#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9Y2R0 uniprotkb:P00395 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656474|imex:IM-18725-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5D|comment:participants seperated both by SDS-PAGE and BN-PAGE|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 intact-crc:AD456693FB61B686|rigid:Y6C6Qb56IgMr4gdedcmULcyJD+U false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:Q9BVV7 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656474|imex:IM-18725-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5D|comment:participants seperated both by SDS-PAGE and BN-PAGE|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 intact-crc:AD456693FB61B686|rigid:Y6C6Qb56IgMr4gdedcmULcyJD+U false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:Q02221 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-3907627|uniprotkb:Q6GTW6|uniprotkb:O00761|ensembl:ENSP00000287490 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cx6a2_human(display_long)|uniprotkb:COX6A2(gene name)|psi-mi:COX6A2(display_short)|uniprotkb:COX6A(gene name synonym)|uniprotkb:COX6AH(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide VIa-heart(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIA-muscle(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655893|imex:IM-18725-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_005196.1|ensembl:ENSG00000156885(gene)|ensembl:ENST00000287490(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030234"(enzyme regulator activity)|interpro:IPR001349(Cytochrome c oxidase, subunit VIa)|interpro:IPR018507|interpro:IPR036418 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:Np4BxYvAowYaVaX4ey8P/dktp449606 intact-crc:E74408A9A082442B|rigid:RRSXqbuEDaBmQtwDFRjmD+NWe4s false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:Q96I36 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6570698|ensembl:ENSP00000326052|ensembl:ENSP00000446524|ensembl:ENSP00000447776|ensembl:ENSP00000450331|uniprotkb:B2R5G6 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox14_human(display_long)|uniprotkb:COX14(gene name)|psi-mi:COX14(display_short)|uniprotkb:C12orf62(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655893|imex:IM-18725-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 ensembl:ENSG00000178449(gene)|ensembl:ENST00000317943(transcript)|ensembl:ENST00000548985(transcript)|ensembl:ENST00000550487(transcript)|ensembl:ENST00000550654(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR029208|reactome:R-HSA-5628897|reactome:R-HSA-611105|refseq:NP_001244062.1|refseq:NP_001244063.1|refseq:NP_116290.1|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:Vr9NrwDWz608Cjy6WwQjZup1bKQ9606 intact-crc:E74408A9A082442B|rigid:RRSXqbuEDaBmQtwDFRjmD+NWe4s false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:P13073 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655893|imex:IM-18725-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 intact-crc:E74408A9A082442B|rigid:RRSXqbuEDaBmQtwDFRjmD+NWe4s false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:P20674 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-715032|uniprotkb:P30045|intact:EBI-1043629|uniprotkb:Q8TB65|ensembl:ENSP00000317780|ensembl:ENSP00000456386 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox5a_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Va(gene name synonym)|uniprotkb:COX5A(gene name)|psi-mi:COX5A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655893|imex:IM-18725-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_004246.2|interpro:IPR003204(Cytochrome c oxidase, subunit Va)|interpro:IPR036545|mint:P20674|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000178741(gene)|ensembl:ENST00000322347(transcript)|ensembl:ENST00000564811(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity) go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:dWvZKYawyJQwN29Mhkm44DXXqhg9606 intact-crc:E74408A9A082442B|rigid:RRSXqbuEDaBmQtwDFRjmD+NWe4s false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:Q9GZY4 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6570735|uniprotkb:A6NJU8|uniprotkb:A8KAH8|uniprotkb:Q9HAB7|uniprotkb:Q9NVD2|ensembl:ENSP00000223336|ensembl:ENSP00000312100|ensembl:ENSP00000379218|ensembl:ENSP00000395586|ensembl:ENSP00000400759|ensembl:ENSP00000413777|ensembl:ENSP00000416406 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:coa1_human(display_long)|uniprotkb:COA1(gene name)|psi-mi:COA1(display_short)|uniprotkb:C7orf44(gene name synonym)|uniprotkb:MITRAC15(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655893|imex:IM-18725-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_060694.2|ensembl:ENSG00000106603(gene)|ensembl:ENST00000223336(transcript)|ensembl:ENST00000310564(transcript)|ensembl:ENST00000395879(transcript)|ensembl:ENST00000438444(transcript)|ensembl:ENST00000446330(transcript)|ensembl:ENST00000446564(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR014807(Protein of unknown function DUF1783, fungi)|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENST00000415076(transcript)|refseq:NP_001308126.1|refseq:NP_001308127.1|refseq:NP_001308128.1|refseq:NP_001308129.1|refseq:XP_005249864.1|refseq:XP_006715815.1|refseq:XP_016867903.1|refseq:XP_016867904.1|refseq:XP_016867905.1|refseq:XP_016867906.1|refseq:XP_016867907.1|refseq:XP_016867908.1|refseq:XP_016867910.1|refseq:XP_016867911.1|refseq:XP_016867912.1|refseq:XP_016867913.1|refseq:XP_016867914.1|refseq:XP_016867915.1|refseq:XP_016867916.1|refseq:XP_016867917.1|refseq:XP_016867918.1|refseq:XP_016867919.1|refseq:XP_016867920.1|refseq:XP_016867921.1 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:PWeLYXohVbUfWMoW71tQZo6pLn89606 intact-crc:E74408A9A082442B|rigid:RRSXqbuEDaBmQtwDFRjmD+NWe4s false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:Q9BVV7 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655893|imex:IM-18725-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 intact-crc:E74408A9A082442B|rigid:RRSXqbuEDaBmQtwDFRjmD+NWe4s false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:Q15526 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-3915286|uniprotkb:Q5T8T3|uniprotkb:Q5T8T4|ensembl:ENSP00000361042|ensembl:ENSP00000487158 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:surf1_human(display_long)|uniprotkb:SURF1(gene name)|psi-mi:SURF1(display_short)|uniprotkb:SURF-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655893|imex:IM-18725-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_003163.1|refseq:NP_001267716.1|ensembl:ENSG00000148290(gene)|ensembl:ENSG00000280627(gene)|ensembl:ENST00000371974(transcript)|ensembl:ENST00000626663(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR002994(Surfeit locus 1)|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:HGpXJhbeMdDuz7amqIgWqxlHicA9606 intact-crc:E74408A9A082442B|rigid:RRSXqbuEDaBmQtwDFRjmD+NWe4s false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:P00395 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655893|imex:IM-18725-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 intact-crc:E74408A9A082442B|rigid:RRSXqbuEDaBmQtwDFRjmD+NWe4s false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96I36 uniprotkb:P00395 intact:EBI-6570698|ensembl:ENSP00000326052|ensembl:ENSP00000446524|ensembl:ENSP00000447776|ensembl:ENSP00000450331|uniprotkb:B2R5G6 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:cox14_human(display_long)|uniprotkb:COX14(gene name)|psi-mi:COX14(display_short)|uniprotkb:C12orf62(gene name synonym) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655907|imex:IM-18725-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178449(gene)|ensembl:ENST00000317943(transcript)|ensembl:ENST00000548985(transcript)|ensembl:ENST00000550487(transcript)|ensembl:ENST00000550654(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR029208|reactome:R-HSA-5628897|reactome:R-HSA-611105|refseq:NP_001244062.1|refseq:NP_001244063.1|refseq:NP_116290.1|reactome:R-HSA-9707564 refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 3D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:Vr9NrwDWz608Cjy6WwQjZup1bKQ9606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 intact-crc:4406BE2B2017E766|rigid:Ja53/61nbrXANEcDMbAyk2t3PK4 false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96I36 uniprotkb:Q15526 intact:EBI-6570698|ensembl:ENSP00000326052|ensembl:ENSP00000446524|ensembl:ENSP00000447776|ensembl:ENSP00000450331|uniprotkb:B2R5G6 intact:EBI-3915286|uniprotkb:Q5T8T3|uniprotkb:Q5T8T4|ensembl:ENSP00000361042|ensembl:ENSP00000487158 psi-mi:cox14_human(display_long)|uniprotkb:COX14(gene name)|psi-mi:COX14(display_short)|uniprotkb:C12orf62(gene name synonym) psi-mi:surf1_human(display_long)|uniprotkb:SURF1(gene name)|psi-mi:SURF1(display_short)|uniprotkb:SURF-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655907|imex:IM-18725-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178449(gene)|ensembl:ENST00000317943(transcript)|ensembl:ENST00000548985(transcript)|ensembl:ENST00000550487(transcript)|ensembl:ENST00000550654(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR029208|reactome:R-HSA-5628897|reactome:R-HSA-611105|refseq:NP_001244062.1|refseq:NP_001244063.1|refseq:NP_116290.1|reactome:R-HSA-9707564 refseq:NP_003163.1|refseq:NP_001267716.1|ensembl:ENSG00000148290(gene)|ensembl:ENSG00000280627(gene)|ensembl:ENST00000371974(transcript)|ensembl:ENST00000626663(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR002994(Surfeit locus 1)|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 3D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:Vr9NrwDWz608Cjy6WwQjZup1bKQ9606 rogid:HGpXJhbeMdDuz7amqIgWqxlHicA9606 intact-crc:4406BE2B2017E766|rigid:Ja53/61nbrXANEcDMbAyk2t3PK4 false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q7Z7K0 uniprotkb:Q9Y2R0 intact:EBI-6570685|uniprotkb:Q68DJ7|ensembl:ENSP00000418348 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 psi-mi:coxm1_human(display_long)|uniprotkb:CMC1(gene name)|psi-mi:CMC1(display_short)|uniprotkb:C3orf68(gene name synonym) psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656012|imex:IM-18725-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_872329.1|ensembl:ENSG00000187118(gene)|ensembl:ENST00000466830(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0046872"(metal ion binding)|interpro:IPR013892(Protein of unknown function UPF0287) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 4F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:XLpcUQKNCUyL+bnDHXL5ibCYqLg9606 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 intact-crc:27211F79D29218C5|rigid:6JDCgJkVKavoF7qGFuEhsZvuf58 false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q7Z7K0 uniprotkb:P00395 intact:EBI-6570685|uniprotkb:Q68DJ7|ensembl:ENSP00000418348 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:coxm1_human(display_long)|uniprotkb:CMC1(gene name)|psi-mi:CMC1(display_short)|uniprotkb:C3orf68(gene name synonym) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656012|imex:IM-18725-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_872329.1|ensembl:ENSG00000187118(gene)|ensembl:ENST00000466830(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0046872"(metal ion binding)|interpro:IPR013892(Protein of unknown function UPF0287) refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 4F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:XLpcUQKNCUyL+bnDHXL5ibCYqLg9606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 intact-crc:27211F79D29218C5|rigid:6JDCgJkVKavoF7qGFuEhsZvuf58 false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:Q15526 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-3915286|uniprotkb:Q5T8T3|uniprotkb:Q5T8T4|ensembl:ENSP00000361042|ensembl:ENSP00000487158 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:surf1_human(display_long)|uniprotkb:SURF1(gene name)|psi-mi:SURF1(display_short)|uniprotkb:SURF-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570478|imex:IM-18725-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_003163.1|refseq:NP_001267716.1|ensembl:ENSG00000148290(gene)|ensembl:ENSG00000280627(gene)|ensembl:ENST00000371974(transcript)|ensembl:ENST00000626663(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR002994(Surfeit locus 1)|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Fig. 1E|comment:Minute amounts of COX1 were also coisolated|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:HGpXJhbeMdDuz7amqIgWqxlHicA9606 intact-crc:19C9B5C354804F8A|rigid:+QGVb3kmmrK+Myy/X53brubsg5o false - zz tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:P00395 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570524|imex:IM-18725-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 1G, 1I|comment:participants seperated both by SDS-PAGE and BN-PAGE|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 intact-crc:ABA8C6754173DB28|rigid:JNxBd9dqvmGCDbMHhYYMKQZY6E4 false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P00395 uniprotkb:Q9Y2R0 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656540|imex:IM-18725-28 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 intact-crc:DC6AE284D6CEC047|rigid:JNxBd9dqvmGCDbMHhYYMKQZY6E4 false - flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:Q9BSH4 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-747797|uniprotkb:Q8N3N6|uniprotkb:Q9UI60|uniprotkb:B2RD21|ensembl:ENSP00000258975 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:taco1_human(display_long)|uniprotkb:PRO0477(orf name)|uniprotkb:TACO1(gene name)|psi-mi:TACO1(display_short)|uniprotkb:CCDC44(gene name synonym)|uniprotkb:Translational activator of mitochondrially-encoded cytochrome c oxidase I(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 44(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570531|imex:IM-18725-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_057444.2|ensembl:ENSG00000136463(gene)|ensembl:ENST00000258975(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0019843"(rRNA binding)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0061743"(motor learning)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|interpro:IPR002876(Protein of unknown function DUF28)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR026564|interpro:IPR029072|mint:Q9BSH4|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 3A, 3D, Supp. Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:c/tu89NvCs3Kt8qO8e5F6hrywBo9606 intact-crc:035AF6351CDF9943|rigid:ZKB21f1dJk62A+4TRfh8aq0stNc false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:P00395 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570531|imex:IM-18725-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 3A, 3D, Supp. Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 intact-crc:035AF6351CDF9943|rigid:ZKB21f1dJk62A+4TRfh8aq0stNc false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:Q15526 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-3915286|uniprotkb:Q5T8T3|uniprotkb:Q5T8T4|ensembl:ENSP00000361042|ensembl:ENSP00000487158 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:surf1_human(display_long)|uniprotkb:SURF1(gene name)|psi-mi:SURF1(display_short)|uniprotkb:SURF-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570531|imex:IM-18725-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_003163.1|refseq:NP_001267716.1|ensembl:ENSG00000148290(gene)|ensembl:ENSG00000280627(gene)|ensembl:ENST00000371974(transcript)|ensembl:ENST00000626663(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR002994(Surfeit locus 1)|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 3A, 3D, Supp. Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:HGpXJhbeMdDuz7amqIgWqxlHicA9606 intact-crc:035AF6351CDF9943|rigid:ZKB21f1dJk62A+4TRfh8aq0stNc false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9GZY4 uniprotkb:P00395 intact:EBI-6570735|uniprotkb:A6NJU8|uniprotkb:A8KAH8|uniprotkb:Q9HAB7|uniprotkb:Q9NVD2|ensembl:ENSP00000223336|ensembl:ENSP00000312100|ensembl:ENSP00000379218|ensembl:ENSP00000395586|ensembl:ENSP00000400759|ensembl:ENSP00000413777|ensembl:ENSP00000416406 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:coa1_human(display_long)|uniprotkb:COA1(gene name)|psi-mi:COA1(display_short)|uniprotkb:C7orf44(gene name synonym)|uniprotkb:MITRAC15(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa(gene name synonym) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655974|imex:IM-18725-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060694.2|ensembl:ENSG00000106603(gene)|ensembl:ENST00000223336(transcript)|ensembl:ENST00000310564(transcript)|ensembl:ENST00000395879(transcript)|ensembl:ENST00000438444(transcript)|ensembl:ENST00000446330(transcript)|ensembl:ENST00000446564(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR014807(Protein of unknown function DUF1783, fungi)|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENST00000415076(transcript)|refseq:NP_001308126.1|refseq:NP_001308127.1|refseq:NP_001308128.1|refseq:NP_001308129.1|refseq:XP_005249864.1|refseq:XP_006715815.1|refseq:XP_016867903.1|refseq:XP_016867904.1|refseq:XP_016867905.1|refseq:XP_016867906.1|refseq:XP_016867907.1|refseq:XP_016867908.1|refseq:XP_016867910.1|refseq:XP_016867911.1|refseq:XP_016867912.1|refseq:XP_016867913.1|refseq:XP_016867914.1|refseq:XP_016867915.1|refseq:XP_016867916.1|refseq:XP_016867917.1|refseq:XP_016867918.1|refseq:XP_016867919.1|refseq:XP_016867920.1|refseq:XP_016867921.1 refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:PWeLYXohVbUfWMoW71tQZo6pLn89606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 intact-crc:1181C41F8166CD32|rigid:yJzEXPHv3NwAd4gSBmjKvCNR1sA false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9GZY4 uniprotkb:Q15526 intact:EBI-6570735|uniprotkb:A6NJU8|uniprotkb:A8KAH8|uniprotkb:Q9HAB7|uniprotkb:Q9NVD2|ensembl:ENSP00000223336|ensembl:ENSP00000312100|ensembl:ENSP00000379218|ensembl:ENSP00000395586|ensembl:ENSP00000400759|ensembl:ENSP00000413777|ensembl:ENSP00000416406 intact:EBI-3915286|uniprotkb:Q5T8T3|uniprotkb:Q5T8T4|ensembl:ENSP00000361042|ensembl:ENSP00000487158 psi-mi:coa1_human(display_long)|uniprotkb:COA1(gene name)|psi-mi:COA1(display_short)|uniprotkb:C7orf44(gene name synonym)|uniprotkb:MITRAC15(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa(gene name synonym) psi-mi:surf1_human(display_long)|uniprotkb:SURF1(gene name)|psi-mi:SURF1(display_short)|uniprotkb:SURF-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655974|imex:IM-18725-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060694.2|ensembl:ENSG00000106603(gene)|ensembl:ENST00000223336(transcript)|ensembl:ENST00000310564(transcript)|ensembl:ENST00000395879(transcript)|ensembl:ENST00000438444(transcript)|ensembl:ENST00000446330(transcript)|ensembl:ENST00000446564(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR014807(Protein of unknown function DUF1783, fungi)|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENST00000415076(transcript)|refseq:NP_001308126.1|refseq:NP_001308127.1|refseq:NP_001308128.1|refseq:NP_001308129.1|refseq:XP_005249864.1|refseq:XP_006715815.1|refseq:XP_016867903.1|refseq:XP_016867904.1|refseq:XP_016867905.1|refseq:XP_016867906.1|refseq:XP_016867907.1|refseq:XP_016867908.1|refseq:XP_016867910.1|refseq:XP_016867911.1|refseq:XP_016867912.1|refseq:XP_016867913.1|refseq:XP_016867914.1|refseq:XP_016867915.1|refseq:XP_016867916.1|refseq:XP_016867917.1|refseq:XP_016867918.1|refseq:XP_016867919.1|refseq:XP_016867920.1|refseq:XP_016867921.1 refseq:NP_003163.1|refseq:NP_001267716.1|ensembl:ENSG00000148290(gene)|ensembl:ENSG00000280627(gene)|ensembl:ENST00000371974(transcript)|ensembl:ENST00000626663(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR002994(Surfeit locus 1)|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:PWeLYXohVbUfWMoW71tQZo6pLn89606 rogid:HGpXJhbeMdDuz7amqIgWqxlHicA9606 intact-crc:1181C41F8166CD32|rigid:yJzEXPHv3NwAd4gSBmjKvCNR1sA false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9GZY4 uniprotkb:Q9Y2R0 intact:EBI-6570735|uniprotkb:A6NJU8|uniprotkb:A8KAH8|uniprotkb:Q9HAB7|uniprotkb:Q9NVD2|ensembl:ENSP00000223336|ensembl:ENSP00000312100|ensembl:ENSP00000379218|ensembl:ENSP00000395586|ensembl:ENSP00000400759|ensembl:ENSP00000413777|ensembl:ENSP00000416406 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 psi-mi:coa1_human(display_long)|uniprotkb:COA1(gene name)|psi-mi:COA1(display_short)|uniprotkb:C7orf44(gene name synonym)|uniprotkb:MITRAC15(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa(gene