|refseq:XP_005245362.1	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:AZjf1PpCzbkuNJngJUPYa7bWYAo9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P00736	intact:EBI-2679332	intact:EBI-3926504|uniprotkb:Q8J012|uniprotkb:Q68D77|uniprotkb:A6NJQ8	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:c1r_human(display_long)|uniprotkb:C1R(gene name)|psi-mi:C1R(display_short)|uniprotkb:Complement component 1 subcomponent r(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR035914|interpro:IPR035976|rcsb pdb:6F1C|rcsb pdb:6F1D|rcsb pdb:6F1H|refseq:NP_001724.3|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR018097|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR000436(Sushi/SCR/CCP)|rcsb pdb:1APQ|rcsb pdb:1GPZ|rcsb pdb:1MD7|rcsb pdb:1MD8|rcsb pdb:2QY0|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0031638"(zymogen activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR033116|rcsb pdb:6F39|interpro:IPR000742(EGF-like, type 3)|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|interpro:IPR035707|interpro:IPR043504	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:7E+ASC6Hv3CoXdwfWEMwCtYALbw9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P01023	intact:EBI-2679332	intact:EBI-640741|uniprotkb:Q13677|uniprotkb:Q59F47|uniprotkb:Q5QTS0|uniprotkb:Q68DN2|uniprotkb:Q6PIY3|uniprotkb:Q6PN97|ensembl:ENSP00000323929	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:a2mg_human(display_long)|uniprotkb:CPAMD5(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5(gene name synonym)|uniprotkb:A2M(gene name)|psi-mi:A2M(display_short)|uniprotkb:FWP007(orf name)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000005.2|refseq:NP_001334352.1|refseq:NP_001334353.1|refseq:NP_001334354.1|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR010916(TonB box, conserved site)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR019742|interpro:IPR036595|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813|mint:P01023|rcsb pdb:1BV8|rcsb pdb:2P9R|rcsb pdb:4ACQ|rcsb pdb:6TAV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-1474228|reactome:R-HSA-8963896|ensembl:ENSG00000175899(gene)|ensembl:ENST00000318602(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|dip:DIP-1118N	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:FClLRDrtOWUx0eBBCUfAocx0Q+49606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P13671	intact:EBI-2679332	intact:EBI-1753221|ensembl:ENSP00000263413|ensembl:ENSP00000338861	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:co6_human(display_long)|uniprotkb:C6(gene name)|psi-mi:C6(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000056.2|refseq:NP_001108603.2|ensembl:ENSG00000039537(gene)|ensembl:ENST00000263413(transcript)|ensembl:ENST00000337836(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0019835"(cytolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR035976|interpro:IPR036055|interpro:IPR036383|rcsb pdb:3T5O|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:GfycGXFpIoDx8sLZwxVYVMaJp4g9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02671	intact:EBI-2679332	intact:EBI-348571|ensembl:ENSP00000498441|uniprotkb:Q9BX62|uniprotkb:Q9UCH2|uniprotkb:A8K3E4|uniprotkb:Q4QQH7|uniprotkb:D3DP14|uniprotkb:D3DP15	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:fiba_human(display_long)|uniprotkb:FGA(gene name)|psi-mi:FGA(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000499.1|refseq:NP_068657.1|ensembl:ENSG00000171560(gene)|ensembl:ENST00000651975(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000261"(negative regulation of blood coagulation, common pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072377"(blood coagulation, common pathway)|interpro:IPR021996|interpro:IPR036056|interpro:IPR037579|mint:P02671|rcsb pdb:1BBR|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1DM4|rcsb pdb:1FPH|rcsb pdb:1FZA|rcsb pdb:1FZB|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|rcsb pdb:1FZC|rcsb pdb:1FZD|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0042730"(fibrinolysis)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1FZF|rcsb pdb:1FZG|rcsb pdb:1LT9|rcsb pdb:1LTJ|rcsb pdb:1N86|rcsb pdb:1N8E|rcsb pdb:1RE3|rcsb pdb:1RE4|rcsb pdb:1RF0|rcsb pdb:1RF1|rcsb pdb:1YCP|rcsb pdb:2A45|rcsb pdb:2FFD|rcsb pdb:2H43|rcsb pdb:2HLO|rcsb pdb:2HOD|rcsb pdb:2HPC|rcsb pdb:2OYH|rcsb pdb:2OYI|rcsb pdb:2Q9I|rcsb pdb:2XNX|rcsb pdb:2XNY|rcsb pdb:2Z4E|rcsb pdb:3AT0|rcsb pdb:1FZE|rcsb pdb:3BVH|rcsb pdb:3E1I|rcsb pdb:3GHG|rcsb pdb:3H32|rcsb pdb:3HUS|rcsb pdb:4F27|rcsb pdb:5CFA|reactome:R-HSA-114608|reactome:R-HSA-1236974|reactome:R-HSA-5674135|reactome:R-HSA-140875|reactome:R-HSA-166058|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-5686938|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-977225|dip:DIP-29643N	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:khlQGVpd+6qZLTrsT9KxlxgjMR09606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P0CG05	intact:EBI-2679332	intact:EBI-6151637|uniprotkb:P80423|uniprotkb:A0M8Q4|uniprotkb:P0DOY2|uniprotkb:A0A075B6K9	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:iglc2_human(display_long)|uniprotkb:IGLC2(gene name)|psi-mi:IGLC2(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-2029481|reactome:R-HSA-2029482|go:"GO:0004252"(serine-type endopeptidase activity)|rcsb pdb:5IQ7|rcsb pdb:5IQ9|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|rcsb pdb:4LLQ|rcsb pdb:4O58|rcsb pdb:4O5I|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0045087"(innate immune response)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:1JVK|rcsb pdb:1LIL|rcsb pdb:1ZVO|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:3C2A|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4EOW|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-983695|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0050776"(regulation of immune response)|rcsb pdb:4LLU|rcsb pdb:4LLW|rcsb pdb:4LLY|reactome:R-HSA-5690714|rcsb pdb:6DE7|ensembl:ENST00000390323|ensembl:ENSP00000374856|ensembl:ENSG00000211677|reactome:R-HSA-202733|reactome:R-HSA-977606|go:"GO:0050900"(leukocyte migration)|go:"GO:0030449"(regulation of complement activation)|interpro:IPR036179	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:Nu+YqoiJBEpFp8ZpCoVts4PgqZM9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02766	intact:EBI-2679332	intact:EBI-711909|ensembl:ENSP00000237014|ensembl:ENSP00000497927|uniprotkb:Q6IB96|uniprotkb:Q9UBZ6|uniprotkb:Q9UCM9|uniprotkb:Q549C7	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:tthy_human(display_long)|uniprotkb:Prealbumin(gene name synonym)|uniprotkb:TBPA(gene name synonym)|uniprotkb:ATTR(gene name synonym)|uniprotkb:TTR(gene name)|psi-mi:TTR(display_short)|uniprotkb:PALB(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:3GLZ|rcsb pdb:3GPS|rcsb pdb:3GRB|rcsb pdb:3GRG|rcsb pdb:3GS0|rcsb pdb:3GS4|rcsb pdb:3GS7|rcsb pdb:3HJ0|rcsb pdb:3I9A|rcsb pdb:3I9I|rcsb pdb:3I9P|rcsb pdb:3IMR|rcsb pdb:3IMS|rcsb pdb:3IMT|rcsb pdb:3IMU|rcsb pdb:3IMV|rcsb pdb:3IMW|rcsb pdb:3IPB|rcsb pdb:3IPE|rcsb pdb:3KGS|rcsb pdb:3KGT|rcsb pdb:3KGU|rcsb pdb:3M1O|rcsb pdb:3NEE|rcsb pdb:3NEO|rcsb pdb:3NES|rcsb pdb:3NEX|rcsb pdb:3NG5|rcsb pdb:3OZK|rcsb pdb:3OZL|rcsb pdb:3FCB|rcsb pdb:3P3R|rcsb pdb:3P3S|rcsb pdb:3P3T|rcsb pdb:3P3U|rcsb pdb:3SSG|rcsb pdb:3TCT|rcsb pdb:3TFB|rcsb pdb:3U2I|rcsb pdb:3U2J|rcsb pdb:3W3B|rcsb pdb:4ABQ|rcsb pdb:4ABU|rcsb pdb:4ABV|rcsb pdb:4ABW|rcsb pdb:4AC2|rcsb pdb:4AC4|rcsb pdb:4ACT|rcsb pdb:4ANK|rcsb pdb:4D7B|rcsb pdb:4DER|rcsb pdb:4DES|rcsb pdb:4DET|rcsb pdb:4DEU|rcsb pdb:4DEW|rcsb pdb:4FI6|rcsb pdb:4FI7|rcsb pdb:4FI8|rcsb pdb:4HIQ|rcsb pdb:4HIS|rcsb pdb:4HJS|rcsb pdb:4HJT|rcsb pdb:4HJU|rcsb pdb:4I85|rcsb pdb:4I87|rcsb pdb:4IIZ|rcsb pdb:4IK6|rcsb pdb:4IK7|rcsb pdb:4IKI|rcsb pdb:4IKJ|rcsb pdb:4IKK|rcsb pdb:4IKL|rcsb pdb:4KY2|rcsb pdb:4L1S|rcsb pdb:4L1T|rcsb pdb:4MAS|rcsb pdb:4MRB|rcsb pdb:4MRC|rcsb pdb:4N85|rcsb pdb:4N86|rcsb pdb:4N87|rcsb pdb:4PM1|rcsb pdb:4PME|rcsb pdb:4PMF|rcsb pdb:4PVL|rcsb pdb:4PVM|rcsb pdb:4PVN|rcsb pdb:4I89|rcsb pdb:4PWE|rcsb pdb:4PWF|rcsb pdb:4PWG|rcsb pdb:4TLK|rcsb pdb:4TLS|rcsb pdb:4TLT|rcsb pdb:4TLU|rcsb pdb:4TM9|rcsb pdb:4TNE|rcsb pdb:4PWH|rcsb pdb:4TNF|rcsb pdb:4TNG|rcsb pdb:4TQ8|rcsb pdb:4TQH|rcsb pdb:4TQI|rcsb pdb:4TQP|rcsb pdb:4PWI|rcsb pdb:4PWJ|rcsb pdb:4PWK|rcsb pdb:4QRF|rcsb pdb:4WNJ|rcsb pdb:4WNS|rcsb pdb:4QXV|rcsb pdb:4QYA|rcsb pdb:4WO0|rcsb pdb:4TKW|rcsb pdb:4TL4|rcsb pdb:4TL5|rcsb pdb:4Y9B|rcsb pdb:4Y9C|rcsb pdb:4Y9E|rcsb pdb:4Y9F|rcsb pdb:4Y9G|rcsb pdb:4YDM|rcsb pdb:4YDN|rcsb pdb:5A6I|rcsb pdb:5AKS|rcsb pdb:5AKT|rcsb pdb:5AKV|rcsb pdb:5AL0|rcsb pdb:5AYT|rcsb pdb:5BOJ|rcsb pdb:5CLX|rcsb pdb:5CLY|rcsb pdb:5CLZ|rcsb pdb:5CM1|rcsb pdb:5AL8|rcsb pdb:5CN3|rcsb pdb:5CNH|rcsb pdb:5CR1|rcsb pdb:5DEJ|rcsb pdb:5DWP|rcsb pdb:5E23|rcsb pdb:5E4A|rcsb pdb:5E4O|rcsb pdb:5EN3|rcsb pdb:5EZP|rcsb pdb:5FO2|rcsb pdb:5FW6|rcsb pdb:5FW7|rcsb pdb:5FW8|rcsb pdb:5H0V|rcsb pdb:5H0W|rcsb pdb:5H0X|rcsb pdb:5H0Y|rcsb pdb:5H0Z|rcsb pdb:5HJG|rcsb pdb:5IHH|rcsb pdb:5JID|rcsb pdb:5JIM|rcsb pdb:5JIQ|rcsb pdb:5K1J|rcsb pdb:5K1N|rcsb pdb:5L4F|rcsb pdb:5L4I|rcsb pdb:5L4M|rcsb pdb:5LLL|rcsb pdb:5LLV|rcsb pdb:5N5Q|rcsb pdb:5N62|rcsb pdb:5N7C|rcsb pdb:5NFE|rcsb pdb:5NFW|rcsb pdb:5OQ0|rcsb pdb:5TTR|rcsb pdb:5TZL|rcsb pdb:5U48|rcsb pdb:5U49|rcsb pdb:5U4A|rcsb pdb:5U4B|rcsb pdb:5U4C|rcsb pdb:5U4D|rcsb pdb:5U4E|rcsb pdb:5U4F|rcsb pdb:5U4G|rcsb pdb:6D0W|rcsb pdb:6E6Z|rcsb pdb:6E70|rcsb pdb:6E71|rcsb pdb:5L4J|rcsb pdb:6E72|rcsb pdb:6E73|rcsb pdb:6E74|rcsb pdb:6E75|rcsb pdb:6E76|rcsb pdb:6E77|rcsb pdb:6E78|rcsb pdb:6EP1|rcsb pdb:6FFT|rcsb pdb:6FWD|rcsb pdb:6FXU|rcsb pdb:6FZL|rcsb pdb:6GR7|rcsb pdb:6GRP|rcsb pdb:6IMX|rcsb pdb:6IMY|rcsb pdb:6KGB|rcsb pdb:6R66|rcsb pdb:6R67|rcsb pdb:6R68|rcsb pdb:6R6I|rcsb pdb:6SDZ|rcsb pdb:6SUG|rcsb pdb:6SUH|rcsb pdb:6TI9|rcsb pdb:6TJN|rcsb pdb:6TXV|rcsb pdb:6TXW|rcsb pdb:6U0Q|rcsb pdb:6XTK|rcsb pdb:7ACU|reactome:R-HSA-2453864|reactome:R-HSA-2453902|reactome:R-HSA-3000171|reactome:R-HSA-6798695|reactome:R-HSA-975634|reactome:R-HSA-977225|ensembl:ENST00000237014(transcript)|ensembl:ENST00000649620(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006144"(purine nucleobase metabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:0070327"(thyroid hormone transport)|interpro:IPR000895(Transthyretin)|interpro:IPR023416|interpro:IPR023418|interpro:IPR023419|interpro:IPR030178|interpro:IPR036817|mint:P02766|rcsb pdb:1BM7|rcsb pdb:1BMZ|rcsb pdb:1BZ8|rcsb pdb:1BZD|rcsb pdb:1BZE|rcsb pdb:1DVQ|rcsb pdb:1DVS|rcsb pdb:1DVT|rcsb pdb:1DVU|rcsb pdb:1DVX|rcsb pdb:1DVY|rcsb pdb:1DVZ|rcsb pdb:1E3F|rcsb pdb:1E4H|ensembl:ENSG00000118271(gene)|rcsb pdb:1E5A|rcsb pdb:1ETA|rcsb pdb:1ETB|rcsb pdb:1F41|rcsb pdb:1F64|rcsb pdb:1F86|rcsb pdb:1FH2|rcsb pdb:1FHN|rcsb pdb:1G1O|rcsb pdb:1GKO|rcsb pdb:1ICT|rcsb pdb:1III|rcsb pdb:1IIK|rcsb pdb:1IJN|rcsb pdb:1QAB|rcsb pdb:1QWH|rcsb pdb:1RLB|rcsb pdb:1SOK|rcsb pdb:1SOQ|rcsb pdb:1THA|rcsb pdb:1THC|rcsb pdb:1TLM|rcsb pdb:1TSH|rcsb pdb:1TT6|rcsb pdb:1TTA|rcsb pdb:1TTB|rcsb pdb:2F7I|rcsb pdb:2F8I|rcsb pdb:2FBR|rcsb pdb:2FLM|rcsb pdb:1TTC|rcsb pdb:2G3X|rcsb pdb:2G3Z|rcsb pdb:2G4E|rcsb pdb:2G4G|rcsb pdb:2G5U|rcsb pdb:2G9K|rcsb pdb:2GAB|rcsb pdb:2H4E|rcsb pdb:2M5N|rcsb pdb:2NBO|rcsb pdb:2NBP|rcsb pdb:2NOY|rcsb pdb:2PAB|rcsb pdb:2QEL|rcsb pdb:2QGB|rcsb pdb:2QGC|rcsb pdb:2QGD|rcsb pdb:1TTR|rcsb pdb:1TYR|rcsb pdb:1TZ8|rcsb pdb:1U21|rcsb pdb:2QGE|rcsb pdb:2ROX|rcsb pdb:2ROY|rcsb pdb:2TRH|rcsb pdb:2TRY|rcsb pdb:2WQA|rcsb pdb:3A4D|rcsb pdb:3A4E|rcsb pdb:3A4F|rcsb pdb:3B56|rcsb pdb:3BSZ|rcsb pdb:3BT0|rcsb pdb:3CBR|rcsb pdb:3CFM|rcsb pdb:3CFN|rcsb pdb:1X7S|rcsb pdb:1X7T|rcsb pdb:3CFQ|rcsb pdb:3CFT|rcsb pdb:3CN0|rcsb pdb:3CN1|rcsb pdb:3CN2|rcsb pdb:3CN3|rcsb pdb:3CN4|rcsb pdb:3CXF|rcsb pdb:3D2T|rcsb pdb:3D7P|rcsb pdb:3DGD|rcsb pdb:3DID|rcsb pdb:1Y1D|rcsb pdb:1Z7J|rcsb pdb:1ZCR|rcsb pdb:1ZD6|rcsb pdb:2B14|rcsb pdb:2B15|rcsb pdb:2B16|rcsb pdb:2B77|rcsb pdb:2B9A|rcsb pdb:3DJR|rcsb pdb:3DJS|rcsb pdb:3DJT|rcsb pdb:3DJZ|rcsb pdb:3DK0|rcsb pdb:3DK2|rcsb pdb:3DO4|rcsb pdb:3ESN|rcsb pdb:3ESO|rcsb pdb:3ESP|rcsb pdb:3FC8|refseq:NP_000362.1|dip:DIP-1083N	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:VwPs2NgicC89f7Ehgf4d6uE9DuU9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:A0M8Q6	intact:EBI-2679332	intact:EBI-6677450|uniprotkb:A0A075B6L1	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:iglc7_human(display_long)|uniprotkb:IGLC7(gene name)|psi-mi:IGLC7(display_short)|uniprotkb:Ig lambda-7 chain C region(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	reactome:R-HSA-5690714|reactome:R-HSA-202733|reactome:R-HSA-166663|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-983695|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|reactome:R-HSA-977606|interpro:IPR036179|reactome:R-HSA-9664323|reactome:R-HSA-9664422	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:JCCwWWPar7MJo8W5z0wjO/IR6mw9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q6N030	intact:EBI-2679332	intact:EBI-6677424	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:q6n030_human(display_long)|uniprotkb:DKFZp686I15212(gene name)|psi-mi:DKFZp686I15212(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:2NY3|go:"GO:0016020"(membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR013106(Immunoglobulin V-set)|rcsb pdb:2NY1|rcsb pdb:2NY6|interpro:IPR036179	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:+snXRtR7l8gkznx04PJ/NsYobT09606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:B9A064	intact:EBI-2679332	intact:EBI-6677229|ensembl:ENSP00000431254	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:igll5_human(display_long)|uniprotkb:IGLL5(gene name)|psi-mi:IGLL5(display_short)|uniprotkb:G lambda-1(gene name synonym)|uniprotkb:Germline immunoglobulin lambda 1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000254709(gene)|ensembl:ENST00000526893(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|refseq:NP_001171597.1	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:m8O2m7mjoNUlzbBeF9kOhSYTgOQ9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02652	intact:EBI-2679332	intact:EBI-1171525|uniprotkb:B2R524|ensembl:ENSP00000356969	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:apoa2_human(display_long)|uniprotkb:APOA2(gene name)|psi-mi:APOA2(display_short)|uniprotkb:Apolipoprotein A2(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001634.1|ensembl:ENSG00000158874(gene)|ensembl:ENST00000367990(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0009749"(response to glucose)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0015485"(cholesterol binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0018206"(peptidyl-methionine modification)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032375"(negative regulation of cholesterol transport)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034370"(triglyceride-rich lipoprotein particle remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0046340"(diacylglycerol catabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060621"(negative regulation of cholesterol import)|go:"GO:0060695"(negative regulation of cholesterol transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070653"(high-density lipoprotein particle receptor binding)|go:"GO:0072562"(blood microparticle)|go:"GO:0120020"(cholesterol transfer activity)|interpro:IPR006801("Apolipoprotein A-II (ApoA-II)")|interpro:IPR036172|mint:P02652|reactome:R-HSA-1989781|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963901|reactome:R-HSA-975634	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:uTkwkAwBXAMjDt6PkLhEazATi4g9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P04004	intact:EBI-2679332	intact:EBI-1036653|uniprotkb:P01141|uniprotkb:Q9BSH7|uniprotkb:B2R7G0|ensembl:ENSP00000226218	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:vtnc_human(display_long)|uniprotkb:VTN(gene name)|psi-mi:VTN(display_short)|uniprotkb:Serum-spreading factor(gene name synonym)|uniprotkb:V75(gene name synonym)|uniprotkb:S-protein(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000629.3|ensembl:ENSG00000109072(gene)|ensembl:ENST00000226218(transcript)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061302"(smooth muscle cell-matrix adhesion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0072562"(blood microparticle)|go:"GO:0090303"(positive regulation of wound healing)|interpro:IPR000585(Hemopexin)|interpro:IPR001212(Somatomedin B)|interpro:IPR018486|interpro:IPR018487|interpro:IPR020436|interpro:IPR036024|interpro:IPR036375|mint:P04004|rcsb pdb:1OC0|rcsb pdb:1S4G|rcsb pdb:1SSU|rcsb pdb:2JQ8|rcsb pdb:3BT1|rcsb pdb:3BT2|rcsb pdb:4K24|rcsb pdb:6O5E|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-977606|dip:DIP-36566N	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:07qxfQS6kbUZGwPyNj8/LTetT6I9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P51530	intact:EBI-2679332	intact:EBI-6677369|ensembl:ENSP00000351185|uniprotkb:Q2NKM1|uniprotkb:Q5TC49|uniprotkb:Q5TC50|uniprotkb:Q6P455|uniprotkb:Q6PI80|uniprotkb:Q7Z6H9|uniprotkb:Q8N346	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:dna2_human(display_long)|uniprotkb:DNA2(gene name)|psi-mi:DNA2(display_short)|uniprotkb:DNA2L(gene name synonym)|uniprotkb:KIAA0083(gene name synonym)|uniprotkb:DNA replication ATP-dependent helicase-like homolog(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000138346(gene)|ensembl:ENST00000358410(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006260"(DNA replication)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0016890"(site-specific endodeoxyribonuclease activity, specific for altered base)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0033567"(DNA replication, Okazaki fragment processing)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043137"(DNA replication, removal of RNA primer)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0071932"(replication fork reversal)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0090656"(t-circle formation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR014808(DNA replication factor Dna2)|interpro:IPR026851|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|rcsb pdb:5EAY|reactome:R-HSA-174437|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69166|reactome:R-HSA-69473|refseq:NP_001073918.2	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:ftL7EgRB3WfppiSav6gChBIOMZs9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q9P0P1	intact:EBI-2679332	intact:EBI-6677110	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:q9p0p1_human(display_long)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	-	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:jAxWDUEJq8ylu4SG7eouaCvDXzI9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q96CV9	intact:EBI-2679332	intact:EBI-748974|uniprotkb:Q5T672|uniprotkb:Q5T673|uniprotkb:Q5T674|uniprotkb:Q5T675|uniprotkb:Q7LDL9|uniprotkb:Q8N562|uniprotkb:Q9UET9|uniprotkb:Q9UEV4|uniprotkb:Q9Y218|uniprotkb:B3KP00|uniprotkb:D3DRS4|uniprotkb:D3DRS8|ensembl:ENSP00000263036|ensembl:ENSP00000368021|ensembl:ENSP00000368022|ensembl:ENSP00000368032	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:optn_human(display_long)|uniprotkb:HYPL(gene name synonym)|uniprotkb:Optic neuropathy-inducing protein(gene name synonym)|uniprotkb:E3-14.7K-interacting protein(gene name synonym)|uniprotkb:FIP-2(gene name