#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P13010	uniprotkb:Q8IW19	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Grundy et al. (2013)	pubmed:23178593|mint:MINT-8412483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8166851|mint:MINT-8412604	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|mint:MINT-8412607(identity)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ|mint:MINT-8412606(identity)	-	-	-	figure legend:f1a|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/01/29	2014/10/16	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	intact-crc:9DBF7538B1710080|rigid:FW9pG96LLwEhLkwG1ggpKwrOHi8	false	fusion protein:?-?(MINT-8412609)	fusion protein:?-?(MINT-8412613)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IW19	uniprotkb:Q13426	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	intact:EBI-717592|uniprotkb:Q9BS72|uniprotkb:Q9UP94|uniprotkb:A8K3X4|ensembl:ENSP00000342011|ensembl:ENSP00000421491	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:xrcc4_human(display_long)|uniprotkb:X-ray repair cross-complementing protein 4(gene name synonym)|uniprotkb:XRCC4(gene name)|psi-mi:XRCC4(display_short)	psi-mi:"MI:0018"(two hybrid)	Grundy et al. (2013)	pubmed:23178593|mint:MINT-8412483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8166912|mint:MINT-8412631	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ|mint:MINT-8412637(identity)	refseq:NP_003392.1|refseq:NP_071801.1|refseq:NP_072044.1|refseq:NP_001304941.1|refseq:NP_001304942.1|refseq:XP_011541928.1|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010165"(response to X-ray)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0070975"(FHA domain binding)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:1990166"(protein localization to site of double-strand break)|interpro:IPR009089(DNA double-strand break repair and VJ recombination XRCC4, N-terminal)|interpro:IPR010585(DNA double-strand break repair and VJ recombination XRCC4)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR038051|mint:Q13426|rcsb pdb:1FU1|rcsb pdb:1IK9|rcsb pdb:3II6|rcsb pdb:3MUD|rcsb pdb:3Q4F|rcsb pdb:3RWR|rcsb pdb:3SR2|go:"GO:0005737"(cytoplasm)|rcsb pdb:3W03|rcsb pdb:4XA4|rcsb pdb:5CHX|rcsb pdb:5CJ0|rcsb pdb:5CJ4|rcsb pdb:5E50|rcsb pdb:5WJ7|rcsb pdb:5WLZ|rcsb pdb:6ABO|rcsb pdb:7LSY|rcsb pdb:7LT3|rcsb pdb:7M3P|reactome:R-HSA-164843|reactome:R-HSA-3108214|reactome:R-HSA-5693571|ensembl:ENSG00000152422(gene)|ensembl:ENST00000338635(transcript)|ensembl:ENST00000511817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|dip:DIP-37957N|mint:MINT-8412633(identity)	-	-	-	figure legend:f1a|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/01/29	2014/10/16	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	rogid:qWdX2yBKXcwYG7vQpss9MIaFWU89606	intact-crc:C76348E5EBB8A901|rigid:/SsbF6pf0XdCflrJrKxJPBPoN+k	false	fusion protein:?-?(MINT-8412638)	fusion protein:?-?(MINT-8412634)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P18887	uniprotkb:Q8IW19	intact:EBI-947466|uniprotkb:Q9HCB1|uniprotkb:Q6IBS4|ensembl:ENSP00000262887	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	psi-mi:xrcc1_human(display_long)|uniprotkb:XRCC1(gene name)|psi-mi:XRCC1(display_short)|uniprotkb:X-ray repair cross-complementing protein 1(gene name synonym)	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Grundy et al. (2013)	pubmed:23178593|mint:MINT-8412483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8166895|mint:MINT-8412618	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006288.2|dip:DIP-39067N|ensembl:ENSG00000073050(gene)|ensembl:ENST00000262887(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010033"(response to organic substance)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0032356"(oxidized DNA binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904877"(positive regulation of DNA ligase activity)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990599"(3' overhang single-stranded DNA endodeoxyribonuclease activity)|interpro:IPR001357(BRCT)|interpro:IPR002706(DNA-repair protein Xrcc1, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036420|mint:P18887|rcsb pdb:1CDZ|rcsb pdb:1XNA|rcsb pdb:1XNT|rcsb pdb:2D8M|rcsb pdb:2W3O|rcsb pdb:3K75|rcsb pdb:3K77|rcsb pdb:3LQC|rcsb pdb:5E6Q|rcsb pdb:5W7X|rcsb pdb:5W7Y|reactome:R-HSA-110381|reactome:R-HSA-5649702|reactome:R-HSA-5685939|reactome:R-HSA-5696397|reactome:R-HSA-6782210|mint:MINT-8412620(identity)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ|mint:MINT-8412624(identity)	-	-	-	figure legend:f1a|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/01/29	2014/10/16	rogid:96hETrBzHYhHX9FC5dZpKnFcjDg9606	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	intact-crc:26240989011E2320|rigid:0NPkIA/ltpJ3aJubYceZcyY7N6s	false	fusion protein:?