#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15529	uniprotkb:P01024	intact:EBI-2623451|uniprotkb:A0T1T0|uniprotkb:A0T1T1|uniprotkb:Q9UCJ4|uniprotkb:Q5VWS7|uniprotkb:Q5VWT1|uniprotkb:Q7Z3R5|uniprotkb:Q9NNW2|uniprotkb:Q6N0A1|uniprotkb:Q5VWS6|uniprotkb:Q5VWS8|uniprotkb:A0T1T2|uniprotkb:Q9NNW3|uniprotkb:Q5HY94|uniprotkb:Q5VWS9|uniprotkb:Q53GV9|uniprotkb:Q15429|uniprotkb:Q9NNW4|uniprotkb:Q5VWT0|uniprotkb:Q5VWT2|ensembl:ENSP00000350893	intact:EBI-905851|uniprotkb:A7E236|ensembl:ENSP00000245907	psi-mi:mcp_human(display_long)|uniprotkb:MCP(gene name synonym)|uniprotkb:MIC10(gene name synonym)|uniprotkb:TLX(gene name synonym)|uniprotkb:Trophoblast leukocyte common antigen(gene name synonym)|uniprotkb:CD46(gene name)|psi-mi:CD46(display_short)	psi-mi:co3_human(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:CPAMD1(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Le et al. (2012)	imex:IM-20995|pubmed:23086448	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6858868|imex:IM-20995-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011507865.1|refseq:XP_011507866.1|refseq:NP_002380.3|refseq:NP_722548.1|refseq:NP_758860.1|refseq:NP_758861.1|refseq:NP_758862.1|refseq:NP_758863.1|refseq:NP_758869.1|refseq:NP_758871.1|refseq:XP_016856797.1|refseq:XP_016856798.1|refseq:XP_016856799.1|ensembl:ENSG00000117335(gene)|ensembl:ENST00000358170(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002079"(inner acrosomal membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035581"(sequestering of extracellular ligand from receptor)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR017341(Membrane cofactor protein, CD46)|interpro:IPR035976|rcsb pdb:1CKL|rcsb pdb:1HR4|rcsb pdb:2O39|rcsb pdb:3INB|rcsb pdb:3L89|rcsb pdb:3O8E|rcsb pdb:5FO8|reactome:R-HSA-977606|dip:DIP-41232N	refseq:NP_000055.2|dip:DIP-35180N|ensembl:ENSG00000125730(gene)|ensembl:ENST00000245907(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01024|rcsb pdb:1C3D|rcsb pdb:1GHQ|rcsb pdb:1W2S|rcsb pdb:2A73|rcsb pdb:2A74|rcsb pdb:2GOX|rcsb pdb:2I07|rcsb pdb:2ICE|rcsb pdb:2ICF|rcsb pdb:2NOJ|rcsb pdb:2QKI|rcsb pdb:2WII|rcsb pdb:2WIN|rcsb pdb:2WY7|rcsb pdb:2WY8|rcsb pdb:2XQW|rcsb pdb:2XWB|rcsb pdb:2XWJ|rcsb pdb:3D5R|rcsb pdb:3D5S|rcsb pdb:3G6J|rcsb pdb:3L3O|rcsb pdb:3L5N|rcsb pdb:3NMS|rcsb pdb:3OED|rcsb pdb:3OHX|rcsb pdb:3OXU|rcsb pdb:3RJ3|rcsb pdb:3T4A|rcsb pdb:4HW5|rcsb pdb:4HWJ|rcsb pdb:4I6O|rcsb pdb:4M76|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5FO7|rcsb pdb:5FO8|rcsb pdb:5FO9|rcsb pdb:5FOA|rcsb pdb:5FOB|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:6EHG|rcsb pdb:6RMT|rcsb pdb:6RMU|rcsb pdb:6RUR|rcsb pdb:6RUV|rcsb pdb:6S0B|rcsb pdb:6YO6|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-198933|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9660826|reactome:R-HSA-977606	-	-	-	figure legend:Fig. 1A.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/08	2014/10/16	rogid:nhB+pnkhLRsOA01ekJ50pkUu3og9606	rogid:6Axa89cCPpUXFsLnd7sCurZzLYI9606	intact-crc:B86A2FB0403D0A54|rigid:kH//1sY0k3C2Yj3xRKZ2JARVKqo	false	-	sufficient binding region:23..23-667..667	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78504	uniprotkb:P15529	intact:EBI-2847071|uniprotkb:B4DYR1|uniprotkb:E9PCF9|uniprotkb:O14902|uniprotkb:A0AV43|uniprotkb:O15122|uniprotkb:Q15816|ensembl:ENSP00000254958	intact:EBI-2623451|uniprotkb:A0T1T0|uniprotkb:A0T1T1|uniprotkb:Q9UCJ4|uniprotkb:Q5VWS7|uniprotkb:Q5VWT1|uniprotkb:Q7Z3R5|uniprotkb:Q9NNW2|uniprotkb:Q6N0A1|uniprotkb:Q5VWS6|uniprotkb:Q5VWS8|uniprotkb:A0T1T2|uniprotkb:Q9NNW3|uniprotkb:Q5HY94|uniprotkb:Q5VWS9|uniprotkb:Q53GV9|uniprotkb:Q15429|uniprotkb:Q9NNW4|uniprotkb:Q5VWT0|uniprotkb:Q5VWT2|ensembl:ENSP00000350893	psi-mi:jag1_human(display_long)|uniprotkb:JAG1(gene