name synonym) psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655974|imex:IM-18725-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060694.2|ensembl:ENSG00000106603(gene)|ensembl:ENST00000223336(transcript)|ensembl:ENST00000310564(transcript)|ensembl:ENST00000395879(transcript)|ensembl:ENST00000438444(transcript)|ensembl:ENST00000446330(transcript)|ensembl:ENST00000446564(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR014807(Protein of unknown function DUF1783, fungi)|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENST00000415076(transcript)|refseq:NP_001308126.1|refseq:NP_001308127.1|refseq:NP_001308128.1|refseq:NP_001308129.1|refseq:XP_005249864.1|refseq:XP_006715815.1|refseq:XP_016867903.1|refseq:XP_016867904.1|refseq:XP_016867905.1|refseq:XP_016867906.1|refseq:XP_016867907.1|refseq:XP_016867908.1|refseq:XP_016867910.1|refseq:XP_016867911.1|refseq:XP_016867912.1|refseq:XP_016867913.1|refseq:XP_016867914.1|refseq:XP_016867915.1|refseq:XP_016867916.1|refseq:XP_016867917.1|refseq:XP_016867918.1|refseq:XP_016867919.1|refseq:XP_016867920.1|refseq:XP_016867921.1 refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 - - - figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:PWeLYXohVbUfWMoW71tQZo6pLn89606 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 intact-crc:1181C41F8166CD32|rigid:yJzEXPHv3NwAd4gSBmjKvCNR1sA false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9GZY4 uniprotkb:Q9BVV7 intact:EBI-6570735|uniprotkb:A6NJU8|uniprotkb:A8KAH8|uniprotkb:Q9HAB7|uniprotkb:Q9NVD2|ensembl:ENSP00000223336|ensembl:ENSP00000312100|ensembl:ENSP00000379218|ensembl:ENSP00000395586|ensembl:ENSP00000400759|ensembl:ENSP00000413777|ensembl:ENSP00000416406 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 psi-mi:coa1_human(display_long)|uniprotkb:COA1(gene name)|psi-mi:COA1(display_short)|uniprotkb:C7orf44(gene name synonym)|uniprotkb:MITRAC15(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa(gene name synonym) psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655974|imex:IM-18725-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060694.2|ensembl:ENSG00000106603(gene)|ensembl:ENST00000223336(transcript)|ensembl:ENST00000310564(transcript)|ensembl:ENST00000395879(transcript)|ensembl:ENST00000438444(transcript)|ensembl:ENST00000446330(transcript)|ensembl:ENST00000446564(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR014807(Protein of unknown function DUF1783, fungi)|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENST00000415076(transcript)|refseq:NP_001308126.1|refseq:NP_001308127.1|refseq:NP_001308128.1|refseq:NP_001308129.1|refseq:XP_005249864.1|refseq:XP_006715815.1|refseq:XP_016867903.1|refseq:XP_016867904.1|refseq:XP_016867905.1|refseq:XP_016867906.1|refseq:XP_016867907.1|refseq:XP_016867908.1|refseq:XP_016867910.1|refseq:XP_016867911.1|refseq:XP_016867912.1|refseq:XP_016867913.1|refseq:XP_016867914.1|refseq:XP_016867915.1|refseq:XP_016867916.1|refseq:XP_016867917.1|refseq:XP_016867918.1|refseq:XP_016867919.1|refseq:XP_016867920.1|refseq:XP_016867921.1 ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 - - - figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:PWeLYXohVbUfWMoW71tQZo6pLn89606 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 intact-crc:1181C41F8166CD32|rigid:yJzEXPHv3NwAd4gSBmjKvCNR1sA false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9GZY4 uniprotkb:O95169 intact:EBI-6570735|uniprotkb:A6NJU8|uniprotkb:A8KAH8|uniprotkb:Q9HAB7|uniprotkb:Q9NVD2|ensembl:ENSP00000223336|ensembl:ENSP00000312100|ensembl:ENSP00000379218|ensembl:ENSP00000395586|ensembl:ENSP00000400759|ensembl:ENSP00000413777|ensembl:ENSP00000416406 intact:EBI-716238|uniprotkb:Q5W144|uniprotkb:Q9UG53|uniprotkb:Q9UJR4|uniprotkb:Q9UQF3|uniprotkb:A8K0L4|intact:EBI-11021395|uniprotkb:Q5W143|uniprotkb:Q5W145|intact:EBI-28971189|ensembl:ENSP00000299166 psi-mi:coa1_human(display_long)|uniprotkb:COA1(gene name)|psi-mi:COA1(display_short)|uniprotkb:C7orf44(gene name synonym)|uniprotkb:MITRAC15(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa(gene name synonym) psi-mi:ndub8_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase ASHI subunit(gene name synonym)|uniprotkb:Complex I-ASHI(gene name synonym)|uniprotkb:NDUFB8(gene name)|psi-mi:NDUFB8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655974|imex:IM-18725-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060694.2|ensembl:ENSG00000106603(gene)|ensembl:ENST00000223336(transcript)|ensembl:ENST00000310564(transcript)|ensembl:ENST00000395879(transcript)|ensembl:ENST00000438444(transcript)|ensembl:ENST00000446330(transcript)|ensembl:ENST00000446564(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR014807(Protein of unknown function DUF1783, fungi)|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENST00000415076(transcript)|refseq:NP_001308126.1|refseq:NP_001308127.1|refseq:NP_001308128.1|refseq:NP_001308129.1|refseq:XP_005249864.1|refseq:XP_006715815.1|refseq:XP_016867903.1|refseq:XP_016867904.1|refseq:XP_016867905.1|refseq:XP_016867906.1|refseq:XP_016867907.1|refseq:XP_016867908.1|refseq:XP_016867910.1|refseq:XP_016867911.1|refseq:XP_016867912.1|refseq:XP_016867913.1|refseq:XP_016867914.1|refseq:XP_016867915.1|refseq:XP_016867916.1|refseq:XP_016867917.1|refseq:XP_016867918.1|refseq:XP_016867919.1|refseq:XP_016867920.1|refseq:XP_016867921.1 ensembl:ENSP00000299166|ensembl:ENST00000370320|ensembl:ENSP00000359344|ensembl:ENST00000370322|ensembl:ENSP00000359346|refseq:NP_004995.1|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-1268020|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008699(NADH-ubiquinone oxidoreductase ASHI subunit)|interpro:IPR016551("NADH dehydrogenase [ubiquinone] (complex I), beta subcomplex, subunit 8")|rcsb pdb:5XTC|rcsb pdb:5XTD|ensembl:ENSG00000166136(gene)|ensembl:ENST00000299166(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|refseq:NP_001271296.1|refseq:NP_001271297.1 - - - figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:PWeLYXohVbUfWMoW71tQZo6pLn89606 rogid:iHF93OOQynl/ZBrUOOp9sAbDZkw9606 intact-crc:1181C41F8166CD32|rigid:yJzEXPHv3NwAd4gSBmjKvCNR1sA false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q3ZCQ8 uniprotkb:O14925 intact:EBI-355175|uniprotkb:Q6QA00|uniprotkb:Q96FJ5|uniprotkb:Q96GY2|uniprotkb:Q9H370|intact:EBI-2554785|uniprotkb:Q330K1|ensembl:ENSP00000475531 intact:EBI-1047996|uniprotkb:Q53FF8|uniprotkb:Q6P5S5|uniprotkb:Q5T1E6|ensembl:ENSP00000464522 psi-mi:tim50_human(display_long)|uniprotkb:TIMM50(gene name)|psi-mi:TIMM50(display_short)|uniprotkb:TIM50(gene name synonym)|uniprotkb:PRO1512(orf name) psi-mi:tim23_human(display_long)|uniprotkb:TIMM23(gene name)|psi-mi:TIMM23(display_short)|uniprotkb:TIM23(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656485|imex:IM-18725-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001001563.1|ensembl:ENSG00000105197(gene)|ensembl:ENST00000607714(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0043021"(ribonucleoprotein complex binding)|interpro:IPR004274(NLI interacting factor)|interpro:IPR023214|interpro:IPR027111|interpro:IPR036412|mint:Q3ZCQ8|reactome:R-HSA-1268020|refseq:NP_001316488.1|dip:DIP-34058N refseq:NP_006318.1|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|interpro:IPR005681(Mitochondrial import inner membrane translocase, subunit Tim23)|mint:O14925|reactome:R-HSA-1268020|ensembl:ENSG00000265354(gene)|ensembl:ENST00000580018(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex) go:"GO:0005739"(mitochondrion) - - figure legend:Supp Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:fOPV33h12YhAq9jj0bVno01Q+6g9606 rogid:Hmu/kwfaPLGFGYBJH0oue7JDYqM9606 intact-crc:ADE13E4E6702255A|rigid:Y9e/eld1Vjtqyx94y8vEK27iVYU false - flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BVV7 uniprotkb:P00395 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656554|imex:IM-18725-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 7E, 7B.|comment:When the synthesis of mitochondria-encoded proteins was inhibited by thiamphenicol, the interaction of TIM21 with COX1 and MITRAC12 was strongly reduced without influencing the interaction with TIM23. Blocking cytosolic translation with emetine and concomitantly import of nuclear-encoded subunits reduced the interaction between TIM21 and TIM23, whereas the interaction with COX1 and MITRAC12 remained unaffected.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 intact-crc:20499F42F526D5A6|rigid:dWoWmC6SPWz12kC7huCpOZ/mA88 false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BVV7 uniprotkb:Q9Y2R0 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656554|imex:IM-18725-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 7E, 7B.|comment:When the synthesis of mitochondria-encoded proteins was inhibited by thiamphenicol, the interaction of TIM21 with COX1 and MITRAC12 was strongly reduced without influencing the interaction with TIM23. Blocking cytosolic translation with emetine and concomitantly import of nuclear-encoded subunits reduced the interaction between TIM21 and TIM23, whereas the interaction with COX1 and MITRAC12 remained unaffected.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 intact-crc:20499F42F526D5A6|rigid:dWoWmC6SPWz12kC7huCpOZ/mA88 false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BVV7 uniprotkb:Q9GZY4 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 intact:EBI-6570735|uniprotkb:A6NJU8|uniprotkb:A8KAH8|uniprotkb:Q9HAB7|uniprotkb:Q9NVD2|ensembl:ENSP00000223336|ensembl:ENSP00000312100|ensembl:ENSP00000379218|ensembl:ENSP00000395586|ensembl:ENSP00000400759|ensembl:ENSP00000413777|ensembl:ENSP00000416406 psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:coa1_human(display_long)|uniprotkb:COA1(gene name)|psi-mi:COA1(display_short)|uniprotkb:C7orf44(gene name synonym)|uniprotkb:MITRAC15(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656554|imex:IM-18725-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 refseq:NP_060694.2|ensembl:ENSG00000106603(gene)|ensembl:ENST00000223336(transcript)|ensembl:ENST00000310564(transcript)|ensembl:ENST00000395879(transcript)|ensembl:ENST00000438444(transcript)|ensembl:ENST00000446330(transcript)|ensembl:ENST00000446564(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR014807(Protein of unknown function DUF1783, fungi)|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENST00000415076(transcript)|refseq:NP_001308126.1|refseq:NP_001308127.1|refseq:NP_001308128.1|refseq:NP_001308129.1|refseq:XP_005249864.1|refseq:XP_006715815.1|refseq:XP_016867903.1|refseq:XP_016867904.1|refseq:XP_016867905.1|refseq:XP_016867906.1|refseq:XP_016867907.1|refseq:XP_016867908.1|refseq:XP_016867910.1|refseq:XP_016867911.1|refseq:XP_016867912.1|refseq:XP_016867913.1|refseq:XP_016867914.1|refseq:XP_016867915.1|refseq:XP_016867916.1|refseq:XP_016867917.1|refseq:XP_016867918.1|refseq:XP_016867919.1|refseq:XP_016867920.1|refseq:XP_016867921.1 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 7E, 7B.|comment:When the synthesis of mitochondria-encoded proteins was inhibited by thiamphenicol, the interaction of TIM21 with COX1 and MITRAC12 was strongly reduced without influencing the interaction with TIM23. Blocking cytosolic translation with emetine and concomitantly import of nuclear-encoded subunits reduced the interaction between TIM21 and TIM23, whereas the interaction with COX1 and MITRAC12 remained unaffected.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 rogid:PWeLYXohVbUfWMoW71tQZo6pLn89606 intact-crc:20499F42F526D5A6|rigid:dWoWmC6SPWz12kC7huCpOZ/mA88 false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BVV7 uniprotkb:O14925 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 intact:EBI-1047996|uniprotkb:Q53FF8|uniprotkb:Q6P5S5|uniprotkb:Q5T1E6|ensembl:ENSP00000464522 psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:tim23_human(display_long)|uniprotkb:TIMM23(gene name)|psi-mi:TIMM23(display_short)|uniprotkb:TIM23(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656554|imex:IM-18725-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 refseq:NP_006318.1|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|interpro:IPR005681(Mitochondrial import inner membrane translocase, subunit Tim23)|mint:O14925|reactome:R-HSA-1268020|ensembl:ENSG00000265354(gene)|ensembl:ENST00000580018(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex) go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 7E, 7B.|comment:When the synthesis of mitochondria-encoded proteins was inhibited by thiamphenicol, the interaction of TIM21 with COX1 and MITRAC12 was strongly reduced without influencing the interaction with TIM23. Blocking cytosolic translation with emetine and concomitantly import of nuclear-encoded subunits reduced the interaction between TIM21 and TIM23, whereas the interaction with COX1 and MITRAC12 remained unaffected.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 rogid:Hmu/kwfaPLGFGYBJH0oue7JDYqM9606 intact-crc:20499F42F526D5A6|rigid:dWoWmC6SPWz12kC7huCpOZ/mA88 false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O14925 uniprotkb:Q9BVV7 intact:EBI-1047996|uniprotkb:Q53FF8|uniprotkb:Q6P5S5|uniprotkb:Q5T1E6|ensembl:ENSP00000464522 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 psi-mi:tim23_human(display_long)|uniprotkb:TIMM23(gene name)|psi-mi:TIMM23(display_short)|uniprotkb:TIM23(gene name synonym) psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656269|imex:IM-18725-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006318.1|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|interpro:IPR005681(Mitochondrial import inner membrane translocase, subunit Tim23)|mint:O14925|reactome:R-HSA-1268020|ensembl:ENSG00000265354(gene)|ensembl:ENST00000580018(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex) ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:Hmu/kwfaPLGFGYBJH0oue7JDYqM9606 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 intact-crc:3EC70D63B35846EA|rigid:EerYKd6lVuiApIuhBIfayEATp8M false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BVV7 uniprotkb:Q3ZCQ8 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 intact:EBI-355175|uniprotkb:Q6QA00|uniprotkb:Q96FJ5|uniprotkb:Q96GY2|uniprotkb:Q9H370|intact:EBI-2554785|uniprotkb:Q330K1|ensembl:ENSP00000475531 psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:tim50_human(display_long)|uniprotkb:TIMM50(gene name)|psi-mi:TIMM50(display_short)|uniprotkb:TIM50(gene name synonym)|uniprotkb:PRO1512(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656507|imex:IM-18725-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 refseq:NP_001001563.1|ensembl:ENSG00000105197(gene)|ensembl:ENST00000607714(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0043021"(ribonucleoprotein complex binding)|interpro:IPR004274(NLI interacting factor)|interpro:IPR023214|interpro:IPR027111|interpro:IPR036412|mint:Q3ZCQ8|reactome:R-HSA-1268020|refseq:NP_001316488.1|dip:DIP-34058N go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 rogid:fOPV33h12YhAq9jj0bVno01Q+6g9606 intact-crc:24E8CEF8593F3B23|rigid:WId4Gw5m7SxjXl0dJixCHsh6AIA false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BVV7 uniprotkb:P00395 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656507|imex:IM-18725-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 intact-crc:24E8CEF8593F3B23|rigid:WId4Gw5m7SxjXl0dJixCHsh6AIA false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BVV7 uniprotkb:Q9Y2R0 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656507|imex:IM-18725-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 intact-crc:24E8CEF8593F3B23|rigid:WId4Gw5m7SxjXl0dJixCHsh6AIA false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BVV7 uniprotkb:O95169 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 intact:EBI-716238|uniprotkb:Q5W144|uniprotkb:Q9UG53|uniprotkb:Q9UJR4|uniprotkb:Q9UQF3|uniprotkb:A8K0L4|intact:EBI-11021395|uniprotkb:Q5W143|uniprotkb:Q5W145|intact:EBI-28971189|ensembl:ENSP00000299166 psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:ndub8_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase ASHI subunit(gene name synonym)|uniprotkb:Complex I-ASHI(gene name synonym)|uniprotkb:NDUFB8(gene name)|psi-mi:NDUFB8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656507|imex:IM-18725-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 ensembl:ENSP00000299166|ensembl:ENST00000370320|ensembl:ENSP00000359344|ensembl:ENST00000370322|ensembl:ENSP00000359346|refseq:NP_004995.1|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-1268020|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008699(NADH-ubiquinone oxidoreductase ASHI subunit)|interpro:IPR016551("NADH dehydrogenase [ubiquinone] (complex I), beta subcomplex, subunit 8")|rcsb pdb:5XTC|rcsb pdb:5XTD|ensembl:ENSG00000166136(gene)|ensembl:ENST00000299166(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|refseq:NP_001271296.1|refseq:NP_001271297.1 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 rogid:iHF93OOQynl/ZBrUOOp9sAbDZkw9606 intact-crc:24E8CEF8593F3B23|rigid:WId4Gw5m7SxjXl0dJixCHsh6AIA false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BVV7 uniprotkb:P13073 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656507|imex:IM-18725-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 intact-crc:24E8CEF8593F3B23|rigid:WId4Gw5m7SxjXl0dJixCHsh6AIA false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BVV7 uniprotkb:O14925 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 intact:EBI-1047996|uniprotkb:Q53FF8|uniprotkb:Q6P5S5|uniprotkb:Q5T1E6|ensembl:ENSP00000464522 psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:tim23_human(display_long)|uniprotkb:TIMM23(gene name)|psi-mi:TIMM23(display_short)|uniprotkb:TIM23(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656507|imex:IM-18725-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 refseq:NP_006318.1|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|interpro:IPR005681(Mitochondrial import inner membrane translocase, subunit Tim23)|mint:O14925|reactome:R-HSA-1268020|ensembl:ENSG00000265354(gene)|ensembl:ENST00000580018(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex) go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 rogid:Hmu/kwfaPLGFGYBJH0oue7JDYqM9606 intact-crc:24E8CEF8593F3B23|rigid:WId4Gw5m7SxjXl0dJixCHsh6AIA false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BVV7 uniprotkb:P00395 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656548|imex:IM-18725-29 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Fig. 7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 intact-crc:863F5ECA56195F4D|rigid:3UqCtezmJCiwVCf7WKbbYyxSYYQ false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BVV7 uniprotkb:Q9GZY4 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 intact:EBI-6570735|uniprotkb:A6NJU8|uniprotkb:A8KAH8|uniprotkb:Q9HAB7|uniprotkb:Q9NVD2|ensembl:ENSP00000223336|ensembl:ENSP00000312100|ensembl:ENSP00000379218|ensembl:ENSP00000395586|ensembl:ENSP00000400759|ensembl:ENSP00000413777|ensembl:ENSP00000416406 psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:coa1_human(display_long)|uniprotkb:COA1(gene name)|psi-mi:COA1(display_short)|uniprotkb:C7orf44(gene name synonym)|uniprotkb:MITRAC15(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656418|imex:IM-18725-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 refseq:NP_060694.2|ensembl:ENSG00000106603(gene)|ensembl:ENST00000223336(transcript)|ensembl:ENST00000310564(transcript)|ensembl:ENST00000395879(transcript)|ensembl:ENST00000438444(transcript)|ensembl:ENST00000446330(transcript)|ensembl:ENST00000446564(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR014807(Protein of unknown function DUF1783, fungi)|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENST00000415076(transcript)|refseq:NP_001308126.1|refseq:NP_001308127.1|refseq:NP_001308128.1|refseq:NP_001308129.1|refseq:XP_005249864.1|refseq:XP_006715815.1|refseq:XP_016867903.1|refseq:XP_016867904.1|refseq:XP_016867905.1|refseq:XP_016867906.1|refseq:XP_016867907.1|refseq:XP_016867908.1|refseq:XP_016867910.1|refseq:XP_016867911.1|refseq:XP_016867912.1|refseq:XP_016867913.1|refseq:XP_016867914.1|refseq:XP_016867915.1|refseq:XP_016867916.1|refseq:XP_016867917.1|refseq:XP_016867918.1|refseq:XP_016867919.1|refseq:XP_016867920.1|refseq:XP_016867921.1 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 rogid:PWeLYXohVbUfWMoW71tQZo6pLn89606 intact-crc:A88E38FC35A38D4D|rigid:nesswEOIOHa6X1LpzFH8KpH/4vQ false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BVV7 uniprotkb:Q9Y2R0 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656418|imex:IM-18725-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 intact-crc:A88E38FC35A38D4D|rigid:nesswEOIOHa6X1LpzFH8KpH/4vQ false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P09669 uniprotkb:Q02221 intact:EBI-715040|uniprotkb:B2R4D7|ensembl:ENSP00000297564|ensembl:ENSP00000428150|ensembl:ENSP00000428702|ensembl:ENSP00000428895|ensembl:ENSP00000428965|ensembl:ENSP00000429410|ensembl:ENSP00000429707|ensembl:ENSP00000429714|ensembl:ENSP00000429755|ensembl:ENSP00000429991 intact:EBI-3907627|uniprotkb:Q6GTW6|uniprotkb:O00761|ensembl:ENSP00000287490 psi-mi:cox6c_human(display_long)|uniprotkb:COX6C(gene name)|psi-mi:COX6C(display_short)|uniprotkb:Cytochrome c oxidase polypeptide VIc(gene name synonym) psi-mi:cx6a2_human(display_long)|uniprotkb:COX6A2(gene name)|psi-mi:COX6A2(display_short)|uniprotkb:COX6A(gene name synonym)|uniprotkb:COX6AH(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide VIa-heart(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIA-muscle(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656517|imex:IM-18725-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004365.1|refseq:XP_016868509.1|ensembl:ENSG00000164919(gene)|ensembl:ENST00000297564(transcript)|ensembl:ENST00000517682(transcript)|ensembl:ENST00000518171(transcript)|ensembl:ENST00000520271(transcript)|ensembl:ENST00000520468(transcript)|ensembl:ENST00000520517(transcript)|ensembl:ENST00000522934(transcript)|ensembl:ENST00000522940(transcript)|ensembl:ENST00000523016(transcript)|ensembl:ENST00000524245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004204(Cytochrome c oxidase subunit VIc)|interpro:IPR034884|interpro:IPR037169|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0006091"(generation of precursor metabolites and energy) refseq:NP_005196.1|ensembl:ENSG00000156885(gene)|ensembl:ENST00000287490(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030234"(enzyme regulator activity)|interpro:IPR001349(Cytochrome c oxidase, subunit VIa)|interpro:IPR018507|interpro:IPR036418 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:Zha4dqasvkWw3ACebJNflgxCVKo9606 rogid:Np4BxYvAowYaVaX4ey8P/dktp449606 intact-crc:0B197A3B2E7761C4|rigid:nyDelf/BqKVdAGyq+lgVWnLiXkg false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P09669 uniprotkb:P47985 intact:EBI-715040|uniprotkb:B2R4D7|ensembl:ENSP00000297564|ensembl:ENSP00000428150|ensembl:ENSP00000428702|ensembl:ENSP00000428895|ensembl:ENSP00000428965|ensembl:ENSP00000429410|ensembl:ENSP00000429707|ensembl:ENSP00000429714|ensembl:ENSP00000429755|ensembl:ENSP00000429991 intact:EBI-1045520|uniprotkb:Q6NVX5|uniprotkb:Q9UPH2|uniprotkb:A8K519|ensembl:ENSP00000306397 psi-mi:cox6c_human(display_long)|uniprotkb:COX6C(gene name)|psi-mi:COX6C(display_short)|uniprotkb:Cytochrome c oxidase polypeptide VIc(gene name synonym) psi-mi:ucri_human(display_long)|uniprotkb:Ubiquinol-cytochrome c reductase iron-sulfur subunit(gene name synonym)|uniprotkb:Rieske iron-sulfur protein(gene name synonym)|uniprotkb:Complex III subunit 5(gene name synonym)|uniprotkb:Rieske protein UQCRFS1(gene name synonym)|uniprotkb:UQCRFS1(gene name)|psi-mi:UQCRFS1(display_short)|uniprotkb:Cytochrome b-c1 complex subunit 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656517|imex:IM-18725-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004365.1|refseq:XP_016868509.1|ensembl:ENSG00000164919(gene)|ensembl:ENST00000297564(transcript)|ensembl:ENST00000517682(transcript)|ensembl:ENST00000518171(transcript)|ensembl:ENST00000520271(transcript)|ensembl:ENST00000520468(transcript)|ensembl:ENST00000520517(transcript)|ensembl:ENST00000522934(transcript)|ensembl:ENST00000522940(transcript)|ensembl:ENST00000523016(transcript)|ensembl:ENST00000524245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004204(Cytochrome c oxidase subunit VIc)|interpro:IPR034884|interpro:IPR037169|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0006091"(generation of precursor metabolites and energy) refseq:NP_005994.2|ensembl:ENSG00000169021(gene)|ensembl:ENST00000304863(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|interpro:IPR004192(Ubiquinol cytochrome reductase transmembrane region)|interpro:IPR005805(Rieske iron-sulphur protein, C-terminal)|interpro:IPR006317(Ubiquinol-cytochrome c reductase, iron-sulphur subunit)|interpro:IPR011070(Globular protein, non-globular alpha/beta subunit)|interpro:IPR014349(Rieske iron-sulphur protein)|interpro:IPR015248(Ubiquinol-cytochrome c reductase 8 kDa, N-terminal)|interpro:IPR017941|interpro:IPR036922|interpro:IPR037008|mint:P47985|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:Zha4dqasvkWw3ACebJNflgxCVKo9606 rogid:uBXz1yLEfiKg0/8rti+BnA5G9Nk9606 intact-crc:0B197A3B2E7761C4|rigid:nyDelf/BqKVdAGyq+lgVWnLiXkg false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P09669 uniprotkb:Q9BVV7 intact:EBI-715040|uniprotkb:B2R4D7|ensembl:ENSP00000297564|ensembl:ENSP00000428150|ensembl:ENSP00000428702|ensembl:ENSP00000428895|ensembl:ENSP00000428965|ensembl:ENSP00000429410|ensembl:ENSP00000429707|ensembl:ENSP00000429714|ensembl:ENSP00000429755|ensembl:ENSP00000429991 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 psi-mi:cox6c_human(display_long)|uniprotkb:COX6C(gene name)|psi-mi:COX6C(display_short)|uniprotkb:Cytochrome c oxidase polypeptide VIc(gene name synonym) psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656517|imex:IM-18725-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004365.1|refseq:XP_016868509.1|ensembl:ENSG00000164919(gene)|ensembl:ENST00000297564(transcript)|ensembl:ENST00000517682(transcript)|ensembl:ENST00000518171(transcript)|ensembl:ENST00000520271(transcript)|ensembl:ENST00000520468(transcript)|ensembl:ENST00000520517(transcript)|ensembl:ENST00000522934(transcript)|ensembl:ENST00000522940(transcript)|ensembl:ENST00000523016(transcript)|ensembl:ENST00000524245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004204(Cytochrome c oxidase subunit VIc)|interpro:IPR034884|interpro:IPR037169|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0006091"(generation of precursor metabolites and energy) ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:Zha4dqasvkWw3ACebJNflgxCVKo9606 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 intact-crc:0B197A3B2E7761C4|rigid:nyDelf/BqKVdAGyq+lgVWnLiXkg false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P09669 uniprotkb:P00395 intact:EBI-715040|uniprotkb:B2R4D7|ensembl:ENSP00000297564|ensembl:ENSP00000428150|ensembl:ENSP00000428702|ensembl:ENSP00000428895|ensembl:ENSP00000428965|ensembl:ENSP00000429410|ensembl:ENSP00000429707|ensembl:ENSP00000429714|ensembl:ENSP00000429755|ensembl:ENSP00000429991 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:cox6c_human(display_long)|uniprotkb:COX6C(gene name)|psi-mi:COX6C(display_short)|uniprotkb:Cytochrome c oxidase polypeptide VIc(gene name synonym) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656517|imex:IM-18725-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004365.1|refseq:XP_016868509.1|ensembl:ENSG00000164919(gene)|ensembl:ENST00000297564(transcript)|ensembl:ENST00000517682(transcript)|ensembl:ENST00000518171(transcript)|ensembl:ENST00000520271(transcript)|ensembl:ENST00000520468(transcript)|ensembl:ENST00000520517(transcript)|ensembl:ENST00000522934(transcript)|ensembl:ENST00000522940(transcript)|ensembl:ENST00000523016(transcript)|ensembl:ENST00000524245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004204(Cytochrome c oxidase subunit VIc)|interpro:IPR034884|interpro:IPR037169|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0006091"(generation of precursor metabolites and energy) refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:Zha4dqasvkWw3ACebJNflgxCVKo9606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 intact-crc:0B197A3B2E7761C4|rigid:nyDelf/BqKVdAGyq+lgVWnLiXkg false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P09669 uniprotkb:Q15526 intact:EBI-715040|uniprotkb:B2R4D7|ensembl:ENSP00000297564|ensembl:ENSP00000428150|ensembl:ENSP00000428702|ensembl:ENSP00000428895|ensembl:ENSP00000428965|ensembl:ENSP00000429410|ensembl:ENSP00000429707|ensembl:ENSP00000429714|ensembl:ENSP00000429755|ensembl:ENSP00000429991 intact:EBI-3915286|uniprotkb:Q5T8T3|uniprotkb:Q5T8T4|ensembl:ENSP00000361042|ensembl:ENSP00000487158 psi-mi:cox6c_human(display_long)|uniprotkb:COX6C(gene name)|psi-mi:COX6C(display_short)|uniprotkb:Cytochrome c oxidase polypeptide VIc(gene name synonym) psi-mi:surf1_human(display_long)|uniprotkb:SURF1(gene name)|psi-mi:SURF1(display_short)|uniprotkb:SURF-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656517|imex:IM-18725-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004365.1|refseq:XP_016868509.1|ensembl:ENSG00000164919(gene)|ensembl:ENST00000297564(transcript)|ensembl:ENST00000517682(transcript)|ensembl:ENST00000518171(transcript)|ensembl:ENST00000520271(transcript)|ensembl:ENST00000520468(transcript)|ensembl:ENST00000520517(transcript)|ensembl:ENST00000522934(transcript)|ensembl:ENST00000522940(transcript)|ensembl:ENST00000523016(transcript)|ensembl:ENST00000524245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004204(Cytochrome c oxidase subunit VIc)|interpro:IPR034884|interpro:IPR037169|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0006091"(generation of precursor metabolites and energy) refseq:NP_003163.1|refseq:NP_001267716.1|ensembl:ENSG00000148290(gene)|ensembl:ENSG00000280627(gene)|ensembl:ENST00000371974(transcript)|ensembl:ENST00000626663(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR002994(Surfeit locus 1)|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:Zha4dqasvkWw3ACebJNflgxCVKo9606 rogid:HGpXJhbeMdDuz7amqIgWqxlHicA9606 intact-crc:0B197A3B2E7761C4|rigid:nyDelf/BqKVdAGyq+lgVWnLiXkg false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P09669 uniprotkb:Q9Y2R0 intact:EBI-715040|uniprotkb:B2R4D7|ensembl:ENSP00000297564|ensembl:ENSP00000428150|ensembl:ENSP00000428702|ensembl:ENSP00000428895|ensembl:ENSP00000428965|ensembl:ENSP00000429410|ensembl:ENSP00000429707|ensembl:ENSP00000429714|ensembl:ENSP00000429755|ensembl:ENSP00000429991 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 psi-mi:cox6c_human(display_long)|uniprotkb:COX6C(gene name)|psi-mi:COX6C(display_short)|uniprotkb:Cytochrome c oxidase polypeptide VIc(gene name synonym) psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656517|imex:IM-18725-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004365.1|refseq:XP_016868509.1|ensembl:ENSG00000164919(gene)|ensembl:ENST00000297564(transcript)|ensembl:ENST00000517682(transcript)|ensembl:ENST00000518171(transcript)|ensembl:ENST00000520271(transcript)|ensembl:ENST00000520468(transcript)|ensembl:ENST00000520517(transcript)|ensembl:ENST00000522934(transcript)|ensembl:ENST00000522940(transcript)|ensembl:ENST00000523016(transcript)|ensembl:ENST00000524245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004204(Cytochrome c oxidase subunit VIc)|interpro:IPR034884|interpro:IPR037169|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0006091"(generation of precursor metabolites and energy) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:Zha4dqasvkWw3ACebJNflgxCVKo9606 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 intact-crc:0B197A3B2E7761C4|rigid:nyDelf/BqKVdAGyq+lgVWnLiXkg false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P09669 uniprotkb:O95169 intact:EBI-715040|uniprotkb:B2R4D7|ensembl:ENSP00000297564|ensembl:ENSP00000428150|ensembl:ENSP00000428702|ensembl:ENSP00000428895|ensembl:ENSP00000428965|ensembl:ENSP00000429410|ensembl:ENSP00000429707|ensembl:ENSP00000429714|ensembl:ENSP00000429755|ensembl:ENSP00000429991 intact:EBI-716238|uniprotkb:Q5W144|uniprotkb:Q9UG53|uniprotkb:Q9UJR4|uniprotkb:Q9UQF3|uniprotkb:A8K0L4|intact:EBI-11021395|uniprotkb:Q5W143|uniprotkb:Q5W145|intact:EBI-28971189|ensembl:ENSP00000299166 psi-mi:cox6c_human(display_long)|uniprotkb:COX6C(gene name)|psi-mi:COX6C(display_short)|uniprotkb:Cytochrome c oxidase polypeptide VIc(gene name synonym) psi-mi:ndub8_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase ASHI subunit(gene name synonym)|uniprotkb:Complex I-ASHI(gene name synonym)|uniprotkb:NDUFB8(gene name)|psi-mi:NDUFB8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656517|imex:IM-18725-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004365.1|refseq:XP_016868509.1|ensembl:ENSG00000164919(gene)|ensembl:ENST00000297564(transcript)|ensembl:ENST00000517682(transcript)|ensembl:ENST00000518171(transcript)|ensembl:ENST00000520271(transcript)|ensembl:ENST00000520468(transcript)|ensembl:ENST00000520517(transcript)|ensembl:ENST00000522934(transcript)|ensembl:ENST00000522940(transcript)|ensembl:ENST00000523016(transcript)|ensembl:ENST00000524245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004204(Cytochrome c oxidase subunit VIc)|interpro:IPR034884|interpro:IPR037169|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0006091"(generation of precursor metabolites and energy) ensembl:ENSP00000299166|ensembl:ENST00000370320|ensembl:ENSP00000359344|ensembl:ENST00000370322|ensembl:ENSP00000359346|refseq:NP_004995.1|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-1268020|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008699(NADH-ubiquinone oxidoreductase ASHI subunit)|interpro:IPR016551("NADH dehydrogenase [ubiquinone] (complex I), beta subcomplex, subunit 8")|rcsb pdb:5XTC|rcsb pdb:5XTD|ensembl:ENSG00000166136(gene)|ensembl:ENST00000299166(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|refseq:NP_001271296.1|refseq:NP_001271297.1 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:Zha4dqasvkWw3ACebJNflgxCVKo9606 rogid:iHF93OOQynl/ZBrUOOp9sAbDZkw9606 intact-crc:0B197A3B2E7761C4|rigid:nyDelf/BqKVdAGyq+lgVWnLiXkg false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P09669 uniprotkb:P20674 intact:EBI-715040|uniprotkb:B2R4D7|ensembl:ENSP00000297564|ensembl:ENSP00000428150|ensembl:ENSP00000428702|ensembl:ENSP00000428895|ensembl:ENSP00000428965|ensembl:ENSP00000429410|ensembl:ENSP00000429707|ensembl:ENSP00000429714|ensembl:ENSP00000429755|ensembl:ENSP00000429991 intact:EBI-715032|uniprotkb:P30045|intact:EBI-1043629|uniprotkb:Q8TB65|ensembl:ENSP00000317780|ensembl:ENSP00000456386 psi-mi:cox6c_human(display_long)|uniprotkb:COX6C(gene name)|psi-mi:COX6C(display_short)|uniprotkb:Cytochrome c oxidase polypeptide VIc(gene name synonym) psi-mi:cox5a_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Va(gene name synonym)|uniprotkb:COX5A(gene name)|psi-mi:COX5A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656517|imex:IM-18725-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004365.1|refseq:XP_016868509.1|ensembl:ENSG00000164919(gene)|ensembl:ENST00000297564(transcript)|ensembl:ENST00000517682(transcript)|ensembl:ENST00000518171(transcript)|ensembl:ENST00000520271(transcript)|ensembl:ENST00000520468(transcript)|ensembl:ENST00000520517(transcript)|ensembl:ENST00000522934(transcript)|ensembl:ENST00000522940(transcript)|ensembl:ENST00000523016(transcript)|ensembl:ENST00000524245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004204(Cytochrome c oxidase subunit VIc)|interpro:IPR034884|interpro:IPR037169|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0006091"(generation of precursor metabolites and energy) refseq:NP_004246.2|interpro:IPR003204(Cytochrome c oxidase, subunit Va)|interpro:IPR036545|mint:P20674|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000178741(gene)|ensembl:ENST00000322347(transcript)|ensembl:ENST00000564811(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity) go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:Zha4dqasvkWw3ACebJNflgxCVKo9606 rogid:dWvZKYawyJQwN29Mhkm44DXXqhg9606 intact-crc:0B197A3B2E7761C4|rigid:nyDelf/BqKVdAGyq+lgVWnLiXkg false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q02221 uniprotkb:Q16795 intact:EBI-3907627|uniprotkb:Q6GTW6|uniprotkb:O00761|ensembl:ENSP00000287490 intact:EBI-1045087|uniprotkb:Q14076|uniprotkb:Q2NKX0|ensembl:ENSP00000266544 psi-mi:cx6a2_human(display_long)|uniprotkb:COX6A2(gene name)|psi-mi:COX6A2(display_short)|uniprotkb:COX6A(gene name synonym)|uniprotkb:COX6AH(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide VIa-heart(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIA-muscle(gene name synonym) psi-mi:ndua9_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 39 kDa subunit(gene name synonym)|uniprotkb:Complex I-39kD(gene name synonym)|uniprotkb:NDUFA9(gene name)|psi-mi:NDUFA9(display_short)|uniprotkb:NDUFS2L(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656530|imex:IM-18725-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005196.1|ensembl:ENSG00000156885(gene)|ensembl:ENST00000287490(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030234"(enzyme regulator activity)|interpro:IPR001349(Cytochrome c oxidase, subunit VIa)|interpro:IPR018507|interpro:IPR036418 refseq:NP_004993.1|ensembl:ENSG00000139180(gene)|ensembl:ENST00000266544(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009749"(response to glucose)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1901006"(ubiquinone-6 biosynthetic process)|interpro:IPR001509(NAD-dependent epimerase/dehydratase)|interpro:IPR036291|mint:Q16795|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|dip:DIP-38526N go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:Np4BxYvAowYaVaX4ey8P/dktp449606 rogid:eM2zUsbdjMEILIcUedVOyEMwAzU9606 intact-crc:F8CC30A80219ADDC|rigid:Y74bgVfQ2E2NLkSOg2fLPWQ3ZWY false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q02221 uniprotkb:Q9Y2R0 intact:EBI-3907627|uniprotkb:Q6GTW6|uniprotkb:O00761|ensembl:ENSP00000287490 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 psi-mi:cx6a2_human(display_long)|uniprotkb:COX6A2(gene name)|psi-mi:COX6A2(display_short)|uniprotkb:COX6A(gene name synonym)|uniprotkb:COX6AH(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide VIa-heart(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIA-muscle(gene name synonym) psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656530|imex:IM-18725-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005196.1|ensembl:ENSG00000156885(gene)|ensembl:ENST00000287490(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030234"(enzyme regulator activity)|interpro:IPR001349(Cytochrome c oxidase, subunit VIa)|interpro:IPR018507|interpro:IPR036418 refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:Np4BxYvAowYaVaX4ey8P/dktp449606 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 intact-crc:F8CC30A80219ADDC|rigid:Y74bgVfQ2E2NLkSOg2fLPWQ3ZWY false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q02221 uniprotkb:P13073 intact:EBI-3907627|uniprotkb:Q6GTW6|uniprotkb:O00761|ensembl:ENSP00000287490 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:cx6a2_human(display_long)|uniprotkb:COX6A2(gene name)|psi-mi:COX6A2(display_short)|uniprotkb:COX6A(gene name synonym)|uniprotkb:COX6AH(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide VIa-heart(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIA-muscle(gene name synonym) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656530|imex:IM-18725-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005196.1|ensembl:ENSG00000156885(gene)|ensembl:ENST00000287490(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030234"(enzyme regulator activity)|interpro:IPR001349(Cytochrome c oxidase, subunit VIa)|interpro:IPR018507|interpro:IPR036418 refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:Np4BxYvAowYaVaX4ey8P/dktp449606 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 intact-crc:F8CC30A80219ADDC|rigid:Y74bgVfQ2E2NLkSOg2fLPWQ3ZWY false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q02221 uniprotkb:P20674 intact:EBI-3907627|uniprotkb:Q6GTW6|uniprotkb:O00761|ensembl:ENSP00000287490 intact:EBI-715032|uniprotkb:P30045|intact:EBI-1043629|uniprotkb:Q8TB65|ensembl:ENSP00000317780|ensembl:ENSP00000456386 psi-mi:cx6a2_human(display_long)|uniprotkb:COX6A2(gene name)|psi-mi:COX6A2(display_short)|uniprotkb:COX6A(gene name synonym)|uniprotkb:COX6AH(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide VIa-heart(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIA-muscle(gene name synonym) psi-mi:cox5a_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Va(gene name synonym)|uniprotkb:COX5A(gene