synonym)|uniprotkb:Huntingtin-interacting protein L(gene name synonym)|uniprotkb:Huntingtin yeast partner L(gene name synonym)|uniprotkb:NEMO-related protein(gene name synonym)|uniprotkb:Transcription factor IIIA-interacting protein(gene name synonym)|uniprotkb:OPTN(gene name)|psi-mi:OPTN(display_short)|uniprotkb:FIP2(gene name synonym)|uniprotkb:GLC1E(gene name synonym)|uniprotkb:NRP(gene name synonym)|uniprotkb:HIP7(gene name synonym)|uniprotkb:Huntingtin-interacting protein 7(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001008212.1|refseq:NP_001008213.1|refseq:NP_001008214.1|refseq:NP_068815.2|ensembl:ENSG00000123240(gene)|ensembl:ENST00000263036(transcript)|ensembl:ENST00000378747(transcript)|ensembl:ENST00000378748(transcript)|ensembl:ENST00000378757(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR021063|interpro:IPR032419|interpro:IPR032939|interpro:IPR034735|mint:Q96CV9|rcsb pdb:2LO4|rcsb pdb:2LUE|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:5AAZ|rcsb pdb:5B83|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:7CZM|reactome:R-HSA-2565942|reactome:R-HSA-8854214|dip:DIP-42001N	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:jcCTXDx1bJq3K5mgNUD73jeWeBU9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P06727	intact:EBI-2679332	intact:EBI-1222447|uniprotkb:Q14CW8|uniprotkb:Q6Q787|uniprotkb:A8MSL6|ensembl:ENSP00000350425	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:apoa4_human(display_long)|uniprotkb:APOA4(gene name)|psi-mi:APOA4(display_short)|uniprotkb:Apolipoprotein A4(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000473.2|dip:DIP-38333N|ensembl:ENSG00000110244(gene)|ensembl:ENST00000357780(transcript)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006869"(lipid transport)|go:"GO:0006982"(response to lipid hydroperoxide)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034378"(chylomicron assembly)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034445"(negative regulation of plasma lipoprotein oxidation)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065005"(protein-lipid complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0120020"(cholesterol transfer activity)|interpro:IPR000074(Apolipoprotein A1/A4/E)|rcsb pdb:3S84|reactome:R-HSA-8963888|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634|reactome:R-HSA-977225|go:"GO:0070328"(triglyceride homeostasis)	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:95b7Xlqg/plh9/R7xhLBsMXQscM9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P00738	intact:EBI-2679332	intact:EBI-1220767|uniprotkb:P00737|uniprotkb:Q0VAC4|uniprotkb:Q2PP15|uniprotkb:Q3B7J0|uniprotkb:Q6LBY9|uniprotkb:B0AZL5|uniprotkb:Q9UC67|uniprotkb:Q0VAC5|ensembl:ENSP00000348170	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:hpt_human(display_long)|uniprotkb:HP(gene name)|psi-mi:HP(display_short)|uniprotkb:Zonulin(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001119574.1|refseq:NP_005134.1|refseq:NP_001305067.1|ensembl:ENSG00000257017(gene)|ensembl:ENST00000355906(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016209"(antioxidant activity)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0031638"(zymogen activation)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071682"(endocytic vesicle lumen)|interpro:IPR008292(Haptoglobin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR035976|interpro:IPR043504|mint:P00738|rcsb pdb:4WJG|rcsb pdb:4X0L|rcsb pdb:5HU6|rcsb pdb:6TB2|reactome:R-HSA-2168880|go:"GO:0072562"(blood microparticle)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:2000296"(negative regulation of hydrogen peroxide catabolic process)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|reactome:R-HSA-6798695	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:IsI1hIXfhsW0goXPHsoADxl7V5g9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P10909	intact:EBI-2679332	intact:EBI-1104674|uniprotkb:B3KSE6|uniprotkb:P11380|uniprotkb:P11381|uniprotkb:Q5HYC1|uniprotkb:Q7Z5B9|uniprotkb:B2R9Q1|uniprotkb:Q2TU75|ensembl:ENSP00000315130|ensembl:ENSP00000385419|ensembl:ENSP00000429620	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:clus_human(display_long)|uniprotkb:CLU(gene name)|psi-mi:CLU(display_short)|uniprotkb:APOJ(gene name synonym)|uniprotkb:CLI(gene name synonym)|uniprotkb:KUB1(gene name synonym)|uniprotkb:Complement-associated protein SP-40,40(gene name synonym)|uniprotkb:Complement cytolysis inhibitor(gene name synonym)|uniprotkb:NA1/NA2(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:Testosterone-repressed prostate message 2(gene name synonym)|uniprotkb:Ku70-binding protein 1(gene name synonym)|uniprotkb:Aging-associated gene 4 protein(gene name synonym)|uniprotkb:AAG4(orf name)|uniprotkb:Sulfated glycoprotein 2(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0006629"(lipid metabolic process)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017038"(protein import)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000120885(gene)|ensembl:ENST00000316403(transcript)|ensembl:ENST00000405140(transcript)|ensembl:ENST00000523500(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002434"(immune complex clearance)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042583"(chromaffin granule)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097440"(apical dendrite)|go:"GO:0099020"(perinuclear endoplasmic reticulum lumen)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902847"(regulation of neuronal signal transduction)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1905892"(negative regulation of cellular response to thapsigargin)|go:"GO:1905895"(negative regulation of cellular response to tunicamycin)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000753(Clusterin-like)|interpro:IPR016014(Clusterin, N-terminal)|interpro:IPR016015(Clusterin, C-terminal)|interpro:IPR016016(Clusterin)|interpro:IPR033986|mint:P10909|reactome:R-HSA-114608|reactome:R-HSA-166665|reactome:R-HSA-6803157|go:"GO:0060548"(negative regulation of cell death)|reactome:R-HSA-977606|refseq:NP_001822.3|dip:DIP-37546N	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:qlCJp4zYTklC3YZNQvbLmZBiz4U9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P20851	intact:EBI-2679332	intact:EBI-6677075|uniprotkb:A5JYP8|uniprotkb:D3DT81|uniprotkb:Q5VVR0|uniprotkb:Q9BS25|ensembl:ENSP00000243611|ensembl:ENSP00000356045|ensembl:ENSP00000375790	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:c4bpb_human(display_long)|uniprotkb:C4BPB(gene name)|psi-mi:C4BPB(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_005273311.1|refseq:NP_000707.1|refseq:NP_001017364.1|refseq:NP_001017365.1|refseq:NP_001017366.1|refseq:NP_001017367.1|ensembl:ENSG00000123843(gene)|ensembl:ENST00000243611(transcript)|ensembl:ENST00000367078(transcript)|ensembl:ENST00000391923(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:1903027"(regulation of opsonization)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-977606	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:h6kTgvDfw8LUJYECvNIAC2wkM8Y9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P04003	intact:EBI-2679332	intact:EBI-978348|ensembl:ENSP00000356037|uniprotkb:Q5VVQ8	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:c4bpa_human(display_long)|uniprotkb:Proline-rich protein(gene name synonym)|uniprotkb:C4BPA(gene name)|psi-mi:C4BPA(display_short)|uniprotkb:C4BP(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000123838(gene)|ensembl:ENST00000367070(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0072562"(blood microparticle)|go:"GO:1903027"(regulation of opsonization)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|interpro:IPR040514|rcsb pdb:2A55|rcsb pdb:4B0F|rcsb pdb:5HYP|rcsb pdb:5HYT|rcsb pdb:5HYU|rcsb pdb:5HZP|rcsb pdb:5I0Q|reactome:R-HSA-977606|refseq:NP_000706.1|refseq:XP_005273308.1|refseq:XP_005273309.1	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:S0F99wuDTalS4UCuYGWbiCgWlO09606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q6GMX3	intact:EBI-2679332	intact:EBI-6677439	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:q6gmx3_human(display_long)|uniprotkb:IGL@(gene name)|psi-mi:IGL@(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0016020"(membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:yIUeMYkZHPaQ+I3P3e7+4zfPybw9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:O15270	intact:EBI-2679332	intact:EBI-766136|uniprotkb:Q16685|ensembl:ENSP00000216484	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:sptc2_human(display_long)|uniprotkb:Serine-palmitoyl-CoA transferase 2(gene name synonym)|uniprotkb:Long chain base biosynthesis protein 2(gene name synonym)|uniprotkb:SPTLC2(gene name)|psi-mi:SPTLC2(display_short)|uniprotkb:KIAA0526(gene name synonym)|uniprotkb:LCB2(gene name synonym)|uniprotkb:Long chain base biosynthesis protein 2a(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004854.1|dip:DIP-34604N|ensembl:ENSG00000100596(gene)|ensembl:ENST00000216484(transcript)|go:"GO:0004758"(serine C-palmitoyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006686"(sphingomyelin biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017059"(serine C-palmitoyltransferase complex)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0046511"(sphinganine biosynthetic process)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:1904504"(positive regulation of lipophagy)|interpro:IPR001917(Aminotransferase, class-II, pyridoxal-phosphate binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:O15270|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0I|rcsb pdb:7K0J|rcsb pdb:7K0K|rcsb pdb:7K0L|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:9Y8pOwwEej+jqblWkGS0ixnNHLo9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02656	intact:EBI-2679332	intact:EBI-1220113|uniprotkb:Q08E83|uniprotkb:Q6Q786|ensembl:ENSP00000227667	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:apoc3_human(display_long)|uniprotkb:APOC3(gene name)|psi-mi:APOC3(display_short)|uniprotkb:Apolipoprotein C3(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000031.1|ensembl:ENSG00000110245(gene)|ensembl:ENST00000227667(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010916"(negative regulation of very-low-density lipoprotein particle clearance)|go:"GO:0010987"(negative regulation of high-density lipoprotein particle clearance)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0015485"(cholesterol binding)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045833"(negative regulation of lipid metabolic process)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060621"(negative regulation of cholesterol import)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070653"(high-density lipoprotein particle receptor binding)|interpro:IPR008403(Apolipoprotein CIII)|interpro:IPR038195|mint:P02656|rcsb pdb:2JQ3|reactome:R-HSA-8963888|reactome:R-HSA-8963901|reactome:R-HSA-8964058|reactome:R-HSA-975634	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:DDj33pQWDh0i5+mwMy16Dmg6JPg9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P01024	intact:EBI-2679332	intact:EBI-905851|uniprotkb:A7E236|ensembl:ENSP00000245907	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:co3_human(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:CPAMD1(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000055.2|dip:DIP-35180N|ensembl:ENSG00000125730(gene)|ensembl:ENST00000245907(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01024|rcsb pdb:1C3D|rcsb pdb:1GHQ|rcsb pdb:1W2S|rcsb pdb:2A73|rcsb pdb:2A74|rcsb pdb:2GOX|rcsb pdb:2I07|rcsb pdb:2ICE|rcsb pdb:2ICF|rcsb pdb:2NOJ|rcsb pdb:2QKI|rcsb pdb:2WII|rcsb pdb:2WIN|rcsb pdb:2WY7|rcsb pdb:2WY8|rcsb pdb:2XQW|rcsb pdb:2XWB|rcsb pdb:2XWJ|rcsb pdb:3D5R|rcsb pdb:3D5S|rcsb pdb:3G6J|rcsb pdb:3L3O|rcsb pdb:3L5N|rcsb pdb:3NMS|rcsb pdb:3OED|rcsb pdb:3OHX|rcsb pdb:3OXU|rcsb pdb:3RJ3|rcsb pdb:3T4A|rcsb pdb:4HW5|rcsb pdb:4HWJ|rcsb pdb:4I6O|rcsb pdb:4M76|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5FO7|rcsb pdb:5FO8|rcsb pdb:5FO9|rcsb pdb:5FOA|rcsb pdb:5FOB|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:6EHG|rcsb pdb:6RMT|rcsb pdb:6RMU|rcsb pdb:6RUR|rcsb pdb:6RUV|rcsb pdb:6S0B|rcsb pdb:6YO6|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-198933|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9660826|reactome:R-HSA-977606	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:6Axa89cCPpUXFsLnd7sCurZzLYI9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02743	intact:EBI-2679332	intact:EBI-2115799|ensembl:ENSP00000255040	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:samp_human(display_long)|uniprotkb:APCS(gene name)|psi-mi:APCS(display_short)|uniprotkb:PTX2(gene name synonym)|uniprotkb:9.5S alpha-1-glycoprotein(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001630.1|dip:DIP-46911N|ensembl:ENSG00000132703(gene)|ensembl:ENST00000255040(transcript)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0006457"(protein folding)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|rcsb pdb:1GYK|rcsb pdb:1LGN|rcsb pdb:1SAC|rcsb pdb:2A3W|rcsb pdb:2A3X|rcsb pdb:2A3Y|rcsb pdb:2W08|rcsb pdb:3D5O|rcsb pdb:3KQR|rcsb pdb:4AVS|rcsb pdb:4AVT|rcsb pdb:4AVV|rcsb pdb:4AYU|reactome:R-HSA-977225	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:WOzyPFzTtaBN2E4vVhJyXLGNLcY9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:A6NMZ7	intact:EBI-2679332	intact:EBI-6677488|ensembl:ENSP00000351310|uniprotkb:A7DZQ0|uniprotkb:A7DZQ1|uniprotkb:A7DZQ2|uniprotkb:Q69YT0	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:co6a6_human(display_long)|uniprotkb:COL6A6(gene name)|psi-mi:COL6A6(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_016861200.1|refseq:XP_016861201.1|refseq:XP_016861202.1|refseq:XP_016861203.1|refseq:XP_016861204.1|ensembl:ENSG00000206384(gene)|ensembl:ENST00000358511(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0007155"(cell adhesion)|go:"GO:0031012"(extracellular matrix)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR036465|reactome:R-HSA-1442490|reactome:R-HSA-1650814|reactome:R-HSA-186797|reactome:R-HSA-2022090|reactome:R-HSA-216083|reactome:R-HSA-3000178|reactome:R-HSA-419037|reactome:R-HSA-8948216|refseq:XP_011510727.1|refseq:XP_011510728.1|refseq:XP_011510730.1|refseq:XP_005247178.1|refseq:NP_001096078.1	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:myofH+ZEUVu3/R/67XCrqM8z8g09606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P51884	intact:EBI-2679332	intact:EBI-725780|uniprotkb:Q96QM7|uniprotkb:B2R6R5|ensembl:ENSP00000266718	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:lum_human(display_long)|uniprotkb:SLRR2D(gene name synonym)|uniprotkb:Keratan sulfate proteoglycan lumican(gene name synonym)|uniprotkb:LUM(gene name)|psi-mi:LUM(display_short)|uniprotkb:LDC(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002336.1|ensembl:ENSG00000139329(gene)|ensembl:ENST00000266718(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005583"(fibrillar collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007601"(visual perception)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070848"(response to growth factor)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027219|interpro:IPR032675|reactome:R-HSA-2022854|reactome:R-HSA-2022857|reactome:R-HSA-216083|reactome:R-HSA-3000178|reactome:R-HSA-3656225|reactome:R-HSA-3656243|reactome:R-HSA-3656244	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:+NFnJYYdpuAtRDyyW3CZE3mKEto9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02649	intact:EBI-2679332	intact:EBI-1222467|uniprotkb:C0JYY5|uniprotkb:Q9P2S4|uniprotkb:B2RC15|ensembl:ENSP00000252486	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:apoe_human(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000032.1|refseq:NP_001289617.1|refseq:NP_001289618.1|refseq:NP_001289619.1|refseq:NP_001289620.1|dip:DIP-1120N|ensembl:ENSG00000130203(gene)|ensembl:ENST00000252486(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007616"(long-term memory)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010467"(gene expression)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010877"(lipid transport involved in lipid storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016209"(antioxidant activity)|go:"GO:0017038"(protein import)|go:"GO:0019068"(virion assembly)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034447"(very-low-density lipoprotein particle clearance)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0046907"(intracellular transport)|go:"GO:0046911"(metal chelating activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0051651"(maintenance of location in cell)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071830"(triglyceride-rich lipoprotein particle clearance)|go:"GO:0071831"(intermediate-density lipoprotein particle clearance)|go:"GO:0072562"(blood microparticle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901627"(negative regulation of postsynaptic membrane organization)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902947"(regulation of tau-protein kinase activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1902999"(negative regulation of phospholipid efflux)|go:"GO:1903001"(negative regulation of lipid transport across blood-brain barrier)|go:"GO:1903002"(positive regulation of lipid transport across blood-brain barrier)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1905855"(positive regulation of heparan sulfate binding)|go:"GO:1905860"(positive regulation of heparan sulfate proteoglycan binding)|go:"GO:1905890"(regulation of cellular response to very-low-density lipoprotein particle stimulus)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990777"(lipoprotein particle)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P02649|rcsb pdb:1B68|rcsb pdb:1BZ4|rcsb pdb:1EA8|rcsb pdb:1GS9|rcsb pdb:1H7I|rcsb pdb:1LE2|rcsb pdb:1LE4|rcsb pdb:1LPE|rcsb pdb:1NFN|rcsb pdb:1NFO|rcsb pdb:1OEF|rcsb pdb:1OEG|rcsb pdb:1OR2|rcsb pdb:1OR3|rcsb pdb:2KC3|rcsb pdb:2KNY|rcsb pdb:2L7B|rcsb pdb:6IWB|rcsb pdb:6NCN|rcsb pdb:6NCO|reactome:R-HSA-1251985|reactome:R-HSA-3000480|reactome:R-HSA-381426|reactome:R-HSA-8864260|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963901|reactome:R-HSA-8964026|reactome:R-HSA-8964058|reactome:R-HSA-9029569|reactome:R-HSA-975634|reactome:R-HSA-977225	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:vnCU03+HdGblqtALKeOTZRx5/3E9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q99645	intact:EBI-2679332	intact:EBI-6677336|ensembl:ENSP00000261172|uniprotkb:A8K3M7|uniprotkb:Q8NEJ5	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:epyc_human(display_long)|uniprotkb:EPYC(gene name)|psi-mi:EPYC(display_short)|uniprotkb:DSPG3(gene name synonym)|uniprotkb:PGLB(gene name synonym)|uniprotkb:SLRR3B(gene name synonym)|uniprotkb:Dermatan sulfate proteoglycan 3(gene name synonym)|uniprotkb:Proteoglycan-Lb(gene name synonym)|uniprotkb:Small chondroitin/dermatan sulfate proteoglycan(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000083782(gene)|ensembl:ENST00000261172(transcript)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0031012"(extracellular matrix)|go:"GO:0060348"(bone development)|go:"GO:0061975"(articular cartilage