#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P18089	uniprotkb:Q9ULW5	intact:EBI-9077302|uniprotkb:Q4TUH9|uniprotkb:Q53RF2|uniprotkb:Q9BZK0|uniprotkb:A2RUS0|ensembl:ENSP00000480573	intact:EBI-958239|ensembl:ENSP00000210187|uniprotkb:Q6NXS7|intact:EBI-11079157|uniprotkb:Q3L6K5|uniprotkb:B2RAA6	psi-mi:ada2b_human(display_long)|uniprotkb:ADRA2B(gene name)|psi-mi:ADRA2B(display_short)|uniprotkb:ADRA2L1(gene name synonym)|uniprotkb:ADRA2RL1(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C2(gene name synonym)|uniprotkb:Alpha-2B adrenoreceptor(gene name synonym)	psi-mi:rab26_human(display_long)|uniprotkb:RAB26(gene name)|psi-mi:RAB26(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2012)	imex:IM-22910|pubmed:23105096	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-9514576|imex:IM-22910-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000673.2|dip:DIP-61453N|ensembl:ENSG00000274286(gene)|ensembl:ENST00000620793(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0009986"(cell surface)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0030168"(platelet activation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0035624"(receptor transactivation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0051379"(epinephrine binding)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|interpro:IPR000207(Adrenergic receptor, alpha-2B)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2CVA|rcsb pdb:6K41|rcsb pdb:6K42|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-418594|reactome:R-HSA-418597	ensembl:ENSG00000167964(gene)|ensembl:ENST00000210187(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|refseq:NP_055168.2|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019002"(GMP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0035272"(exocrine system development)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0099575"(regulation of protein catabolic process at presynapse, modulating synaptic transmission)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2G6B|reactome:R-HSA-8873719|refseq:NP_001294982.1	-	-	-	figure legend:Fig 6a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/12/18	2017/03/30	rogid:wD58jj343lgoMJQZDBLLT3clak49606	rogid:kcmXxyYkndHxM/lz+XdGXI1qTzY9606	intact-crc:034E06E8238FACE6|rigid:6g3ih4w7gCER8J7J87f0k7dPCnc	false	ha tag:?-?	mutation decreasing interaction strength:77-77|mutation decreasing interaction strength:177-177|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P18089	uniprotkb:Q9ULW5	intact:EBI-9077302|uniprotkb:Q4TUH9|uniprotkb:Q53RF2|uniprotkb:Q9BZK0|uniprotkb:A2RUS0|ensembl:ENSP00000480573	intact:EBI-958239|ensembl:ENSP00000210187|uniprotkb:Q6NXS7|intact:EBI-11079157|uniprotkb:Q3L6K5|uniprotkb:B2RAA6	psi-mi:ada2b_human(display_long)|uniprotkb:ADRA2B(gene name)|psi-mi:ADRA2B(display_short)|uniprotkb:ADRA2L1(gene name synonym)|uniprotkb:ADRA2RL1(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C2(gene name synonym)|uniprotkb:Alpha-2B adrenoreceptor(gene name synonym)	psi-mi:rab26_human(display_long)|uniprotkb:RAB26(gene name)|psi-mi:RAB26(display_short)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Li et al. (2012)	imex:IM-22910|pubmed:23105096	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1262"(I2D)	intact:EBI-9515352|imex:IM-22910-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000673.2|dip:DIP-61453N|ensembl:ENSG00000274286(gene)|ensembl:ENST00000620793(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0009986"(cell surface)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0030168"(platelet activation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0035624"(receptor transactivation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0051379"(epinephrine binding)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|interpro:IPR000207(Adrenergic receptor, alpha-2B)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2CVA|rcsb pdb:6K41|rcsb pdb:6K42|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-418594|reactome:R-HSA-418597	ensembl:ENSG00000167964(gene)|ensembl:ENST00000210187(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|refseq:NP_055168.2|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019002"(GMP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0035272"(exocrine system development)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0099575"(regulation of protein catabolic process at presynapse, modulating synaptic transmission)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2G6B|reactome:R-HSA-8873719|refseq:NP_001294982.1	-	-	-	figure legend:Fig6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/12/18	2019/08/20	rogid:wD58jj343lgoMJQZDBLLT3clak49606	rogid:kcmXxyYkndHxM/lz+XdGXI1qTzY9606	intact-crc:E24033CCAD883F79|rigid:6g3ih4w7gCER8J7J87f0k7dPCnc	false	venus fluorescent protein tag:?-?	