#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q4KL25	uniprotkb:Q99PJ1	intact:EBI-6556731|ensembl:ENSMUSP00000079598|ensembl:ENSMUSP00000156557|ensembl:ENSMUSP00000156959|uniprotkb:B2KF30	intact:EBI-6556746|uniprotkb:D6RCH0|uniprotkb:E9Q7D7|uniprotkb:E9Q7R2|uniprotkb:F6KJX4|uniprotkb:F6KKG6|uniprotkb:F6R5Z7|uniprotkb:F6RBV2|uniprotkb:F6U3Q6|uniprotkb:F6UPC9|uniprotkb:F6VPR3|uniprotkb:F6WUN7|uniprotkb:F6X715|uniprotkb:F6XPA1|uniprotkb:F6Y0A5|uniprotkb:F6YP25|uniprotkb:F6YZQ9|uniprotkb:F7ASH0|uniprotkb:F7CIN1|uniprotkb:F7D5J8|uniprotkb:F7DFU0|uniprotkb:F8VQ61|uniprotkb:H3BKS0|uniprotkb:Q0ZM15|uniprotkb:Q0ZM16|uniprotkb:Q0ZM18|uniprotkb:Q0ZM19|uniprotkb:Q0ZM20|uniprotkb:Q0ZM21|uniprotkb:Q0ZM22|uniprotkb:Q0ZM23|uniprotkb:Q0ZM24|uniprotkb:Q0ZM25|uniprotkb:Q0ZM26|uniprotkb:Q0ZM27|uniprotkb:Q0ZM28|uniprotkb:Q0ZM29|uniprotkb:Q0ZM30|uniprotkb:Q0ZM31|uniprotkb:Q0ZM32|uniprotkb:Q0ZM33|uniprotkb:Q0ZM34|uniprotkb:Q0ZM35|uniprotkb:Q0ZM37|uniprotkb:Q2VQG7|uniprotkb:Q3URZ1|uniprotkb:Q3UTS7|ensembl:ENSMUSP00000141792|uniprotkb:E9Q7R1	psi-mi:lhpl5_mouse(display_long)|uniprotkb:Lhfpl5(gene name)|psi-mi:Lhfpl5(display_short)|uniprotkb:Tmhs(gene name synonym)|uniprotkb:Lipoma HMGIC fusion partner-like 5 protein(gene name synonym)|uniprotkb:Tetraspan membrane protein of hair cell stereocilia(gene name synonym)	psi-mi:pcd15_mouse(display_long)|uniprotkb:Pcdh15(gene name)|psi-mi:Pcdh15(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xiong et al. (2012)	imex:IM-18711|pubmed:23217710	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6556730|imex:IM-18711-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000062252(gene)|ensembl:ENSMUST00000080780(transcript)|ensembl:ENSMUST00000232862(transcript)|ensembl:ENSMUST00000232974(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|interpro:IPR019372|rcsb pdb:6C14|refseq:NP_080847.2	ensembl:ENSMUSG00000052613(gene)|ensembl:ENSMUST00000193361(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001964"(startle response)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032420"(stereocilium)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048839"(inner ear development)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0050973"(detection of mechanical stimulus involved in equilibrioception)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060013"(righting reflex)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR030718|interpro:IPR041149|mint:Q99PJ1|rcsb pdb:4APX|rcsb pdb:4AQ8|rcsb pdb:4AQA|rcsb pdb:4AQE|rcsb pdb:4AXW|rcsb pdb:4XXW|rcsb pdb:5KJ4|rcsb pdb:5W1D|rcsb pdb:6BWN|rcsb pdb:6C10|rcsb pdb:6C13|rcsb pdb:6C14|rcsb pdb:6CV7|rcsb pdb:6EET|rcsb pdb:6N22|rcsb pdb:5TPK|refseq:XP_006513219.1|refseq:NP_075604.2|refseq:NP_001136207.1|refseq:NP_001136208.1|refseq:NP_001136209.1|refseq:NP_001136210.1|refseq:NP_001136211.1|refseq:NP_001136212.1|refseq:NP_001136213.1|refseq:NP_001136214.1|refseq:NP_001136215.1|refseq:NP_001136218.1|refseq:NP_001136219.1|refseq:NP_001136220.1|refseq:NP_001136232.1|dip:DIP-42151N	-	-	-	figure legend:Fig. 3C, 3D, 4D|comment:The cytoplasmic region of the PCDH15 molecule could be divided into the CD3 and CR sub-regions, both of which appeared to interact with TMHS, but these could not be mapped to specific coordinates.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/03/11	2014/10/16	rogid:u3hZdNg5NqT5TyhEVaiPU8mzxec10090	rogid:Hg/g9gB38Qx+yyHMlcicxTlTvmA10090	intact-crc:06E1E9163AC89A4C|rigid:Xtf6Ywbs7IzK5O74JJV9YpqfqX4	false	ha tag:?-?	