name)|psi-mi:COX5A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656530|imex:IM-18725-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005196.1|ensembl:ENSG00000156885(gene)|ensembl:ENST00000287490(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030234"(enzyme regulator activity)|interpro:IPR001349(Cytochrome c oxidase, subunit VIa)|interpro:IPR018507|interpro:IPR036418 refseq:NP_004246.2|interpro:IPR003204(Cytochrome c oxidase, subunit Va)|interpro:IPR036545|mint:P20674|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000178741(gene)|ensembl:ENST00000322347(transcript)|ensembl:ENST00000564811(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity) go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:Np4BxYvAowYaVaX4ey8P/dktp449606 rogid:dWvZKYawyJQwN29Mhkm44DXXqhg9606 intact-crc:F8CC30A80219ADDC|rigid:Y74bgVfQ2E2NLkSOg2fLPWQ3ZWY false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q02221 uniprotkb:P00395 intact:EBI-3907627|uniprotkb:Q6GTW6|uniprotkb:O00761|ensembl:ENSP00000287490 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:cx6a2_human(display_long)|uniprotkb:COX6A2(gene name)|psi-mi:COX6A2(display_short)|uniprotkb:COX6A(gene name synonym)|uniprotkb:COX6AH(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide VIa-heart(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIA-muscle(gene name synonym) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656530|imex:IM-18725-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005196.1|ensembl:ENSG00000156885(gene)|ensembl:ENST00000287490(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030234"(enzyme regulator activity)|interpro:IPR001349(Cytochrome c oxidase, subunit VIa)|interpro:IPR018507|interpro:IPR036418 refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 6F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:Np4BxYvAowYaVaX4ey8P/dktp449606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 intact-crc:F8CC30A80219ADDC|rigid:Y74bgVfQ2E2NLkSOg2fLPWQ3ZWY false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:Q15526 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-3915286|uniprotkb:Q5T8T3|uniprotkb:Q5T8T4|ensembl:ENSP00000361042|ensembl:ENSP00000487158 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:surf1_human(display_long)|uniprotkb:SURF1(gene name)|psi-mi:SURF1(display_short)|uniprotkb:SURF-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570445|imex:IM-18725-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_003163.1|refseq:NP_001267716.1|ensembl:ENSG00000148290(gene)|ensembl:ENSG00000280627(gene)|ensembl:ENST00000371974(transcript)|ensembl:ENST00000626663(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR002994(Surfeit locus 1)|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:HGpXJhbeMdDuz7amqIgWqxlHicA9606 intact-crc:6B7BB1183F939016|rigid:+QGVb3kmmrK+Myy/X53brubsg5o false - zz tag:c-c - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:P00403 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:NyMmciQe53E935KEZahz8cGPjIM9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q7Z434 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:P00414 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-3932264|uniprotkb:Q14Y83|ensembl:ENSP00000354982 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox3_human(display_long)|uniprotkb:MT-CO3(gene name)|psi-mi:MT-CO3(display_short)|uniprotkb:COIII(gene name synonym)|uniprotkb:COXIII(gene name synonym)|uniprotkb:MTCO3(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide III(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 ensembl:ENSG00000198938(gene)|ensembl:ENST00000362079(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015453"(oxidoreduction-driven active transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045277"(respiratory chain complex IV)|interpro:IPR000298(Cytochrome c oxidase, subunit III)|interpro:IPR013833(Cytochrome c oxidase, subunit III, 4-helical bundle)|interpro:IPR024791|interpro:IPR033945|interpro:IPR035973|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|refseq:YP_003024032.1 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:ZsGHu+XXEfFZZecGf4EIhwQejAA9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q9GZY4 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6570735|uniprotkb:A6NJU8|uniprotkb:A8KAH8|uniprotkb:Q9HAB7|uniprotkb:Q9NVD2|ensembl:ENSP00000223336|ensembl:ENSP00000312100|ensembl:ENSP00000379218|ensembl:ENSP00000395586|ensembl:ENSP00000400759|ensembl:ENSP00000413777|ensembl:ENSP00000416406 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:coa1_human(display_long)|uniprotkb:COA1(gene name)|psi-mi:COA1(display_short)|uniprotkb:C7orf44(gene name synonym)|uniprotkb:MITRAC15(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_060694.2|ensembl:ENSG00000106603(gene)|ensembl:ENST00000223336(transcript)|ensembl:ENST00000310564(transcript)|ensembl:ENST00000395879(transcript)|ensembl:ENST00000438444(transcript)|ensembl:ENST00000446330(transcript)|ensembl:ENST00000446564(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR014807(Protein of unknown function DUF1783, fungi)|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENST00000415076(transcript)|refseq:NP_001308126.1|refseq:NP_001308127.1|refseq:NP_001308128.1|refseq:NP_001308129.1|refseq:XP_005249864.1|refseq:XP_006715815.1|refseq:XP_016867903.1|refseq:XP_016867904.1|refseq:XP_016867905.1|refseq:XP_016867906.1|refseq:XP_016867907.1|refseq:XP_016867908.1|refseq:XP_016867910.1|refseq:XP_016867911.1|refseq:XP_016867912.1|refseq:XP_016867913.1|refseq:XP_016867914.1|refseq:XP_016867915.1|refseq:XP_016867916.1|refseq:XP_016867917.1|refseq:XP_016867918.1|refseq:XP_016867919.1|refseq:XP_016867920.1|refseq:XP_016867921.1 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:PWeLYXohVbUfWMoW71tQZo6pLn89606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:P20674 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-715032|uniprotkb:P30045|intact:EBI-1043629|uniprotkb:Q8TB65|ensembl:ENSP00000317780|ensembl:ENSP00000456386 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox5a_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Va(gene name synonym)|uniprotkb:COX5A(gene name)|psi-mi:COX5A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_004246.2|interpro:IPR003204(Cytochrome c oxidase, subunit Va)|interpro:IPR036545|mint:P20674|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000178741(gene)|ensembl:ENST00000322347(transcript)|ensembl:ENST00000564811(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity) - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:dWvZKYawyJQwN29Mhkm44DXXqhg9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:P09669 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-715040|uniprotkb:B2R4D7|ensembl:ENSP00000297564|ensembl:ENSP00000428150|ensembl:ENSP00000428702|ensembl:ENSP00000428895|ensembl:ENSP00000428965|ensembl:ENSP00000429410|ensembl:ENSP00000429707|ensembl:ENSP00000429714|ensembl:ENSP00000429755|ensembl:ENSP00000429991 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox6c_human(display_long)|uniprotkb:COX6C(gene name)|psi-mi:COX6C(display_short)|uniprotkb:Cytochrome c oxidase polypeptide VIc(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_004365.1|refseq:XP_016868509.1|ensembl:ENSG00000164919(gene)|ensembl:ENST00000297564(transcript)|ensembl:ENST00000517682(transcript)|ensembl:ENST00000518171(transcript)|ensembl:ENST00000520271(transcript)|ensembl:ENST00000520468(transcript)|ensembl:ENST00000520517(transcript)|ensembl:ENST00000522934(transcript)|ensembl:ENST00000522940(transcript)|ensembl:ENST00000523016(transcript)|ensembl:ENST00000524245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004204(Cytochrome c oxidase subunit VIc)|interpro:IPR034884|interpro:IPR037169|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0006091"(generation of precursor metabolites and energy) - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:Zha4dqasvkWw3ACebJNflgxCVKo9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q7KZN9 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-3248549|ensembl:ENSP00000016171|uniprotkb:Q7Z3Q3|uniprotkb:O75878|uniprotkb:Q5TD00|uniprotkb:O60556|uniprotkb:A8K6I9|uniprotkb:Q5TD01|uniprotkb:Q9NTN0 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox15_human(display_long)|uniprotkb:COX15(gene name)|psi-mi:COX15(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 ensembl:ENSG00000014919(gene)|ensembl:ENST00000016171(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-HSA-189451|refseq:NP_004367.2|refseq:NP_510870.1|refseq:NP_001307903.1|refseq:NP_001307904.1|refseq:NP_001307905.1 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:wdz9gN+Wa6J/2OWm1flGDTmR7vM9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q15526 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-3915286|uniprotkb:Q5T8T3|uniprotkb:Q5T8T4|ensembl:ENSP00000361042|ensembl:ENSP00000487158 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:surf1_human(display_long)|uniprotkb:SURF1(gene name)|psi-mi:SURF1(display_short)|uniprotkb:SURF-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_003163.1|refseq:NP_001267716.1|ensembl:ENSG00000148290(gene)|ensembl:ENSG00000280627(gene)|ensembl:ENST00000371974(transcript)|ensembl:ENST00000626663(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR002994(Surfeit locus 1)|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:HGpXJhbeMdDuz7amqIgWqxlHicA9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:P00414 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-3932264|uniprotkb:Q14Y83|ensembl:ENSP00000354982 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox3_human(display_long)|uniprotkb:MT-CO3(gene name)|psi-mi:MT-CO3(display_short)|uniprotkb:COIII(gene name synonym)|uniprotkb:COXIII(gene name synonym)|uniprotkb:MTCO3(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide III(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 ensembl:ENSG00000198938(gene)|ensembl:ENST00000362079(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015453"(oxidoreduction-driven active transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045277"(respiratory chain complex IV)|interpro:IPR000298(Cytochrome c oxidase, subunit III)|interpro:IPR013833(Cytochrome c oxidase, subunit III, 4-helical bundle)|interpro:IPR024791|interpro:IPR033945|interpro:IPR035973|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|refseq:YP_003024032.1 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:ZsGHu+XXEfFZZecGf4EIhwQejAA9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q9BVV7 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:P00395 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q9P0S2 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6570716|uniprotkb:A6NDT5|uniprotkb:A8K3X8|ensembl:ENSP00000374562|uniprotkb:B8XYC5 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox16_human(display_long)|uniprotkb:COX16(gene name)|psi-mi:COX16(display_short)|uniprotkb:C14orf112(gene name synonym)|uniprotkb:HSPC203(orf name)|uniprotkb:PTD019(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_057552.1|ensembl:ENSG00000133983(gene)|ensembl:ENST00000389912(transcript)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR020164|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|refseq:NP_001191019.1 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:hBsiyBY4f/24iR1+/jo+10SiEQ09606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q7Z7K0 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6570685|uniprotkb:Q68DJ7|ensembl:ENSP00000418348 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:coxm1_human(display_long)|uniprotkb:CMC1(gene name)|psi-mi:CMC1(display_short)|uniprotkb:C3orf68(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_872329.1|ensembl:ENSG00000187118(gene)|ensembl:ENST00000466830(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0046872"(metal ion binding)|interpro:IPR013892(Protein of unknown function UPF0287) - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:XLpcUQKNCUyL+bnDHXL5ibCYqLg9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q96I36 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6570698|ensembl:ENSP00000326052|ensembl:ENSP00000446524|ensembl:ENSP00000447776|ensembl:ENSP00000450331|uniprotkb:B2R5G6 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox14_human(display_long)|uniprotkb:COX14(gene name)|psi-mi:COX14(display_short)|uniprotkb:C12orf62(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 ensembl:ENSG00000178449(gene)|ensembl:ENST00000317943(transcript)|ensembl:ENST00000548985(transcript)|ensembl:ENST00000550487(transcript)|ensembl:ENST00000550654(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR029208|reactome:R-HSA-5628897|reactome:R-HSA-611105|refseq:NP_001244062.1|refseq:NP_001244063.1|refseq:NP_116290.1|reactome:R-HSA-9707564 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:Vr9NrwDWz608Cjy6WwQjZup1bKQ9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q9Y375 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-741874|uniprotkb:Q9BVZ5|ensembl:ENSP00000260361|ensembl:ENSP00000453944 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cia30_human(display_long)|uniprotkb:NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1(gene name synonym)|uniprotkb:NDUFAF1(gene name)|psi-mi:NDUFAF1(display_short)|uniprotkb:CIA30(gene name synonym)|uniprotkb:CGI-65(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_057097.2|ensembl:ENSG00000137806(gene)|ensembl:ENST00000260361(transcript)|ensembl:ENST00000560978(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0010257"(NADH dehydrogenase complex assembly)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013857("NADH:ubiquinone oxidoreductase complex I intermediate-associated protein 30")|interpro:IPR039131|mint:Q9Y375|reactome:R-HSA-6799198|refseq:XP_011519960.1|refseq:XP_006720618.1 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:cZmtaAs6upui/PVTTBGQBEOcWvk9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q00325 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-358549|uniprotkb:Q96A03|intact:EBI-28967087|ensembl:ENSP00000228318|ensembl:ENSP00000447310|uniprotkb:Q7Z7N7|uniprotkb:B3KS34 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:mpcp_human(display_long)|uniprotkb:SLC25A3(gene name)|psi-mi:SLC25A3(display_short)|uniprotkb:PHC(gene name synonym)|uniprotkb:OK/SW-cl.48(orf name)|uniprotkb:Phosphate transport protein(gene name synonym)|uniprotkb:Solute carrier family 25 member 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 ensembl:ENST00000188376|ensembl:ENSP00000188376|ensembl:ENSP00000228318|ensembl:ENST00000401722|ensembl:ENSP00000383898|ensembl:ENST00000549338|ensembl:ENSP00000447740|ensembl:ENSP00000447310|ensembl:ENST00000552981|ensembl:ENSP00000448708|refseq:NP_002626.1|refseq:NP_005879.1|refseq:NP_998776.1|ensembl:ENSG00000075415(gene)|ensembl:ENST00000228318(transcript)|ensembl:ENST00000551917(transcript)|go:"GO:0005315"(inorganic phosphate transmembrane transporter activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015317"("phosphate:proton symporter activity")|go:"GO:0016020"(membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990547"(mitochondrial phosphate ion transmembrane transport)|interpro:IPR018108|interpro:IPR023395|interpro:IPR044677|mint:Q00325 - - crc64:78714C85931B22D5 figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:f8THTDwNPyGowC9gCT9ZsizQ6qs9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:B4DRS6 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6570810 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:b4drs6_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 interpro:IPR004686(Tricarboxylate/iron carrier)|go:"GO:0006865"(amino acid transport)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane) - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:X6oQtLPX2y0bU2qNMm7BCiRIkHg9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:O95298 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-1246172|uniprotkb:Q9UBJ9|uniprotkb:Q6FIH8|uniprotkb:Q549M5|uniprotkb:E9PNU8|uniprotkb:E9PRB2|ensembl:ENSP00000281031 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:nduc2_human(display_long)|uniprotkb:NDUFC2(gene name)|psi-mi:NDUFC2(display_short)|uniprotkb:HLC1(orf name)|uniprotkb:NADH-ubiquinone oxidoreductase subunit B14.5b(gene name synonym)|uniprotkb:Complex I-B14.5b(gene name synonym)|uniprotkb:Human lung cancer oncogene 1 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_004540.1|refseq:NP_001190983.1|refseq:NP_001190984.1|ensembl:ENSG00000151366(gene)|ensembl:ENST00000281031(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005886"(plasma membrane)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0035577"(azurophil granule membrane)|interpro:IPR009423(NADH-ubiquinone oxidoreductase subunit b14.5b)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6798695|reactome:R-HSA-6799198 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:IILkKsJHyRjCMZJ6z//WjdRXQUQ9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:A0PJW6 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6570796|uniprotkb:Q504S0|uniprotkb:Q86YD4|uniprotkb:Q8WUC5|uniprotkb:Q96HG0|ensembl:ENSP00000303987 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:tm223_human(display_long)|uniprotkb:TMEM223(gene name)|psi-mi:TMEM223(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_001073970.1|ensembl:ENSG00000168569(gene)|ensembl:ENST00000307366(transcript)|go:"GO:0007399"(nervous system development)|go:"GO:0016021"(integral component of membrane)|interpro:IPR026100 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:lAHosIG6Gfn6JCOdAHXz/TPYyLE9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q6P4A7 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-1049439|uniprotkb:Q6WSU4|uniprotkb:Q86TD9|ensembl:ENSP00000347924 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:sfxn4_human(display_long)|uniprotkb:Breast cancer resistance marker 1(gene name synonym)|uniprotkb:SFXN4(gene name)|psi-mi:SFXN4(display_short)|uniprotkb:BCRM1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_998814.1|refseq:XP_011537584.1|refseq:XP_005269583.1|refseq:XP_005269584.1|ensembl:ENSG00000183605(gene)|ensembl:ENST00000355697(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006865"(amino acid transport)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:1990542"(mitochondrial transmembrane transport)|interpro:IPR004686(Tricarboxylate/iron carrier)|interpro:IPR028825 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:D/Ae1Kd5aIiliqNVmS7aFaIpwsk9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q9H9B4 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-355861|uniprotkb:Q9HA53|uniprotkb:B3KPW3|uniprotkb:D3DQN2|ensembl:ENSP00000316905 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:sfxn1_human(display_long)|uniprotkb:SFXN1(gene name)|psi-mi:SFXN1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_073591.2|refseq:NP_001309906.1|ensembl:ENSG00000164466(gene)|ensembl:ENST00000321442(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0015194"(L-serine transmembrane transporter activity)|go:"GO:0015825"(L-serine transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0022889"(serine transmembrane transporter activity)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0042942"(D-serine transport)|go:"GO:0042945"(D-serine transmembrane transporter activity)|go:"GO:0140300"(serine import into mitochondrion)|go:"GO:1990542"(mitochondrial transmembrane transport)|interpro:IPR004686(Tricarboxylate/iron carrier)|mint:Q9H9B4 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:n/i6d8Rt+xMOvu3BrZfc0VP0+Wk9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q96E52 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6570817|uniprotkb:D3DQ54|uniprotkb:Q5T3G6|uniprotkb:Q5T3G7|uniprotkb:Q5T3G8|uniprotkb:Q5T3G9|uniprotkb:Q5T3H0|uniprotkb:Q8NBB3|ensembl:ENSP00000360270 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:oma1_human(display_long)|uniprotkb:OMA1(gene name)|psi-mi:OMA1(display_short)|uniprotkb:MPRP1(gene name synonym)|uniprotkb:Metalloprotease-related protein 1(gene name synonym)|uniprotkb:Overlapping with the m-AAA protease 1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_660286.1|ensembl:ENSG00000162600(gene)|ensembl:ENST00000371226(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031638"(zymogen activation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903850"(regulation of cristae formation)|interpro:IPR001915(Peptidase M48, Ste24p)|reactome:R-HSA-169911 