-?(MINT-8412621)	fusion protein:?-?(MINT-8412625)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13010	uniprotkb:Q8IW19	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Grundy et al. (2013)	pubmed:23178593|mint:MINT-8412483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8166929|mint:MINT-8412645	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|mint:MINT-8412647(identity)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ|mint:MINT-8412651(identity)	-	-	-	figure legend:f1b|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/01/29	2014/10/16	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	intact-crc:4D6ADB57BFF3217B|rigid:FW9pG96LLwEhLkwG1ggpKwrOHi8	false	fusion protein:?-?(MINT-8412648)	fusion protein:?-?(MINT-8412652)|mutation disrupting interaction:189-189(MINT-8412668)|binding-associated region:94-358(MINT-8412665)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IW19	uniprotkb:P13010	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Grundy et al. (2013)	pubmed:23178593|mint:MINT-8412483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8167009|mint:MINT-8412861	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ|mint:MINT-8412871(identity)	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|mint:MINT-8412863(identity)	-	-	-	figure legend:f4b|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/01/29	2014/10/16	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	intact-crc:03353BCC0B8A1439|rigid:FW9pG96LLwEhLkwG1ggpKwrOHi8	false	fusion protein:?-?(MINT-8412872)|binding-associated region:94-358(MINT-8412874)	fusion protein:?-?(MINT-8412868)|binding-associated region:1-258(MINT-8412866)|mutation disrupting interaction:74-74(MINT-8412864)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13010	uniprotkb:Q8IW19	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Grundy et al. (2013)	pubmed:23178593|mint:MINT-8412483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8166981|mint:MINT-8412838	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|mint:MINT-8412848(identity)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ|mint:MINT-8412840(identity)	-	-	-	figure legend:f4b|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/01/29	2014/10/16	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	intact-crc:249BFA29AE4D8BD6|rigid:FW9pG96LLwEhLkwG1ggpKwrOHi8	false	binding-associated region:1-258(MINT-8412855)|fusion protein:?-?(MINT-8412849)|mutation disrupting interaction:68-68(MINT-8412857)	fusion protein:?-?(MINT-8412845)|binding-associated region:94-358(MINT-8412843)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13010	uniprotkb:Q8IW19	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Grundy et al. (2013)	pubmed:23178593|mint:MINT-8412483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8167092|mint:MINT-8412899	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|mint:MINT-8412901(identity)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ|mint:MINT-8412909(identity)	-	-	-	figure legend:f4b|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/01/29	2014/10/16	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	intact-crc:D87F58B7CE850AC3|rigid:FW9pG96LLwEhLkwG1ggpKwrOHi8	false	mutation decreasing interaction:169-169(MINT-8412902)|binding-associated region:1-258(MINT-8412904)|fusion protein:?-?(MINT-8412906)	binding-associated region:94-358(MINT-8412912)|fusion protein:?-?(MINT-8412910)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13010	uniprotkb:Q8IW19	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Grundy et al. (2013)	pubmed:23178593|mint:MINT-8412483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8167037|mint:MINT-8412880	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|mint:MINT-8412888(identity)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ|mint:MINT-8412882(identity)	-	-	-	figure legend:f4b|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/01/29	2014/10/16	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	intact-crc:A4D6615FF9903391|rigid:FW9pG96LLwEhLkwG1ggpKwrOHi8	false	binding-associated region:1-258(MINT-8412891)|mutation disrupting interaction:112-112(MINT-8412893)|fusion protein:?-?(MINT-8412889)	fusion protein:?-?