name)|psi-mi:JAG1(display_short)|uniprotkb:JAGL1(gene name synonym)	psi-mi:mcp_human(display_long)|uniprotkb:MCP(gene name synonym)|uniprotkb:MIC10(gene name synonym)|uniprotkb:TLX(gene name synonym)|uniprotkb:Trophoblast leukocyte common antigen(gene name synonym)|uniprotkb:CD46(gene name)|psi-mi:CD46(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Le et al. (2012)	imex:IM-20995|pubmed:23086448	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6858874|imex:IM-20995-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016883196.1|refseq:NP_000205.1|ensembl:ENST00000254958(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007399"(nervous system development)|ensembl:ENSG00000101384(gene)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061444"(endocardial cushion cell development)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0072006"(nephron development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072017"(distal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|go:"GO:0008083"(growth factor activity)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR026219|interpro:IPR033108|rcsb pdb:2KB9|rcsb pdb:2VJ2|rcsb pdb:4CBZ|rcsb pdb:4CC0|rcsb pdb:4CC1|rcsb pdb:4XI7|rcsb pdb:5BO1|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-8941856|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9013507|reactome:R-HSA-9013700|interpro:IPR001881(EGF-like calcium-binding)|dip:DIP-46371N	refseq:XP_011507865.1|refseq:XP_011507866.1|refseq:NP_002380.3|refseq:NP_722548.1|refseq:NP_758860.1|refseq:NP_758861.1|refseq:NP_758862.1|refseq:NP_758863.1|refseq:NP_758869.1|refseq:NP_758871.1|refseq:XP_016856797.1|refseq:XP_016856798.1|refseq:XP_016856799.1|ensembl:ENSG00000117335(gene)|ensembl:ENST00000358170(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002079"(inner acrosomal membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035581"(sequestering of extracellular ligand from receptor)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR017341(Membrane cofactor protein, CD46)|interpro:IPR035976|rcsb pdb:1CKL|rcsb pdb:1HR4|rcsb pdb:2O39|rcsb pdb:3INB|rcsb pdb:3L89|rcsb pdb:3O8E|rcsb pdb:5FO8|reactome:R-HSA-977606|dip:DIP-41232N	-	-	-	figure legend:Fig. 1A.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/08	2014/10/16	rogid:kaBPZjsO7mchlR6vYIknqvTluos9606	rogid:nhB+pnkhLRsOA01ekJ50pkUu3og9606	intact-crc:5169C50591243BE5|rigid:mPXWJw6IXwb7vxYqBcfQiCvmuuo	false	sufficient binding region:185..185-334..334	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78504	uniprotkb:P46531	intact:EBI-2847071|uniprotkb:B4DYR1|uniprotkb:E9PCF9|uniprotkb:O14902|uniprotkb:A0AV43|uniprotkb:O15122|uniprotkb:Q15816|ensembl:ENSP00000254958	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	psi-mi:jag1_human(display_long)|uniprotkb:JAG1(gene name)|psi-mi:JAG1(display_short)|uniprotkb:JAGL1(gene name synonym)	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Le et al. (2012)	imex:IM-20995|pubmed:23086448	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6858882|imex:IM-20995-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016883196.1|refseq:NP_000205.1|ensembl:ENST00000254958(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007399"(nervous system development)|ensembl:ENSG00000101384(gene)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061444"(endocardial cushion cell development)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0072006"(nephron development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072017"(distal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|go:"GO:0008083"(growth factor activity)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR026219|interpro:IPR033108|rcsb pdb:2KB9|rcsb pdb:2VJ2|rcsb pdb:4CBZ|rcsb pdb:4CC0|rcsb pdb:4CC1|rcsb pdb:4XI7|rcsb pdb:5BO1|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-8941856|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9013507|reactome:R-HSA-9013700|interpro:IPR001881(EGF-like calcium-binding)|dip:DIP-46371N	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/08	2014/10/16	rogid:kaBPZjsO7mchlR6vYIknqvTluos9606	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	intact-crc:C7873DE0C0169A5E|rigid:VijEn7Vsqk+SXYsPzk1EStHlzYQ	false	-	sufficient binding region:412..412-526..526	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78504	uniprotkb:P15529	intact:EBI-2847071|uniprotkb:B4DYR1|uniprotkb:E9PCF9|uniprotkb:O14902|uniprotkb:A0AV43|uniprotkb:O15122|uniprotkb:Q15816|ensembl:ENSP00000254958	intact:EBI-2623451|uniprotkb:A0T1T0|uniprotkb:A0T1T1|uniprotkb:Q9UCJ4|uniprotkb:Q5VWS7|uniprotkb:Q5VWT1|uniprotkb:Q7Z3R5|uniprotkb:Q9NNW2|uniprotkb:Q6N0A1|uniprotkb:Q5VWS6|uniprotkb:Q5VWS8|uniprotkb:A0T1T2|uniprotkb:Q9NNW3|uniprotkb:Q5HY94|uniprotkb:Q5VWS9|uniprotkb:Q53GV9|uniprotkb:Q15429|uniprotkb:Q9NNW4|uniprotkb:Q5VWT0|uniprotkb:Q5VWT2|ensembl:ENSP00000350893	psi-mi:jag1_human(display_long)|uniprotkb:JAG1(gene name)|psi-mi:JAG1(display_short)|uniprotkb:JAGL1(gene name synonym)	psi-mi:mcp_human(display_long)|uniprotkb:MCP(gene name synonym)|uniprotkb:MIC10(gene name synonym)|uniprotkb:TLX(gene name synonym)|uniprotkb:Trophoblast leukocyte common antigen(gene name synonym)|uniprotkb:CD46(gene name)|psi-mi:CD46(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Le et al. (2012)	imex:IM-20995|pubmed:23086448	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6858889|imex:IM-20995-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016883196.1|refseq:NP_000205.1|ensembl:ENST00000254958(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007399"(nervous system development)|ensembl:ENSG00000101384(gene)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061444"(endocardial cushion cell development)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0072006"(nephron development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072017"(distal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|go:"GO:0008083"(growth factor activity)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR026219|interpro:IPR033108|rcsb pdb:2KB9|rcsb pdb:2VJ2|rcsb pdb:4CBZ|rcsb pdb:4CC0|rcsb pdb:4CC1|rcsb pdb:4XI7|rcsb pdb:5BO1|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-8941856|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9013507|reactome:R-HSA-9013700|interpro:IPR001881(EGF-like calcium-binding)|dip:DIP-46371N	refseq:XP_011507865.1|refseq:XP_011507866.1|refseq:NP_002380.3|refseq:NP_722548.1|refseq:NP_758860.1|refseq:NP_758861.1|refseq:NP_758862.1|refseq:NP_758863.1|refseq:NP_758869.1|refseq:NP_758871.1|refseq:XP_016856797.1|refseq:XP_016856798.1|refseq:XP_016856799.1|ensembl:ENSG00000117335(gene)|ensembl:ENST00000358170(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002079"(inner acrosomal membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035581"(sequestering of extracellular ligand from receptor)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR017341(Membrane cofactor protein, CD46)|interpro:IPR035976|rcsb pdb:1CKL|rcsb pdb:1HR4|rcsb pdb:2O39|rcsb pdb:3INB|rcsb pdb:3L89|rcsb pdb:3O8E|rcsb pdb:5FO8|reactome:R-HSA-977606|dip:DIP-41232N	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/08	2014/10/16	rogid:kaBPZjsO7mchlR6vYIknqvTluos9606	rogid:nhB+pnkhLRsOA01ekJ50pkUu3og9606	intact-crc:C8A7A2D515171ECF|rigid:mPXWJw6IXwb7vxYqBcfQiCvmuuo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15529	uniprotkb:P78504	