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:jwXfSvQN3WtLQG4R0yb3+kZaIYw9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q9BQ95 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-712452|uniprotkb:Q9NYI1|uniprotkb:Q96HQ7|ensembl:ENSP00000270517|uniprotkb:E9PAN9|uniprotkb:K7EMM0 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:ecsit_human(display_long)|uniprotkb:Protein SITPEC(gene name synonym)|uniprotkb:ECSIT(gene name)|psi-mi:ECSIT(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 ensembl:ENSG00000130159(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0045087"(innate immune response)|go:"GO:0051341"(regulation of oxidoreductase activity)|go:"GO:0061635"(regulation of protein complex stability)|interpro:IPR010418(ECSIT)|interpro:IPR029342|reactome:R-HSA-166058|reactome:R-HSA-6799198|reactome:R-HSA-975138|reactome:R-HSA-975871|ensembl:ENST00000270517(transcript)|refseq:NP_001230133.1|refseq:NP_001135937.1|refseq:NP_001135936.1|refseq:NP_057665.2 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:9gpZoQnhuP1vkFOPhXHkF1kHB8Q9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q8N5G0 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6570855|ensembl:ENSP00000427407|uniprotkb:C9JYT8|uniprotkb:Q9BRT5 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:sim20_human(display_long)|uniprotkb:SMIM20(gene name)|psi-mi:SMIM20(display_short)|uniprotkb:C4orf52(gene name synonym)|uniprotkb:MITRAC7(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 7 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 ensembl:ENSG00000250317(gene)|ensembl:ENST00000506197(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR027917|mint:Q8N5G0|refseq:NP_001138904.1 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:yqRjpvlmOpU7RfsXACpQ7ytSFZE9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q8NBN7 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-3922765|uniprotkb:Q96G88|uniprotkb:Q6UX79|ensembl:ENSP00000391121|ensembl:ENSP00000477512 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:rdh13_human(display_long)|uniprotkb:RDH13(gene name)|psi-mi:RDH13(display_short)|uniprotkb:SDR7C3(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 7C member 3(gene name synonym)|uniprotkb:PSEC0082(orf name)|uniprotkb:UNQ736/PRO1430(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:XP_011524709.1|refseq:NP_001139443.1|refseq:NP_612421.1|ensembl:ENSG00000160439(gene)|ensembl:ENST00000615256(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0009644"(response to high light intensity)|go:"GO:0010842"(retina layer formation)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042574"(retinal metabolic process)|go:"GO:0052650"(NADP-retinol dehydrogenase activity)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:Q8NBN7|reactome:R-HSA-5365859|ensembl:ENSG00000276684(gene)|ensembl:ENST00000415061(transcript)|refseq:XP_005258530.1 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:UHfrKddjwiPXJ6xohB99Ua0jGZo9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q53S58 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6570866|ensembl:ENSP00000272521|ensembl:ENSP00000385966|ensembl:ENSP00000402661|uniprotkb:Q9BT20 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:tm177_human(display_long)|uniprotkb:TMEM177(gene name)|psi-mi:TMEM177(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 ensembl:ENSG00000144120(gene)|ensembl:ENST00000272521(transcript)|ensembl:ENST00000401466(transcript)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|interpro:IPR026620|ensembl:ENST00000424086(transcript)|refseq:NP_001098668.1|refseq:NP_001098669.1|refseq:NP_085054.2 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:m9+wtkkUn99k3SsITaPwDa0cN149606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q9NPL8 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6268651|ensembl:ENSP00000418803|uniprotkb:D3DN81|uniprotkb:Q6IAJ7|uniprotkb:Q6UWU6|uniprotkb:Q9NPR3|uniprotkb:Q9NPS5|uniprotkb:Q9P0Y6 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:tidc1_human(display_long)|uniprotkb:Translocase of inner mitochondrial membrane domain-containing protein 1(gene name synonym)|uniprotkb:UNQ247/PRO284(orf name)|uniprotkb:TIMMDC1(gene name)|psi-mi:TIMMDC1(display_short)|uniprotkb:C3orf1(gene name synonym)|uniprotkb:Protein M5-14(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 ensembl:ENSG00000113845(gene)|ensembl:ENST00000494664(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|reactome:R-HSA-6799198|refseq:NP_057673.2 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:unRvwLcwr8HPurvP0QImnk9d5ko9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q305V2 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6570880 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:q305v2_human(display_long)|uniprotkb:ND2(gene name)|psi-mi:ND2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0070469"(respirasome)|interpro:IPR010933(NADH dehydrogenase subunit 2, C-terminal)|interpro:IPR001750("NADH/Ubiquinone/plastoquinone (complex I)")|interpro:IPR003917(NADH-ubiquinone oxidoreductase, chain 2) - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:Ir76+Ip3ptK1SXM8hlnzCmIQBkw9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q9Y6N1 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-2963275|uniprotkb:I3L220|ensembl:ENSP00000299335|ensembl:ENSP00000459901|uniprotkb:Q6FHB7|uniprotkb:Q9BRX0|uniprotkb:Q9UME8|uniprotkb:D3DTY5 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox11_human(display_long)|uniprotkb:COX11(gene name)|psi-mi:COX11(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 ensembl:ENSG00000166260(gene)|ensembl:ENST00000299335(transcript)|ensembl:ENST00000576370(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0009055"(electron transfer activity)|go:"GO:0031304"(intrinsic component of mitochondrial inner membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0055065"(metal ion homeostasis)|interpro:IPR007533(Cytochrome c oxidase assembly protein CtaG/Cox11)|interpro:IPR023471|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|refseq:NP_004366.1|refseq:XP_011522644.1|refseq:XP_016879681.1|refseq:XP_016879682.1|refseq:XP_016879683.1|refseq:XP_016879684.1|refseq:XP_016879685.1 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:inklcaALt6Jb0Cs/4ckzcG6YrHA9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q02978 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-359174|uniprotkb:O75537|uniprotkb:Q969P7|ensembl:ENSP00000225665|uniprotkb:F5GY65 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:m2om_human(display_long)|uniprotkb:SLC25A11(gene name)|psi-mi:SLC25A11(display_short)|uniprotkb:SLC20A4(gene name synonym)|uniprotkb:Solute carrier family 25 member 11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_003553.2|go:"GO:0071423"(malate transmembrane transport)|interpro:IPR018108|interpro:IPR023395|mint:Q02978|reactome:R-HSA-70263|ensembl:ENSG00000108528(gene)|ensembl:ENST00000225665(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008272"(sulfate transport)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015117"(thiosulfate transmembrane transporter activity)|go:"GO:0015131"(oxaloacetate transmembrane transporter activity)|go:"GO:0015140"(malate transmembrane transporter activity)|go:"GO:0015141"(succinate transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0015367"("oxoglutarate:malate antiporter activity")|go:"GO:0015709"(thiosulfate transport)|go:"GO:0015729"(oxaloacetate transport)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0071422"(succinate transmembrane transport) - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:TPeF6k/rQq+WJ9omeDK4V6NY4/o9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:O75746 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-1047585|uniprotkb:Q96AM8|intact:EBI-2802067|uniprotkb:B3KR64|ensembl:ENSP00000388658 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cmc1_human(display_long)|uniprotkb:SLC25A12(gene name)|psi-mi:SLC25A12(display_short)|uniprotkb:ARALAR1(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_003696.2|ensembl:ENSG00000115840(gene)|ensembl:ENST00000422440(transcript)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0051592"(response to calcium ion)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:O75746|rcsb pdb:4P5X|rcsb pdb:4P60|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:NMohxjKtV1fhusocdkdQYZ/ng3I9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:P25685 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-357034|ensembl:ENSP00000254322|uniprotkb:B4DX52 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:dnjb1_human(display_long)|uniprotkb:DNAJB1(gene name)|psi-mi:DNAJB1(display_short)|uniprotkb:DNAJ1(gene name synonym)|uniprotkb:HDJ1(gene name synonym)|uniprotkb:HSPF1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1(gene name synonym)|uniprotkb:Human DnaJ protein 1(gene name synonym)|uniprotkb:DnaJ protein homolog 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 dip:DIP-41180N|ensembl:ENSG00000132002(gene)|ensembl:ENST00000254322(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|refseq:NP_006136.1|refseq:XP_006722796.1|refseq:NP_001287843.1|refseq:NP_001300893.1|refseq:XP_011526258.1|refseq:XP_006722797.1|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061827"(sperm head)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR018253|interpro:IPR036869|mint:P25685|rcsb pdb:1HDJ|rcsb pdb:2QLD|rcsb pdb:3AGX|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:4WB7|rcsb pdb:6BYR|rcsb pdb:6WJF|rcsb pdb:6WJG|rcsb pdb:6Z5N|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-5687128|interpro:IPR008971(HSP40/DnaJ peptide-binding) - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:8NJHM7hHFc+zqulNiUM9UMxT/ws9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q8N490 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-746368|uniprotkb:Q96A48|uniprotkb:Q9BU26|uniprotkb:Q9NSX4|uniprotkb:Q9ULN6|uniprotkb:Q9Y4T1|uniprotkb:A8K1F2|ensembl:ENSP00000273077 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:pnkd_human(display_long)|uniprotkb:Paroxysmal nonkinesiogenic dyskinesia protein(gene name synonym)|uniprotkb:Myofibrillogenesis regulator 1(gene name synonym)|uniprotkb:Trans-activated by hepatitis C virus core protein 2(gene name synonym)|uniprotkb:PNKD(gene name)|psi-mi:PNKD(display_short)|uniprotkb:KIAA1184(gene name synonym)|uniprotkb:MR1(gene name synonym)|uniprotkb:TAHCCP2(gene name synonym)|uniprotkb:FKSG19(orf name)|uniprotkb:UNQ2491/PRO5778(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_001070867.1|refseq:NP_056303.3|refseq:NP_072094.1|ensembl:ENST00000273077(transcript)|go:"GO:0004416"(hydroxyacylglutathione hydrolase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0016020"(membrane)|go:"GO:0019243"(methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0050884"(neuromuscular process controlling posture)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR017782(Hydroxyacylglutathione hydrolase)|interpro:IPR032282|interpro:IPR035680|interpro:IPR036866|ensembl:ENSG00000127838(gene) - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:LKItPq0mJBGgqEeDl3LoJAeTAl09606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q56VL3 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6152758|uniprotkb:Q8N544|uniprotkb:B4DPE7|ensembl:ENSP00000423014 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:ocad2_human(display_long)|uniprotkb:Ovarian carcinoma immunoreactive antigen-like protein(gene name synonym)|uniprotkb:OCIAD2(gene name)|psi-mi:OCIAD2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_001014446.1|refseq:NP_689611.1|refseq:NP_001273702.1|ensembl:ENSG00000145247(gene)|ensembl:ENST00000508632(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006897"(endocytosis)|go:"GO:0009617"(response to bacterium)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009764(Ovarian carcinoma immunoreactive antigen)|interpro:IPR040187 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:z4I/nxTOVnbJ/RZhY11VYbBas0g9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q9BUB7 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-726363|uniprotkb:Q9NWY5|uniprotkb:E9PDY9|ensembl:ENSP00000312599 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:tmm70_human(display_long)|uniprotkb:TMEM70(gene name)|psi-mi:TMEM70(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_001035703.1|refseq:NP_060336.3|ensembl:ENSG00000175606(gene)|ensembl:ENST00000312184(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033615"(mitochondrial proton-transporting ATP synthase complex assembly)|interpro:IPR009724(Protein of unknown function DUF1301)|mint:Q9BUB7|go:"GO:0005743"(mitochondrial inner membrane) - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:6LHWSQP2W1CRBgylWi8Ncc3X/3E9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:P13073 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570697|imex:IM-18725-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Figure 3B and Table S1|author-confidence:MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 intact-crc:A8DADA030E8E9424|rigid:eXh0iN0bCGj65gFFnHXJxwCPZtA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:Q96I36 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6570698|ensembl:ENSP00000326052|ensembl:ENSP00000446524|ensembl:ENSP00000447776|ensembl:ENSP00000450331|uniprotkb:B2R5G6 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox14_human(display_long)|uniprotkb:COX14(gene name)|psi-mi:COX14(display_short)|uniprotkb:C12orf62(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655923|imex:IM-18725-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 ensembl:ENSG00000178449(gene)|ensembl:ENST00000317943(transcript)|ensembl:ENST00000548985(transcript)|ensembl:ENST00000550487(transcript)|ensembl:ENST00000550654(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR029208|reactome:R-HSA-5628897|reactome:R-HSA-611105|refseq:NP_001244062.1|refseq:NP_001244063.1|refseq:NP_116290.1|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 3E|comment:Proteins first isolated by anti-Flag coimmunoprecipitation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:Vr9NrwDWz608Cjy6WwQjZup1bKQ9606 intact-crc:D54AEC853B882994|rigid:o978vbNmMPHtDohRwM71zJaZUts false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:P00395 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655923|imex:IM-18725-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 3E|comment:Proteins first isolated by anti-Flag coimmunoprecipitation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 intact-crc:D54AEC853B882994|rigid:o978vbNmMPHtDohRwM71zJaZUts false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:P00395 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570653|imex:IM-18725-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Supp Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 intact-crc:8528A95BA7955F7F|rigid:JNxBd9dqvmGCDbMHhYYMKQZY6E4 false flag tag:c-c|35s radiolabel:?-? 35s radiolabel:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:P00395 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655986|imex:IM-18725-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 4E|comment:Proteins first isolated by anti-Flag coimmunoprecipitation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 intact-crc:0DDD787718DCCE51|rigid:6JDCgJkVKavoF7qGFuEhsZvuf58 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:Q7Z7K0 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-6570685|uniprotkb:Q68DJ7|ensembl:ENSP00000418348 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:coxm1_human(display_long)|uniprotkb:CMC1(gene name)|psi-mi:CMC1(display_short)|uniprotkb:C3orf68(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6655986|imex:IM-18725-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_872329.1|ensembl:ENSG00000187118(gene)|ensembl:ENST00000466830(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0046872"(metal ion binding)|interpro:IPR013892(Protein of unknown function UPF0287) go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 4E|comment:Proteins first isolated by anti-Flag coimmunoprecipitation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:XLpcUQKNCUyL+bnDHXL5ibCYqLg9606 intact-crc:0DDD787718DCCE51|rigid:6JDCgJkVKavoF7qGFuEhsZvuf58 false - flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P00395 uniprotkb:Q9Y2R0 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570607|imex:IM-18725-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 1H|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 intact-crc:100EBC897E54EBC1|rigid:JNxBd9dqvmGCDbMHhYYMKQZY6E4 false - flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P00395 uniprotkb:P13073 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570593|imex:IM-18725-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Fig. 1H|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 intact-crc:D11E7C09521E2374|rigid:mD4V/3R4i+asRXWCJfQ8xAUSGiQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P00395 uniprotkb:P13073 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570615|imex:IM-18725-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Fig. 1H|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 intact-crc:B8F5AFBFF83DF09B|rigid:zOpjCk8v9k8pyNWJXEETx95/UWw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P00395 uniprotkb:Q16795 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 intact:EBI-1045087|uniprotkb:Q14076|uniprotkb:Q2NKX0|ensembl:ENSP00000266544 psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:ndua9_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 39 kDa subunit(gene name synonym)|uniprotkb:Complex I-39kD(gene name synonym)|uniprotkb:NDUFA9(gene name)|psi-mi:NDUFA9(display_short)|uniprotkb:NDUFS2L(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570615|imex:IM-18725-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_004993.1|ensembl:ENSG00000139180(gene)|ensembl:ENST00000266544(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009749"(response to glucose)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1901006"(ubiquinone-6 biosynthetic process)|interpro:IPR001509(NAD-dependent epimerase/dehydratase)|interpro:IPR036291|mint:Q16795|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|dip:DIP-38526N - - - figure legend:Fig. 1H|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 rogid:eM2zUsbdjMEILIcUedVOyEMwAzU9606 intact-crc:B8F5AFBFF83DF09B|rigid:zOpjCk8v9k8pyNWJXEETx95/UWw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9H845 uniprotkb:P24539 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656070|imex:IM-18725-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 intact-crc:5A79ABF3E1A95417|rigid:yDlx0EdsUQSmAresOupHPpjsnMA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H845 uniprotkb:O75947 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 intact:EBI-724024|ensembl:ENSP00000301587|uniprotkb:Q9H3J4|uniprotkb:B2R5L6 psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:atp5h_human(display_long)|uniprotkb:ATP5PD(gene name)|psi-mi:ATP5PD(display_short)|uniprotkb:ATP synthase peripheral stalk subunit d(gene name synonym)|uniprotkb:ATP5H(gene name synonym)|uniprotkb:My032(orf name) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656070|imex:IM-18725-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N refseq:NP_001003785.1|refseq:NP_006347.1|ensembl:ENSG00000167863(gene)|ensembl:ENST00000301587(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|interpro:IPR008689(ATPase, F0 complex, subunit D, mitochondrial)|interpro:IPR036228|mint:O75947|reactome:R-HSA-163210|reactome:R-HSA-8949613 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rogid:GFk/w7iWIjum9BpZs8ZlPrM5kBs9606 intact-crc:5A79ABF3E1A95417|rigid:yDlx0EdsUQSmAresOupHPpjsnMA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H845 uniprotkb:O75964 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 intact:EBI-1044001|uniprotkb:Q96BV6|uniprotkb:Q9UBZ7|ensembl:ENSP00000300688|uniprotkb:A8K0K3 psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:atp5l_human(display_long)|uniprotkb:ATP5MG(gene name)|psi-mi:ATP5MG(display_short)|uniprotkb:ATP synthase membrane subunit g(gene name synonym)|uniprotkb:ATP5L(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656070|imex:IM-18725-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N refseq:NP_006467.4|ensembl:ENSG00000167283(gene)|ensembl:ENST00000300688(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|interpro:IPR006808(ATPase, F0 