sufficient binding region:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q4KL25	uniprotkb:Q99PJ1	intact:EBI-6556731|ensembl:ENSMUSP00000079598|ensembl:ENSMUSP00000156557|ensembl:ENSMUSP00000156959|uniprotkb:B2KF30	intact:EBI-6556746|uniprotkb:D6RCH0|uniprotkb:E9Q7D7|uniprotkb:E9Q7R2|uniprotkb:F6KJX4|uniprotkb:F6KKG6|uniprotkb:F6R5Z7|uniprotkb:F6RBV2|uniprotkb:F6U3Q6|uniprotkb:F6UPC9|uniprotkb:F6VPR3|uniprotkb:F6WUN7|uniprotkb:F6X715|uniprotkb:F6XPA1|uniprotkb:F6Y0A5|uniprotkb:F6YP25|uniprotkb:F6YZQ9|uniprotkb:F7ASH0|uniprotkb:F7CIN1|uniprotkb:F7D5J8|uniprotkb:F7DFU0|uniprotkb:F8VQ61|uniprotkb:H3BKS0|uniprotkb:Q0ZM15|uniprotkb:Q0ZM16|uniprotkb:Q0ZM18|uniprotkb:Q0ZM19|uniprotkb:Q0ZM20|uniprotkb:Q0ZM21|uniprotkb:Q0ZM22|uniprotkb:Q0ZM23|uniprotkb:Q0ZM24|uniprotkb:Q0ZM25|uniprotkb:Q0ZM26|uniprotkb:Q0ZM27|uniprotkb:Q0ZM28|uniprotkb:Q0ZM29|uniprotkb:Q0ZM30|uniprotkb:Q0ZM31|uniprotkb:Q0ZM32|uniprotkb:Q0ZM33|uniprotkb:Q0ZM34|uniprotkb:Q0ZM35|uniprotkb:Q0ZM37|uniprotkb:Q2VQG7|uniprotkb:Q3URZ1|uniprotkb:Q3UTS7|ensembl:ENSMUSP00000141792|uniprotkb:E9Q7R1	psi-mi:lhpl5_mouse(display_long)|uniprotkb:Lhfpl5(gene name)|psi-mi:Lhfpl5(display_short)|uniprotkb:Tmhs(gene name synonym)|uniprotkb:Lipoma HMGIC fusion partner-like 5 protein(gene name synonym)|uniprotkb:Tetraspan membrane protein of hair cell stereocilia(gene name synonym)	psi-mi:pcd15_mouse(display_long)|uniprotkb:Pcdh15(gene name)|psi-mi:Pcdh15(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Xiong et al. (2012)	imex:IM-18711|pubmed:23217710	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6556859|imex:IM-18711-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000062252(gene)|ensembl:ENSMUST00000080780(transcript)|ensembl:ENSMUST00000232862(transcript)|ensembl:ENSMUST00000232974(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|interpro:IPR019372|rcsb pdb:6C14|refseq:NP_080847.2	ensembl:ENSMUSG00000052613(gene)|ensembl:ENSMUST00000193361(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001964"(startle response)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032420"(stereocilium)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048839"(inner ear development)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0050973"(detection of mechanical stimulus involved in equilibrioception)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060013"(righting reflex)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR030718|interpro:IPR041149|mint:Q99PJ1|rcsb pdb:4APX|rcsb pdb:4AQ8|rcsb pdb:4AQA|rcsb pdb:4AQE|rcsb pdb:4AXW|rcsb pdb:4XXW|rcsb pdb:5KJ4|rcsb pdb:5W1D|rcsb pdb:6BWN|rcsb pdb:6C10|rcsb pdb:6C13|rcsb pdb:6C14|rcsb pdb:6CV7|rcsb pdb:6EET|rcsb pdb:6N22|rcsb pdb:5TPK|refseq:XP_006513219.1|refseq:NP_075604.2|refseq:NP_001136207.1|refseq:NP_001136208.1|refseq:NP_001136209.1|refseq:NP_001136210.1|refseq:NP_001136211.1|refseq:NP_001136212.1|refseq:NP_001136213.1|refseq:NP_001136214.1|refseq:NP_001136215.1|refseq:NP_001136218.1|refseq:NP_001136219.1|refseq:NP_001136220.1|refseq:NP_001136232.1|dip:DIP-42151N	go:"GO:0005886"(plasma membrane)	-	-	caution:The hurry-scurry mutation is described in the figure legend 4E to be Tyr161Cys, in all other sources, including the remainder of this paper, it is Cys161Phe, which correlates with the given sequence so the legend to 4E has been assumed to be an error.|figure legend:Fig. 4Ad–4Ai, 4E|comment:TMHS carrying the hurry-scurry mutation in  still colocalized with PCDH15, but the protein complex remained in aggregates within the cytoplasm.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpmi2650)|taxid:9606(Human nasal septum carcinoma cell line RPMI-2650)	-	2013/03/11	2014/10/16	rogid:u3hZdNg5NqT5TyhEVaiPU8mzxec10090	rogid:Hg/g9gB38Qx+yyHMlcicxTlTvmA10090	intact-crc:998CA28989A0C82D|rigid:Xtf6Ywbs7IzK5O74JJV9YpqfqX4	false	mutation:161-161	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)