intact:EBI-2623451|uniprotkb:A0T1T0|uniprotkb:A0T1T1|uniprotkb:Q9UCJ4|uniprotkb:Q5VWS7|uniprotkb:Q5VWT1|uniprotkb:Q7Z3R5|uniprotkb:Q9NNW2|uniprotkb:Q6N0A1|uniprotkb:Q5VWS6|uniprotkb:Q5VWS8|uniprotkb:A0T1T2|uniprotkb:Q9NNW3|uniprotkb:Q5HY94|uniprotkb:Q5VWS9|uniprotkb:Q53GV9|uniprotkb:Q15429|uniprotkb:Q9NNW4|uniprotkb:Q5VWT0|uniprotkb:Q5VWT2|ensembl:ENSP00000350893	intact:EBI-2847071|uniprotkb:B4DYR1|uniprotkb:E9PCF9|uniprotkb:O14902|uniprotkb:A0AV43|uniprotkb:O15122|uniprotkb:Q15816|ensembl:ENSP00000254958	psi-mi:mcp_human(display_long)|uniprotkb:MCP(gene name synonym)|uniprotkb:MIC10(gene name synonym)|uniprotkb:TLX(gene name synonym)|uniprotkb:Trophoblast leukocyte common antigen(gene name synonym)|uniprotkb:CD46(gene name)|psi-mi:CD46(display_short)	psi-mi:jag1_human(display_long)|uniprotkb:JAG1(gene name)|psi-mi:JAG1(display_short)|uniprotkb:JAGL1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Le et al. (2012)	imex:IM-20995|pubmed:23086448	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6858901|imex:IM-20995-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011507865.1|refseq:XP_011507866.1|refseq:NP_002380.3|refseq:NP_722548.1|refseq:NP_758860.1|refseq:NP_758861.1|refseq:NP_758862.1|refseq:NP_758863.1|refseq:NP_758869.1|refseq:NP_758871.1|refseq:XP_016856797.1|refseq:XP_016856798.1|refseq:XP_016856799.1|ensembl:ENSG00000117335(gene)|ensembl:ENST00000358170(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002079"(inner acrosomal membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035581"(sequestering of extracellular ligand from receptor)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR017341(Membrane cofactor protein, CD46)|interpro:IPR035976|rcsb pdb:1CKL|rcsb pdb:1HR4|rcsb pdb:2O39|rcsb pdb:3INB|rcsb pdb:3L89|rcsb pdb:3O8E|rcsb pdb:5FO8|reactome:R-HSA-977606|dip:DIP-41232N	refseq:XP_016883196.1|refseq:NP_000205.1|ensembl:ENST00000254958(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007399"(nervous system development)|ensembl:ENSG00000101384(gene)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061444"(endocardial cushion cell development)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0072006"(nephron development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072017"(distal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|go:"GO:0008083"(growth factor activity)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR026219|interpro:IPR033108|rcsb pdb:2KB9|rcsb pdb:2VJ2|rcsb pdb:4CBZ|rcsb pdb:4CC0|rcsb pdb:4CC1|rcsb pdb:4XI7|rcsb pdb:5BO1|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-8941856|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9013507|reactome:R-HSA-9013700|interpro:IPR001881(EGF-like calcium-binding)|dip:DIP-46371N	-	-	-	figure legend:Fig. 2A, 2B, 2C, 2D.|comment:"Kd for CD46(1-4) = 8 uM, CD46(1-3) = 8.8 uM."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:8.4x10^-6(molar)	2013/06/08	2014/10/16	rogid:nhB+pnkhLRsOA01ekJ50pkUu3og9606	rogid:kaBPZjsO7mchlR6vYIknqvTluos9606	intact-crc:3CCD0C4FBC99DE44|rigid:mPXWJw6IXwb7vxYqBcfQiCvmuuo	false	sufficient binding region:35..35-159..159	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78504	uniprotkb:P15529	intact:EBI-2847071|uniprotkb:B4DYR1|uniprotkb:E9PCF9|uniprotkb:O14902|uniprotkb:A0AV43|uniprotkb:O15122|uniprotkb:Q15816|ensembl:ENSP00000254958	intact:EBI-2623451|uniprotkb:A0T1T0|uniprotkb:A0T1T1|uniprotkb:Q9UCJ4|uniprotkb:Q5VWS7|uniprotkb:Q5VWT1|uniprotkb:Q7Z3R5|uniprotkb:Q9NNW2|uniprotkb:Q6N0A1|uniprotkb:Q5VWS6|uniprotkb:Q5VWS8|uniprotkb:A0T1T2|uniprotkb:Q9NNW3|uniprotkb:Q5HY94|uniprotkb:Q5VWS9|uniprotkb:Q53GV9|uniprotkb:Q15429|uniprotkb:Q9NNW4|uniprotkb:Q5VWT0|uniprotkb:Q5VWT2|ensembl:ENSP00000350893	psi-mi:jag1_human(display_long)|uniprotkb:JAG1(gene name)|psi-mi:JAG1(display_short)|uniprotkb:JAGL1(gene name synonym)	psi-mi:mcp_human(display_long)|uniprotkb:MCP(gene