complex, subunit G, mitochondrial)|interpro:IPR016702(Mitochondrial ATP synthase subunit g, animal)|mint:O75964|reactome:R-HSA-163210|reactome:R-HSA-8949613 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rogid:mn5/fFqk4xCCHb/MEuLAi5/lqmI9606 intact-crc:5A79ABF3E1A95417|rigid:yDlx0EdsUQSmAresOupHPpjsnMA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H845 uniprotkb:P00846 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 intact:EBI-1389380|uniprotkb:Q34772|uniprotkb:Q5S8W5|uniprotkb:Q5S9E7|uniprotkb:Q5S9I6|uniprotkb:Q5SA31|uniprotkb:Q6RPB7|uniprotkb:Q6VHC0|uniprotkb:Q6VHE0|uniprotkb:Q6WQF4|uniprotkb:Q7YCC1|uniprotkb:Q7YCF8|uniprotkb:Q7YCG1|uniprotkb:Q85KU8|uniprotkb:Q85KX1|uniprotkb:Q85L05|uniprotkb:Q8HNQ4|uniprotkb:Q8HNQ8|uniprotkb:Q8WCX6|uniprotkb:Q9B2U5|uniprotkb:Q9B2Z2|ensembl:ENSP00000354632 psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:atp6_human(display_long)|uniprotkb:MT-ATP6(gene name)|psi-mi:MT-ATP6(display_short)|uniprotkb:ATP6(gene name synonym)|uniprotkb:ATPASE6(gene name synonym)|uniprotkb:MTATP6(gene name synonym)|uniprotkb:F-ATPase protein 6(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656070|imex:IM-18725-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N refseq:YP_003024031.1|go:"GO:0045263"("proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0055093"(response to hyperoxia)|interpro:IPR000568(ATPase, F0 complex, subunit A)|interpro:IPR023011|interpro:IPR035908|mint:P00846|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENSG00000198899(gene)|ensembl:ENST00000361899(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0007568"(aging)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rogid:XGt0uP3ldTsWyNSOEiT5kDR5kOw9606 intact-crc:5A79ABF3E1A95417|rigid:yDlx0EdsUQSmAresOupHPpjsnMA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H845 uniprotkb:P25705 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 intact:EBI-351437|uniprotkb:Q53XX6|uniprotkb:Q8IXV2|uniprotkb:Q96FB4|uniprotkb:Q96HW2|uniprotkb:Q96IR6|uniprotkb:Q9BTV8|intact:EBI-11032691|uniprotkb:A8K092|uniprotkb:B4DY56|uniprotkb:K7ENP3|ensembl:ENSP00000282050|ensembl:ENSP00000381736 psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:atpa_human(display_long)|uniprotkb:ATP5F1A(gene name)|psi-mi:ATP5F1A(display_short)|uniprotkb:ATP synthase F1 subunit alpha(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5A1(gene name synonym)|uniprotkb:ATP5AL2(gene name synonym)|uniprotkb:ATPM(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656070|imex:IM-18725-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N refseq:NP_001244263.1|refseq:NP_001001937.1|refseq:NP_004037.1|refseq:NP_001001935.1|refseq:NP_001244264.1|dip:DIP-32871N|ensembl:ENSG00000152234(gene)|ensembl:ENST00000282050(transcript)|ensembl:ENST00000398752(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR000793(ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005294(ATPase, F1 complex, alpha subunit)|interpro:IPR020003|interpro:IPR023366|interpro:IPR027417|interpro:IPR033732|interpro:IPR036121|interpro:IPR038376|mint:P25705|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-8949613 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rogid:Sy/Ii5ea+ilCKGBnIEMn133Vogc9606 intact-crc:5A79ABF3E1A95417|rigid:yDlx0EdsUQSmAresOupHPpjsnMA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H845 uniprotkb:P06576 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 intact:EBI-356231|ensembl:ENSP00000262030|uniprotkb:Q14283|uniprotkb:A8K4X0|intact:EBI-2322803 psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:atpb_human(display_long)|uniprotkb:ATP5F1B(gene name)|psi-mi:ATP5F1B(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:ATP5B(gene name synonym)|uniprotkb:ATPMB(gene name synonym)|uniprotkb:ATPSB(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656070|imex:IM-18725-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N ensembl:ENSG00000110955(gene)|ensembl:ENST00000262030(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005722(ATPase, F1 complex, beta subunit)|interpro:IPR020003|interpro:IPR024034|interpro:IPR027417|interpro:IPR036121|mint:P06576|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-2151201|reactome:R-HSA-8949613|go:"GO:0070062"(extracellular exosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|refseq:NP_001677.2 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rogid:oLPUvG1tQkkzxzeAG6R0ZkZF+eg9606 intact-crc:5A79ABF3E1A95417|rigid:yDlx0EdsUQSmAresOupHPpjsnMA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H845 uniprotkb:P30049 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 intact:EBI-1049505|uniprotkb:Q6FG90|uniprotkb:D6W5Y3|ensembl:ENSP00000215375|ensembl:ENSP00000378995|ensembl:ENSP00000464863 psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:atpd_human(display_long)|uniprotkb:ATP5F1D(gene name)|psi-mi:ATP5F1D(display_short)|uniprotkb:ATP synthase F1 subunit delta(gene name synonym)|uniprotkb:ATP5D(gene name synonym)|uniprotkb:F-ATPase delta subunit(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656070|imex:IM-18725-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N refseq:NP_001001975.1|refseq:NP_001678.1|ensembl:ENSG00000099624(gene)|ensembl:ENST00000215375(transcript)|ensembl:ENST00000395633(transcript)|ensembl:ENST00000591660(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0033615"(mitochondrial proton-transporting ATP synthase complex assembly)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046688"(response to copper ion)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR001469(ATPase, F1 complex, delta/epsilon subunit)|interpro:IPR020546|interpro:IPR036771|interpro:IPR036794|mint:P30049|reactome:R-HSA-163210|reactome:R-HSA-8949613 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rogid:OA8if7wpjwV6hkkaLqPyz6YDljc9606 intact-crc:5A79ABF3E1A95417|rigid:yDlx0EdsUQSmAresOupHPpjsnMA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H845 uniprotkb:P36542 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 intact:EBI-711768|uniprotkb:Q5VYP3|uniprotkb:Q96AS8|uniprotkb:A8KA31|intact:EBI-3962282|uniprotkb:Q6I9V2|ensembl:ENSP00000349142 psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:atpg_human(display_long)|uniprotkb:ATP5F1C(gene name)|psi-mi:ATP5F1C(display_short)|uniprotkb:ATP synthase F1 subunit gamma(gene name synonym)|uniprotkb:ATP5C(gene name synonym)|uniprotkb:ATP5C1(gene name synonym)|uniprotkb:ATP5CL1(gene name synonym)|uniprotkb:F-ATPase gamma subunit(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656070|imex:IM-18725-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N refseq:NP_001001973.1|refseq:NP_005165.1|ensembl:ENSG00000165629(gene)|ensembl:ENST00000356708(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR000131(ATPase, F1 complex, gamma subunit)|interpro:IPR023632|interpro:IPR035968|mint:P36542|reactome:R-HSA-163210|reactome:R-HSA-8949613 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rogid:k3Nfa1hSoREyiKzFbmaZqxLhiLY9606 intact-crc:5A79ABF3E1A95417|rigid:yDlx0EdsUQSmAresOupHPpjsnMA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H845 uniprotkb:P48047 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 intact:EBI-355815|uniprotkb:Q5U042|uniprotkb:Q6IBI2|uniprotkb:B2R4E2|ensembl:ENSP00000290299 psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:atpo_human(display_long)|uniprotkb:ATP5PO(gene name)|psi-mi:ATP5PO(display_short)|uniprotkb:ATP synthase peripheral stalk subunit OSCP(gene name synonym)|uniprotkb:ATP5O(gene name synonym)|uniprotkb:ATPO(gene name synonym)|uniprotkb:Oligomycin sensitivity conferral protein(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656070|imex:IM-18725-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N refseq:NP_001688.1|ensembl:ENSG00000241837(gene)|ensembl:ENST00000290299(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000711(ATPase, F1 complex, OSCP/delta subunit)|interpro:IPR020781|interpro:IPR026015|mint:P48047|reactome:R-HSA-163210|reactome:R-HSA-8949613 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rogid:4lQel+z57OEHJXVWW8ijNyp2h2U9606 intact-crc:5A79ABF3E1A95417|rigid:yDlx0EdsUQSmAresOupHPpjsnMA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H845 uniprotkb:Q9BQ95 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 intact:EBI-712452|uniprotkb:Q9NYI1|uniprotkb:Q96HQ7|ensembl:ENSP00000270517|uniprotkb:E9PAN9|uniprotkb:K7EMM0 psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:ecsit_human(display_long)|uniprotkb:Protein SITPEC(gene name synonym)|uniprotkb:ECSIT(gene name)|psi-mi:ECSIT(display_short) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656070|imex:IM-18725-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N ensembl:ENSG00000130159(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0045087"(innate immune response)|go:"GO:0051341"(regulation of oxidoreductase activity)|go:"GO:0061635"(regulation of protein complex stability)|interpro:IPR010418(ECSIT)|interpro:IPR029342|reactome:R-HSA-166058|reactome:R-HSA-6799198|reactome:R-HSA-975138|reactome:R-HSA-975871|ensembl:ENST00000270517(transcript)|refseq:NP_001230133.1|refseq:NP_001135937.1|refseq:NP_001135936.1|refseq:NP_057665.2 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rogid:9gpZoQnhuP1vkFOPhXHkF1kHB8Q9606 intact-crc:5A79ABF3E1A95417|rigid:yDlx0EdsUQSmAresOupHPpjsnMA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H845 uniprotkb:Q96CU9 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 intact:EBI-372820|uniprotkb:Q71MG0|uniprotkb:Q9BU39|uniprotkb:Q9UKY9|uniprotkb:B3KN84|uniprotkb:B4DHU2|ensembl:ENSP00000263578 psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:fxrd1_human(display_long)|uniprotkb:FP634(orf name)|uniprotkb:FOXRED1(gene name)|psi-mi:FOXRED1(display_short) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656070|imex:IM-18725-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N refseq:NP_060017.1|refseq:XP_006718944.1|refseq:XP_016873492.1|refseq:XP_016873493.1|refseq:XP_016873494.1|ensembl:ENSG00000110074(gene)|ensembl:ENST00000263578(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR006076(FAD dependent oxidoreductase)|interpro:IPR036188 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rogid:cAeSafbcQmh6XLk/IrNfsD+KHtA9606 intact-crc:5A79ABF3E1A95417|rigid:yDlx0EdsUQSmAresOupHPpjsnMA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H845 uniprotkb:P21796 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 intact:EBI-354158|uniprotkb:Q5FVE7|uniprotkb:Q9UIQ5|uniprotkb:Q9UPL0|uniprotkb:B3KVK4|uniprotkb:D3DQ93|ensembl:ENSP00000265333|ensembl:ENSP00000378484|ensembl:ENSP00000378487 psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:vdac1_human(display_long)|uniprotkb:VDAC1(gene name)|psi-mi:VDAC1(display_short)|uniprotkb:VDAC(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym)|uniprotkb:Porin 31HL(gene name synonym)|uniprotkb:Porin 31HM(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656070|imex:IM-18725-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N refseq:NP_003365.1|refseq:XP_005272132.1|refseq:XP_016865310.1|refseq:XP_016865311.1|refseq:XP_016865312.1|dip:DIP-32862N|ensembl:ENSG00000213585(gene)|ensembl:ENST00000265333(transcript)|ensembl:ENST00000395044(transcript)|ensembl:ENST00000395047(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:P21796|rcsb pdb:2JK4|rcsb pdb:2K4T|rcsb pdb:5JDP|rcsb pdb:5XDN|rcsb pdb:5XDO|rcsb pdb:6G6U|rcsb pdb:6G73|rcsb pdb:6TIQ|rcsb pdb:6TIR|reactome:R-HSA-1268020|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-70268|reactome:R-HSA-8949215 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rogid:8Fqe6Ga3NmwwuICa4L45ga2i1nk9606 intact-crc:5A79ABF3E1A95417|rigid:yDlx0EdsUQSmAresOupHPpjsnMA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H845 uniprotkb:P45880 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6 psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656070|imex:IM-18725-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rogid:seQxCd19Z2HmpXcwb48osAuuafA9606 intact-crc:5A79ABF3E1A95417|rigid:yDlx0EdsUQSmAresOupHPpjsnMA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H845 uniprotkb:Q9Y277 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 intact:EBI-354196|uniprotkb:Q9UIS0|ensembl:ENSP00000022615 psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:vdac3_human(display_long)|uniprotkb:VDAC3(gene name)|psi-mi:VDAC3(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 3(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656070|imex:IM-18725-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N refseq:NP_001129166.1|refseq:NP_005653.3|ensembl:ENSG00000078668(gene)|ensembl:ENST00000022615(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015853"(adenine transport)|go:"GO:0016020"(membrane)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030271|mint:Q9Y277|reactome:R-HSA-5689880|reactome:R-HSA-8949215 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 rogid:En6g89Dp+C4s1ArGYJyVfUBVsO09606 intact-crc:5A79ABF3E1A95417|rigid:yDlx0EdsUQSmAresOupHPpjsnMA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05141 uniprotkb:P12236 intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671 intact:EBI-356254|ensembl:ENSP00000370808|uniprotkb:Q96C49 psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym) psi-mi:adt3_human(display_long)|uniprotkb:SLC25A6(gene name)|psi-mi:SLC25A6(display_short)|uniprotkb:ANT3(gene name synonym)|uniprotkb:CDABP0051(orf name)|uniprotkb:Adenine nucleotide translocator 3(gene name synonym)|uniprotkb:ADP,ATP carrier protein 3(gene name synonym)|uniprotkb:Solute carrier family 25 member 6(gene name synonym)|uniprotkb:ADP,ATP carrier protein, isoform T2(gene name synonym)|uniprotkb:AAC3(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656154|imex:IM-18725-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N ensembl:ENSG00000169100(gene)|ensembl:ENST00000381401(transcript)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P12236|reactome:R-HSA-1268020|reactome:R-HSA-168277|reactome:R-HSA-180897|reactome:R-HSA-83936|refseq:NP_001627.2 go:"GO:0005739"(mitochondrion) - - figure legend:Fig 5B, Supp. Table 2|comment:Cluster 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606 rogid:K5zi7otVqbL4Z4NHyHB1nojLOTg9606 intact-crc:20ECAEA7F17F2C57|rigid:B6F8qDNkuXsPPT2aCFeLNUrNUEw false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05141 uniprotkb:Q96I36 intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671 intact:EBI-6570698|ensembl:ENSP00000326052|ensembl:ENSP00000446524|ensembl:ENSP00000447776|ensembl:ENSP00000450331|uniprotkb:B2R5G6 psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym) psi-mi:cox14_human(display_long)|uniprotkb:COX14(gene name)|psi-mi:COX14(display_short)|uniprotkb:C12orf62(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656154|imex:IM-18725-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N ensembl:ENSG00000178449(gene)|ensembl:ENST00000317943(transcript)|ensembl:ENST00000548985(transcript)|ensembl:ENST00000550487(transcript)|ensembl:ENST00000550654(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR029208|reactome:R-HSA-5628897|reactome:R-HSA-611105|refseq:NP_001244062.1|refseq:NP_001244063.1|refseq:NP_116290.1|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig 5B, Supp. Table 2|comment:Cluster 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606 rogid:Vr9NrwDWz608Cjy6WwQjZup1bKQ9606 intact-crc:20ECAEA7F17F2C57|rigid:B6F8qDNkuXsPPT2aCFeLNUrNUEw false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05141 uniprotkb:P00395 intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656154|imex:IM-18725-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig 5B, Supp. Table 2|comment:Cluster 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 intact-crc:20ECAEA7F17F2C57|rigid:B6F8qDNkuXsPPT2aCFeLNUrNUEw false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05141 uniprotkb:Q7Z7K0 intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671 intact:EBI-6570685|uniprotkb:Q68DJ7|ensembl:ENSP00000418348 psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym) psi-mi:coxm1_human(display_long)|uniprotkb:CMC1(gene name)|psi-mi:CMC1(display_short)|uniprotkb:C3orf68(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656154|imex:IM-18725-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N refseq:NP_872329.1|ensembl:ENSG00000187118(gene)|ensembl:ENST00000466830(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0046872"(metal ion binding)|interpro:IPR013892(Protein of unknown function UPF0287) go:"GO:0005739"(mitochondrion) - - figure legend:Fig 5B, Supp. Table 2|comment:Cluster 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606 rogid:XLpcUQKNCUyL+bnDHXL5ibCYqLg9606 intact-crc:20ECAEA7F17F2C57|rigid:B6F8qDNkuXsPPT2aCFeLNUrNUEw false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05141 uniprotkb:Q8NBN7 intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671 intact:EBI-3922765|uniprotkb:Q96G88|uniprotkb:Q6UX79|ensembl:ENSP00000391121|ensembl:ENSP00000477512 psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym) psi-mi:rdh13_human(display_long)|uniprotkb:RDH13(gene name)|psi-mi:RDH13(display_short)|uniprotkb:SDR7C3(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 7C member 3(gene name synonym)|uniprotkb:PSEC0082(orf name)|uniprotkb:UNQ736/PRO1430(orf name) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656154|imex:IM-18725-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N refseq:XP_011524709.1|refseq:NP_001139443.1|refseq:NP_612421.1|ensembl:ENSG00000160439(gene)|ensembl:ENST00000615256(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0009644"(response to high light intensity)|go:"GO:0010842"(retina layer formation)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042574"(retinal metabolic process)|go:"GO:0052650"(NADP-retinol dehydrogenase activity)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:Q8NBN7|reactome:R-HSA-5365859|ensembl:ENSG00000276684(gene)|ensembl:ENST00000415061(transcript)|refseq:XP_005258530.1 go:"GO:0005739"(mitochondrion) - - figure legend:Fig 5B, Supp. Table 2|comment:Cluster 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606 rogid:UHfrKddjwiPXJ6xohB99Ua0jGZo9606 intact-crc:20ECAEA7F17F2C57|rigid:B6F8qDNkuXsPPT2aCFeLNUrNUEw false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05141 uniprotkb:Q9NQ50 intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671 intact:EBI-1053902|uniprotkb:O95134|ensembl:ENSP00000333401|uniprotkb:B3KVZ7 psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym) psi-mi:rm40_human(display_long)|uniprotkb:Nuclear localization signal-containing protein deleted in velocardiofacial syndrome(gene name synonym)|uniprotkb:Up-regulated in metastasis(gene name synonym)|uniprotkb:MRPL40(gene name)|psi-mi:MRPL40(display_short)|uniprotkb:NLVCF(gene name synonym)|uniprotkb:URIM(gene name synonym)|uniprotkb:Mitochondrial large ribosomal subunit protein mL40(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656154|imex:IM-18725-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N ensembl:ENSG00000185608(gene)|ensembl:ENST00000333130(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0009653"(anatomical structure morphogenesis)|interpro:IPR019192|interpro:IPR039145|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|refseq:NP_003767.2|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|rcsb pdb:6ZSG|reactome:R-HSA-5389840|reactome:R-HSA-5419276 go:"GO:0005739"(mitochondrion) - - figure legend:Fig 5B, Supp. Table 2|comment:Cluster 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606 rogid:1puL0njSb72Xpg43i1ZEAL/l8DU9606 intact-crc:20ECAEA7F17F2C57|rigid:B6F8qDNkuXsPPT2aCFeLNUrNUEw false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05141 uniprotkb:Q9H2W6 intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671 intact:EBI-6393565|ensembl:ENSP00000312311|uniprotkb:B2RD75|uniprotkb:Q9HBU8 psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym) psi-mi:rm46_human(display_long)|uniprotkb:Mitochondrial large ribosomal subunit protein mL46(gene name synonym)|uniprotkb:MRPL46(gene name)|psi-mi:MRPL46(display_short)|uniprotkb:C15orf4(gene name synonym)|uniprotkb:LIECG2(gene name synonym)|uniprotkb:P2ECSL(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656154|imex:IM-18725-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N ensembl:ENSG00000259494(gene)|ensembl:ENST00000312475(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030054"(cell