(MINT-8412885)|binding-associated region:94-358(MINT-8412883)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IW19	uniprotkb:P49917	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	intact:EBI-847896|uniprotkb:Q8TEU5|uniprotkb:Q8IY66|ensembl:ENSP00000385955|ensembl:ENSP00000402030|ensembl:ENSP00000484288	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:dnli4_human(display_long)|uniprotkb:DNA ligase IV(gene name synonym)|uniprotkb:Polydeoxyribonucleotide synthase [ATP] 4(gene name synonym)|uniprotkb:LIG4(gene name)|psi-mi:LIG4(display_short)	psi-mi:"MI:0049"(filter binding)	Grundy et al. (2013)	pubmed:23178593|mint:MINT-8412483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8167140|mint:MINT-8412696	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ|mint:MINT-8412698(identity)	refseq:XP_006720014.1|refseq:XP_006720015.1|refseq:NP_001091738.1|refseq:NP_002303.2|refseq:NP_996820.1|refseq:XP_016876060.1|refseq:XP_016876058.1|refseq:XP_016876059.1|dip:DIP-37958N|refseq:XP_011519393.1|refseq:XP_011519394.1|refseq:XP_005254113.1|refseq:XP_005254114.1|refseq:XP_005254115.1|refseq:NP_001317524.1|refseq:XP_016876062.1|ensembl:ENSG00000174405(gene)|ensembl:ENST00000405925(transcript)|ensembl:ENST00000442234(transcript)|ensembl:ENST00000611712(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003909"(DNA ligase activity)|go:"GO:0003910"("DNA ligase (ATP) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006266"(DNA ligation)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007049"(cell cycle)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016874"(ligase activity)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045190"(isotype switching)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051102"(DNA ligation involved in DNA recombination)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:2001252"(positive regulation of chromosome organization)|interpro:IPR000977(ATP-dependent DNA ligase)|interpro:IPR001357(BRCT)|interpro:IPR012308(DNA ligase, N-terminal)|interpro:IPR012309(ATP dependent DNA ligase, C-terminal)|interpro:IPR012310(ATP dependent DNA ligase, central)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR016059(ATP-dependent DNA ligase, conserved site)|interpro:IPR021536|interpro:IPR029710|interpro:IPR036420|interpro:IPR036599|interpro:IPR044125|mint:P49917|rcsb pdb:1IK9|rcsb pdb:2E2W|rcsb pdb:3II6|rcsb pdb:3VNN|rcsb pdb:3W1B|rcsb pdb:3W1G|rcsb pdb:3W5O|rcsb pdb:4HTO|rcsb pdb:4HTP|rcsb pdb:6BKF|rcsb pdb:6BKG|rcsb pdb:7D9K|rcsb pdb:7D9Y|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-5693571|mint:MINT-8412706(identity)	-	-	-	figure legend:f1d|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/01/29	2014/10/16	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	rogid:ISugsd4sAk8gxR8n4GCk3ZkPijo9606	intact-crc:A81FFD3D18A75BC7|rigid:wLcuBTtSNQtzw6imRjw8QxdRqck	false	binding-associated region:1-346(MINT-8412699)	his tag:?-?(MINT-8412707)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IW19	uniprotkb:Q13426	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	intact:EBI-717592|uniprotkb:Q9BS72|uniprotkb:Q9UP94|uniprotkb:A8K3X4|ensembl:ENSP00000342011|ensembl:ENSP00000421491	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:xrcc4_human(display_long)|uniprotkb:X-ray repair cross-complementing protein 4(gene name synonym)|uniprotkb:XRCC4(gene name)|psi-mi:XRCC4(display_short)	psi-mi:"MI:0049"(filter binding)	Grundy et al. (2013)	pubmed:23178593|mint:MINT-8412483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8167140|mint:MINT-8412696	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ|mint:MINT-8412698(identity)	refseq:NP_003392.1|refseq:NP_071801.1|refseq:NP_072044.1|refseq:NP_001304941.1|refseq:NP_001304942.1|refseq:XP_011541928.1|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010165"(response to X-ray)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0051103"(DNA ligation involved in DNA repair)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0070975"(FHA domain binding)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:1905782"(positive regulation of phosphatidylserine exposure on apoptotic cell surface)|go:"GO:1990166"(protein localization to site of double-strand break)|interpro:IPR009089(DNA double-strand break repair and VJ recombination XRCC4, N-terminal)|interpro:IPR010585(DNA double-strand break repair and VJ recombination XRCC4)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR038051|mint:Q13426|rcsb pdb:1FU1|rcsb pdb:1IK9|rcsb pdb:3II6|rcsb pdb:3MUD|rcsb pdb:3Q4F|rcsb pdb:3RWR|rcsb pdb:3SR2|go:"GO:0005737"(cytoplasm)|rcsb pdb:3W03|rcsb pdb:4XA4|rcsb pdb:5CHX|rcsb pdb:5CJ0|rcsb pdb:5CJ4|rcsb pdb:5E50|rcsb pdb:5WJ7|rcsb pdb:5WLZ|rcsb pdb:6ABO|rcsb pdb:7LSY|rcsb pdb:7LT3|rcsb pdb:7M3P|reactome:R-HSA-164843|reactome:R-HSA-3108214|reactome:R-HSA-5693571|ensembl:ENSG00000152422(gene)|ensembl:ENST00000338635(transcript)|ensembl:ENST00000511817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|dip:DIP-37957N|mint:MINT-8412702(identity)	-	-	-	figure legend:f1d|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/01/29	2014/10/16	