mutation decreasing interaction strength:77-77|mutation decreasing interaction strength:177-177|renilla luciferase protein tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q9ULW5	uniprotkb:P18089	intact:EBI-958239|ensembl:ENSP00000210187|uniprotkb:Q6NXS7|intact:EBI-11079157|uniprotkb:Q3L6K5|uniprotkb:B2RAA6	intact:EBI-9077302|uniprotkb:Q4TUH9|uniprotkb:Q53RF2|uniprotkb:Q9BZK0|uniprotkb:A2RUS0|ensembl:ENSP00000480573	psi-mi:rab26_human(display_long)|uniprotkb:RAB26(gene name)|psi-mi:RAB26(display_short)	psi-mi:ada2b_human(display_long)|uniprotkb:ADRA2B(gene name)|psi-mi:ADRA2B(display_short)|uniprotkb:ADRA2L1(gene name synonym)|uniprotkb:ADRA2RL1(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C2(gene name synonym)|uniprotkb:Alpha-2B adrenoreceptor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2012)	imex:IM-22910|pubmed:23105096	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-9517407|imex:IM-22910-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000167964(gene)|ensembl:ENST00000210187(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|refseq:NP_055168.2|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019002"(GMP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0035272"(exocrine system development)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0099575"(regulation of protein catabolic process at presynapse, modulating synaptic transmission)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2G6B|reactome:R-HSA-8873719|refseq:NP_001294982.1	refseq:NP_000673.2|dip:DIP-61453N|ensembl:ENSG00000274286(gene)|ensembl:ENST00000620793(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0009986"(cell surface)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0030168"(platelet activation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0035624"(receptor transactivation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0051379"(epinephrine binding)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|interpro:IPR000207(Adrenergic receptor, alpha-2B)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2CVA|rcsb pdb:6K41|rcsb pdb:6K42|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-418594|reactome:R-HSA-418597	-	-	-	figure legend:Fig7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/18	2017/03/30	rogid:kcmXxyYkndHxM/lz+XdGXI1qTzY9606	rogid:wD58jj343lgoMJQZDBLLT3clak49606	intact-crc:98F4529E9A136000|rigid:6g3ih4w7gCER8J7J87f0k7dPCnc	false	green fluorescent protein tag:?-?|mutation decreasing interaction strength:77-77|mutation disrupting interaction strength:177-177|green fluorescent protein tag:?-?	polyprotein fragment:194-372|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9ULW5	uniprotkb:P18089	intact:EBI-958239|ensembl:ENSP00000210187|uniprotkb:Q6NXS7|intact:EBI-11079157|uniprotkb:Q3L6K5|uniprotkb:B2RAA6	intact:EBI-9077302|uniprotkb:Q4TUH9|uniprotkb:Q53RF2|uniprotkb:Q9BZK0|uniprotkb:A2RUS0|ensembl:ENSP00000480573	psi-mi:rab26_human(display_long)|uniprotkb:RAB26(gene name)|psi-mi:RAB26(display_short)	psi-mi:ada2b_human(display_long)|uniprotkb:ADRA2B(gene name)|psi-mi:ADRA2B(display_short)|uniprotkb:ADRA2L1(gene name synonym)|uniprotkb:ADRA2RL1(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C2(gene name synonym)|uniprotkb:Alpha-2B adrenoreceptor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2012)	imex:IM-22910|pubmed:23105096	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1262"(I2D)	intact:EBI-9632554|imex:IM-22910-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000167964(gene)|ensembl:ENST00000210187(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|refseq:NP_055168.2|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019002"(GMP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0035272"(exocrine system development)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0099575"(regulation of protein catabolic process at presynapse, modulating synaptic transmission)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2G6B|reactome:R-HSA-8873719|refseq:NP_001294982.1	refseq:NP_000673.2|dip:DIP-61453N|ensembl:ENSG00000274286(gene)|ensembl:ENST00000620793(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0009986"(cell surface)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0030168"(platelet activation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0035624"(receptor transactivation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0051379"(epinephrine binding)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|interpro:IPR000207(Adrenergic receptor, alpha-2B)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2CVA|rcsb pdb:6K41|rcsb pdb:6K42|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-418594|reactome:R-HSA-418597	-	-	-	figure legend:fig 7c|comment:The interaction of Rab26 with the GST-ICL3 was more potent in the present of GTP-gamma-S than in the presence of GDP|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/18	2017/03/30	rogid:kcmXxyYkndHxM/lz+XdGXI1qTzY9606	rogid:wD58jj343lgoMJQZDBLLT3clak49606	intact-crc:2A10252CAEC5F09B|rigid:6g3ih4w7gCER8J7J87f0k7dPCnc	false	-	polyprotein fragment:194-372	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)