development)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027217|interpro:IPR032675|interpro:IPR043547|refseq:NP_004941.2	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:1qzc4zJzP7s4IHAGdKeYCcWtEjs9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02679	intact:EBI-2679332	intact:EBI-1034422|uniprotkb:P04469|uniprotkb:P04470|uniprotkb:Q96A14|uniprotkb:Q96KJ3|uniprotkb:A8K057|uniprotkb:Q53Y18|uniprotkb:Q9UC62|uniprotkb:Q9UC63|uniprotkb:Q9UCF3|ensembl:ENSP00000336829	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:fibg_human(display_long)|uniprotkb:FGG(gene name)|psi-mi:FGG(display_short)|uniprotkb:PRO2061(orf name)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000500.2|refseq:NP_068656.2|ensembl:ENSG00000171557(gene)|ensembl:ENST00000336098(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0009306"(protein secretion)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0036345"(platelet maturation)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR037581|mint:P02679|rcsb pdb:1DUG|rcsb pdb:1FIB|rcsb pdb:1FIC|rcsb pdb:1FID|rcsb pdb:1FZA|go:"GO:0070527"(platelet aggregation)|rcsb pdb:1FZB|rcsb pdb:1FZC|rcsb pdb:1FZE|rcsb pdb:1FZF|rcsb pdb:1FZG|rcsb pdb:1LT9|rcsb pdb:1LTJ|rcsb pdb:1N86|rcsb pdb:1N8E|rcsb pdb:1RE3|rcsb pdb:1RE4|rcsb pdb:1RF0|rcsb pdb:1RF1|rcsb pdb:2A45|rcsb pdb:2FFD|rcsb pdb:2FIB|rcsb pdb:2H43|rcsb pdb:2HLO|rcsb pdb:2HOD|rcsb pdb:2HPC|rcsb pdb:2HWL|rcsb pdb:2OYH|rcsb pdb:2OYI|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:2VR3|rcsb pdb:2XNX|rcsb pdb:2XNY|rcsb pdb:2Y7L|rcsb pdb:2Z4E|rcsb pdb:3BVH|rcsb pdb:3E1I|rcsb pdb:2Q9I|rcsb pdb:3FIB|rcsb pdb:3GHG|rcsb pdb:3H32|rcsb pdb:3HUS|rcsb pdb:4B60|reactome:R-HSA-114608|reactome:R-HSA-1236974|reactome:R-HSA-140875|reactome:R-HSA-166058|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5674135|reactome:R-HSA-5686938|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223|dip:DIP-29644N	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:QKWesyU4/fduceFtu5zq31oGhYI9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q9NRD9	intact:EBI-2679332	intact:EBI-6677285|ensembl:ENSP00000317997|ensembl:ENSP00000373689|uniprotkb:A6NH28|uniprotkb:Q14C94|uniprotkb:Q6ZMB3|uniprotkb:Q6ZR09|uniprotkb:Q9NZC1	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:duox1_human(display_long)|uniprotkb:DUOX1(gene name)|psi-mi:DUOX1(display_short)|uniprotkb:DUOX(gene name synonym)|uniprotkb:LNOX1(gene name synonym)|uniprotkb:THOX1(gene name synonym)|uniprotkb:Large NOX 1(gene name synonym)|uniprotkb:Long NOX 1(gene name synonym)|uniprotkb:NADPH thyroid oxidase 1(gene name synonym)|uniprotkb:Thyroid oxidase 1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000137857(gene)|ensembl:ENST00000321429(transcript)|ensembl:ENST00000389037(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0006952"(defense response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009986"(cell surface)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020037"(heme binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0042335"(cuticle development)|go:"GO:0042446"(hormone biosynthetic process)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0050661"(NADP binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0051591"(response to cAMP)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106293"(NADH oxidase H202-forming activity)|go:"GO:0106294"(NADPH oxidase H202-forming activity)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR010255(Haem peroxidase)|interpro:IPR011992(EF-Hand type)|interpro:IPR013112(FAD-binding 8)|interpro:IPR013121(Ferric reductase, NAD binding)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR017927|interpro:IPR017938|interpro:IPR018247|interpro:IPR019791|interpro:IPR029595|interpro:IPR034821|interpro:IPR037120|interpro:IPR039261|rcsb pdb:7D3E|rcsb pdb:7D3F|reactome:R-HSA-209968|refseq:XP_011519984.1|refseq:NP_059130.2|refseq:NP_787954.1	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:8kuQuOkttH16Rfv0TzxsVLGZQSk9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P00450	intact:EBI-2679332	intact:EBI-1220171|uniprotkb:Q14063|uniprotkb:Q2PP18|uniprotkb:Q9UKS4|ensembl:ENSP00000264613	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:ceru_human(display_long)|uniprotkb:CP(gene name)|psi-mi:CP(display_short)|uniprotkb:Ferroxidase(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000087.1|ensembl:ENSG00000047457(gene)|ensembl:ENST00000264613(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006825"(copper ion transport)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR001117(Multicopper oxidase, type 1)|interpro:IPR002355(Multicopper oxidase, copper-binding site)|interpro:IPR008972(Cupredoxin)|interpro:IPR011706(Multicopper oxidase, type 2)|interpro:IPR011707(Multicopper oxidase, type 3)|interpro:IPR033138|mint:P00450|rcsb pdb:1KCW|rcsb pdb:2J5W|rcsb pdb:4EJX|rcsb pdb:4ENZ|reactome:R-HSA-381426|reactome:R-HSA-425410|reactome:R-HSA-5619049|reactome:R-HSA-5619060|reactome:R-HSA-8957275|reactome:R-HSA-917937	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:bPuhUo8h0DvtcwLufTOOHxrl9NI9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q15166	intact:EBI-2679332	intact:EBI-6677114|ensembl:ENSP00000265627|uniprotkb:A4D1H8|uniprotkb:O75855|uniprotkb:O76060|uniprotkb:Q6IRU9|uniprotkb:Q8IX97|uniprotkb:Q9BZH9	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:pon3_human(display_long)|uniprotkb:PON3(gene name)|psi-mi:PON3(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000105852(gene)|ensembl:ENST00000265627(transcript)|go:"GO:0004063"(aryldialkylphosphatase activity)|go:"GO:0004064"(arylesterase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0010124"(phenylacetate catabolic process)|go:"GO:0018733"(3,4-dihydrocoumarin hydrolase activity)|go:"GO:0019439"(aromatic compound catabolic process)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046226"(coumarin catabolic process)|go:"GO:0046395"(carboxylic acid catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0102007"(acyl-L-homoserine-lactone lactonohydrolase activity)|go:"GO:0009636"(response to toxic substance)|interpro:IPR002640(Arylesterase)|interpro:IPR008364(Paraoxonase2)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|reactome:R-HSA-2142688|refseq:NP_000931.1	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:KzyA/Zs/1Tn8fmsUChooqHJNM3M9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P01859	intact:EBI-2679332	intact:EBI-1044662|uniprotkb:A6NE66|ensembl:ENSP00000374987|ensembl:ENSP00000480351	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:ighg2_human(display_long)|uniprotkb:IGHG2(gene name)|psi-mi:IGHG2(display_short)|uniprotkb:Ig gamma-2 chain C region(gene name synonym)|uniprotkb:Ig gamma-2 chain C region DOT(gene name synonym)|uniprotkb:Ig gamma-2 chain C region TIL(gene name synonym)|uniprotkb:Ig gamma-2 chain C region ZIE(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|rcsb pdb:4L4J|ensembl:ENSG00000211893(gene)|ensembl:ENSG00000274497(gene)|ensembl:ENST00000390545(transcript)|ensembl:ENST00000621803(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2QSC|rcsb pdb:4HAF|rcsb pdb:4HAG	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:EZkOg27Ga0FblVGpeMMQzW0s/xo9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q8IWJ2	intact:EBI-2679332	intact:EBI-1645320|uniprotkb:O15045|uniprotkb:Q4ZG46|uniprotkb:Q8TDH3|uniprotkb:Q9H2G8|uniprotkb:A6H8X8|intact:EBI-1645335|intact:EBI-28984280|ensembl:ENSP00000307939	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:gcc2_human(display_long)|uniprotkb:GCC2(gene name)|psi-mi:GCC2(display_short)|uniprotkb:KIAA0336(gene name synonym)|uniprotkb:RANBP2L4(gene name synonym)|uniprotkb:185 kDa Golgi coiled-coil protein(gene name synonym)|uniprotkb:Ran-binding protein 2-like 4(gene name synonym)|uniprotkb:CTCL tumor antigen se1-1(gene name synonym)|uniprotkb:CLL-associated antigen KW-11(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-53(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_852118.1|refseq:XP_006712934.1|ensembl:ENSP00000307939|ensembl:ENST00000482325|ensembl:ENSP00000419969|ensembl:ENSG00000135968(gene)|ensembl:ENST00000309863(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0016020"(membrane)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034499"(late endosome to Golgi transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0070861"(regulation of protein exit from endoplasmic reticulum)|go:"GO:0071955"(recycling endosome to Golgi transport)|go:"GO:0090161"(Golgi ribbon formation)|interpro:IPR000237(GRIP)|interpro:IPR032023|rcsb pdb:3BBP|reactome:R-HSA-6811440	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:YeL/V7QABi3DbamH+qE6WfFLAco9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P19823	intact:EBI-2679332	intact:EBI-718353|uniprotkb:Q14659|uniprotkb:Q15484|uniprotkb:Q5T986|ensembl:ENSP00000351190	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:itih2_human(display_long)|uniprotkb:Inter-alpha-trypsin inhibitor complex component II(gene name synonym)|uniprotkb:Serum-derived hyaluronan-associated protein(gene name synonym)|uniprotkb:ITIH2(gene name)|psi-mi:ITIH2(display_short)|uniprotkb:IGHEP2(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002207.2|ensembl:ENSG00000151655(gene)|ensembl:ENST00000358415(transcript)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010600(Inter-alpha-trypsin inhibitor heavy chain, C-terminal)|interpro:IPR013694(Vault protein inter-alpha-trypsin)|interpro:IPR036465|reactome:R-HSA-381426|reactome:R-HSA-8957275	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:mxVXjhb1YohieImPswevFaJ/2Hw9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P08603	intact:EBI-2679332	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P0DJI9	intact:EBI-2679332	intact:EBI-6677144|ensembl:ENSP00000256733|ensembl:ENSP00000436126|ensembl:ENSP00000437162|uniprotkb:G3XAK9|uniprotkb:P02735|uniprotkb:P02736|uniprotkb:P02737|uniprotkb:Q16730|uniprotkb:Q16834|uniprotkb:Q16835|uniprotkb:Q16879|uniprotkb:Q3KRB3|uniprotkb:Q6FG67|uniprotkb:Q96QN0|uniprotkb:Q9UCK9|uniprotkb:Q9UCL0	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:saa2_human(display_long)|uniprotkb:SAA2(gene name)|psi-mi:SAA2(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000256733(transcript)|ensembl:ENST00000526900(transcript)|ensembl:ENST00000529528(transcript)|go:"GO:0006953"(acute-phase response)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000096(Serum amyloid A protein)|ensembl:ENSG00000134339(gene)|refseq:NP_001120852.1|refseq:NP_110381.2	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:UT6ucFWRwTXVZcdMxJK2zpEoFs09606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02765	intact:EBI-2679332	intact:EBI-1223374|uniprotkb:O14961|uniprotkb:O14962|uniprotkb:Q9P152|uniprotkb:A8K9N6|uniprotkb:B2R7G1|ensembl:ENSP00000393887	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:fetua_human(display_long)|uniprotkb:AHSG(gene name)|psi-mi:AHSG(display_short)|uniprotkb:FETUA(gene name synonym)|uniprotkb:PRO2743(orf name)|uniprotkb:Ba-alpha-2-glycoprotein(gene name synonym)|uniprotkb:Alpha-2-Z-globulin(gene name synonym)|uniprotkb:Fetuin-A(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001613.2|ensembl:ENSG00000145192(gene)|ensembl:ENST00000411641(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006907"(pinocytosis)|go:"GO:0006953"(acute-phase response)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR001363(Proteinase inhibitor I25C, fetuin, conserved site)|interpro:IPR025760|mint:P02765|reactome:R-HSA-114608|reactome:R-HSA-381426|reactome:R-HSA-6798695|reactome:R-HSA-8957275	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:2SoUaMokkmtdRNazI9k95s9E9H49606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P00739	intact:EBI-2679332	intact:EBI-6677180|ensembl:ENSP00000441828|uniprotkb:Q7LE20|uniprotkb:Q92658|uniprotkb:Q92659|uniprotkb:Q9ULB0	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:hptr_human(display_long)|uniprotkb:HPR(gene name)|psi-mi:HPR(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000261701(gene)|ensembl:ENST00000540303(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0031638"(zymogen activation)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR008292(Haptoglobin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR035976|interpro:IPR043504|reactome:R-HSA-2168880|refseq:NP_066275.3	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:g6TDE3V7lRBWxMzOdilqdKZw7jc9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P27169	intact:EBI-2679332	intact:EBI-6677249|ensembl:ENSP00000222381|uniprotkb:B2RA40|uniprotkb:Q16052|uniprotkb:Q6B0J6|uniprotkb:Q9UCB1	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:pon1_human(display_long)|uniprotkb:PON1(gene name)|psi-mi:PON1(display_short)|uniprotkb:PON(gene name synonym)|uniprotkb:Aromatic esterase 1(gene name synonym)|uniprotkb:K-45(gene name synonym)|uniprotkb:Serum aryldialkylphosphatase 1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000005421(gene)|ensembl:ENST00000222381(transcript)|go:"GO:0004063"(aryldialkylphosphatase activity)|go:"GO:0004064"(arylesterase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046395"(carboxylic acid catabolic process)|go:"GO:0046434"(organophosphate catabolic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070542"(response to fatty acid)|go:"GO:0072562"(blood microparticle)|go:"GO:0102007"(acyl-L-homoserine-lactone lactonohydrolase activity)|go:"GO:1902617"(response to fluoride)|interpro:IPR002640(Arylesterase)|interpro:IPR008363(Paraoxonase1)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|rcsb pdb:1V04|rcsb pdb:1XHR|reactome:R-HSA-2142688|go:"GO:0019439"(aromatic compound catabolic process)|refseq:NP_000437.3	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:CIPEUz7TXSGFkSKB4vuLQ9Sp9cQ9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:O43866	intact:EBI-2679332	intact:EBI-2623436|uniprotkb:A8K7M5|uniprotkb:Q6UX63|ensembl:ENSP00000357156	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:cd5l_human(display_long)|uniprotkb:API6(gene name synonym)|uniprotkb:CT-2(gene name synonym)|uniprotkb:IgM-associated peptide(gene name synonym)|uniprotkb:SP-alpha(gene name synonym)|uniprotkb:UNQ203/PRO229(orf name)|uniprotkb:Apoptosis inhibitor expressed by macrophages(gene name synonym)|uniprotkb:CD5L(gene name)|psi-mi:CD5L(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001334627.1|refseq:NP_005885.1|ensembl:ENSG00000073754(gene)|ensembl:ENST00000368174(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009986"(cell surface)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0031638"(zymogen activation)|go:"GO:0072562"(blood microparticle)|go:"GO:1903661"(positive regulation of complement-dependent cytotoxicity)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:g+Yen5g8QKKkkcmIVSd0eylQJYg9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02774	intact:EBI-2679332	intact:EBI-715425|uniprotkb:Q16309|uniprotkb:Q16310|uniprotkb:B4DPP2|uniprotkb:Q53F31|uniprotkb:Q6GTG1|ensembl:ENSP00000273951|uniprotkb:D6RAK8	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:vtdb_human(display_long)|uniprotkb:Group-specific component(gene name synonym)|uniprotkb:Gc-globulin(gene name synonym)|uniprotkb:GC(gene name)|psi-mi:GC(display_short)|uniprotkb:Gc protein-derived macrophage activating factor(gene name synonym)|uniprotkb:Vitamin D-binding protein-macrophage activating factor(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000574.2|refseq:NP_001191235.1|refseq:NP_001191236.1|ensembl:ENSG00000145321(gene)|go:"GO:0003779"(actin binding)|go:"GO:0005499"(vitamin D binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0051180"(vitamin transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090482"(vitamin transmembrane transporter activity)|go:"GO:1902118"(calcidiol binding)|interpro:IPR000213(Vitamin D-binding protein)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR015247(Vitamin D binding protein, domain III)|interpro:IPR020857|interpro:IPR020858|mint:P02774|rcsb pdb:1J78|rcsb pdb:1J7E|rcsb pdb:1KW2|rcsb pdb:1KXP|rcsb pdb:1LOT|rcsb pdb:1MA9|reactome:R-HSA-196791|ensembl:ENST00000273951(transcript)|dip:DIP-17038N	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:HqqTzgR6+bey6fQFLPpQQtp4rus9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02751	intact:EBI-2679332	intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:4arZu49X8b+dthqaX4DIh59V8h09606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:B6ZDN3	intact:EBI-2679332	intact:EBI-6677102|ensembl:ENSP00000385936	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:b6zdn3_human(display_long)|uniprotkb:DCDC1(gene name)|psi-mi:DCDC1(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_065920.2|ensembl:ENSG00000170959(gene)|ensembl:ENST00000406071(transcript)|go:"GO:0008017"(microtubule binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:1902412"(regulation of mitotic cytokinesis)|interpro:IPR000772(Ricin B lectin)|interpro:IPR003533(Doublecortin)|interpro:IPR035992|interpro:IPR036572|interpro:IPR043188	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:gePQyiAcuozPH4eGkKcYfFg7gQ09606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02655	intact:EBI-2679332	intact:EBI-1223594|uniprotkb:Q9BS39|uniprotkb:Q9UDE3|uniprotkb:Q9UNK3|uniprotkb:C0JYY4|ensembl:ENSP00000466775|ensembl:ENSP00000252490	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:apoc2_human(display_long)|uniprotkb:APOC2(gene name)|psi-mi:APOC2(display_short)|uniprotkb:APC2(gene name synonym)|uniprotkb:Apolipoprotein C2(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677072|imex:IM-20862-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000474.2|ensembl:ENST00000252490(transcript)|ensembl:ENST00000590360(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0008289"(lipid binding)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010902"(positive regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010916"(negative regulation of very-low-density lipoprotein particle clearance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0032375"(negative regulation of cholesterol transport)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034370"(triglyceride-rich lipoprotein particle remodeling)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0042627"(chylomicron)|ensembl:ENSG00000234906(gene)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045833"(negative regulation of lipid metabolic process)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060230"(lipoprotein lipase activator activity)|go:"GO:0060697"(positive regulation of phospholipid catabolic process)|go:"GO:0070328"(triglyceride homeostasis)|interpro:IPR008019(Apolipoprotein C-II)|interpro:IPR023121|mint:P02655|rcsb pdb:1BY6|rcsb pdb:1I5J|rcsb pdb:1O8T|rcsb pdb:1SOH|reactome:R-HSA-8963888|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-8964058|reactome:R-HSA-9029569|reactome:R-HSA-975634	-	-	-	figure legend:Supplemental data 2-Table S2|comment:Serum used to determine this interaction came from healthy subjects.