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	rogid:qWdX2yBKXcwYG7vQpss9MIaFWU89606	intact-crc:A81FFD3D18A75BC7|rigid:wLcuBTtSNQtzw6imRjw8QxdRqck	false	binding-associated region:1-346(MINT-8412699)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IW19	uniprotkb:P18887	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	intact:EBI-947466|uniprotkb:Q9HCB1|uniprotkb:Q6IBS4|ensembl:ENSP00000262887	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:xrcc1_human(display_long)|uniprotkb:XRCC1(gene name)|psi-mi:XRCC1(display_short)|uniprotkb:X-ray repair cross-complementing protein 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Grundy et al. (2013)	pubmed:23178593|mint:MINT-8412483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8167126|mint:MINT-8412679	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ|mint:MINT-8412685(identity)	refseq:NP_006288.2|dip:DIP-39067N|ensembl:ENSG00000073050(gene)|ensembl:ENST00000262887(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010033"(response to organic substance)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0032356"(oxidized DNA binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904877"(positive regulation of DNA ligase activity)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990599"(3' overhang single-stranded DNA endodeoxyribonuclease activity)|interpro:IPR001357(BRCT)|interpro:IPR002706(DNA-repair protein Xrcc1, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036420|mint:P18887|rcsb pdb:1CDZ|rcsb pdb:1XNA|rcsb pdb:1XNT|rcsb pdb:2D8M|rcsb pdb:2W3O|rcsb pdb:3K75|rcsb pdb:3K77|rcsb pdb:3LQC|rcsb pdb:5E6Q|rcsb pdb:5W7X|rcsb pdb:5W7Y|reactome:R-HSA-110381|reactome:R-HSA-5649702|reactome:R-HSA-5685939|reactome:R-HSA-5696397|reactome:R-HSA-6782210|mint:MINT-8412681(identity)	-	-	-	figure legend:f1d|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/01/29	2014/10/16	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	rogid:96hETrBzHYhHX9FC5dZpKnFcjDg9606	intact-crc:FB24127F491CB2D0|rigid:0NPkIA/ltpJ3aJubYceZcyY7N6s	false	binding-associated region:1-346(MINT-8412692)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IW19	uniprotkb:P13010	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Grundy et al. (2013)	pubmed:23178593|mint:MINT-8412483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8167229|mint:MINT-8412784	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ|mint:MINT-8412792(identity)	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|mint:MINT-8412786(identity)	-	-	-	figure legend:f1d|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/01/29	2014/10/16	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	intact-crc:A9BF755556150121|rigid:FBIhRfcfOGkEafP5/Vz0nK2vsAw	false	mutation disrupting interaction:183-183(MINT-8412800)|mutation decreasing interaction:184-184(MINT-8412803)|binding-associated region:1-346(MINT-8412795)|mutation disrupting interaction:182-182(MINT-8412793)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IW19	uniprotkb:P12956	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	intact:EBI-353208|ensembl:ENSP00000352257|ensembl:ENSP00000353192|ensembl:ENSP00000384257|intact:EBI-2843064|uniprotkb:Q6FG89|uniprotkb:Q9UCQ2|uniprotkb:Q9UCQ3|intact:EBI-8456785|intact:MINT-8429298|uniprotkb:B1AHC8	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:xrcc6_human(display_long)|uniprotkb:XRCC6(gene name)|psi-mi:XRCC6(display_short)|uniprotkb:G22P1(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 70 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p70(gene name synonym)|uniprotkb:70 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 75 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein XRCC6(gene name synonym)|uniprotkb:X-ray repair complementing defective repair in Chinese hamster cells 6(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 1(gene name synonym)|uniprotkb:5'-deoxyribose-5-phosphate lyase Ku70(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Grundy et al. (2013)	pubmed:23178593|mint:MINT-8412483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8167229|mint:MINT-8412784	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ|mint:MINT-8412792(identity)	go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR006165(DNA helicase, ATP-dependent, Ku70 subunit)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR027388|interpro:IPR036361|interpro:IPR036465|mint:P12956|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1JJR|rcsb pdb:3RZX|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZHA|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|rcsb pdb:6ZHE|rcsb pdb:7AXZ|interpro:IPR003034(DNA-binding SAP)|rcsb