name synonym)|uniprotkb:MIC10(gene name synonym)|uniprotkb:TLX(gene name synonym)|uniprotkb:Trophoblast leukocyte common antigen(gene name synonym)|uniprotkb:CD46(gene name)|psi-mi:CD46(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Le et al. (2012)	imex:IM-20995|pubmed:23086448	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6858916|imex:IM-20995-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016883196.1|refseq:NP_000205.1|ensembl:ENST00000254958(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007399"(nervous system development)|ensembl:ENSG00000101384(gene)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061444"(endocardial cushion cell development)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0072006"(nephron development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072017"(distal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|go:"GO:0008083"(growth factor activity)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR026219|interpro:IPR033108|rcsb pdb:2KB9|rcsb pdb:2VJ2|rcsb pdb:4CBZ|rcsb pdb:4CC0|rcsb pdb:4CC1|rcsb pdb:4XI7|rcsb pdb:5BO1|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-8941856|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9013507|reactome:R-HSA-9013700|interpro:IPR001881(EGF-like calcium-binding)|dip:DIP-46371N	refseq:XP_011507865.1|refseq:XP_011507866.1|refseq:NP_002380.3|refseq:NP_722548.1|refseq:NP_758860.1|refseq:NP_758861.1|refseq:NP_758862.1|refseq:NP_758863.1|refseq:NP_758869.1|refseq:NP_758871.1|refseq:XP_016856797.1|refseq:XP_016856798.1|refseq:XP_016856799.1|ensembl:ENSG00000117335(gene)|ensembl:ENST00000358170(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002079"(inner acrosomal membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035581"(sequestering of extracellular ligand from receptor)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR017341(Membrane cofactor protein, CD46)|interpro:IPR035976|rcsb pdb:1CKL|rcsb pdb:1HR4|rcsb pdb:2O39|rcsb pdb:3INB|rcsb pdb:3L89|rcsb pdb:3O8E|rcsb pdb:5FO8|reactome:R-HSA-977606|dip:DIP-41232N	-	-	-	figure legend:Fig. 2E, 2F.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/08	2014/10/16	rogid:kaBPZjsO7mchlR6vYIknqvTluos9606	rogid:nhB+pnkhLRsOA01ekJ50pkUu3og9606	intact-crc:809DE9915A403AA8|rigid:mPXWJw6IXwb7vxYqBcfQiCvmuuo	false	-	sufficient binding region:35..35-159..159	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15529	uniprotkb:P78504	intact:EBI-2623451|uniprotkb:A0T1T0|uniprotkb:A0T1T1|uniprotkb:Q9UCJ4|uniprotkb:Q5VWS7|uniprotkb:Q5VWT1|uniprotkb:Q7Z3R5|uniprotkb:Q9NNW2|uniprotkb:Q6N0A1|uniprotkb:Q5VWS6|uniprotkb:Q5VWS8|uniprotkb:A0T1T2|uniprotkb:Q9NNW3|uniprotkb:Q5HY94|uniprotkb:Q5VWS9|uniprotkb:Q53GV9|uniprotkb:Q15429|uniprotkb:Q9NNW4|uniprotkb:Q5VWT0|uniprotkb:Q5VWT2|ensembl:ENSP00000350893	intact:EBI-2847071|uniprotkb:B4DYR1|uniprotkb:E9PCF9|uniprotkb:O14902|uniprotkb:A0AV43|uniprotkb:O15122|uniprotkb:Q15816|ensembl:ENSP00000254958	psi-mi:mcp_human(display_long)|uniprotkb:MCP(gene name synonym)|uniprotkb:MIC10(gene name synonym)|uniprotkb:TLX(gene name synonym)|uniprotkb:Trophoblast leukocyte common antigen(gene name synonym)|uniprotkb:CD46(gene name)|psi-mi:CD46(display_short)	psi-mi:jag1_human(display_long)|uniprotkb:JAG1(gene name)|psi-mi:JAG1(display_short)|uniprotkb:JAGL1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Le et al. (2012)	imex:IM-20995|pubmed:23086448	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6858931|imex:IM-20995-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011507865.1|refseq:XP_011507866.1|refseq:NP_002380.3|refseq:NP_722548.1|refseq:NP_758860.1|refseq:NP_758861.1|refseq:NP_758862.1|refseq:NP_758863.1|refseq:NP_758869.1|refseq:NP_758871.1|refseq:XP_016856797.1|refseq:XP_016856798.1|refseq:XP_016856799.1|ensembl:ENSG00000117335(gene)|ensembl:ENST00000358170(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002079"(inner