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:kuZbXiBCiqNW+LkINdKZODnrgho9606	intact-crc:B48D5F9B6257D574	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P04196	intact:EBI-2679332	intact:EBI-3915012|uniprotkb:B9EK35|uniprotkb:D3DNU7|ensembl:ENSP00000232003	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:hrg_human(display_long)|uniprotkb:HRG(gene name)|psi-mi:HRG(display_short)|uniprotkb:Histidine-proline-rich glycoprotein(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000403.1|ensembl:ENSG00000113905(gene)|ensembl:ENST00000232003(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002839"(positive regulation of immune response to tumor cell)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015886"(heme transport)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0020037"(heme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0036019"(endolysosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:2000504"(positive regulation of blood vessel remodeling)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|mint:P04196|reactome:R-HSA-114608|reactome:R-HSA-75205|go:"GO:0043254"(regulation of protein-containing complex assembly)|dip:DIP-47264N	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:o/MnMkd+IKLRtprrFoOapUuoVEs9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:O43866	intact:EBI-2679332	intact:EBI-2623436|uniprotkb:A8K7M5|uniprotkb:Q6UX63|ensembl:ENSP00000357156	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:cd5l_human(display_long)|uniprotkb:API6(gene name synonym)|uniprotkb:CT-2(gene name synonym)|uniprotkb:IgM-associated peptide(gene name synonym)|uniprotkb:SP-alpha(gene name synonym)|uniprotkb:UNQ203/PRO229(orf name)|uniprotkb:Apoptosis inhibitor expressed by macrophages(gene name synonym)|uniprotkb:CD5L(gene name)|psi-mi:CD5L(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001334627.1|refseq:NP_005885.1|ensembl:ENSG00000073754(gene)|ensembl:ENST00000368174(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0009986"(cell surface)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0031638"(zymogen activation)|go:"GO:0072562"(blood microparticle)|go:"GO:1903661"(positive regulation of complement-dependent cytotoxicity)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:g+Yen5g8QKKkkcmIVSd0eylQJYg9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q96K68	intact:EBI-2679332	intact:EBI-6677510	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:q96k68_human(display_long)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0016020"(membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:XTdU4HvBRVgwVBfrDLnQRg1GPn09606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P01619	intact:EBI-2679332	intact:EBI-1221053|uniprotkb:P01622|uniprotkb:P01621|uniprotkb:P01623|uniprotkb:P04206|uniprotkb:P06311|uniprotkb:P18135|uniprotkb:P18136|intact:EBI-6677691|intact:EBI-3048564|uniprotkb:A0A0B4J1Z6|uniprotkb:P01620|ensembl:ENSP00000418649|ensembl:ENSP00000487628	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:kv320_human(display_long)|uniprotkb:IGKV3-20(gene name)|psi-mi:IGKV3-20(display_short)|uniprotkb:Ig kappa chain V-III region B6(gene name synonym)|uniprotkb:Ig kappa chain V-III region GOL(gene name synonym)|uniprotkb:Ig kappa chain V-III region HAH(gene name synonym)|uniprotkb:Ig kappa chain V-III region HIC(gene name synonym)|uniprotkb:Ig kappa chain V-III region IARC/BL41(gene name synonym)|uniprotkb:Ig kappa chain V-III region NG9(gene name synonym)|uniprotkb:Ig kappa chain V-III region SIE(gene name synonym)|uniprotkb:Ig kappa chain V-III region Ti(gene name synonym)|uniprotkb:Ig kappa chain V-III region WOL(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000239951(gene)|ensembl:ENSG00000282402(gene)|ensembl:ENST00000492167(transcript)|ensembl:ENST00000632822(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003094"(glomerular filtration)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071748"(monomeric IgA immunoglobulin complex)|go:"GO:0071751"(secretory IgA immunoglobulin complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1DH5|rcsb pdb:4LRN|rcsb pdb:4M62|rcsb pdb:4M8Q|rcsb pdb:4OB5|rcsb pdb:4ODX|reactome:R-HSA-166663|reactome:R-HSA-173623|go:"GO:0071756"(pentameric IgM immunoglobulin complex)|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-5690714|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|reactome:R-HSA-983695	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:A3tiGZV68B7iHX4VcexKiL7V6bE9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02655	intact:EBI-2679332	intact:EBI-1223594|uniprotkb:Q9BS39|uniprotkb:Q9UDE3|uniprotkb:Q9UNK3|uniprotkb:C0JYY4|ensembl:ENSP00000466775|ensembl:ENSP00000252490	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:apoc2_human(display_long)|uniprotkb:APOC2(gene name)|psi-mi:APOC2(display_short)|uniprotkb:APC2(gene name synonym)|uniprotkb:Apolipoprotein C2(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000474.2|ensembl:ENST00000252490(transcript)|ensembl:ENST00000590360(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0008289"(lipid binding)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010902"(positive regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010916"(negative regulation of very-low-density lipoprotein particle clearance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0032375"(negative regulation of cholesterol transport)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034370"(triglyceride-rich lipoprotein particle remodeling)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0042627"(chylomicron)|ensembl:ENSG00000234906(gene)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045833"(negative regulation of lipid metabolic process)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060230"(lipoprotein lipase activator activity)|go:"GO:0060697"(positive regulation of phospholipid catabolic process)|go:"GO:0070328"(triglyceride homeostasis)|interpro:IPR008019(Apolipoprotein C-II)|interpro:IPR023121|mint:P02655|rcsb pdb:1BY6|rcsb pdb:1I5J|rcsb pdb:1O8T|rcsb pdb:1SOH|reactome:R-HSA-8963888|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-8964058|reactome:R-HSA-9029569|reactome:R-HSA-975634	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:kuZbXiBCiqNW+LkINdKZODnrgho9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P51884	intact:EBI-2679332	intact:EBI-725780|uniprotkb:Q96QM7|uniprotkb:B2R6R5|ensembl:ENSP00000266718	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:lum_human(display_long)|uniprotkb:SLRR2D(gene name synonym)|uniprotkb:Keratan sulfate proteoglycan lumican(gene name synonym)|uniprotkb:LUM(gene name)|psi-mi:LUM(display_short)|uniprotkb:LDC(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002336.1|ensembl:ENSG00000139329(gene)|ensembl:ENST00000266718(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005583"(fibrillar collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007601"(visual perception)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070848"(response to growth factor)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027219|interpro:IPR032675|reactome:R-HSA-2022854|reactome:R-HSA-2022857|reactome:R-HSA-216083|reactome:R-HSA-3000178|reactome:R-HSA-3656225|reactome:R-HSA-3656243|reactome:R-HSA-3656244	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:+NFnJYYdpuAtRDyyW3CZE3mKEto9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02748	intact:EBI-2679332	intact:EBI-6677628|ensembl:ENSP00000263408	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:co9_human(display_long)|uniprotkb:C9(gene name)|psi-mi:C9(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001728.1|dip:DIP-1124N|ensembl:ENSG00000113600(gene)|ensembl:ENST00000263408(transcript)|go:"GO:0001906"(cell killing)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0019835"(cytolysis)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR036055|interpro:IPR036383|interpro:IPR037567|rcsb pdb:5FMW|rcsb pdb:6DLW|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:XzPZJ9OUi00H+87so48Q/n+GXds9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02647	intact:EBI-2679332	intact:EBI-701692|uniprotkb:Q6LDN9|uniprotkb:Q6Q785|uniprotkb:A8K866|uniprotkb:Q9UCS8|uniprotkb:Q9UCT8|ensembl:ENSP00000236850|ensembl:ENSP00000352471|ensembl:ENSP00000364469|ensembl:ENSP00000364472	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:apoa1_human(display_long)|uniprotkb:APOA1(gene name)|psi-mi:APOA1(display_short)|uniprotkb:Apolipoprotein A1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000030.1|refseq:NP_001304946.1|refseq:NP_001304947.1|refseq:NP_001304950.1|dip:DIP-29619N|ensembl:ENSG00000118137(gene)|ensembl:ENST00000236850(transcript)|ensembl:ENST00000359492(transcript)|ensembl:ENST00000375320(transcript)|ensembl:ENST00000375323(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0009986"(cell surface)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0018206"(peptidyl-methionine modification)|go:"GO:0019899"(enzyme binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030325"(adrenal gland development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051180"(vitamin transport)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070508"(cholesterol import)|go:"GO:0070653"(high-density lipoprotein particle receptor binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0072562"(blood microparticle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P02647|rcsb pdb:1AV1|rcsb pdb:1GW3|rcsb pdb:1GW4|rcsb pdb:1ODP|rcsb pdb:1ODQ|rcsb pdb:1ODR|rcsb pdb:2MSC|rcsb pdb:2MSD|rcsb pdb:2MSE|rcsb pdb:2N5E|rcsb pdb:3K2S|rcsb pdb:3R2P|rcsb pdb:4V6M|rcsb pdb:6CC9|rcsb pdb:6CCH|rcsb pdb:6CCX|rcsb pdb:6CLZ|rcsb pdb:6CM1|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6W4E|rcsb pdb:6W4F|rcsb pdb:7KJR|reactome:R-HSA-114608|reactome:R-HSA-1369062|reactome:R-HSA-1989781|reactome:R-HSA-2168880|reactome:R-HSA-3000471|reactome:R-HSA-3000480|reactome:R-HSA-381426|reactome:R-HSA-5682113|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963896|reactome:R-HSA-8963901|reactome:R-HSA-8964011|reactome:R-HSA-8964058|reactome:R-HSA-9707616|reactome:R-HSA-975634|reactome:R-HSA-977225	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:yEzPDeU8Uu/43dkLLOBAy6ey1vs9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q6PIQ7	intact:EBI-2679332	intact:EBI-6677651	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:q6piq7_human(display_long)|uniprotkb:IGL@(gene name)|psi-mi:IGL@(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0016020"(membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:/XY/PfSEF3LRlRKBLsY6gyeCogY9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P00736	intact:EBI-2679332	intact:EBI-3926504|uniprotkb:Q8J012|uniprotkb:Q68D77|uniprotkb:A6NJQ8	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:c1r_human(display_long)|uniprotkb:C1R(gene name)|psi-mi:C1R(display_short)|uniprotkb:Complement component 1 subcomponent r(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR035914|interpro:IPR035976|rcsb pdb:6F1C|rcsb pdb:6F1D|rcsb pdb:6F1H|refseq:NP_001724.3|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR018097|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR000436(Sushi/SCR/CCP)|rcsb pdb:1APQ|rcsb pdb:1GPZ|rcsb pdb:1MD7|rcsb pdb:1MD8|rcsb pdb:2QY0|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0031638"(zymogen activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR033116|rcsb pdb:6F39|interpro:IPR000742(EGF-like, type 3)|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|interpro:IPR035707|interpro:IPR043504	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:7E+ASC6Hv3CoXdwfWEMwCtYALbw9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	intact:EBI-6677706	intact:EBI-2679332	-	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:a2klm6_human(display_short)|psi-mi:EBI-6677706(display_long)|uniprotkb:IGVH(gene name)|psi-mi:IGVH(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	uniprotkb:A2KLM6(uniprot-removed-ac)	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:W+H4zTThwYEgWqSXgfeV7ovNoC09606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02679	intact:EBI-2679332	intact:EBI-1034422|uniprotkb:P04469|uniprotkb:P04470|uniprotkb:Q96A14|uniprotkb:Q96KJ3|uniprotkb:A8K057|uniprotkb:Q53Y18|uniprotkb:Q9UC62|uniprotkb:Q9UC63|uniprotkb:Q9UCF3|ensembl:ENSP00000336829	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:fibg_human(display_long)|uniprotkb:FGG(gene name)|psi-mi:FGG(display_short)|uniprotkb:PRO2061(orf name)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000500.2|refseq:NP_068656.2|ensembl:ENSG00000171557(gene)|ensembl:ENST00000336098(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0009306"(protein secretion)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0036345"(platelet maturation)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR037581|mint:P02679|rcsb pdb:1DUG|rcsb pdb:1FIB|rcsb pdb:1FIC|rcsb pdb:1FID|rcsb pdb:1FZA|go:"GO:0070527"(platelet aggregation)|rcsb pdb:1FZB|rcsb pdb:1FZC|rcsb pdb:1FZE|rcsb pdb:1FZF|rcsb pdb:1FZG|rcsb pdb:1LT9|rcsb pdb:1LTJ|rcsb pdb:1N86|rcsb pdb:1N8E|rcsb pdb:1RE3|rcsb pdb:1RE4|rcsb pdb:1RF0|rcsb pdb:1RF1|rcsb pdb:2A45|rcsb pdb:2FFD|rcsb pdb:2FIB|rcsb pdb:2H43|rcsb pdb:2HLO|rcsb pdb:2HOD|rcsb pdb:2HPC|rcsb pdb:2HWL|rcsb pdb:2OYH|rcsb pdb:2OYI|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:2VR3|rcsb pdb:2XNX|rcsb pdb:2XNY|rcsb pdb:2Y7L|rcsb pdb:2Z4E|rcsb pdb:3BVH|rcsb pdb:3E1I|rcsb pdb:2Q9I|rcsb pdb:3FIB|rcsb pdb:3GHG|rcsb pdb:3H32|rcsb pdb:3HUS|rcsb pdb:4B60|reactome:R-HSA-114608|reactome:R-HSA-1236974|reactome:R-HSA-140875|reactome:R-HSA-166058|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5674135|reactome:R-HSA-5686938|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223|dip:DIP-29644N	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:QKWesyU4/fduceFtu5zq31oGhYI9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P04004	intact:EBI-2679332	intact:EBI-1036653|uniprotkb:P01141|uniprotkb:Q9BSH7|uniprotkb:B2R7G0|ensembl:ENSP00000226218	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:vtnc_human(display_long)|uniprotkb:VTN(gene name)|psi-mi:VTN(display_short)|uniprotkb:Serum-spreading factor(gene name synonym)|uniprotkb:V75(gene name synonym)|uniprotkb:S-protein(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000629.3|ensembl:ENSG00000109072(gene)|ensembl:ENST00000226218(transcript)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061302"(smooth muscle cell-matrix adhesion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0072562"(blood microparticle)|go:"GO:0090303"(positive regulation of wound healing)|interpro:IPR000585(Hemopexin)|interpro:IPR001212(Somatomedin B)|interpro:IPR018486|interpro:IPR018487|interpro:IPR020436|interpro:IPR036024|interpro:IPR036375|mint:P04004|rcsb pdb:1OC0|rcsb pdb:1S4G|rcsb pdb:1SSU|rcsb pdb:2JQ8|rcsb pdb:3BT1|rcsb pdb:3BT2|rcsb pdb:4K24|rcsb pdb:6O5E|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-977606|dip:DIP-36566N	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:07qxfQS6kbUZGwPyNj8/LTetT6I9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P01599	intact:EBI-2679332	intact:EBI-6677677|uniprotkb:A0A0B4J1Z4|uniprotkb:P01610|ensembl:ENSP00000418357|ensembl:ENSP00000488092	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:kv117_human(display_long)|uniprotkb:IGKV1-17(gene name)|psi-mi:IGKV1-17(display_short)|uniprotkb:Ig kappa chain V-I region Gal(gene name synonym)|uniprotkb:Ig kappa chain V-I region WEA(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000240382(gene)|ensembl:ENSG00000281978(gene)|ensembl:ENST00000490686(transcript)|ensembl:ENST00000632229(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0019814"(immunoglobulin complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-5690714|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|reactome:R-HSA-983695	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:C6naq7kSjSMnEaxE0fDvFKOTFl49606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02766	intact:EBI-2679332	intact:EBI-711909|ensembl:ENSP00000237014|ensembl:ENSP00000497927|uniprotkb:Q6IB96|uniprotkb:Q9UBZ6|uniprotkb:Q9UCM9|uniprotkb:Q549C7	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:tthy_human(display_long)|uniprotkb:Prealbumin(gene name synonym)|uniprotkb:TBPA(gene name synonym)|uniprotkb:ATTR(gene name synonym)|uniprotkb:TTR(gene name)|psi-mi:TTR(display_short)|uniprotkb:PALB(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:3GLZ|rcsb pdb:3GPS|rcsb pdb:3GRB|rcsb pdb:3GRG|rcsb pdb:3GS0|rcsb pdb:3GS4|rcsb pdb:3GS7|rcsb pdb:3HJ0|rcsb pdb:3I9A|rcsb pdb:3I9I|rcsb pdb:3I9P|rcsb pdb:3IMR|rcsb pdb:3IMS|rcsb pdb:3IMT|rcsb pdb:3IMU|rcsb pdb:3IMV|rcsb pdb:3IMW|rcsb pdb:3IPB|rcsb pdb:3IPE|rcsb pdb:3KGS|rcsb pdb:3KGT|rcsb pdb:3KGU|rcsb pdb:3M1O|rcsb pdb:3NEE|rcsb pdb:3NEO|rcsb pdb:3NES|rcsb pdb:3NEX|rcsb pdb:3NG5|rcsb pdb:3OZK|rcsb pdb:3OZL|rcsb pdb:3FCB|rcsb pdb:3P3R|rcsb pdb:3P3S|rcsb pdb:3P3T|rcsb pdb:3P3U|rcsb pdb:3SSG|rcsb pdb:3TCT|rcsb pdb:3TFB|rcsb pdb:3U2I|rcsb pdb:3U2J|rcsb pdb:3W3B|rcsb pdb:4ABQ|rcsb pdb:4ABU|rcsb pdb:4ABV|rcsb pdb:4ABW|rcsb pdb:4AC2|rcsb pdb:4AC4|rcsb pdb:4ACT|rcsb pdb:4ANK|rcsb pdb:4D7B|rcsb pdb:4DER|rcsb pdb:4DES|rcsb pdb:4DET|rcsb pdb:4DEU|rcsb pdb:4DEW|rcsb pdb:4FI6|rcsb pdb:4FI7|rcsb pdb:4FI8|rcsb pdb:4HIQ|rcsb pdb:4HIS|rcsb pdb:4HJS|rcsb pdb:4HJT|rcsb pdb:4HJU|rcsb pdb:4I85|rcsb pdb:4I87|rcsb pdb:4IIZ|rcsb pdb:4IK6|rcsb pdb:4IK7|rcsb pdb:4IKI|rcsb pdb:4IKJ|rcsb pdb:4IKK|rcsb pdb:4IKL|rcsb pdb:4KY2|rcsb pdb:4L1S|rcsb pdb:4L1T|rcsb pdb:4MAS|rcsb pdb:4MRB|rcsb pdb:4MRC|rcsb pdb:4N85|rcsb pdb:4N86|rcsb pdb:4N87|rcsb pdb:4PM1|rcsb pdb:4PME|rcsb pdb:4PMF|rcsb pdb:4PVL|rcsb pdb:4PVM|rcsb pdb:4PVN|rcsb pdb:4I89|rcsb pdb:4PWE|rcsb pdb:4PWF|rcsb pdb:4PWG|rcsb pdb:4TLK|rcsb pdb:4TLS|rcsb pdb:4TLT|rcsb pdb:4TLU|rcsb pdb:4TM9|rcsb pdb:4TNE|rcsb pdb:4PWH|rcsb pdb:4TNF|rcsb pdb:4TNG|rcsb pdb:4TQ8|rcsb pdb:4TQH|rcsb pdb:4TQI|rcsb pdb:4TQP|rcsb pdb:4PWI|rcsb pdb:4PWJ|rcsb pdb:4PWK|rcsb pdb:4QRF|rcsb pdb:4WNJ|rcsb pdb:4WNS|rcsb pdb:4QXV|rcsb pdb:4QYA|rcsb pdb:4WO0|rcsb pdb:4TKW|rcsb pdb:4TL4|rcsb pdb:4TL5|rcsb pdb:4Y9B|rcsb pdb:4Y9C|rcsb pdb:4Y9E|rcsb pdb:4Y9F|rcsb pdb:4Y9G|rcsb pdb:4YDM|rcsb pdb:4YDN|rcsb pdb:5A6I|rcsb pdb:5AKS|rcsb pdb:5AKT|rcsb pdb:5AKV|rcsb pdb:5AL0|rcsb pdb:5AYT|rcsb pdb:5BOJ|rcsb pdb:5CLX|rcsb pdb:5CLY|rcsb pdb:5CLZ|rcsb pdb:5CM1|rcsb pdb:5AL8|rcsb pdb:5CN3|rcsb pdb:5CNH|rcsb pdb:5CR1|rcsb pdb:5DEJ|rcsb pdb:5DWP|rcsb pdb:5E23|rcsb pdb:5E4A|rcsb pdb:5E4O|rcsb pdb:5EN3|rcsb pdb:5EZP|rcsb pdb:5FO2|rcsb pdb:5FW6|rcsb pdb:5FW7|rcsb pdb:5FW8|rcsb pdb:5H0V|rcsb pdb:5H0W|rcsb pdb:5H0X|rcsb pdb:5H0Y|rcsb pdb:5H0Z|rcsb pdb:5HJG|rcsb pdb:5IHH|rcsb pdb:5JID|rcsb pdb:5JIM|rcsb pdb:5JIQ|rcsb pdb:5K1J|rcsb pdb:5K1N|rcsb pdb:5L4F|rcsb pdb:5L4I|rcsb pdb:5L4M|rcsb pdb:5LLL|rcsb pdb:5LLV|rcsb pdb:5N5Q|rcsb pdb:5N62|rcsb pdb:5N7C|rcsb pdb:5NFE|rcsb pdb:5NFW|rcsb pdb:5OQ0|rcsb pdb:5TTR|rcsb pdb:5TZL|rcsb pdb:5U48|rcsb pdb:5U49|rcsb pdb:5U4A|rcsb pdb:5U4B|rcsb pdb:5U4C|rcsb pdb:5U4D|rcsb pdb:5U4E|rcsb pdb:5U4F|rcsb pdb:5U4G|rcsb pdb:6D0W|rcsb pdb:6E6Z|rcsb pdb:6E70|rcsb pdb:6E71|rcsb pdb:5L4J|rcsb pdb:6E72|rcsb pdb:6E73|rcsb pdb:6E74|rcsb pdb:6E75|rcsb pdb:6E76|rcsb pdb:6E77|rcsb pdb:6E78|rcsb pdb:6EP1|rcsb pdb:6FFT|rcsb pdb:6FWD|rcsb pdb:6FXU|rcsb pdb:6FZL|rcsb pdb:6GR7|rcsb pdb:6GRP|rcsb pdb:6IMX|rcsb pdb:6IMY|rcsb pdb:6KGB|rcsb pdb:6R66|rcsb pdb:6R67|rcsb pdb:6R68|rcsb pdb:6R6I|rcsb pdb:6SDZ|rcsb pdb:6SUG|rcsb pdb:6SUH|rcsb pdb:6TI9|rcsb pdb:6TJN|rcsb pdb:6TXV|rcsb pdb:6TXW|rcsb pdb:6U0Q|rcsb pdb:6XTK|rcsb