pdb:7K0Y|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|ensembl:ENSG00000196419(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006266"(DNA ligation)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|ensembl:ENST00000359308(transcript)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|ensembl:ENST00000360079(transcript)|ensembl:ENST00000405878(transcript)|go:"GO:0016020"(membrane)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030332"(cyclin binding)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|refseq:NP_001460.1|refseq:NP_001275906.1|refseq:NP_001275905.1|dip:DIP-24188N|mint:MINT-8412788(identity)	-	-	-	figure legend:f1d|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/01/29	2014/10/16	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	rogid:45wj3HmNJ4dfVgw0zc2r3AUZ0Dw9606	intact-crc:A9BF755556150121|rigid:FBIhRfcfOGkEafP5/Vz0nK2vsAw	false	mutation disrupting interaction:183-183(MINT-8412800)|mutation decreasing interaction:184-184(MINT-8412803)|binding-associated region:1-346(MINT-8412795)|mutation disrupting interaction:182-182(MINT-8412793)	his tag:?-?(MINT-8412789)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IW19	uniprotkb:P13010	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Grundy et al. (2013)	pubmed:23178593|mint:MINT-8412483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8167160|mint:MINT-8412713	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ|mint:MINT-8412721(identity)	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|mint:MINT-8412715(identity)	-	-	-	figure legend:f1d|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/01/29	2014/10/16	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	intact-crc:0CAEA4DA15416696|rigid:FBIhRfcfOGkEafP5/Vz0nK2vsAw	false	binding-associated region:1-346(MINT-8412722)|mutation disrupting interaction:189-189(MINT-8412777)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IW19	uniprotkb:P12956	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	intact:EBI-353208|ensembl:ENSP00000352257|ensembl:ENSP00000353192|ensembl:ENSP00000384257|intact:EBI-2843064|uniprotkb:Q6FG89|uniprotkb:Q9UCQ2|uniprotkb:Q9UCQ3|intact:EBI-8456785|intact:MINT-8429298|uniprotkb:B1AHC8	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:xrcc6_human(display_long)|uniprotkb:XRCC6(gene name)|psi-mi:XRCC6(display_short)|uniprotkb:G22P1(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 70 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p70(gene name synonym)|uniprotkb:70 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 75 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein XRCC6(gene name synonym)|uniprotkb:X-ray repair complementing defective repair in Chinese hamster cells 6(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 1(gene name synonym)|uniprotkb:5'-deoxyribose-5-phosphate lyase Ku70(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Grundy et al. (2013)	pubmed:23178593|mint:MINT-8412483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8167160|mint:MINT-8412713	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ|mint:MINT-8412721(identity)	go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR006165(DNA helicase, ATP-dependent, Ku70 subunit)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR027388|interpro:IPR036361|interpro:IPR036465|mint:P12956|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1JJR|rcsb pdb:3RZX|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZHA|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|rcsb pdb:6ZHE|rcsb pdb:7AXZ|interpro:IPR003034(DNA-binding SAP)|rcsb pdb:7K0Y|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|ensembl:ENSG00000196419(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006266"(DNA ligation)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|ensembl:ENST00000359308(transcript)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|ensembl:ENST00000360079(transcript)|ensembl:ENST00000405878(transcript)|go:"GO:0016020"(membrane)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030332"(cyclin binding)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|refseq:NP_001460.1|refseq:NP_001275906.1|refseq:NP_001275905.1|dip:DIP-24188N|mint:MINT-8412719(identity)	-	-	-	figure legend:f1d|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/01/29	2014/10/16	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	rogid:45wj3HmNJ4dfVgw0zc2r3AUZ0Dw9606	intact-crc:0CAEA4DA15416696|rigid:FBIhRfcfOGkEafP5/Vz0nK2vsAw	false	binding-associated region:1-346(MINT-8412722)|mutation disrupting interaction:189-189(MINT-8412777)	his tag:?-?