junction)|interpro:IPR015797(NUDIX)|interpro:IPR021757|interpro:IPR033650|interpro:IPR040008|mint:Q9H2W6|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|rcsb pdb:7A5K|reactome:R-HSA-5419276|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|refseq:NP_071446.2 go:"GO:0005739"(mitochondrion) - - figure legend:Fig 5B, Supp. Table 2|comment:Cluster 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606 rogid:7u4sNH/MVFnEZRMjr7ey6d8WpfM9606 intact-crc:20ECAEA7F17F2C57|rigid:B6F8qDNkuXsPPT2aCFeLNUrNUEw false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05141 uniprotkb:Q96GC5 intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671 intact:EBI-5325315|ensembl:ENSP00000308717|uniprotkb:Q49AK7|uniprotkb:Q4U2Q4|uniprotkb:Q9P091|uniprotkb:Q9Y5J0|intact:EBI-10967301|uniprotkb:B4DN34 psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym) psi-mi:rm48_human(display_long)|uniprotkb:Mitochondrial large ribosomal subunit protein mL48(gene name synonym)|uniprotkb:CGI-118(orf name)|uniprotkb:HSPC290(orf name)|uniprotkb:MRPL48(gene name)|psi-mi:MRPL48(display_short) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656154|imex:IM-18725-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N ensembl:ENSG00000175581(gene)|ensembl:ENST00000310614(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|interpro:IPR027486|interpro:IPR027487|mint:Q96GC5|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|interpro:IPR036838|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:6ZSG|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:7OF6|refseq:NP_001305427.1|refseq:NP_001305428.1|refseq:NP_001305429.1|refseq:NP_057139.1 go:"GO:0005739"(mitochondrion) - - figure legend:Fig 5B, Supp. Table 2|comment:Cluster 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606 rogid:xCdGuctoVF3DrDHZedpDi+IOxxQ9606 intact-crc:20ECAEA7F17F2C57|rigid:B6F8qDNkuXsPPT2aCFeLNUrNUEw false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05141 uniprotkb:Q8N5G0 intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671 intact:EBI-6570855|ensembl:ENSP00000427407|uniprotkb:C9JYT8|uniprotkb:Q9BRT5 psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym) psi-mi:sim20_human(display_long)|uniprotkb:SMIM20(gene name)|psi-mi:SMIM20(display_short)|uniprotkb:C4orf52(gene name synonym)|uniprotkb:MITRAC7(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 7 kDa(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656154|imex:IM-18725-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N ensembl:ENSG00000250317(gene)|ensembl:ENST00000506197(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR027917|mint:Q8N5G0|refseq:NP_001138904.1 go:"GO:0005739"(mitochondrion) - - figure legend:Fig 5B, Supp. Table 2|comment:Cluster 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606 rogid:yqRjpvlmOpU7RfsXACpQ7ytSFZE9606 intact-crc:20ECAEA7F17F2C57|rigid:B6F8qDNkuXsPPT2aCFeLNUrNUEw false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05141 uniprotkb:Q15526 intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671 intact:EBI-3915286|uniprotkb:Q5T8T3|uniprotkb:Q5T8T4|ensembl:ENSP00000361042|ensembl:ENSP00000487158 psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym) psi-mi:surf1_human(display_long)|uniprotkb:SURF1(gene name)|psi-mi:SURF1(display_short)|uniprotkb:SURF-1(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656154|imex:IM-18725-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N refseq:NP_003163.1|refseq:NP_001267716.1|ensembl:ENSG00000148290(gene)|ensembl:ENSG00000280627(gene)|ensembl:ENST00000371974(transcript)|ensembl:ENST00000626663(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR002994(Surfeit locus 1)|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig 5B, Supp. Table 2|comment:Cluster 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606 rogid:HGpXJhbeMdDuz7amqIgWqxlHicA9606 intact-crc:20ECAEA7F17F2C57|rigid:B6F8qDNkuXsPPT2aCFeLNUrNUEw false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05141 uniprotkb:Q9BVV7 intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671 intact:EBI-6570759|uniprotkb:Q9P010|ensembl:ENSP00000169551 psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym) psi-mi:tim21_human(display_long)|uniprotkb:TIMM21(gene name)|psi-mi:TIMM21(display_short)|uniprotkb:TIM21-like protein, mitochondrial(gene name synonym)|uniprotkb:HSPC154(orf name)|uniprotkb:C18orf55(gene name synonym)|uniprotkb:TIM21(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656154|imex:IM-18725-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N ensembl:ENSG00000075336(gene)|ensembl:ENST00000169551(transcript)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR013261(Mitochondrial import inner membrane translocase, subunit Tim21)|interpro:IPR038552|reactome:R-HSA-1268020|refseq:NP_054896.2 go:"GO:0005739"(mitochondrion) - - figure legend:Fig 5B, Supp. Table 2|comment:Cluster 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606 rogid:/iiwo2Ow/n6nP6pWgf/QI/V8CNg9606 intact-crc:20ECAEA7F17F2C57|rigid:B6F8qDNkuXsPPT2aCFeLNUrNUEw false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05141 uniprotkb:A0PJW6 intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671 intact:EBI-6570796|uniprotkb:Q504S0|uniprotkb:Q86YD4|uniprotkb:Q8WUC5|uniprotkb:Q96HG0|ensembl:ENSP00000303987 psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym) psi-mi:tm223_human(display_long)|uniprotkb:TMEM223(gene name)|psi-mi:TMEM223(display_short) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656154|imex:IM-18725-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N refseq:NP_001073970.1|ensembl:ENSG00000168569(gene)|ensembl:ENST00000307366(transcript)|go:"GO:0007399"(nervous system development)|go:"GO:0016021"(integral component of membrane)|interpro:IPR026100 go:"GO:0005739"(mitochondrion) - - figure legend:Fig 5B, Supp. Table 2|comment:Cluster 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2016/12/06 rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606 rogid:lAHosIG6Gfn6JCOdAHXz/TPYyLE9606 intact-crc:20ECAEA7F17F2C57|rigid:B6F8qDNkuXsPPT2aCFeLNUrNUEw false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UJS0 uniprotkb:P00403 intact:EBI-1222503|uniprotkb:O14566|uniprotkb:O14575|uniprotkb:Q9NZW1|uniprotkb:Q9UNI7|uniprotkb:Q546F9|ensembl:ENSP00000265631 intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876 psi-mi:cmc2_human(display_long)|uniprotkb:SLC25A13(gene name)|psi-mi:SLC25A13(display_short)|uniprotkb:ARALAR2(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym) psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656170|imex:IM-18725-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055066.1|refseq:NP_001153682.1|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9UJS0|rcsb pdb:4P5W|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693|ensembl:ENSG00000004864(gene)|ensembl:ENST00000265631(transcript) refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:YtrKzkRujsJ/hzl2bJaLgJAAswI9606 rogid:NyMmciQe53E935KEZahz8cGPjIM9606 intact-crc:556285FD8FDF99C0|rigid:e+pj7odY0ZMBZRjqT7b8xqJZKeg false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UJS0 uniprotkb:P00414 intact:EBI-1222503|uniprotkb:O14566|uniprotkb:O14575|uniprotkb:Q9NZW1|uniprotkb:Q9UNI7|uniprotkb:Q546F9|ensembl:ENSP00000265631 intact:EBI-3932264|uniprotkb:Q14Y83|ensembl:ENSP00000354982 psi-mi:cmc2_human(display_long)|uniprotkb:SLC25A13(gene name)|psi-mi:SLC25A13(display_short)|uniprotkb:ARALAR2(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym) psi-mi:cox3_human(display_long)|uniprotkb:MT-CO3(gene name)|psi-mi:MT-CO3(display_short)|uniprotkb:COIII(gene name synonym)|uniprotkb:COXIII(gene name synonym)|uniprotkb:MTCO3(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide III(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656170|imex:IM-18725-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055066.1|refseq:NP_001153682.1|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9UJS0|rcsb pdb:4P5W|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693|ensembl:ENSG00000004864(gene)|ensembl:ENST00000265631(transcript) ensembl:ENSG00000198938(gene)|ensembl:ENST00000362079(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015453"(oxidoreduction-driven active transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045277"(respiratory chain complex IV)|interpro:IPR000298(Cytochrome c oxidase, subunit III)|interpro:IPR013833(Cytochrome c oxidase, subunit III, 4-helical bundle)|interpro:IPR024791|interpro:IPR033945|interpro:IPR035973|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|refseq:YP_003024032.1 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:YtrKzkRujsJ/hzl2bJaLgJAAswI9606 rogid:ZsGHu+XXEfFZZecGf4EIhwQejAA9606 intact-crc:556285FD8FDF99C0|rigid:e+pj7odY0ZMBZRjqT7b8xqJZKeg false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UJS0 uniprotkb:P13073 intact:EBI-1222503|uniprotkb:O14566|uniprotkb:O14575|uniprotkb:Q9NZW1|uniprotkb:Q9UNI7|uniprotkb:Q546F9|ensembl:ENSP00000265631 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:cmc2_human(display_long)|uniprotkb:SLC25A13(gene name)|psi-mi:SLC25A13(display_short)|uniprotkb:ARALAR2(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656170|imex:IM-18725-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055066.1|refseq:NP_001153682.1|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9UJS0|rcsb pdb:4P5W|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693|ensembl:ENSG00000004864(gene)|ensembl:ENST00000265631(transcript) refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:YtrKzkRujsJ/hzl2bJaLgJAAswI9606 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 intact-crc:556285FD8FDF99C0|rigid:e+pj7odY0ZMBZRjqT7b8xqJZKeg false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UJS0 uniprotkb:P20674 intact:EBI-1222503|uniprotkb:O14566|uniprotkb:O14575|uniprotkb:Q9NZW1|uniprotkb:Q9UNI7|uniprotkb:Q546F9|ensembl:ENSP00000265631 intact:EBI-715032|uniprotkb:P30045|intact:EBI-1043629|uniprotkb:Q8TB65|ensembl:ENSP00000317780|ensembl:ENSP00000456386 psi-mi:cmc2_human(display_long)|uniprotkb:SLC25A13(gene name)|psi-mi:SLC25A13(display_short)|uniprotkb:ARALAR2(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym) psi-mi:cox5a_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Va(gene name synonym)|uniprotkb:COX5A(gene name)|psi-mi:COX5A(display_short) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656170|imex:IM-18725-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055066.1|refseq:NP_001153682.1|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9UJS0|rcsb pdb:4P5W|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693|ensembl:ENSG00000004864(gene)|ensembl:ENST00000265631(transcript) refseq:NP_004246.2|interpro:IPR003204(Cytochrome c oxidase, subunit Va)|interpro:IPR036545|mint:P20674|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000178741(gene)|ensembl:ENST00000322347(transcript)|ensembl:ENST00000564811(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity) go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:YtrKzkRujsJ/hzl2bJaLgJAAswI9606 rogid:dWvZKYawyJQwN29Mhkm44DXXqhg9606 intact-crc:556285FD8FDF99C0|rigid:e+pj7odY0ZMBZRjqT7b8xqJZKeg false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UJS0 uniprotkb:P09669 intact:EBI-1222503|uniprotkb:O14566|uniprotkb:O14575|uniprotkb:Q9NZW1|uniprotkb:Q9UNI7|uniprotkb:Q546F9|ensembl:ENSP00000265631 intact:EBI-715040|uniprotkb:B2R4D7|ensembl:ENSP00000297564|ensembl:ENSP00000428150|ensembl:ENSP00000428702|ensembl:ENSP00000428895|ensembl:ENSP00000428965|ensembl:ENSP00000429410|ensembl:ENSP00000429707|ensembl:ENSP00000429714|ensembl:ENSP00000429755|ensembl:ENSP00000429991 psi-mi:cmc2_human(display_long)|uniprotkb:SLC25A13(gene name)|psi-mi:SLC25A13(display_short)|uniprotkb:ARALAR2(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym) psi-mi:cox6c_human(display_long)|uniprotkb:COX6C(gene name)|psi-mi:COX6C(display_short)|uniprotkb:Cytochrome c oxidase polypeptide VIc(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656170|imex:IM-18725-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055066.1|refseq:NP_001153682.1|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9UJS0|rcsb pdb:4P5W|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693|ensembl:ENSG00000004864(gene)|ensembl:ENST00000265631(transcript) refseq:NP_004365.1|refseq:XP_016868509.1|ensembl:ENSG00000164919(gene)|ensembl:ENST00000297564(transcript)|ensembl:ENST00000517682(transcript)|ensembl:ENST00000518171(transcript)|ensembl:ENST00000520271(transcript)|ensembl:ENST00000520468(transcript)|ensembl:ENST00000520517(transcript)|ensembl:ENST00000522934(transcript)|ensembl:ENST00000522940(transcript)|ensembl:ENST00000523016(transcript)|ensembl:ENST00000524245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004204(Cytochrome c oxidase subunit VIc)|interpro:IPR034884|interpro:IPR037169|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0006091"(generation of precursor metabolites and energy) go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:YtrKzkRujsJ/hzl2bJaLgJAAswI9606 rogid:Zha4dqasvkWw3ACebJNflgxCVKo9606 intact-crc:556285FD8FDF99C0|rigid:e+pj7odY0ZMBZRjqT7b8xqJZKeg false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UJS0 uniprotkb:P24311 intact:EBI-1222503|uniprotkb:O14566|uniprotkb:O14575|uniprotkb:Q9NZW1|uniprotkb:Q9UNI7|uniprotkb:Q546F9|ensembl:ENSP00000265631 intact:EBI-2684371|uniprotkb:Q6ICR1|uniprotkb:B2R4M3|ensembl:ENSP00000497474 psi-mi:cmc2_human(display_long)|uniprotkb:SLC25A13(gene name)|psi-mi:SLC25A13(display_short)|uniprotkb:ARALAR2(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym) psi-mi:cox7b_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide VIIb(gene name synonym)|uniprotkb:COX7B(gene name)|psi-mi:COX7B(display_short) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656170|imex:IM-18725-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055066.1|refseq:NP_001153682.1|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9UJS0|rcsb pdb:4P5W|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693|ensembl:ENSG00000004864(gene)|ensembl:ENST00000265631(transcript) refseq:NP_001857.1|ensembl:ENSG00000131174(gene)|ensembl:ENST00000650309(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0007417"(central nervous system development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045277"(respiratory chain complex IV)|interpro:IPR008433(Cytochrome C oxidase chain VIIB)|interpro:IPR023272|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:YtrKzkRujsJ/hzl2bJaLgJAAswI9606 rogid:V9AcoXkMThm2bVNnVka9GHOVrfk9606 intact-crc:556285FD8FDF99C0|rigid:e+pj7odY0ZMBZRjqT7b8xqJZKeg false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UJS0 uniprotkb:P14854 intact:EBI-1222503|uniprotkb:O14566|uniprotkb:O14575|uniprotkb:Q9NZW1|uniprotkb:Q9UNI7|uniprotkb:Q546F9|ensembl:ENSP00000265631 intact:EBI-1047480|uniprotkb:Q6IBL4|uniprotkb:B2R5C9|ensembl:ENSP00000376037|ensembl:ENSP00000466818|ensembl:ENSP00000497926 psi-mi:cmc2_human(display_long)|uniprotkb:SLC25A13(gene name)|psi-mi:SLC25A13(display_short)|uniprotkb:ARALAR2(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym) psi-mi:cx6b1_human(display_long)|uniprotkb:COX6B1(gene name)|psi-mi:COX6B1(display_short)|uniprotkb:COX6B(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIb isoform 1(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656170|imex:IM-18725-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055066.1|refseq:NP_001153682.1|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9UJS0|rcsb pdb:4P5W|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693|ensembl:ENSG00000004864(gene)|ensembl:ENST00000265631(transcript) refseq:NP_001854.1|ensembl:ENSG00000126267(gene)|ensembl:ENST00000392201(transcript)|ensembl:ENST00000592141(transcript)|ensembl:ENST00000649813(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0021762"(substantia nigra development)|go:"GO:0045277"(respiratory chain complex IV)|interpro:IPR003213(Cytochrome c oxidase, subunit VIb)|interpro:IPR036549|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:YtrKzkRujsJ/hzl2bJaLgJAAswI9606 rogid:YuBPGRO9+EC9fWz+mWALa2DyZL89606 intact-crc:556285FD8FDF99C0|rigid:e+pj7odY0ZMBZRjqT7b8xqJZKeg false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UJS0 uniprotkb:P14406 intact:EBI-1222503|uniprotkb:O14566|uniprotkb:O14575|uniprotkb:Q9NZW1|uniprotkb:Q9UNI7|uniprotkb:Q546F9|ensembl:ENSP00000265631 intact:EBI-2606666|uniprotkb:Q5TF59|uniprotkb:Q6FGI2|uniprotkb:Q3MIH5|uniprotkb:B2R5E1|ensembl:ENSP00000506727 psi-mi:cmc2_human(display_long)|uniprotkb:SLC25A13(gene name)|psi-mi:SLC25A13(display_short)|uniprotkb:ARALAR2(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym) psi-mi:cx7a2_human(display_long)|uniprotkb:COX7AL(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIIa-liver/heart(gene name synonym)|uniprotkb:COX7A2(gene name)|psi-mi:COX7A2(display_short) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656170|imex:IM-18725-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055066.1|refseq:NP_001153682.1|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9UJS0|rcsb pdb:4P5W|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693|ensembl:ENSG00000004864(gene)|ensembl:ENST00000265631(transcript) refseq:NP_001856.2|ensembl:ENSG00000112695(gene)|ensembl:ENST00000684430(transcript)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0097250"(mitochondrial respirasome assembly)|interpro:IPR003177(Cytochrome c oxidase, subunit VIIa)|interpro:IPR036539|interpro:IPR039297|mint:P14406|rcsb pdb:5Z62 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:YtrKzkRujsJ/hzl2bJaLgJAAswI9606 rogid:krjTK658npBV4G6gH28GJhVqBkY9606 intact-crc:556285FD8FDF99C0|rigid:e+pj7odY0ZMBZRjqT7b8xqJZKeg false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UJS0 uniprotkb:O00483 intact:EBI-1222503|uniprotkb:O14566|uniprotkb:O14575|uniprotkb:Q9NZW1|uniprotkb:Q9UNI7|uniprotkb:Q546F9|ensembl:ENSP00000265631 intact:EBI-1049381|uniprotkb:Q6FHN5|uniprotkb:A4D109|ensembl:ENSP00000339720 psi-mi:cmc2_human(display_long)|uniprotkb:SLC25A13(gene name)|psi-mi:SLC25A13(display_short)|uniprotkb:ARALAR2(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym) psi-mi:ndua4_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase MLRQ subunit(gene name synonym)|uniprotkb:Complex I-MLRQ(gene name synonym)|uniprotkb:NDUFA4(gene name)|psi-mi:NDUFA4(display_short) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656170|imex:IM-18725-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055066.1|refseq:NP_001153682.1|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9UJS0|rcsb pdb:4P5W|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693|ensembl:ENSG00000004864(gene)|ensembl:ENST00000265631(transcript) refseq:NP_002480.1|ensembl:ENSG00000189043(gene)|ensembl:ENST00000339600(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1904960"(positive regulation of cytochrome-c oxidase activity)|interpro:IPR010530(B12D)|mint:O00483|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:YtrKzkRujsJ/hzl2bJaLgJAAswI9606 rogid:TnrYlkH8abl42/yGsvfc8Bh6Mu09606 intact-crc:556285FD8FDF99C0|rigid:e+pj7odY0ZMBZRjqT7b8xqJZKeg false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UJS0 uniprotkb:Q8N490 intact:EBI-1222503|uniprotkb:O14566|uniprotkb:O14575|uniprotkb:Q9NZW1|uniprotkb:Q9UNI7|uniprotkb:Q546F9|ensembl:ENSP00000265631 intact:EBI-746368|uniprotkb:Q96A48|uniprotkb:Q9BU26|uniprotkb:Q9NSX4|uniprotkb:Q9ULN6|uniprotkb:Q9Y4T1|uniprotkb:A8K1F2|ensembl:ENSP00000273077 psi-mi:cmc2_human(display_long)|uniprotkb:SLC25A13(gene name)|psi-mi:SLC25A13(display_short)|uniprotkb:ARALAR2(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym) psi-mi:pnkd_human(display_long)|uniprotkb:Paroxysmal nonkinesiogenic dyskinesia protein(gene name synonym)|uniprotkb:Myofibrillogenesis regulator 1(gene name synonym)|uniprotkb:Trans-activated by hepatitis C virus core protein 2(gene name synonym)|uniprotkb:PNKD(gene name)|psi-mi:PNKD(display_short)|uniprotkb:KIAA1184(gene name synonym)|uniprotkb:MR1(gene name synonym)|uniprotkb:TAHCCP2(gene name synonym)|uniprotkb:FKSG19(orf name)|uniprotkb:UNQ2491/PRO5778(orf name) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656170|imex:IM-18725-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055066.1|refseq:NP_001153682.1|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9UJS0|rcsb pdb:4P5W|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693|ensembl:ENSG00000004864(gene)|ensembl:ENST00000265631(transcript) refseq:NP_001070867.1|refseq:NP_056303.3|refseq:NP_072094.1|ensembl:ENST00000273077(transcript)|go:"GO:0004416"(hydroxyacylglutathione