pdb:7ACU|reactome:R-HSA-2453864|reactome:R-HSA-2453902|reactome:R-HSA-3000171|reactome:R-HSA-6798695|reactome:R-HSA-975634|reactome:R-HSA-977225|ensembl:ENST00000237014(transcript)|ensembl:ENST00000649620(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006144"(purine nucleobase metabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:0070327"(thyroid hormone transport)|interpro:IPR000895(Transthyretin)|interpro:IPR023416|interpro:IPR023418|interpro:IPR023419|interpro:IPR030178|interpro:IPR036817|mint:P02766|rcsb pdb:1BM7|rcsb pdb:1BMZ|rcsb pdb:1BZ8|rcsb pdb:1BZD|rcsb pdb:1BZE|rcsb pdb:1DVQ|rcsb pdb:1DVS|rcsb pdb:1DVT|rcsb pdb:1DVU|rcsb pdb:1DVX|rcsb pdb:1DVY|rcsb pdb:1DVZ|rcsb pdb:1E3F|rcsb pdb:1E4H|ensembl:ENSG00000118271(gene)|rcsb pdb:1E5A|rcsb pdb:1ETA|rcsb pdb:1ETB|rcsb pdb:1F41|rcsb pdb:1F64|rcsb pdb:1F86|rcsb pdb:1FH2|rcsb pdb:1FHN|rcsb pdb:1G1O|rcsb pdb:1GKO|rcsb pdb:1ICT|rcsb pdb:1III|rcsb pdb:1IIK|rcsb pdb:1IJN|rcsb pdb:1QAB|rcsb pdb:1QWH|rcsb pdb:1RLB|rcsb pdb:1SOK|rcsb pdb:1SOQ|rcsb pdb:1THA|rcsb pdb:1THC|rcsb pdb:1TLM|rcsb pdb:1TSH|rcsb pdb:1TT6|rcsb pdb:1TTA|rcsb pdb:1TTB|rcsb pdb:2F7I|rcsb pdb:2F8I|rcsb pdb:2FBR|rcsb pdb:2FLM|rcsb pdb:1TTC|rcsb pdb:2G3X|rcsb pdb:2G3Z|rcsb pdb:2G4E|rcsb pdb:2G4G|rcsb pdb:2G5U|rcsb pdb:2G9K|rcsb pdb:2GAB|rcsb pdb:2H4E|rcsb pdb:2M5N|rcsb pdb:2NBO|rcsb pdb:2NBP|rcsb pdb:2NOY|rcsb pdb:2PAB|rcsb pdb:2QEL|rcsb pdb:2QGB|rcsb pdb:2QGC|rcsb pdb:2QGD|rcsb pdb:1TTR|rcsb pdb:1TYR|rcsb pdb:1TZ8|rcsb pdb:1U21|rcsb pdb:2QGE|rcsb pdb:2ROX|rcsb pdb:2ROY|rcsb pdb:2TRH|rcsb pdb:2TRY|rcsb pdb:2WQA|rcsb pdb:3A4D|rcsb pdb:3A4E|rcsb pdb:3A4F|rcsb pdb:3B56|rcsb pdb:3BSZ|rcsb pdb:3BT0|rcsb pdb:3CBR|rcsb pdb:3CFM|rcsb pdb:3CFN|rcsb pdb:1X7S|rcsb pdb:1X7T|rcsb pdb:3CFQ|rcsb pdb:3CFT|rcsb pdb:3CN0|rcsb pdb:3CN1|rcsb pdb:3CN2|rcsb pdb:3CN3|rcsb pdb:3CN4|rcsb pdb:3CXF|rcsb pdb:3D2T|rcsb pdb:3D7P|rcsb pdb:3DGD|rcsb pdb:3DID|rcsb pdb:1Y1D|rcsb pdb:1Z7J|rcsb pdb:1ZCR|rcsb pdb:1ZD6|rcsb pdb:2B14|rcsb pdb:2B15|rcsb pdb:2B16|rcsb pdb:2B77|rcsb pdb:2B9A|rcsb pdb:3DJR|rcsb pdb:3DJS|rcsb pdb:3DJT|rcsb pdb:3DJZ|rcsb pdb:3DK0|rcsb pdb:3DK2|rcsb pdb:3DO4|rcsb pdb:3ESN|rcsb pdb:3ESO|rcsb pdb:3ESP|rcsb pdb:3FC8|refseq:NP_000362.1|dip:DIP-1083N	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:VwPs2NgicC89f7Ehgf4d6uE9DuU9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q6GMX3	intact:EBI-2679332	intact:EBI-6677439	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:q6gmx3_human(display_long)|uniprotkb:IGL@(gene name)|psi-mi:IGL@(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0016020"(membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:yIUeMYkZHPaQ+I3P3e7+4zfPybw9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P06727	intact:EBI-2679332	intact:EBI-1222447|uniprotkb:Q14CW8|uniprotkb:Q6Q787|uniprotkb:A8MSL6|ensembl:ENSP00000350425	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:apoa4_human(display_long)|uniprotkb:APOA4(gene name)|psi-mi:APOA4(display_short)|uniprotkb:Apolipoprotein A4(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000473.2|dip:DIP-38333N|ensembl:ENSG00000110244(gene)|ensembl:ENST00000357780(transcript)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006869"(lipid transport)|go:"GO:0006982"(response to lipid hydroperoxide)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034378"(chylomicron assembly)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034445"(negative regulation of plasma lipoprotein oxidation)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065005"(protein-lipid complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0120020"(cholesterol transfer activity)|interpro:IPR000074(Apolipoprotein A1/A4/E)|rcsb pdb:3S84|reactome:R-HSA-8963888|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634|reactome:R-HSA-977225|go:"GO:0070328"(triglyceride homeostasis)	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:95b7Xlqg/plh9/R7xhLBsMXQscM9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P19827	intact:EBI-2679332	intact:EBI-1223859|uniprotkb:P78455|uniprotkb:Q01746|uniprotkb:Q562G1|uniprotkb:B2RAH9|uniprotkb:A8K9N5|uniprotkb:B7Z558|uniprotkb:B7Z8C0|uniprotkb:F5H165|uniprotkb:F5H7Y8|ensembl:ENSP00000273283	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:itih1_human(display_long)|uniprotkb:ITIH1(gene name)|psi-mi:ITIH1(display_short)|uniprotkb:IGHEP1(gene name synonym)|uniprotkb:Inter-alpha-trypsin inhibitor complex component III(gene name synonym)|uniprotkb:Serum-derived hyaluronan-associated protein(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001159906.1|refseq:NP_002206.2|refseq:NP_001159907.1|ensembl:ENSG00000055957(gene)|ensembl:ENST00000273283(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010600(Inter-alpha-trypsin inhibitor heavy chain, C-terminal)|interpro:IPR013694(Vault protein inter-alpha-trypsin)|interpro:IPR036465|rcsb pdb:6FPY|rcsb pdb:6FPZ	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:n2PvDOqE4g9kMtDI+JmC2hBvHa89606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q96J84	intact:EBI-2679332	intact:EBI-3988456|ensembl:ENSP00000352138|uniprotkb:Q5W0F8|uniprotkb:Q5XKC6|uniprotkb:Q7Z696|uniprotkb:Q7Z7N8|uniprotkb:Q8TB15|uniprotkb:Q9H9N1|uniprotkb:Q9NVA5	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:kirr1_human(display_long)|uniprotkb:KIRREL1(gene name)|psi-mi:KIRREL1(display_short)|uniprotkb:KIRREL(gene name synonym)|uniprotkb:Kin of irregular chiasm-like protein 1(gene name synonym)|uniprotkb:NEPH1(gene name synonym)|uniprotkb:Nephrin-like protein 1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001273278.1|ensembl:ENSG00000183853(gene)|ensembl:ENST00000359209(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0017022"(myosin binding)|go:"GO:0031253"(cell projection membrane)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|refseq:NP_060710.3|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-373753|go:"GO:0098609"(cell-cell adhesion)|refseq:XP_005245362.1	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:AZjf1PpCzbkuNJngJUPYa7bWYAo9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P0C0L4	intact:EBI-2679332	intact:EBI-1223619|uniprotkb:P01028|uniprotkb:P78445|uniprotkb:Q13160|uniprotkb:Q13906|uniprotkb:Q14033|uniprotkb:Q14835|uniprotkb:Q5JQM8|uniprotkb:Q9NPK5|uniprotkb:Q9UIP5|uniprotkb:B0QZR6|uniprotkb:A6H8M8|uniprotkb:A6NHJ5|uniprotkb:A7E2V2|uniprotkb:B0V2C8|uniprotkb:B2RUT6|uniprotkb:B7ZVZ6|uniprotkb:Q4LE82|uniprotkb:Q5JNX2|uniprotkb:Q6P4R1|uniprotkb:Q6U2E5|uniprotkb:Q6U2E8|uniprotkb:Q6U2F0|uniprotkb:Q6U2F3|uniprotkb:Q6U2F4|uniprotkb:Q6U2F6|uniprotkb:Q6U2F8|uniprotkb:Q6U2G0|uniprotkb:Q96EG2|uniprotkb:Q96SA8|ensembl:ENSP00000388662|ensembl:ENSP00000396688|ensembl:ENSP00000372815	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:co4a_human(display_long)|uniprotkb:C4A(gene name)|psi-mi:C4A(display_short)|uniprotkb:CO4(gene name synonym)|uniprotkb:CPAMD2(gene name synonym)|uniprotkb:Acidic complement C4(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009224.2|refseq:NP_001002029.3|refseq:NP_001239133.1|ensembl:ENSG00000206340(gene)|ensembl:ENSG00000227746(gene)|ensembl:ENSG00000244731(gene)|ensembl:ENST00000383325(transcript)|ensembl:ENST00000421274(transcript)|ensembl:ENST00000428956(transcript)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR036595|interpro:IPR037569|interpro:IPR040839|interpro:IPR041555|rcsb pdb:1HZF|rcsb pdb:4FXG|rcsb pdb:4FXK|rcsb pdb:4XAM|rcsb pdb:5JPM|rcsb pdb:5JPN|rcsb pdb:5JTW|reactome:R-HSA-166663|reactome:R-HSA-174577|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-977606	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:nLlIFlW5RCngnXASkYPGREjA/1E9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q99645	intact:EBI-2679332	intact:EBI-6677336|ensembl:ENSP00000261172|uniprotkb:A8K3M7|uniprotkb:Q8NEJ5	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:epyc_human(display_long)|uniprotkb:EPYC(gene name)|psi-mi:EPYC(display_short)|uniprotkb:DSPG3(gene name synonym)|uniprotkb:PGLB(gene name synonym)|uniprotkb:SLRR3B(gene name synonym)|uniprotkb:Dermatan sulfate proteoglycan 3(gene name synonym)|uniprotkb:Proteoglycan-Lb(gene name synonym)|uniprotkb:Small chondroitin/dermatan sulfate proteoglycan(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000083782(gene)|ensembl:ENST00000261172(transcript)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0031012"(extracellular matrix)|go:"GO:0060348"(bone development)|go:"GO:0061975"(articular cartilage development)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027217|interpro:IPR032675|interpro:IPR043547|refseq:NP_004941.2	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:1qzc4zJzP7s4IHAGdKeYCcWtEjs9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:O15270	intact:EBI-2679332	intact:EBI-766136|uniprotkb:Q16685|ensembl:ENSP00000216484	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:sptc2_human(display_long)|uniprotkb:Serine-palmitoyl-CoA transferase 2(gene name synonym)|uniprotkb:Long chain base biosynthesis protein 2(gene name synonym)|uniprotkb:SPTLC2(gene name)|psi-mi:SPTLC2(display_short)|uniprotkb:KIAA0526(gene name synonym)|uniprotkb:LCB2(gene name synonym)|uniprotkb:Long chain base biosynthesis protein 2a(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004854.1|dip:DIP-34604N|ensembl:ENSG00000100596(gene)|ensembl:ENST00000216484(transcript)|go:"GO:0004758"(serine C-palmitoyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006686"(sphingomyelin biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017059"(serine C-palmitoyltransferase complex)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0046511"(sphinganine biosynthetic process)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:1904504"(positive regulation of lipophagy)|interpro:IPR001917(Aminotransferase, class-II, pyridoxal-phosphate binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:O15270|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0I|rcsb pdb:7K0J|rcsb pdb:7K0K|rcsb pdb:7K0L|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:9Y8pOwwEej+jqblWkGS0ixnNHLo9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P35542	intact:EBI-2679332	intact:EBI-750242|uniprotkb:Q6FHJ4|ensembl:ENSP00000278222	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:saa4_human(display_long)|uniprotkb:Constitutively expressed serum amyloid A protein(gene name synonym)|uniprotkb:SAA4(gene name)|psi-mi:SAA4(display_short)|uniprotkb:CSAA(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006503.2|ensembl:ENSG00000148965(gene)|ensembl:ENST00000278222(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0006953"(acute-phase response)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000096(Serum amyloid A protein)	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:ZOkx4/kGh+VTTXdEMq1GjT4ASl49606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02656	intact:EBI-2679332	intact:EBI-1220113|uniprotkb:Q08E83|uniprotkb:Q6Q786|ensembl:ENSP00000227667	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:apoc3_human(display_long)|uniprotkb:APOC3(gene name)|psi-mi:APOC3(display_short)|uniprotkb:Apolipoprotein C3(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000031.1|ensembl:ENSG00000110245(gene)|ensembl:ENST00000227667(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010916"(negative regulation of very-low-density lipoprotein particle clearance)|go:"GO:0010987"(negative regulation of high-density lipoprotein particle clearance)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0015485"(cholesterol binding)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045833"(negative regulation of lipid metabolic process)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060621"(negative regulation of cholesterol import)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070653"(high-density lipoprotein particle receptor binding)|interpro:IPR008403(Apolipoprotein CIII)|interpro:IPR038195|mint:P02656|rcsb pdb:2JQ3|reactome:R-HSA-8963888|reactome:R-HSA-8963901|reactome:R-HSA-8964058|reactome:R-HSA-975634	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:DDj33pQWDh0i5+mwMy16Dmg6JPg9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P00747	intact:EBI-2679332	intact:EBI-999394|uniprotkb:Q15146|uniprotkb:Q5TEH4|uniprotkb:Q6PA00|ensembl:ENSP00000308938	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:plmn_human(display_long)|uniprotkb:PLG(gene name)|psi-mi:PLG(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000292.1|ensembl:ENSG00000122194(gene)|ensembl:ENST00000308192(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007596"(blood coagulation)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0042730"(fibrinolysis)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0048771"(tissue remodeling)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0051919"(positive regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1990405"(protein antigen binding)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000001(Kringle)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003609(Apple-like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR023317|interpro:IPR033116|interpro:IPR038178|interpro:IPR043504|mint:P00747|rcsb pdb:1B2I|rcsb pdb:1BML|rcsb pdb:1BUI|rcsb pdb:1CEA|rcsb pdb:1CEB|rcsb pdb:1DDJ|rcsb pdb:1HPJ|rcsb pdb:1HPK|rcsb pdb:1I5K|rcsb pdb:1KI0|rcsb pdb:1KRN|rcsb pdb:1L4D|rcsb pdb:1L4Z|rcsb pdb:1PK4|rcsb pdb:1PKR|rcsb pdb:1PMK|rcsb pdb:1QRZ|rcsb pdb:1RJX|rcsb pdb:2DOH|rcsb pdb:2DOI|rcsb pdb:2KNF|rcsb pdb:2L0S|rcsb pdb:2PK4|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|rcsb pdb:3UIR|rcsb pdb:4A5T|rcsb pdb:4CIK|rcsb pdb:4DCB|rcsb pdb:4DUR|rcsb pdb:4DUU|rcsb pdb:5HPG|rcsb pdb:5UGD|rcsb pdb:5UGG|rcsb pdb:6D3X|rcsb pdb:6D3Y|rcsb pdb:6D3Z|rcsb pdb:6D40|rcsb pdb:6OG4|rcsb pdb:6OQJ|rcsb pdb:6OQK|rcsb pdb:6Q1U|rcsb pdb:6UZ4|rcsb pdb:6UZ5|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-186797|reactome:R-HSA-381426|reactome:R-HSA-75205	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:f9Y+uCcA1jrDN1AD/clsKtkZWEQ9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q6P5S8	intact:EBI-2679332	intact:EBI-6677662	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:q6p5s8_human(display_long)|uniprotkb:IGK@(gene name)|psi-mi:IGK@(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:2NXZ|rcsb pdb:2NY0|rcsb pdb:2NY2|rcsb pdb:2NY4|rcsb pdb:2NY5|rcsb pdb:2NY3|go:"GO:0016020"(membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR013106(Immunoglobulin V-set)|rcsb pdb:2NXY|rcsb pdb:2NY1|rcsb pdb:2NY6|interpro:IPR036179	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:QB5zWAe8CmRCxpvKVhbH7O6h56w9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02649	intact:EBI-2679332	intact:EBI-1222467|uniprotkb:C0JYY5|uniprotkb:Q9P2S4|uniprotkb:B2RC15|ensembl:ENSP00000252486	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:apoe_human(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000032.1|refseq:NP_001289617.1|refseq:NP_001289618.1|refseq:NP_001289619.1|refseq:NP_001289620.1|dip:DIP-1120N|ensembl:ENSG00000130203(gene)|ensembl:ENST00000252486(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007616"(long-term memory)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010467"(gene expression)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010877"(lipid transport involved in lipid storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016209"(antioxidant activity)|go:"GO:0017038"(protein import)|go:"GO:0019068"(virion assembly)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034447"(very-low-density lipoprotein particle clearance)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0046907"(intracellular transport)|go:"GO:0046911"(metal chelating activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0051651"(maintenance of location in cell)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071830"(triglyceride-rich lipoprotein particle clearance)|go:"GO:0071831"(intermediate-density lipoprotein particle clearance)|go:"GO:0072562"(blood microparticle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901627"(negative regulation of postsynaptic membrane organization)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902947"(regulation of tau-protein kinase activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1902999"(negative regulation of phospholipid efflux)|go:"GO:1903001"(negative regulation of lipid transport across blood-brain barrier)|go:"GO:1903002"(positive regulation of lipid transport across blood-brain barrier)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1905855"(positive regulation of heparan sulfate binding)|go:"GO:1905860"(positive regulation of heparan sulfate proteoglycan binding)|go:"GO:1905890"(regulation of cellular response to very-low-density lipoprotein particle stimulus)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990777"(lipoprotein particle)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P02649|rcsb pdb:1B68|rcsb pdb:1BZ4|rcsb pdb:1EA8|rcsb pdb:1GS9|rcsb pdb:1H7I|rcsb pdb:1LE2|rcsb pdb:1LE4|rcsb pdb:1LPE|rcsb pdb:1NFN|rcsb pdb:1NFO|rcsb pdb:1OEF|rcsb pdb:1OEG|rcsb pdb:1OR2|rcsb pdb:1OR3|rcsb pdb:2KC3|rcsb pdb:2KNY|rcsb pdb:2L7B|rcsb pdb:6IWB|rcsb pdb:6NCN|rcsb pdb:6NCO|reactome:R-HSA-1251985|reactome:R-HSA-3000480|reactome:R-HSA-381426|reactome:R-HSA-8864260|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963901|reactome:R-HSA-8964026|reactome:R-HSA-8964058|reactome:R-HSA-9029569|reactome:R-HSA-975634|reactome:R-HSA-977225	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:vnCU03+HdGblqtALKeOTZRx5/3E9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:A0M8Q6	intact:EBI-2679332	intact:EBI-6677450|uniprotkb:A0A075B6L1	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:iglc7_human(display_long)|uniprotkb:IGLC7(gene name)|psi-mi:IGLC7(display_short)|uniprotkb:Ig lambda-7 chain C region(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	reactome:R-HSA-5690714|reactome:R-HSA-202733|reactome:R-HSA-166663|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-983695|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|reactome:R-HSA-977606|interpro:IPR036179|reactome:R-HSA-9664323|reactome:R-HSA-9664422	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:JCCwWWPar7MJo8W5z0wjO/IR6mw9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P04003	intact:EBI-2679332	intact:EBI-978348|ensembl:ENSP00000356037|uniprotkb:Q5VVQ8	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:c4bpa_human(display_long)|uniprotkb:Proline-rich protein(gene name synonym)|uniprotkb:C4BPA(gene name)|psi-mi:C4BPA(display_short)|uniprotkb:C4BP(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000123838(gene)|ensembl:ENST00000367070(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0072562"(blood microparticle)|go:"GO:1903027"(regulation of opsonization)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|interpro:IPR040514|rcsb pdb:2A55|rcsb pdb:4B0F|rcsb pdb:5HYP|rcsb pdb:5HYT|rcsb pdb:5HYU|rcsb pdb:5HZP|rcsb pdb:5I0Q|reactome:R-HSA-977606|refseq:NP_000706.1|refseq:XP_005273308.1|refseq:XP_005273309.1	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:S0F99wuDTalS4UCuYGWbiCgWlO09606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P09871	intact:EBI-2679332	