(MINT-8412780)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IW19	uniprotkb:P13010	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Grundy et al. (2013)	pubmed:23178593|mint:MINT-8412483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8167341|mint:MINT-8412808	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ|mint:MINT-8412810(identity)	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|mint:MINT-8412824(identity)	-	-	-	figure legend:f1e|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.58x10^-6(molar)	2013/01/29	2014/10/16	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	intact-crc:818A2414A9A1961F|rigid:FBIhRfcfOGkEafP5/Vz0nK2vsAw	false	mutation disrupting interaction:182-182(MINT-8412817)|mutation decreasing interaction:184-184(MINT-8412811)|mutation disrupting interaction:189-189(MINT-8412835)|binding-associated region:174-191(MINT-8412815)|mutation disrupting interaction:183-183(MINT-8412813)	binding-associated region:1-591(MINT-8412832)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IW19	uniprotkb:P12956	intact:EBI-1256044|uniprotkb:Q53P47|uniprotkb:Q53PB9|uniprotkb:Q53QU0|uniprotkb:A8K476|ensembl:ENSP00000307004	intact:EBI-353208|ensembl:ENSP00000352257|ensembl:ENSP00000353192|ensembl:ENSP00000384257|intact:EBI-2843064|uniprotkb:Q6FG89|uniprotkb:Q9UCQ2|uniprotkb:Q9UCQ3|intact:EBI-8456785|intact:MINT-8429298|uniprotkb:B1AHC8	psi-mi:aplf_human(display_long)|uniprotkb:APLF(gene name)|psi-mi:APLF(display_short)|uniprotkb:C2orf13(gene name synonym)|uniprotkb:PALF(gene name synonym)|uniprotkb:XIP1(gene name synonym)|uniprotkb:Apurinic-apyrimidinic endonuclease APLF(gene name synonym)|uniprotkb:PNK and APTX-like FHA domain-containing protein(gene name synonym)|uniprotkb:XRCC1-interacting protein 1(gene name synonym)	psi-mi:xrcc6_human(display_long)|uniprotkb:XRCC6(gene name)|psi-mi:XRCC6(display_short)|uniprotkb:G22P1(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 70 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p70(gene name synonym)|uniprotkb:70 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 75 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein XRCC6(gene name synonym)|uniprotkb:X-ray repair complementing defective repair in Chinese hamster cells 6(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 1(gene name synonym)|uniprotkb:5'-deoxyribose-5-phosphate lyase Ku70(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Grundy et al. (2013)	pubmed:23178593|mint:MINT-8412483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8167341|mint:MINT-8412808	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-39136N|refseq:NP_775816.1|ensembl:ENSG00000169621(gene)|ensembl:ENST00000303795(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051106"(positive regulation of DNA ligation)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019406|interpro:IPR039253|interpro:IPR041388|mint:Q8IW19|rcsb pdb:2KQB|rcsb pdb:2KQC|rcsb pdb:2KQD|rcsb pdb:2KQE|rcsb pdb:2KUO|rcsb pdb:5E50|rcsb pdb:5W7W|rcsb pdb:5W7X|rcsb pdb:5W7Y|rcsb pdb:6ERF|rcsb pdb:6TYT|rcsb pdb:6TYW|rcsb pdb:6TYZ|mint:MINT-8412810(identity)	go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR006165(DNA helicase, ATP-dependent, Ku70 subunit)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR027388|interpro:IPR036361|interpro:IPR036465|mint:P12956|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1JJR|rcsb pdb:3RZX|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZHA|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|rcsb pdb:6ZHE|rcsb pdb:7AXZ|interpro:IPR003034(DNA-binding SAP)|rcsb pdb:7K0Y|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|ensembl:ENSG00000196419(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006266"(DNA ligation)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|ensembl:ENST00000359308(transcript)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|ensembl:ENST00000360079(transcript)|ensembl:ENST00000405878(transcript)|go:"GO:0016020"(membrane)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030332"(cyclin binding)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|refseq:NP_001460.1|refseq:NP_001275906.1|refseq:NP_001275905.1|dip:DIP-24188N|mint:MINT-8412820(identity)	-	-	-	figure legend:f1e|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.58x10^-6(molar)	2013/01/29	2014/10/16	rogid:0YHQyvOkIvHXVAd0NWp9roD4Pzc9606	rogid:45wj3HmNJ4dfVgw0zc2r3AUZ0Dw9606	intact-crc:818A2414A9A1961F|rigid:FBIhRfcfOGkEafP5/Vz0nK2vsAw	false	mutation disrupting interaction:182-182(MINT-8412817)|mutation decreasing interaction:184-184(MINT-8412811)|mutation disrupting interaction:189-189(MINT-8412835)|binding-associated region:174-191(MINT-8412815)|mutation disrupting interaction:183-183(MINT-8412813)	his tag:?-?(MINT-8412821)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0396"(predetermined participant)