acrosomal membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035581"(sequestering of extracellular ligand from receptor)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR017341(Membrane cofactor protein, CD46)|interpro:IPR035976|rcsb pdb:1CKL|rcsb pdb:1HR4|rcsb pdb:2O39|rcsb pdb:3INB|rcsb pdb:3L89|rcsb pdb:3O8E|rcsb pdb:5FO8|reactome:R-HSA-977606|dip:DIP-41232N	refseq:XP_016883196.1|refseq:NP_000205.1|ensembl:ENST00000254958(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007399"(nervous system development)|ensembl:ENSG00000101384(gene)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061444"(endocardial cushion cell development)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0072006"(nephron development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072017"(distal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|go:"GO:0008083"(growth factor activity)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR026219|interpro:IPR033108|rcsb pdb:2KB9|rcsb pdb:2VJ2|rcsb pdb:4CBZ|rcsb pdb:4CC0|rcsb pdb:4CC1|rcsb pdb:4XI7|rcsb pdb:5BO1|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-8941856|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9013507|reactome:R-HSA-9013700|interpro:IPR001881(EGF-like calcium-binding)|dip:DIP-46371N	-	-	-	figure legend:Fig. 4C.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell)|taxid:9606(Homo sapiens)	-	2013/06/08	2014/10/16	rogid:nhB+pnkhLRsOA01ekJ50pkUu3og9606	rogid:kaBPZjsO7mchlR6vYIknqvTluos9606	intact-crc:DFA3D1570CEF9A50|rigid:mPXWJw6IXwb7vxYqBcfQiCvmuuo	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P78504	uniprotkb:P46531	intact:EBI-2847071|uniprotkb:B4DYR1|uniprotkb:E9PCF9|uniprotkb:O14902|uniprotkb:A0AV43|uniprotkb:O15122|uniprotkb:Q15816|ensembl:ENSP00000254958	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	psi-mi:jag1_human(display_long)|uniprotkb:JAG1(gene name)|psi-mi:JAG1(display_short)|uniprotkb:JAGL1(gene name synonym)	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Le et al. (2012)	imex:IM-20995|pubmed:23086448	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6858935|imex:IM-20995-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016883196.1|refseq:NP_000205.1|ensembl:ENST00000254958(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001709"(cell fate determination)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007399"(nervous system development)|ensembl:ENSG00000101384(gene)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061444"(endocardial cushion cell development)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0072006"(nephron development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072017"(distal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|go:"GO:0008083"(growth factor activity)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR026219|interpro:IPR033108|rcsb pdb:2KB9|rcsb pdb:2VJ2|rcsb pdb:4CBZ|rcsb pdb:4CC0|rcsb pdb:4CC1|rcsb pdb:4XI7|rcsb pdb:5BO1|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-8941856|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9013507|reactome:R-HSA-9013700|interpro:IPR001881(EGF-like calcium-binding)|dip:DIP-46371N	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	-	-	-	figure legend:Fig. 4C|agonist:anti-CD3 and anti-CD46|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell)|taxid:9606(Homo sapiens)	-	2013/06/08	2014/10/16	rogid:kaBPZjsO7mchlR6vYIknqvTluos9606	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	intact-crc:B7E353FE8F1DC248|rigid:VijEn7Vsqk+SXYsPzk1EStHlzYQ	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)