intact:EBI-2810045|uniprotkb:Q9UCU9|uniprotkb:Q9UCV3|uniprotkb:Q9UCU7|uniprotkb:Q9UCV5|uniprotkb:Q9UCV4|uniprotkb:Q9UCU8|uniprotkb:Q9UCV2|uniprotkb:Q9UCV1|uniprotkb:Q9UCV0|uniprotkb:Q9UM14|uniprotkb:D3DUT4|ensembl:ENSP00000328173|ensembl:ENSP00000354057|ensembl:ENSP00000385035	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:c1s_human(display_long)|uniprotkb:C1S(gene name)|psi-mi:C1S(display_short)|uniprotkb:C1 esterase(gene name synonym)|uniprotkb:Complement component 1 subcomponent s(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001725.1|refseq:NP_958850.1|ensembl:ENSG00000182326(gene)|ensembl:ENST00000328916(transcript)|ensembl:ENST00000360817(transcript)|ensembl:ENST00000406697(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035708|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:1ELV|rcsb pdb:1NZI|rcsb pdb:4J1Y|rcsb pdb:4LMF|rcsb pdb:4LOR|rcsb pdb:4LOS|rcsb pdb:4LOT|rcsb pdb:6F1C|rcsb pdb:6F1H|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|refseq:NP_001333779.1|refseq:XP_005253817.1	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:3zz5RwIqLyPO71zdCp5Vx7aVl+Y9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02765	intact:EBI-2679332	intact:EBI-1223374|uniprotkb:O14961|uniprotkb:O14962|uniprotkb:Q9P152|uniprotkb:A8K9N6|uniprotkb:B2R7G1|ensembl:ENSP00000393887	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:fetua_human(display_long)|uniprotkb:AHSG(gene name)|psi-mi:AHSG(display_short)|uniprotkb:FETUA(gene name synonym)|uniprotkb:PRO2743(orf name)|uniprotkb:Ba-alpha-2-glycoprotein(gene name synonym)|uniprotkb:Alpha-2-Z-globulin(gene name synonym)|uniprotkb:Fetuin-A(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001613.2|ensembl:ENSG00000145192(gene)|ensembl:ENST00000411641(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006907"(pinocytosis)|go:"GO:0006953"(acute-phase response)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR001363(Proteinase inhibitor I25C, fetuin, conserved site)|interpro:IPR025760|mint:P02765|reactome:R-HSA-114608|reactome:R-HSA-381426|reactome:R-HSA-6798695|reactome:R-HSA-8957275	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:2SoUaMokkmtdRNazI9k95s9E9H49606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q6GMW4	intact:EBI-2679332	intact:EBI-6677597	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:q6gmw4_human(display_long)|uniprotkb:IGL@(gene name)|psi-mi:IGL@(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0016020"(membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:jNw2CIoxtfHKzsE1z+4K1NeALlw9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P01042	intact:EBI-2679332	intact:EBI-6378713|ensembl:ENSP00000493985|uniprotkb:C9JEX1|uniprotkb:A8K474|uniprotkb:B2RCR2|uniprotkb:P01043|uniprotkb:Q53EQ0|uniprotkb:Q6PAU9|uniprotkb:Q7M4P1	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:kng1_human(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000113889(gene)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENST00000644859(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042311"(vasodilation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR002395(HMW kininogen)|interpro:IPR018073|interpro:IPR027358|mint:P01042|rcsb pdb:1NY2|rcsb pdb:2WOK|rcsb pdb:4ASQ|rcsb pdb:4ASR|rcsb pdb:4ECB|rcsb pdb:4ECC|rcsb pdb:5I25|rcsb pdb:6F27|rcsb pdb:6F3V|rcsb pdb:6F3W|rcsb pdb:6F3X|rcsb pdb:6F3Y|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-375276|reactome:R-HSA-381426|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-8957275|go:"GO:0005615"(extracellular space)|refseq:NP_000884.1|refseq:NP_001095886.1|refseq:NP_001159923.1	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:Z/DOKINto4Ygn9lYUu6nuHA3soM9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P19823	intact:EBI-2679332	intact:EBI-718353|uniprotkb:Q14659|uniprotkb:Q15484|uniprotkb:Q5T986|ensembl:ENSP00000351190	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:itih2_human(display_long)|uniprotkb:Inter-alpha-trypsin inhibitor complex component II(gene name synonym)|uniprotkb:Serum-derived hyaluronan-associated protein(gene name synonym)|uniprotkb:ITIH2(gene name)|psi-mi:ITIH2(display_short)|uniprotkb:IGHEP2(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002207.2|ensembl:ENSG00000151655(gene)|ensembl:ENST00000358415(transcript)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010600(Inter-alpha-trypsin inhibitor heavy chain, C-terminal)|interpro:IPR013694(Vault protein inter-alpha-trypsin)|interpro:IPR036465|reactome:R-HSA-381426|reactome:R-HSA-8957275	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:mxVXjhb1YohieImPswevFaJ/2Hw9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P05546	intact:EBI-2679332	intact:EBI-1221005|uniprotkb:Q6IBZ5|uniprotkb:D3DX34|uniprotkb:B2RAI1|ensembl:ENSP00000215727|ensembl:ENSP00000384050	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:hep2_human(display_long)|uniprotkb:SERPIND1(gene name)|psi-mi:SERPIND1(display_short)|uniprotkb:HCF2(gene name synonym)|uniprotkb:Heparin cofactor II(gene name synonym)|uniprotkb:Protease inhibitor leuserpin-2(gene name synonym)|uniprotkb:Serpin D1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000176.2|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006935"(chemotaxis)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033831|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|rcsb pdb:1JMJ|rcsb pdb:1JMO|rcsb pdb:2NAT|rcsb pdb:2NCU|rcsb pdb:2NCV|rcsb pdb:2NCW|rcsb pdb:6J12|rcsb pdb:6KBO|rcsb pdb:6KBV|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-381426|reactome:R-HSA-8957275|ensembl:ENSG00000099937(gene)|ensembl:ENST00000215727(transcript)|ensembl:ENST00000406799(transcript)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:lG/XASWu25/oH77pIGXK4quoqeU9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P04278	intact:EBI-2679332	intact:EBI-2116215|uniprotkb:P14689|uniprotkb:Q16616|uniprotkb:Q3MIL0|uniprotkb:Q6ISD2|uniprotkb:B0FWH4|uniprotkb:E9PGW1|uniprotkb:F5H5Z8|uniprotkb:I3L1N7|ensembl:ENSP00000369816	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:shbg_human(display_long)|uniprotkb:SHBG(gene name)|psi-mi:SHBG(display_short)|uniprotkb:Sex steroid-binding protein(gene name synonym)|uniprotkb:Testis-specific androgen-binding protein(gene name synonym)|uniprotkb:Testosterone-estrogen-binding globulin(gene name synonym)|uniprotkb:Testosterone-estradiol-binding globulin(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001139751.1|refseq:NP_001276042.1|refseq:NP_001276043.1|refseq:NP_001276044.1|refseq:NP_001276045.1|refseq:NP_001031.2|refseq:NP_001139752.1|refseq:NP_001139753.1|ensembl:ENSG00000129214(gene)|ensembl:ENST00000380450(transcript)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001791(Laminin G)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|rcsb pdb:1D2S|rcsb pdb:1F5F|rcsb pdb:1KDK|rcsb pdb:1KDM|rcsb pdb:1LHN|rcsb pdb:1LHO|rcsb pdb:1LHU|rcsb pdb:1LHV|rcsb pdb:1LHW|rcsb pdb:6PYA|rcsb pdb:6PYB|rcsb pdb:6PYF|rcsb pdb:6ULB	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:fTYn1HrbGYDuP+YwDyCrduvBfQ49606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02652	intact:EBI-2679332	intact:EBI-1171525|uniprotkb:B2R524|ensembl:ENSP00000356969	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:apoa2_human(display_long)|uniprotkb:APOA2(gene name)|psi-mi:APOA2(display_short)|uniprotkb:Apolipoprotein A2(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001634.1|ensembl:ENSG00000158874(gene)|ensembl:ENST00000367990(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0009749"(response to glucose)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0015485"(cholesterol binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0018206"(peptidyl-methionine modification)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032375"(negative regulation of cholesterol transport)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034370"(triglyceride-rich lipoprotein particle remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0046340"(diacylglycerol catabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060621"(negative regulation of cholesterol import)|go:"GO:0060695"(negative regulation of cholesterol transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070653"(high-density lipoprotein particle receptor binding)|go:"GO:0072562"(blood microparticle)|go:"GO:0120020"(cholesterol transfer activity)|interpro:IPR006801("Apolipoprotein A-II (ApoA-II)")|interpro:IPR036172|mint:P02652|reactome:R-HSA-1989781|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963901|reactome:R-HSA-975634	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:uTkwkAwBXAMjDt6PkLhEazATi4g9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P27169	intact:EBI-2679332	intact:EBI-6677249|ensembl:ENSP00000222381|uniprotkb:B2RA40|uniprotkb:Q16052|uniprotkb:Q6B0J6|uniprotkb:Q9UCB1	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:pon1_human(display_long)|uniprotkb:PON1(gene name)|psi-mi:PON1(display_short)|uniprotkb:PON(gene name synonym)|uniprotkb:Aromatic esterase 1(gene name synonym)|uniprotkb:K-45(gene name synonym)|uniprotkb:Serum aryldialkylphosphatase 1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000005421(gene)|ensembl:ENST00000222381(transcript)|go:"GO:0004063"(aryldialkylphosphatase activity)|go:"GO:0004064"(arylesterase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046395"(carboxylic acid catabolic process)|go:"GO:0046434"(organophosphate catabolic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070542"(response to fatty acid)|go:"GO:0072562"(blood microparticle)|go:"GO:0102007"(acyl-L-homoserine-lactone lactonohydrolase activity)|go:"GO:1902617"(response to fluoride)|interpro:IPR002640(Arylesterase)|interpro:IPR008363(Paraoxonase1)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|rcsb pdb:1V04|rcsb pdb:1XHR|reactome:R-HSA-2142688|go:"GO:0019439"(aromatic compound catabolic process)|refseq:NP_000437.3	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:CIPEUz7TXSGFkSKB4vuLQ9Sp9cQ9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q59GS1	intact:EBI-2679332	intact:EBI-6677245	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:q59gs1_human(display_long)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	-	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:0SE3Ycq4Y5UsscZ5FXxuS+AAy2c9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:B6ZDN3	intact:EBI-2679332	intact:EBI-6677102|ensembl:ENSP00000385936	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:b6zdn3_human(display_long)|uniprotkb:DCDC1(gene name)|psi-mi:DCDC1(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_065920.2|ensembl:ENSG00000170959(gene)|ensembl:ENST00000406071(transcript)|go:"GO:0008017"(microtubule binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:1902412"(regulation of mitotic cytokinesis)|interpro:IPR000772(Ricin B lectin)|interpro:IPR003533(Doublecortin)|interpro:IPR035992|interpro:IPR036572|interpro:IPR043188	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:gePQyiAcuozPH4eGkKcYfFg7gQ09606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:A0A5E4	intact:EBI-2679332	intact:EBI-6677170	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:a0a5e4_human(display_long)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0016020"(membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:lhrQIB2KZ4isPPMA91Yx4AIBG309606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02671	intact:EBI-2679332	intact:EBI-348571|ensembl:ENSP00000498441|uniprotkb:Q9BX62|uniprotkb:Q9UCH2|uniprotkb:A8K3E4|uniprotkb:Q4QQH7|uniprotkb:D3DP14|uniprotkb:D3DP15	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:fiba_human(display_long)|uniprotkb:FGA(gene name)|psi-mi:FGA(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000499.1|refseq:NP_068657.1|ensembl:ENSG00000171560(gene)|ensembl:ENST00000651975(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000261"(negative regulation of blood coagulation, common pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072377"(blood coagulation, common pathway)|interpro:IPR021996|interpro:IPR036056|interpro:IPR037579|mint:P02671|rcsb pdb:1BBR|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1DM4|rcsb pdb:1FPH|rcsb pdb:1FZA|rcsb pdb:1FZB|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|rcsb pdb:1FZC|rcsb pdb:1FZD|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0042730"(fibrinolysis)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1FZF|rcsb pdb:1FZG|rcsb pdb:1LT9|rcsb pdb:1LTJ|rcsb pdb:1N86|rcsb pdb:1N8E|rcsb pdb:1RE3|rcsb pdb:1RE4|rcsb pdb:1RF0|rcsb pdb:1RF1|rcsb pdb:1YCP|rcsb pdb:2A45|rcsb pdb:2FFD|rcsb pdb:2H43|rcsb pdb:2HLO|rcsb pdb:2HOD|rcsb pdb:2HPC|rcsb pdb:2OYH|rcsb pdb:2OYI|rcsb pdb:2Q9I|rcsb pdb:2XNX|rcsb pdb:2XNY|rcsb pdb:2Z4E|rcsb pdb:3AT0|rcsb pdb:1FZE|rcsb pdb:3BVH|rcsb pdb:3E1I|rcsb pdb:3GHG|rcsb pdb:3H32|rcsb pdb:3HUS|rcsb pdb:4F27|rcsb pdb:5CFA|reactome:R-HSA-114608|reactome:R-HSA-1236974|reactome:R-HSA-5674135|reactome:R-HSA-140875|reactome:R-HSA-166058|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-5686938|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-977225|dip:DIP-29643N	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:khlQGVpd+6qZLTrsT9KxlxgjMR09606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P00751	intact:EBI-2679332	intact:EBI-1223668|uniprotkb:Q53F89|uniprotkb:O15006|uniprotkb:Q29944|uniprotkb:Q5ST50|uniprotkb:Q96HX6|uniprotkb:Q9BTF5|uniprotkb:Q9BX92|uniprotkb:B0QZQ6|uniprotkb:Q5JP67|ensembl:ENSP00000382862|ensembl:ENSP00000388352|ensembl:ENSP00000389604|ensembl:ENSP00000391902|ensembl:ENSP00000411474|ensembl:ENSP00000411515|ensembl:ENSP00000413351|ensembl:ENSP00000414341|ensembl:ENSP00000414889|ensembl:ENSP00000416561|ensembl:ENSP00000401719	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:cfab_human(display_long)|uniprotkb:CFB(gene name)|psi-mi:CFB(display_short)|uniprotkb:BF(gene name synonym)|uniprotkb:BFD(gene name synonym)|uniprotkb:C3/C5 convertase(gene name synonym)|uniprotkb:Properdin factor B(gene name synonym)|uniprotkb:Glycine-rich beta glycoprotein(gene name synonym)|uniprotkb:PBF2(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001701.2|dip:DIP-38319N|ensembl:ENSG00000239754(gene)|ensembl:ENSG00000241253(gene)|ensembl:ENSG00000241534(gene)|ensembl:ENSG00000242335(gene)|ensembl:ENSG00000243570(gene)|ensembl:ENSG00000243649(gene)|ensembl:ENST00000399981(transcript)|ensembl:ENST00000417261(transcript)|ensembl:ENST00000419411(transcript)|ensembl:ENST00000419920(transcript)|ensembl:ENST00000424727(transcript)|ensembl:ENST00000425368(transcript)|ensembl:ENST00000426239(transcript)|ensembl:ENST00000427888(transcript)|ensembl:ENST00000433503(transcript)|ensembl:ENST00000436692(transcript)|ensembl:ENST00000455591(transcript)|go:"GO:0001848"(complement binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011360(Complement B/C2)|interpro:IPR018114|interpro:IPR028341|interpro:IPR033116|interpro:IPR035976|interpro:IPR036465|mint:P00751|rcsb pdb:1DLE|rcsb pdb:1Q0P|rcsb pdb:1RRK|rcsb pdb:1RS0|rcsb pdb:1RTK|rcsb pdb:2OK5|rcsb pdb:2WIN|rcsb pdb:2XWB|rcsb pdb:2XWJ|rcsb pdb:3HRZ|rcsb pdb:3HS0|rcsb pdb:6QSW|rcsb pdb:6QSX|rcsb pdb:6RAV|rcsb pdb:6RUR|rcsb pdb:6RUV|rcsb pdb:6T8U|rcsb pdb:6T8V|rcsb pdb:6T8W|rcsb pdb:7JTN|rcsb pdb:7JTQ|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-977606	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:A6O1R+3K/DVzxKoEh2sLjEmDY/s9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q9P0P1	intact:EBI-2679332	intact:EBI-6677110	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:q9p0p1_human(display_long)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	-	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:jAxWDUEJq8ylu4SG7eouaCvDXzI9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P01024	intact:EBI-2679332	intact:EBI-905851|uniprotkb:A7E236|ensembl:ENSP00000245907	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:co3_human(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:CPAMD1(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000055.2|dip:DIP-35180N|ensembl:ENSG00000125730(gene)|ensembl:ENST00000245907(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01024|rcsb pdb:1C3D|rcsb pdb:1GHQ|rcsb pdb:1W2S|rcsb pdb:2A73|rcsb pdb:2A74|rcsb pdb:2GOX|rcsb pdb:2I07|rcsb pdb:2ICE|rcsb pdb:2ICF|rcsb pdb:2NOJ|rcsb pdb:2QKI|rcsb pdb:2WII|rcsb pdb:2WIN|rcsb pdb:2WY7|rcsb pdb:2WY8|rcsb pdb:2XQW|rcsb pdb:2XWB|rcsb pdb:2XWJ|rcsb pdb:3D5R|rcsb pdb:3D5S|rcsb pdb:3G6J|rcsb pdb:3L3O|rcsb pdb:3L5N|rcsb pdb:3NMS|rcsb pdb:3OED|rcsb pdb:3OHX|rcsb pdb:3OXU|rcsb pdb:3RJ3|rcsb pdb:3T4A|rcsb pdb:4HW5|rcsb pdb:4HWJ|rcsb pdb:4I6O|rcsb pdb:4M76|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5FO7|rcsb pdb:5FO8|rcsb pdb:5FO9|rcsb pdb:5FOA|rcsb pdb:5FOB|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:6EHG|rcsb pdb:6RMT|rcsb pdb:6RMU|rcsb pdb:6RUR|rcsb pdb:6RUV|rcsb pdb:6S0B|rcsb pdb:6YO6|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-198933|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9660826|reactome:R-HSA-977606	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:6Axa89cCPpUXFsLnd7sCurZzLYI9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02760	intact:EBI-2679332	intact:EBI-2115136|uniprotkb:P00977|uniprotkb:P02759|uniprotkb:P78491|uniprotkb:Q2TU33|uniprotkb:Q5TBD7|uniprotkb:Q9UC58|uniprotkb:Q9UDI8|ensembl:ENSP00000265132	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:ambp_human(display_long)|uniprotkb:AMBP(gene name)|psi-mi:AMBP(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:ITIL(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001624.1|ensembl:ENSG00000106927(gene)|ensembl:ENST00000265132(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007565"(female pregnancy)|go:"GO:0009986"(cell surface)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019862"(IgA binding)|go:"GO:0020037"(heme binding)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042167"(heme catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046904"(calcium oxalate binding)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002968(Alpha-1-microglobulin)|interpro:IPR012674(Calycin)|interpro:IPR020901|interpro:IPR022272|interpro:IPR029856|interpro:IPR036880|rcsb pdb:1BIK|rcsb pdb:3QKG|rcsb pdb:4ES7|rcsb pdb:4U30|rcsb pdb:6EJ7|rcsb pdb:6EJ8|rcsb pdb:6EJ9|rcsb pdb:6EJA|rcsb pdb:6EJB|rcsb pdb:6EJC|rcsb pdb:6EJD|reactome:R-HSA-2168880	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:os91tgT4TUMZ1qCf3SRbW5mwlGI9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q6NSB4	intact:EBI-2679332	intact:EBI-6677608	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:q6nsb4_human(display_long)|uniprotkb:HP(gene name)|psi-mi:HP(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030492"(hemoglobin binding)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR008292(Haptoglobin)|interpro:IPR043504	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:lzHukeb3e1TQAnOWR5X9sjI5gYo9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:O95445	intact:EBI-2679332	intact:EBI-715018|uniprotkb:Q9P046|uniprotkb:Q9UMP6|uniprotkb:B0UX98|ensembl:ENSP00000365081|ensembl:ENSP00000372930|ensembl:ENSP00000389591|ensembl:ENSP00000394610|ensembl:ENSP00000398944|ensembl:ENSP00000401684|ensembl:ENSP00000405730|uniprotkb:Q5SRP4	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:apom_human(display_long)|uniprotkb:Protein