#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:D7RIG0	uniprotkb:P28067	intact:EBI-25339681	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	psi-mi:d7rig0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Pos et al. (2012)	imex:IM-20531|pubmed:23260142	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656634|wwpdb:4gbx|wwpdb:4fqx|imex:IM-20531-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	-	no-uniprot-update:	-	figure legend:Fig. 1, Supp. Table 1|3d-r-factors:"Rworking = 0.19 Rfree = 0.24 (4fqx), Rworking = 0.2 Rfree = 0.25 (4gbx)"|3d-resolution:"2.6A (4fqx), 3.0A (4gbx)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/30	2021/02/11	rogid:vCNdHdbtlKcoI2NPKfDiiFm88sQ9606	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	intact-crc:3F3306792AF2403F|rigid:aGn+acPDXagHaJOsgUCfjB2nZvw	false	sufficient binding region:30-221	sufficient binding region:27-225	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:D7RIG0	uniprotkb:P28068	intact:EBI-25339681	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:d7rig0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Pos et al. (2012)	imex:IM-20531|pubmed:23260142	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656634|wwpdb:4gbx|wwpdb:4fqx|imex:IM-20531-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal)	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	-	no-uniprot-update:	-	figure legend:Fig. 1, Supp. Table 1|3d-r-factors:"Rworking = 0.19 Rfree = 0.24 (4fqx), Rworking = 0.2 Rfree = 0.25 (4gbx)"|3d-resolution:"2.6A (4fqx), 3.0A (4gbx)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/30	2021/02/11	rogid:vCNdHdbtlKcoI2NPKfDiiFm88sQ9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	intact-crc:3F3306792AF2403F|rigid:aGn+acPDXagHaJOsgUCfjB2nZvw	false	sufficient binding region:30-221	sufficient binding region:19-211|mutation:92-92|mutation:64-64	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:D7RIG0	uniprotkb:P01903	intact:EBI-25339681	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:d7rig0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Pos et al. (2012)	imex:IM-20531|pubmed:23260142	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656634|wwpdb:4gbx|wwpdb:4fqx|imex:IM-20531-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal)	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	-	no-uniprot-update:	-	figure legend:Fig. 1, Supp. Table 1|3d-r-factors:"Rworking = 0.19 Rfree = 0.24 (4fqx), Rworking = 0.2 Rfree = 0.25 (4gbx)"|3d-resolution:"2.6A (4fqx), 3.0A (4gbx)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/30	2021/02/11	rogid:vCNdHdbtlKcoI2NPKfDiiFm88sQ9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:3F3306792AF2403F|rigid:aGn+acPDXagHaJOsgUCfjB2nZvw	false	sufficient binding region:30-221	mutation:90-90|sufficient binding region:26-216	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:D7RIG0	intact:EBI-6656657	intact:EBI-25339681	-	psi-mi:d7rig0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)	psi-mi:gkqnclklatk peptide(display_short)|psi-mi:EBI-6656657(display_long)	psi-mi:"MI:0114"(x-ray crystallography)	Pos et al. (2012)	imex:IM-20531|pubmed:23260142	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656634|wwpdb:4gbx|wwpdb:4fqx|imex:IM-20531-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	go:"GO:0016021"(integral component of membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal)	-	-	no-uniprot-update:	-	figure legend:Fig. 1, Supp. Table 1|3d-r-factors:"Rworking = 0.19 Rfree = 0.24 (4fqx), Rworking = 0.2 Rfree = 0.25 (4gbx)"|3d-resolution:"2.6A (4fqx), 3.0A (4gbx)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/30	2021/02/11	rogid:vCNdHdbtlKcoI2NPKfDiiFm88sQ9606	rogid:A+5yscqOdNovPSwGltc3qhJylzE9606	intact-crc:3F3306792AF2403F|rigid:aGn+acPDXagHaJOsgUCfjB2nZvw	false	sufficient binding region:30-221	tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:D7RIG0	uniprotkb:P01903	intact:EBI-25339681	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:d7rig0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Pos et al. (2012)	imex:IM-20531|pubmed:23260142	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6657038|imex:IM-20531-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal)	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	-	no-uniprot-update:	-	figure legend:Fig. 5F, Supp. Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/30	2021/02/11	rogid:vCNdHdbtlKcoI2NPKfDiiFm88sQ9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:ACC514A551662B27|rigid:r58hVhwP/WFcMYlK7qwoyUqvmgA	false	mutation:59-59	mutation:90-90	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:D7RIG0	uniprotkb:P02686	intact:EBI-25339681	intact:EBI-947410|uniprotkb:A4FU54|uniprotkb:Q15337|uniprotkb:Q15338|uniprotkb:Q15339|uniprotkb:A8MY86|uniprotkb:A8MYL4|uniprotkb:A6NI84|uniprotkb:Q15340|uniprotkb:Q59GX3|uniprotkb:Q65ZS4|uniprotkb:Q6AI64|uniprotkb:Q6FH37|uniprotkb:Q6FI04|uniprotkb:Q6PK23|uniprotkb:B3KY66|uniprotkb:B7ZKS2|uniprotkb:B7ZKS4|ensembl:ENSP00000348273|ensembl:ENSP00000462223	psi-mi:d7rig0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)	psi-mi:mbp_human(display_long)|uniprotkb:MBP(gene name)|psi-mi:MBP(display_short)|uniprotkb:Myelin A1 protein(gene name synonym)|uniprotkb:Myelin membrane encephalitogenic protein(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Pos et al. (2012)	imex:IM-20531|pubmed:23260142	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6657038|imex:IM-20531-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal)	refseq:NP_001020252.1|refseq:NP_001020261.1|refseq:NP_001020263.1|refseq:NP_001020271.1|refseq:NP_001020272.1|refseq:NP_002376.1|refseq:XP_016881269.1|dip:DIP-36624N|ensembl:ENSG00000197971(gene)|ensembl:ENST00000355994(transcript)|ensembl:ENST00000580402(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002020"(protease binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007417"(central nervous system development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008366"(axon ensheathment)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0019911"(structural constituent of myelin sheath)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042552"(myelination)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043218"(compact myelin)|go:"GO:0045202"(synapse)|go:"GO:0061024"(membrane organization)|go:"GO:0071944"(cell periphery)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000548(Myelin basic protein)|mint:P02686|rcsb pdb:1BX2|rcsb pdb:1FV1|rcsb pdb:1HQR|rcsb pdb:1K2D|rcsb pdb:1QCL|rcsb pdb:1YMM|rcsb pdb:1ZGL|reactome:R-HSA-9619665	-	no-uniprot-update:	-	figure legend:Fig. 5F, Supp. Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/30	2021/02/11	rogid:vCNdHdbtlKcoI2NPKfDiiFm88sQ9606	rogid:ebDCekUqLVlpi0vmYj/WZjha+AQ9606	intact-crc:ACC514A551662B27|rigid:r58hVhwP/WFcMYlK7qwoyUqvmgA	false	mutation:59-59	alexa 488 label:?-?|sufficient binding region:85-99	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:D7RIG0	uniprotkb:P28067	intact:EBI-25339681	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	psi-mi:d7rig0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Pos et al. (2012)	imex:IM-20531|pubmed:23260142	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656738|imex:IM-20531-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	-	no-uniprot-update:	-	figure legend:Fig. 3F, Supp. Fig. 5A, 6D|comment:DRalpha Gln82Ala mutation reduces HLA-DMA activity in a pH-dependent manner|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/30	2021/02/11	rogid:vCNdHdbtlKcoI2NPKfDiiFm88sQ9606	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	intact-crc:7DAB893F1245C832|rigid:MDV2T2xzEeAIjP+oBJqEnnTpXwE	false	mutation:59-59	mutation decreasing interaction strength:92-92|mutation decreasing interaction strength:151-151|mutation decreasing interaction rate:151-151	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:D7RIG0	uniprotkb:P01903	intact:EBI-25339681	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:d7rig0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Pos et al. (2012)	imex:IM-20531|pubmed:23260142	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656738|imex:IM-20531-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal)	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	-	no-uniprot-update:	-	figure legend:Fig. 3F, Supp. Fig. 5A, 6D|comment:DRalpha Gln82Ala mutation reduces HLA-DMA activity in a pH-dependent manner|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/30	2021/02/11	rogid:vCNdHdbtlKcoI2NPKfDiiFm88sQ9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:7DAB893F1245C832|rigid:MDV2T2xzEeAIjP+oBJqEnnTpXwE	false	mutation:59-59	mutation decreasing interaction strength:76-76|mutation:90-90|mutation decreasing interaction strength:76-76|mutation decreasing interaction strength:125-125	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:D7RIG0	