hydrolase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0016020"(membrane)|go:"GO:0019243"(methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0050884"(neuromuscular process controlling posture)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR017782(Hydroxyacylglutathione hydrolase)|interpro:IPR032282|interpro:IPR035680|interpro:IPR036866|ensembl:ENSG00000127838(gene) go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:YtrKzkRujsJ/hzl2bJaLgJAAswI9606 rogid:LKItPq0mJBGgqEeDl3LoJAeTAl09606 intact-crc:556285FD8FDF99C0|rigid:e+pj7odY0ZMBZRjqT7b8xqJZKeg false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UJS0 uniprotkb:O75880 intact:EBI-1222503|uniprotkb:O14566|uniprotkb:O14575|uniprotkb:Q9NZW1|uniprotkb:Q9UNI7|uniprotkb:Q546F9|ensembl:ENSP00000265631 intact:EBI-6656171|ensembl:ENSP00000255390|uniprotkb:B2RDM0 psi-mi:cmc2_human(display_long)|uniprotkb:SLC25A13(gene name)|psi-mi:SLC25A13(display_short)|uniprotkb:ARALAR2(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym) psi-mi:sco1_human(display_long)|uniprotkb:SCO1(gene name)|psi-mi:SCO1(display_short)|uniprotkb:SCOD1(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656170|imex:IM-18725-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055066.1|refseq:NP_001153682.1|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9UJS0|rcsb pdb:4P5W|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693|ensembl:ENSG00000004864(gene)|ensembl:ENST00000265631(transcript) ensembl:ENSG00000133028(gene)|ensembl:ENST00000255390(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0016531"(copper chaperone activity)|go:"GO:0030016"(myofibril)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR003782(Copper chaperone SCO1/SenC)|interpro:IPR017276(Synthesis of cytochrome c oxidase, Sco1/Sco2)|interpro:IPR036249|rcsb pdb:1WP0|rcsb pdb:2GGT|rcsb pdb:2GQK|rcsb pdb:2GQL|rcsb pdb:2GQM|rcsb pdb:2GT5|rcsb pdb:2GT6|rcsb pdb:2GVP|rcsb pdb:2HRF|rcsb pdb:2HRN|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|refseq:NP_004580.1|dip:DIP-46086N|refseq:XP_005256808.1 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp Table 2|comment:Cluster 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:YtrKzkRujsJ/hzl2bJaLgJAAswI9606 rogid:oxGxX5mXuGDP5uPIW1vyOtaQHxU9606 intact-crc:556285FD8FDF99C0|rigid:e+pj7odY0ZMBZRjqT7b8xqJZKeg false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZN9 uniprotkb:Q02978 intact:EBI-3248549|ensembl:ENSP00000016171|uniprotkb:Q7Z3Q3|uniprotkb:O75878|uniprotkb:Q5TD00|uniprotkb:O60556|uniprotkb:A8K6I9|uniprotkb:Q5TD01|uniprotkb:Q9NTN0 intact:EBI-359174|uniprotkb:O75537|uniprotkb:Q969P7|ensembl:ENSP00000225665|uniprotkb:F5GY65 psi-mi:cox15_human(display_long)|uniprotkb:COX15(gene name)|psi-mi:COX15(display_short) psi-mi:m2om_human(display_long)|uniprotkb:SLC25A11(gene name)|psi-mi:SLC25A11(display_short)|uniprotkb:SLC20A4(gene name synonym)|uniprotkb:Solute carrier family 25 member 11(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656225|imex:IM-18725-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000014919(gene)|ensembl:ENST00000016171(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-HSA-189451|refseq:NP_004367.2|refseq:NP_510870.1|refseq:NP_001307903.1|refseq:NP_001307904.1|refseq:NP_001307905.1 refseq:NP_003553.2|go:"GO:0071423"(malate transmembrane transport)|interpro:IPR018108|interpro:IPR023395|mint:Q02978|reactome:R-HSA-70263|ensembl:ENSG00000108528(gene)|ensembl:ENST00000225665(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008272"(sulfate transport)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015117"(thiosulfate transmembrane transporter activity)|go:"GO:0015131"(oxaloacetate transmembrane transporter activity)|go:"GO:0015140"(malate transmembrane transporter activity)|go:"GO:0015141"(succinate transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0015367"("oxoglutarate:malate antiporter activity")|go:"GO:0015709"(thiosulfate transport)|go:"GO:0015729"(oxaloacetate transport)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0071422"(succinate transmembrane transport) go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp. Table 2|comment:Cluster 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:wdz9gN+Wa6J/2OWm1flGDTmR7vM9606 rogid:TPeF6k/rQq+WJ9omeDK4V6NY4/o9606 intact-crc:4CE0868BBFF8E064|rigid:wplW+TzO31HX3YonFNshQhF7FwA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZN9 uniprotkb:Q00325 intact:EBI-3248549|ensembl:ENSP00000016171|uniprotkb:Q7Z3Q3|uniprotkb:O75878|uniprotkb:Q5TD00|uniprotkb:O60556|uniprotkb:A8K6I9|uniprotkb:Q5TD01|uniprotkb:Q9NTN0 intact:EBI-358549|uniprotkb:Q96A03|intact:EBI-28967087|ensembl:ENSP00000228318|ensembl:ENSP00000447310|uniprotkb:Q7Z7N7|uniprotkb:B3KS34 psi-mi:cox15_human(display_long)|uniprotkb:COX15(gene name)|psi-mi:COX15(display_short) psi-mi:mpcp_human(display_long)|uniprotkb:SLC25A3(gene name)|psi-mi:SLC25A3(display_short)|uniprotkb:PHC(gene name synonym)|uniprotkb:OK/SW-cl.48(orf name)|uniprotkb:Phosphate transport protein(gene name synonym)|uniprotkb:Solute carrier family 25 member 3(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656225|imex:IM-18725-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000014919(gene)|ensembl:ENST00000016171(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-HSA-189451|refseq:NP_004367.2|refseq:NP_510870.1|refseq:NP_001307903.1|refseq:NP_001307904.1|refseq:NP_001307905.1 ensembl:ENST00000188376|ensembl:ENSP00000188376|ensembl:ENSP00000228318|ensembl:ENST00000401722|ensembl:ENSP00000383898|ensembl:ENST00000549338|ensembl:ENSP00000447740|ensembl:ENSP00000447310|ensembl:ENST00000552981|ensembl:ENSP00000448708|refseq:NP_002626.1|refseq:NP_005879.1|refseq:NP_998776.1|ensembl:ENSG00000075415(gene)|ensembl:ENST00000228318(transcript)|ensembl:ENST00000551917(transcript)|go:"GO:0005315"(inorganic phosphate transmembrane transporter activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015317"("phosphate:proton symporter activity")|go:"GO:0016020"(membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990547"(mitochondrial phosphate ion transmembrane transport)|interpro:IPR018108|interpro:IPR023395|interpro:IPR044677|mint:Q00325 go:"GO:0005739"(mitochondrion) - crc64:78714C85931B22D5 figure legend:Fig. 5B, Supp. Table 2|comment:Cluster 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:wdz9gN+Wa6J/2OWm1flGDTmR7vM9606 rogid:f8THTDwNPyGowC9gCT9ZsizQ6qs9606 intact-crc:4CE0868BBFF8E064|rigid:wplW+TzO31HX3YonFNshQhF7FwA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZN9 uniprotkb:Q6P1L8 intact:EBI-3248549|ensembl:ENSP00000016171|uniprotkb:Q7Z3Q3|uniprotkb:O75878|uniprotkb:Q5TD00|uniprotkb:O60556|uniprotkb:A8K6I9|uniprotkb:Q5TD01|uniprotkb:Q9NTN0 intact:EBI-1043903|ensembl:ENSP00000361084|uniprotkb:Q96Q72|uniprotkb:B2R575 psi-mi:cox15_human(display_long)|uniprotkb:COX15(gene name)|psi-mi:COX15(display_short) psi-mi:rm14_human(display_long)|uniprotkb:MRPL14(gene name)|psi-mi:MRPL14(display_short)|uniprotkb:RPML32(gene name synonym)|uniprotkb:MRPL32(gene name synonym)|uniprotkb:39S ribosomal protein L32, mitochondrial(gene name synonym)|uniprotkb:Mitochondrial large ribosomal subunit protein uL14m(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656225|imex:IM-18725-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000014919(gene)|ensembl:ENST00000016171(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-HSA-189451|refseq:NP_004367.2|refseq:NP_510870.1|refseq:NP_001307903.1|refseq:NP_001307904.1|refseq:NP_001307905.1 ensembl:ENSG00000180992(gene)|ensembl:ENST00000372014(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR000218(Ribosomal protein L14b/L23e)|interpro:IPR036853|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_115487.2|refseq:NP_001305696.1|refseq:NP_001305697.1 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp. Table 2|comment:Cluster 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:wdz9gN+Wa6J/2OWm1flGDTmR7vM9606 rogid:Iwh7qhYEwAsJk6e9hA2IiCcvey09606 intact-crc:4CE0868BBFF8E064|rigid:wplW+TzO31HX3YonFNshQhF7FwA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZN9 uniprotkb:Q6NUK1 intact:EBI-3248549|ensembl:ENSP00000016171|uniprotkb:Q7Z3Q3|uniprotkb:O75878|uniprotkb:Q5TD00|uniprotkb:O60556|uniprotkb:A8K6I9|uniprotkb:Q5TD01|uniprotkb:Q9NTN0 intact:EBI-4289949|uniprotkb:Q705K4|uniprotkb:B7ZAI9|uniprotkb:Q5T331|uniprotkb:Q9P129|uniprotkb:Q5T485|uniprotkb:Q6PJJ9|ensembl:ENSP00000457733|ensembl:ENSP00000491572 psi-mi:cox15_human(display_long)|uniprotkb:COX15(gene name)|psi-mi:COX15(display_short) psi-mi:scmc1_human(display_long)|uniprotkb:SLC25A24(gene name)|psi-mi:SLC25A24(display_short)|uniprotkb:APC1(gene name synonym)|uniprotkb:MCSC1(gene name synonym)|uniprotkb:SCAMC1(gene name synonym)|uniprotkb:Mitochondrial ATP-Mg/Pi carrier protein 1(gene name synonym)|uniprotkb:"Mitochondrial Ca(2+)-dependent solute carrier protein 1"(gene name synonym)|uniprotkb:Small calcium-binding mitochondrial carrier protein 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 24(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656225|imex:IM-18725-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000014919(gene)|ensembl:ENST00000016171(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-HSA-189451|refseq:NP_004367.2|refseq:NP_510870.1|refseq:NP_001307903.1|refseq:NP_001307904.1|refseq:NP_001307905.1 refseq:NP_037518.3|refseq:NP_998816.1|ensembl:ENSG00000085491(gene)|ensembl:ENSG00000284468(gene)|ensembl:ENST00000565488(transcript)|ensembl:ENST00000640416(transcript)|go:"GO:0005347"(ATP transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0010941"(regulation of cell death)|go:"GO:0015867"(ATP transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002167(Graves disease carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR018247|interpro:IPR023395|mint:Q6NUK1|rcsb pdb:4N5X|rcsb pdb:4ZCU|rcsb pdb:4ZCV go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp. Table 2|comment:Cluster 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:wdz9gN+Wa6J/2OWm1flGDTmR7vM9606 rogid:2zVynZiDVY5UzziL6TAmqK/fkB09606 intact-crc:4CE0868BBFF8E064|rigid:wplW+TzO31HX3YonFNshQhF7FwA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZN9 uniprotkb:Q9H9B4 intact:EBI-3248549|ensembl:ENSP00000016171|uniprotkb:Q7Z3Q3|uniprotkb:O75878|uniprotkb:Q5TD00|uniprotkb:O60556|uniprotkb:A8K6I9|uniprotkb:Q5TD01|uniprotkb:Q9NTN0 intact:EBI-355861|uniprotkb:Q9HA53|uniprotkb:B3KPW3|uniprotkb:D3DQN2|ensembl:ENSP00000316905 psi-mi:cox15_human(display_long)|uniprotkb:COX15(gene name)|psi-mi:COX15(display_short) psi-mi:sfxn1_human(display_long)|uniprotkb:SFXN1(gene name)|psi-mi:SFXN1(display_short) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656225|imex:IM-18725-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000014919(gene)|ensembl:ENST00000016171(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-HSA-189451|refseq:NP_004367.2|refseq:NP_510870.1|refseq:NP_001307903.1|refseq:NP_001307904.1|refseq:NP_001307905.1 refseq:NP_073591.2|refseq:NP_001309906.1|ensembl:ENSG00000164466(gene)|ensembl:ENST00000321442(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0015194"(L-serine transmembrane transporter activity)|go:"GO:0015825"(L-serine transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0022889"(serine transmembrane transporter activity)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0042942"(D-serine transport)|go:"GO:0042945"(D-serine transmembrane transporter activity)|go:"GO:0140300"(serine import into mitochondrion)|go:"GO:1990542"(mitochondrial transmembrane transport)|interpro:IPR004686(Tricarboxylate/iron carrier)|mint:Q9H9B4 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp. Table 2|comment:Cluster 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:wdz9gN+Wa6J/2OWm1flGDTmR7vM9606 rogid:n/i6d8Rt+xMOvu3BrZfc0VP0+Wk9606 intact-crc:4CE0868BBFF8E064|rigid:wplW+TzO31HX3YonFNshQhF7FwA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZN9 uniprotkb:Q6P4A7 intact:EBI-3248549|ensembl:ENSP00000016171|uniprotkb:Q7Z3Q3|uniprotkb:O75878|uniprotkb:Q5TD00|uniprotkb:O60556|uniprotkb:A8K6I9|uniprotkb:Q5TD01|uniprotkb:Q9NTN0 intact:EBI-1049439|uniprotkb:Q6WSU4|uniprotkb:Q86TD9|ensembl:ENSP00000347924 psi-mi:cox15_human(display_long)|uniprotkb:COX15(gene name)|psi-mi:COX15(display_short) psi-mi:sfxn4_human(display_long)|uniprotkb:Breast cancer resistance marker 1(gene name synonym)|uniprotkb:SFXN4(gene name)|psi-mi:SFXN4(display_short)|uniprotkb:BCRM1(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656225|imex:IM-18725-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000014919(gene)|ensembl:ENST00000016171(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-HSA-189451|refseq:NP_004367.2|refseq:NP_510870.1|refseq:NP_001307903.1|refseq:NP_001307904.1|refseq:NP_001307905.1 refseq:NP_998814.1|refseq:XP_011537584.1|refseq:XP_005269583.1|refseq:XP_005269584.1|ensembl:ENSG00000183605(gene)|ensembl:ENST00000355697(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006865"(amino acid transport)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:1990542"(mitochondrial transmembrane transport)|interpro:IPR004686(Tricarboxylate/iron carrier)|interpro:IPR028825 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp. Table 2|comment:Cluster 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:wdz9gN+Wa6J/2OWm1flGDTmR7vM9606 rogid:D/Ae1Kd5aIiliqNVmS7aFaIpwsk9606 intact-crc:4CE0868BBFF8E064|rigid:wplW+TzO31HX3YonFNshQhF7FwA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZN9 uniprotkb:Q3ZCQ8 intact:EBI-3248549|ensembl:ENSP00000016171|uniprotkb:Q7Z3Q3|uniprotkb:O75878|uniprotkb:Q5TD00|uniprotkb:O60556|uniprotkb:A8K6I9|uniprotkb:Q5TD01|uniprotkb:Q9NTN0 intact:EBI-355175|uniprotkb:Q6QA00|uniprotkb:Q96FJ5|uniprotkb:Q96GY2|uniprotkb:Q9H370|intact:EBI-2554785|uniprotkb:Q330K1|ensembl:ENSP00000475531 psi-mi:cox15_human(display_long)|uniprotkb:COX15(gene name)|psi-mi:COX15(display_short) psi-mi:tim50_human(display_long)|uniprotkb:TIMM50(gene name)|psi-mi:TIMM50(display_short)|uniprotkb:TIM50(gene name synonym)|uniprotkb:PRO1512(orf name) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656225|imex:IM-18725-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000014919(gene)|ensembl:ENST00000016171(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-HSA-189451|refseq:NP_004367.2|refseq:NP_510870.1|refseq:NP_001307903.1|refseq:NP_001307904.1|refseq:NP_001307905.1 refseq:NP_001001563.1|ensembl:ENSG00000105197(gene)|ensembl:ENST00000607714(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0043021"(ribonucleoprotein complex binding)|interpro:IPR004274(NLI interacting factor)|interpro:IPR023214|interpro:IPR027111|interpro:IPR036412|mint:Q3ZCQ8|reactome:R-HSA-1268020|refseq:NP_001316488.1|dip:DIP-34058N go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp. Table 2|comment:Cluster 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:wdz9gN+Wa6J/2OWm1flGDTmR7vM9606 rogid:fOPV33h12YhAq9jj0bVno01Q+6g9606 intact-crc:4CE0868BBFF8E064|rigid:wplW+TzO31HX3YonFNshQhF7FwA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZN9 uniprotkb:Q6PI78 intact:EBI-3248549|ensembl:ENSP00000016171|uniprotkb:Q7Z3Q3|uniprotkb:O75878|uniprotkb:Q5TD00|uniprotkb:O60556|uniprotkb:A8K6I9|uniprotkb:Q5TD01|uniprotkb:Q9NTN0 intact:EBI-6656213|ensembl:ENSP00000297632|uniprotkb:Q8N5G8|uniprotkb:Q8WVK5 psi-mi:cox15_human(display_long)|uniprotkb:COX15(gene name)|psi-mi:COX15(display_short) psi-mi:tmm65_human(display_long)|uniprotkb:TMEM65(gene name)|psi-mi:TMEM65(display_short) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656225|imex:IM-18725-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000014919(gene)|ensembl:ENST00000016171(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-HSA-189451|refseq:NP_004367.2|refseq:NP_510870.1|refseq:NP_001307903.1|refseq:NP_001307904.1|refseq:NP_001307905.1 go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0016021"(integral component of membrane)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR019537|ensembl:ENSG00000164983(gene)|ensembl:ENST00000297632(transcript)|go:"GO:0003231"(cardiac ventricle development)|refseq:NP_919267.2 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp. Table 2|comment:Cluster 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:wdz9gN+Wa6J/2OWm1flGDTmR7vM9606 rogid:WPwheAbhf1OxtAf2KVEwCIPYr1o9606 intact-crc:4CE0868BBFF8E064|rigid:wplW+TzO31HX3YonFNshQhF7FwA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZN9 uniprotkb:Q9HC21 intact:EBI-3248549|ensembl:ENSP00000016171|uniprotkb:Q7Z3Q3|uniprotkb:O75878|uniprotkb:Q5TD00|uniprotkb:O60556|uniprotkb:A8K6I9|uniprotkb:Q5TD01|uniprotkb:Q9NTN0 intact:EBI-6268699|ensembl:ENSP00000319574|ensembl:ENSP00000385312|ensembl:ENSP00000397818|ensembl:ENSP00000402202|ensembl:ENSP00000463795|intact:EBI-10978418|uniprotkb:E9PF74|uniprotkb:Q6V9R7 psi-mi:cox15_human(display_long)|uniprotkb:COX15(gene name)|psi-mi:COX15(display_short) psi-mi:tpc_human(display_long)|uniprotkb:SLC25A19(gene name)|psi-mi:SLC25A19(display_short)|uniprotkb:DNC(gene name synonym)|uniprotkb:MUP1(gene name synonym)|uniprotkb:Mitochondrial uncoupling protein 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 19(gene name synonym) psi-mi:"MI:0276"(blue native page) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6656225|imex:IM-18725-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000014919(gene)|ensembl:ENST00000016171(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-HSA-189451|refseq:NP_004367.2|refseq:NP_510870.1|refseq:NP_001307903.1|refseq:NP_001307904.1|refseq:NP_001307905.1 ensembl:ENSG00000125454(gene)|ensembl:ENST00000320362(transcript)|ensembl:ENST00000402418(transcript)|ensembl:ENST00000416858(transcript)|ensembl:ENST00000442286(transcript)|ensembl:ENST00000580994(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0015234"(thiamine transmembrane transporter activity)|go:"GO:0030233"(deoxynucleotide transmembrane transporter activity)|go:"GO:0030302"(deoxynucleotide transport)|go:"GO:0030974"(thiamine pyrophosphate transmembrane transport)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0042723"(thiamine-containing compound metabolic process)|go:"GO:0090422"(thiamine pyrophosphate transmembrane transporter activity)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR018108|interpro:IPR023395|reactome:R-HSA-196819|refseq:XP_005257616.1|refseq:XP_005257617.1|refseq:XP_005257618.1|refseq:XP_005257619.1|refseq:NP_001119593.1|refseq:NP_001119594.1|refseq:NP_068380.3|refseq:XP_006722070.1|refseq:XP_016880415.1 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 5B, Supp. Table 2|comment:Cluster 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:wdz9gN+Wa6J/2OWm1flGDTmR7vM9606 rogid:+jRNNjAOfOymBAHTtdDt8p/+41Q9606 intact-crc:4CE0868BBFF8E064|rigid:wplW+TzO31HX3YonFNshQhF7FwA false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2R0 uniprotkb:P00395 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570495|imex:IM-18725-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 1F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 intact-crc:0F78FDAC4894F020|rigid:KcytpbUe+ww0DFpCzyAsjiJkcfM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y2R0 uniprotkb:Q15526 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 intact:EBI-3915286|uniprotkb:Q5T8T3|uniprotkb:Q5T8T4|ensembl:ENSP00000361042|ensembl:ENSP00000487158 psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:surf1_human(display_long)|uniprotkb:SURF1(gene name)|psi-mi:SURF1(display_short)|uniprotkb:SURF-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Mick et al. (2012) imex:IM-18725|pubmed:23260140 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6570495|imex:IM-18725-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 refseq:NP_003163.1|refseq:NP_001267716.1|ensembl:ENSG00000148290(gene)|ensembl:ENSG00000280627(gene)|ensembl:ENST00000371974(transcript)|ensembl:ENST00000626663(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|interpro:IPR002994(Surfeit locus 1)|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 go:"GO:0005739"(mitochondrion) - - figure legend:Fig. 1F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2013/03/26 2014/10/16 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rogid:HGpXJhbeMdDuz7amqIgWqxlHicA9606 intact-crc:0F78FDAC4894F020|rigid:KcytpbUe+ww0DFpCzyAsjiJkcfM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)