G3a(gene name synonym)|uniprotkb:APOM(gene name)|psi-mi:APOM(display_short)|uniprotkb:G3A(gene name synonym)|uniprotkb:NG20(gene name synonym)|uniprotkb:HSPC336(orf name)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_061974.2|refseq:NP_001243098.1|ensembl:ENSG00000204444(gene)|ensembl:ENSG00000206409(gene)|ensembl:ENSG00000226215(gene)|ensembl:ENSG00000224290(gene)|ensembl:ENSG00000227567(gene)|ensembl:ENSG00000231974(gene)|ensembl:ENSG00000235754(gene)|ensembl:ENST00000375916(transcript)|ensembl:ENST00000383438(transcript)|ensembl:ENST00000426800(transcript)|ensembl:ENST00000430282(transcript)|ensembl:ENST00000432598(transcript)|ensembl:ENST00000436931(transcript)|ensembl:ENST00000441436(transcript)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0009749"(response to glucose)|go:"GO:0016209"(antioxidant activity)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034445"(negative regulation of plasma lipoprotein oxidation)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043691"(reverse cholesterol transport)|interpro:IPR012674(Calycin)|interpro:IPR022734|rcsb pdb:2WEW|rcsb pdb:2WEX|rcsb pdb:2YG2|reactome:R-HSA-975634	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:7NkqD+U3JA6Sti7JufvvOfwKI6U9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02774	intact:EBI-2679332	intact:EBI-715425|uniprotkb:Q16309|uniprotkb:Q16310|uniprotkb:B4DPP2|uniprotkb:Q53F31|uniprotkb:Q6GTG1|ensembl:ENSP00000273951|uniprotkb:D6RAK8	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:vtdb_human(display_long)|uniprotkb:Group-specific component(gene name synonym)|uniprotkb:Gc-globulin(gene name synonym)|uniprotkb:GC(gene name)|psi-mi:GC(display_short)|uniprotkb:Gc protein-derived macrophage activating factor(gene name synonym)|uniprotkb:Vitamin D-binding protein-macrophage activating factor(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000574.2|refseq:NP_001191235.1|refseq:NP_001191236.1|ensembl:ENSG00000145321(gene)|go:"GO:0003779"(actin binding)|go:"GO:0005499"(vitamin D binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0051180"(vitamin transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090482"(vitamin transmembrane transporter activity)|go:"GO:1902118"(calcidiol binding)|interpro:IPR000213(Vitamin D-binding protein)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR015247(Vitamin D binding protein, domain III)|interpro:IPR020857|interpro:IPR020858|mint:P02774|rcsb pdb:1J78|rcsb pdb:1J7E|rcsb pdb:1KW2|rcsb pdb:1KXP|rcsb pdb:1LOT|rcsb pdb:1MA9|reactome:R-HSA-196791|ensembl:ENST00000273951(transcript)|dip:DIP-17038N	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:HqqTzgR6+bey6fQFLPpQQtp4rus9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q5EFE6	intact:EBI-2679332	intact:EBI-6677618	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:q5efe6_human(display_long)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0016020"(membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:e5NP613mD+m+qr2AgZ6HRiBb78w9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q8IZT6	intact:EBI-2679332	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P08603	intact:EBI-2679332	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P18428	intact:EBI-2679332	intact:EBI-3927059|uniprotkb:B2R938|uniprotkb:Q9UD66|uniprotkb:O43438|uniprotkb:Q9H403|uniprotkb:Q92672|ensembl:ENSP00000217407	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:lbp_human(display_long)|uniprotkb:LBP(gene name)|psi-mi:LBP(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004130.2|ensembl:ENSG00000129988(gene)|ensembl:ENST00000217407(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006968"(cellular defense response)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0015920"(lipopolysaccharide transport)|go:"GO:0016020"(membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032490"(detection of molecule of bacterial origin)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033036"(macromolecule localization)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045919"(positive regulation of cytolysis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR001124(Lipid-binding serum glycoprotein)|interpro:IPR017942|interpro:IPR017943|interpro:IPR017954|interpro:IPR030180|interpro:IPR030675|interpro:IPR032942|reactome:R-HSA-166016|reactome:R-HSA-166020|reactome:R-HSA-5686938|reactome:R-HSA-6785807|go:"GO:0060265"(positive regulation of respiratory burst involved in inflammatory response)|dip:DIP-90N	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:dSU+dnC7sUIeRc5ff52LhvrF58o9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P20851	intact:EBI-2679332	intact:EBI-6677075|uniprotkb:A5JYP8|uniprotkb:D3DT81|uniprotkb:Q5VVR0|uniprotkb:Q9BS25|ensembl:ENSP00000243611|ensembl:ENSP00000356045|ensembl:ENSP00000375790	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:c4bpb_human(display_long)|uniprotkb:C4BPB(gene name)|psi-mi:C4BPB(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_005273311.1|refseq:NP_000707.1|refseq:NP_001017364.1|refseq:NP_001017365.1|refseq:NP_001017366.1|refseq:NP_001017367.1|ensembl:ENSG00000123843(gene)|ensembl:ENST00000243611(transcript)|ensembl:ENST00000367078(transcript)|ensembl:ENST00000391923(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:1903027"(regulation of opsonization)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-977606	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:h6kTgvDfw8LUJYECvNIAC2wkM8Y9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P10909	intact:EBI-2679332	intact:EBI-1104674|uniprotkb:B3KSE6|uniprotkb:P11380|uniprotkb:P11381|uniprotkb:Q5HYC1|uniprotkb:Q7Z5B9|uniprotkb:B2R9Q1|uniprotkb:Q2TU75|ensembl:ENSP00000315130|ensembl:ENSP00000385419|ensembl:ENSP00000429620	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:clus_human(display_long)|uniprotkb:CLU(gene name)|psi-mi:CLU(display_short)|uniprotkb:APOJ(gene name synonym)|uniprotkb:CLI(gene name synonym)|uniprotkb:KUB1(gene name synonym)|uniprotkb:Complement-associated protein SP-40,40(gene name synonym)|uniprotkb:Complement cytolysis inhibitor(gene name synonym)|uniprotkb:NA1/NA2(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:Testosterone-repressed prostate message 2(gene name synonym)|uniprotkb:Ku70-binding protein 1(gene name synonym)|uniprotkb:Aging-associated gene 4 protein(gene name synonym)|uniprotkb:AAG4(orf name)|uniprotkb:Sulfated glycoprotein 2(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0006629"(lipid metabolic process)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017038"(protein import)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000120885(gene)|ensembl:ENST00000316403(transcript)|ensembl:ENST00000405140(transcript)|ensembl:ENST00000523500(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002434"(immune complex clearance)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042583"(chromaffin granule)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097440"(apical dendrite)|go:"GO:0099020"(perinuclear endoplasmic reticulum lumen)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902847"(regulation of neuronal signal transduction)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1905892"(negative regulation of cellular response to thapsigargin)|go:"GO:1905895"(negative regulation of cellular response to tunicamycin)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000753(Clusterin-like)|interpro:IPR016014(Clusterin, N-terminal)|interpro:IPR016015(Clusterin, C-terminal)|interpro:IPR016016(Clusterin)|interpro:IPR033986|mint:P10909|reactome:R-HSA-114608|reactome:R-HSA-166665|reactome:R-HSA-6803157|go:"GO:0060548"(negative regulation of cell death)|reactome:R-HSA-977606|refseq:NP_001822.3|dip:DIP-37546N	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:qlCJp4zYTklC3YZNQvbLmZBiz4U9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P04217	intact:EBI-2679332	intact:EBI-3925937|uniprotkb:Q8IYJ6|uniprotkb:Q96P39|uniprotkb:Q68CK0|uniprotkb:A8K052|ensembl:ENSP00000263100	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:a1bg_human(display_long)|uniprotkb:A1BG(gene name)|psi-mi:A1BG(display_short)|uniprotkb:Alpha-1-B glycoprotein(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_570602.2|ensembl:ENSG00000121410(gene)|ensembl:ENST00000263100(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016332(Alpha-1B-glycoprotein/leukocyte immunoglobulin-like receptor)|interpro:IPR036179|reactome:R-HSA-114608|reactome:R-HSA-6798695	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:N/9VdAtd5nX1Ur1GLmb18hpbQrs9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02654	intact:EBI-2679332	intact:EBI-1220105|uniprotkb:Q6IB97|uniprotkb:B2R526|ensembl:ENSP00000465356|ensembl:ENSP00000468029|ensembl:ENSP00000468276	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:apoc1_human(display_long)|uniprotkb:APOC1(gene name)|psi-mi:APOC1(display_short)|uniprotkb:Apolipoprotein C1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001307994.1|refseq:NP_001307995.1|refseq:NP_001636.1|ensembl:ENSG00000130208(gene)|ensembl:ENST00000588750(transcript)|ensembl:ENST00000588802(transcript)|ensembl:ENST00000592535(transcript)|go:"GO:0004859"(phospholipase inhibitor activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010900"(negative regulation of phosphatidylcholine catabolic process)|go:"GO:0010916"(negative regulation of very-low-density lipoprotein particle clearance)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0032375"(negative regulation of cholesterol transport)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034369"(plasma lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0034447"(very-low-density lipoprotein particle clearance)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042627"(chylomicron)|go:"GO:0045833"(negative regulation of lipid metabolic process)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|interpro:IPR006781(Apolipoprotein C-I)|interpro:IPR043081|rcsb pdb:1ALE|rcsb pdb:1ALF|rcsb pdb:1IOJ|rcsb pdb:1OPP|rcsb pdb:6DVU|rcsb pdb:6DXR|rcsb pdb:6DZ6|rcsb pdb:6NF3|reactome:R-HSA-8866423|reactome:R-HSA-8964046|reactome:R-HSA-9029569|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:drINJ8xVRjctp7oXvnAj2n3wlwM9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P00734	intact:EBI-2679332	intact:EBI-297094|ensembl:ENSP00000308541|uniprotkb:B2R7F7|uniprotkb:B4E1A7|uniprotkb:Q4QZ40|uniprotkb:Q53H04|uniprotkb:Q53H06|uniprotkb:Q7Z7P3|uniprotkb:Q9UCA1|uniprotkb:Q69EZ7	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:thrb_human(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:1BTH|rcsb pdb:1C1U|rcsb pdb:1C1V|rcsb pdb:1C1W|rcsb pdb:1C4U|rcsb pdb:1C4V|rcsb pdb:1C4Y|rcsb pdb:1C5L|rcsb pdb:1C5N|rcsb pdb:1C5O|rcsb pdb:1CA8|rcsb pdb:1D3D|rcsb pdb:1D3P|rcsb pdb:1D3Q|rcsb pdb:1D3T|rcsb pdb:1D4P|rcsb pdb:1D6W|rcsb pdb:1BMN|rcsb pdb:1D9I|rcsb pdb:1DE7|rcsb pdb:1DIT|rcsb pdb:1DM4|rcsb pdb:1DOJ|rcsb pdb:1DWB|rcsb pdb:1DWC|rcsb pdb:1DWD|rcsb pdb:1LHF|rcsb pdb:1LHG|rcsb pdb:1MH0|rcsb pdb:1MU6|rcsb pdb:1MU8|rcsb pdb:1MUE|rcsb pdb:1NM6|rcsb pdb:1NO9|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|rcsb pdb:1NRR|rcsb pdb:1NRS|rcsb pdb:1DWE|rcsb pdb:1NT1|rcsb pdb:1NU7|rcsb pdb:1NU9|rcsb pdb:1KTT|rcsb pdb:1LHC|rcsb pdb:1NY2|rcsb pdb:1NZQ|rcsb pdb:1LHD|rcsb pdb:1O0D|rcsb pdb:1O2G|rcsb pdb:1LHE|rcsb pdb:1O5G|rcsb pdb:1OOK|rcsb pdb:1OYT|rcsb pdb:1P8V|rcsb pdb:1PPB|rcsb pdb:1HAG|rcsb pdb:1HAH|rcsb pdb:1DX5|rcsb pdb:1E0F|rcsb pdb:1EB1|rcsb pdb:1HAI|rcsb pdb:1HAO|rcsb pdb:1EOJ|rcsb pdb:1EOL|rcsb pdb:1FPC|rcsb pdb:1FPH|rcsb pdb:1HAP|rcsb pdb:1HBT|rcsb pdb:1G30|rcsb pdb:1G32|rcsb pdb:1G37|rcsb pdb:1GHV|rcsb pdb:1HDT|rcsb pdb:1HGT|rcsb pdb:1GHW|rcsb pdb:1GHX|rcsb pdb:1GHY|rcsb pdb:1GJ4|rcsb pdb:1GJ5|rcsb pdb:1HLT|rcsb pdb:1HUT|rcsb pdb:1HXE|rcsb pdb:1HXF|rcsb pdb:1IHS|rcsb pdb:1IHT|rcsb pdb:1H8D|rcsb pdb:1H8I|rcsb pdb:1JMO|rcsb pdb:1JOU|rcsb pdb:1JWT|rcsb pdb:1K21|rcsb pdb:1K22|rcsb pdb:1KTS|ensembl:ENST00000311907(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|ensembl:ENSG00000180210(gene)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0072562"(blood microparticle)|go:"GO:0042730"(fibrinolysis)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|rcsb pdb:1A3B|rcsb pdb:1A3E|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|rcsb pdb:1A46|rcsb pdb:1A4W|interpro:IPR018056|rcsb pdb:1A5G|rcsb pdb:1A61|rcsb pdb:1ABI|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|rcsb pdb:1ABJ|rcsb pdb:1AD8|interpro:IPR035972|rcsb pdb:1AE8|rcsb pdb:1AFE|rcsb pdb:1AHT|rcsb pdb:1AI8|rcsb pdb:1AIX|rcsb pdb:1AWF|rcsb pdb:1AWH|rcsb pdb:1AY6|interpro:IPR037111|rcsb pdb:1B5G|rcsb pdb:1B7X|rcsb pdb:1BA8|rcsb pdb:1BB0|rcsb pdb:1BCU|interpro:IPR038178|rcsb pdb:1BHX|interpro:IPR043504|mint:P00734|rcsb pdb:1BMM|rcsb pdb:1A2C|rcsb pdb:2ZI2|rcsb pdb:2ZIQ|rcsb pdb:2ZNK|rcsb pdb:2ZO3|rcsb pdb:3B23|rcsb pdb:2ZHW|rcsb pdb:3B9F|rcsb pdb:3BEF|rcsb pdb:3BEI|rcsb pdb:3BF6|rcsb pdb:3BIU|rcsb pdb:3BIV|rcsb pdb:3BV9|rcsb pdb:3C1K|rcsb pdb:3C27|rcsb pdb:3D49|rcsb pdb:3DA9|rcsb pdb:3DD2|rcsb pdb:3DHK|rcsb pdb:3DT0|rcsb pdb:3DUX|rcsb pdb:3E6P|rcsb pdb:3EE0|rcsb pdb:3EGK|rcsb pdb:3EQ0|rcsb pdb:3F68|rcsb pdb:3GIC|rcsb pdb:3GIS|rcsb pdb:3HAT|rcsb pdb:3HKJ|rcsb pdb:3HTC|rcsb pdb:3JZ1|rcsb pdb:3JZ2|rcsb pdb:3K65|rcsb pdb:3LDX|rcsb pdb:3LU9|rcsb pdb:3NXP|rcsb pdb:3P17|rcsb pdb:3P6Z|rcsb pdb:3P70|rcsb pdb:3PMH|rcsb pdb:3PO1|rcsb pdb:3QDZ|rcsb pdb:3QGN|rcsb pdb:3QLP|rcsb pdb:3QTO|rcsb pdb:3QTV|rcsb pdb:3QWC|rcsb pdb:3QX5|rcsb pdb:1QBV|rcsb pdb:1QHR|rcsb pdb:1QJ1|rcsb pdb:1QJ6|rcsb pdb:1TB6|rcsb pdb:1QJ7|rcsb pdb:1QUR|rcsb pdb:1RD3|rcsb pdb:1TBZ|rcsb pdb:1RIW|rcsb pdb:1THP|rcsb pdb:1THR|rcsb pdb:1THS|rcsb pdb:1SB1|rcsb pdb:1SFQ|rcsb pdb:1SG8|rcsb pdb:1SGI|rcsb pdb:1SHH|rcsb pdb:1TMB|rcsb pdb:1SL3|rcsb pdb:1SR5|rcsb pdb:1T4U|rcsb pdb:1T4V|rcsb pdb:1TA2|rcsb pdb:1TMT|rcsb pdb:1TMU|rcsb pdb:1TOM|rcsb pdb:1TQ0|rcsb pdb:1TQ7|rcsb pdb:1TWX|rcsb pdb:1UMA|rcsb pdb:1UVS|rcsb pdb:1VR1|rcsb pdb:1VZQ|rcsb pdb:1W7G|rcsb pdb:1WAY|rcsb pdb:1WBG|rcsb pdb:1XM1|rcsb pdb:1XMN|rcsb pdb:1YPE|rcsb pdb:1YPG|rcsb pdb:1YPJ|rcsb pdb:1YPK|rcsb pdb:1YPL|rcsb pdb:1TA6|rcsb pdb:1YPM|rcsb pdb:1Z71|rcsb pdb:2AFQ|rcsb pdb:2ANK|rcsb pdb:2ANM|rcsb pdb:2B5T|rcsb pdb:2BDY|rcsb pdb:2BVR|rcsb pdb:2BVS|rcsb pdb:2BVX|rcsb pdb:2BXT|rcsb pdb:2BXU|rcsb pdb:2C8W|rcsb pdb:2C8X|rcsb pdb:2C8Y|rcsb pdb:2C8Z|rcsb pdb:2C90|rcsb pdb:2C93|rcsb pdb:2CF8|rcsb pdb:2CF9|rcsb pdb:1Z8I|rcsb pdb:2CN0|rcsb pdb:2FEQ|rcsb pdb:1Z8J|rcsb pdb:1ZGI|rcsb pdb:1ZGV|rcsb pdb:1ZRB|rcsb pdb:2A0Q|rcsb pdb:2A2X|rcsb pdb:2FES|rcsb pdb:2GDE|rcsb pdb:2GP9|rcsb pdb:2A45|rcsb pdb:2H9T|rcsb pdb:2HGT|rcsb pdb:2HNT|rcsb pdb:2HPP|rcsb pdb:2HPQ|rcsb pdb:2HWL|rcsb pdb:3RLW|rcsb pdb:3RLY|rcsb pdb:3RM0|rcsb pdb:3R3G|rcsb pdb:3RM2|rcsb pdb:3RML|rcsb pdb:3RMM|rcsb pdb:3RMN|rcsb pdb:3RMO|rcsb pdb:3S7H|rcsb pdb:3S7K|rcsb pdb:3SHA|rcsb pdb:3SHC|rcsb pdb:3SI3|rcsb pdb:3SI4|rcsb pdb:3SQE|rcsb pdb:3SQH|rcsb pdb:3SV2|rcsb pdb:3T5F|rcsb pdb:3TU7|rcsb pdb:3U69|rcsb pdb:3U8O|rcsb pdb:3U8R|rcsb pdb:3U8T|rcsb pdb:3U98|rcsb pdb:3U9A|rcsb pdb:3UTU|rcsb pdb:3UWJ|rcsb pdb:3VXE|rcsb pdb:3VXF|rcsb pdb:4AX9|rcsb pdb:4AYV|rcsb pdb:4AYY|rcsb pdb:4AZ2|rcsb pdb:4BAH|rcsb pdb:4BAK|rcsb pdb:4BAM|rcsb pdb:4BAN|rcsb pdb:4BAO|rcsb pdb:4BAQ|rcsb pdb:4BOH|rcsb pdb:4CH2|rcsb pdb:4CH8|rcsb pdb:4DIH|rcsb pdb:4DII|rcsb pdb:4DT7|rcsb pdb:4DY7|rcsb pdb:4E05|rcsb pdb:4E7R|rcsb pdb:4H6S|rcsb pdb:4H6T|rcsb pdb:4HFP|rcsb pdb:4HTC|rcsb pdb:4HZH|rcsb pdb:4I7Y|rcsb pdb:4LOY|rcsb pdb:4LXB|rcsb pdb:4LZ1|rcsb pdb:4LZ4|rcsb pdb:4MLF|rcsb pdb:4NZQ|rcsb pdb:4O03|rcsb pdb:4RKJ|rcsb pdb:4RKO|rcsb pdb:4RN6|rcsb pdb:4THN|rcsb pdb:4UD9|rcsb pdb:4UDW|rcsb pdb:4UE7|rcsb pdb:4UEH|rcsb pdb:4UFD|rcsb pdb:4UFE|rcsb pdb:4UFF|rcsb pdb:4UFG|rcsb pdb:4YES|rcsb pdb:5A2M|rcsb pdb:5AF9|rcsb pdb:4E06|rcsb pdb:5AFY|rcsb pdb:5AHG|rcsb pdb:5CMX|rcsb pdb:5DO4|rcsb pdb:5E8E|rcsb pdb:5EDK|rcsb pdb:5EDM|rcsb pdb:5EW1|rcsb pdb:5EW2|rcsb pdb:5GDS|rcsb pdb:5GIM|rcsb pdb:5JDU|rcsb pdb:5JFD|rcsb pdb:5JZY|rcsb pdb:5L6N|rcsb pdb:5MJT|rcsb pdb:5MLS|rcsb pdb:5MM6|rcsb pdb:5NHU|rcsb pdb:5TO3|rcsb pdb:5Z5W|rcsb pdb:5Z5X|rcsb pdb:6BJR|rcsb pdb:6C2W|rcsb pdb:6EO6|rcsb pdb:6EO7|rcsb pdb:6EO8|rcsb pdb:6EO9|rcsb pdb:6V5T|rcsb pdb:7KME|rcsb pdb:8KME|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-416476|rcsb pdb:5AFZ|rcsb pdb:2JH5|rcsb pdb:2JH6|rcsb pdb:2OD3|rcsb pdb:2PGB|rcsb pdb:2PGQ|rcsb pdb:2PKS|rcsb pdb:2PW8|rcsb pdb:2R2M|rcsb pdb:2THF|rcsb pdb:2UUF|rcsb pdb:2UUJ|rcsb pdb:2UUK|rcsb pdb:2V3H|rcsb pdb:2V3O|rcsb pdb:2ZC9|rcsb pdb:2ZDA|rcsb pdb:2ZDV|rcsb pdb:2ZF0|rcsb pdb:2ZFF|rcsb pdb:2ZFP|rcsb pdb:2ZFQ|rcsb pdb:2ZFR|rcsb pdb:2ZG0|rcsb pdb:2JH0|rcsb pdb:2ZGB|rcsb pdb:2ZGX|rcsb pdb:2ZHE|rcsb pdb:2ZHF|rcsb pdb:2ZHQ|reactome:R-HSA-76009|reactome:R-HSA-9657688|reactome:R-HSA-9672391|reactome:R-HSA-977606|reactome:R-HSA-456926|refseq:NP_000497.1|refseq:NP_001298186.1|dip:DIP-6115N	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:f6OQ6v3WbFpxr7N6GhfZOHjSsTQ9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:A6NMZ7	intact:EBI-2679332	intact:EBI-6677488|ensembl:ENSP00000351310|uniprotkb:A7DZQ0|uniprotkb:A7DZQ1|uniprotkb:A7DZQ2|uniprotkb:Q69YT0	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:co6a6_human(display_long)|uniprotkb:COL6A6(gene name)|psi-mi:COL6A6(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_016861200.1|refseq:XP_016861201.1|refseq:XP_016861202.1|refseq:XP_016861203.1|refseq:XP_016861204.1|ensembl:ENSG00000206384(gene)|ensembl:ENST00000358511(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0007155"(cell adhesion)|go:"GO:0031012"(extracellular matrix)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR036465|reactome:R-HSA-1442490|reactome:R-HSA-1650814|reactome:R-HSA-186797|reactome:R-HSA-2022090|reactome:R-HSA-216083|reactome:R-HSA-3000178|reactome:R-HSA-419037|reactome:R-HSA-8948216|refseq:XP_011510727.1|refseq:XP_011510728.1|refseq:XP_011510730.1|refseq:XP_005247178.1|refseq:NP_001096078.1	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:myofH+ZEUVu3/R/67XCrqM8z8g09606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q14624	intact:EBI-2679332	intact:EBI-2115630|uniprotkb:Q15135|uniprotkb:Q9P190|uniprotkb:Q9UQ54|uniprotkb:B7Z545|uniprotkb:E9PGN5|ensembl:ENSP00000266041	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:itih4_human(display_long)|uniprotkb:ITIH4(gene name)|psi-mi:ITIH4(display_short)|uniprotkb:IHRP(gene name synonym)|uniprotkb:ITIHL1(gene name synonym)|uniprotkb:PK120(gene name synonym)|uniprotkb:Inter-alpha-trypsin inhibitor family heavy chain-related protein(gene name synonym)|uniprotkb:Plasma kallikrein sensitive glycoprotein 120(gene name synonym)|uniprotkb:PRO1851(orf name)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002209.2|refseq:NP_001159921.1|ensembl:ENSG00000055955(gene)|ensembl:ENST00000266041(transcript)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006953"(acute-phase response)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0034097"(response to cytokine)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010600(Inter-alpha-trypsin inhibitor heavy chain, C-terminal)|interpro:IPR013694(Vault protein inter-alpha-trypsin)|interpro:IPR036465|reactome:R-HSA-114608	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:eodZ+5rGLYkRTWAyHhnDazwtLaA9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q2KHM9	intact:EBI-2679332	