uniprotkb:P02686	intact:EBI-25339681	intact:EBI-947410|uniprotkb:A4FU54|uniprotkb:Q15337|uniprotkb:Q15338|uniprotkb:Q15339|uniprotkb:A8MY86|uniprotkb:A8MYL4|uniprotkb:A6NI84|uniprotkb:Q15340|uniprotkb:Q59GX3|uniprotkb:Q65ZS4|uniprotkb:Q6AI64|uniprotkb:Q6FH37|uniprotkb:Q6FI04|uniprotkb:Q6PK23|uniprotkb:B3KY66|uniprotkb:B7ZKS2|uniprotkb:B7ZKS4|ensembl:ENSP00000348273|ensembl:ENSP00000462223	psi-mi:d7rig0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)	psi-mi:mbp_human(display_long)|uniprotkb:MBP(gene name)|psi-mi:MBP(display_short)|uniprotkb:Myelin A1 protein(gene name synonym)|uniprotkb:Myelin membrane encephalitogenic protein(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Pos et al. (2012)	imex:IM-20531|pubmed:23260142	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656738|imex:IM-20531-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal)	refseq:NP_001020252.1|refseq:NP_001020261.1|refseq:NP_001020263.1|refseq:NP_001020271.1|refseq:NP_001020272.1|refseq:NP_002376.1|refseq:XP_016881269.1|dip:DIP-36624N|ensembl:ENSG00000197971(gene)|ensembl:ENST00000355994(transcript)|ensembl:ENST00000580402(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002020"(protease binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007417"(central nervous system development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008366"(axon ensheathment)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0019911"(structural constituent of myelin sheath)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042552"(myelination)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043218"(compact myelin)|go:"GO:0045202"(synapse)|go:"GO:0061024"(membrane organization)|go:"GO:0071944"(cell periphery)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000548(Myelin basic protein)|mint:P02686|rcsb pdb:1BX2|rcsb pdb:1FV1|rcsb pdb:1HQR|rcsb pdb:1K2D|rcsb pdb:1QCL|rcsb pdb:1YMM|rcsb pdb:1ZGL|reactome:R-HSA-9619665	-	no-uniprot-update:	-	figure legend:Fig. 3F, Supp. Fig. 5A, 6D|comment:DRalpha Gln82Ala mutation reduces HLA-DMA activity in a pH-dependent manner|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/04/30	2021/02/11	rogid:vCNdHdbtlKcoI2NPKfDiiFm88sQ9606	rogid:ebDCekUqLVlpi0vmYj/WZjha+AQ9606	intact-crc:7DAB893F1245C832|rigid:MDV2T2xzEeAIjP+oBJqEnnTpXwE	false	mutation:59-59	sufficient binding region:85-99|alexa 488 label:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P28067	uniprotkb:D7RIG0	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-25339681	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:d7rig0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Pos et al. (2012)	imex:IM-20531|pubmed:23260142	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656758|imex:IM-20531-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	go:"GO:0016021"(integral component of membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal)	-	-	no-uniprot-update:	figure legend:Fig. 5E, Supp Fig. 3E, 5B|kinetic_conditions:pH 7.0|comment:Kd varies from 2.7E-6 to 1.54E-5M from pH 5-7.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.54x10^-5(molar)	2013/04/30	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:vCNdHdbtlKcoI2NPKfDiiFm88sQ9606	intact-crc:1B2359274CF13719|rigid:K0xB3uWABvb3D3u7UpNw88SxTXw	false	biotin tag:c-c|mutation decreasing interaction rate:151-151|mutation decreasing interaction strength:151-151	mutation:59-59|fusion protein:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01903	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Pos et al. (2012)	imex:IM-20531|pubmed:23260142	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6656758|imex:IM-20531-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	-	-	-	figure legend:Fig. 5E, Supp Fig. 3E, 5B|kinetic_conditions:pH 7.0|comment:Kd varies from 2.7E-6 to 1.54E-5M from pH 5-7.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.54x10^-5(molar)	2013/04/30	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:1B2359274CF13719|rigid:K0xB3uWABvb3D3u7UpNw88SxTXw	false	biotin tag:c-c|mutation decreasing interaction rate:151-151|mutation decreasing interaction strength:151-151	mutation increasing interaction strength:76-76|mutation decreasing interaction strength:76-76|mutation increasing interaction strength:80-80|mutation:90-90|mutation decreasing interaction strength:125-125|mutation decreasing interaction strength:76-76	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)