intact:EBI-2805604|ensembl:ENSP00000355250|uniprotkb:Q2KHN0|uniprotkb:Q9UG45|uniprotkb:O94853|uniprotkb:A8KA11|uniprotkb:B7Z479|uniprotkb:Q05D97	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:moonr_human(display_long)|uniprotkb:KIAA0753(gene name)|psi-mi:KIAA0753(display_short)|uniprotkb:MNR(gene name synonym)|uniprotkb:OFD1- and FOPNL-interacting protein(gene name synonym)|uniprotkb:OFIP(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000198920(gene)|ensembl:ENST00000361413(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007099"(centriole replication)|go:"GO:0034451"(centriolar satellite)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR031447|refseq:NP_055619.2|refseq:XP_006721675.1|refseq:XP_016880945.1|dip:DIP-61716N	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:3VyGPv3YYzpSoaCWulihyoxODOA9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02675	intact:EBI-2679332	intact:EBI-1034445|uniprotkb:A0JLR9|uniprotkb:Q32Q65|uniprotkb:Q3KPF2|uniprotkb:B2R7G3|ensembl:ENSP00000306099	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:fibb_human(display_long)|uniprotkb:FGB(gene name)|psi-mi:FGB(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001171670.1|refseq:NP_005132.2|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0042730"(fibrinolysis)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051087"(chaperone binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|interpro:IPR037580|mint:P02675|rcsb pdb:1FZA|rcsb pdb:1FZB|rcsb pdb:1FZC|rcsb pdb:1FZE|rcsb pdb:1FZF|rcsb pdb:1FZG|rcsb pdb:1LT9|rcsb pdb:1LTJ|rcsb pdb:1N86|rcsb pdb:1N8E|rcsb pdb:1RE3|rcsb pdb:1RE4|rcsb pdb:1RF0|rcsb pdb:1RF1|rcsb pdb:2A45|rcsb pdb:2FFD|rcsb pdb:2H43|rcsb pdb:2HLO|rcsb pdb:2HOD|rcsb pdb:2HPC|rcsb pdb:2OYH|rcsb pdb:2OYI|rcsb pdb:2Q9I|rcsb pdb:2XNX|rcsb pdb:2XNY|rcsb pdb:2Z4E|rcsb pdb:3BVH|rcsb pdb:3E1I|rcsb pdb:3GHG|rcsb pdb:3H32|rcsb pdb:3HUS|rcsb pdb:6ATZ|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-114608|reactome:R-HSA-1236974|reactome:R-HSA-140875|reactome:R-HSA-166058|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5674135|reactome:R-HSA-5686938|reactome:R-HSA-6802946|ensembl:ENSG00000171564(gene)|ensembl:ENST00000302068(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-6802952|reactome:R-HSA-6802948|dip:DIP-385N	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:cbcOBnZB/W/Y7eE/IxM2HfZHpK49606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P01009	intact:EBI-2679332	intact:EBI-986224|uniprotkb:Q7M4R2|uniprotkb:Q86U18|uniprotkb:Q86U19|uniprotkb:Q96BF9|uniprotkb:Q96ES1|uniprotkb:Q9P1P0|uniprotkb:A6PX14|uniprotkb:Q0PVP5|uniprotkb:Q13672|uniprotkb:Q53XB8|uniprotkb:Q5U0M1|uniprotkb:B2RDQ8|uniprotkb:Q9UCE6|uniprotkb:Q9UCM3|ensembl:ENSP00000348068|ensembl:ENSP00000376802|ensembl:ENSP00000376803|ensembl:ENSP00000385960|ensembl:ENSP00000390299|ensembl:ENSP00000408474|ensembl:ENSP00000416066|ensembl:ENSP00000416354|ensembl:ENSP00000490054	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:a1at_human(display_long)|uniprotkb:Alpha-1 protease inhibitor(gene name synonym)|uniprotkb:Alpha-1-antiproteinase(gene name synonym)|uniprotkb:AAT(gene name synonym)|uniprotkb:PI(gene name synonym)|uniprotkb:PRO0684(orf name)|uniprotkb:PRO2209(orf name)|uniprotkb:SERPINA1(gene name)|psi-mi:SERPINA1(display_short)|uniprotkb:Serpin A1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000286.3|refseq:NP_001002235.1|refseq:NP_001002236.1|refseq:NP_001121172.1|refseq:NP_001121173.1|refseq:NP_001121174.1|refseq:NP_001121175.1|refseq:NP_001121176.1|refseq:NP_001121177.1|refseq:NP_001121178.1|refseq:NP_001121179.1|refseq:XP_016876859.1|dip:DIP-35493N|ensembl:ENSG00000197249(gene)|ensembl:ENST00000355814(transcript)|ensembl:ENST00000393087(transcript)|ensembl:ENST00000393088(transcript)|ensembl:ENST00000404814(transcript)|ensembl:ENST00000437397(transcript)|ensembl:ENST00000440909(transcript)|ensembl:ENST00000448921(transcript)|ensembl:ENST00000449399(transcript)|ensembl:ENST00000636712(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006953"(acute-phase response)|go:"GO:0007596"(blood coagulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01009|rcsb pdb:1ATU|rcsb pdb:1EZX|rcsb pdb:1HP7|rcsb pdb:1D5S|rcsb pdb:1IZ2|rcsb pdb:1KCT|rcsb pdb:1OO8|rcsb pdb:1OPH|rcsb pdb:1PSI|rcsb pdb:1QLP|rcsb pdb:1QMB|rcsb pdb:2D26|rcsb pdb:2QUG|rcsb pdb:3CWL|rcsb pdb:3CWM|rcsb pdb:3DRM|rcsb pdb:3DRU|rcsb pdb:3NDD|rcsb pdb:3NDF|rcsb pdb:3NE4|rcsb pdb:3T1P|rcsb pdb:4PYW|rcsb pdb:5IO1|rcsb pdb:5NBU|rcsb pdb:5NBV|rcsb pdb:6HX4|rcsb pdb:6I4V|rcsb pdb:6I7U|rcsb pdb:6IAY|rcsb pdb:6ROD|rcsb pdb:7AEL|rcsb pdb:7API|rcsb pdb:7NPK|rcsb pdb:7NPL|rcsb pdb:8API|rcsb pdb:9API|reactome:R-HSA-114608|reactome:R-HSA-204005|reactome:R-HSA-381426|reactome:R-HSA-5694530|reactome:R-HSA-6798695|reactome:R-HSA-8957275	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:eIbjQWRWsWv+B28IcSUIKJ+Eros9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P01859	intact:EBI-2679332	intact:EBI-1044662|uniprotkb:A6NE66|ensembl:ENSP00000374987|ensembl:ENSP00000480351	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:ighg2_human(display_long)|uniprotkb:IGHG2(gene name)|psi-mi:IGHG2(display_short)|uniprotkb:Ig gamma-2 chain C region(gene name synonym)|uniprotkb:Ig gamma-2 chain C region DOT(gene name synonym)|uniprotkb:Ig gamma-2 chain C region TIL(gene name synonym)|uniprotkb:Ig gamma-2 chain C region ZIE(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|rcsb pdb:4L4J|ensembl:ENSG00000211893(gene)|ensembl:ENSG00000274497(gene)|ensembl:ENST00000390545(transcript)|ensembl:ENST00000621803(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2QSC|rcsb pdb:4HAF|rcsb pdb:4HAG	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:EZkOg27Ga0FblVGpeMMQzW0s/xo9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q7Z351	intact:EBI-2679332	intact:EBI-6677357	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:q7z351_human(display_long)|uniprotkb:DKFZp686N02209(gene name)|psi-mi:DKFZp686N02209(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0016020"(membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:vwyOd/7l5spXu22MzBnwLTwczo49606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q9UPN9	intact:EBI-2679332	intact:EBI-2214398|uniprotkb:O95855|uniprotkb:Q5TG72|uniprotkb:Q5TG73|uniprotkb:Q5TG74|uniprotkb:Q9C017|uniprotkb:Q9UJ79|ensembl:ENSP00000351250	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:tri33_human(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRIM33(gene name synonym)|uniprotkb:TRIM33(gene name)|psi-mi:TRIM33(display_short)|uniprotkb:KIAA1113(gene name synonym)|uniprotkb:RFG7(gene name synonym)|uniprotkb:TIF1G(gene name synonym)|uniprotkb:Tripartite motif-containing protein 33(gene name synonym)|uniprotkb:Transcription intermediary factor 1-gamma(gene name synonym)|uniprotkb:Ectodermin homolog(gene name synonym)|uniprotkb:RET-fused gene 7 protein(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_056990.3|refseq:NP_148980.2|ensembl:ENSG00000197323(gene)|ensembl:ENST00000358465(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR019786|interpro:IPR019787|interpro:IPR027370|interpro:IPR036427|mint:Q9UPN9|rcsb pdb:3U5M|rcsb pdb:3U5N|rcsb pdb:3U5O|rcsb pdb:3U5P|rcsb pdb:5MR8|reactome:R-HSA-2173795|dip:DIP-54262N	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:DB02UIWcpeneONPdG17AS08/9/A9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q6N030	intact:EBI-2679332	intact:EBI-6677424	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:q6n030_human(display_long)|uniprotkb:DKFZp686I15212(gene name)|psi-mi:DKFZp686I15212(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:2NY3|go:"GO:0016020"(membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR013106(Immunoglobulin V-set)|rcsb pdb:2NY1|rcsb pdb:2NY6|interpro:IPR036179	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:+snXRtR7l8gkznx04PJ/NsYobT09606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P01023	intact:EBI-2679332	intact:EBI-640741|uniprotkb:Q13677|uniprotkb:Q59F47|uniprotkb:Q5QTS0|uniprotkb:Q68DN2|uniprotkb:Q6PIY3|uniprotkb:Q6PN97|ensembl:ENSP00000323929	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:a2mg_human(display_long)|uniprotkb:CPAMD5(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5(gene name synonym)|uniprotkb:A2M(gene name)|psi-mi:A2M(display_short)|uniprotkb:FWP007(orf name)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000005.2|refseq:NP_001334352.1|refseq:NP_001334353.1|refseq:NP_001334354.1|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR010916(TonB box, conserved site)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR019742|interpro:IPR036595|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813|mint:P01023|rcsb pdb:1BV8|rcsb pdb:2P9R|rcsb pdb:4ACQ|rcsb pdb:6TAV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-1474228|reactome:R-HSA-8963896|ensembl:ENSG00000175899(gene)|ensembl:ENST00000318602(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|dip:DIP-1118N	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:FClLRDrtOWUx0eBBCUfAocx0Q+49606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P00450	intact:EBI-2679332	intact:EBI-1220171|uniprotkb:Q14063|uniprotkb:Q2PP18|uniprotkb:Q9UKS4|ensembl:ENSP00000264613	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:ceru_human(display_long)|uniprotkb:CP(gene name)|psi-mi:CP(display_short)|uniprotkb:Ferroxidase(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000087.1|ensembl:ENSG00000047457(gene)|ensembl:ENST00000264613(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006825"(copper ion transport)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR001117(Multicopper oxidase, type 1)|interpro:IPR002355(Multicopper oxidase, copper-binding site)|interpro:IPR008972(Cupredoxin)|interpro:IPR011706(Multicopper oxidase, type 2)|interpro:IPR011707(Multicopper oxidase, type 3)|interpro:IPR033138|mint:P00450|rcsb pdb:1KCW|rcsb pdb:2J5W|rcsb pdb:4EJX|rcsb pdb:4ENZ|reactome:R-HSA-381426|reactome:R-HSA-425410|reactome:R-HSA-5619049|reactome:R-HSA-5619060|reactome:R-HSA-8957275|reactome:R-HSA-917937	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:bPuhUo8h0DvtcwLufTOOHxrl9NI9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02751	intact:EBI-2679332	intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:4arZu49X8b+dthqaX4DIh59V8h09606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P0DJI9	intact:EBI-2679332	intact:EBI-6677144|ensembl:ENSP00000256733|ensembl:ENSP00000436126|ensembl:ENSP00000437162|uniprotkb:G3XAK9|uniprotkb:P02735|uniprotkb:P02736|uniprotkb:P02737|uniprotkb:Q16730|uniprotkb:Q16834|uniprotkb:Q16835|uniprotkb:Q16879|uniprotkb:Q3KRB3|uniprotkb:Q6FG67|uniprotkb:Q96QN0|uniprotkb:Q9UCK9|uniprotkb:Q9UCL0	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:saa2_human(display_long)|uniprotkb:SAA2(gene name)|psi-mi:SAA2(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000256733(transcript)|ensembl:ENST00000526900(transcript)|ensembl:ENST00000529528(transcript)|go:"GO:0006953"(acute-phase response)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000096(Serum amyloid A protein)|ensembl:ENSG00000134339(gene)|refseq:NP_001120852.1|refseq:NP_110381.2	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:UT6ucFWRwTXVZcdMxJK2zpEoFs09606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:Q96CV9	intact:EBI-2679332	intact:EBI-748974|uniprotkb:Q5T672|uniprotkb:Q5T673|uniprotkb:Q5T674|uniprotkb:Q5T675|uniprotkb:Q7LDL9|uniprotkb:Q8N562|uniprotkb:Q9UET9|uniprotkb:Q9UEV4|uniprotkb:Q9Y218|uniprotkb:B3KP00|uniprotkb:D3DRS4|uniprotkb:D3DRS8|ensembl:ENSP00000263036|ensembl:ENSP00000368021|ensembl:ENSP00000368022|ensembl:ENSP00000368032	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:optn_human(display_long)|uniprotkb:HYPL(gene name synonym)|uniprotkb:Optic neuropathy-inducing protein(gene name synonym)|uniprotkb:E3-14.7K-interacting protein(gene name synonym)|uniprotkb:FIP-2(gene name synonym)|uniprotkb:Huntingtin-interacting protein L(gene name synonym)|uniprotkb:Huntingtin yeast partner L(gene name synonym)|uniprotkb:NEMO-related protein(gene name synonym)|uniprotkb:Transcription factor IIIA-interacting protein(gene name synonym)|uniprotkb:OPTN(gene name)|psi-mi:OPTN(display_short)|uniprotkb:FIP2(gene name synonym)|uniprotkb:GLC1E(gene name synonym)|uniprotkb:NRP(gene name synonym)|uniprotkb:HIP7(gene name synonym)|uniprotkb:Huntingtin-interacting protein 7(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001008212.1|refseq:NP_001008213.1|refseq:NP_001008214.1|refseq:NP_068815.2|ensembl:ENSG00000123240(gene)|ensembl:ENST00000263036(transcript)|ensembl:ENST00000378747(transcript)|ensembl:ENST00000378748(transcript)|ensembl:ENST00000378757(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR021063|interpro:IPR032419|interpro:IPR032939|interpro:IPR034735|mint:Q96CV9|rcsb pdb:2LO4|rcsb pdb:2LUE|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:5AAZ|rcsb pdb:5B83|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:7CZM|reactome:R-HSA-2565942|reactome:R-HSA-8854214|dip:DIP-42001N	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:jcCTXDx1bJq3K5mgNUD73jeWeBU9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P02768	intact:EBI-2679332	intact:EBI-714423|ensembl:ENSP00000295897|uniprotkb:Q645G4|uniprotkb:O95574|uniprotkb:P04277|uniprotkb:Q13140|uniprotkb:Q68DN5|uniprotkb:Q6UXK4|uniprotkb:Q86YG0|uniprotkb:Q9P157|uniprotkb:Q9P1I7|uniprotkb:Q9UHS3|uniprotkb:Q9UJZ0|intact:EBI-7301844|intact:MINT-1161169|uniprotkb:E7ESS9|uniprotkb:Q8IUK7	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:albu_human(display_long)|uniprotkb:GIG42(orf name)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:PRO0903(orf name)|uniprotkb:PRO1708(orf name)|uniprotkb:PRO2044(orf name)|uniprotkb:PRO2619(orf name)|uniprotkb:PRO2675(orf name)|uniprotkb:UNQ696/PRO1341(orf name)|uniprotkb:GIG20(orf name)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000163631(gene)|ensembl:ENST00000295897(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|rcsb pdb:1E78|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016209"(antioxidant activity)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0051087"(chaperone binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140272"(exogenous protein binding)|go:"GO:1903981"(enterobactin binding)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|interpro:IPR021177|mint:P02768|rcsb pdb:1AO6|rcsb pdb:1BJ5|rcsb pdb:1BKE|rcsb pdb:1BM0|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|rcsb pdb:6XV0|rcsb pdb:6YG9|rcsb pdb:6ZL1|rcsb pdb:7A9C|rcsb pdb:7AAE|rcsb pdb:7AAI|rcsb pdb:7D6J|rcsb pdb:7JWN|reactome:R-HSA-114608|reactome:R-HSA-159418|reactome:R-HSA-189451|reactome:R-HSA-189483|reactome:R-HSA-2168880|reactome:R-HSA-381426|reactome:R-HSA-879518|reactome:R-HSA-8957275|reactome:R-HSA-8964058|reactome:R-HSA-9707564|rcsb pdb:6WUW|rcsb pdb:1E7B|rcsb pdb:1E7C|rcsb pdb:1E7E|rcsb pdb:1E7F|rcsb pdb:1E7G|rcsb pdb:1E7H|rcsb pdb:1E7I|rcsb pdb:1GNI|rcsb pdb:1GNJ|rcsb pdb:1H9Z|rcsb pdb:1HA2|rcsb pdb:1HK1|rcsb pdb:1HK2|rcsb pdb:1HK3|rcsb pdb:1HK4|rcsb pdb:1HK5|rcsb pdb:1N5U|rcsb pdb:1O9X|rcsb pdb:1TF0|rcsb pdb:1UOR|rcsb pdb:1YSX|rcsb pdb:2BX8|rcsb pdb:2BXA|rcsb pdb:2BXB|rcsb pdb:2BXC|rcsb pdb:2BXD|rcsb pdb:1E7A|rcsb pdb:2BXE|rcsb pdb:2BXF|rcsb pdb:2BXG|rcsb pdb:2BXH|rcsb pdb:2BXI|rcsb pdb:2BXK|rcsb pdb:2BXL|rcsb pdb:2BXM|rcsb pdb:2BXN|rcsb pdb:2BXO|rcsb pdb:2BXP|rcsb pdb:2BXQ|rcsb pdb:2ESG|rcsb pdb:2I2Z|rcsb pdb:2I30|rcsb pdb:2N0X|rcsb pdb:2VDB|rcsb pdb:2VUE|rcsb pdb:2VUF|rcsb pdb:2XSI|rcsb pdb:2XVQ|rcsb pdb:2XVU|rcsb pdb:2XVV|rcsb pdb:2XVW|rcsb pdb:2XW0|rcsb pdb:2XW1|rcsb pdb:2YDF|rcsb pdb:3A73|rcsb pdb:3B9L|rcsb pdb:3B9M|rcsb pdb:3CX9|rcsb pdb:3JQZ|rcsb pdb:3JRY|rcsb pdb:3LU6|rcsb pdb:4HGM|rcsb pdb:4IW1|rcsb pdb:4IW2|rcsb pdb:4K2C|rcsb pdb:4K71|rcsb pdb:4L8U|rcsb pdb:4L9K|rcsb pdb:4L9Q|rcsb pdb:4LA0|rcsb pdb:4LB2|rcsb pdb:4LB9|rcsb pdb:4N0F|rcsb pdb:4N0U|rcsb pdb:4S1Y|rcsb pdb:4Z69|rcsb pdb:5FUO|rcsb pdb:5GIX|rcsb pdb:5GIY|rcsb pdb:5ID7|rcsb pdb:5IFO|rcsb pdb:5IJF|rcsb pdb:5UJB|rcsb pdb:5VNW|rcsb pdb:5X52|rcsb pdb:5YB1|rcsb pdb:5YOQ|rcsb pdb:5Z0B|rcsb pdb:6A7P|rcsb pdb:6EZQ|rcsb pdb:6HSC|rcsb pdb:6JE7|rcsb pdb:6L4K|rcsb pdb:6M4R|rcsb pdb:3LU7|rcsb pdb:3LU8|rcsb pdb:3SQJ|rcsb pdb:3TDL|rcsb pdb:3UIV|rcsb pdb:4BKE|rcsb pdb:4E99|rcsb pdb:4EMX|rcsb pdb:4G03|rcsb pdb:4G04|rcsb pdb:4HGK|rcsb pdb:6M58|rcsb pdb:6M5D|rcsb pdb:6M5E|rcsb pdb:6QIO|rcsb pdb:6QIP|rcsb pdb:6R7S|refseq:NP_000468.1|dip:DIP-29902N	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:kjtn5mBsCZz/NRkcyW5k3ZWeJBU9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P01705	intact:EBI-2679332	intact:EBI-6677203|uniprotkb:A0A075B6J5|ensembl:ENSP00000374841	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:lv223_human(display_long)|uniprotkb:IGLV2-23(gene name)|psi-mi:IGLV2-23(display_short)|uniprotkb:Ig lambda chain V-II region NEI(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-5690714|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|reactome:R-HSA-983695|ensembl:ENSG00000211660(gene)|ensembl:ENST00000390306(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0019814"(immunoglobulin complex)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:FzGXXlzNF4kvotCBkpajLDPd37Q9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P07225	intact:EBI-2679332	intact:EBI-2803380|uniprotkb:Q7Z715|uniprotkb:Q9UCZ8|uniprotkb:Q15518|uniprotkb:A8KAC9|uniprotkb:D3DN28|ensembl:ENSP00000330021|ensembl:ENSP00000377783	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:pros_human(display_long)|uniprotkb:PROS(gene name synonym)|uniprotkb:PROS1(gene name)|psi-mi:PROS1(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001301006.1|refseq:NP_000304.2|ensembl:ENSG00000184500(gene)|ensembl:ENST00000348974(transcript)|ensembl:ENST00000394236(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR018097|interpro:IPR033189|interpro:IPR035972|rcsb pdb:1Z6C|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-977606	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:Dzwsl0PAf4lRj25V/jOlfPQzvRU9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:16024"	uniprotkb:P13671	intact:EBI-2679332	intact:EBI-1753221|ensembl:ENSP00000263413|ensembl:ENSP00000338861	psi-mi:d-mannose(display_short)|psi-mi:"CHEBI:16024"(display_long)	psi-mi:co6_human(display_long)|uniprotkb:C6(gene name)|psi-mi:C6(display_short)	psi-mi:"MI:0400"(affinity technology)	Yang et al. (2013)	pubmed:23300094|imex:IM-20862	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6677594|omim:114550|imex:IM-20862-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000056.2|refseq:NP_001108603.2|ensembl:ENSG00000039537(gene)|ensembl:ENST00000263413(transcript)|ensembl:ENST00000337836(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0019835"(cytolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR035976|interpro:IPR036055|interpro:IPR036383|rcsb pdb:3T5O|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	-	-	-	figure legend:Supplemental data 2 -Table S2|comment:Serum used to determine this interaction came from patients suffering hepatocellular carcinoma.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/20	2020/06/18	-	rogid:GfycGXFpIoDx8sLZwxVYVMaJp4g9606	intact-crc:22CD8DDCCD01EF00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)